-- dump date   	20140618_183355
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
329726000001	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
329726000002	nudix motif; other site
329726000003	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
329726000004	Protein phosphatase 2C; Region: PP2C_2; pfam13672
329726000005	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
329726000006	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
329726000007	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
329726000008	FOG: CBS domain [General function prediction only]; Region: COG0517
329726000009	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636
329726000010	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
329726000011	homotrimer interaction site [polypeptide binding]; other site
329726000012	active site
329726000013	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
329726000014	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
329726000015	tandem repeat interface [polypeptide binding]; other site
329726000016	oligomer interface [polypeptide binding]; other site
329726000017	active site residues [active]
329726000018	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
329726000019	EamA-like transporter family; Region: EamA; pfam00892
329726000020	EamA-like transporter family; Region: EamA; pfam00892
329726000021	uracil-xanthine permease; Region: ncs2; TIGR00801
329726000022	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
329726000023	Response regulator receiver domain; Region: Response_reg; pfam00072
329726000024	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726000025	active site
329726000026	phosphorylation site [posttranslational modification]
329726000027	intermolecular recognition site; other site
329726000028	dimerization interface [polypeptide binding]; other site
329726000029	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726000030	PAS fold; Region: PAS_3; pfam08447
329726000031	putative active site [active]
329726000032	heme pocket [chemical binding]; other site
329726000033	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726000034	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726000035	metal binding site [ion binding]; metal-binding site
329726000036	active site
329726000037	I-site; other site
329726000038	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726000039	Cache domain; Region: Cache_1; pfam02743
329726000040	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
329726000041	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726000042	dimerization interface [polypeptide binding]; other site
329726000043	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726000044	dimer interface [polypeptide binding]; other site
329726000045	phosphorylation site [posttranslational modification]
329726000046	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726000047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726000048	ATP binding site [chemical binding]; other site
329726000049	Mg2+ binding site [ion binding]; other site
329726000050	G-X-G motif; other site
329726000051	Response regulator receiver domain; Region: Response_reg; pfam00072
329726000052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726000053	active site
329726000054	phosphorylation site [posttranslational modification]
329726000055	intermolecular recognition site; other site
329726000056	dimerization interface [polypeptide binding]; other site
329726000057	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726000058	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726000059	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726000060	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
329726000061	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
329726000062	putative active site [active]
329726000063	PhoH-like protein; Region: PhoH; pfam02562
329726000064	Transthyretin-like family; Region: DUF290; pfam01060
329726000065	Caspase domain; Region: Peptidase_C14; pfam00656
329726000066	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726000067	structural tetrad; other site
329726000068	PQQ-like domain; Region: PQQ_2; pfam13360
329726000069	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
329726000070	Switch II region; other site
329726000071	G4 box; other site
329726000072	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726000073	TPR motif; other site
329726000074	Tetratricopeptide repeat; Region: TPR_16; pfam13432
329726000075	binding surface
329726000076	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
329726000077	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726000078	S-adenosylmethionine binding site [chemical binding]; other site
329726000079	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
329726000080	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
329726000081	substrate binding site [chemical binding]; other site
329726000082	ATP binding site [chemical binding]; other site
329726000083	MAPEG family; Region: MAPEG; cl09190
329726000084	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726000085	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726000086	DNA binding residues [nucleotide binding]
329726000087	dimerization interface [polypeptide binding]; other site
329726000088	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726000089	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726000090	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
329726000091	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
329726000092	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
329726000093	hydrophobic ligand binding site; other site
329726000094	Pheophorbide a oxygenase; Region: PaO; pfam08417
329726000095	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
329726000096	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase
329726000097	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726000098	YceG-like family; Region: YceG; pfam02618
329726000099	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
329726000100	dimerization interface [polypeptide binding]; other site
329726000101	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
329726000102	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
329726000103	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
329726000104	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726000105	Coenzyme A binding pocket [chemical binding]; other site
329726000106	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
329726000107	S-layer homology domain; Region: SLH; pfam00395
329726000108	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
329726000109	HEAT repeats; Region: HEAT_2; pfam13646
329726000110	HEAT repeats; Region: HEAT_2; pfam13646
329726000111	HEAT repeats; Region: HEAT_2; pfam13646
329726000112	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
329726000113	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726000114	NAD(P) binding site [chemical binding]; other site
329726000115	active site
329726000116	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
329726000117	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
329726000118	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
329726000119	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726000120	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726000121	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726000122	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726000123	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
329726000124	NADH(P)-binding; Region: NAD_binding_10; pfam13460
329726000125	NAD(P) binding site [chemical binding]; other site
329726000126	putative active site [active]
329726000127	Bacterial SH3 domain; Region: SH3_3; cl17532
329726000128	Uncharacterized protein conserved in archaea (DUF2153); Region: DUF2153; cl01966
329726000129	Bacterial SH3 domain; Region: SH3_3; cl17532
329726000130	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
329726000131	Protein of unknown function (DUF790); Region: DUF790; pfam05626
329726000132	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
329726000133	Leucine-rich repeats; other site
329726000134	Substrate binding site [chemical binding]; other site
329726000135	Leucine rich repeat; Region: LRR_8; pfam13855
329726000136	Leucine rich repeat; Region: LRR_8; pfam13855
329726000137	Leucine rich repeat; Region: LRR_8; pfam13855
329726000138	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
329726000139	putative hydrophobic ligand binding site [chemical binding]; other site
329726000140	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
329726000141	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
329726000142	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726000143	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
329726000144	Transposase; Region: HTH_Tnp_1; cl17663
329726000145	putative transposase OrfB; Reviewed; Region: PHA02517
329726000146	HTH-like domain; Region: HTH_21; pfam13276
329726000147	Integrase core domain; Region: rve; pfam00665
329726000148	Integrase core domain; Region: rve_3; pfam13683
329726000149	Transposase, Mutator family; Region: Transposase_mut; pfam00872
329726000150	MULE transposase domain; Region: MULE; pfam10551
329726000151	Cupin domain; Region: Cupin_2; cl17218
329726000152	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
329726000153	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
329726000154	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
329726000155	G1 box; other site
329726000156	putative GEF interaction site [polypeptide binding]; other site
329726000157	GTP/Mg2+ binding site [chemical binding]; other site
329726000158	Switch I region; other site
329726000159	G2 box; other site
329726000160	G3 box; other site
329726000161	Switch II region; other site
329726000162	G4 box; other site
329726000163	G5 box; other site
329726000164	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
329726000165	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
329726000166	PAS domain; Region: PAS_9; pfam13426
329726000167	PAS fold; Region: PAS_4; pfam08448
329726000168	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726000169	putative active site [active]
329726000170	heme pocket [chemical binding]; other site
329726000171	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726000172	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726000173	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726000174	PAS domain; Region: PAS_9; pfam13426
329726000175	putative active site [active]
329726000176	heme pocket [chemical binding]; other site
329726000177	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726000178	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726000179	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726000180	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726000181	dimer interface [polypeptide binding]; other site
329726000182	phosphorylation site [posttranslational modification]
329726000183	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726000184	ATP binding site [chemical binding]; other site
329726000185	Mg2+ binding site [ion binding]; other site
329726000186	G-X-G motif; other site
329726000187	Response regulator receiver domain; Region: Response_reg; pfam00072
329726000188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726000189	active site
329726000190	phosphorylation site [posttranslational modification]
329726000191	intermolecular recognition site; other site
329726000192	dimerization interface [polypeptide binding]; other site
329726000193	Response regulator receiver domain; Region: Response_reg; pfam00072
329726000194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726000195	active site
329726000196	phosphorylation site [posttranslational modification]
329726000197	intermolecular recognition site; other site
329726000198	dimerization interface [polypeptide binding]; other site
329726000199	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726000200	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726000201	metal binding site [ion binding]; metal-binding site
329726000202	active site
329726000203	I-site; other site
329726000204	Uncharacterized conserved protein [Function unknown]; Region: COG0432
329726000205	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
329726000206	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
329726000207	Mechanosensitive ion channel; Region: MS_channel; pfam00924
329726000208	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
329726000209	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
329726000210	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
329726000211	Family of unknown function (DUF490); Region: DUF490; pfam04357
329726000212	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726000213	haemagglutination activity domain; Region: Haemagg_act; pfam05860
329726000214	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
329726000215	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
329726000216	oligomer interface [polypeptide binding]; other site
329726000217	metal binding site [ion binding]; metal-binding site
329726000218	metal binding site [ion binding]; metal-binding site
329726000219	Cl binding site [ion binding]; other site
329726000220	aspartate ring; other site
329726000221	basic sphincter; other site
329726000222	putative hydrophobic gate; other site
329726000223	periplasmic entrance; other site
329726000224	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726000225	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726000226	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726000227	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726000228	TPR repeat; Region: TPR_11; pfam13414
329726000229	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726000230	binding surface
329726000231	TPR motif; other site
329726000232	Tetratricopeptide repeat; Region: TPR_16; pfam13432
329726000233	Rhomboid family; Region: Rhomboid; cl11446
329726000234	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
329726000235	active site
329726000236	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
329726000237	substrate binding site [chemical binding]; other site
329726000238	metal binding site [ion binding]; metal-binding site
329726000239	protein-export membrane protein SecD; Region: secD; TIGR01129
329726000240	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
329726000241	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
329726000242	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
329726000243	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
329726000244	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
329726000245	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
329726000246	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
329726000247	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
329726000248	active site
329726000249	zinc binding site [ion binding]; other site
329726000250	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726000251	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726000252	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726000253	Transposase, Mutator family; Region: Transposase_mut; pfam00872
329726000254	MULE transposase domain; Region: MULE; pfam10551
329726000255	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
329726000256	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
329726000257	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726000258	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726000259	binding surface
329726000260	TPR motif; other site
329726000261	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726000262	TPR motif; other site
329726000263	binding surface
329726000264	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726000265	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726000266	binding surface
329726000267	TPR motif; other site
329726000268	CHAT domain; Region: CHAT; pfam12770
329726000269	Domain of unknown function (DUF4329); Region: DUF4329; pfam14220
329726000270	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
329726000271	Right handed beta helix region; Region: Beta_helix; pfam13229
329726000272	Right handed beta helix region; Region: Beta_helix; pfam13229
329726000273	TIGR03032 family protein; Region: TIGR03032
329726000274	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
329726000275	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
329726000276	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
329726000277	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
329726000278	Flavoprotein; Region: Flavoprotein; pfam02441
329726000279	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
329726000280	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
329726000281	trimer interface [polypeptide binding]; other site
329726000282	dimer interface [polypeptide binding]; other site
329726000283	putative active site [active]
329726000284	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
329726000285	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
329726000286	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
329726000287	GIY-YIG motif/motif A; other site
329726000288	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
329726000289	Uncharacterized conserved protein [Function unknown]; Region: COG2128
329726000290	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
329726000291	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726000292	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726000293	DNA binding residues [nucleotide binding]
329726000294	Putative molybdenum carrier; Region: MoCo_carrier; pfam12694
329726000295	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
329726000296	putative hydrophobic ligand binding site [chemical binding]; other site
329726000297	protein interface [polypeptide binding]; other site
329726000298	gate; other site
329726000299	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
329726000300	Homeodomain-like domain; Region: HTH_23; pfam13384
329726000301	Winged helix-turn helix; Region: HTH_29; pfam13551
329726000302	Winged helix-turn helix; Region: HTH_33; pfam13592
329726000303	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726000304	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726000305	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
329726000306	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
329726000307	ATP binding site [chemical binding]; other site
329726000308	Mg++ binding site [ion binding]; other site
329726000309	motif III; other site
329726000310	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726000311	nucleotide binding region [chemical binding]; other site
329726000312	ATP-binding site [chemical binding]; other site
329726000313	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
329726000314	putative RNA binding site [nucleotide binding]; other site
329726000315	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
329726000316	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
329726000317	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
329726000318	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
329726000319	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
329726000320	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
329726000321	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
329726000322	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726000323	Walker A/P-loop; other site
329726000324	ATP binding site [chemical binding]; other site
329726000325	Q-loop/lid; other site
329726000326	ABC transporter signature motif; other site
329726000327	Walker B; other site
329726000328	D-loop; other site
329726000329	H-loop/switch region; other site
329726000330	glucokinase; Provisional; Region: glk; PRK00292
329726000331	glucokinase, proteobacterial type; Region: glk; TIGR00749
329726000332	mercuric reductase; Validated; Region: PRK06370
329726000333	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
329726000334	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
329726000335	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
329726000336	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
329726000337	Ca binding site [ion binding]; other site
329726000338	active site
329726000339	catalytic site [active]
329726000340	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
329726000341	active site
329726000342	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
329726000343	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
329726000344	active site
329726000345	ATP binding site [chemical binding]; other site
329726000346	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
329726000347	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
329726000348	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
329726000349	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
329726000350	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
329726000351	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
329726000352	aspartate aminotransferase; Provisional; Region: PRK05957
329726000353	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
329726000354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726000355	homodimer interface [polypeptide binding]; other site
329726000356	catalytic residue [active]
329726000357	Ion channel; Region: Ion_trans_2; pfam07885
329726000358	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
329726000359	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
329726000360	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
329726000361	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
329726000362	iron-sulfur cluster [ion binding]; other site
329726000363	[2Fe-2S] cluster binding site [ion binding]; other site
329726000364	Homeodomain-like domain; Region: HTH_23; pfam13384
329726000365	Winged helix-turn helix; Region: HTH_29; pfam13551
329726000366	Winged helix-turn helix; Region: HTH_33; pfam13592
329726000367	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726000368	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726000369	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
329726000370	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
329726000371	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
329726000372	AAA ATPase domain; Region: AAA_16; pfam13191
329726000373	NACHT domain; Region: NACHT; pfam05729
329726000374	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726000375	structural tetrad; other site
329726000376	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726000377	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726000378	structural tetrad; other site
329726000379	PBP superfamily domain; Region: PBP_like_2; cl17296
329726000380	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
329726000381	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
329726000382	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
329726000383	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
329726000384	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
329726000385	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726000386	sequence-specific DNA binding site [nucleotide binding]; other site
329726000387	salt bridge; other site
329726000388	NACHT domain; Region: NACHT; pfam05729
329726000389	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
329726000390	WD40 repeats; Region: WD40; smart00320
329726000391	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726000392	structural tetrad; other site
329726000393	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726000394	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726000395	structural tetrad; other site
329726000396	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
329726000397	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
329726000398	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
329726000399	Walker A/P-loop; other site
329726000400	ATP binding site [chemical binding]; other site
329726000401	Q-loop/lid; other site
329726000402	ABC transporter signature motif; other site
329726000403	Walker B; other site
329726000404	D-loop; other site
329726000405	H-loop/switch region; other site
329726000406	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
329726000407	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
329726000408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726000409	dimer interface [polypeptide binding]; other site
329726000410	conserved gate region; other site
329726000411	putative PBP binding loops; other site
329726000412	ABC-ATPase subunit interface; other site
329726000413	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
329726000414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726000415	dimer interface [polypeptide binding]; other site
329726000416	conserved gate region; other site
329726000417	putative PBP binding loops; other site
329726000418	ABC-ATPase subunit interface; other site
329726000419	PBP superfamily domain; Region: PBP_like_2; cl17296
329726000420	Uncharacterized conserved protein [Function unknown]; Region: COG5607
329726000421	Transposase IS200 like; Region: Y1_Tnp; cl00848
329726000422	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
329726000423	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
329726000424	HSP70 interaction site [polypeptide binding]; other site
329726000425	Tetratricopeptide repeat; Region: TPR_16; pfam13432
329726000426	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
329726000427	anti sigma factor interaction site; other site
329726000428	regulatory phosphorylation site [posttranslational modification]; other site
329726000429	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726000430	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726000431	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726000432	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
329726000433	dihydropteroate synthase; Region: DHPS; TIGR01496
329726000434	substrate binding pocket [chemical binding]; other site
329726000435	dimer interface [polypeptide binding]; other site
329726000436	inhibitor binding site; inhibition site
329726000437	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726000438	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726000439	metal binding site [ion binding]; metal-binding site
329726000440	active site
329726000441	I-site; other site
329726000442	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726000443	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726000444	dimer interface [polypeptide binding]; other site
329726000445	phosphorylation site [posttranslational modification]
329726000446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726000447	ATP binding site [chemical binding]; other site
329726000448	Mg2+ binding site [ion binding]; other site
329726000449	G-X-G motif; other site
329726000450	Response regulator receiver domain; Region: Response_reg; pfam00072
329726000451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726000452	active site
329726000453	phosphorylation site [posttranslational modification]
329726000454	intermolecular recognition site; other site
329726000455	dimerization interface [polypeptide binding]; other site
329726000456	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
329726000457	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726000458	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726000459	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726000460	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726000461	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726000462	short chain dehydrogenase; Provisional; Region: PRK06180
329726000463	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
329726000464	NADP binding site [chemical binding]; other site
329726000465	active site
329726000466	steroid binding site; other site
329726000467	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726000468	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726000469	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
329726000470	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
329726000471	potential catalytic triad [active]
329726000472	conserved cys residue [active]
329726000473	CHASE3 domain; Region: CHASE3; cl05000
329726000474	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
329726000475	classical (c) SDRs; Region: SDR_c; cd05233
329726000476	NAD(P) binding site [chemical binding]; other site
329726000477	active site
329726000478	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726000479	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726000480	ligand binding site [chemical binding]; other site
329726000481	flexible hinge region; other site
329726000482	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
329726000483	heme-binding site [chemical binding]; other site
329726000484	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
329726000485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726000486	Predicted membrane protein [Function unknown]; Region: COG2259
329726000487	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726000488	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726000489	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726000490	dimer interface [polypeptide binding]; other site
329726000491	phosphorylation site [posttranslational modification]
329726000492	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726000493	ATP binding site [chemical binding]; other site
329726000494	Mg2+ binding site [ion binding]; other site
329726000495	G-X-G motif; other site
329726000496	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726000497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726000498	active site
329726000499	phosphorylation site [posttranslational modification]
329726000500	intermolecular recognition site; other site
329726000501	dimerization interface [polypeptide binding]; other site
329726000502	Response regulator receiver domain; Region: Response_reg; pfam00072
329726000503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726000504	active site
329726000505	phosphorylation site [posttranslational modification]
329726000506	intermolecular recognition site; other site
329726000507	dimerization interface [polypeptide binding]; other site
329726000508	TPR repeat; Region: TPR_11; pfam13414
329726000509	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726000510	TPR motif; other site
329726000511	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726000512	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726000513	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726000514	phosphopeptide binding site; other site
329726000515	PAS domain; Region: PAS_9; pfam13426
329726000516	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726000517	putative active site [active]
329726000518	heme pocket [chemical binding]; other site
329726000519	PAS fold; Region: PAS_4; pfam08448
329726000520	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726000521	putative active site [active]
329726000522	heme pocket [chemical binding]; other site
329726000523	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
329726000524	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726000525	dimer interface [polypeptide binding]; other site
329726000526	phosphorylation site [posttranslational modification]
329726000527	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726000528	ATP binding site [chemical binding]; other site
329726000529	Mg2+ binding site [ion binding]; other site
329726000530	G-X-G motif; other site
329726000531	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726000532	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726000533	phosphopeptide binding site; other site
329726000534	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
329726000535	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
329726000536	integrase; Provisional; Region: PRK09692
329726000537	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
329726000538	active site
329726000539	Int/Topo IB signature motif; other site
329726000540	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
329726000541	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
329726000542	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
329726000543	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
329726000544	XdhC Rossmann domain; Region: XdhC_C; pfam13478
329726000545	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726000546	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726000547	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726000548	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726000549	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726000550	EamA-like transporter family; Region: EamA; pfam00892
329726000551	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
329726000552	EamA-like transporter family; Region: EamA; pfam00892
329726000553	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
329726000554	Inward rectifier potassium channel; Region: IRK; pfam01007
329726000555	TPR repeat; Region: TPR_11; pfam13414
329726000556	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726000557	binding surface
329726000558	TPR motif; other site
329726000559	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
329726000560	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726000561	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726000562	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
329726000563	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
329726000564	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726000565	Walker A motif; other site
329726000566	ATP binding site [chemical binding]; other site
329726000567	Walker B motif; other site
329726000568	arginine finger; other site
329726000569	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
329726000570	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726000571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726000572	active site
329726000573	phosphorylation site [posttranslational modification]
329726000574	intermolecular recognition site; other site
329726000575	dimerization interface [polypeptide binding]; other site
329726000576	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726000577	DNA binding residues [nucleotide binding]
329726000578	dimerization interface [polypeptide binding]; other site
329726000579	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726000580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726000581	ATP binding site [chemical binding]; other site
329726000582	Mg2+ binding site [ion binding]; other site
329726000583	G-X-G motif; other site
329726000584	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
329726000585	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
329726000586	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
329726000587	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
329726000588	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
329726000589	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
329726000590	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
329726000591	active site
329726000592	ATP binding site [chemical binding]; other site
329726000593	substrate binding site [chemical binding]; other site
329726000594	PBP superfamily domain; Region: PBP_like_2; cl17296
329726000595	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
329726000596	Uncharacterized family of heme peroxidases, mostly bacterial; Region: peroxinectin_like_bacterial; cd09822
329726000597	putative heme binding site [chemical binding]; other site
329726000598	putative substrate binding site [chemical binding]; other site
329726000599	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726000600	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
329726000601	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
329726000602	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
329726000603	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
329726000604	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726000605	ATP binding site [chemical binding]; other site
329726000606	putative Mg++ binding site [ion binding]; other site
329726000607	nucleotide binding region [chemical binding]; other site
329726000608	helicase superfamily c-terminal domain; Region: HELICc; smart00490
329726000609	ATP-binding site [chemical binding]; other site
329726000610	Response regulator receiver domain; Region: Response_reg; pfam00072
329726000611	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726000612	active site
329726000613	phosphorylation site [posttranslational modification]
329726000614	intermolecular recognition site; other site
329726000615	dimerization interface [polypeptide binding]; other site
329726000616	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726000617	dimer interface [polypeptide binding]; other site
329726000618	phosphorylation site [posttranslational modification]
329726000619	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726000620	ATP binding site [chemical binding]; other site
329726000621	Mg2+ binding site [ion binding]; other site
329726000622	G-X-G motif; other site
329726000623	Response regulator receiver domain; Region: Response_reg; pfam00072
329726000624	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726000625	active site
329726000626	phosphorylation site [posttranslational modification]
329726000627	intermolecular recognition site; other site
329726000628	dimerization interface [polypeptide binding]; other site
329726000629	FOG: CBS domain [General function prediction only]; Region: COG0517
329726000630	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
329726000631	PAS fold; Region: PAS_4; pfam08448
329726000632	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726000633	dimer interface [polypeptide binding]; other site
329726000634	phosphorylation site [posttranslational modification]
329726000635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726000636	ATP binding site [chemical binding]; other site
329726000637	Mg2+ binding site [ion binding]; other site
329726000638	G-X-G motif; other site
329726000639	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
329726000640	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
329726000641	active site
329726000642	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
329726000643	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
329726000644	putative tRNA-binding site [nucleotide binding]; other site
329726000645	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
329726000646	putative ADP-ribose binding site [chemical binding]; other site
329726000647	putative active site [active]
329726000648	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
329726000649	Active_site [active]
329726000650	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
329726000651	metal ion-dependent adhesion site (MIDAS); other site
329726000652	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726000653	putative active site [active]
329726000654	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
329726000655	ATP binding site [chemical binding]; other site
329726000656	substrate interface [chemical binding]; other site
329726000657	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
329726000658	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
329726000659	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
329726000660	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
329726000661	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
329726000662	Iron permease FTR1 family; Region: FTR1; cl00475
329726000663	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726000664	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726000665	Caspase domain; Region: Peptidase_C14; pfam00656
329726000666	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726000667	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726000668	hypothetical protein; Region: PHA00652
329726000669	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
329726000670	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726000671	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
329726000672	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
329726000673	putative active site [active]
329726000674	putative NTP binding site [chemical binding]; other site
329726000675	putative nucleic acid binding site [nucleotide binding]; other site
329726000676	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
329726000677	MoaE interaction surface [polypeptide binding]; other site
329726000678	MoeB interaction surface [polypeptide binding]; other site
329726000679	thiocarboxylated glycine; other site
329726000680	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
329726000681	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
329726000682	Active Sites [active]
329726000683	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726000684	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726000685	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726000686	Homeodomain-like domain; Region: HTH_23; pfam13384
329726000687	Winged helix-turn helix; Region: HTH_29; pfam13551
329726000688	Winged helix-turn helix; Region: HTH_33; pfam13592
329726000689	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
329726000690	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
329726000691	PBP superfamily domain; Region: PBP_like_2; pfam12849
329726000692	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
329726000693	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
329726000694	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
329726000695	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
329726000696	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
329726000697	putative efflux protein, MATE family; Region: matE; TIGR00797
329726000698	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
329726000699	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
329726000700	glutaminase A; Region: Gln_ase; TIGR03814
329726000701	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726000702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726000703	S-adenosylmethionine binding site [chemical binding]; other site
329726000704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726000705	S-adenosylmethionine binding site [chemical binding]; other site
329726000706	Methyltransferase domain; Region: Methyltransf_24; pfam13578
329726000707	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
329726000708	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
329726000709	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
329726000710	putative metal binding site; other site
329726000711	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726000712	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
329726000713	putative ADP-binding pocket [chemical binding]; other site
329726000714	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
329726000715	active site
329726000716	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
329726000717	Ligand Binding Site [chemical binding]; other site
329726000718	Molecular Tunnel; other site
329726000719	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726000720	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
329726000721	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726000722	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726000723	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
329726000724	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726000725	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726000726	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
329726000727	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726000728	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
329726000729	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726000730	Walker A/P-loop; other site
329726000731	ATP binding site [chemical binding]; other site
329726000732	Q-loop/lid; other site
329726000733	ABC transporter signature motif; other site
329726000734	Walker B; other site
329726000735	D-loop; other site
329726000736	H-loop/switch region; other site
329726000737	putative glycosyl transferase; Provisional; Region: PRK10307
329726000738	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
329726000739	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
329726000740	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
329726000741	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
329726000742	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726000743	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726000744	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
329726000745	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
329726000746	putative NAD(P) binding site [chemical binding]; other site
329726000747	active site
329726000748	putative substrate binding site [chemical binding]; other site
329726000749	Response regulator receiver domain; Region: Response_reg; pfam00072
329726000750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726000751	active site
329726000752	phosphorylation site [posttranslational modification]
329726000753	intermolecular recognition site; other site
329726000754	dimerization interface [polypeptide binding]; other site
329726000755	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
329726000756	PAS domain S-box; Region: sensory_box; TIGR00229
329726000757	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726000758	putative active site [active]
329726000759	heme pocket [chemical binding]; other site
329726000760	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
329726000761	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726000762	putative active site [active]
329726000763	heme pocket [chemical binding]; other site
329726000764	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726000765	dimer interface [polypeptide binding]; other site
329726000766	phosphorylation site [posttranslational modification]
329726000767	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726000768	ATP binding site [chemical binding]; other site
329726000769	Mg2+ binding site [ion binding]; other site
329726000770	G-X-G motif; other site
329726000771	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
329726000772	putative active site [active]
329726000773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
329726000774	Protein of unknown function, DUF482; Region: DUF482; pfam04339
329726000775	SEC-C motif; Region: SEC-C; pfam02810
329726000776	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
329726000777	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
329726000778	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
329726000779	active site
329726000780	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
329726000781	Clp amino terminal domain; Region: Clp_N; pfam02861
329726000782	Clp amino terminal domain; Region: Clp_N; pfam02861
329726000783	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726000784	Walker A motif; other site
329726000785	ATP binding site [chemical binding]; other site
329726000786	Walker B motif; other site
329726000787	arginine finger; other site
329726000788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726000789	Walker A motif; other site
329726000790	ATP binding site [chemical binding]; other site
329726000791	Walker B motif; other site
329726000792	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
329726000793	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
329726000794	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
329726000795	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
329726000796	substrate binding site; other site
329726000797	tetramer interface; other site
329726000798	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
329726000799	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
329726000800	NAD binding site [chemical binding]; other site
329726000801	substrate binding site [chemical binding]; other site
329726000802	homodimer interface [polypeptide binding]; other site
329726000803	active site
329726000804	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
329726000805	ligand-binding site [chemical binding]; other site
329726000806	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
329726000807	Chain length determinant protein; Region: Wzz; pfam02706
329726000808	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
329726000809	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
329726000810	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726000811	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
329726000812	DNA methylase; Region: N6_N4_Mtase; pfam01555
329726000813	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
329726000814	active site
329726000815	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
329726000816	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
329726000817	active site
329726000818	substrate binding site [chemical binding]; other site
329726000819	Mg2+ binding site [ion binding]; other site
329726000820	diaminopimelate decarboxylase; Region: lysA; TIGR01048
329726000821	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
329726000822	active site
329726000823	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
329726000824	substrate binding site [chemical binding]; other site
329726000825	catalytic residues [active]
329726000826	dimer interface [polypeptide binding]; other site
329726000827	Uncharacterized conserved protein [Function unknown]; Region: COG1624
329726000828	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
329726000829	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
329726000830	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
329726000831	catalytic residue [active]
329726000832	putative FPP diphosphate  binding site; other site
329726000833	putative FPP binding hydrophobic cleft; other site
329726000834	dimer interface [polypeptide binding]; other site
329726000835	putative IPP diphosphate binding site; other site
329726000836	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
329726000837	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
329726000838	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
329726000839	HSP70 interaction site [polypeptide binding]; other site
329726000840	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
329726000841	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
329726000842	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
329726000843	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
329726000844	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
329726000845	Walker A motif; other site
329726000846	ATP binding site [chemical binding]; other site
329726000847	Walker B motif; other site
329726000848	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
329726000849	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
329726000850	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
329726000851	Walker A motif; other site
329726000852	ATP binding site [chemical binding]; other site
329726000853	Walker B motif; other site
329726000854	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
329726000855	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
329726000856	dimer interface [polypeptide binding]; other site
329726000857	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
329726000858	molecular chaperone DnaK; Provisional; Region: PRK13411
329726000859	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
329726000860	nucleotide binding site [chemical binding]; other site
329726000861	NEF interaction site [polypeptide binding]; other site
329726000862	SBD interface [polypeptide binding]; other site
329726000863	chaperone protein DnaJ; Provisional; Region: PRK14293
329726000864	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
329726000865	HSP70 interaction site [polypeptide binding]; other site
329726000866	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
329726000867	Zn binding sites [ion binding]; other site
329726000868	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
329726000869	dimer interface [polypeptide binding]; other site
329726000870	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
329726000871	CPxP  motif; other site
329726000872	GTPase RsgA; Reviewed; Region: PRK12289
329726000873	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
329726000874	RNA binding site [nucleotide binding]; other site
329726000875	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
329726000876	GTPase/Zn-binding domain interface [polypeptide binding]; other site
329726000877	GTP/Mg2+ binding site [chemical binding]; other site
329726000878	G4 box; other site
329726000879	G5 box; other site
329726000880	G1 box; other site
329726000881	Switch I region; other site
329726000882	G2 box; other site
329726000883	G3 box; other site
329726000884	Switch II region; other site
329726000885	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
329726000886	putative hydrophobic ligand binding site [chemical binding]; other site
329726000887	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
329726000888	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726000889	motif II; other site
329726000890	Repair protein; Region: Repair_PSII; pfam04536
329726000891	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
329726000892	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
329726000893	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
329726000894	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
329726000895	dimerization interface [polypeptide binding]; other site
329726000896	putative ATP binding site [chemical binding]; other site
329726000897	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
329726000898	Walker B motif; other site
329726000899	Uncharacterized conserved protein [Function unknown]; Region: COG3937
329726000900	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726000901	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726000902	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726000903	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
329726000904	active site
329726000905	catalytic residues [active]
329726000906	Int/Topo IB signature motif; other site
329726000907	DNA binding site [nucleotide binding]
329726000908	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
329726000909	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
329726000910	CoA binding domain; Region: CoA_binding_2; pfam13380
329726000911	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
329726000912	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
329726000913	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726000914	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
329726000915	Pyruvate formate lyase 1; Region: PFL1; cd01678
329726000916	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
329726000917	coenzyme A binding site [chemical binding]; other site
329726000918	active site
329726000919	catalytic residues [active]
329726000920	glycine loop; other site
329726000921	phosphoenolpyruvate synthase; Validated; Region: PRK06464
329726000922	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
329726000923	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
329726000924	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
329726000925	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
329726000926	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726000927	FeS/SAM binding site; other site
329726000928	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
329726000929	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
329726000930	putative catalytic cysteine [active]
329726000931	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
329726000932	putative active site [active]
329726000933	metal binding site [ion binding]; metal-binding site
329726000934	putative phosphoketolase; Provisional; Region: PRK05261
329726000935	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
329726000936	TPP-binding site; other site
329726000937	XFP C-terminal domain; Region: XFP_C; pfam09363
329726000938	pyruvate kinase; Provisional; Region: PRK14725
329726000939	active site
329726000940	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
329726000941	propionate/acetate kinase; Provisional; Region: PRK12379
329726000942	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726000943	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726000944	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726000945	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
329726000946	pheophytin binding site; other site
329726000947	chlorophyll binding site; other site
329726000948	quinone binding site; other site
329726000949	Fe binding site [ion binding]; other site
329726000950	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
329726000951	active site residue [active]
329726000952	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
329726000953	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
329726000954	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
329726000955	iron-sulfur cluster [ion binding]; other site
329726000956	[2Fe-2S] cluster binding site [ion binding]; other site
329726000957	Putative phosphatase (DUF442); Region: DUF442; cl17385
329726000958	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
329726000959	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
329726000960	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
329726000961	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
329726000962	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726000963	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
329726000964	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726000965	FeS/SAM binding site; other site
329726000966	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
329726000967	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
329726000968	FMN binding site [chemical binding]; other site
329726000969	substrate binding site [chemical binding]; other site
329726000970	putative catalytic residue [active]
329726000971	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
329726000972	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726000973	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726000974	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726000975	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726000976	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726000977	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
329726000978	dimerization interface [polypeptide binding]; other site
329726000979	putative DNA binding site [nucleotide binding]; other site
329726000980	putative Zn2+ binding site [ion binding]; other site
329726000981	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726000982	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726000983	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726000984	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726000985	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726000986	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726000987	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
329726000988	diiron binding motif [ion binding]; other site
329726000989	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
329726000990	heme binding pocket [chemical binding]; other site
329726000991	heme ligand [chemical binding]; other site
329726000992	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
329726000993	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726000994	FeS/SAM binding site; other site
329726000995	HemN C-terminal domain; Region: HemN_C; pfam06969
329726000996	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
329726000997	nudix motif; other site
329726000998	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726000999	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726001000	putative active site [active]
329726001001	heme pocket [chemical binding]; other site
329726001002	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726001003	putative active site [active]
329726001004	heme pocket [chemical binding]; other site
329726001005	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726001006	dimer interface [polypeptide binding]; other site
329726001007	phosphorylation site [posttranslational modification]
329726001008	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726001009	ATP binding site [chemical binding]; other site
329726001010	Mg2+ binding site [ion binding]; other site
329726001011	G-X-G motif; other site
329726001012	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726001013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726001014	active site
329726001015	phosphorylation site [posttranslational modification]
329726001016	intermolecular recognition site; other site
329726001017	dimerization interface [polypeptide binding]; other site
329726001018	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
329726001019	Protein export membrane protein; Region: SecD_SecF; cl14618
329726001020	Protein export membrane protein; Region: SecD_SecF; cl14618
329726001021	FeoC like transcriptional regulator; Region: FeoC; pfam09012
329726001022	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
329726001023	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
329726001024	G1 box; other site
329726001025	GTP/Mg2+ binding site [chemical binding]; other site
329726001026	Switch I region; other site
329726001027	G2 box; other site
329726001028	G3 box; other site
329726001029	Switch II region; other site
329726001030	G4 box; other site
329726001031	G5 box; other site
329726001032	Nucleoside recognition; Region: Gate; pfam07670
329726001033	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
329726001034	Nucleoside recognition; Region: Gate; pfam07670
329726001035	FeoA domain; Region: FeoA; pfam04023
329726001036	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
329726001037	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
329726001038	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
329726001039	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726001040	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726001041	ligand binding site [chemical binding]; other site
329726001042	flexible hinge region; other site
329726001043	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
329726001044	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
329726001045	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
329726001046	apolar tunnel; other site
329726001047	heme binding site [chemical binding]; other site
329726001048	dimerization interface [polypeptide binding]; other site
329726001049	Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053
329726001050	diiron binding motif [ion binding]; other site
329726001051	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726001052	DDE superfamily endonuclease; Region: DDE_5; cl17874
329726001053	Transposase; Region: HTH_Tnp_IS630; pfam01710
329726001054	Helix-turn-helix domain; Region: HTH_28; pfam13518
329726001055	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726001056	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726001057	Homeodomain-like domain; Region: HTH_23; pfam13384
329726001058	Winged helix-turn helix; Region: HTH_29; pfam13551
329726001059	Homeodomain-like domain; Region: HTH_32; pfam13565
329726001060	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726001061	Integrase core domain; Region: rve; pfam00665
329726001062	DDE domain; Region: DDE_Tnp_IS240; pfam13610
329726001063	Integrase core domain; Region: rve_3; pfam13683
329726001064	HTH-like domain; Region: HTH_21; pfam13276
329726001065	transposase; Validated; Region: PRK08181
329726001066	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726001067	Walker A motif; other site
329726001068	ATP binding site [chemical binding]; other site
329726001069	Integrase core domain; Region: rve; pfam00665
329726001070	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726001071	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726001072	Transposase; Region: HTH_Tnp_IS630; pfam01710
329726001073	Helix-turn-helix domain; Region: HTH_28; pfam13518
329726001074	CAAX protease self-immunity; Region: Abi; cl00558
329726001075	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
329726001076	Transposase domain (DUF772); Region: DUF772; pfam05598
329726001077	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726001078	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
329726001079	Catalytic site [active]
329726001080	Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055
329726001081	Protein of unknown function (DUF2753); Region: DUF2753; pfam10952
329726001082	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
329726001083	MPN+ (JAMM) motif; other site
329726001084	Zinc-binding site [ion binding]; other site
329726001085	hypothetical protein; Validated; Region: PRK07411
329726001086	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
329726001087	ATP binding site [chemical binding]; other site
329726001088	substrate interface [chemical binding]; other site
329726001089	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
329726001090	active site residue [active]
329726001091	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726001092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726001093	active site
329726001094	phosphorylation site [posttranslational modification]
329726001095	intermolecular recognition site; other site
329726001096	dimerization interface [polypeptide binding]; other site
329726001097	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726001098	DNA binding residues [nucleotide binding]
329726001099	dimerization interface [polypeptide binding]; other site
329726001100	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
329726001101	Histidine kinase; Region: HisKA_3; pfam07730
329726001102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726001103	ATP binding site [chemical binding]; other site
329726001104	Mg2+ binding site [ion binding]; other site
329726001105	G-X-G motif; other site
329726001106	Bacterial sugar transferase; Region: Bac_transf; pfam02397
329726001107	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
329726001108	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
329726001109	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
329726001110	Cache domain; Region: Cache_1; pfam02743
329726001111	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726001112	dimerization interface [polypeptide binding]; other site
329726001113	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726001114	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726001115	metal binding site [ion binding]; metal-binding site
329726001116	active site
329726001117	I-site; other site
329726001118	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726001119	Amidinotransferase; Region: Amidinotransf; cl12043
329726001120	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
329726001121	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
329726001122	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
329726001123	substrate binding pocket [chemical binding]; other site
329726001124	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
329726001125	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726001126	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726001127	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726001128	DNA binding residues [nucleotide binding]
329726001129	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326
329726001130	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
329726001131	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
329726001132	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
329726001133	Family of unknown function (DUF490); Region: DUF490; pfam04357
329726001134	Family of unknown function (DUF490); Region: DUF490; pfam04357
329726001135	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
329726001136	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
329726001137	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
329726001138	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
329726001139	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726001140	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
329726001141	Walker A motif; other site
329726001142	ATP binding site [chemical binding]; other site
329726001143	Walker B motif; other site
329726001144	arginine finger; other site
329726001145	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
329726001146	metal ion-dependent adhesion site (MIDAS); other site
329726001147	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726001148	Transposase domain (DUF772); Region: DUF772; pfam05598
329726001149	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726001150	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
329726001151	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
329726001152	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
329726001153	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726001154	dimerization interface [polypeptide binding]; other site
329726001155	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726001156	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726001157	metal binding site [ion binding]; metal-binding site
329726001158	active site
329726001159	I-site; other site
329726001160	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726001161	GAF domain; Region: GAF_3; pfam13492
329726001162	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726001163	GAF domain; Region: GAF; pfam01590
329726001164	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726001165	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726001166	metal binding site [ion binding]; metal-binding site
329726001167	active site
329726001168	I-site; other site
329726001169	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726001170	glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482
329726001171	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
329726001172	inhibitor-cofactor binding pocket; inhibition site
329726001173	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726001174	catalytic residue [active]
329726001175	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
329726001176	PLD-like domain; Region: PLDc_2; pfam13091
329726001177	putative active site [active]
329726001178	catalytic site [active]
329726001179	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
329726001180	PLD-like domain; Region: PLDc_2; pfam13091
329726001181	putative active site [active]
329726001182	catalytic site [active]
329726001183	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
329726001184	Helix-hairpin-helix motif; Region: HHH; pfam00633
329726001185	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
329726001186	putative amphipathic alpha helix; other site
329726001187	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
329726001188	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
329726001189	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
329726001190	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726001191	P-loop; other site
329726001192	Magnesium ion binding site [ion binding]; other site
329726001193	Transcriptional regulator [Transcription]; Region: LysR; COG0583
329726001194	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726001195	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
329726001196	putative dimerization interface [polypeptide binding]; other site
329726001197	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
329726001198	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
329726001199	Peptidase family M48; Region: Peptidase_M48; cl12018
329726001200	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
329726001201	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
329726001202	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
329726001203	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
329726001204	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726001205	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726001206	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726001207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726001208	active site
329726001209	phosphorylation site [posttranslational modification]
329726001210	intermolecular recognition site; other site
329726001211	dimerization interface [polypeptide binding]; other site
329726001212	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726001213	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726001214	metal binding site [ion binding]; metal-binding site
329726001215	active site
329726001216	I-site; other site
329726001217	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
329726001218	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
329726001219	active site
329726001220	dimer interface [polypeptide binding]; other site
329726001221	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
329726001222	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
329726001223	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
329726001224	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
329726001225	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726001226	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
329726001227	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726001228	active site
329726001229	metal binding site [ion binding]; metal-binding site
329726001230	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726001231	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726001232	maltose O-acetyltransferase; Provisional; Region: PRK10092
329726001233	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
329726001234	active site
329726001235	substrate binding site [chemical binding]; other site
329726001236	trimer interface [polypeptide binding]; other site
329726001237	CoA binding site [chemical binding]; other site
329726001238	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726001239	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
329726001240	H+ Antiporter protein; Region: 2A0121; TIGR00900
329726001241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726001242	putative substrate translocation pore; other site
329726001243	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
329726001244	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726001245	Coenzyme A binding pocket [chemical binding]; other site
329726001246	PAS fold; Region: PAS_3; pfam08447
329726001247	PAS domain S-box; Region: sensory_box; TIGR00229
329726001248	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726001249	putative active site [active]
329726001250	heme pocket [chemical binding]; other site
329726001251	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726001252	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726001253	metal binding site [ion binding]; metal-binding site
329726001254	active site
329726001255	I-site; other site
329726001256	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726001257	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726001258	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726001259	phosphopeptide binding site; other site
329726001260	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
329726001261	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
329726001262	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
329726001263	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
329726001264	active site
329726001265	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
329726001266	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
329726001267	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
329726001268	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
329726001269	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
329726001270	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
329726001271	Surface antigen; Region: Bac_surface_Ag; pfam01103
329726001272	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
329726001273	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
329726001274	ATP binding site [chemical binding]; other site
329726001275	active site
329726001276	substrate binding site [chemical binding]; other site
329726001277	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
329726001278	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
329726001279	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
329726001280	active site
329726001281	KWG Leptospira; Region: KWG; pfam07656
329726001282	KWG Leptospira; Region: KWG; pfam07656
329726001283	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
329726001284	transmembrane helices; other site
329726001285	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
329726001286	TrkA-C domain; Region: TrkA_C; pfam02080
329726001287	TrkA-C domain; Region: TrkA_C; pfam02080
329726001288	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
329726001289	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
329726001290	Low molecular weight phosphatase family; Region: LMWPc; cd00115
329726001291	active site
329726001292	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
329726001293	arsenical-resistance protein; Region: acr3; TIGR00832
329726001294	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
329726001295	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
329726001296	DNA binding residues [nucleotide binding]
329726001297	dimer interface [polypeptide binding]; other site
329726001298	metal binding site [ion binding]; metal-binding site
329726001299	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726001300	Methyltransferase domain; Region: Methyltransf_18; pfam12847
329726001301	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
329726001302	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
329726001303	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
329726001304	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
329726001305	TPR repeat; Region: TPR_11; pfam13414
329726001306	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726001307	binding surface
329726001308	TPR motif; other site
329726001309	TPR repeat; Region: TPR_11; pfam13414
329726001310	TPR repeat; Region: TPR_11; pfam13414
329726001311	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726001312	binding surface
329726001313	TPR motif; other site
329726001314	TPR repeat; Region: TPR_11; pfam13414
329726001315	TPR repeat; Region: TPR_11; pfam13414
329726001316	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726001317	TPR motif; other site
329726001318	binding surface
329726001319	TPR repeat; Region: TPR_11; pfam13414
329726001320	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
329726001321	elongation factor G; Reviewed; Region: PRK12740
329726001322	G1 box; other site
329726001323	putative GEF interaction site [polypeptide binding]; other site
329726001324	GTP/Mg2+ binding site [chemical binding]; other site
329726001325	Switch I region; other site
329726001326	G2 box; other site
329726001327	G3 box; other site
329726001328	Switch II region; other site
329726001329	G4 box; other site
329726001330	G5 box; other site
329726001331	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
329726001332	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
329726001333	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
329726001334	glutamate racemase; Provisional; Region: PRK00865
329726001335	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
329726001336	active site
329726001337	thiamine monophosphate kinase; Provisional; Region: PRK05731
329726001338	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
329726001339	ATP binding site [chemical binding]; other site
329726001340	dimerization interface [polypeptide binding]; other site
329726001341	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
329726001342	Cytochrome P450; Region: p450; pfam00067
329726001343	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
329726001344	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726001345	binding surface
329726001346	Tetratricopeptide repeat; Region: TPR_16; pfam13432
329726001347	TPR motif; other site
329726001348	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
329726001349	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
329726001350	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
329726001351	dimerization interface [polypeptide binding]; other site
329726001352	active site
329726001353	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
329726001354	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
329726001355	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
329726001356	PsbP; Region: PsbP; pfam01789
329726001357	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
329726001358	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
329726001359	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
329726001360	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
329726001361	YCII-related domain; Region: YCII; cl00999
329726001362	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
329726001363	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
329726001364	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
329726001365	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
329726001366	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
329726001367	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
329726001368	active site
329726001369	homodimer interface [polypeptide binding]; other site
329726001370	catalytic site [active]
329726001371	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726001372	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726001373	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
329726001374	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
329726001375	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
329726001376	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
329726001377	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
329726001378	active site
329726001379	catalytic triad [active]
329726001380	Transcriptional regulator [Transcription]; Region: LysR; COG0583
329726001381	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726001382	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
329726001383	putative effector binding pocket; other site
329726001384	dimerization interface [polypeptide binding]; other site
329726001385	Pirin-related protein [General function prediction only]; Region: COG1741
329726001386	Pirin; Region: Pirin; pfam02678
329726001387	Heme NO binding; Region: HNOB; pfam07700
329726001388	Heme NO binding associated; Region: HNOBA; pfam07701
329726001389	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726001390	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726001391	dimer interface [polypeptide binding]; other site
329726001392	phosphorylation site [posttranslational modification]
329726001393	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726001394	ATP binding site [chemical binding]; other site
329726001395	Mg2+ binding site [ion binding]; other site
329726001396	G-X-G motif; other site
329726001397	Response regulator receiver domain; Region: Response_reg; pfam00072
329726001398	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726001399	active site
329726001400	phosphorylation site [posttranslational modification]
329726001401	intermolecular recognition site; other site
329726001402	dimerization interface [polypeptide binding]; other site
329726001403	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726001404	Ligand Binding Site [chemical binding]; other site
329726001405	Phosphoglycerate kinase; Region: PGK; pfam00162
329726001406	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
329726001407	substrate binding site [chemical binding]; other site
329726001408	hinge regions; other site
329726001409	ADP binding site [chemical binding]; other site
329726001410	catalytic site [active]
329726001411	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
329726001412	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
329726001413	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
329726001414	dimer interface [polypeptide binding]; other site
329726001415	motif 1; other site
329726001416	active site
329726001417	motif 2; other site
329726001418	motif 3; other site
329726001419	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
329726001420	anticodon binding site; other site
329726001421	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
329726001422	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
329726001423	HlyD family secretion protein; Region: HlyD; pfam00529
329726001424	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
329726001425	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726001426	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
329726001427	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
329726001428	FtsX-like permease family; Region: FtsX; pfam02687
329726001429	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
329726001430	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
329726001431	Walker A/P-loop; other site
329726001432	ATP binding site [chemical binding]; other site
329726001433	Q-loop/lid; other site
329726001434	ABC transporter signature motif; other site
329726001435	Walker B; other site
329726001436	D-loop; other site
329726001437	H-loop/switch region; other site
329726001438	endonuclease VIII; Provisional; Region: PRK10445
329726001439	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
329726001440	DNA binding site [nucleotide binding]
329726001441	catalytic residue [active]
329726001442	putative catalytic residues [active]
329726001443	H2TH interface [polypeptide binding]; other site
329726001444	intercalation triad [nucleotide binding]; other site
329726001445	substrate specificity determining residue; other site
329726001446	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
329726001447	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
329726001448	putative phosphate acyltransferase; Provisional; Region: PRK05331
329726001449	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
329726001450	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
329726001451	dimer interface [polypeptide binding]; other site
329726001452	active site
329726001453	CoA binding pocket [chemical binding]; other site
329726001454	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
329726001455	EamA-like transporter family; Region: EamA; pfam00892
329726001456	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
329726001457	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
329726001458	Hexamer interface [polypeptide binding]; other site
329726001459	Hexagonal pore residue; other site
329726001460	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
329726001461	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
329726001462	Hexamer interface [polypeptide binding]; other site
329726001463	Hexagonal pore residue; other site
329726001464	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
329726001465	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726001466	Walker A/P-loop; other site
329726001467	ATP binding site [chemical binding]; other site
329726001468	Q-loop/lid; other site
329726001469	ABC transporter signature motif; other site
329726001470	Walker B; other site
329726001471	D-loop; other site
329726001472	H-loop/switch region; other site
329726001473	Uncharacterized conserved protein [Function unknown]; Region: COG4279
329726001474	SWIM zinc finger; Region: SWIM; pfam04434
329726001475	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726001476	putative active site [active]
329726001477	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
329726001478	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
329726001479	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
329726001480	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
329726001481	SNF2 Helicase protein; Region: DUF3670; pfam12419
329726001482	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726001483	ATP binding site [chemical binding]; other site
329726001484	putative Mg++ binding site [ion binding]; other site
329726001485	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726001486	nucleotide binding region [chemical binding]; other site
329726001487	ATP-binding site [chemical binding]; other site
329726001488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726001489	putative PBP binding loops; other site
329726001490	dimer interface [polypeptide binding]; other site
329726001491	ABC-ATPase subunit interface; other site
329726001492	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
329726001493	HSP70 interaction site [polypeptide binding]; other site
329726001494	TPR repeat; Region: TPR_11; pfam13414
329726001495	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726001496	binding surface
329726001497	TPR motif; other site
329726001498	TPR repeat; Region: TPR_11; pfam13414
329726001499	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726001500	binding surface
329726001501	TPR motif; other site
329726001502	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
329726001503	Peptidase family M50; Region: Peptidase_M50; pfam02163
329726001504	active site
329726001505	putative substrate binding region [chemical binding]; other site
329726001506	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726001507	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726001508	binding surface
329726001509	TPR motif; other site
329726001510	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726001511	binding surface
329726001512	TPR motif; other site
329726001513	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726001514	binding surface
329726001515	TPR motif; other site
329726001516	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
329726001517	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
329726001518	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
329726001519	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
329726001520	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726001521	ATP binding site [chemical binding]; other site
329726001522	putative Mg++ binding site [ion binding]; other site
329726001523	nucleotide binding region [chemical binding]; other site
329726001524	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
329726001525	ATP-binding site [chemical binding]; other site
329726001526	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
329726001527	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
329726001528	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
329726001529	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
329726001530	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
329726001531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
329726001532	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726001533	HsdM N-terminal domain; Region: HsdM_N; pfam12161
329726001534	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
329726001535	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
329726001536	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
329726001537	oligomeric interface; other site
329726001538	putative active site [active]
329726001539	homodimer interface [polypeptide binding]; other site
329726001540	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
329726001541	putative active site [active]
329726001542	Putative phosphatase (DUF442); Region: DUF442; cl17385
329726001543	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
329726001544	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
329726001545	Peptidase family M50; Region: Peptidase_M50; pfam02163
329726001546	active site
329726001547	putative substrate binding region [chemical binding]; other site
329726001548	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
329726001549	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
329726001550	Protein export membrane protein; Region: SecD_SecF; pfam02355
329726001551	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
329726001552	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
329726001553	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
329726001554	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
329726001555	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
329726001556	alpha subunit interface [polypeptide binding]; other site
329726001557	TPP binding site [chemical binding]; other site
329726001558	heterodimer interface [polypeptide binding]; other site
329726001559	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
329726001560	photolyase PhrII; Region: phr2; TIGR00591
329726001561	DNA photolyase; Region: DNA_photolyase; pfam00875
329726001562	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
329726001563	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
329726001564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726001565	S-adenosylmethionine binding site [chemical binding]; other site
329726001566	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
329726001567	catalytic motif [active]
329726001568	Catalytic residue [active]
329726001569	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
329726001570	catalytic motif [active]
329726001571	Catalytic residue [active]
329726001572	GUN4-like; Region: GUN4; pfam05419
329726001573	CHASE2 domain; Region: CHASE2; pfam05226
329726001574	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
329726001575	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
329726001576	cyclase homology domain; Region: CHD; cd07302
329726001577	nucleotidyl binding site; other site
329726001578	metal binding site [ion binding]; metal-binding site
329726001579	dimer interface [polypeptide binding]; other site
329726001580	Uncharacterized conserved protein [Function unknown]; Region: COG1432
329726001581	LabA_like proteins; Region: LabA; cd10911
329726001582	putative metal binding site [ion binding]; other site
329726001583	2-isopropylmalate synthase; Validated; Region: PRK00915
329726001584	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
329726001585	active site
329726001586	catalytic residues [active]
329726001587	metal binding site [ion binding]; metal-binding site
329726001588	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
329726001589	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726001590	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726001591	Transposase, Mutator family; Region: Transposase_mut; pfam00872
329726001592	MULE transposase domain; Region: MULE; pfam10551
329726001593	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726001594	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
329726001595	PLD-like domain; Region: PLDc_2; pfam13091
329726001596	putative active site [active]
329726001597	catalytic site [active]
329726001598	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
329726001599	PLD-like domain; Region: PLDc_2; pfam13091
329726001600	putative active site [active]
329726001601	catalytic site [active]
329726001602	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726001603	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726001604	ligand binding site [chemical binding]; other site
329726001605	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726001606	CHAT domain; Region: CHAT; cl17868
329726001607	TIR domain; Region: TIR_2; pfam13676
329726001608	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
329726001609	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
329726001610	ATP binding site [chemical binding]; other site
329726001611	Walker A motif; other site
329726001612	Walker B motif; other site
329726001613	TolA protein; Region: tolA_full; TIGR02794
329726001614	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
329726001615	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726001616	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726001617	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
329726001618	putative active site [active]
329726001619	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
329726001620	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
329726001621	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
329726001622	acyl-activating enzyme (AAE) consensus motif; other site
329726001623	active site
329726001624	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
329726001625	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
329726001626	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
329726001627	acyl-CoA synthetase; Validated; Region: PRK05850
329726001628	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
329726001629	acyl-activating enzyme (AAE) consensus motif; other site
329726001630	active site
329726001631	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
329726001632	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
329726001633	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
329726001634	substrate-cofactor binding pocket; other site
329726001635	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726001636	catalytic residue [active]
329726001637	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
329726001638	catalytic core [active]
329726001639	3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939
329726001640	short chain dehydrogenase; Provisional; Region: PRK06181
329726001641	putative NAD(P) binding site [chemical binding]; other site
329726001642	homotetramer interface [polypeptide binding]; other site
329726001643	active site
329726001644	homodimer interface [polypeptide binding]; other site
329726001645	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
329726001646	DNA methylase; Region: N6_N4_Mtase; cl17433
329726001647	Cation efflux family; Region: Cation_efflux; cl00316
329726001648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
329726001649	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
329726001650	homotrimer interaction site [polypeptide binding]; other site
329726001651	putative active site [active]
329726001652	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
329726001653	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726001654	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
329726001655	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
329726001656	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
329726001657	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
329726001658	generic binding surface I; other site
329726001659	generic binding surface II; other site
329726001660	Haemolytic domain; Region: Haemolytic; pfam01809
329726001661	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
329726001662	aromatic amino acid transport protein; Region: araaP; TIGR00837
329726001663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
329726001664	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
329726001665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
329726001666	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
329726001667	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
329726001668	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
329726001669	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
329726001670	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
329726001671	homodimer interaction site [polypeptide binding]; other site
329726001672	cofactor binding site; other site
329726001673	Src Homology 3 domain superfamily; Region: SH3; cl17036
329726001674	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
329726001675	Leucine carboxyl methyltransferase; Region: LCM; cl01306
329726001676	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
329726001677	active site
329726001678	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726001679	Homeodomain-like domain; Region: HTH_23; pfam13384
329726001680	Winged helix-turn helix; Region: HTH_29; pfam13551
329726001681	Homeodomain-like domain; Region: HTH_32; pfam13565
329726001682	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
329726001683	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
329726001684	C-terminal domain interface [polypeptide binding]; other site
329726001685	GSH binding site (G-site) [chemical binding]; other site
329726001686	dimer interface [polypeptide binding]; other site
329726001687	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
329726001688	N-terminal domain interface [polypeptide binding]; other site
329726001689	dimer interface [polypeptide binding]; other site
329726001690	substrate binding pocket (H-site) [chemical binding]; other site
329726001691	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726001692	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726001693	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
329726001694	ATP-grasp domain; Region: ATP-grasp; pfam02222
329726001695	aspartate kinase; Provisional; Region: PRK07431
329726001696	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
329726001697	putative catalytic residues [active]
329726001698	putative nucleotide binding site [chemical binding]; other site
329726001699	putative aspartate binding site [chemical binding]; other site
329726001700	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
329726001701	putative allosteric regulatory site; other site
329726001702	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
329726001703	putative allosteric regulatory residue; other site
329726001704	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
329726001705	putative allosteric regulatory site; other site
329726001706	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
329726001707	putative allosteric regulatory residue; other site
329726001708	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726001709	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726001710	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726001711	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
329726001712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726001713	dimer interface [polypeptide binding]; other site
329726001714	conserved gate region; other site
329726001715	putative PBP binding loops; other site
329726001716	ABC-ATPase subunit interface; other site
329726001717	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726001718	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
329726001719	Walker A/P-loop; other site
329726001720	ATP binding site [chemical binding]; other site
329726001721	Q-loop/lid; other site
329726001722	ABC transporter signature motif; other site
329726001723	Walker B; other site
329726001724	D-loop; other site
329726001725	H-loop/switch region; other site
329726001726	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
329726001727	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
329726001728	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
329726001729	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
329726001730	nudix motif; other site
329726001731	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
329726001732	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
329726001733	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
329726001734	S-layer homology domain; Region: SLH; pfam00395
329726001735	S-layer homology domain; Region: SLH; pfam00395
329726001736	S-layer homology domain; Region: SLH; pfam00395
329726001737	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
329726001738	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
329726001739	FAD binding domain; Region: FAD_binding_4; pfam01565
329726001740	Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265
329726001741	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726001742	Coenzyme A binding pocket [chemical binding]; other site
329726001743	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
329726001744	ATP-NAD kinase; Region: NAD_kinase; pfam01513
329726001745	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
329726001746	Active_site [active]
329726001747	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
329726001748	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726001749	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726001750	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726001751	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726001752	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726001753	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726001754	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
329726001755	active site pocket [active]
329726001756	oxyanion hole [active]
329726001757	catalytic triad [active]
329726001758	active site nucleophile [active]
329726001759	hypothetical protein; Provisional; Region: PRK02509
329726001760	Uncharacterized conserved protein [Function unknown]; Region: COG1615
329726001761	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
329726001762	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
329726001763	FAD binding site [chemical binding]; other site
329726001764	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
329726001765	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726001766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726001767	active site
329726001768	phosphorylation site [posttranslational modification]
329726001769	intermolecular recognition site; other site
329726001770	dimerization interface [polypeptide binding]; other site
329726001771	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726001772	DNA binding site [nucleotide binding]
329726001773	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
329726001774	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
329726001775	Predicted flavoprotein [General function prediction only]; Region: COG0431
329726001776	Cation efflux family; Region: Cation_efflux; pfam01545
329726001777	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
329726001778	putative ADP-binding pocket [chemical binding]; other site
329726001779	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726001780	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
329726001781	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
329726001782	NADP binding site [chemical binding]; other site
329726001783	active site
329726001784	putative substrate binding site [chemical binding]; other site
329726001785	TMAO/DMSO reductase; Reviewed; Region: PRK05363
329726001786	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
329726001787	Moco binding site; other site
329726001788	metal coordination site [ion binding]; other site
329726001789	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
329726001790	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
329726001791	cell division protein FtsZ; Validated; Region: PRK09330
329726001792	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
329726001793	nucleotide binding site [chemical binding]; other site
329726001794	SulA interaction site; other site
329726001795	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
329726001796	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
329726001797	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
329726001798	active site
329726001799	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
329726001800	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
329726001801	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
329726001802	Walker A/P-loop; other site
329726001803	ATP binding site [chemical binding]; other site
329726001804	Q-loop/lid; other site
329726001805	ABC transporter signature motif; other site
329726001806	Walker B; other site
329726001807	D-loop; other site
329726001808	H-loop/switch region; other site
329726001809	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
329726001810	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
329726001811	putative switch regulator; other site
329726001812	non-specific DNA interactions [nucleotide binding]; other site
329726001813	DNA binding site [nucleotide binding]
329726001814	sequence specific DNA binding site [nucleotide binding]; other site
329726001815	putative cAMP binding site [chemical binding]; other site
329726001816	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
329726001817	protein SRG1; Region: PLN02216
329726001818	Transposase domain (DUF772); Region: DUF772; pfam05598
329726001819	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726001820	Cytochrome P450; Region: p450; cl12078
329726001821	Lipoxygenase; Region: Lipoxygenase; pfam00305
329726001822	Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772
329726001823	catalytic residue [active]
329726001824	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726001825	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726001826	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726001827	active site
329726001828	DNA binding site [nucleotide binding]
329726001829	Int/Topo IB signature motif; other site
329726001830	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
329726001831	Fatty acid desaturase; Region: FA_desaturase; pfam00487
329726001832	Di-iron ligands [ion binding]; other site
329726001833	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
329726001834	GSH binding site [chemical binding]; other site
329726001835	catalytic residues [active]
329726001836	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726001837	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726001838	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726001839	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726001840	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726001841	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726001842	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726001843	Cytochrome P450; Region: p450; pfam00067
329726001844	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
329726001845	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
329726001846	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
329726001847	HSP70 interaction site [polypeptide binding]; other site
329726001848	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726001849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726001850	active site
329726001851	phosphorylation site [posttranslational modification]
329726001852	intermolecular recognition site; other site
329726001853	dimerization interface [polypeptide binding]; other site
329726001854	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726001855	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726001856	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726001857	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726001858	putative active site [active]
329726001859	heme pocket [chemical binding]; other site
329726001860	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
329726001861	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726001862	putative active site [active]
329726001863	heme pocket [chemical binding]; other site
329726001864	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726001865	dimer interface [polypeptide binding]; other site
329726001866	phosphorylation site [posttranslational modification]
329726001867	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726001868	ATP binding site [chemical binding]; other site
329726001869	Mg2+ binding site [ion binding]; other site
329726001870	G-X-G motif; other site
329726001871	hypothetical protein; Validated; Region: PRK07413
329726001872	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
329726001873	Walker A motif; other site
329726001874	homodimer interface [polypeptide binding]; other site
329726001875	ATP binding site [chemical binding]; other site
329726001876	hydroxycobalamin binding site [chemical binding]; other site
329726001877	Walker B motif; other site
329726001878	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
329726001879	Walker A motif; other site
329726001880	homodimer interface [polypeptide binding]; other site
329726001881	ATP binding site [chemical binding]; other site
329726001882	hydroxycobalamin binding site [chemical binding]; other site
329726001883	Walker B motif; other site
329726001884	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
329726001885	cyclase homology domain; Region: CHD; cd07302
329726001886	nucleotidyl binding site; other site
329726001887	metal binding site [ion binding]; metal-binding site
329726001888	dimer interface [polypeptide binding]; other site
329726001889	AAA ATPase domain; Region: AAA_16; pfam13191
329726001890	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
329726001891	Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804
329726001892	Uncharacterized conserved protein [Function unknown]; Region: COG3349
329726001893	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726001894	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
329726001895	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
329726001896	substrate binding pocket [chemical binding]; other site
329726001897	chain length determination region; other site
329726001898	substrate-Mg2+ binding site; other site
329726001899	catalytic residues [active]
329726001900	aspartate-rich region 1; other site
329726001901	active site lid residues [active]
329726001902	aspartate-rich region 2; other site
329726001903	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
329726001904	4Fe-4S binding domain; Region: Fer4; pfam00037
329726001905	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
329726001906	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
329726001907	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
329726001908	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
329726001909	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
329726001910	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726001911	Homeodomain-like domain; Region: HTH_23; pfam13384
329726001912	Winged helix-turn helix; Region: HTH_29; pfam13551
329726001913	Homeodomain-like domain; Region: HTH_32; pfam13565
329726001914	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
329726001915	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
329726001916	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
329726001917	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
329726001918	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726001919	S-adenosylmethionine binding site [chemical binding]; other site
329726001920	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
329726001921	heme binding pocket [chemical binding]; other site
329726001922	heme ligand [chemical binding]; other site
329726001923	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
329726001924	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
329726001925	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
329726001926	catalytic residue [active]
329726001927	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
329726001928	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
329726001929	active site
329726001930	AIR carboxylase; Region: AIRC; pfam00731
329726001931	alanine racemase; Reviewed; Region: alr; PRK00053
329726001932	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
329726001933	active site
329726001934	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
329726001935	dimer interface [polypeptide binding]; other site
329726001936	substrate binding site [chemical binding]; other site
329726001937	catalytic residues [active]
329726001938	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
329726001939	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
329726001940	putative C-terminal domain interface [polypeptide binding]; other site
329726001941	putative GSH binding site (G-site) [chemical binding]; other site
329726001942	putative dimer interface [polypeptide binding]; other site
329726001943	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
329726001944	N-terminal domain interface [polypeptide binding]; other site
329726001945	dimer interface [polypeptide binding]; other site
329726001946	substrate binding pocket (H-site) [chemical binding]; other site
329726001947	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
329726001948	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
329726001949	Walker A/P-loop; other site
329726001950	ATP binding site [chemical binding]; other site
329726001951	Q-loop/lid; other site
329726001952	ABC transporter signature motif; other site
329726001953	Walker B; other site
329726001954	D-loop; other site
329726001955	H-loop/switch region; other site
329726001956	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
329726001957	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
329726001958	Walker A/P-loop; other site
329726001959	ATP binding site [chemical binding]; other site
329726001960	Q-loop/lid; other site
329726001961	ABC transporter signature motif; other site
329726001962	Walker B; other site
329726001963	D-loop; other site
329726001964	H-loop/switch region; other site
329726001965	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
329726001966	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
329726001967	TM-ABC transporter signature motif; other site
329726001968	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
329726001969	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
329726001970	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
329726001971	TM-ABC transporter signature motif; other site
329726001972	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
329726001973	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
329726001974	putative ligand binding site [chemical binding]; other site
329726001975	S-layer homology domain; Region: SLH; pfam00395
329726001976	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
329726001977	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726001978	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
329726001979	UreF; Region: UreF; pfam01730
329726001980	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
329726001981	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
329726001982	Transposase; Region: HTH_Tnp_1; cl17663
329726001983	putative transposase OrfB; Reviewed; Region: PHA02517
329726001984	HTH-like domain; Region: HTH_21; pfam13276
329726001985	Integrase core domain; Region: rve; pfam00665
329726001986	Integrase core domain; Region: rve_3; pfam13683
329726001987	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
329726001988	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
329726001989	dimer interface [polypeptide binding]; other site
329726001990	catalytic residues [active]
329726001991	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
329726001992	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
329726001993	Active Sites [active]
329726001994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726001995	S-adenosylmethionine binding site [chemical binding]; other site
329726001996	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
329726001997	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
329726001998	Domain of unknown function (DUF4033); Region: DUF4033; pfam13225
329726001999	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726002000	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726002001	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726002002	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726002003	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726002004	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726002005	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726002006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726002007	S-adenosylmethionine binding site [chemical binding]; other site
329726002008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
329726002009	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
329726002010	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
329726002011	Resolvase, N terminal domain; Region: Resolvase; smart00857
329726002012	catalytic residues [active]
329726002013	Recombinase; Region: Recombinase; pfam07508
329726002014	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
329726002015	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
329726002016	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
329726002017	ATP synthase I chain; Region: ATP_synt_I; pfam03899
329726002018	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
329726002019	ATP synthase CF0 A subunit; Region: atpI; CHL00046
329726002020	F0F1 ATP synthase subunit C; Validated; Region: PRK07354
329726002021	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
329726002022	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
329726002023	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
329726002024	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
329726002025	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
329726002026	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
329726002027	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
329726002028	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
329726002029	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
329726002030	beta subunit interaction interface [polypeptide binding]; other site
329726002031	Walker A motif; other site
329726002032	ATP binding site [chemical binding]; other site
329726002033	Walker B motif; other site
329726002034	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
329726002035	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
329726002036	core domain interface [polypeptide binding]; other site
329726002037	delta subunit interface [polypeptide binding]; other site
329726002038	epsilon subunit interface [polypeptide binding]; other site
329726002039	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
329726002040	tartrate dehydrogenase; Region: TTC; TIGR02089
329726002041	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726002042	putative active site [active]
329726002043	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726002044	putative active site [active]
329726002045	GTPase RsgA; Reviewed; Region: PRK01889
329726002046	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
329726002047	RNA binding site [nucleotide binding]; other site
329726002048	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
329726002049	GTPase/Zn-binding domain interface [polypeptide binding]; other site
329726002050	GTP/Mg2+ binding site [chemical binding]; other site
329726002051	G4 box; other site
329726002052	G5 box; other site
329726002053	G1 box; other site
329726002054	Switch I region; other site
329726002055	G2 box; other site
329726002056	G3 box; other site
329726002057	Switch II region; other site
329726002058	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
329726002059	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
329726002060	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
329726002061	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
329726002062	substrate binding site [chemical binding]; other site
329726002063	Late competence development protein ComFB; Region: ComFB; pfam10719
329726002064	Response regulator receiver domain; Region: Response_reg; pfam00072
329726002065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726002066	active site
329726002067	phosphorylation site [posttranslational modification]
329726002068	intermolecular recognition site; other site
329726002069	dimerization interface [polypeptide binding]; other site
329726002070	Response regulator receiver domain; Region: Response_reg; pfam00072
329726002071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726002072	active site
329726002073	phosphorylation site [posttranslational modification]
329726002074	intermolecular recognition site; other site
329726002075	dimerization interface [polypeptide binding]; other site
329726002076	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
329726002077	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726002078	dimerization interface [polypeptide binding]; other site
329726002079	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
329726002080	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
329726002081	dimer interface [polypeptide binding]; other site
329726002082	putative CheW interface [polypeptide binding]; other site
329726002083	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
329726002084	putative binding surface; other site
329726002085	active site
329726002086	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
329726002087	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
329726002088	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726002089	ATP binding site [chemical binding]; other site
329726002090	Mg2+ binding site [ion binding]; other site
329726002091	G-X-G motif; other site
329726002092	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
329726002093	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726002094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726002095	active site
329726002096	phosphorylation site [posttranslational modification]
329726002097	intermolecular recognition site; other site
329726002098	dimerization interface [polypeptide binding]; other site
329726002099	CheW-like domain; Region: CheW; pfam01584
329726002100	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
329726002101	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
329726002102	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
329726002103	MoaE interaction surface [polypeptide binding]; other site
329726002104	MoeB interaction surface [polypeptide binding]; other site
329726002105	thiocarboxylated glycine; other site
329726002106	threonine synthase; Validated; Region: PRK07591
329726002107	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
329726002108	homodimer interface [polypeptide binding]; other site
329726002109	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726002110	catalytic residue [active]
329726002111	Lamin Tail Domain; Region: LTD; pfam00932
329726002112	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
329726002113	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
329726002114	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
329726002115	SmpB-tmRNA interface; other site
329726002116	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
329726002117	ribosome maturation protein RimP; Reviewed; Region: PRK00092
329726002118	Sm and related proteins; Region: Sm_like; cl00259
329726002119	heptamer interface [polypeptide binding]; other site
329726002120	Sm1 motif; other site
329726002121	hexamer interface [polypeptide binding]; other site
329726002122	RNA binding site [nucleotide binding]; other site
329726002123	Sm2 motif; other site
329726002124	transcription elongation factor NusA; Provisional; Region: nusA; PRK12329
329726002125	NusA N-terminal domain; Region: NusA_N; pfam08529
329726002126	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
329726002127	RNA binding site [nucleotide binding]; other site
329726002128	homodimer interface [polypeptide binding]; other site
329726002129	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
329726002130	G-X-X-G motif; other site
329726002131	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
329726002132	G-X-X-G motif; other site
329726002133	translation initiation factor IF-2; Region: IF-2; TIGR00487
329726002134	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
329726002135	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
329726002136	G1 box; other site
329726002137	putative GEF interaction site [polypeptide binding]; other site
329726002138	GTP/Mg2+ binding site [chemical binding]; other site
329726002139	Switch I region; other site
329726002140	G2 box; other site
329726002141	G3 box; other site
329726002142	Switch II region; other site
329726002143	G4 box; other site
329726002144	G5 box; other site
329726002145	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
329726002146	Translation-initiation factor 2; Region: IF-2; pfam11987
329726002147	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
329726002148	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
329726002149	active site
329726002150	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
329726002151	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
329726002152	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
329726002153	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
329726002154	trimer interface [polypeptide binding]; other site
329726002155	active site
329726002156	substrate binding site [chemical binding]; other site
329726002157	CoA binding site [chemical binding]; other site
329726002158	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
329726002159	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
329726002160	Probable Catalytic site; other site
329726002161	metal-binding site
329726002162	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
329726002163	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
329726002164	GatB domain; Region: GatB_Yqey; smart00845
329726002165	Phosphopantetheine attachment site; Region: PP-binding; cl09936
329726002166	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
329726002167	nucleoside/Zn binding site; other site
329726002168	dimer interface [polypeptide binding]; other site
329726002169	catalytic motif [active]
329726002170	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
329726002171	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
329726002172	hinge; other site
329726002173	active site
329726002174	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
329726002175	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726002176	dimer interface [polypeptide binding]; other site
329726002177	conserved gate region; other site
329726002178	ABC-ATPase subunit interface; other site
329726002179	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
329726002180	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
329726002181	Cl- selectivity filter; other site
329726002182	Cl- binding residues [ion binding]; other site
329726002183	pore gating glutamate residue; other site
329726002184	dimer interface [polypeptide binding]; other site
329726002185	H+/Cl- coupling transport residue; other site
329726002186	FOG: CBS domain [General function prediction only]; Region: COG0517
329726002187	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
329726002188	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
329726002189	Ligand Binding Site [chemical binding]; other site
329726002190	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726002191	Ligand Binding Site [chemical binding]; other site
329726002192	cytochrome c-550; Provisional; Region: psbV; cl17239
329726002193	Dihaem cytochrome c; Region: DHC; pfam09626
329726002194	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
329726002195	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
329726002196	C-terminal domain interface [polypeptide binding]; other site
329726002197	GSH binding site (G-site) [chemical binding]; other site
329726002198	dimer interface [polypeptide binding]; other site
329726002199	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
329726002200	N-terminal domain interface [polypeptide binding]; other site
329726002201	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
329726002202	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
329726002203	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
329726002204	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
329726002205	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
329726002206	domain interfaces; other site
329726002207	active site
329726002208	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
329726002209	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
329726002210	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
329726002211	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
329726002212	Soluble P-type ATPase [General function prediction only]; Region: COG4087
329726002213	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
329726002214	HEAT repeats; Region: HEAT_2; pfam13646
329726002215	HEAT repeats; Region: HEAT_2; pfam13646
329726002216	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
329726002217	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726002218	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726002219	ligand binding site [chemical binding]; other site
329726002220	flexible hinge region; other site
329726002221	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726002222	putative active site [active]
329726002223	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
329726002224	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
329726002225	metal-binding site [ion binding]
329726002226	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
329726002227	Soluble P-type ATPase [General function prediction only]; Region: COG4087
329726002228	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
329726002229	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
329726002230	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
329726002231	Surface antigen; Region: Bac_surface_Ag; pfam01103
329726002232	GAF domain; Region: GAF; cl17456
329726002233	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726002234	dimer interface [polypeptide binding]; other site
329726002235	phosphorylation site [posttranslational modification]
329726002236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726002237	ATP binding site [chemical binding]; other site
329726002238	Mg2+ binding site [ion binding]; other site
329726002239	G-X-G motif; other site
329726002240	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
329726002241	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
329726002242	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
329726002243	catalytic residue [active]
329726002244	putative FPP diphosphate  binding site; other site
329726002245	putative FPP binding hydrophobic cleft; other site
329726002246	dimer interface [polypeptide binding]; other site
329726002247	putative IPP diphosphate binding site; other site
329726002248	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
329726002249	dinuclear metal binding motif [ion binding]; other site
329726002250	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726002251	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726002252	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726002253	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726002254	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
329726002255	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726002256	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726002257	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726002258	TPR repeat; Region: TPR_11; pfam13414
329726002259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726002260	binding surface
329726002261	TPR motif; other site
329726002262	TPR repeat; Region: TPR_11; pfam13414
329726002263	TPR repeat; Region: TPR_11; pfam13414
329726002264	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726002265	binding surface
329726002266	TPR motif; other site
329726002267	TPR repeat; Region: TPR_11; pfam13414
329726002268	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726002269	binding surface
329726002270	TPR motif; other site
329726002271	hypothetical protein; Provisional; Region: PRK07236
329726002272	FAD binding domain; Region: FAD_binding_3; pfam01494
329726002273	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
329726002274	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
329726002275	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
329726002276	Walker A/P-loop; other site
329726002277	ATP binding site [chemical binding]; other site
329726002278	Q-loop/lid; other site
329726002279	ABC transporter signature motif; other site
329726002280	Walker B; other site
329726002281	D-loop; other site
329726002282	H-loop/switch region; other site
329726002283	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
329726002284	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
329726002285	DevC protein; Region: devC; TIGR01185
329726002286	FtsX-like permease family; Region: FtsX; pfam02687
329726002287	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
329726002288	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726002289	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726002290	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726002291	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
329726002292	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
329726002293	active site
329726002294	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
329726002295	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
329726002296	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
329726002297	Walker A/P-loop; other site
329726002298	ATP binding site [chemical binding]; other site
329726002299	Q-loop/lid; other site
329726002300	ABC transporter signature motif; other site
329726002301	Walker B; other site
329726002302	D-loop; other site
329726002303	H-loop/switch region; other site
329726002304	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
329726002305	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
329726002306	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726002307	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726002308	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726002309	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
329726002310	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
329726002311	putative metal binding site; other site
329726002312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726002313	binding surface
329726002314	TPR motif; other site
329726002315	TPR repeat; Region: TPR_11; pfam13414
329726002316	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
329726002317	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
329726002318	Walker A motif; other site
329726002319	ATP binding site [chemical binding]; other site
329726002320	Walker B motif; other site
329726002321	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
329726002322	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
329726002323	Walker A motif; other site
329726002324	Walker A motif; other site
329726002325	ATP binding site [chemical binding]; other site
329726002326	Walker B motif; other site
329726002327	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
329726002328	tetramer interface [polypeptide binding]; other site
329726002329	dimer interface [polypeptide binding]; other site
329726002330	KaiA domain; Region: KaiA; pfam07688
329726002331	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
329726002332	catalytic triad [active]
329726002333	glycogen branching enzyme; Provisional; Region: PRK05402
329726002334	Carbohydrate-binding module 48 (Isoamylase N-terminal domain); Region: CBM_48; pfam02922
329726002335	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
329726002336	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
329726002337	active site
329726002338	catalytic site [active]
329726002339	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
329726002340	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726002341	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726002342	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726002343	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
329726002344	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
329726002345	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
329726002346	trimer interface [polypeptide binding]; other site
329726002347	active site
329726002348	substrate binding site [chemical binding]; other site
329726002349	CoA binding site [chemical binding]; other site
329726002350	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
329726002351	nucleoside/Zn binding site; other site
329726002352	dimer interface [polypeptide binding]; other site
329726002353	catalytic motif [active]
329726002354	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
329726002355	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
329726002356	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
329726002357	NAD(P) binding site [chemical binding]; other site
329726002358	catalytic residues [active]
329726002359	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
329726002360	homopentamer interface [polypeptide binding]; other site
329726002361	active site
329726002362	YCF9; Region: Ycf9; cl09269
329726002363	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
329726002364	DHH family; Region: DHH; pfam01368
329726002365	FOG: CBS domain [General function prediction only]; Region: COG0517
329726002366	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
329726002367	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
329726002368	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
329726002369	active site
329726002370	NTP binding site [chemical binding]; other site
329726002371	metal binding triad [ion binding]; metal-binding site
329726002372	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
329726002373	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
329726002374	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726002375	dimer interface [polypeptide binding]; other site
329726002376	ABC-ATPase subunit interface; other site
329726002377	putative PBP binding loops; other site
329726002378	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
329726002379	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726002380	dimer interface [polypeptide binding]; other site
329726002381	conserved gate region; other site
329726002382	putative PBP binding loops; other site
329726002383	ABC-ATPase subunit interface; other site
329726002384	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
329726002385	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
329726002386	Walker A/P-loop; other site
329726002387	ATP binding site [chemical binding]; other site
329726002388	Q-loop/lid; other site
329726002389	ABC transporter signature motif; other site
329726002390	Walker B; other site
329726002391	D-loop; other site
329726002392	H-loop/switch region; other site
329726002393	Domain of unknown function DUF11; Region: DUF11; pfam01345
329726002394	Domain of unknown function DUF11; Region: DUF11; pfam01345
329726002395	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
329726002396	UbiA prenyltransferase family; Region: UbiA; pfam01040
329726002397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726002398	S-adenosylmethionine binding site [chemical binding]; other site
329726002399	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
329726002400	active site
329726002401	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726002402	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
329726002403	putative ADP-binding pocket [chemical binding]; other site
329726002404	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726002405	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726002406	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
329726002407	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
329726002408	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
329726002409	Ligand binding site; other site
329726002410	Putative Catalytic site; other site
329726002411	DXD motif; other site
329726002412	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
329726002413	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726002414	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726002415	S-adenosylmethionine binding site [chemical binding]; other site
329726002416	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726002417	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
329726002418	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
329726002419	HIGH motif; other site
329726002420	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
329726002421	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
329726002422	active site
329726002423	KMSKS motif; other site
329726002424	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
329726002425	tRNA binding surface [nucleotide binding]; other site
329726002426	RNase_H superfamily; Region: RNase_H_2; pfam13482
329726002427	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
329726002428	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
329726002429	Predicted transcriptional regulator [Transcription]; Region: COG3636
329726002430	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726002431	putative active site [active]
329726002432	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
329726002433	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
329726002434	putative active site [active]
329726002435	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
329726002436	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
329726002437	conserved cys residue [active]
329726002438	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726002439	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726002440	Coenzyme A binding pocket [chemical binding]; other site
329726002441	Homeodomain-like domain; Region: HTH_23; pfam13384
329726002442	Winged helix-turn helix; Region: HTH_29; pfam13551
329726002443	Winged helix-turn helix; Region: HTH_33; pfam13592
329726002444	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726002445	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
329726002446	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726002447	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
329726002448	dimerization interface [polypeptide binding]; other site
329726002449	substrate binding pocket [chemical binding]; other site
329726002450	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
329726002451	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726002452	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726002453	structural tetrad; other site
329726002454	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726002455	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726002456	structural tetrad; other site
329726002457	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
329726002458	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726002459	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726002460	metal binding site [ion binding]; metal-binding site
329726002461	active site
329726002462	I-site; other site
329726002463	YHYH protein; Region: YHYH; pfam14240
329726002464	Maf-like protein; Region: Maf; pfam02545
329726002465	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
329726002466	active site
329726002467	dimer interface [polypeptide binding]; other site
329726002468	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
329726002469	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
329726002470	Clostripain family; Region: Peptidase_C11; pfam03415
329726002471	methionine aminopeptidase; Provisional; Region: PRK12318
329726002472	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
329726002473	active site
329726002474	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
329726002475	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726002476	Bacitracin resistance protein BacA; Region: BacA; pfam02673
329726002477	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
329726002478	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726002479	Coenzyme A binding pocket [chemical binding]; other site
329726002480	quinolinate synthetase; Provisional; Region: PRK09375
329726002481	Protein of unknown function (DUF552); Region: DUF552; pfam04472
329726002482	FAD binding domain; Region: FAD_binding_4; pfam01565
329726002483	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
329726002484	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
329726002485	Uncharacterized conserved protein [Function unknown]; Region: COG2013
329726002486	Major royal jelly protein; Region: MRJP; pfam03022
329726002487	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
329726002488	Fatty acid desaturase; Region: FA_desaturase; pfam00487
329726002489	putative di-iron ligands [ion binding]; other site
329726002490	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
329726002491	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
329726002492	putative GSH binding site (G-site) [chemical binding]; other site
329726002493	active site cysteine [active]
329726002494	putative C-terminal domain interface [polypeptide binding]; other site
329726002495	putative dimer interface [polypeptide binding]; other site
329726002496	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
329726002497	putative N-terminal domain interface [polypeptide binding]; other site
329726002498	putative dimer interface [polypeptide binding]; other site
329726002499	putative substrate binding pocket (H-site) [chemical binding]; other site
329726002500	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
329726002501	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
329726002502	active site residue [active]
329726002503	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
329726002504	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
329726002505	dimer interface [polypeptide binding]; other site
329726002506	active site
329726002507	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726002508	Coenzyme A binding pocket [chemical binding]; other site
329726002509	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
329726002510	active site
329726002511	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
329726002512	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
329726002513	D1 interface; other site
329726002514	chlorophyll binding site; other site
329726002515	pheophytin binding site; other site
329726002516	beta carotene binding site; other site
329726002517	cytochrome b559 beta interface; other site
329726002518	quinone binding site; other site
329726002519	cytochrome b559 alpha interface; other site
329726002520	protein J interface; other site
329726002521	protein H interface; other site
329726002522	protein X interface; other site
329726002523	core light harvesting protein interface; other site
329726002524	protein L interface; other site
329726002525	CP43 interface; other site
329726002526	protein T interface; other site
329726002527	Fe binding site [ion binding]; other site
329726002528	protein M interface; other site
329726002529	Mn-stabilizing polypeptide interface; other site
329726002530	bromide binding site; other site
329726002531	cytochrome c-550 interface; other site
329726002532	Photosystem II protein; Region: PSII; cl08223
329726002533	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
329726002534	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
329726002535	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
329726002536	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
329726002537	ATP binding site [chemical binding]; other site
329726002538	putative Mg++ binding site [ion binding]; other site
329726002539	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
329726002540	GAF domain; Region: GAF; pfam01590
329726002541	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726002542	GAF domain; Region: GAF; pfam01590
329726002543	GAF domain; Region: GAF; pfam01590
329726002544	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
329726002545	Mg2+ binding site [ion binding]; other site
329726002546	G-X-G motif; other site
329726002547	MarC family integral membrane protein; Region: MarC; cl00919
329726002548	ATP-grasp domain; Region: ATP-grasp_4; cl17255
329726002549	ATP-grasp domain; Region: ATP-grasp_4; cl17255
329726002550	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
329726002551	catalytic nucleophile [active]
329726002552	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726002553	haemagglutination activity domain; Region: Haemagg_act; pfam05860
329726002554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726002555	S-adenosylmethionine binding site [chemical binding]; other site
329726002556	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
329726002557	heterotetramer interface [polypeptide binding]; other site
329726002558	active site pocket [active]
329726002559	cleavage site
329726002560	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
329726002561	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726002562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726002563	active site
329726002564	phosphorylation site [posttranslational modification]
329726002565	intermolecular recognition site; other site
329726002566	dimerization interface [polypeptide binding]; other site
329726002567	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
329726002568	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
329726002569	putative binding surface; other site
329726002570	active site
329726002571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726002572	ATP binding site [chemical binding]; other site
329726002573	Mg2+ binding site [ion binding]; other site
329726002574	G-X-G motif; other site
329726002575	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
329726002576	Response regulator receiver domain; Region: Response_reg; pfam00072
329726002577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726002578	active site
329726002579	phosphorylation site [posttranslational modification]
329726002580	intermolecular recognition site; other site
329726002581	dimerization interface [polypeptide binding]; other site
329726002582	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
329726002583	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
329726002584	dimer interface [polypeptide binding]; other site
329726002585	putative CheW interface [polypeptide binding]; other site
329726002586	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
329726002587	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
329726002588	dimer interface [polypeptide binding]; other site
329726002589	putative CheW interface [polypeptide binding]; other site
329726002590	CheW-like domain; Region: CheW; pfam01584
329726002591	Response regulator receiver domain; Region: Response_reg; pfam00072
329726002592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726002593	active site
329726002594	phosphorylation site [posttranslational modification]
329726002595	intermolecular recognition site; other site
329726002596	dimerization interface [polypeptide binding]; other site
329726002597	GatB domain; Region: GatB_Yqey; cl17694
329726002598	Response regulator receiver domain; Region: Response_reg; pfam00072
329726002599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726002600	active site
329726002601	phosphorylation site [posttranslational modification]
329726002602	intermolecular recognition site; other site
329726002603	dimerization interface [polypeptide binding]; other site
329726002604	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
329726002605	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
329726002606	dimer interface [polypeptide binding]; other site
329726002607	tetramer interface [polypeptide binding]; other site
329726002608	PYR/PP interface [polypeptide binding]; other site
329726002609	TPP binding site [chemical binding]; other site
329726002610	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
329726002611	TPP-binding site; other site
329726002612	salicylate synthase; Region: salicyl_syn; TIGR03494
329726002613	chorismate binding enzyme; Region: Chorismate_bind; cl10555
329726002614	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
329726002615	UbiA prenyltransferase family; Region: UbiA; pfam01040
329726002616	chaperone protein DnaJ; Provisional; Region: PRK14299
329726002617	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
329726002618	HSP70 interaction site [polypeptide binding]; other site
329726002619	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
329726002620	substrate binding site [polypeptide binding]; other site
329726002621	dimer interface [polypeptide binding]; other site
329726002622	Ycf39; Provisional; Region: ycf39; CHL00194
329726002623	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
329726002624	NAD(P) binding site [chemical binding]; other site
329726002625	putative active site [active]
329726002626	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
329726002627	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
329726002628	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
329726002629	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
329726002630	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
329726002631	GIY-YIG motif/motif A; other site
329726002632	active site
329726002633	catalytic site [active]
329726002634	putative DNA binding site [nucleotide binding]; other site
329726002635	metal binding site [ion binding]; metal-binding site
329726002636	UvrB/uvrC motif; Region: UVR; pfam02151
329726002637	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
329726002638	Helix-hairpin-helix motif; Region: HHH; pfam00633
329726002639	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
329726002640	glycogen synthase; Provisional; Region: glgA; PRK00654
329726002641	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
329726002642	ADP-binding pocket [chemical binding]; other site
329726002643	homodimer interface [polypeptide binding]; other site
329726002644	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
329726002645	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726002646	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726002647	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
329726002648	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726002649	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726002650	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726002651	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
329726002652	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834
329726002653	Photosystem II protein Y (PsbY); Region: PsbY; cl05675
329726002654	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
329726002655	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834
329726002656	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
329726002657	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726002658	metal binding site 2 [ion binding]; metal-binding site
329726002659	putative DNA binding helix; other site
329726002660	metal binding site 1 [ion binding]; metal-binding site
329726002661	dimer interface [polypeptide binding]; other site
329726002662	structural Zn2+ binding site [ion binding]; other site
329726002663	Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869
329726002664	dimer interface [polypeptide binding]; other site
329726002665	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726002666	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726002667	binding surface
329726002668	TPR motif; other site
329726002669	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
329726002670	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
329726002671	catalytic core [active]
329726002672	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
329726002673	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
329726002674	Tetramer interface [polypeptide binding]; other site
329726002675	active site
329726002676	FMN-binding site [chemical binding]; other site
329726002677	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
329726002678	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
329726002679	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
329726002680	active site residue [active]
329726002681	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
329726002682	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
329726002683	putative active site [active]
329726002684	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
329726002685	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726002686	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726002687	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
329726002688	IHF dimer interface [polypeptide binding]; other site
329726002689	IHF - DNA interface [nucleotide binding]; other site
329726002690	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
329726002691	phosphatidate cytidylyltransferase; Region: PLN02953
329726002692	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
329726002693	anti sigma factor interaction site; other site
329726002694	regulatory phosphorylation site [posttranslational modification]; other site
329726002695	Response regulator receiver domain; Region: Response_reg; pfam00072
329726002696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726002697	active site
329726002698	phosphorylation site [posttranslational modification]
329726002699	intermolecular recognition site; other site
329726002700	dimerization interface [polypeptide binding]; other site
329726002701	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
329726002702	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
329726002703	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
329726002704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
329726002705	Mg2+ binding site [ion binding]; other site
329726002706	Type III pantothenate kinase; Region: Pan_kinase; cl17198
329726002707	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
329726002708	nudix motif; other site
329726002709	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
329726002710	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
329726002711	catalytic triad [active]
329726002712	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726002713	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726002714	Coenzyme A binding pocket [chemical binding]; other site
329726002715	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
329726002716	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726002717	ATP binding site [chemical binding]; other site
329726002718	putative Mg++ binding site [ion binding]; other site
329726002719	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726002720	nucleotide binding region [chemical binding]; other site
329726002721	ATP-binding site [chemical binding]; other site
329726002722	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726002723	Major Facilitator Superfamily; Region: MFS_1; pfam07690
329726002724	putative substrate translocation pore; other site
329726002725	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
329726002726	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
329726002727	Na binding site [ion binding]; other site
329726002728	putative glycosylation site [posttranslational modification]; other site
329726002729	putative glycosylation site [posttranslational modification]; other site
329726002730	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726002731	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
329726002732	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
329726002733	catalytic residues [active]
329726002734	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
329726002735	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
329726002736	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
329726002737	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726002738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726002739	S-adenosylmethionine binding site [chemical binding]; other site
329726002740	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
329726002741	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
329726002742	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
329726002743	C-terminal domain interface [polypeptide binding]; other site
329726002744	GSH binding site (G-site) [chemical binding]; other site
329726002745	dimer interface [polypeptide binding]; other site
329726002746	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
329726002747	N-terminal domain interface [polypeptide binding]; other site
329726002748	putative dimer interface [polypeptide binding]; other site
329726002749	active site
329726002750	Protein kinase domain; Region: Pkinase; pfam00069
329726002751	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726002752	active site
329726002753	ATP binding site [chemical binding]; other site
329726002754	substrate binding site [chemical binding]; other site
329726002755	activation loop (A-loop); other site
329726002756	AAA ATPase domain; Region: AAA_16; pfam13191
329726002757	Predicted ATPase [General function prediction only]; Region: COG3899
329726002758	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726002759	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726002760	PAS domain S-box; Region: sensory_box; TIGR00229
329726002761	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726002762	putative active site [active]
329726002763	heme pocket [chemical binding]; other site
329726002764	PAS domain S-box; Region: sensory_box; TIGR00229
329726002765	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726002766	putative active site [active]
329726002767	heme pocket [chemical binding]; other site
329726002768	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726002769	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726002770	putative active site [active]
329726002771	heme pocket [chemical binding]; other site
329726002772	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726002773	putative active site [active]
329726002774	heme pocket [chemical binding]; other site
329726002775	PAS domain S-box; Region: sensory_box; TIGR00229
329726002776	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726002777	putative active site [active]
329726002778	heme pocket [chemical binding]; other site
329726002779	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
329726002780	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726002781	putative active site [active]
329726002782	heme pocket [chemical binding]; other site
329726002783	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726002784	dimer interface [polypeptide binding]; other site
329726002785	phosphorylation site [posttranslational modification]
329726002786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726002787	ATP binding site [chemical binding]; other site
329726002788	Mg2+ binding site [ion binding]; other site
329726002789	G-X-G motif; other site
329726002790	Response regulator receiver domain; Region: Response_reg; pfam00072
329726002791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726002792	active site
329726002793	phosphorylation site [posttranslational modification]
329726002794	intermolecular recognition site; other site
329726002795	dimerization interface [polypeptide binding]; other site
329726002796	Protein kinase domain; Region: Pkinase; pfam00069
329726002797	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726002798	active site
329726002799	ATP binding site [chemical binding]; other site
329726002800	substrate binding site [chemical binding]; other site
329726002801	activation loop (A-loop); other site
329726002802	Predicted ATPase [General function prediction only]; Region: COG3899
329726002803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726002804	Walker A motif; other site
329726002805	ATP binding site [chemical binding]; other site
329726002806	Walker B motif; other site
329726002807	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726002808	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726002809	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726002810	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726002811	putative active site [active]
329726002812	heme pocket [chemical binding]; other site
329726002813	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726002814	putative active site [active]
329726002815	heme pocket [chemical binding]; other site
329726002816	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726002817	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726002818	putative active site [active]
329726002819	heme pocket [chemical binding]; other site
329726002820	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726002821	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726002822	putative active site [active]
329726002823	heme pocket [chemical binding]; other site
329726002824	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726002825	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726002826	putative active site [active]
329726002827	heme pocket [chemical binding]; other site
329726002828	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726002829	putative active site [active]
329726002830	heme pocket [chemical binding]; other site
329726002831	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
329726002832	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726002833	GAF domain; Region: GAF; pfam01590
329726002834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726002835	dimer interface [polypeptide binding]; other site
329726002836	phosphorylation site [posttranslational modification]
329726002837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726002838	ATP binding site [chemical binding]; other site
329726002839	Mg2+ binding site [ion binding]; other site
329726002840	G-X-G motif; other site
329726002841	Response regulator receiver domain; Region: Response_reg; pfam00072
329726002842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726002843	active site
329726002844	phosphorylation site [posttranslational modification]
329726002845	intermolecular recognition site; other site
329726002846	dimerization interface [polypeptide binding]; other site
329726002847	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
329726002848	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
329726002849	nucleotide binding pocket [chemical binding]; other site
329726002850	K-X-D-G motif; other site
329726002851	catalytic site [active]
329726002852	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
329726002853	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
329726002854	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
329726002855	Dimer interface [polypeptide binding]; other site
329726002856	BRCT sequence motif; other site
329726002857	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
329726002858	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
329726002859	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
329726002860	putative NAD(P) binding site [chemical binding]; other site
329726002861	active site
329726002862	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
329726002863	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
329726002864	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
329726002865	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
329726002866	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
329726002867	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
329726002868	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
329726002869	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
329726002870	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
329726002871	P-loop, Walker A motif; other site
329726002872	Base recognition motif; other site
329726002873	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
329726002874	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726002875	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726002876	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
329726002877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726002878	S-adenosylmethionine binding site [chemical binding]; other site
329726002879	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726002880	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726002881	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726002882	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726002883	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726002884	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726002885	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726002886	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
329726002887	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
329726002888	active site
329726002889	Homeodomain-like domain; Region: HTH_23; pfam13384
329726002890	Winged helix-turn helix; Region: HTH_29; pfam13551
329726002891	Winged helix-turn helix; Region: HTH_33; pfam13592
329726002892	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726002893	Restriction endonuclease; Region: Mrr_cat; pfam04471
329726002894	NACHT domain; Region: NACHT; pfam05729
329726002895	PQQ-like domain; Region: PQQ_2; pfam13360
329726002896	WD40 repeats; Region: WD40; smart00320
329726002897	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726002898	structural tetrad; other site
329726002899	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
329726002900	RNA polymerase sigma factor; Provisional; Region: PRK12519
329726002901	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726002902	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726002903	DNA binding residues [nucleotide binding]
329726002904	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
329726002905	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
329726002906	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
329726002907	Predicted membrane protein [Function unknown]; Region: COG2259
329726002908	ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365
329726002909	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726002910	Radical SAM superfamily; Region: Radical_SAM; pfam04055
329726002911	FeS/SAM binding site; other site
329726002912	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
329726002913	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
329726002914	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
329726002915	catalytic residue [active]
329726002916	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
329726002917	FeS assembly protein SufD; Region: sufD; TIGR01981
329726002918	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
329726002919	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
329726002920	Walker A/P-loop; other site
329726002921	ATP binding site [chemical binding]; other site
329726002922	Q-loop/lid; other site
329726002923	ABC transporter signature motif; other site
329726002924	Walker B; other site
329726002925	D-loop; other site
329726002926	H-loop/switch region; other site
329726002927	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
329726002928	putative ABC transporter; Region: ycf24; CHL00085
329726002929	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
329726002930	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
329726002931	putative DNA binding site [nucleotide binding]; other site
329726002932	putative Zn2+ binding site [ion binding]; other site
329726002933	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726002934	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726002935	S-adenosylmethionine binding site [chemical binding]; other site
329726002936	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726002937	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726002938	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
329726002939	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
329726002940	C-terminal domain interface [polypeptide binding]; other site
329726002941	GSH binding site (G-site) [chemical binding]; other site
329726002942	dimer interface [polypeptide binding]; other site
329726002943	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
329726002944	N-terminal domain interface [polypeptide binding]; other site
329726002945	dimer interface [polypeptide binding]; other site
329726002946	substrate binding pocket (H-site) [chemical binding]; other site
329726002947	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
329726002948	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
329726002949	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
329726002950	putative dimer interface [polypeptide binding]; other site
329726002951	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726002952	ligand binding site [chemical binding]; other site
329726002953	Zn binding site [ion binding]; other site
329726002954	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
329726002955	6-phosphofructokinase; Region: PLN02884
329726002956	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
329726002957	TIGR03032 family protein; Region: TIGR03032
329726002958	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
329726002959	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726002960	binding surface
329726002961	TPR motif; other site
329726002962	TPR repeat; Region: TPR_11; pfam13414
329726002963	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726002964	binding surface
329726002965	TPR motif; other site
329726002966	TPR repeat; Region: TPR_11; pfam13414
329726002967	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726002968	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726002969	Family description; Region: VCBS; pfam13517
329726002970	Family description; Region: VCBS; pfam13517
329726002971	Family description; Region: VCBS; pfam13517
329726002972	Family description; Region: VCBS; pfam13517
329726002973	Family description; Region: VCBS; pfam13517
329726002974	Calx-beta domain; Region: Calx-beta; cl02522
329726002975	Family description; Region: VCBS; pfam13517
329726002976	Family description; Region: VCBS; pfam13517
329726002977	Family description; Region: VCBS; pfam13517
329726002978	Family description; Region: VCBS; pfam13517
329726002979	Family description; Region: VCBS; pfam13517
329726002980	Calx-beta domain; Region: Calx-beta; cl02522
329726002981	Family description; Region: VCBS; pfam13517
329726002982	Family description; Region: VCBS; pfam13517
329726002983	Family description; Region: VCBS; pfam13517
329726002984	Family description; Region: VCBS; pfam13517
329726002985	Family description; Region: VCBS; pfam13517
329726002986	Family description; Region: VCBS; pfam13517
329726002987	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726002988	Homeodomain-like domain; Region: HTH_23; pfam13384
329726002989	Winged helix-turn helix; Region: HTH_29; pfam13551
329726002990	Homeodomain-like domain; Region: HTH_32; pfam13565
329726002991	Family description; Region: VCBS; pfam13517
329726002992	Family description; Region: VCBS; pfam13517
329726002993	Family description; Region: VCBS; pfam13517
329726002994	Family description; Region: VCBS; pfam13517
329726002995	Family description; Region: VCBS; pfam13517
329726002996	acyl-CoA synthetase; Provisional; Region: PRK13382
329726002997	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
329726002998	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
329726002999	active site
329726003000	CoA binding site [chemical binding]; other site
329726003001	AMP binding site [chemical binding]; other site
329726003002	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726003003	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
329726003004	NAD(P) binding site [chemical binding]; other site
329726003005	active site
329726003006	threonine synthase; Validated; Region: PRK06260
329726003007	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
329726003008	homodimer interface [polypeptide binding]; other site
329726003009	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726003010	catalytic residue [active]
329726003011	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
329726003012	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
329726003013	peptide chain release factor 1; Validated; Region: prfA; PRK00591
329726003014	This domain is found in peptide chain release factors; Region: PCRF; smart00937
329726003015	RF-1 domain; Region: RF-1; pfam00472
329726003016	ribosomal protein L31; Validated; Region: rpl31; CHL00136
329726003017	ribosomal protein S9; Region: rps9; CHL00079
329726003018	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
329726003019	23S rRNA interface [nucleotide binding]; other site
329726003020	L3 interface [polypeptide binding]; other site
329726003021	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
329726003022	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
329726003023	dimerization interface 3.5A [polypeptide binding]; other site
329726003024	active site
329726003025	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
329726003026	RNA polymerase alpha subunit; Region: rpoA; CHL00013
329726003027	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
329726003028	alphaNTD homodimer interface [polypeptide binding]; other site
329726003029	alphaNTD - beta interaction site [polypeptide binding]; other site
329726003030	alphaNTD - beta' interaction site [polypeptide binding]; other site
329726003031	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
329726003032	30S ribosomal protein S11; Validated; Region: PRK05309
329726003033	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
329726003034	30S ribosomal protein S13; Region: bact_S13; TIGR03631
329726003035	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
329726003036	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
329726003037	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
329726003038	substrate binding pocket [chemical binding]; other site
329726003039	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
329726003040	B12 binding site [chemical binding]; other site
329726003041	cobalt ligand [ion binding]; other site
329726003042	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
329726003043	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726003044	putative active site [active]
329726003045	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726003046	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726003047	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726003048	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726003049	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
329726003050	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
329726003051	putative active site [active]
329726003052	catalytic site [active]
329726003053	putative metal binding site [ion binding]; other site
329726003054	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726003055	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726003056	putative active site [active]
329726003057	heme pocket [chemical binding]; other site
329726003058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726003059	putative active site [active]
329726003060	heme pocket [chemical binding]; other site
329726003061	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726003062	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726003063	metal binding site [ion binding]; metal-binding site
329726003064	active site
329726003065	I-site; other site
329726003066	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726003067	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
329726003068	Dynamin family; Region: Dynamin_N; pfam00350
329726003069	G1 box; other site
329726003070	GTP/Mg2+ binding site [chemical binding]; other site
329726003071	G2 box; other site
329726003072	Switch I region; other site
329726003073	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
329726003074	G3 box; other site
329726003075	Switch II region; other site
329726003076	GTP/Mg2+ binding site [chemical binding]; other site
329726003077	G4 box; other site
329726003078	G5 box; other site
329726003079	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
329726003080	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
329726003081	catalytic residue [active]
329726003082	hypothetical protein; Provisional; Region: PRK09256
329726003083	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
329726003084	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
329726003085	GIY-YIG motif/motif A; other site
329726003086	putative active site [active]
329726003087	putative metal binding site [ion binding]; other site
329726003088	hypothetical protein; Provisional; Region: PRK01617
329726003089	SEC-C motif; Region: SEC-C; pfam02810
329726003090	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
329726003091	Uncharacterized conserved protein [Function unknown]; Region: COG1479
329726003092	Protein of unknown function DUF262; Region: DUF262; pfam03235
329726003093	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
329726003094	Predicted transcriptional regulators [Transcription]; Region: COG1695
329726003095	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
329726003096	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
329726003097	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
329726003098	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
329726003099	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
329726003100	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
329726003101	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
329726003102	ligand binding site [chemical binding]; other site
329726003103	NAD binding site [chemical binding]; other site
329726003104	dimerization interface [polypeptide binding]; other site
329726003105	catalytic site [active]
329726003106	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
329726003107	putative L-serine binding site [chemical binding]; other site
329726003108	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
329726003109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726003110	S-adenosylmethionine binding site [chemical binding]; other site
329726003111	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
329726003112	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
329726003113	nucleotide binding site/active site [active]
329726003114	HIT family signature motif; other site
329726003115	catalytic residue [active]
329726003116	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
329726003117	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
329726003118	conserved hypothetical protein; Region: TIGR03492
329726003119	S-layer homology domain; Region: SLH; pfam00395
329726003120	S-layer homology domain; Region: SLH; pfam00395
329726003121	S-layer homology domain; Region: SLH; pfam00395
329726003122	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
329726003123	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726003124	FeS/SAM binding site; other site
329726003125	HemN C-terminal domain; Region: HemN_C; pfam06969
329726003126	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
329726003127	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
329726003128	putative active site [active]
329726003129	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
329726003130	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
329726003131	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726003132	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
329726003133	active site
329726003134	catalytic residues [active]
329726003135	DNA binding site [nucleotide binding]
329726003136	Int/Topo IB signature motif; other site
329726003137	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
329726003138	active site
329726003139	metal binding site [ion binding]; metal-binding site
329726003140	interdomain interaction site; other site
329726003141	AAA domain; Region: AAA_25; pfam13481
329726003142	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
329726003143	Walker A motif; other site
329726003144	ATP binding site [chemical binding]; other site
329726003145	Walker B motif; other site
329726003146	Predicted transcriptional regulator [Transcription]; Region: COG2932
329726003147	Helix-turn-helix; Region: HTH_3; pfam01381
329726003148	sequence-specific DNA binding site [nucleotide binding]; other site
329726003149	salt bridge; other site
329726003150	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
329726003151	Catalytic site [active]
329726003152	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
329726003153	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
329726003154	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
329726003155	Walker A motif; other site
329726003156	ATP binding site [chemical binding]; other site
329726003157	Walker B motif; other site
329726003158	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
329726003159	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
329726003160	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726003161	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
329726003162	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726003163	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726003164	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726003165	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
329726003166	DNA binding residues [nucleotide binding]
329726003167	FtsH Extracellular; Region: FtsH_ext; pfam06480
329726003168	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
329726003169	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726003170	Walker A motif; other site
329726003171	ATP binding site [chemical binding]; other site
329726003172	Walker B motif; other site
329726003173	arginine finger; other site
329726003174	Peptidase family M41; Region: Peptidase_M41; pfam01434
329726003175	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
329726003176	substrate binding site [chemical binding]; other site
329726003177	putative lipid kinase; Reviewed; Region: PRK00861
329726003178	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
329726003179	Predicted periplasmic protein [Function unknown]; Region: COG3904
329726003180	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
329726003181	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
329726003182	substrate binding pocket [chemical binding]; other site
329726003183	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726003184	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726003185	oxidoreductase; Provisional; Region: PRK06196
329726003186	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
329726003187	putative NAD(P) binding site [chemical binding]; other site
329726003188	active site
329726003189	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
329726003190	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726003191	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726003192	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
329726003193	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
329726003194	Transcriptional regulator [Transcription]; Region: LysR; COG0583
329726003195	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726003196	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
329726003197	substrate binding pocket [chemical binding]; other site
329726003198	dimerization interface [polypeptide binding]; other site
329726003199	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
329726003200	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
329726003201	active site
329726003202	catalytic tetrad [active]
329726003203	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726003204	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
329726003205	NAD(P) binding site [chemical binding]; other site
329726003206	active site
329726003207	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
329726003208	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
329726003209	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
329726003210	SnoaL-like domain; Region: SnoaL_2; pfam12680
329726003211	SnoaL-like domain; Region: SnoaL_2; pfam12680
329726003212	Homeodomain-like domain; Region: HTH_23; pfam13384
329726003213	Winged helix-turn helix; Region: HTH_29; pfam13551
329726003214	Winged helix-turn helix; Region: HTH_33; pfam13592
329726003215	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726003216	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726003217	SnoaL-like domain; Region: SnoaL_4; pfam13577
329726003218	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726003219	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726003220	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726003221	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726003222	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
329726003223	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
329726003224	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189
329726003225	putative active site [active]
329726003226	metal binding site [ion binding]; metal-binding site
329726003227	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
329726003228	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
329726003229	NAD(P) binding site [chemical binding]; other site
329726003230	catalytic residues [active]
329726003231	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
329726003232	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
329726003233	substrate binding site [chemical binding]; other site
329726003234	active site
329726003235	catalytic residues [active]
329726003236	heterodimer interface [polypeptide binding]; other site
329726003237	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
329726003238	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
329726003239	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
329726003240	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
329726003241	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
329726003242	trimer interface [polypeptide binding]; other site
329726003243	active site
329726003244	UDP-GlcNAc binding site [chemical binding]; other site
329726003245	lipid binding site [chemical binding]; lipid-binding site
329726003246	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
329726003247	HSP70 interaction site [polypeptide binding]; other site
329726003248	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
329726003249	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
329726003250	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
329726003251	tetramer interface [polypeptide binding]; other site
329726003252	TPP-binding site [chemical binding]; other site
329726003253	heterodimer interface [polypeptide binding]; other site
329726003254	phosphorylation loop region [posttranslational modification]
329726003255	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
329726003256	nudix motif; other site
329726003257	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
329726003258	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
329726003259	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726003260	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726003261	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726003262	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726003263	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726003264	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726003265	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
329726003266	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
329726003267	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726003268	Walker A motif; other site
329726003269	ATP binding site [chemical binding]; other site
329726003270	Walker B motif; other site
329726003271	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
329726003272	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
329726003273	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
329726003274	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
329726003275	Walker A/P-loop; other site
329726003276	ATP binding site [chemical binding]; other site
329726003277	Q-loop/lid; other site
329726003278	ABC transporter signature motif; other site
329726003279	Walker B; other site
329726003280	D-loop; other site
329726003281	H-loop/switch region; other site
329726003282	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
329726003283	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
329726003284	Walker A/P-loop; other site
329726003285	ATP binding site [chemical binding]; other site
329726003286	Q-loop/lid; other site
329726003287	ABC transporter signature motif; other site
329726003288	Walker B; other site
329726003289	D-loop; other site
329726003290	H-loop/switch region; other site
329726003291	Ferredoxin [Energy production and conversion]; Region: COG1146
329726003292	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
329726003293	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
329726003294	Walker A/P-loop; other site
329726003295	ATP binding site [chemical binding]; other site
329726003296	Q-loop/lid; other site
329726003297	ABC transporter signature motif; other site
329726003298	Walker B; other site
329726003299	D-loop; other site
329726003300	H-loop/switch region; other site
329726003301	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
329726003302	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
329726003303	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
329726003304	Photosystem II protein; Region: PSII; cl08223
329726003305	Photosystem II protein; Region: PSII; cl08223
329726003306	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
329726003307	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
329726003308	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
329726003309	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
329726003310	dimer interface [polypeptide binding]; other site
329726003311	motif 1; other site
329726003312	active site
329726003313	motif 2; other site
329726003314	motif 3; other site
329726003315	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
329726003316	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
329726003317	FMN binding site [chemical binding]; other site
329726003318	active site
329726003319	catalytic residues [active]
329726003320	substrate binding site [chemical binding]; other site
329726003321	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
329726003322	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
329726003323	active site
329726003324	Zn binding site [ion binding]; other site
329726003325	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726003326	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726003327	active site
329726003328	ATP binding site [chemical binding]; other site
329726003329	substrate binding site [chemical binding]; other site
329726003330	activation loop (A-loop); other site
329726003331	GUN4-like; Region: GUN4; pfam05419
329726003332	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726003333	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726003334	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
329726003335	dimer interface [polypeptide binding]; other site
329726003336	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
329726003337	putative CheW interface [polypeptide binding]; other site
329726003338	CheW-like domain; Region: CheW; pfam01584
329726003339	Response regulator receiver domain; Region: Response_reg; pfam00072
329726003340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726003341	active site
329726003342	phosphorylation site [posttranslational modification]
329726003343	intermolecular recognition site; other site
329726003344	dimerization interface [polypeptide binding]; other site
329726003345	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
329726003346	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
329726003347	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
329726003348	dimer interface [polypeptide binding]; other site
329726003349	putative functional site; other site
329726003350	putative MPT binding site; other site
329726003351	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
329726003352	AAA ATPase domain; Region: AAA_16; pfam13191
329726003353	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
329726003354	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
329726003355	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
329726003356	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
329726003357	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
329726003358	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
329726003359	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
329726003360	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726003361	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
329726003362	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
329726003363	active site
329726003364	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
329726003365	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
329726003366	SnoaL-like domain; Region: SnoaL_3; pfam13474
329726003367	Leucine rich repeat; Region: LRR_8; pfam13855
329726003368	fumarate hydratase; Reviewed; Region: fumC; PRK00485
329726003369	Class II fumarases; Region: Fumarase_classII; cd01362
329726003370	active site
329726003371	tetramer interface [polypeptide binding]; other site
329726003372	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
329726003373	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
329726003374	AMIN domain; Region: AMIN; pfam11741
329726003375	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
329726003376	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
329726003377	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
329726003378	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
329726003379	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
329726003380	substrate binding site [chemical binding]; other site
329726003381	hexamer interface [polypeptide binding]; other site
329726003382	metal binding site [ion binding]; metal-binding site
329726003383	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
329726003384	Mechanosensitive ion channel; Region: MS_channel; pfam00924
329726003385	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726003386	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726003387	ligand binding site [chemical binding]; other site
329726003388	flexible hinge region; other site
329726003389	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726003390	dimerization interface [polypeptide binding]; other site
329726003391	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
329726003392	cyclase homology domain; Region: CHD; cd07302
329726003393	nucleotidyl binding site; other site
329726003394	metal binding site [ion binding]; metal-binding site
329726003395	dimer interface [polypeptide binding]; other site
329726003396	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
329726003397	ABC1 family; Region: ABC1; cl17513
329726003398	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
329726003399	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
329726003400	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
329726003401	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
329726003402	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
329726003403	TPR repeat; Region: TPR_11; pfam13414
329726003404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003405	binding surface
329726003406	TPR motif; other site
329726003407	TPR repeat; Region: TPR_11; pfam13414
329726003408	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726003409	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003410	binding surface
329726003411	TPR motif; other site
329726003412	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003413	binding surface
329726003414	TPR motif; other site
329726003415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003416	binding surface
329726003417	TPR motif; other site
329726003418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003419	TPR motif; other site
329726003420	TPR repeat; Region: TPR_11; pfam13414
329726003421	binding surface
329726003422	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
329726003423	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
329726003424	metal binding site [ion binding]; metal-binding site
329726003425	dimer interface [polypeptide binding]; other site
329726003426	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
329726003427	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
329726003428	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
329726003429	active site
329726003430	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
329726003431	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
329726003432	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
329726003433	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
329726003434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
329726003435	Uncharacterized conserved protein [Function unknown]; Region: COG2308
329726003436	Cupin domain; Region: Cupin_2; cl17218
329726003437	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726003438	PAS domain; Region: PAS_9; pfam13426
329726003439	putative active site [active]
329726003440	heme pocket [chemical binding]; other site
329726003441	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726003442	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726003443	putative active site [active]
329726003444	heme pocket [chemical binding]; other site
329726003445	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726003446	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726003447	metal binding site [ion binding]; metal-binding site
329726003448	active site
329726003449	I-site; other site
329726003450	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726003451	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
329726003452	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
329726003453	Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709
329726003454	dimerization interface [polypeptide binding]; other site
329726003455	putative ATP binding site [chemical binding]; other site
329726003456	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
329726003457	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
329726003458	Dynamin family; Region: Dynamin_N; pfam00350
329726003459	G1 box; other site
329726003460	GTP/Mg2+ binding site [chemical binding]; other site
329726003461	G2 box; other site
329726003462	Switch I region; other site
329726003463	G3 box; other site
329726003464	Switch II region; other site
329726003465	G4 box; other site
329726003466	G5 box; other site
329726003467	AAA ATPase domain; Region: AAA_16; pfam13191
329726003468	NACHT domain; Region: NACHT; pfam05729
329726003469	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726003470	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726003471	structural tetrad; other site
329726003472	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726003473	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726003474	structural tetrad; other site
329726003475	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726003476	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
329726003477	Dynamin family; Region: Dynamin_N; pfam00350
329726003478	G1 box; other site
329726003479	GTP/Mg2+ binding site [chemical binding]; other site
329726003480	G2 box; other site
329726003481	Switch I region; other site
329726003482	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
329726003483	G3 box; other site
329726003484	Switch II region; other site
329726003485	GTP/Mg2+ binding site [chemical binding]; other site
329726003486	G4 box; other site
329726003487	G5 box; other site
329726003488	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
329726003489	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
329726003490	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726003491	motif II; other site
329726003492	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
329726003493	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
329726003494	Part of AAA domain; Region: AAA_19; pfam13245
329726003495	Family description; Region: UvrD_C_2; pfam13538
329726003496	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
329726003497	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
329726003498	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
329726003499	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
329726003500	glutamine binding [chemical binding]; other site
329726003501	catalytic triad [active]
329726003502	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
329726003503	metal-binding heat shock protein; Provisional; Region: PRK00016
329726003504	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
329726003505	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
329726003506	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
329726003507	putative active site [active]
329726003508	catalytic triad [active]
329726003509	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
329726003510	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
329726003511	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
329726003512	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
329726003513	Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605
329726003514	Uncharacterized conserved protein [Function unknown]; Region: COG0062
329726003515	putative carbohydrate kinase; Provisional; Region: PRK10565
329726003516	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
329726003517	putative substrate binding site [chemical binding]; other site
329726003518	putative ATP binding site [chemical binding]; other site
329726003519	Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320
329726003520	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
329726003521	UGMP family protein; Validated; Region: PRK09604
329726003522	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
329726003523	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
329726003524	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
329726003525	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
329726003526	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
329726003527	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
329726003528	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
329726003529	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
329726003530	P-loop; other site
329726003531	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
329726003532	hydrophobic ligand binding site; other site
329726003533	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
329726003534	antiporter inner membrane protein; Provisional; Region: PRK11670
329726003535	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
329726003536	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
329726003537	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
329726003538	RDD family; Region: RDD; pfam06271
329726003539	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
329726003540	RNA binding site [nucleotide binding]; other site
329726003541	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
329726003542	RNA binding site [nucleotide binding]; other site
329726003543	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
329726003544	RNA binding site [nucleotide binding]; other site
329726003545	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
329726003546	Fasciclin domain; Region: Fasciclin; pfam02469
329726003547	AAA domain; Region: AAA_18; pfam13238
329726003548	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
329726003549	acetylornithine aminotransferase; Provisional; Region: PRK02627
329726003550	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
329726003551	inhibitor-cofactor binding pocket; inhibition site
329726003552	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726003553	catalytic residue [active]
329726003554	Staphylococcal nuclease homologues; Region: SNc; smart00318
329726003555	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
329726003556	Catalytic site; other site
329726003557	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
329726003558	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
329726003559	putative dimer interface [polypeptide binding]; other site
329726003560	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
329726003561	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
329726003562	potential catalytic triad [active]
329726003563	conserved cys residue [active]
329726003564	CHASE3 domain; Region: CHASE3; pfam05227
329726003565	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726003566	HAMP domain; Region: HAMP; pfam00672
329726003567	dimerization interface [polypeptide binding]; other site
329726003568	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726003569	dimer interface [polypeptide binding]; other site
329726003570	phosphorylation site [posttranslational modification]
329726003571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726003572	ATP binding site [chemical binding]; other site
329726003573	Mg2+ binding site [ion binding]; other site
329726003574	G-X-G motif; other site
329726003575	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726003576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726003577	active site
329726003578	phosphorylation site [posttranslational modification]
329726003579	intermolecular recognition site; other site
329726003580	dimerization interface [polypeptide binding]; other site
329726003581	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726003582	DNA binding residues [nucleotide binding]
329726003583	dimerization interface [polypeptide binding]; other site
329726003584	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337
329726003585	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
329726003586	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726003587	Coenzyme A binding pocket [chemical binding]; other site
329726003588	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726003589	carotene isomerase; Region: carot_isom; TIGR02730
329726003590	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
329726003591	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
329726003592	active site flap/lid [active]
329726003593	nucleophilic elbow; other site
329726003594	catalytic triad [active]
329726003595	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
329726003596	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
329726003597	Walker A/P-loop; other site
329726003598	ATP binding site [chemical binding]; other site
329726003599	Q-loop/lid; other site
329726003600	ABC transporter signature motif; other site
329726003601	Walker B; other site
329726003602	D-loop; other site
329726003603	H-loop/switch region; other site
329726003604	TOBE domain; Region: TOBE_2; pfam08402
329726003605	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726003606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726003607	active site
329726003608	phosphorylation site [posttranslational modification]
329726003609	intermolecular recognition site; other site
329726003610	dimerization interface [polypeptide binding]; other site
329726003611	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726003612	DNA binding site [nucleotide binding]
329726003613	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
329726003614	HAMP domain; Region: HAMP; pfam00672
329726003615	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726003616	dimer interface [polypeptide binding]; other site
329726003617	phosphorylation site [posttranslational modification]
329726003618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726003619	ATP binding site [chemical binding]; other site
329726003620	Mg2+ binding site [ion binding]; other site
329726003621	G-X-G motif; other site
329726003622	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
329726003623	YGGT family; Region: YGGT; pfam02325
329726003624	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
329726003625	active site
329726003626	carotene isomerase; Region: carot_isom; TIGR02730
329726003627	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726003628	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
329726003629	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
329726003630	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
329726003631	Predicted dehydrogenase [General function prediction only]; Region: COG5322
329726003632	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
329726003633	glutamine synthetase, type I; Region: GlnA; TIGR00653
329726003634	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
329726003635	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
329726003636	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726003637	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726003638	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726003639	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726003640	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726003641	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726003642	GAF domain; Region: GAF; pfam01590
329726003643	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726003644	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726003645	dimer interface [polypeptide binding]; other site
329726003646	phosphorylation site [posttranslational modification]
329726003647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726003648	ATP binding site [chemical binding]; other site
329726003649	Mg2+ binding site [ion binding]; other site
329726003650	G-X-G motif; other site
329726003651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726003652	Response regulator receiver domain; Region: Response_reg; pfam00072
329726003653	active site
329726003654	phosphorylation site [posttranslational modification]
329726003655	intermolecular recognition site; other site
329726003656	dimerization interface [polypeptide binding]; other site
329726003657	Response regulator receiver domain; Region: Response_reg; pfam00072
329726003658	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726003659	active site
329726003660	phosphorylation site [posttranslational modification]
329726003661	intermolecular recognition site; other site
329726003662	dimerization interface [polypeptide binding]; other site
329726003663	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
329726003664	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726003665	putative active site [active]
329726003666	heme pocket [chemical binding]; other site
329726003667	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726003668	dimer interface [polypeptide binding]; other site
329726003669	phosphorylation site [posttranslational modification]
329726003670	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726003671	ATP binding site [chemical binding]; other site
329726003672	Mg2+ binding site [ion binding]; other site
329726003673	G-X-G motif; other site
329726003674	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726003675	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726003676	active site
329726003677	phosphorylation site [posttranslational modification]
329726003678	intermolecular recognition site; other site
329726003679	dimerization interface [polypeptide binding]; other site
329726003680	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726003681	DNA binding site [nucleotide binding]
329726003682	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
329726003683	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
329726003684	glucosamine-fructose-6-phosphate aminotransferase; Provisional; Region: PTZ00394
329726003685	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
329726003686	MgtE intracellular N domain; Region: MgtE_N; smart00924
329726003687	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
329726003688	Divalent cation transporter; Region: MgtE; pfam01769
329726003689	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
329726003690	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
329726003691	intersubunit interface [polypeptide binding]; other site
329726003692	active site
329726003693	zinc binding site [ion binding]; other site
329726003694	Na+ binding site [ion binding]; other site
329726003695	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726003696	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
329726003697	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726003698	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
329726003699	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
329726003700	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726003701	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726003702	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
329726003703	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
329726003704	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
329726003705	catalytic residues [active]
329726003706	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726003707	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726003708	Coenzyme A binding pocket [chemical binding]; other site
329726003709	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
329726003710	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
329726003711	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
329726003712	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
329726003713	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
329726003714	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
329726003715	putative NAD(P) binding site [chemical binding]; other site
329726003716	catalytic Zn binding site [ion binding]; other site
329726003717	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
329726003718	Fatty acid desaturase; Region: FA_desaturase; pfam00487
329726003719	Di-iron ligands [ion binding]; other site
329726003720	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
329726003721	Aluminium resistance protein; Region: Alum_res; pfam06838
329726003722	NifU-like domain; Region: NifU; pfam01106
329726003723	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
329726003724	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
329726003725	lipoyl attachment site [posttranslational modification]; other site
329726003726	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
329726003727	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
329726003728	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
329726003729	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726003730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726003731	S-adenosylmethionine binding site [chemical binding]; other site
329726003732	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
329726003733	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
329726003734	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
329726003735	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
329726003736	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
329726003737	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
329726003738	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
329726003739	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
329726003740	active site
329726003741	dimer interface [polypeptide binding]; other site
329726003742	motif 1; other site
329726003743	motif 2; other site
329726003744	motif 3; other site
329726003745	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
329726003746	anticodon binding site; other site
329726003747	Homeodomain-like domain; Region: HTH_23; cl17451
329726003748	Caspase domain; Region: Peptidase_C14; pfam00656
329726003749	GUN4-like; Region: GUN4; pfam05419
329726003750	Homeodomain-like domain; Region: HTH_23; pfam13384
329726003751	Winged helix-turn helix; Region: HTH_29; pfam13551
329726003752	Homeodomain-like domain; Region: HTH_32; pfam13565
329726003753	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
329726003754	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
329726003755	Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053
329726003756	diiron binding motif [ion binding]; other site
329726003757	Predicted transcriptional regulators [Transcription]; Region: COG1733
329726003758	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
329726003759	putative Zn2+ binding site [ion binding]; other site
329726003760	putative DNA binding site [nucleotide binding]; other site
329726003761	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
329726003762	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
329726003763	substrate binding pocket [chemical binding]; other site
329726003764	membrane-bound complex binding site; other site
329726003765	hinge residues; other site
329726003766	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
329726003767	Cation efflux family; Region: Cation_efflux; cl00316
329726003768	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726003769	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726003770	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726003771	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726003772	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726003773	dimer interface [polypeptide binding]; other site
329726003774	phosphorylation site [posttranslational modification]
329726003775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726003776	ATP binding site [chemical binding]; other site
329726003777	Mg2+ binding site [ion binding]; other site
329726003778	G-X-G motif; other site
329726003779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726003780	Response regulator receiver domain; Region: Response_reg; pfam00072
329726003781	active site
329726003782	phosphorylation site [posttranslational modification]
329726003783	intermolecular recognition site; other site
329726003784	dimerization interface [polypeptide binding]; other site
329726003785	Phycobilisome protein; Region: Phycobilisome; cl08227
329726003786	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726003787	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726003788	catalytic loop [active]
329726003789	iron binding site [ion binding]; other site
329726003790	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
329726003791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
329726003792	Calx-beta domain; Region: Calx-beta; cl02522
329726003793	Calx-beta domain; Region: Calx-beta; cl02522
329726003794	Calx-beta domain; Region: Calx-beta; cl02522
329726003795	Calx-beta domain; Region: Calx-beta; cl02522
329726003796	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
329726003797	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
329726003798	DNA binding residues [nucleotide binding]
329726003799	putative dimer interface [polypeptide binding]; other site
329726003800	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
329726003801	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
329726003802	Histidine kinase; Region: HisKA_3; pfam07730
329726003803	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726003804	ATP binding site [chemical binding]; other site
329726003805	Mg2+ binding site [ion binding]; other site
329726003806	G-X-G motif; other site
329726003807	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726003808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726003809	active site
329726003810	phosphorylation site [posttranslational modification]
329726003811	intermolecular recognition site; other site
329726003812	dimerization interface [polypeptide binding]; other site
329726003813	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726003814	DNA binding residues [nucleotide binding]
329726003815	dimerization interface [polypeptide binding]; other site
329726003816	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
329726003817	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726003818	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
329726003819	Coenzyme A binding pocket [chemical binding]; other site
329726003820	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726003821	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726003822	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726003823	Coenzyme A binding pocket [chemical binding]; other site
329726003824	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003825	binding surface
329726003826	TPR motif; other site
329726003827	TPR repeat; Region: TPR_11; pfam13414
329726003828	TPR repeat; Region: TPR_11; pfam13414
329726003829	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003830	binding surface
329726003831	TPR motif; other site
329726003832	Tetratricopeptide repeat; Region: TPR_16; pfam13432
329726003833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
329726003834	binding surface
329726003835	TPR motif; other site
329726003836	tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167
329726003837	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
329726003838	active site residue [active]
329726003839	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726003840	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726003841	active site
329726003842	ATP binding site [chemical binding]; other site
329726003843	substrate binding site [chemical binding]; other site
329726003844	activation loop (A-loop); other site
329726003845	Tetratricopeptide repeat; Region: TPR_1; pfam00515
329726003846	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726003847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003848	binding surface
329726003849	TPR motif; other site
329726003850	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003851	binding surface
329726003852	TPR motif; other site
329726003853	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003854	binding surface
329726003855	TPR motif; other site
329726003856	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
329726003857	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726003858	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726003859	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726003860	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726003861	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726003862	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726003863	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726003864	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726003865	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726003866	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
329726003867	GXWXG protein; Region: GXWXG; pfam14231
329726003868	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
329726003869	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726003870	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726003871	active site
329726003872	ATP binding site [chemical binding]; other site
329726003873	substrate binding site [chemical binding]; other site
329726003874	activation loop (A-loop); other site
329726003875	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003876	binding surface
329726003877	TPR motif; other site
329726003878	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726003879	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003880	binding surface
329726003881	TPR motif; other site
329726003882	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726003883	binding surface
329726003884	TPR motif; other site
329726003885	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
329726003886	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
329726003887	putative NADP binding site [chemical binding]; other site
329726003888	putative substrate binding site [chemical binding]; other site
329726003889	active site
329726003890	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726003891	Walker B; other site
329726003892	D-loop; other site
329726003893	H-loop/switch region; other site
329726003894	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
329726003895	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726003896	ABC transporter signature motif; other site
329726003897	Walker B; other site
329726003898	D-loop; other site
329726003899	H-loop/switch region; other site
329726003900	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726003901	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726003902	FtsH Extracellular; Region: FtsH_ext; pfam06480
329726003903	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
329726003904	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726003905	Walker A motif; other site
329726003906	ATP binding site [chemical binding]; other site
329726003907	Walker B motif; other site
329726003908	arginine finger; other site
329726003909	Peptidase family M41; Region: Peptidase_M41; pfam01434
329726003910	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
329726003911	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
329726003912	Walker A/P-loop; other site
329726003913	ATP binding site [chemical binding]; other site
329726003914	Q-loop/lid; other site
329726003915	ABC transporter signature motif; other site
329726003916	Walker B; other site
329726003917	D-loop; other site
329726003918	H-loop/switch region; other site
329726003919	DevC protein; Region: devC; TIGR01185
329726003920	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
329726003921	FtsX-like permease family; Region: FtsX; pfam02687
329726003922	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
329726003923	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726003924	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726003925	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
329726003926	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
329726003927	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
329726003928	C-terminal domain interface [polypeptide binding]; other site
329726003929	GSH binding site (G-site) [chemical binding]; other site
329726003930	dimer interface [polypeptide binding]; other site
329726003931	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
329726003932	N-terminal domain interface [polypeptide binding]; other site
329726003933	dimer interface [polypeptide binding]; other site
329726003934	substrate binding pocket (H-site) [chemical binding]; other site
329726003935	Predicted transcriptional regulators [Transcription]; Region: COG1733
329726003936	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
329726003937	dimerization interface [polypeptide binding]; other site
329726003938	putative DNA binding site [nucleotide binding]; other site
329726003939	putative Zn2+ binding site [ion binding]; other site
329726003940	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
329726003941	Homeodomain-like domain; Region: HTH_23; pfam13384
329726003942	Winged helix-turn helix; Region: HTH_29; pfam13551
329726003943	Homeodomain-like domain; Region: HTH_32; pfam13565
329726003944	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726003945	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726003946	Transcriptional regulator [Transcription]; Region: LysR; COG0583
329726003947	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726003948	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
329726003949	putative effector binding pocket; other site
329726003950	dimerization interface [polypeptide binding]; other site
329726003951	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
329726003952	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
329726003953	putative NAD(P) binding site [chemical binding]; other site
329726003954	dimer interface [polypeptide binding]; other site
329726003955	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
329726003956	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
329726003957	substrate binding site [chemical binding]; other site
329726003958	oxyanion hole (OAH) forming residues; other site
329726003959	trimer interface [polypeptide binding]; other site
329726003960	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
329726003961	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
329726003962	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
329726003963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726003964	NAD(P) binding site [chemical binding]; other site
329726003965	active site
329726003966	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
329726003967	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726003968	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726003969	metal binding site [ion binding]; metal-binding site
329726003970	active site
329726003971	I-site; other site
329726003972	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
329726003973	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
329726003974	substrate binding site [chemical binding]; other site
329726003975	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
329726003976	substrate binding site [chemical binding]; other site
329726003977	ligand binding site [chemical binding]; other site
329726003978	D-cysteine desulfhydrase; Validated; Region: PRK03910
329726003979	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
329726003980	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
329726003981	catalytic residue [active]
329726003982	photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049
329726003983	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
329726003984	active site
329726003985	Response regulator receiver domain; Region: Response_reg; pfam00072
329726003986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726003987	active site
329726003988	phosphorylation site [posttranslational modification]
329726003989	intermolecular recognition site; other site
329726003990	dimerization interface [polypeptide binding]; other site
329726003991	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726003992	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726003993	metal binding site [ion binding]; metal-binding site
329726003994	active site
329726003995	I-site; other site
329726003996	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
329726003997	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
329726003998	quinone interaction residues [chemical binding]; other site
329726003999	active site
329726004000	catalytic residues [active]
329726004001	FMN binding site [chemical binding]; other site
329726004002	substrate binding site [chemical binding]; other site
329726004003	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
329726004004	active site
329726004005	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
329726004006	phosphoglyceromutase; Provisional; Region: PRK05434
329726004007	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
329726004008	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
329726004009	phosphoenolpyruvate synthase; Validated; Region: PRK06464
329726004010	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
329726004011	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
329726004012	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
329726004013	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726004014	Ligand Binding Site [chemical binding]; other site
329726004015	Response regulator receiver domain; Region: Response_reg; pfam00072
329726004016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726004017	active site
329726004018	phosphorylation site [posttranslational modification]
329726004019	intermolecular recognition site; other site
329726004020	dimerization interface [polypeptide binding]; other site
329726004021	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
329726004022	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
329726004023	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
329726004024	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726004025	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726004026	catalytic loop [active]
329726004027	iron binding site [ion binding]; other site
329726004028	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
329726004029	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
329726004030	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
329726004031	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
329726004032	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726004033	Walker A motif; other site
329726004034	ATP binding site [chemical binding]; other site
329726004035	Walker B motif; other site
329726004036	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
329726004037	RxxxH motif; other site
329726004038	Class I aldolases; Region: Aldolase_Class_I; cl17187
329726004039	catalytic residue [active]
329726004040	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
329726004041	substrate binding site [chemical binding]; other site
329726004042	activation loop (A-loop); other site
329726004043	AAA ATPase domain; Region: AAA_16; pfam13191
329726004044	Predicted ATPase [General function prediction only]; Region: COG3899
329726004045	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726004046	GAF domain; Region: GAF; pfam01590
329726004047	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726004048	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726004049	dimer interface [polypeptide binding]; other site
329726004050	phosphorylation site [posttranslational modification]
329726004051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726004052	ATP binding site [chemical binding]; other site
329726004053	Mg2+ binding site [ion binding]; other site
329726004054	G-X-G motif; other site
329726004055	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726004056	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726004057	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726004058	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
329726004059	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
329726004060	arginine decarboxylase; Provisional; Region: PRK05354
329726004061	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
329726004062	active site
329726004063	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
329726004064	catalytic residues [active]
329726004065	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
329726004066	photosystem I subunit VII; Region: psaC; CHL00065
329726004067	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
329726004068	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
329726004069	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
329726004070	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
329726004071	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
329726004072	active site
329726004073	dimer interface [polypeptide binding]; other site
329726004074	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
329726004075	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
329726004076	active site
329726004077	FMN binding site [chemical binding]; other site
329726004078	substrate binding site [chemical binding]; other site
329726004079	3Fe-4S cluster binding site [ion binding]; other site
329726004080	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
329726004081	domain interface; other site
329726004082	RloB-like protein; Region: RloB; pfam13707
329726004083	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
329726004084	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
329726004085	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
329726004086	putative active site [active]
329726004087	putative dimer interface [polypeptide binding]; other site
329726004088	adenylosuccinate lyase; Reviewed; Region: PRK08540
329726004089	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
329726004090	active site
329726004091	catalytic triad [active]
329726004092	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
329726004093	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726004094	putative active site [active]
329726004095	recombination protein F; Reviewed; Region: recF; PRK00064
329726004096	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
329726004097	Walker A/P-loop; other site
329726004098	ATP binding site [chemical binding]; other site
329726004099	Q-loop/lid; other site
329726004100	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726004101	ABC transporter signature motif; other site
329726004102	Walker B; other site
329726004103	D-loop; other site
329726004104	H-loop/switch region; other site
329726004105	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
329726004106	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
329726004107	catalytic site [active]
329726004108	putative active site [active]
329726004109	putative substrate binding site [chemical binding]; other site
329726004110	YciI-like protein; Reviewed; Region: PRK12864
329726004111	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
329726004112	ABC1 family; Region: ABC1; cl17513
329726004113	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
329726004114	glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398
329726004115	active site
329726004116	homotetramer interface [polypeptide binding]; other site
329726004117	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
329726004118	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
329726004119	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
329726004120	N- and C-terminal domain interface [polypeptide binding]; other site
329726004121	active site
329726004122	MgATP binding site [chemical binding]; other site
329726004123	catalytic site [active]
329726004124	metal binding site [ion binding]; metal-binding site
329726004125	glycerol binding site [chemical binding]; other site
329726004126	homotetramer interface [polypeptide binding]; other site
329726004127	homodimer interface [polypeptide binding]; other site
329726004128	FBP binding site [chemical binding]; other site
329726004129	protein IIAGlc interface [polypeptide binding]; other site
329726004130	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726004131	Calx-beta domain; Region: Calx-beta; cl02522
329726004132	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
329726004133	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
329726004134	legume lectins; Region: lectin_L-type; cd01951
329726004135	homotetramer interaction site [polypeptide binding]; other site
329726004136	carbohydrate binding site [chemical binding]; other site
329726004137	metal binding site [ion binding]; metal-binding site
329726004138	glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399
329726004139	Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506
329726004140	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
329726004141	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
329726004142	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
329726004143	Putative integral membrane protein DUF46; Region: DUF46; cl17511
329726004144	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
329726004145	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
329726004146	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
329726004147	lipoyl synthase; Provisional; Region: PRK12928
329726004148	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726004149	FeS/SAM binding site; other site
329726004150	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
329726004151	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
329726004152	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726004153	FeS/SAM binding site; other site
329726004154	TRAM domain; Region: TRAM; cl01282
329726004155	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
329726004156	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
329726004157	ATP binding site [chemical binding]; other site
329726004158	Mg++ binding site [ion binding]; other site
329726004159	motif III; other site
329726004160	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726004161	nucleotide binding region [chemical binding]; other site
329726004162	ATP-binding site [chemical binding]; other site
329726004163	Transglycosylase; Region: Transgly; pfam00912
329726004164	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
329726004165	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
329726004166	cobalamin synthase; Reviewed; Region: cobS; PRK00235
329726004167	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
329726004168	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
329726004169	homodimer interface [polypeptide binding]; other site
329726004170	oligonucleotide binding site [chemical binding]; other site
329726004171	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
329726004172	Predicted transcriptional regulators [Transcription]; Region: COG1725
329726004173	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
329726004174	DNA-binding site [nucleotide binding]; DNA binding site
329726004175	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
329726004176	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
329726004177	metal ion-dependent adhesion site (MIDAS); other site
329726004178	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
329726004179	Peptidase family M50; Region: Peptidase_M50; pfam02163
329726004180	active site
329726004181	putative substrate binding region [chemical binding]; other site
329726004182	TPR repeat; Region: TPR_11; pfam13414
329726004183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726004184	binding surface
329726004185	TPR motif; other site
329726004186	TPR repeat; Region: TPR_11; pfam13414
329726004187	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
329726004188	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
329726004189	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
329726004190	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
329726004191	Sporulation related domain; Region: SPOR; cl10051
329726004192	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
329726004193	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
329726004194	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
329726004195	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
329726004196	dimerization interface [polypeptide binding]; other site
329726004197	active site
329726004198	metal binding site [ion binding]; metal-binding site
329726004199	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
329726004200	cytochrome c biogenesis protein; Region: ccsA; CHL00045
329726004201	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
329726004202	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
329726004203	HSP70 interaction site [polypeptide binding]; other site
329726004204	TPR repeat; Region: TPR_11; pfam13414
329726004205	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726004206	binding surface
329726004207	TPR motif; other site
329726004208	TPR repeat; Region: TPR_11; pfam13414
329726004209	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
329726004210	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
329726004211	Ligand Binding Site [chemical binding]; other site
329726004212	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726004213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726004214	active site
329726004215	phosphorylation site [posttranslational modification]
329726004216	intermolecular recognition site; other site
329726004217	dimerization interface [polypeptide binding]; other site
329726004218	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726004219	DNA binding site [nucleotide binding]
329726004220	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
329726004221	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726004222	motif II; other site
329726004223	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
329726004224	Response regulator receiver domain; Region: Response_reg; pfam00072
329726004225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726004226	active site
329726004227	phosphorylation site [posttranslational modification]
329726004228	intermolecular recognition site; other site
329726004229	dimerization interface [polypeptide binding]; other site
329726004230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726004231	PAS fold; Region: PAS_3; pfam08447
329726004232	putative active site [active]
329726004233	heme pocket [chemical binding]; other site
329726004234	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726004235	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726004236	metal binding site [ion binding]; metal-binding site
329726004237	active site
329726004238	I-site; other site
329726004239	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726004240	Response regulator receiver domain; Region: Response_reg; pfam00072
329726004241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726004242	active site
329726004243	phosphorylation site [posttranslational modification]
329726004244	intermolecular recognition site; other site
329726004245	dimerization interface [polypeptide binding]; other site
329726004246	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726004247	dimer interface [polypeptide binding]; other site
329726004248	phosphorylation site [posttranslational modification]
329726004249	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726004250	ATP binding site [chemical binding]; other site
329726004251	Mg2+ binding site [ion binding]; other site
329726004252	G-X-G motif; other site
329726004253	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
329726004254	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
329726004255	trmE is a tRNA modification GTPase; Region: trmE; cd04164
329726004256	G1 box; other site
329726004257	GTP/Mg2+ binding site [chemical binding]; other site
329726004258	Switch I region; other site
329726004259	G2 box; other site
329726004260	Switch II region; other site
329726004261	G3 box; other site
329726004262	G4 box; other site
329726004263	G5 box; other site
329726004264	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
329726004265	spermidine synthase; Provisional; Region: PRK03612
329726004266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726004267	S-adenosylmethionine binding site [chemical binding]; other site
329726004268	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
329726004269	biotin synthase; Region: bioB; TIGR00433
329726004270	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726004271	FeS/SAM binding site; other site
329726004272	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
329726004273	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
329726004274	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
329726004275	active site
329726004276	HIGH motif; other site
329726004277	dimer interface [polypeptide binding]; other site
329726004278	KMSKS motif; other site
329726004279	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
329726004280	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726004281	GAF domain; Region: GAF; pfam01590
329726004282	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726004283	dimer interface [polypeptide binding]; other site
329726004284	phosphorylation site [posttranslational modification]
329726004285	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726004286	ATP binding site [chemical binding]; other site
329726004287	Mg2+ binding site [ion binding]; other site
329726004288	G-X-G motif; other site
329726004289	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
329726004290	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
329726004291	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
329726004292	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
329726004293	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
329726004294	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
329726004295	Ycf35; Provisional; Region: ycf35; CHL00193
329726004296	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
329726004297	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
329726004298	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
329726004299	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726004300	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726004301	Walker A/P-loop; other site
329726004302	ATP binding site [chemical binding]; other site
329726004303	Q-loop/lid; other site
329726004304	ABC transporter signature motif; other site
329726004305	Walker B; other site
329726004306	D-loop; other site
329726004307	H-loop/switch region; other site
329726004308	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726004309	phosphopeptide binding site; other site
329726004310	Transglycosylase; Region: Transgly; pfam00912
329726004311	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
329726004312	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
329726004313	Cytochrome c; Region: Cytochrom_C; pfam00034
329726004314	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
329726004315	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
329726004316	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
329726004317	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
329726004318	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
329726004319	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
329726004320	active site
329726004321	TDP-binding site; other site
329726004322	acceptor substrate-binding pocket; other site
329726004323	homodimer interface [polypeptide binding]; other site
329726004324	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726004325	putative active site [active]
329726004326	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
329726004327	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
329726004328	putative metal binding site [ion binding]; other site
329726004329	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
329726004330	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
329726004331	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
329726004332	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
329726004333	S-adenosylmethionine binding site [chemical binding]; other site
329726004334	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
329726004335	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
329726004336	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726004337	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
329726004338	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
329726004339	putative active site [active]
329726004340	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726004341	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726004342	Walker A/P-loop; other site
329726004343	ATP binding site [chemical binding]; other site
329726004344	Q-loop/lid; other site
329726004345	ABC transporter signature motif; other site
329726004346	Walker B; other site
329726004347	D-loop; other site
329726004348	H-loop/switch region; other site
329726004349	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
329726004350	Tetratricopeptide repeat; Region: TPR_16; pfam13432
329726004351	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726004352	binding surface
329726004353	TPR motif; other site
329726004354	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
329726004355	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
329726004356	G1 box; other site
329726004357	GTP/Mg2+ binding site [chemical binding]; other site
329726004358	Switch I region; other site
329726004359	G2 box; other site
329726004360	Switch II region; other site
329726004361	G3 box; other site
329726004362	G4 box; other site
329726004363	G5 box; other site
329726004364	Domain of unknown function (DUF697); Region: DUF697; pfam05128
329726004365	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
329726004366	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
329726004367	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726004368	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
329726004369	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
329726004370	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
329726004371	molybdopterin cofactor binding site; other site
329726004372	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
329726004373	molybdopterin cofactor binding site; other site
329726004374	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726004375	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726004376	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
329726004377	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726004378	DNA binding site [nucleotide binding]
329726004379	active site
329726004380	Int/Topo IB signature motif; other site
329726004381	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726004382	ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020
329726004383	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cl01843
329726004384	putative multimerization interface [polypeptide binding]; other site
329726004385	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
329726004386	active site
329726004387	catalytic triad [active]
329726004388	oxyanion hole [active]
329726004389	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
329726004390	multimerization interface [polypeptide binding]; other site
329726004391	RbcX protein; Region: RcbX; pfam02341
329726004392	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
329726004393	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
329726004394	homodimer interface [polypeptide binding]; other site
329726004395	active site
329726004396	heterodimer interface [polypeptide binding]; other site
329726004397	catalytic residue [active]
329726004398	metal binding site [ion binding]; metal-binding site
329726004399	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726004400	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726004401	Coenzyme A binding pocket [chemical binding]; other site
329726004402	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726004403	TPR repeat; Region: TPR_11; pfam13414
329726004404	binding surface
329726004405	TPR motif; other site
329726004406	TPR repeat; Region: TPR_11; pfam13414
329726004407	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726004408	binding surface
329726004409	TPR motif; other site
329726004410	TPR repeat; Region: TPR_11; pfam13414
329726004411	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726004412	binding surface
329726004413	TPR repeat; Region: TPR_11; pfam13414
329726004414	TPR motif; other site
329726004415	DnaJ domain; Region: DnaJ; pfam00226
329726004416	HSP70 interaction site [polypeptide binding]; other site
329726004417	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
329726004418	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
329726004419	putative active site [active]
329726004420	catalytic triad [active]
329726004421	putative dimer interface [polypeptide binding]; other site
329726004422	Uncharacterized conserved protein [Function unknown]; Region: COG3937
329726004423	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
329726004424	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
329726004425	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
329726004426	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
329726004427	elongation factor Tu; Region: tufA; CHL00071
329726004428	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
329726004429	G1 box; other site
329726004430	GEF interaction site [polypeptide binding]; other site
329726004431	GTP/Mg2+ binding site [chemical binding]; other site
329726004432	Switch I region; other site
329726004433	G2 box; other site
329726004434	G3 box; other site
329726004435	Switch II region; other site
329726004436	G4 box; other site
329726004437	G5 box; other site
329726004438	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
329726004439	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
329726004440	Antibiotic Binding Site [chemical binding]; other site
329726004441	elongation factor G; Reviewed; Region: PRK00007
329726004442	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
329726004443	G1 box; other site
329726004444	putative GEF interaction site [polypeptide binding]; other site
329726004445	GTP/Mg2+ binding site [chemical binding]; other site
329726004446	Switch I region; other site
329726004447	G2 box; other site
329726004448	G3 box; other site
329726004449	Switch II region; other site
329726004450	G4 box; other site
329726004451	G5 box; other site
329726004452	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
329726004453	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
329726004454	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
329726004455	30S ribosomal protein S7; Validated; Region: PRK05302
329726004456	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
329726004457	S17 interaction site [polypeptide binding]; other site
329726004458	S8 interaction site; other site
329726004459	16S rRNA interaction site [nucleotide binding]; other site
329726004460	streptomycin interaction site [chemical binding]; other site
329726004461	23S rRNA interaction site [nucleotide binding]; other site
329726004462	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
329726004463	hypothetical protein; Validated; Region: PRK00153
329726004464	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
329726004465	FAD binding domain; Region: FAD_binding_4; pfam01565
329726004466	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
329726004467	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
329726004468	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
329726004469	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
329726004470	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
329726004471	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
329726004472	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
329726004473	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
329726004474	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
329726004475	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
329726004476	putative binding surface; other site
329726004477	active site
329726004478	GTPase CgtA; Reviewed; Region: obgE; PRK12299
329726004479	GTP1/OBG; Region: GTP1_OBG; pfam01018
329726004480	Obg GTPase; Region: Obg; cd01898
329726004481	G1 box; other site
329726004482	GTP/Mg2+ binding site [chemical binding]; other site
329726004483	Switch I region; other site
329726004484	G2 box; other site
329726004485	G3 box; other site
329726004486	Switch II region; other site
329726004487	G4 box; other site
329726004488	G5 box; other site
329726004489	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726004490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726004491	active site
329726004492	phosphorylation site [posttranslational modification]
329726004493	intermolecular recognition site; other site
329726004494	dimerization interface [polypeptide binding]; other site
329726004495	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726004496	DNA binding residues [nucleotide binding]
329726004497	dimerization interface [polypeptide binding]; other site
329726004498	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
329726004499	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
329726004500	ResB-like family; Region: ResB; pfam05140
329726004501	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
329726004502	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
329726004503	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
329726004504	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726004505	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726004506	Coenzyme A binding pocket [chemical binding]; other site
329726004507	S-layer homology domain; Region: SLH; pfam00395
329726004508	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
329726004509	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
329726004510	dimer interface [polypeptide binding]; other site
329726004511	[2Fe-2S] cluster binding site [ion binding]; other site
329726004512	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
329726004513	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
329726004514	Walker A/P-loop; other site
329726004515	ATP binding site [chemical binding]; other site
329726004516	Q-loop/lid; other site
329726004517	ABC transporter signature motif; other site
329726004518	Walker B; other site
329726004519	D-loop; other site
329726004520	H-loop/switch region; other site
329726004521	DevC protein; Region: devC; TIGR01185
329726004522	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
329726004523	FtsX-like permease family; Region: FtsX; pfam02687
329726004524	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
329726004525	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726004526	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004527	Dynamin family; Region: Dynamin_N; pfam00350
329726004528	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
329726004529	G1 box; other site
329726004530	GTP/Mg2+ binding site [chemical binding]; other site
329726004531	Switch I region; other site
329726004532	G2 box; other site
329726004533	Switch II region; other site
329726004534	G3 box; other site
329726004535	G4 box; other site
329726004536	G5 box; other site
329726004537	Domain of unknown function (DUF697); Region: DUF697; pfam05128
329726004538	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
329726004539	G1 box; other site
329726004540	GTP/Mg2+ binding site [chemical binding]; other site
329726004541	G2 box; other site
329726004542	Switch I region; other site
329726004543	Switch II region; other site
329726004544	G4 box; other site
329726004545	G5 box; other site
329726004546	Domain of unknown function (DUF697); Region: DUF697; pfam05128
329726004547	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
329726004548	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
329726004549	Sulfate transporter family; Region: Sulfate_transp; pfam00916
329726004550	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
329726004551	RNA polymerase sigma factor RpoD; Validated; Region: PRK07406
329726004552	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726004553	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726004554	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726004555	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726004556	DNA binding residues [nucleotide binding]
329726004557	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
329726004558	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
329726004559	metal-binding site [ion binding]
329726004560	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
329726004561	Soluble P-type ATPase [General function prediction only]; Region: COG4087
329726004562	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
329726004563	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
329726004564	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
329726004565	AAA domain; Region: AAA_33; pfam13671
329726004566	ATP-binding site [chemical binding]; other site
329726004567	Gluconate-6-phosphate binding site [chemical binding]; other site
329726004568	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726004569	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004570	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004571	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004572	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004573	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004574	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004575	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004576	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726004577	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004578	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004579	Predicted metalloprotease [General function prediction only]; Region: COG2321
329726004580	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
329726004581	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726004582	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726004583	phosphopeptide binding site; other site
329726004584	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
329726004585	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726004586	Walker A motif; other site
329726004587	ATP binding site [chemical binding]; other site
329726004588	Walker B motif; other site
329726004589	arginine finger; other site
329726004590	prephenate dehydratase; Provisional; Region: PRK11898
329726004591	Prephenate dehydratase; Region: PDT; pfam00800
329726004592	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
329726004593	putative L-Phe binding site [chemical binding]; other site
329726004594	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
329726004595	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726004596	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726004597	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726004598	metal binding site [ion binding]; metal-binding site
329726004599	active site
329726004600	I-site; other site
329726004601	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
329726004602	active site
329726004603	SAM binding site [chemical binding]; other site
329726004604	homodimer interface [polypeptide binding]; other site
329726004605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726004606	ABC-ATPase subunit interface; other site
329726004607	putative PBP binding loops; other site
329726004608	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726004609	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004610	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004611	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004612	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726004613	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726004614	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
329726004615	hypothetical protein; Validated; Region: PRK00110
329726004616	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
329726004617	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
329726004618	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
329726004619	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
329726004620	Walker A/P-loop; other site
329726004621	ATP binding site [chemical binding]; other site
329726004622	Q-loop/lid; other site
329726004623	ABC transporter signature motif; other site
329726004624	Walker B; other site
329726004625	D-loop; other site
329726004626	H-loop/switch region; other site
329726004627	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
329726004628	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
329726004629	FtsX-like permease family; Region: FtsX; pfam02687
329726004630	cyanoexosortase A; Region: cyanoexo_CrtA; TIGR03763
329726004631	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
329726004632	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726004633	active site
329726004634	ATP binding site [chemical binding]; other site
329726004635	substrate binding site [chemical binding]; other site
329726004636	activation loop (A-loop); other site
329726004637	C factor cell-cell signaling protein; Provisional; Region: PRK09009
329726004638	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
329726004639	NADP binding site [chemical binding]; other site
329726004640	homodimer interface [polypeptide binding]; other site
329726004641	active site
329726004642	Protein of unknown function (DUF3565); Region: DUF3565; pfam12088
329726004643	Domain of unknown function (DUF1971); Region: DUF1971; cl17717
329726004644	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
329726004645	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
329726004646	Haemolytic domain; Region: Haemolytic; cl00506
329726004647	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
329726004648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
329726004649	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
329726004650	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
329726004651	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
329726004652	NAD(P) binding site [chemical binding]; other site
329726004653	catalytic residues [active]
329726004654	acetolactate synthase; Reviewed; Region: PRK08322
329726004655	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
329726004656	PYR/PP interface [polypeptide binding]; other site
329726004657	dimer interface [polypeptide binding]; other site
329726004658	TPP binding site [chemical binding]; other site
329726004659	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
329726004660	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
329726004661	TPP-binding site [chemical binding]; other site
329726004662	dimer interface [polypeptide binding]; other site
329726004663	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
329726004664	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
329726004665	active site
329726004666	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
329726004667	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
329726004668	catalytic residues [active]
329726004669	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
329726004670	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726004671	GAF domain; Region: GAF; pfam01590
329726004672	Phytochrome region; Region: PHY; pfam00360
329726004673	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726004674	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726004675	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726004676	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726004677	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726004678	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726004679	dimer interface [polypeptide binding]; other site
329726004680	phosphorylation site [posttranslational modification]
329726004681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726004682	ATP binding site [chemical binding]; other site
329726004683	Mg2+ binding site [ion binding]; other site
329726004684	G-X-G motif; other site
329726004685	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726004686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726004687	active site
329726004688	phosphorylation site [posttranslational modification]
329726004689	intermolecular recognition site; other site
329726004690	dimerization interface [polypeptide binding]; other site
329726004691	Response regulator receiver domain; Region: Response_reg; pfam00072
329726004692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726004693	active site
329726004694	phosphorylation site [posttranslational modification]
329726004695	intermolecular recognition site; other site
329726004696	dimerization interface [polypeptide binding]; other site
329726004697	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
329726004698	putative binding surface; other site
329726004699	active site
329726004700	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726004701	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726004702	WHG domain; Region: WHG; pfam13305
329726004703	Domain of unknown function (DUF4345); Region: DUF4345; pfam14248
329726004704	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
329726004705	putative hydrophobic ligand binding site [chemical binding]; other site
329726004706	intracellular protease, PfpI family; Region: PfpI; TIGR01382
329726004707	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
329726004708	conserved cys residue [active]
329726004709	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
329726004710	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
329726004711	generic binding surface I; other site
329726004712	generic binding surface II; other site
329726004713	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
329726004714	putative catalytic site [active]
329726004715	putative metal binding site [ion binding]; other site
329726004716	putative phosphate binding site [ion binding]; other site
329726004717	Synechococcus sp. strain PCC 7942  PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162
329726004718	putative active site [active]
329726004719	putative metal binding site [ion binding]; other site
329726004720	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
329726004721	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726004722	Domain of unknown function (DUF897); Region: DUF897; pfam05982
329726004723	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
329726004724	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
329726004725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726004726	homodimer interface [polypeptide binding]; other site
329726004727	catalytic residue [active]
329726004728	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
329726004729	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
329726004730	active site residue [active]
329726004731	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
329726004732	active site residue [active]
329726004733	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
329726004734	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
329726004735	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
329726004736	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
329726004737	hypothetical protein; Provisional; Region: PRK13683
329726004738	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
329726004739	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
329726004740	Walker A/P-loop; other site
329726004741	ATP binding site [chemical binding]; other site
329726004742	Q-loop/lid; other site
329726004743	ABC transporter signature motif; other site
329726004744	Walker B; other site
329726004745	D-loop; other site
329726004746	H-loop/switch region; other site
329726004747	G8 domain; Region: G8; pfam10162
329726004748	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
329726004749	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726004750	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
329726004751	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
329726004752	Acyltransferase family; Region: Acyl_transf_3; pfam01757
329726004753	Trm112p-like protein; Region: Trm112p; cl01066
329726004754	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726004755	S-adenosylmethionine binding site [chemical binding]; other site
329726004756	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726004757	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726004758	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726004759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726004760	S-adenosylmethionine binding site [chemical binding]; other site
329726004761	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726004762	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726004763	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726004764	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726004765	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726004766	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726004767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726004768	O-Antigen ligase; Region: Wzy_C; cl04850
329726004769	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
329726004770	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
329726004771	putative ADP-binding pocket [chemical binding]; other site
329726004772	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726004773	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726004774	S-adenosylmethionine binding site [chemical binding]; other site
329726004775	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726004776	Methyltransferase domain; Region: Methyltransf_11; pfam08241
329726004777	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
329726004778	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
329726004779	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
329726004780	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
329726004781	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726004782	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726004783	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
329726004784	putative ADP-binding pocket [chemical binding]; other site
329726004785	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
329726004786	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726004787	Walker A/P-loop; other site
329726004788	ATP binding site [chemical binding]; other site
329726004789	Q-loop/lid; other site
329726004790	ABC transporter signature motif; other site
329726004791	Walker B; other site
329726004792	D-loop; other site
329726004793	H-loop/switch region; other site
329726004794	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
329726004795	active site
329726004796	dimer interface [polypeptide binding]; other site
329726004797	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
329726004798	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
329726004799	Ligand Binding Site [chemical binding]; other site
329726004800	Molecular Tunnel; other site
329726004801	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
329726004802	Cupin superfamily protein; Region: Cupin_4; pfam08007
329726004803	Cupin-like domain; Region: Cupin_8; pfam13621
329726004804	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
329726004805	active site
329726004806	metal-binding site [ion binding]
329726004807	nucleotide-binding site [chemical binding]; other site
329726004808	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
329726004809	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
329726004810	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
329726004811	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
329726004812	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
329726004813	metal binding site [ion binding]; metal-binding site
329726004814	dimer interface [polypeptide binding]; other site
329726004815	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
329726004816	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726004817	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726004818	S-adenosylmethionine binding site [chemical binding]; other site
329726004819	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
329726004820	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
329726004821	ligand binding site; other site
329726004822	oligomer interface; other site
329726004823	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
329726004824	dimer interface [polypeptide binding]; other site
329726004825	N-terminal domain interface [polypeptide binding]; other site
329726004826	sulfate 1 binding site; other site
329726004827	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
329726004828	Phosphate acyltransferases; Region: PlsC; smart00563
329726004829	putative acyl-acceptor binding pocket; other site
329726004830	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
329726004831	RibD C-terminal domain; Region: RibD_C; cl17279
329726004832	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
329726004833	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726004834	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
329726004835	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
329726004836	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
329726004837	dimer interface [polypeptide binding]; other site
329726004838	active site
329726004839	glycine-pyridoxal phosphate binding site [chemical binding]; other site
329726004840	folate binding site [chemical binding]; other site
329726004841	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
329726004842	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
329726004843	Mg++ binding site [ion binding]; other site
329726004844	putative catalytic motif [active]
329726004845	substrate binding site [chemical binding]; other site
329726004846	competence damage-inducible protein A; Provisional; Region: PRK00549
329726004847	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
329726004848	putative MPT binding site; other site
329726004849	Competence-damaged protein; Region: CinA; pfam02464
329726004850	Dehydroquinase class II; Region: DHquinase_II; pfam01220
329726004851	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
329726004852	trimer interface [polypeptide binding]; other site
329726004853	active site
329726004854	dimer interface [polypeptide binding]; other site
329726004855	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
329726004856	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
329726004857	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
329726004858	ABC transporter; Region: ABC_tran_2; pfam12848
329726004859	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
329726004860	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726004861	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726004862	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726004863	binding surface
329726004864	TPR repeat; Region: TPR_11; pfam13414
329726004865	TPR motif; other site
329726004866	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726004867	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726004868	binding surface
329726004869	TPR motif; other site
329726004870	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726004871	binding surface
329726004872	TPR motif; other site
329726004873	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
329726004874	Clp protease ATP binding subunit; Region: clpC; CHL00095
329726004875	Clp amino terminal domain; Region: Clp_N; pfam02861
329726004876	Clp amino terminal domain; Region: Clp_N; pfam02861
329726004877	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726004878	Walker A motif; other site
329726004879	ATP binding site [chemical binding]; other site
329726004880	Walker B motif; other site
329726004881	arginine finger; other site
329726004882	UvrB/uvrC motif; Region: UVR; pfam02151
329726004883	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726004884	Walker A motif; other site
329726004885	ATP binding site [chemical binding]; other site
329726004886	Walker B motif; other site
329726004887	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
329726004888	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
329726004889	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
329726004890	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
329726004891	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
329726004892	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
329726004893	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
329726004894	Ligand Binding Site [chemical binding]; other site
329726004895	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
329726004896	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
329726004897	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
329726004898	thiamine phosphate binding site [chemical binding]; other site
329726004899	active site
329726004900	pyrophosphate binding site [ion binding]; other site
329726004901	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
329726004902	thiS-thiF/thiG interaction site; other site
329726004903	ferrochelatase; Reviewed; Region: hemH; PRK00035
329726004904	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
329726004905	active site
329726004906	C-terminal domain interface [polypeptide binding]; other site
329726004907	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
329726004908	active site
329726004909	N-terminal domain interface [polypeptide binding]; other site
329726004910	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726004911	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726004912	active site
329726004913	phosphorylation site [posttranslational modification]
329726004914	intermolecular recognition site; other site
329726004915	dimerization interface [polypeptide binding]; other site
329726004916	Response regulator receiver domain; Region: Response_reg; pfam00072
329726004917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726004918	active site
329726004919	phosphorylation site [posttranslational modification]
329726004920	intermolecular recognition site; other site
329726004921	dimerization interface [polypeptide binding]; other site
329726004922	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
329726004923	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
329726004924	active site
329726004925	ATP binding site [chemical binding]; other site
329726004926	substrate binding site [chemical binding]; other site
329726004927	activation loop (A-loop); other site
329726004928	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
329726004929	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
329726004930	iron-sulfur cluster [ion binding]; other site
329726004931	[2Fe-2S] cluster binding site [ion binding]; other site
329726004932	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
329726004933	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
329726004934	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726004935	putative active site [active]
329726004936	heme pocket [chemical binding]; other site
329726004937	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726004938	dimer interface [polypeptide binding]; other site
329726004939	phosphorylation site [posttranslational modification]
329726004940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726004941	ATP binding site [chemical binding]; other site
329726004942	Mg2+ binding site [ion binding]; other site
329726004943	G-X-G motif; other site
329726004944	Response regulator receiver domain; Region: Response_reg; pfam00072
329726004945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726004946	active site
329726004947	phosphorylation site [posttranslational modification]
329726004948	intermolecular recognition site; other site
329726004949	dimerization interface [polypeptide binding]; other site
329726004950	Response regulator receiver domain; Region: Response_reg; pfam00072
329726004951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726004952	active site
329726004953	phosphorylation site [posttranslational modification]
329726004954	intermolecular recognition site; other site
329726004955	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
329726004956	putative hydrophobic ligand binding site [chemical binding]; other site
329726004957	protein interface [polypeptide binding]; other site
329726004958	gate; other site
329726004959	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
329726004960	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
329726004961	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726004962	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726004963	dimer interface [polypeptide binding]; other site
329726004964	phosphorylation site [posttranslational modification]
329726004965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726004966	ATP binding site [chemical binding]; other site
329726004967	Mg2+ binding site [ion binding]; other site
329726004968	G-X-G motif; other site
329726004969	CAAX protease self-immunity; Region: Abi; cl00558
329726004970	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722
329726004971	phosphate binding site [ion binding]; other site
329726004972	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
329726004973	catalytic center binding site [active]
329726004974	ATP binding site [chemical binding]; other site
329726004975	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
329726004976	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
329726004977	dimer interface [polypeptide binding]; other site
329726004978	ADP-ribose binding site [chemical binding]; other site
329726004979	active site
329726004980	nudix motif; other site
329726004981	metal binding site [ion binding]; metal-binding site
329726004982	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
329726004983	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
329726004984	Substrate binding site [chemical binding]; other site
329726004985	Leucine rich repeat; Region: LRR_8; pfam13855
329726004986	Leucine rich repeat; Region: LRR_8; pfam13855
329726004987	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
329726004988	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
329726004989	G1 box; other site
329726004990	GTP/Mg2+ binding site [chemical binding]; other site
329726004991	G2 box; other site
329726004992	Switch I region; other site
329726004993	G3 box; other site
329726004994	Switch II region; other site
329726004995	G4 box; other site
329726004996	G5 box; other site
329726004997	TIR domain; Region: TIR_2; pfam13676
329726004998	Predicted membrane protein [Function unknown]; Region: COG3686
329726004999	Radical SAM superfamily; Region: Radical_SAM; pfam04055
329726005000	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726005001	FeS/SAM binding site; other site
329726005002	Predicted GTPase [General function prediction only]; Region: COG3596
329726005003	YfjP GTPase; Region: YfjP; cd11383
329726005004	G1 box; other site
329726005005	GTP/Mg2+ binding site [chemical binding]; other site
329726005006	Switch I region; other site
329726005007	G2 box; other site
329726005008	Switch II region; other site
329726005009	G3 box; other site
329726005010	G4 box; other site
329726005011	Protein of unknown function (DUF760); Region: DUF760; pfam05542
329726005012	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
329726005013	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
329726005014	active site
329726005015	catalytic tetrad [active]
329726005016	Bifunctional nuclease; Region: DNase-RNase; pfam02577
329726005017	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
329726005018	Lumazine binding domain; Region: Lum_binding; pfam00677
329726005019	Lumazine binding domain; Region: Lum_binding; pfam00677
329726005020	VanZ like family; Region: VanZ; cl01971
329726005021	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
329726005022	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
329726005023	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
329726005024	DNA binding site [nucleotide binding]
329726005025	active site
329726005026	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
329726005027	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
329726005028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726005029	dimer interface [polypeptide binding]; other site
329726005030	conserved gate region; other site
329726005031	putative PBP binding loops; other site
329726005032	ABC-ATPase subunit interface; other site
329726005033	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
329726005034	Predicted transcriptional regulator [Transcription]; Region: COG3682
329726005035	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
329726005036	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
329726005037	ADP-ribose binding site [chemical binding]; other site
329726005038	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
329726005039	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726005040	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726005041	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726005042	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
329726005043	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726005044	Domain of unknown function DUF29; Region: DUF29; pfam01724
329726005045	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
329726005046	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726005047	motif II; other site
329726005048	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726005049	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726005050	S-adenosylmethionine binding site [chemical binding]; other site
329726005051	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
329726005052	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
329726005053	putative active site [active]
329726005054	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
329726005055	putative active site [active]
329726005056	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
329726005057	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
329726005058	active site
329726005059	TDP-binding site; other site
329726005060	acceptor substrate-binding pocket; other site
329726005061	homodimer interface [polypeptide binding]; other site
329726005062	Predicted acetyltransferase [General function prediction only]; Region: COG5628
329726005063	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
329726005064	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
329726005065	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
329726005066	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
329726005067	putative catalytic cysteine [active]
329726005068	PRC-barrel domain; Region: PRC; pfam05239
329726005069	PRC-barrel domain; Region: PRC; pfam05239
329726005070	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726005071	putative active site [active]
329726005072	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
329726005073	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
329726005074	putative active site [active]
329726005075	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
329726005076	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
329726005077	active site
329726005078	catalytic tetrad [active]
329726005079	Conserved TM helix; Region: TM_helix; pfam05552
329726005080	Conserved TM helix; Region: TM_helix; pfam05552
329726005081	Conserved TM helix; Region: TM_helix; pfam05552
329726005082	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
329726005083	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
329726005084	putative dimer interface [polypeptide binding]; other site
329726005085	putative anticodon binding site; other site
329726005086	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
329726005087	homodimer interface [polypeptide binding]; other site
329726005088	motif 1; other site
329726005089	motif 2; other site
329726005090	active site
329726005091	motif 3; other site
329726005092	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
329726005093	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
329726005094	SLBB domain; Region: SLBB; pfam10531
329726005095	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
329726005096	SLBB domain; Region: SLBB; pfam10531
329726005097	glycogen synthase; Provisional; Region: glgA; PRK00654
329726005098	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
329726005099	ADP-binding pocket [chemical binding]; other site
329726005100	homodimer interface [polypeptide binding]; other site
329726005101	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
329726005102	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
329726005103	Photosystem II reaction centre M protein (PsbM); Region: PsbM; cl11459
329726005104	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726005105	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726005106	catalytic loop [active]
329726005107	iron binding site [ion binding]; other site
329726005108	photosystem II 47 kDa protein; Region: psbB; CHL00062
329726005109	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
329726005110	RimM N-terminal domain; Region: RimM; pfam01782
329726005111	PRC-barrel domain; Region: PRC; pfam05239
329726005112	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
329726005113	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
329726005114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726005115	homodimer interface [polypeptide binding]; other site
329726005116	catalytic residue [active]
329726005117	Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112
329726005118	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
329726005119	active site
329726005120	ATP binding site [chemical binding]; other site
329726005121	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726005122	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726005123	Coenzyme A binding pocket [chemical binding]; other site
329726005124	amidase; Provisional; Region: PRK09201
329726005125	Amidase; Region: Amidase; cl11426
329726005126	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
329726005127	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
329726005128	Leucine rich repeat; Region: LRR_8; pfam13855
329726005129	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
329726005130	Leucine rich repeat; Region: LRR_8; pfam13855
329726005131	Leucine-rich repeats; other site
329726005132	Substrate binding site [chemical binding]; other site
329726005133	Leucine rich repeat; Region: LRR_8; pfam13855
329726005134	Leucine rich repeat; Region: LRR_8; pfam13855
329726005135	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
329726005136	Leucine-rich repeats; other site
329726005137	Substrate binding site [chemical binding]; other site
329726005138	Leucine rich repeat; Region: LRR_8; pfam13855
329726005139	Leucine rich repeat; Region: LRR_8; pfam13855
329726005140	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
329726005141	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
329726005142	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
329726005143	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
329726005144	metal ion-dependent adhesion site (MIDAS); other site
329726005145	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
329726005146	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
329726005147	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
329726005148	active site
329726005149	interdomain interaction site; other site
329726005150	putative metal-binding site [ion binding]; other site
329726005151	nucleotide binding site [chemical binding]; other site
329726005152	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
329726005153	domain I; other site
329726005154	phosphate binding site [ion binding]; other site
329726005155	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
329726005156	domain II; other site
329726005157	domain III; other site
329726005158	nucleotide binding site [chemical binding]; other site
329726005159	DNA binding groove [nucleotide binding]
329726005160	catalytic site [active]
329726005161	domain IV; other site
329726005162	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
329726005163	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
329726005164	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
329726005165	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
329726005166	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
329726005167	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
329726005168	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
329726005169	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
329726005170	dimerization interface [polypeptide binding]; other site
329726005171	FAD binding pocket [chemical binding]; other site
329726005172	FAD binding motif [chemical binding]; other site
329726005173	catalytic residues [active]
329726005174	NAD binding pocket [chemical binding]; other site
329726005175	phosphate binding motif [ion binding]; other site
329726005176	beta-alpha-beta structure motif; other site
329726005177	geranylgeranyl reductase; Region: ChlP; TIGR02028
329726005178	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
329726005179	hypothetical protein; Provisional; Region: PRK07236
329726005180	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
329726005181	oligomerization interface [polypeptide binding]; other site
329726005182	active site
329726005183	metal binding site [ion binding]; metal-binding site
329726005184	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
329726005185	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
329726005186	putative active site [active]
329726005187	oxyanion strand; other site
329726005188	catalytic triad [active]
329726005189	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
329726005190	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726005191	S-adenosylmethionine binding site [chemical binding]; other site
329726005192	cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665
329726005193	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
329726005194	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
329726005195	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
329726005196	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
329726005197	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
329726005198	Zn binding site [ion binding]; other site
329726005199	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
329726005200	protein binding site [polypeptide binding]; other site
329726005201	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
329726005202	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
329726005203	nucleotide binding site [chemical binding]; other site
329726005204	putative NEF/HSP70 interaction site [polypeptide binding]; other site
329726005205	SBD interface [polypeptide binding]; other site
329726005206	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
329726005207	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726005208	NAD(P) binding site [chemical binding]; other site
329726005209	active site
329726005210	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
329726005211	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
329726005212	Mg++ binding site [ion binding]; other site
329726005213	putative catalytic motif [active]
329726005214	putative substrate binding site [chemical binding]; other site
329726005215	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
329726005216	homoserine dehydrogenase; Provisional; Region: PRK06349
329726005217	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
329726005218	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
329726005219	Domain of unknown function (DUF4291); Region: DUF4291; pfam14124
329726005220	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
329726005221	Sel1 repeat; Region: Sel1; cl02723
329726005222	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
329726005223	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
329726005224	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726005225	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726005226	Coenzyme A binding pocket [chemical binding]; other site
329726005227	AAA domain; Region: AAA_17; pfam13207
329726005228	seryl-tRNA synthetase; Provisional; Region: PRK05431
329726005229	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
329726005230	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
329726005231	dimer interface [polypeptide binding]; other site
329726005232	active site
329726005233	motif 1; other site
329726005234	motif 2; other site
329726005235	motif 3; other site
329726005236	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
329726005237	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
329726005238	tandem repeat interface [polypeptide binding]; other site
329726005239	oligomer interface [polypeptide binding]; other site
329726005240	active site residues [active]
329726005241	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726005242	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726005243	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
329726005244	NADH(P)-binding; Region: NAD_binding_10; pfam13460
329726005245	NAD binding site [chemical binding]; other site
329726005246	substrate binding site [chemical binding]; other site
329726005247	putative active site [active]
329726005248	Predicted integral membrane protein [Function unknown]; Region: COG5500
329726005249	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
329726005250	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
329726005251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726005252	dimer interface [polypeptide binding]; other site
329726005253	conserved gate region; other site
329726005254	putative PBP binding loops; other site
329726005255	ABC-ATPase subunit interface; other site
329726005256	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
329726005257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726005258	dimer interface [polypeptide binding]; other site
329726005259	conserved gate region; other site
329726005260	putative PBP binding loops; other site
329726005261	ABC-ATPase subunit interface; other site
329726005262	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
329726005263	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
329726005264	Uncharacterized conserved protein [Function unknown]; Region: COG2968
329726005265	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
329726005266	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
329726005267	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
329726005268	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
329726005269	protein binding site [polypeptide binding]; other site
329726005270	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
329726005271	Domain interface; other site
329726005272	Peptide binding site; other site
329726005273	Active site tetrad [active]
329726005274	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
329726005275	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
329726005276	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
329726005277	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
329726005278	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
329726005279	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
329726005280	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726005281	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
329726005282	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
329726005283	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
329726005284	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
329726005285	Transposase; Region: HTH_Tnp_IS630; pfam01710
329726005286	Helix-turn-helix domain; Region: HTH_28; pfam13518
329726005287	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726005288	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726005289	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726005290	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726005291	Homeodomain-like domain; Region: HTH_23; pfam13384
329726005292	Winged helix-turn helix; Region: HTH_29; pfam13551
329726005293	Homeodomain-like domain; Region: HTH_32; pfam13565
329726005294	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726005295	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726005296	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726005297	non-specific DNA binding site [nucleotide binding]; other site
329726005298	salt bridge; other site
329726005299	sequence-specific DNA binding site [nucleotide binding]; other site
329726005300	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912
329726005301	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726005302	putative active site [active]
329726005303	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
329726005304	4-alpha-glucanotransferase; Provisional; Region: PRK14508
329726005305	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
329726005306	hydroxyglutarate oxidase; Provisional; Region: PRK11728
329726005307	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
329726005308	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
329726005309	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
329726005310	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
329726005311	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
329726005312	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726005313	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726005314	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726005315	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726005316	DNA binding residues [nucleotide binding]
329726005317	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726005318	metal binding site 2 [ion binding]; metal-binding site
329726005319	putative DNA binding helix; other site
329726005320	metal binding site 1 [ion binding]; metal-binding site
329726005321	dimer interface [polypeptide binding]; other site
329726005322	structural Zn2+ binding site [ion binding]; other site
329726005323	Protein of unknown function, DUF479; Region: DUF479; cl01203
329726005324	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
329726005325	high affinity sulphate transporter 1; Region: sulP; TIGR00815
329726005326	Sulfate transporter family; Region: Sulfate_transp; pfam00916
329726005327	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
329726005328	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
329726005329	active site
329726005330	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
329726005331	homodimer interface [polypeptide binding]; other site
329726005332	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
329726005333	active site pocket [active]
329726005334	methionine sulfoxide reductase B; Provisional; Region: PRK00222
329726005335	SelR domain; Region: SelR; pfam01641
329726005336	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
329726005337	hydrolase, alpha/beta fold family protein; Region: PLN02824
329726005338	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
329726005339	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
329726005340	putative valine binding site [chemical binding]; other site
329726005341	dimer interface [polypeptide binding]; other site
329726005342	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
329726005343	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
329726005344	Predicted integral membrane protein [Function unknown]; Region: COG0762
329726005345	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
329726005346	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
329726005347	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
329726005348	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
329726005349	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
329726005350	23S rRNA binding site [nucleotide binding]; other site
329726005351	L21 binding site [polypeptide binding]; other site
329726005352	L13 binding site [polypeptide binding]; other site
329726005353	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
329726005354	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
329726005355	Clp amino terminal domain; Region: Clp_N; pfam02861
329726005356	Clp amino terminal domain; Region: Clp_N; pfam02861
329726005357	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726005358	Walker A motif; other site
329726005359	ATP binding site [chemical binding]; other site
329726005360	Walker B motif; other site
329726005361	arginine finger; other site
329726005362	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726005363	Walker A motif; other site
329726005364	ATP binding site [chemical binding]; other site
329726005365	Walker B motif; other site
329726005366	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
329726005367	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
329726005368	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
329726005369	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
329726005370	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
329726005371	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
329726005372	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
329726005373	cell division protein; Validated; Region: ftsH; CHL00176
329726005374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726005375	Walker A motif; other site
329726005376	ATP binding site [chemical binding]; other site
329726005377	Walker B motif; other site
329726005378	arginine finger; other site
329726005379	Peptidase family M41; Region: Peptidase_M41; pfam01434
329726005380	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
329726005381	nitrilase; Region: PLN02798
329726005382	putative active site [active]
329726005383	catalytic triad [active]
329726005384	dimer interface [polypeptide binding]; other site
329726005385	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726005386	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
329726005387	AMIN domain; Region: AMIN; pfam11741
329726005388	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
329726005389	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
329726005390	active site
329726005391	metal binding site [ion binding]; metal-binding site
329726005392	malate dehydrogenase; Reviewed; Region: PRK06223
329726005393	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
329726005394	NAD(P) binding site [chemical binding]; other site
329726005395	dimer interface [polypeptide binding]; other site
329726005396	tetramer (dimer of dimers) interface [polypeptide binding]; other site
329726005397	substrate binding site [chemical binding]; other site
329726005398	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
329726005399	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
329726005400	Cupin domain; Region: Cupin_2; cl17218
329726005401	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
329726005402	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
329726005403	Competence protein; Region: Competence; pfam03772
329726005404	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
329726005405	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
329726005406	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726005407	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
329726005408	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
329726005409	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
329726005410	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
329726005411	acyl-activating enzyme (AAE) consensus motif; other site
329726005412	acyl-activating enzyme (AAE) consensus motif; other site
329726005413	putative AMP binding site [chemical binding]; other site
329726005414	putative active site [active]
329726005415	putative CoA binding site [chemical binding]; other site
329726005416	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
329726005417	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
329726005418	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
329726005419	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
329726005420	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
329726005421	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
329726005422	substrate binding site [chemical binding]; other site
329726005423	oxyanion hole (OAH) forming residues; other site
329726005424	trimer interface [polypeptide binding]; other site
329726005425	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
329726005426	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
329726005427	dimer interface [polypeptide binding]; other site
329726005428	active site
329726005429	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
329726005430	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
329726005431	active site
329726005432	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
329726005433	DNA polymerase I; Provisional; Region: PRK05755
329726005434	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
329726005435	active site
329726005436	metal binding site 1 [ion binding]; metal-binding site
329726005437	putative 5' ssDNA interaction site; other site
329726005438	metal binding site 3; metal-binding site
329726005439	metal binding site 2 [ion binding]; metal-binding site
329726005440	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
329726005441	putative DNA binding site [nucleotide binding]; other site
329726005442	putative metal binding site [ion binding]; other site
329726005443	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
329726005444	active site
329726005445	catalytic site [active]
329726005446	substrate binding site [chemical binding]; other site
329726005447	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
329726005448	active site
329726005449	DNA binding site [nucleotide binding]
329726005450	catalytic site [active]
329726005451	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
329726005452	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
329726005453	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
329726005454	catalytic residue [active]
329726005455	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
329726005456	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
329726005457	catalytic core [active]
329726005458	citrate synthase; Provisional; Region: PRK14036
329726005459	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
329726005460	oxalacetate binding site [chemical binding]; other site
329726005461	citrylCoA binding site [chemical binding]; other site
329726005462	coenzyme A binding site [chemical binding]; other site
329726005463	catalytic triad [active]
329726005464	NADH dehydrogenase subunit 1; Region: ndhA; CHL00032
329726005465	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
329726005466	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
329726005467	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
329726005468	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
329726005469	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
329726005470	Rhomboid family; Region: Rhomboid; cl11446
329726005471	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
329726005472	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
329726005473	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
329726005474	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
329726005475	TIR domain; Region: TIR_2; pfam13676
329726005476	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726005477	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726005478	structural tetrad; other site
329726005479	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726005480	structural tetrad; other site
329726005481	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726005482	structural tetrad; other site
329726005483	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
329726005484	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
329726005485	Rab subfamily motif 1 (RabSF1); other site
329726005486	G1 box; other site
329726005487	GTP/Mg2+ binding site [chemical binding]; other site
329726005488	Rab subfamily motif 2 (RabSF2); other site
329726005489	Switch I region; other site
329726005490	G2 box; other site
329726005491	effector interaction site; other site
329726005492	GDI interaction site; other site
329726005493	Rab family motif 1 (RabF1); other site
329726005494	GEF interaction site [polypeptide binding]; other site
329726005495	Rab family motif 2 (RabF2); other site
329726005496	G3 box; other site
329726005497	Switch II region; other site
329726005498	Rab family motif 3 (RabF3); other site
329726005499	Rab family motif 4 (RabF4); other site
329726005500	Rab family motif 5 (RabF5); other site
329726005501	Rab subfamily motif 3 (RabSF3); other site
329726005502	G4 box; other site
329726005503	G5 box; other site
329726005504	Rab subfamily motif 4 (RabSF4); other site
329726005505	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
329726005506	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
329726005507	hypothetical protein; Provisional; Region: PRK07236
329726005508	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
329726005509	protein I interface; other site
329726005510	D2 interface; other site
329726005511	protein T interface; other site
329726005512	chlorophyll binding site; other site
329726005513	beta carotene binding site; other site
329726005514	pheophytin binding site; other site
329726005515	manganese-stabilizing polypeptide interface; other site
329726005516	CP43 interface; other site
329726005517	protein L interface; other site
329726005518	oxygen evolving complex binding site; other site
329726005519	bromide binding site; other site
329726005520	quinone binding site; other site
329726005521	Fe binding site [ion binding]; other site
329726005522	core light harvesting interface; other site
329726005523	cytochrome b559 alpha subunit interface; other site
329726005524	cytochrome c-550 interface; other site
329726005525	protein J interface; other site
329726005526	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
329726005527	nucleotide binding site/active site [active]
329726005528	HIT family signature motif; other site
329726005529	catalytic residue [active]
329726005530	Protein of unknown function (DUF561); Region: DUF561; pfam04481
329726005531	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
329726005532	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
329726005533	active site
329726005534	Substrate binding site; other site
329726005535	Mg++ binding site; other site
329726005536	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
329726005537	putative trimer interface [polypeptide binding]; other site
329726005538	putative CoA binding site [chemical binding]; other site
329726005539	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
329726005540	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
329726005541	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
329726005542	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
329726005543	dimer interface [polypeptide binding]; other site
329726005544	ssDNA binding site [nucleotide binding]; other site
329726005545	tetramer (dimer of dimers) interface [polypeptide binding]; other site
329726005546	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
329726005547	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
329726005548	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
329726005549	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
329726005550	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726005551	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726005552	S-adenosylmethionine binding site [chemical binding]; other site
329726005553	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
329726005554	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
329726005555	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726005556	dimerization interface [polypeptide binding]; other site
329726005557	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726005558	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726005559	phosphopeptide binding site; other site
329726005560	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726005561	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726005562	phosphopeptide binding site; other site
329726005563	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
329726005564	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
329726005565	Walker A/P-loop; other site
329726005566	ATP binding site [chemical binding]; other site
329726005567	Q-loop/lid; other site
329726005568	ABC transporter signature motif; other site
329726005569	Walker B; other site
329726005570	D-loop; other site
329726005571	H-loop/switch region; other site
329726005572	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
329726005573	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
329726005574	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726005575	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726005576	active site
329726005577	ATP binding site [chemical binding]; other site
329726005578	substrate binding site [chemical binding]; other site
329726005579	activation loop (A-loop); other site
329726005580	Domain of unknown function DUF21; Region: DUF21; pfam01595
329726005581	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
329726005582	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
329726005583	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726005584	putative PBP binding loops; other site
329726005585	dimer interface [polypeptide binding]; other site
329726005586	ABC-ATPase subunit interface; other site
329726005587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726005588	dimer interface [polypeptide binding]; other site
329726005589	conserved gate region; other site
329726005590	putative PBP binding loops; other site
329726005591	ABC-ATPase subunit interface; other site
329726005592	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
329726005593	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
329726005594	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
329726005595	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
329726005596	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
329726005597	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
329726005598	Domain of unknown function (DUF303); Region: DUF303; pfam03629
329726005599	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
329726005600	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
329726005601	substrate binding site; other site
329726005602	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
329726005603	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726005604	NAD(P) binding site [chemical binding]; other site
329726005605	active site
329726005606	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
329726005607	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
329726005608	extended (e) SDRs; Region: SDR_e; cd08946
329726005609	NAD(P) binding site [chemical binding]; other site
329726005610	active site
329726005611	substrate binding site [chemical binding]; other site
329726005612	Protein of unknown function (DUF563); Region: DUF563; pfam04577
329726005613	KpsF/GutQ family protein; Region: kpsF; TIGR00393
329726005614	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
329726005615	putative active site [active]
329726005616	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
329726005617	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
329726005618	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
329726005619	Ligand binding site; other site
329726005620	oligomer interface; other site
329726005621	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
329726005622	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
329726005623	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
329726005624	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726005625	active site
329726005626	motif I; other site
329726005627	motif II; other site
329726005628	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726005629	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726005630	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
329726005631	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726005632	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
329726005633	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
329726005634	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
329726005635	HEAT repeats; Region: HEAT_2; pfam13646
329726005636	TROVE domain; Region: TROVE; pfam05731
329726005637	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
329726005638	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726005639	Methyltransferase domain; Region: Methyltransf_12; pfam08242
329726005640	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726005641	Methyltransferase domain; Region: Methyltransf_24; pfam13578
329726005642	Transposase domain (DUF772); Region: DUF772; pfam05598
329726005643	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726005644	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
329726005645	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
329726005646	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
329726005647	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
329726005648	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726005649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726005650	active site
329726005651	phosphorylation site [posttranslational modification]
329726005652	intermolecular recognition site; other site
329726005653	dimerization interface [polypeptide binding]; other site
329726005654	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726005655	DNA binding residues [nucleotide binding]
329726005656	dimerization interface [polypeptide binding]; other site
329726005657	DEAD-like helicases superfamily; Region: DEXDc; smart00487
329726005658	AAA domain; Region: AAA_30; pfam13604
329726005659	Family description; Region: UvrD_C_2; pfam13538
329726005660	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726005661	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726005662	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726005663	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
329726005664	Ion transport protein; Region: Ion_trans; pfam00520
329726005665	Ion channel; Region: Ion_trans_2; pfam07885
329726005666	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
329726005667	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
329726005668	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
329726005669	Predicted amidohydrolase [General function prediction only]; Region: COG0388
329726005670	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
329726005671	putative active site [active]
329726005672	catalytic triad [active]
329726005673	putative dimer interface [polypeptide binding]; other site
329726005674	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
329726005675	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726005676	FeS/SAM binding site; other site
329726005677	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726005678	Coenzyme A binding pocket [chemical binding]; other site
329726005679	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
329726005680	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
329726005681	dimerization interface [polypeptide binding]; other site
329726005682	putative ATP binding site [chemical binding]; other site
329726005683	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
329726005684	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
329726005685	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
329726005686	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
329726005687	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
329726005688	putative active site [active]
329726005689	HsdM N-terminal domain; Region: HsdM_N; pfam12161
329726005690	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
329726005691	Methyltransferase domain; Region: Methyltransf_26; pfam13659
329726005692	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
329726005693	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
329726005694	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726005695	ATP binding site [chemical binding]; other site
329726005696	putative Mg++ binding site [ion binding]; other site
329726005697	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
329726005698	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726005699	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
329726005700	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726005701	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726005702	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726005703	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726005704	DNA binding residues [nucleotide binding]
329726005705	dimerization interface [polypeptide binding]; other site
329726005706	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726005707	putative active site [active]
329726005708	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726005709	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726005710	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
329726005711	classical (c) SDRs; Region: SDR_c; cd05233
329726005712	NAD(P) binding site [chemical binding]; other site
329726005713	active site
329726005714	Transcriptional activator [Transcription]; Region: ChrR; COG3806
329726005715	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
329726005716	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
329726005717	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
329726005718	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
329726005719	GSH binding site [chemical binding]; other site
329726005720	catalytic residues [active]
329726005721	putative S-transferase; Provisional; Region: PRK11752
329726005722	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
329726005723	C-terminal domain interface [polypeptide binding]; other site
329726005724	GSH binding site (G-site) [chemical binding]; other site
329726005725	dimer interface [polypeptide binding]; other site
329726005726	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
329726005727	dimer interface [polypeptide binding]; other site
329726005728	N-terminal domain interface [polypeptide binding]; other site
329726005729	active site
329726005730	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
329726005731	MAPEG family; Region: MAPEG; cl09190
329726005732	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
329726005733	putative hydrophobic ligand binding site [chemical binding]; other site
329726005734	protein interface [polypeptide binding]; other site
329726005735	gate; other site
329726005736	Transcriptional regulator [Transcription]; Region: LysR; COG0583
329726005737	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726005738	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
329726005739	dimerization interface [polypeptide binding]; other site
329726005740	MAPEG family; Region: MAPEG; cl09190
329726005741	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726005742	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
329726005743	active site
329726005744	metal binding site [ion binding]; metal-binding site
329726005745	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
329726005746	homodimer interface [polypeptide binding]; other site
329726005747	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726005748	catalytic residue [active]
329726005749	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
329726005750	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
329726005751	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
329726005752	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
329726005753	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
329726005754	active site
329726005755	catalytic residues [active]
329726005756	DNA binding site [nucleotide binding]
329726005757	Int/Topo IB signature motif; other site
329726005758	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
329726005759	polymerase nucleotide-binding site; other site
329726005760	DNA-binding residues [nucleotide binding]; DNA binding site
329726005761	nucleotide binding site [chemical binding]; other site
329726005762	primase nucleotide-binding site [nucleotide binding]; other site
329726005763	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
329726005764	Transposase IS200 like; Region: Y1_Tnp; cl00848
329726005765	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
329726005766	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
329726005767	ligand binding site; other site
329726005768	oligomer interface; other site
329726005769	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
329726005770	dimer interface [polypeptide binding]; other site
329726005771	N-terminal domain interface [polypeptide binding]; other site
329726005772	sulfate 1 binding site; other site
329726005773	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
329726005774	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
329726005775	putative active site [active]
329726005776	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
329726005777	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
329726005778	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
329726005779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726005780	Walker A motif; other site
329726005781	ATP binding site [chemical binding]; other site
329726005782	Walker B motif; other site
329726005783	arginine finger; other site
329726005784	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
329726005785	Alphavirus glycoprotein J; Region: Alpha_GJ; pfam03229
329726005786	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
329726005787	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
329726005788	active site
329726005789	Na/Ca binding site [ion binding]; other site
329726005790	catalytic site [active]
329726005791	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726005792	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726005793	active site
329726005794	ATP binding site [chemical binding]; other site
329726005795	substrate binding site [chemical binding]; other site
329726005796	activation loop (A-loop); other site
329726005797	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
329726005798	diiron binding motif [ion binding]; other site
329726005799	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
329726005800	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
329726005801	substrate-cofactor binding pocket; other site
329726005802	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726005803	catalytic residue [active]
329726005804	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
329726005805	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726005806	Coenzyme A binding pocket [chemical binding]; other site
329726005807	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726005808	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
329726005809	active site
329726005810	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
329726005811	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
329726005812	Walker A/P-loop; other site
329726005813	ATP binding site [chemical binding]; other site
329726005814	Q-loop/lid; other site
329726005815	ABC transporter signature motif; other site
329726005816	Walker B; other site
329726005817	D-loop; other site
329726005818	H-loop/switch region; other site
329726005819	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
329726005820	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
329726005821	Walker A/P-loop; other site
329726005822	ATP binding site [chemical binding]; other site
329726005823	Q-loop/lid; other site
329726005824	ABC transporter signature motif; other site
329726005825	Walker B; other site
329726005826	D-loop; other site
329726005827	H-loop/switch region; other site
329726005828	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
329726005829	Protein of unknown function (DUF98); Region: DUF98; pfam01947
329726005830	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
329726005831	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
329726005832	integral membrane protein MviN; Region: mviN; TIGR01695
329726005833	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
329726005834	Response regulator receiver domain; Region: Response_reg; pfam00072
329726005835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726005836	active site
329726005837	phosphorylation site [posttranslational modification]
329726005838	intermolecular recognition site; other site
329726005839	dimerization interface [polypeptide binding]; other site
329726005840	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726005841	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726005842	metal binding site [ion binding]; metal-binding site
329726005843	active site
329726005844	I-site; other site
329726005845	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726005846	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
329726005847	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
329726005848	putative NAD(P) binding site [chemical binding]; other site
329726005849	homodimer interface [polypeptide binding]; other site
329726005850	homotetramer interface [polypeptide binding]; other site
329726005851	active site
329726005852	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
329726005853	dimer interface [polypeptide binding]; other site
329726005854	substrate binding site [chemical binding]; other site
329726005855	metal binding sites [ion binding]; metal-binding site
329726005856	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
329726005857	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
329726005858	hinge; other site
329726005859	active site
329726005860	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
329726005861	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
329726005862	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
329726005863	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
329726005864	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
329726005865	Uncharacterized conserved protein [Function unknown]; Region: COG1432
329726005866	LabA_like proteins; Region: LabA; cd10911
329726005867	putative metal binding site [ion binding]; other site
329726005868	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
329726005869	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
329726005870	active site
329726005871	HIGH motif; other site
329726005872	KMSKS motif; other site
329726005873	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
329726005874	tRNA binding surface [nucleotide binding]; other site
329726005875	anticodon binding site; other site
329726005876	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
329726005877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
329726005878	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
329726005879	mce related protein; Region: MCE; pfam02470
329726005880	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
329726005881	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
329726005882	Walker A/P-loop; other site
329726005883	ATP binding site [chemical binding]; other site
329726005884	Q-loop/lid; other site
329726005885	ABC transporter signature motif; other site
329726005886	Walker B; other site
329726005887	D-loop; other site
329726005888	H-loop/switch region; other site
329726005889	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726005890	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726005891	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726005892	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726005893	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726005894	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726005895	HEAT repeats; Region: HEAT_2; pfam13646
329726005896	HEAT repeats; Region: HEAT_2; pfam13646
329726005897	prolyl-tRNA synthetase; Provisional; Region: PRK09194
329726005898	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
329726005899	dimer interface [polypeptide binding]; other site
329726005900	motif 1; other site
329726005901	active site
329726005902	motif 2; other site
329726005903	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
329726005904	putative deacylase active site [active]
329726005905	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
329726005906	active site
329726005907	motif 3; other site
329726005908	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
329726005909	anticodon binding site; other site
329726005910	Sporulation and spore germination; Region: Germane; pfam10646
329726005911	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
329726005912	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
329726005913	active site
329726005914	catalytic site [active]
329726005915	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
329726005916	calcium/proton exchanger (cax); Region: cax; TIGR00378
329726005917	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
329726005918	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
329726005919	S-layer homology domain; Region: SLH; pfam00395
329726005920	S-layer homology domain; Region: SLH; pfam00395
329726005921	MltA specific insert domain; Region: MltA; cl08398
329726005922	Clp protease; Region: CLP_protease; pfam00574
329726005923	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
329726005924	oligomer interface [polypeptide binding]; other site
329726005925	active site residues [active]
329726005926	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
329726005927	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
329726005928	oligomer interface [polypeptide binding]; other site
329726005929	active site residues [active]
329726005930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726005931	S-adenosylmethionine binding site [chemical binding]; other site
329726005932	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
329726005933	homotrimer interaction site [polypeptide binding]; other site
329726005934	putative active site [active]
329726005935	Chorismate mutase type II; Region: CM_2; cl00693
329726005936	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
329726005937	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
329726005938	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
329726005939	Walker A/P-loop; other site
329726005940	ATP binding site [chemical binding]; other site
329726005941	Q-loop/lid; other site
329726005942	ABC transporter signature motif; other site
329726005943	Walker B; other site
329726005944	D-loop; other site
329726005945	H-loop/switch region; other site
329726005946	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726005947	Coenzyme A binding pocket [chemical binding]; other site
329726005948	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
329726005949	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
329726005950	RNA binding surface [nucleotide binding]; other site
329726005951	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
329726005952	active site
329726005953	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
329726005954	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
329726005955	active site
329726005956	Repair protein; Region: Repair_PSII; pfam04536
329726005957	RNA polymerase sigma factor; Validated; Region: PRK05949
329726005958	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726005959	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726005960	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726005961	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726005962	DNA binding residues [nucleotide binding]
329726005963	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
329726005964	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
329726005965	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
329726005966	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
329726005967	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726005968	FeS/SAM binding site; other site
329726005969	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
329726005970	Ligand Binding Site [chemical binding]; other site
329726005971	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
329726005972	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
329726005973	active site
329726005974	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
329726005975	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
329726005976	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
329726005977	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
329726005978	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
329726005979	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
329726005980	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
329726005981	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
329726005982	bacterial Hfq-like; Region: Hfq; cd01716
329726005983	hexamer interface [polypeptide binding]; other site
329726005984	Sm1 motif; other site
329726005985	RNA binding site [nucleotide binding]; other site
329726005986	Sm2 motif; other site
329726005987	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
329726005988	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726005989	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726005990	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
329726005991	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
329726005992	DctM-like transporters; Region: DctM; pfam06808
329726005993	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
329726005994	hydrophobic ligand binding site; other site
329726005995	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
329726005996	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726005997	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
329726005998	tetramerization interface [polypeptide binding]; other site
329726005999	active site
329726006000	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
329726006001	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
329726006002	MoxR-like ATPases [General function prediction only]; Region: COG0714
329726006003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726006004	Walker A motif; other site
329726006005	ATP binding site [chemical binding]; other site
329726006006	Walker B motif; other site
329726006007	arginine finger; other site
329726006008	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
329726006009	Protein of unknown function DUF58; Region: DUF58; pfam01882
329726006010	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
329726006011	Tetratricopeptide repeat; Region: TPR_16; pfam13432
329726006012	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
329726006013	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
329726006014	NAD binding site [chemical binding]; other site
329726006015	putative substrate binding site 2 [chemical binding]; other site
329726006016	putative substrate binding site 1 [chemical binding]; other site
329726006017	active site
329726006018	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
329726006019	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
329726006020	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
329726006021	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
329726006022	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
329726006023	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726006024	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726006025	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
329726006026	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
329726006027	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
329726006028	DDE superfamily endonuclease; Region: DDE_4; pfam13359
329726006029	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
329726006030	Double zinc ribbon; Region: DZR; pfam12773
329726006031	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
329726006032	active site
329726006033	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
329726006034	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
329726006035	dimer interface [polypeptide binding]; other site
329726006036	active site
329726006037	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
329726006038	dimer interface [polypeptide binding]; other site
329726006039	active site
329726006040	Phycobilisome protein; Region: Phycobilisome; cl08227
329726006041	Sporulation related domain; Region: SPOR; pfam05036
329726006042	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726006043	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726006044	Homeodomain-like domain; Region: HTH_23; pfam13384
329726006045	Winged helix-turn helix; Region: HTH_29; pfam13551
329726006046	Homeodomain-like domain; Region: HTH_32; pfam13565
329726006047	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
329726006048	ABC1 family; Region: ABC1; pfam03109
329726006049	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
329726006050	active site
329726006051	ATP binding site [chemical binding]; other site
329726006052	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
329726006053	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
329726006054	Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867
329726006055	TSCPD domain; Region: TSCPD; pfam12637
329726006056	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
329726006057	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726006058	motif II; other site
329726006059	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
329726006060	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726006061	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726006062	phosphopeptide binding site; other site
329726006063	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726006064	GAF domain; Region: GAF; pfam01590
329726006065	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726006066	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726006067	dimer interface [polypeptide binding]; other site
329726006068	phosphorylation site [posttranslational modification]
329726006069	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726006070	ATP binding site [chemical binding]; other site
329726006071	Mg2+ binding site [ion binding]; other site
329726006072	G-X-G motif; other site
329726006073	Transcriptional regulators [Transcription]; Region: MarR; COG1846
329726006074	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
329726006075	putative DNA binding site [nucleotide binding]; other site
329726006076	putative Zn2+ binding site [ion binding]; other site
329726006077	MarR family; Region: MarR_2; cl17246
329726006078	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
329726006079	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
329726006080	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726006081	putative active site [active]
329726006082	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726006083	S-adenosylmethionine binding site [chemical binding]; other site
329726006084	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
329726006085	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
329726006086	NAD(P) binding site [chemical binding]; other site
329726006087	putative active site [active]
329726006088	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726006089	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726006090	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726006091	Homeodomain-like domain; Region: HTH_23; pfam13384
329726006092	Winged helix-turn helix; Region: HTH_29; pfam13551
329726006093	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
329726006094	active site
329726006095	catalytic site [active]
329726006096	substrate binding site [chemical binding]; other site
329726006097	DDE superfamily endonuclease; Region: DDE_5; cl17874
329726006098	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726006099	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
329726006100	Transposase; Region: HTH_Tnp_1; cl17663
329726006101	putative transposase OrfB; Reviewed; Region: PHA02517
329726006102	HTH-like domain; Region: HTH_21; pfam13276
329726006103	Integrase core domain; Region: rve; pfam00665
329726006104	Integrase core domain; Region: rve_3; pfam13683
329726006105	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726006106	Coenzyme A binding pocket [chemical binding]; other site
329726006107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726006108	S-adenosylmethionine binding site [chemical binding]; other site
329726006109	Domain of unknown function DUF87; Region: DUF87; pfam01935
329726006110	AAA-like domain; Region: AAA_10; pfam12846
329726006111	NurA domain; Region: NurA; cl09134
329726006112	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
329726006113	TPP-binding site [chemical binding]; other site
329726006114	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
329726006115	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
329726006116	PYR/PP interface [polypeptide binding]; other site
329726006117	dimer interface [polypeptide binding]; other site
329726006118	TPP binding site [chemical binding]; other site
329726006119	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
329726006120	adenylate kinase; Provisional; Region: adk; PRK02496
329726006121	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
329726006122	AMP-binding site [chemical binding]; other site
329726006123	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
329726006124	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
329726006125	tetramer (dimer of dimers) interface [polypeptide binding]; other site
329726006126	active site
329726006127	dimer interface [polypeptide binding]; other site
329726006128	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006129	binding surface
329726006130	TPR motif; other site
329726006131	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
329726006132	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
329726006133	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
329726006134	dimer interface [polypeptide binding]; other site
329726006135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726006136	catalytic residue [active]
329726006137	Predicted transcriptional regulator [Transcription]; Region: COG1959
329726006138	Transcriptional regulator; Region: Rrf2; pfam02082
329726006139	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
329726006140	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
329726006141	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
329726006142	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
329726006143	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
329726006144	aromatic arch; other site
329726006145	DCoH dimer interaction site [polypeptide binding]; other site
329726006146	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
329726006147	DCoH tetramer interaction site [polypeptide binding]; other site
329726006148	substrate binding site [chemical binding]; other site
329726006149	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
329726006150	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726006151	S-adenosylmethionine binding site [chemical binding]; other site
329726006152	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
329726006153	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006154	TPR repeat; Region: TPR_11; pfam13414
329726006155	binding surface
329726006156	TPR motif; other site
329726006157	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726006158	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
329726006159	DNA photolyase; Region: DNA_photolyase; pfam00875
329726006160	Outer membrane efflux protein; Region: OEP; pfam02321
329726006161	Outer membrane efflux protein; Region: OEP; pfam02321
329726006162	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
329726006163	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
329726006164	S-layer homology domain; Region: SLH; pfam00395
329726006165	S-layer homology domain; Region: SLH; pfam00395
329726006166	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
329726006167	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
329726006168	Probable Catalytic site; other site
329726006169	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
329726006170	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
329726006171	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726006172	Walker A motif; other site
329726006173	ATP binding site [chemical binding]; other site
329726006174	Walker B motif; other site
329726006175	arginine finger; other site
329726006176	Peptidase family M41; Region: Peptidase_M41; pfam01434
329726006177	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
329726006178	DHH family; Region: DHH; pfam01368
329726006179	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
329726006180	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
329726006181	active site
329726006182	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
329726006183	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
329726006184	nucleotide binding site [chemical binding]; other site
329726006185	NEF interaction site [polypeptide binding]; other site
329726006186	SBD interface [polypeptide binding]; other site
329726006187	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
329726006188	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
329726006189	dimer interface [polypeptide binding]; other site
329726006190	substrate binding site [chemical binding]; other site
329726006191	ATP binding site [chemical binding]; other site
329726006192	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
329726006193	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
329726006194	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
329726006195	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
329726006196	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726006197	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726006198	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
329726006199	cyclase homology domain; Region: CHD; cd07302
329726006200	nucleotidyl binding site; other site
329726006201	metal binding site [ion binding]; metal-binding site
329726006202	dimer interface [polypeptide binding]; other site
329726006203	cyclase homology domain; Region: CHD; cd07302
329726006204	nucleotidyl binding site; other site
329726006205	metal binding site [ion binding]; metal-binding site
329726006206	dimer interface [polypeptide binding]; other site
329726006207	Predicted ATPase [General function prediction only]; Region: COG3899
329726006208	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
329726006209	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726006210	Coenzyme A binding pocket [chemical binding]; other site
329726006211	Uncharacterized conserved protein [Function unknown]; Region: COG1434
329726006212	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
329726006213	putative active site [active]
329726006214	large tegument protein UL36; Provisional; Region: PHA03247
329726006215	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
329726006216	photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200
329726006217	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
329726006218	Electron transfer DM13; Region: DM13; pfam10517
329726006219	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
329726006220	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726006221	ATP binding site [chemical binding]; other site
329726006222	putative Mg++ binding site [ion binding]; other site
329726006223	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
329726006224	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726006225	nucleotide binding region [chemical binding]; other site
329726006226	ATP-binding site [chemical binding]; other site
329726006227	tellurium resistance terB-like protein; Region: terB_like; cd07177
329726006228	metal binding site [ion binding]; metal-binding site
329726006229	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
329726006230	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
329726006231	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
329726006232	substrate binding site [chemical binding]; other site
329726006233	catalytic Zn binding site [ion binding]; other site
329726006234	NAD binding site [chemical binding]; other site
329726006235	structural Zn binding site [ion binding]; other site
329726006236	dimer interface [polypeptide binding]; other site
329726006237	FHA domain; Region: FHA; pfam00498
329726006238	phosphopeptide binding site; other site
329726006239	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726006240	phosphopeptide binding site; other site
329726006241	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726006242	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726006243	phosphopeptide binding site; other site
329726006244	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
329726006245	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
329726006246	Walker A/P-loop; other site
329726006247	ATP binding site [chemical binding]; other site
329726006248	Q-loop/lid; other site
329726006249	ABC transporter signature motif; other site
329726006250	Walker B; other site
329726006251	D-loop; other site
329726006252	H-loop/switch region; other site
329726006253	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
329726006254	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
329726006255	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
329726006256	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
329726006257	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
329726006258	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
329726006259	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
329726006260	Walker A motif; other site
329726006261	ATP binding site [chemical binding]; other site
329726006262	Walker B motif; other site
329726006263	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726006264	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
329726006265	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726006266	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726006267	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726006268	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006269	binding surface
329726006270	TPR motif; other site
329726006271	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726006272	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726006273	Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236
329726006274	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726006275	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726006276	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726006277	FHA domain; Region: FHA; pfam00498
329726006278	phosphopeptide binding site; other site
329726006279	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
329726006280	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
329726006281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
329726006282	Transposase; Region: HTH_Tnp_1; cl17663
329726006283	putative transposase OrfB; Reviewed; Region: PHA02517
329726006284	HTH-like domain; Region: HTH_21; pfam13276
329726006285	Integrase core domain; Region: rve; pfam00665
329726006286	Integrase core domain; Region: rve_3; pfam13683
329726006287	Ion channel; Region: Ion_trans_2; pfam07885
329726006288	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
329726006289	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726006290	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
329726006291	Protein export membrane protein; Region: SecD_SecF; cl14618
329726006292	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
329726006293	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
329726006294	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
329726006295	active site
329726006296	dinuclear metal binding site [ion binding]; other site
329726006297	dimerization interface [polypeptide binding]; other site
329726006298	Phosphopantetheine attachment site; Region: PP-binding; cl09936
329726006299	VanZ like family; Region: VanZ; cl01971
329726006300	CP12 domain; Region: CP12; pfam02672
329726006301	Phosphotransferase enzyme family; Region: APH; pfam01636
329726006302	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
329726006303	active site
329726006304	ATP binding site [chemical binding]; other site
329726006305	CP12 domain; Region: CP12; pfam02672
329726006306	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
329726006307	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726006308	putative ADP-binding pocket [chemical binding]; other site
329726006309	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
329726006310	dimer interface [polypeptide binding]; other site
329726006311	catalytic triad [active]
329726006312	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
329726006313	Predicted membrane protein [Function unknown]; Region: COG4094
329726006314	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
329726006315	catalytic residues [active]
329726006316	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
329726006317	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
329726006318	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
329726006319	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
329726006320	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
329726006321	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
329726006322	YcxB-like protein; Region: YcxB; pfam14317
329726006323	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
329726006324	MoxR-like ATPases [General function prediction only]; Region: COG0714
329726006325	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726006326	Walker A motif; other site
329726006327	ATP binding site [chemical binding]; other site
329726006328	Walker B motif; other site
329726006329	arginine finger; other site
329726006330	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
329726006331	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
329726006332	DNA binding site [nucleotide binding]
329726006333	catalytic residue [active]
329726006334	H2TH interface [polypeptide binding]; other site
329726006335	putative catalytic residues [active]
329726006336	turnover-facilitating residue; other site
329726006337	intercalation triad [nucleotide binding]; other site
329726006338	8OG recognition residue [nucleotide binding]; other site
329726006339	putative reading head residues; other site
329726006340	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
329726006341	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
329726006342	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
329726006343	adaptive-response sensory kinase; Validated; Region: PRK09303
329726006344	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
329726006345	tetramer interface [polypeptide binding]; other site
329726006346	dimer interface [polypeptide binding]; other site
329726006347	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
329726006348	dimer interface [polypeptide binding]; other site
329726006349	phosphorylation site [posttranslational modification]
329726006350	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726006351	ATP binding site [chemical binding]; other site
329726006352	Mg2+ binding site [ion binding]; other site
329726006353	G-X-G motif; other site
329726006354	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726006355	structural tetrad; other site
329726006356	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726006357	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726006358	structural tetrad; other site
329726006359	WD40 repeats; Region: WD40; smart00320
329726006360	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726006361	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726006362	active site
329726006363	ATP binding site [chemical binding]; other site
329726006364	substrate binding site [chemical binding]; other site
329726006365	activation loop (A-loop); other site
329726006366	TIR domain; Region: TIR_2; pfam13676
329726006367	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
329726006368	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
329726006369	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726006370	haemagglutination activity domain; Region: Haemagg_act; pfam05860
329726006371	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726006372	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
329726006373	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
329726006374	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
329726006375	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
329726006376	active site
329726006377	PHP Thumb interface [polypeptide binding]; other site
329726006378	metal binding site [ion binding]; metal-binding site
329726006379	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
329726006380	protein-splicing catalytic site; other site
329726006381	thioester formation/cholesterol transfer; other site
329726006382	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
329726006383	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
329726006384	Zn2+ binding site [ion binding]; other site
329726006385	Mg2+ binding site [ion binding]; other site
329726006386	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
329726006387	synthetase active site [active]
329726006388	NTP binding site [chemical binding]; other site
329726006389	metal binding site [ion binding]; metal-binding site
329726006390	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
329726006391	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
329726006392	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
329726006393	metal ion-dependent adhesion site (MIDAS); other site
329726006394	Protein phosphatase 2C; Region: PP2C_2; pfam13672
329726006395	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
329726006396	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
329726006397	substrate binding site [chemical binding]; other site
329726006398	activation loop (A-loop); other site
329726006399	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726006400	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726006401	structural tetrad; other site
329726006402	AMIN domain; Region: AMIN; pfam11741
329726006403	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
329726006404	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
329726006405	active site
329726006406	metal binding site [ion binding]; metal-binding site
329726006407	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
329726006408	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
329726006409	active site
329726006410	metal binding site [ion binding]; metal-binding site
329726006411	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
329726006412	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726006413	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
329726006414	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
329726006415	active site
329726006416	Substrate binding site; other site
329726006417	Mg++ binding site; other site
329726006418	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
329726006419	putative trimer interface [polypeptide binding]; other site
329726006420	putative CoA binding site [chemical binding]; other site
329726006421	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
329726006422	Catalytic site [active]
329726006423	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
329726006424	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
329726006425	active site
329726006426	DNA binding site [nucleotide binding]
329726006427	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
329726006428	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
329726006429	putative catalytic residues [active]
329726006430	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
329726006431	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
329726006432	active site
329726006433	catalytic tetrad [active]
329726006434	SnoaL-like domain; Region: SnoaL_2; pfam12680
329726006435	stage V sporulation protein K; Region: spore_V_K; TIGR02881
329726006436	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726006437	Walker A motif; other site
329726006438	ATP binding site [chemical binding]; other site
329726006439	Walker B motif; other site
329726006440	arginine finger; other site
329726006441	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
329726006442	Phospholipid methyltransferase; Region: PEMT; cl17370
329726006443	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
329726006444	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
329726006445	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
329726006446	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
329726006447	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
329726006448	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726006449	Predicted transcriptional regulators [Transcription]; Region: COG1695
329726006450	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
329726006451	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
329726006452	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726006453	Homeodomain-like domain; Region: HTH_23; pfam13384
329726006454	Winged helix-turn helix; Region: HTH_29; pfam13551
329726006455	Winged helix-turn helix; Region: HTH_33; pfam13592
329726006456	Ebola nucleoprotein; Region: Ebola_NP; pfam05505
329726006457	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726006458	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726006459	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726006460	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726006461	Predicted flavoprotein [General function prediction only]; Region: COG0431
329726006462	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
329726006463	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
329726006464	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
329726006465	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
329726006466	Double zinc ribbon; Region: DZR; pfam12773
329726006467	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
329726006468	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726006469	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726006470	phosphopeptide binding site; other site
329726006471	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
329726006472	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726006473	putative substrate translocation pore; other site
329726006474	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
329726006475	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
329726006476	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
329726006477	metal binding site [ion binding]; metal-binding site
329726006478	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
329726006479	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726006480	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726006481	phosphopeptide binding site; other site
329726006482	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726006483	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
329726006484	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
329726006485	catalytic residues [active]
329726006486	DNA primase; Validated; Region: dnaG; PRK05667
329726006487	CHC2 zinc finger; Region: zf-CHC2; pfam01807
329726006488	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
329726006489	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
329726006490	active site
329726006491	metal binding site [ion binding]; metal-binding site
329726006492	interdomain interaction site; other site
329726006493	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
329726006494	alpha-dioxygenase; Region: PLN02283
329726006495	Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818
329726006496	putative heme binding site [chemical binding]; other site
329726006497	putative active site [active]
329726006498	putative substrate binding site [chemical binding]; other site
329726006499	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
329726006500	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
329726006501	active site
329726006502	FMN binding site [chemical binding]; other site
329726006503	substrate binding site [chemical binding]; other site
329726006504	putative catalytic residue [active]
329726006505	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
329726006506	phosphate binding site [ion binding]; other site
329726006507	Cytochrome c; Region: Cytochrom_C; pfam00034
329726006508	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
329726006509	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
329726006510	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726006511	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726006512	DevC protein; Region: devC; TIGR01185
329726006513	FtsX-like permease family; Region: FtsX; pfam02687
329726006514	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
329726006515	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
329726006516	Walker A/P-loop; other site
329726006517	ATP binding site [chemical binding]; other site
329726006518	Q-loop/lid; other site
329726006519	ABC transporter signature motif; other site
329726006520	Walker B; other site
329726006521	D-loop; other site
329726006522	H-loop/switch region; other site
329726006523	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
329726006524	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
329726006525	Catalytic site [active]
329726006526	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
329726006527	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726006528	non-specific DNA binding site [nucleotide binding]; other site
329726006529	salt bridge; other site
329726006530	sequence-specific DNA binding site [nucleotide binding]; other site
329726006531	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006532	binding surface
329726006533	TPR motif; other site
329726006534	TPR repeat; Region: TPR_11; pfam13414
329726006535	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006536	TPR motif; other site
329726006537	binding surface
329726006538	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006539	TPR motif; other site
329726006540	binding surface
329726006541	TPR repeat; Region: TPR_11; pfam13414
329726006542	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
329726006543	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
329726006544	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726006545	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726006546	DNA binding residues [nucleotide binding]
329726006547	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
329726006548	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
329726006549	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
329726006550	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
329726006551	cofactor binding site; other site
329726006552	DNA binding site [nucleotide binding]
329726006553	substrate interaction site [chemical binding]; other site
329726006554	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
329726006555	GIY-YIG motif/motif A; other site
329726006556	active site
329726006557	catalytic site [active]
329726006558	metal binding site [ion binding]; metal-binding site
329726006559	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006560	binding surface
329726006561	TPR motif; other site
329726006562	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006563	binding surface
329726006564	TPR motif; other site
329726006565	Allene oxide synthase; Region: AOS; cd08151
329726006566	dimer interface [polypeptide binding]; other site
329726006567	heme binding pocket [chemical binding]; other site
329726006568	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726006569	Homeodomain-like domain; Region: HTH_23; pfam13384
329726006570	Winged helix-turn helix; Region: HTH_29; pfam13551
329726006571	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726006572	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726006573	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726006574	Transthyretin-like family; Region: DUF290; pfam01060
329726006575	Lipoxygenase; Region: Lipoxygenase; pfam00305
329726006576	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
329726006577	ATP-grasp domain; Region: ATP-grasp_4; cl17255
329726006578	Radical SAM superfamily; Region: Radical_SAM; pfam04055
329726006579	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726006580	FeS/SAM binding site; other site
329726006581	VanW like protein; Region: VanW; pfam04294
329726006582	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
329726006583	PemK-like protein; Region: PemK; pfam02452
329726006584	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
329726006585	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
329726006586	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
329726006587	hypothetical protein; Provisional; Region: PRK08317
329726006588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726006589	S-adenosylmethionine binding site [chemical binding]; other site
329726006590	GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080
329726006591	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
329726006592	putative C-terminal domain interface [polypeptide binding]; other site
329726006593	putative GSH binding site [chemical binding]; other site
329726006594	putative dimer interface [polypeptide binding]; other site
329726006595	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
329726006596	N-terminal domain interface [polypeptide binding]; other site
329726006597	dimer interface [polypeptide binding]; other site
329726006598	substrate binding pocket (H-site) [chemical binding]; other site
329726006599	HEAT repeats; Region: HEAT_2; pfam13646
329726006600	HEAT repeats; Region: HEAT_2; pfam13646
329726006601	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
329726006602	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
329726006603	dimerization interface [polypeptide binding]; other site
329726006604	ATP binding site [chemical binding]; other site
329726006605	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
329726006606	dimerization interface [polypeptide binding]; other site
329726006607	ATP binding site [chemical binding]; other site
329726006608	amidophosphoribosyltransferase; Provisional; Region: PRK07349
329726006609	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
329726006610	active site
329726006611	tetramer interface [polypeptide binding]; other site
329726006612	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
329726006613	active site
329726006614	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
329726006615	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
329726006616	GTP/Mg2+ binding site [chemical binding]; other site
329726006617	G4 box; other site
329726006618	G5 box; other site
329726006619	G1 box; other site
329726006620	Switch I region; other site
329726006621	G2 box; other site
329726006622	G3 box; other site
329726006623	Switch II region; other site
329726006624	tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133
329726006625	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
329726006626	HIGH motif; other site
329726006627	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
329726006628	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
329726006629	active site
329726006630	KMSKS motif; other site
329726006631	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
329726006632	tRNA binding surface [nucleotide binding]; other site
329726006633	anticodon binding site; other site
329726006634	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
329726006635	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
329726006636	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
329726006637	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
329726006638	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
329726006639	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
329726006640	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
329726006641	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
329726006642	catalytic motif [active]
329726006643	Catalytic residue [active]
329726006644	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
329726006645	catalytic motif [active]
329726006646	Catalytic residue [active]
329726006647	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
329726006648	amidase catalytic site [active]
329726006649	Zn binding residues [ion binding]; other site
329726006650	substrate binding site [chemical binding]; other site
329726006651	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
329726006652	Pantoate-beta-alanine ligase; Region: PanC; cd00560
329726006653	active site
329726006654	ATP-binding site [chemical binding]; other site
329726006655	pantoate-binding site; other site
329726006656	HXXH motif; other site
329726006657	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
329726006658	CMP-binding site; other site
329726006659	The sites determining sugar specificity; other site
329726006660	aspartate aminotransferase; Provisional; Region: PRK05764
329726006661	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
329726006662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726006663	homodimer interface [polypeptide binding]; other site
329726006664	catalytic residue [active]
329726006665	AAA domain; Region: AAA_26; pfam13500
329726006666	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
329726006667	Predicted membrane protein [Function unknown]; Region: COG3431
329726006668	photosystem II protein J; Region: psbJ; CHL00108
329726006669	PsbL protein; Region: PsbL; cl03581
329726006670	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
329726006671	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
329726006672	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
329726006673	Ycf48-like protein; Provisional; Region: PRK13684
329726006674	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
329726006675	Rubredoxin; Region: Rubredoxin; pfam00301
329726006676	iron binding site [ion binding]; other site
329726006677	GTP-binding protein YchF; Reviewed; Region: PRK09601
329726006678	YchF GTPase; Region: YchF; cd01900
329726006679	G1 box; other site
329726006680	GTP/Mg2+ binding site [chemical binding]; other site
329726006681	Switch I region; other site
329726006682	G2 box; other site
329726006683	Switch II region; other site
329726006684	G3 box; other site
329726006685	G4 box; other site
329726006686	G5 box; other site
329726006687	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
329726006688	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
329726006689	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
329726006690	homodimer interface [polypeptide binding]; other site
329726006691	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726006692	catalytic residue [active]
329726006693	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
329726006694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726006695	S-adenosylmethionine binding site [chemical binding]; other site
329726006696	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
329726006697	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
329726006698	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
329726006699	putative active site [active]
329726006700	Double zinc ribbon; Region: DZR; pfam12773
329726006701	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
329726006702	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726006703	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726006704	phosphopeptide binding site; other site
329726006705	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726006706	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726006707	phosphopeptide binding site; other site
329726006708	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726006709	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726006710	active site
329726006711	ATP binding site [chemical binding]; other site
329726006712	substrate binding site [chemical binding]; other site
329726006713	activation loop (A-loop); other site
329726006714	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
329726006715	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
329726006716	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006717	Tetratricopeptide repeat; Region: TPR_16; pfam13432
329726006718	binding surface
329726006719	TPR motif; other site
329726006720	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006721	binding surface
329726006722	TPR motif; other site
329726006723	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006724	binding surface
329726006725	TPR motif; other site
329726006726	TPR repeat; Region: TPR_11; pfam13414
329726006727	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006728	binding surface
329726006729	TPR motif; other site
329726006730	TPR repeat; Region: TPR_11; pfam13414
329726006731	TPR repeat; Region: TPR_11; pfam13414
329726006732	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006733	binding surface
329726006734	TPR motif; other site
329726006735	elongation factor G; Reviewed; Region: PRK00007
329726006736	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
329726006737	G1 box; other site
329726006738	putative GEF interaction site [polypeptide binding]; other site
329726006739	GTP/Mg2+ binding site [chemical binding]; other site
329726006740	Switch I region; other site
329726006741	G2 box; other site
329726006742	G3 box; other site
329726006743	Switch II region; other site
329726006744	G4 box; other site
329726006745	G5 box; other site
329726006746	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
329726006747	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
329726006748	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
329726006749	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726006750	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726006751	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726006752	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726006753	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726006754	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726006755	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726006756	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
329726006757	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
329726006758	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
329726006759	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
329726006760	TrkA-N domain; Region: TrkA_N; pfam02254
329726006761	TrkA-C domain; Region: TrkA_C; pfam02080
329726006762	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
329726006763	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
329726006764	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
329726006765	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
329726006766	active site
329726006767	Riboflavin kinase; Region: Flavokinase; pfam01687
329726006768	MoxR-like ATPases [General function prediction only]; Region: COG0714
329726006769	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726006770	Walker A motif; other site
329726006771	ATP binding site [chemical binding]; other site
329726006772	Walker B motif; other site
329726006773	arginine finger; other site
329726006774	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
329726006775	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
329726006776	Glucose inhibited division protein A; Region: GIDA; pfam01134
329726006777	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
329726006778	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726006779	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726006780	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
329726006781	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
329726006782	putative C-terminal domain interface [polypeptide binding]; other site
329726006783	putative GSH binding site (G-site) [chemical binding]; other site
329726006784	putative dimer interface [polypeptide binding]; other site
329726006785	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
329726006786	putative N-terminal domain interface [polypeptide binding]; other site
329726006787	putative dimer interface [polypeptide binding]; other site
329726006788	putative substrate binding pocket (H-site) [chemical binding]; other site
329726006789	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
329726006790	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
329726006791	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
329726006792	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
329726006793	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
329726006794	catalytic residue [active]
329726006795	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
329726006796	active site residue [active]
329726006797	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
329726006798	active site residue [active]
329726006799	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
329726006800	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726006801	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
329726006802	substrate binding pocket [chemical binding]; other site
329726006803	dimerization interface [polypeptide binding]; other site
329726006804	Helix-turn-helix domain; Region: HTH_28; pfam13518
329726006805	Winged helix-turn helix; Region: HTH_29; pfam13551
329726006806	Homeodomain-like domain; Region: HTH_32; pfam13565
329726006807	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
329726006808	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726006809	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726006810	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
329726006811	NADP binding site [chemical binding]; other site
329726006812	NmrA-like family; Region: NmrA; pfam05368
329726006813	active site
329726006814	regulatory binding site [polypeptide binding]; other site
329726006815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726006816	NmrA-like family; Region: NmrA; pfam05368
329726006817	NAD(P) binding site [chemical binding]; other site
329726006818	active site
329726006819	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726006820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726006821	intermolecular recognition site; other site
329726006822	active site
329726006823	dimerization interface [polypeptide binding]; other site
329726006824	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
329726006825	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726006826	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726006827	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
329726006828	oxidoreductase; Provisional; Region: PRK06196
329726006829	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
329726006830	putative NAD(P) binding site [chemical binding]; other site
329726006831	active site
329726006832	SWIM zinc finger; Region: SWIM; pfam04434
329726006833	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726006834	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
329726006835	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
329726006836	tellurium resistance terB-like protein; Region: terB_like; cd07177
329726006837	metal binding site [ion binding]; metal-binding site
329726006838	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726006839	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726006840	NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180
329726006841	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
329726006842	dimer interface [polypeptide binding]; other site
329726006843	[2Fe-2S] cluster binding site [ion binding]; other site
329726006844	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726006845	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726006846	phosphopeptide binding site; other site
329726006847	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726006848	catalytic loop [active]
329726006849	iron binding site [ion binding]; other site
329726006850	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
329726006851	CAAX protease self-immunity; Region: Abi; pfam02517
329726006852	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
329726006853	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
329726006854	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
329726006855	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
329726006856	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
329726006857	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
329726006858	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
329726006859	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
329726006860	dimer interface [polypeptide binding]; other site
329726006861	decamer (pentamer of dimers) interface [polypeptide binding]; other site
329726006862	catalytic triad [active]
329726006863	peroxidatic and resolving cysteines [active]
329726006864	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
329726006865	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
329726006866	Ligand binding site; other site
329726006867	Putative Catalytic site; other site
329726006868	DXD motif; other site
329726006869	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726006870	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726006871	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726006872	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
329726006873	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726006874	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
329726006875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726006876	S-adenosylmethionine binding site [chemical binding]; other site
329726006877	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
329726006878	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726006879	NAD(P) binding site [chemical binding]; other site
329726006880	active site
329726006881	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
329726006882	Acid Phosphatase; Region: Acid_PPase; cl17256
329726006883	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
329726006884	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
329726006885	trimer interface [polypeptide binding]; other site
329726006886	active site
329726006887	substrate binding site [chemical binding]; other site
329726006888	CoA binding site [chemical binding]; other site
329726006889	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
329726006890	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
329726006891	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
329726006892	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726006893	Homeodomain-like domain; Region: HTH_23; pfam13384
329726006894	Winged helix-turn helix; Region: HTH_29; pfam13551
329726006895	Homeodomain-like domain; Region: HTH_32; pfam13565
329726006896	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726006897	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726006898	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
329726006899	putative active site [active]
329726006900	putative metal binding site [ion binding]; other site
329726006901	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
329726006902	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
329726006903	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
329726006904	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
329726006905	metal binding site [ion binding]; metal-binding site
329726006906	active site
329726006907	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726006908	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
329726006909	putative switch regulator; other site
329726006910	non-specific DNA interactions [nucleotide binding]; other site
329726006911	DNA binding site [nucleotide binding]
329726006912	sequence specific DNA binding site [nucleotide binding]; other site
329726006913	putative cAMP binding site [chemical binding]; other site
329726006914	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
329726006915	Dynamin family; Region: Dynamin_N; pfam00350
329726006916	G1 box; other site
329726006917	GTP/Mg2+ binding site [chemical binding]; other site
329726006918	G2 box; other site
329726006919	Switch I region; other site
329726006920	G3 box; other site
329726006921	Switch II region; other site
329726006922	G4 box; other site
329726006923	G5 box; other site
329726006924	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
329726006925	dimerization interface [polypeptide binding]; other site
329726006926	putative DNA binding site [nucleotide binding]; other site
329726006927	putative Zn2+ binding site [ion binding]; other site
329726006928	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
329726006929	putative hydrophobic ligand binding site [chemical binding]; other site
329726006930	NACHT domain; Region: NACHT; pfam05729
329726006931	GUN4-like; Region: GUN4; pfam05419
329726006932	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
329726006933	putative active site [active]
329726006934	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
329726006935	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726006936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726006937	active site
329726006938	phosphorylation site [posttranslational modification]
329726006939	intermolecular recognition site; other site
329726006940	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
329726006941	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726006942	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726006943	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726006944	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726006945	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726006946	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726006947	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
329726006948	Uncharacterized conserved protein [Function unknown]; Region: COG0393
329726006949	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726006950	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726006951	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726006952	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
329726006953	putative active site pocket [active]
329726006954	dimerization interface [polypeptide binding]; other site
329726006955	putative catalytic residue [active]
329726006956	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
329726006957	putative active site [active]
329726006958	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006959	TPR motif; other site
329726006960	binding surface
329726006961	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006962	binding surface
329726006963	TPR motif; other site
329726006964	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006965	binding surface
329726006966	TPR motif; other site
329726006967	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006968	TPR motif; other site
329726006969	binding surface
329726006970	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006971	binding surface
329726006972	TPR motif; other site
329726006973	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726006974	TPR motif; other site
329726006975	binding surface
329726006976	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
329726006977	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
329726006978	Protein of unknown function DUF58; Region: DUF58; pfam01882
329726006979	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
329726006980	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
329726006981	Cysteine-rich domain; Region: CCG; pfam02754
329726006982	Cysteine-rich domain; Region: CCG; pfam02754
329726006983	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
329726006984	FAD binding domain; Region: FAD_binding_4; pfam01565
329726006985	acetyl-CoA synthetase; Provisional; Region: PRK00174
329726006986	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
329726006987	active site
329726006988	CoA binding site [chemical binding]; other site
329726006989	acyl-activating enzyme (AAE) consensus motif; other site
329726006990	AMP binding site [chemical binding]; other site
329726006991	acetate binding site [chemical binding]; other site
329726006992	NACHT domain; Region: NACHT; pfam05729
329726006993	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
329726006994	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
329726006995	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726006996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726006997	S-adenosylmethionine binding site [chemical binding]; other site
329726006998	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
329726006999	Uncharacterized conserved protein [Function unknown]; Region: COG3339
329726007000	HD domain; Region: HD_4; pfam13328
329726007001	Cytochrome c; Region: Cytochrom_C; cl11414
329726007002	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
329726007003	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726007004	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726007005	Coenzyme A binding pocket [chemical binding]; other site
329726007006	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
329726007007	active site
329726007008	hydrophilic channel; other site
329726007009	dimerization interface [polypeptide binding]; other site
329726007010	catalytic residues [active]
329726007011	active site lid [active]
329726007012	TIR domain; Region: TIR_2; pfam13676
329726007013	CHAT domain; Region: CHAT; cl17868
329726007014	NB-ARC domain; Region: NB-ARC; pfam00931
329726007015	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726007016	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726007017	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007018	binding surface
329726007019	TPR motif; other site
329726007020	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726007021	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726007022	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007023	binding surface
329726007024	TPR motif; other site
329726007025	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726007026	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726007027	putative active site [active]
329726007028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007029	TPR motif; other site
329726007030	TPR repeat; Region: TPR_11; pfam13414
329726007031	binding surface
329726007032	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
329726007033	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
329726007034	Walker A/P-loop; other site
329726007035	ATP binding site [chemical binding]; other site
329726007036	Q-loop/lid; other site
329726007037	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
329726007038	ABC transporter signature motif; other site
329726007039	Walker B; other site
329726007040	D-loop; other site
329726007041	H-loop/switch region; other site
329726007042	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726007043	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726007044	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726007045	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726007046	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726007047	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726007048	Calcium binding; Region: Calci_bind_CcbP; pfam11535
329726007049	dephospho-CoA kinase; Region: TIGR00152
329726007050	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
329726007051	CoA-binding site [chemical binding]; other site
329726007052	ATP-binding [chemical binding]; other site
329726007053	Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020
329726007054	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
329726007055	HicB family; Region: HicB; pfam05534
329726007056	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
329726007057	trimer interface [polypeptide binding]; other site
329726007058	active site
329726007059	substrate binding site [chemical binding]; other site
329726007060	CoA binding site [chemical binding]; other site
329726007061	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
329726007062	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726007063	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
329726007064	PRC-barrel domain; Region: PRC; pfam05239
329726007065	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726007066	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726007067	S-adenosylmethionine binding site [chemical binding]; other site
329726007068	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726007069	D-loop; other site
329726007070	H-loop/switch region; other site
329726007071	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726007072	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
329726007073	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
329726007074	L-aspartate oxidase; Provisional; Region: PRK06175
329726007075	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
329726007076	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
329726007077	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726007078	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726007079	Protein of unknown function (DUF805); Region: DUF805; pfam05656
329726007080	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
329726007081	hydrolase, alpha/beta fold family protein; Region: PLN02824
329726007082	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726007083	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
329726007084	beta-galactosidase; Region: BGL; TIGR03356
329726007085	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
329726007086	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
329726007087	active site
329726007088	ATP binding site [chemical binding]; other site
329726007089	substrate binding site [chemical binding]; other site
329726007090	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
329726007091	active site
329726007092	ATP binding site [chemical binding]; other site
329726007093	substrate binding site [chemical binding]; other site
329726007094	activation loop (A-loop); other site
329726007095	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
329726007096	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
329726007097	DXD motif; other site
329726007098	PilZ domain; Region: PilZ; pfam07238
329726007099	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726007100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726007101	active site
329726007102	phosphorylation site [posttranslational modification]
329726007103	intermolecular recognition site; other site
329726007104	dimerization interface [polypeptide binding]; other site
329726007105	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
329726007106	putative active site [active]
329726007107	putative metal binding residues [ion binding]; other site
329726007108	signature motif; other site
329726007109	putative dimer interface [polypeptide binding]; other site
329726007110	putative phosphate binding site [ion binding]; other site
329726007111	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
329726007112	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
329726007113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726007114	dimer interface [polypeptide binding]; other site
329726007115	phosphorylation site [posttranslational modification]
329726007116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726007117	ATP binding site [chemical binding]; other site
329726007118	Mg2+ binding site [ion binding]; other site
329726007119	G-X-G motif; other site
329726007120	Predicted membrane protein [Function unknown]; Region: COG1981
329726007121	methionine sulfoxide reductase A; Provisional; Region: PRK00058
329726007122	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
329726007123	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
329726007124	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
329726007125	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726007126	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
329726007127	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726007128	Walker A/P-loop; other site
329726007129	ATP binding site [chemical binding]; other site
329726007130	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
329726007131	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
329726007132	ABC transporter signature motif; other site
329726007133	Walker B; other site
329726007134	D-loop; other site
329726007135	H-loop/switch region; other site
329726007136	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
329726007137	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
329726007138	DXD motif; other site
329726007139	AAA domain; Region: AAA_31; pfam13614
329726007140	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726007141	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
329726007142	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
329726007143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726007144	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
329726007145	NAD(P) binding site [chemical binding]; other site
329726007146	active site
329726007147	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
329726007148	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
329726007149	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
329726007150	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
329726007151	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
329726007152	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
329726007153	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
329726007154	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
329726007155	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726007156	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726007157	active site
329726007158	ATP binding site [chemical binding]; other site
329726007159	substrate binding site [chemical binding]; other site
329726007160	activation loop (A-loop); other site
329726007161	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726007162	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726007163	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726007164	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726007165	active site
329726007166	ATP binding site [chemical binding]; other site
329726007167	substrate binding site [chemical binding]; other site
329726007168	activation loop (A-loop); other site
329726007169	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726007170	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726007171	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
329726007172	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726007173	Walker A/P-loop; other site
329726007174	ATP binding site [chemical binding]; other site
329726007175	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726007176	ABC transporter signature motif; other site
329726007177	Walker B; other site
329726007178	D-loop; other site
329726007179	H-loop/switch region; other site
329726007180	CAAX protease self-immunity; Region: Abi; pfam02517
329726007181	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
329726007182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007183	binding surface
329726007184	TPR motif; other site
329726007185	EamA-like transporter family; Region: EamA; pfam00892
329726007186	Predicted membrane protein [Function unknown]; Region: COG1808
329726007187	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
329726007188	ligand binding site [chemical binding]; other site
329726007189	agmatinase; Region: agmatinase; TIGR01230
329726007190	Agmatinase-like family; Region: Agmatinase-like; cd09990
329726007191	active site
329726007192	oligomer interface [polypeptide binding]; other site
329726007193	Mn binding site [ion binding]; other site
329726007194	hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100
329726007195	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
329726007196	hydrogenase accessory protein HypB; Region: hypB; TIGR00073
329726007197	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
329726007198	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
329726007199	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
329726007200	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726007201	dimer interface [polypeptide binding]; other site
329726007202	conserved gate region; other site
329726007203	ABC-ATPase subunit interface; other site
329726007204	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
329726007205	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
329726007206	Walker A/P-loop; other site
329726007207	ATP binding site [chemical binding]; other site
329726007208	Q-loop/lid; other site
329726007209	ABC transporter signature motif; other site
329726007210	Walker B; other site
329726007211	D-loop; other site
329726007212	H-loop/switch region; other site
329726007213	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
329726007214	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726007215	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726007216	active site
329726007217	ATP binding site [chemical binding]; other site
329726007218	substrate binding site [chemical binding]; other site
329726007219	activation loop (A-loop); other site
329726007220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007221	TPR motif; other site
329726007222	binding surface
329726007223	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726007224	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007225	binding surface
329726007226	TPR motif; other site
329726007227	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007228	binding surface
329726007229	TPR motif; other site
329726007230	TPR repeat; Region: TPR_11; pfam13414
329726007231	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007232	binding surface
329726007233	TPR motif; other site
329726007234	TPR repeat; Region: TPR_11; pfam13414
329726007235	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007236	binding surface
329726007237	TPR motif; other site
329726007238	TPR repeat; Region: TPR_11; pfam13414
329726007239	TPR repeat; Region: TPR_11; pfam13414
329726007240	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816
329726007241	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
329726007242	dimer interface [polypeptide binding]; other site
329726007243	active site
329726007244	TPR repeat; Region: TPR_11; pfam13414
329726007245	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007246	binding surface
329726007247	TPR motif; other site
329726007248	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
329726007249	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007250	binding surface
329726007251	TPR motif; other site
329726007252	TPR repeat; Region: TPR_11; pfam13414
329726007253	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007254	binding surface
329726007255	TPR motif; other site
329726007256	TPR repeat; Region: TPR_11; pfam13414
329726007257	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
329726007258	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
329726007259	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
329726007260	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
329726007261	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
329726007262	pheophorbide a oxygenase; Region: PLN02518
329726007263	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
329726007264	iron-sulfur cluster [ion binding]; other site
329726007265	[2Fe-2S] cluster binding site [ion binding]; other site
329726007266	Pheophorbide a oxygenase; Region: PaO; pfam08417
329726007267	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
329726007268	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
329726007269	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
329726007270	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
329726007271	ribonuclease PH; Reviewed; Region: rph; PRK00173
329726007272	Ribonuclease PH; Region: RNase_PH_bact; cd11362
329726007273	hexamer interface [polypeptide binding]; other site
329726007274	active site
329726007275	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
329726007276	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
329726007277	trimer interface [polypeptide binding]; other site
329726007278	active site
329726007279	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
329726007280	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
329726007281	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
329726007282	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726007283	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726007284	phosphopeptide binding site; other site
329726007285	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726007286	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726007287	metal binding site [ion binding]; metal-binding site
329726007288	active site
329726007289	I-site; other site
329726007290	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726007291	ribosomal protein L19; Region: rpl19; CHL00084
329726007292	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
329726007293	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
329726007294	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
329726007295	putative homodimer interface [polypeptide binding]; other site
329726007296	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
329726007297	heterodimer interface [polypeptide binding]; other site
329726007298	homodimer interface [polypeptide binding]; other site
329726007299	Ribosomal protein L11/L12; Region: RL11; smart00649
329726007300	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
329726007301	putative thiostrepton binding site; other site
329726007302	23S rRNA interface [nucleotide binding]; other site
329726007303	L7/L12 interface [polypeptide binding]; other site
329726007304	L25 interface [polypeptide binding]; other site
329726007305	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
329726007306	mRNA/rRNA interface [nucleotide binding]; other site
329726007307	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
329726007308	23S rRNA interface [nucleotide binding]; other site
329726007309	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
329726007310	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
329726007311	peripheral dimer interface [polypeptide binding]; other site
329726007312	core dimer interface [polypeptide binding]; other site
329726007313	L10 interface [polypeptide binding]; other site
329726007314	L11 interface [polypeptide binding]; other site
329726007315	putative EF-Tu interaction site [polypeptide binding]; other site
329726007316	putative EF-G interaction site [polypeptide binding]; other site
329726007317	Protein of unknown function (DUF552); Region: DUF552; pfam04472
329726007318	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726007319	Coenzyme A binding pocket [chemical binding]; other site
329726007320	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
329726007321	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726007322	phosphopeptide binding site; other site
329726007323	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726007324	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726007325	phosphopeptide binding site; other site
329726007326	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726007327	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726007328	phosphopeptide binding site; other site
329726007329	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
329726007330	Walker A/P-loop; other site
329726007331	ATP binding site [chemical binding]; other site
329726007332	ABC transporter; Region: ABC_tran; pfam00005
329726007333	Q-loop/lid; other site
329726007334	ABC transporter signature motif; other site
329726007335	Walker B; other site
329726007336	D-loop; other site
329726007337	H-loop/switch region; other site
329726007338	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
329726007339	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
329726007340	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
329726007341	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726007342	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
329726007343	AMP binding site [chemical binding]; other site
329726007344	metal binding site [ion binding]; metal-binding site
329726007345	active site
329726007346	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
329726007347	putative active site [active]
329726007348	transaldolase; Provisional; Region: PRK03903
329726007349	catalytic residue [active]
329726007350	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
329726007351	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
329726007352	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
329726007353	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
329726007354	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
329726007355	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
329726007356	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
329726007357	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
329726007358	catalytic triad [active]
329726007359	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
329726007360	RuvA N terminal domain; Region: RuvA_N; pfam01330
329726007361	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
329726007362	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
329726007363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726007364	Major Facilitator Superfamily; Region: MFS_1; pfam07690
329726007365	putative substrate translocation pore; other site
329726007366	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
329726007367	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726007368	active site
329726007369	ATP binding site [chemical binding]; other site
329726007370	substrate binding site [chemical binding]; other site
329726007371	activation loop (A-loop); other site
329726007372	hydrolase, alpha/beta fold family protein; Region: PLN02824
329726007373	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726007374	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
329726007375	protein I interface; other site
329726007376	D2 interface; other site
329726007377	protein T interface; other site
329726007378	chlorophyll binding site; other site
329726007379	beta carotene binding site; other site
329726007380	pheophytin binding site; other site
329726007381	manganese-stabilizing polypeptide interface; other site
329726007382	CP43 interface; other site
329726007383	protein L interface; other site
329726007384	oxygen evolving complex binding site; other site
329726007385	bromide binding site; other site
329726007386	quinone binding site; other site
329726007387	Fe binding site [ion binding]; other site
329726007388	core light harvesting interface; other site
329726007389	cytochrome b559 alpha subunit interface; other site
329726007390	cytochrome c-550 interface; other site
329726007391	protein J interface; other site
329726007392	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
329726007393	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
329726007394	DHH family; Region: DHH; pfam01368
329726007395	DHHA1 domain; Region: DHHA1; pfam02272
329726007396	Flagellin N-methylase; Region: FliB; pfam03692
329726007397	Predicted membrane protein [Function unknown]; Region: COG2119
329726007398	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
329726007399	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
329726007400	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
329726007401	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
329726007402	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
329726007403	Uncharacterized conserved protein [Function unknown]; Region: COG0327
329726007404	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
329726007405	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
329726007406	histidinol dehydrogenase; Region: hisD; TIGR00069
329726007407	NAD binding site [chemical binding]; other site
329726007408	dimerization interface [polypeptide binding]; other site
329726007409	product binding site; other site
329726007410	substrate binding site [chemical binding]; other site
329726007411	zinc binding site [ion binding]; other site
329726007412	catalytic residues [active]
329726007413	Phosphotransferase enzyme family; Region: APH; pfam01636
329726007414	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
329726007415	active site
329726007416	ATP binding site [chemical binding]; other site
329726007417	substrate binding site [chemical binding]; other site
329726007418	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
329726007419	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726007420	pheophorbide a oxygenase; Region: PLN02518
329726007421	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
329726007422	iron-sulfur cluster [ion binding]; other site
329726007423	[2Fe-2S] cluster binding site [ion binding]; other site
329726007424	Pheophorbide a oxygenase; Region: PaO; pfam08417
329726007425	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
329726007426	Uncharacterized conserved protein [Function unknown]; Region: COG3791
329726007427	aromatic acid decarboxylase; Validated; Region: PRK05920
329726007428	Flavoprotein; Region: Flavoprotein; pfam02441
329726007429	Predicted integral membrane protein [Function unknown]; Region: COG5652
329726007430	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726007431	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
329726007432	dimer interface [polypeptide binding]; other site
329726007433	putative metal binding site [ion binding]; other site
329726007434	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
329726007435	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
329726007436	MOSC domain; Region: MOSC; pfam03473
329726007437	CTP synthetase; Validated; Region: pyrG; PRK05380
329726007438	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
329726007439	Catalytic site [active]
329726007440	active site
329726007441	UTP binding site [chemical binding]; other site
329726007442	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
329726007443	active site
329726007444	putative oxyanion hole; other site
329726007445	catalytic triad [active]
329726007446	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
329726007447	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
329726007448	nucleotide binding site [chemical binding]; other site
329726007449	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
329726007450	homotrimer interaction site [polypeptide binding]; other site
329726007451	zinc binding site [ion binding]; other site
329726007452	CDP-binding sites; other site
329726007453	single-stranded DNA-binding protein; Region: PHA00458
329726007454	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
329726007455	Domain of unknown function DUF21; Region: DUF21; pfam01595
329726007456	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
329726007457	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
329726007458	Transporter associated domain; Region: CorC_HlyC; smart01091
329726007459	hypothetical protein; Provisional; Region: PRK02724
329726007460	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
329726007461	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
329726007462	catalytic residues [active]
329726007463	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
329726007464	CHAT domain; Region: CHAT; cl17868
329726007465	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
329726007466	cyclase homology domain; Region: CHD; cd07302
329726007467	nucleotidyl binding site; other site
329726007468	metal binding site [ion binding]; metal-binding site
329726007469	dimer interface [polypeptide binding]; other site
329726007470	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
329726007471	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
329726007472	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
329726007473	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
329726007474	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
329726007475	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
329726007476	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
329726007477	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
329726007478	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
329726007479	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
329726007480	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
329726007481	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
329726007482	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726007483	Coenzyme A binding pocket [chemical binding]; other site
329726007484	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
329726007485	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
329726007486	substrate binding site [chemical binding]; other site
329726007487	putative active site [active]
329726007488	redox center [active]
329726007489	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
329726007490	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
329726007491	Moco binding site; other site
329726007492	metal coordination site [ion binding]; other site
329726007493	ribosomal protein L32; Validated; Region: rpl32; CHL00152
329726007494	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726007495	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726007496	metal binding site [ion binding]; metal-binding site
329726007497	active site
329726007498	I-site; other site
329726007499	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
329726007500	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
329726007501	catalytic triad [active]
329726007502	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
329726007503	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
329726007504	dimerization interface [polypeptide binding]; other site
329726007505	FAD binding pocket [chemical binding]; other site
329726007506	FAD binding motif [chemical binding]; other site
329726007507	catalytic residues [active]
329726007508	NAD binding pocket [chemical binding]; other site
329726007509	phosphate binding motif [ion binding]; other site
329726007510	beta-alpha-beta structure motif; other site
329726007511	arogenate dehydrogenase; Reviewed; Region: PRK07417
329726007512	prephenate dehydrogenase; Validated; Region: PRK08507
329726007513	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
329726007514	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726007515	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726007516	structural tetrad; other site
329726007517	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
329726007518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726007519	dimer interface [polypeptide binding]; other site
329726007520	conserved gate region; other site
329726007521	putative PBP binding loops; other site
329726007522	ABC-ATPase subunit interface; other site
329726007523	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
329726007524	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
329726007525	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
329726007526	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
329726007527	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
329726007528	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
329726007529	putative active site [active]
329726007530	TPR repeat; Region: TPR_11; pfam13414
329726007531	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007532	binding surface
329726007533	TPR motif; other site
329726007534	TPR repeat; Region: TPR_11; pfam13414
329726007535	Tetratricopeptide repeat; Region: TPR_16; pfam13432
329726007536	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
329726007537	Coenzyme A binding pocket [chemical binding]; other site
329726007538	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
329726007539	active site
329726007540	dinuclear metal binding site [ion binding]; other site
329726007541	dimerization interface [polypeptide binding]; other site
329726007542	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
329726007543	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
329726007544	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726007545	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726007546	active site
329726007547	ATP binding site [chemical binding]; other site
329726007548	substrate binding site [chemical binding]; other site
329726007549	activation loop (A-loop); other site
329726007550	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726007551	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726007552	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726007553	dimer interface [polypeptide binding]; other site
329726007554	conserved gate region; other site
329726007555	putative PBP binding loops; other site
329726007556	ABC-ATPase subunit interface; other site
329726007557	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
329726007558	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726007559	dimer interface [polypeptide binding]; other site
329726007560	conserved gate region; other site
329726007561	putative PBP binding loops; other site
329726007562	ABC-ATPase subunit interface; other site
329726007563	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
329726007564	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
329726007565	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
329726007566	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
329726007567	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
329726007568	putative dimer interface [polypeptide binding]; other site
329726007569	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726007570	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
329726007571	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
329726007572	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
329726007573	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
329726007574	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
329726007575	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726007576	Walker A/P-loop; other site
329726007577	ATP binding site [chemical binding]; other site
329726007578	Q-loop/lid; other site
329726007579	ABC transporter signature motif; other site
329726007580	Walker B; other site
329726007581	D-loop; other site
329726007582	H-loop/switch region; other site
329726007583	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
329726007584	Rhomboid family; Region: Rhomboid; pfam01694
329726007585	CAAX protease self-immunity; Region: Abi; pfam02517
329726007586	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
329726007587	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
329726007588	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
329726007589	Cl- selectivity filter; other site
329726007590	Cl- binding residues [ion binding]; other site
329726007591	pore gating glutamate residue; other site
329726007592	dimer interface [polypeptide binding]; other site
329726007593	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
329726007594	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726007595	active site
329726007596	motif I; other site
329726007597	motif II; other site
329726007598	HEAT repeats; Region: HEAT_2; pfam13646
329726007599	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
329726007600	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
329726007601	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
329726007602	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
329726007603	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726007604	catalytic loop [active]
329726007605	iron binding site [ion binding]; other site
329726007606	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726007607	putative substrate translocation pore; other site
329726007608	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726007609	S-layer homology domain; Region: SLH; pfam00395
329726007610	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
329726007611	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
329726007612	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
329726007613	[4Fe-4S] binding site [ion binding]; other site
329726007614	molybdopterin cofactor binding site; other site
329726007615	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
329726007616	molybdopterin cofactor binding site; other site
329726007617	multifunctional aminopeptidase A; Provisional; Region: PRK00913
329726007618	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
329726007619	interface (dimer of trimers) [polypeptide binding]; other site
329726007620	Substrate-binding/catalytic site; other site
329726007621	Zn-binding sites [ion binding]; other site
329726007622	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
329726007623	dimer interface [polypeptide binding]; other site
329726007624	FMN binding site [chemical binding]; other site
329726007625	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726007626	SnoaL-like domain; Region: SnoaL_3; pfam13474
329726007627	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
329726007628	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
329726007629	putative dimer interface [polypeptide binding]; other site
329726007630	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726007631	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726007632	ligand binding site [chemical binding]; other site
329726007633	flexible hinge region; other site
329726007634	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
329726007635	nudix motif; other site
329726007636	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726007637	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726007638	metal binding site [ion binding]; metal-binding site
329726007639	active site
329726007640	I-site; other site
329726007641	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726007642	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
329726007643	cyclase homology domain; Region: CHD; cd07302
329726007644	dimer interface [polypeptide binding]; other site
329726007645	nucleotidyl binding site; other site
329726007646	metal binding site [ion binding]; metal-binding site
329726007647	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
329726007648	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
329726007649	Rab subfamily motif 1 (RabSF1); other site
329726007650	G1 box; other site
329726007651	GTP/Mg2+ binding site [chemical binding]; other site
329726007652	Rab subfamily motif 2 (RabSF2); other site
329726007653	Switch I region; other site
329726007654	G2 box; other site
329726007655	effector interaction site; other site
329726007656	GDI interaction site; other site
329726007657	Rab family motif 1 (RabF1); other site
329726007658	GEF interaction site [polypeptide binding]; other site
329726007659	Rab family motif 2 (RabF2); other site
329726007660	G3 box; other site
329726007661	Switch II region; other site
329726007662	Rab family motif 3 (RabF3); other site
329726007663	Rab family motif 4 (RabF4); other site
329726007664	Rab family motif 5 (RabF5); other site
329726007665	Rab subfamily motif 3 (RabSF3); other site
329726007666	G4 box; other site
329726007667	G5 box; other site
329726007668	Rab subfamily motif 4 (RabSF4); other site
329726007669	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
329726007670	ligand binding site [chemical binding]; other site
329726007671	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
329726007672	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
329726007673	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
329726007674	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
329726007675	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726007676	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
329726007677	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
329726007678	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
329726007679	RNA binding site [nucleotide binding]; other site
329726007680	active site
329726007681	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
329726007682	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
329726007683	amidase catalytic site [active]
329726007684	Zn binding residues [ion binding]; other site
329726007685	substrate binding site [chemical binding]; other site
329726007686	Bacterial Ig-like domain; Region: Big_5; pfam13205
329726007687	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
329726007688	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
329726007689	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
329726007690	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
329726007691	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
329726007692	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
329726007693	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726007694	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
329726007695	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726007696	Coenzyme A binding pocket [chemical binding]; other site
329726007697	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
329726007698	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726007699	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
329726007700	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
329726007701	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
329726007702	dimerization interface [polypeptide binding]; other site
329726007703	putative DNA binding site [nucleotide binding]; other site
329726007704	putative Zn2+ binding site [ion binding]; other site
329726007705	Domain of unknown function DUF29; Region: DUF29; pfam01724
329726007706	Homeodomain-like domain; Region: HTH_23; pfam13384
329726007707	Winged helix-turn helix; Region: HTH_29; pfam13551
329726007708	Homeodomain-like domain; Region: HTH_32; pfam13565
329726007709	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726007710	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
329726007711	hypothetical protein; Provisional; Region: PRK05409
329726007712	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
329726007713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337
329726007714	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
329726007715	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726007716	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726007717	structural tetrad; other site
329726007718	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
329726007719	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
329726007720	P-loop, Walker A motif; other site
329726007721	Base recognition motif; other site
329726007722	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
329726007723	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
329726007724	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726007725	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726007726	DNA binding residues [nucleotide binding]
329726007727	dimerization interface [polypeptide binding]; other site
329726007728	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
329726007729	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
329726007730	conserved cys residue [active]
329726007731	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726007732	putative active site [active]
329726007733	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726007734	metal binding site 2 [ion binding]; metal-binding site
329726007735	putative DNA binding helix; other site
329726007736	metal binding site 1 [ion binding]; metal-binding site
329726007737	dimer interface [polypeptide binding]; other site
329726007738	structural Zn2+ binding site [ion binding]; other site
329726007739	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
329726007740	G1 box; other site
329726007741	GTP/Mg2+ binding site [chemical binding]; other site
329726007742	G2 box; other site
329726007743	Switch I region; other site
329726007744	G3 box; other site
329726007745	Switch II region; other site
329726007746	G4 box; other site
329726007747	G5 box; other site
329726007748	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
329726007749	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
329726007750	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
329726007751	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726007752	putative active site [active]
329726007753	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726007754	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726007755	metal binding site [ion binding]; metal-binding site
329726007756	active site
329726007757	I-site; other site
329726007758	Protein of unknown function (DUF2396); Region: DUF2396; cl09868
329726007759	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
329726007760	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726007761	structural tetrad; other site
329726007762	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726007763	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
329726007764	ligand binding site [chemical binding]; other site
329726007765	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
329726007766	putative switch regulator; other site
329726007767	non-specific DNA interactions [nucleotide binding]; other site
329726007768	DNA binding site [nucleotide binding]
329726007769	sequence specific DNA binding site [nucleotide binding]; other site
329726007770	putative cAMP binding site [chemical binding]; other site
329726007771	Protein of unknown function (DUF1636); Region: DUF1636; cl17843
329726007772	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
329726007773	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
329726007774	trimer interface [polypeptide binding]; other site
329726007775	active site
329726007776	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cl01843
329726007777	putative multimerization interface [polypeptide binding]; other site
329726007778	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
329726007779	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
329726007780	SnoaL-like domain; Region: SnoaL_3; pfam13474
329726007781	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
329726007782	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
329726007783	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
329726007784	active site
329726007785	dimer interface [polypeptide binding]; other site
329726007786	motif 1; other site
329726007787	motif 2; other site
329726007788	motif 3; other site
329726007789	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
329726007790	anticodon binding site; other site
329726007791	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
329726007792	homodecamer interface [polypeptide binding]; other site
329726007793	GTP cyclohydrolase I; Provisional; Region: PLN03044
329726007794	active site
329726007795	putative catalytic site residues [active]
329726007796	zinc binding site [ion binding]; other site
329726007797	GTP-CH-I/GFRP interaction surface; other site
329726007798	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
329726007799	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
329726007800	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
329726007801	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
329726007802	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
329726007803	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
329726007804	active site
329726007805	metal binding site [ion binding]; metal-binding site
329726007806	Domain of unknown function (DUF3893); Region: DUF3893; pfam13032
329726007807	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
329726007808	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
329726007809	ATP binding site [chemical binding]; other site
329726007810	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
329726007811	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726007812	sequence-specific DNA binding site [nucleotide binding]; other site
329726007813	salt bridge; other site
329726007814	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
329726007815	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
329726007816	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
329726007817	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
329726007818	dimer interface [polypeptide binding]; other site
329726007819	active site
329726007820	aspartate-rich active site metal binding site; other site
329726007821	allosteric magnesium binding site [ion binding]; other site
329726007822	Schiff base residues; other site
329726007823	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
329726007824	intersubunit interface [polypeptide binding]; other site
329726007825	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
329726007826	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
329726007827	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
329726007828	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
329726007829	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
329726007830	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
329726007831	ABC-ATPase subunit  interface; other site
329726007832	dimer interface [polypeptide binding]; other site
329726007833	putative PBP binding regions; other site
329726007834	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
329726007835	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
329726007836	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
329726007837	active site
329726007838	dimer interface [polypeptide binding]; other site
329726007839	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
329726007840	active site
329726007841	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
329726007842	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
329726007843	active site
329726007844	catalytic site [active]
329726007845	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
329726007846	DNA adenine methylase (dam); Region: dam; TIGR00571
329726007847	Protein of unknown function (DUF751); Region: DUF751; pfam05421
329726007848	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
329726007849	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
329726007850	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
329726007851	NACHT domain; Region: NACHT; pfam05729
329726007852	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726007853	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726007854	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726007855	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726007856	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726007857	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
329726007858	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
329726007859	PYR/PP interface [polypeptide binding]; other site
329726007860	dimer interface [polypeptide binding]; other site
329726007861	TPP binding site [chemical binding]; other site
329726007862	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
329726007863	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
329726007864	TPP-binding site [chemical binding]; other site
329726007865	dimer interface [polypeptide binding]; other site
329726007866	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
329726007867	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726007868	H+ Antiporter protein; Region: 2A0121; TIGR00900
329726007869	putative substrate translocation pore; other site
329726007870	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
329726007871	30S subunit binding site; other site
329726007872	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
329726007873	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
329726007874	MoaE homodimer interface [polypeptide binding]; other site
329726007875	MoaD interaction [polypeptide binding]; other site
329726007876	active site residues [active]
329726007877	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
329726007878	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
329726007879	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
329726007880	G-X-X-G motif; other site
329726007881	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
329726007882	RxxxH motif; other site
329726007883	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
329726007884	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
329726007885	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
329726007886	Bacterial PH domain; Region: DUF304; pfam03703
329726007887	ribonuclease P; Reviewed; Region: rnpA; PRK03031
329726007888	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
329726007889	DnaA N-terminal domain; Region: DnaA_N; pfam11638
329726007890	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726007891	Walker A motif; other site
329726007892	ATP binding site [chemical binding]; other site
329726007893	Walker B motif; other site
329726007894	arginine finger; other site
329726007895	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
329726007896	DnaA box-binding interface [nucleotide binding]; other site
329726007897	DNA polymerase III subunit beta; Validated; Region: PRK05643
329726007898	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
329726007899	putative DNA binding surface [nucleotide binding]; other site
329726007900	dimer interface [polypeptide binding]; other site
329726007901	beta-clamp/clamp loader binding surface; other site
329726007902	beta-clamp/translesion DNA polymerase binding surface; other site
329726007903	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
329726007904	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
329726007905	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
329726007906	Ligand binding site; other site
329726007907	Putative Catalytic site; other site
329726007908	DXD motif; other site
329726007909	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726007910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726007911	active site
329726007912	phosphorylation site [posttranslational modification]
329726007913	intermolecular recognition site; other site
329726007914	dimerization interface [polypeptide binding]; other site
329726007915	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726007916	DNA binding residues [nucleotide binding]
329726007917	dimerization interface [polypeptide binding]; other site
329726007918	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
329726007919	Low molecular weight phosphatase family; Region: LMWPc; cd00115
329726007920	active site
329726007921	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
329726007922	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
329726007923	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726007924	BT1 family; Region: BT1; pfam03092
329726007925	putative substrate translocation pore; other site
329726007926	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
329726007927	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726007928	NAD(P) binding site [chemical binding]; other site
329726007929	active site
329726007930	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726007931	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726007932	catalytic loop [active]
329726007933	iron binding site [ion binding]; other site
329726007934	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
329726007935	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
329726007936	NAD(P) binding site [chemical binding]; other site
329726007937	catalytic residues [active]
329726007938	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
329726007939	ADP-ribose binding site [chemical binding]; other site
329726007940	DNA gyrase subunit A; Validated; Region: PRK05560
329726007941	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
329726007942	CAP-like domain; other site
329726007943	active site
329726007944	primary dimer interface [polypeptide binding]; other site
329726007945	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
329726007946	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
329726007947	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
329726007948	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
329726007949	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
329726007950	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
329726007951	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
329726007952	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
329726007953	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
329726007954	active site
329726007955	homodimer interface [polypeptide binding]; other site
329726007956	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
329726007957	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
329726007958	Walker A motif; other site
329726007959	ATP binding site [chemical binding]; other site
329726007960	Walker B motif; other site
329726007961	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
329726007962	tetramer interface [polypeptide binding]; other site
329726007963	dimer interface [polypeptide binding]; other site
329726007964	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
329726007965	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726007966	motif II; other site
329726007967	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
329726007968	active site
329726007969	putative substrate binding region [chemical binding]; other site
329726007970	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007971	binding surface
329726007972	TPR motif; other site
329726007973	TPR repeat; Region: TPR_11; pfam13414
329726007974	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726007975	binding surface
329726007976	TPR motif; other site
329726007977	Tetratricopeptide repeat; Region: TPR_9; pfam13371
329726007978	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
329726007979	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
329726007980	ATP-grasp domain; Region: ATP-grasp_4; cl17255
329726007981	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
329726007982	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
329726007983	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
329726007984	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
329726007985	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
329726007986	short chain dehydrogenase; Validated; Region: PRK08264
329726007987	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726007988	NAD(P) binding site [chemical binding]; other site
329726007989	active site
329726007990	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726007991	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726007992	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
329726007993	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
329726007994	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
329726007995	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
329726007996	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
329726007997	SdiA-regulated; Region: SdiA-regulated; cd09971
329726007998	putative active site [active]
329726007999	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
329726008000	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
329726008001	Catalytic site [active]
329726008002	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
329726008003	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
329726008004	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
329726008005	Catalytic site [active]
329726008006	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
329726008007	AAA ATPase domain; Region: AAA_16; pfam13191
329726008008	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
329726008009	active site
329726008010	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
329726008011	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726008012	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
329726008013	active site
329726008014	metal binding site [ion binding]; metal-binding site
329726008015	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
329726008016	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
329726008017	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
329726008018	Ca2+ binding site [ion binding]; other site
329726008019	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
329726008020	EF-hand domain pair; Region: EF_hand_5; pfam13499
329726008021	Ca2+ binding site [ion binding]; other site
329726008022	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
329726008023	NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...; Region: NOX_Duox_like_FAD_NADP; cd06186
329726008024	FAD binding pocket [chemical binding]; other site
329726008025	FAD binding motif [chemical binding]; other site
329726008026	Ferric reductase NAD binding domain; Region: NAD_binding_6; pfam08030
329726008027	NAD pyrophosphate binding region [chemical binding]; other site
329726008028	beta-alpha-beta stucture motif; other site
329726008029	NAD binding pocket [chemical binding]; other site
329726008030	NADP ribose binding motif [chemical binding]; other site
329726008031	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
329726008032	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
329726008033	NAD binding site [chemical binding]; other site
329726008034	homotetramer interface [polypeptide binding]; other site
329726008035	homodimer interface [polypeptide binding]; other site
329726008036	substrate binding site [chemical binding]; other site
329726008037	active site
329726008038	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726008039	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
329726008040	ligand binding site [chemical binding]; other site
329726008041	flexible hinge region; other site
329726008042	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
329726008043	putative switch regulator; other site
329726008044	non-specific DNA interactions [nucleotide binding]; other site
329726008045	DNA binding site [nucleotide binding]
329726008046	sequence specific DNA binding site [nucleotide binding]; other site
329726008047	putative cAMP binding site [chemical binding]; other site
329726008048	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
329726008049	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
329726008050	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
329726008051	shikimate binding site; other site
329726008052	NAD(P) binding site [chemical binding]; other site
329726008053	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
329726008054	Nitrogen regulatory protein P-II; Region: P-II; smart00938
329726008055	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
329726008056	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726008057	Walker A/P-loop; other site
329726008058	ATP binding site [chemical binding]; other site
329726008059	Q-loop/lid; other site
329726008060	ABC transporter signature motif; other site
329726008061	Walker B; other site
329726008062	D-loop; other site
329726008063	H-loop/switch region; other site
329726008064	TOBE domain; Region: TOBE_2; pfam08402
329726008065	Protein kinase domain; Region: Pkinase; pfam00069
329726008066	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726008067	active site
329726008068	ATP binding site [chemical binding]; other site
329726008069	substrate binding site [chemical binding]; other site
329726008070	activation loop (A-loop); other site
329726008071	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
329726008072	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
329726008073	dimer interface [polypeptide binding]; other site
329726008074	ssDNA binding site [nucleotide binding]; other site
329726008075	tetramer (dimer of dimers) interface [polypeptide binding]; other site
329726008076	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
329726008077	Domain of unknown function DUF20; Region: UPF0118; pfam01594
329726008078	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
329726008079	dimer interface [polypeptide binding]; other site
329726008080	motif 1; other site
329726008081	active site
329726008082	motif 2; other site
329726008083	motif 3; other site
329726008084	YacP-like NYN domain; Region: NYN_YacP; pfam05991
329726008085	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
329726008086	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726008087	metal binding site 2 [ion binding]; metal-binding site
329726008088	putative DNA binding helix; other site
329726008089	metal binding site 1 [ion binding]; metal-binding site
329726008090	dimer interface [polypeptide binding]; other site
329726008091	structural Zn2+ binding site [ion binding]; other site
329726008092	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
329726008093	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
329726008094	active site
329726008095	Substrate binding site; other site
329726008096	Mg++ binding site; other site
329726008097	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
329726008098	putative trimer interface [polypeptide binding]; other site
329726008099	putative CoA binding site [chemical binding]; other site
329726008100	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
329726008101	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
329726008102	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
329726008103	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
329726008104	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726008105	TPR motif; other site
329726008106	binding surface
329726008107	hydrolase, alpha/beta fold family protein; Region: PLN02824
329726008108	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726008109	Methyltransferase domain; Region: Methyltransf_11; pfam08241
329726008110	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
329726008111	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
329726008112	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726008113	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726008114	ligand binding site [chemical binding]; other site
329726008115	flexible hinge region; other site
329726008116	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
329726008117	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
329726008118	putative active site [active]
329726008119	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726008120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726008121	Walker A/P-loop; other site
329726008122	ATP binding site [chemical binding]; other site
329726008123	Q-loop/lid; other site
329726008124	ABC transporter signature motif; other site
329726008125	Walker B; other site
329726008126	D-loop; other site
329726008127	H-loop/switch region; other site
329726008128	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
329726008129	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
329726008130	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726008131	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726008132	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726008133	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726008134	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
329726008135	DNA binding residues [nucleotide binding]
329726008136	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
329726008137	dimer interface [polypeptide binding]; other site
329726008138	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726008139	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726008140	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726008141	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726008142	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726008143	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726008144	phosphopeptide binding site; other site
329726008145	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726008146	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726008147	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
329726008148	cyclase homology domain; Region: CHD; cd07302
329726008149	nucleotidyl binding site; other site
329726008150	metal binding site [ion binding]; metal-binding site
329726008151	dimer interface [polypeptide binding]; other site
329726008152	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
329726008153	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726008154	active site
329726008155	ATP binding site [chemical binding]; other site
329726008156	substrate binding site [chemical binding]; other site
329726008157	activation loop (A-loop); other site
329726008158	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
329726008159	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
329726008160	EamA-like transporter family; Region: EamA; pfam00892
329726008161	EamA-like transporter family; Region: EamA; pfam00892
329726008162	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726008163	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726008164	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
329726008165	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
329726008166	active site
329726008167	catalytic residues [active]
329726008168	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
329726008169	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
329726008170	putative ADP-binding pocket [chemical binding]; other site
329726008171	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
329726008172	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
329726008173	Sulfate transporter family; Region: Sulfate_transp; pfam00916
329726008174	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
329726008175	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
329726008176	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
329726008177	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
329726008178	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
329726008179	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
329726008180	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
329726008181	hypothetical protein; Provisional; Region: PRK07377
329726008182	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
329726008183	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726008184	putative active site [active]
329726008185	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
329726008186	nitrite reductase subunit NirD; Provisional; Region: PRK14989
329726008187	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
329726008188	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
329726008189	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
329726008190	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726008191	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726008192	active site
329726008193	ATP binding site [chemical binding]; other site
329726008194	substrate binding site [chemical binding]; other site
329726008195	activation loop (A-loop); other site
329726008196	Electron transfer DM13; Region: DM13; pfam10517
329726008197	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
329726008198	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
329726008199	ring oligomerisation interface [polypeptide binding]; other site
329726008200	ATP/Mg binding site [chemical binding]; other site
329726008201	stacking interactions; other site
329726008202	hinge regions; other site
329726008203	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
329726008204	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
329726008205	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726008206	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726008207	TPR repeat; Region: TPR_11; pfam13414
329726008208	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726008209	binding surface
329726008210	TPR motif; other site
329726008211	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726008212	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726008213	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
329726008214	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
329726008215	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
329726008216	active site
329726008217	metal binding site [ion binding]; metal-binding site
329726008218	DNA binding site [nucleotide binding]
329726008219	Protein of unknown function, DUF393; Region: DUF393; pfam04134
329726008220	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
329726008221	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
329726008222	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726008223	NAD(P) binding site [chemical binding]; other site
329726008224	active site
329726008225	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726008226	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726008227	Coenzyme A binding pocket [chemical binding]; other site
329726008228	Ycf27; Reviewed; Region: orf27; CHL00148
329726008229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726008230	active site
329726008231	phosphorylation site [posttranslational modification]
329726008232	intermolecular recognition site; other site
329726008233	dimerization interface [polypeptide binding]; other site
329726008234	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726008235	DNA binding site [nucleotide binding]
329726008236	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726008237	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726008238	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
329726008239	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726008240	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726008241	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726008242	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
329726008243	FtsH Extracellular; Region: FtsH_ext; pfam06480
329726008244	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
329726008245	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726008246	Walker A motif; other site
329726008247	ATP binding site [chemical binding]; other site
329726008248	Walker B motif; other site
329726008249	arginine finger; other site
329726008250	Peptidase family M41; Region: Peptidase_M41; pfam01434
329726008251	Predicted transporter component [General function prediction only]; Region: COG2391
329726008252	Sulphur transport; Region: Sulf_transp; pfam04143
329726008253	Predicted transporter component [General function prediction only]; Region: COG2391
329726008254	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
329726008255	Response regulator receiver domain; Region: Response_reg; pfam00072
329726008256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726008257	active site
329726008258	phosphorylation site [posttranslational modification]
329726008259	intermolecular recognition site; other site
329726008260	dimerization interface [polypeptide binding]; other site
329726008261	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
329726008262	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
329726008263	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
329726008264	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
329726008265	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
329726008266	NAD(P) binding site [chemical binding]; other site
329726008267	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371
329726008268	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
329726008269	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726008270	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726008271	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
329726008272	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
329726008273	Predicted flavoprotein [General function prediction only]; Region: COG0431
329726008274	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
329726008275	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726008276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726008277	binding surface
329726008278	TPR repeat; Region: TPR_11; pfam13414
329726008279	TPR motif; other site
329726008280	TPR repeat; Region: TPR_11; pfam13414
329726008281	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726008282	binding surface
329726008283	TPR motif; other site
329726008284	TPR repeat; Region: TPR_11; pfam13414
329726008285	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726008286	binding surface
329726008287	TPR motif; other site
329726008288	TPR repeat; Region: TPR_11; pfam13414
329726008289	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726008290	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726008291	ligand binding site [chemical binding]; other site
329726008292	flexible hinge region; other site
329726008293	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726008294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726008295	ATP binding site [chemical binding]; other site
329726008296	Mg2+ binding site [ion binding]; other site
329726008297	G-X-G motif; other site
329726008298	Response regulator receiver domain; Region: Response_reg; pfam00072
329726008299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726008300	active site
329726008301	phosphorylation site [posttranslational modification]
329726008302	intermolecular recognition site; other site
329726008303	dimerization interface [polypeptide binding]; other site
329726008304	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
329726008305	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
329726008306	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
329726008307	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
329726008308	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726008309	active site
329726008310	AAA ATPase domain; Region: AAA_16; pfam13191
329726008311	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726008312	structural tetrad; other site
329726008313	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726008314	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726008315	structural tetrad; other site
329726008316	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726008317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
329726008318	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
329726008319	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
329726008320	Domain of unknown function (DUF4269); Region: DUF4269; pfam14091
329726008321	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
329726008322	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
329726008323	Surface antigen; Region: Bac_surface_Ag; pfam01103
329726008324	haemagglutination activity domain; Region: Haemagg_act; pfam05860
329726008325	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726008326	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726008327	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726008328	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726008329	TPR repeat; Region: TPR_11; pfam13414
329726008330	TPR repeat; Region: TPR_11; pfam13414
329726008331	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726008332	TPR motif; other site
329726008333	TPR repeat; Region: TPR_11; pfam13414
329726008334	binding surface
329726008335	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726008336	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726008337	binding surface
329726008338	TPR motif; other site
329726008339	Transposase, Mutator family; Region: Transposase_mut; pfam00872
329726008340	MULE transposase domain; Region: MULE; pfam10551
329726008341	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726008342	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726008343	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
329726008344	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
329726008345	Hexamer interface [polypeptide binding]; other site
329726008346	Hexagonal pore residue; other site
329726008347	FIST N domain; Region: FIST; pfam08495
329726008348	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
329726008349	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726008350	FIST N domain; Region: FIST; cl10701
329726008351	FIST C domain; Region: FIST_C; pfam10442
329726008352	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726008353	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726008354	metal binding site [ion binding]; metal-binding site
329726008355	active site
329726008356	I-site; other site
329726008357	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726008358	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
329726008359	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
329726008360	putative metal binding site [ion binding]; other site
329726008361	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726008362	Domain of unknown function (DUF1993); Region: DUF1993; cl01567
329726008363	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
329726008364	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
329726008365	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
329726008366	catalytic residue [active]
329726008367	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
329726008368	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
329726008369	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
329726008370	homotrimer interaction site [polypeptide binding]; other site
329726008371	putative active site [active]
329726008372	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
329726008373	Right handed beta helix region; Region: Beta_helix; pfam13229
329726008374	Right handed beta helix region; Region: Beta_helix; pfam13229
329726008375	Right handed beta helix region; Region: Beta_helix; pfam13229
329726008376	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
329726008377	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726008378	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726008379	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726008380	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726008381	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
329726008382	hypothetical protein; Provisional; Region: PRK06185
329726008383	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
329726008384	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
329726008385	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
329726008386	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
329726008387	iron-sulfur cluster [ion binding]; other site
329726008388	[2Fe-2S] cluster binding site [ion binding]; other site
329726008389	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
329726008390	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
329726008391	PYR/PP interface [polypeptide binding]; other site
329726008392	dimer interface [polypeptide binding]; other site
329726008393	tetramer interface [polypeptide binding]; other site
329726008394	TPP binding site [chemical binding]; other site
329726008395	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
329726008396	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
329726008397	TPP-binding site [chemical binding]; other site
329726008398	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
329726008399	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
329726008400	putative acyl-acceptor binding pocket; other site
329726008401	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
329726008402	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
329726008403	metal ion-dependent adhesion site (MIDAS); other site
329726008404	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
329726008405	TIGR04168 family protein; Region: TIGR04168
329726008406	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
329726008407	pyruvate kinase; Provisional; Region: PRK06354
329726008408	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
329726008409	domain interfaces; other site
329726008410	active site
329726008411	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
329726008412	Rrf2 family protein; Region: rrf2_super; TIGR00738
329726008413	Transcriptional regulator; Region: Rrf2; cl17282
329726008414	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
329726008415	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
329726008416	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
329726008417	Type II transport protein GspH; Region: GspH; pfam12019
329726008418	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
329726008419	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
329726008420	MltA specific insert domain; Region: MltA; pfam03562
329726008421	3D domain; Region: 3D; pfam06725
329726008422	PAS domain; Region: PAS_9; pfam13426
329726008423	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726008424	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726008425	metal binding site [ion binding]; metal-binding site
329726008426	active site
329726008427	I-site; other site
329726008428	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726008429	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
329726008430	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726008431	motif II; other site
329726008432	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
329726008433	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
329726008434	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
329726008435	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
329726008436	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
329726008437	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726008438	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726008439	S-adenosylmethionine binding site [chemical binding]; other site
329726008440	sulfotransferase; Region: PLN02164
329726008441	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726008442	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726008443	active site
329726008444	ATP binding site [chemical binding]; other site
329726008445	substrate binding site [chemical binding]; other site
329726008446	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
329726008447	substrate binding site [chemical binding]; other site
329726008448	activation loop (A-loop); other site
329726008449	activation loop (A-loop); other site
329726008450	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
329726008451	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
329726008452	cobalamin binding residues [chemical binding]; other site
329726008453	putative BtuC binding residues; other site
329726008454	dimer interface [polypeptide binding]; other site
329726008455	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
329726008456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726008457	putative substrate translocation pore; other site
329726008458	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
329726008459	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
329726008460	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
329726008461	generic binding surface II; other site
329726008462	generic binding surface I; other site
329726008463	Transglycosylase; Region: Transgly; pfam00912
329726008464	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
329726008465	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
329726008466	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
329726008467	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
329726008468	active site
329726008469	HIGH motif; other site
329726008470	dimer interface [polypeptide binding]; other site
329726008471	KMSKS motif; other site
329726008472	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
329726008473	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
329726008474	Walker A/P-loop; other site
329726008475	ATP binding site [chemical binding]; other site
329726008476	Q-loop/lid; other site
329726008477	ABC transporter signature motif; other site
329726008478	Walker B; other site
329726008479	D-loop; other site
329726008480	H-loop/switch region; other site
329726008481	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
329726008482	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
329726008483	ABC-ATPase subunit  interface; other site
329726008484	dimer interface [polypeptide binding]; other site
329726008485	putative PBP binding regions; other site
329726008486	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
329726008487	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
329726008488	ABC-ATPase subunit  interface; other site
329726008489	dimer interface [polypeptide binding]; other site
329726008490	putative PBP binding regions; other site
329726008491	H+ Antiporter protein; Region: 2A0121; TIGR00900
329726008492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726008493	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
329726008494	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726008495	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
329726008496	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
329726008497	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
329726008498	siderophore binding site; other site
329726008499	AMIN domain; Region: AMIN; pfam11741
329726008500	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
329726008501	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
329726008502	N-terminal plug; other site
329726008503	ligand-binding site [chemical binding]; other site
329726008504	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726008505	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726008506	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
329726008507	putative dimer interface [polypeptide binding]; other site
329726008508	putative [2Fe-2S] cluster binding site [ion binding]; other site
329726008509	Photosystem II protein; Region: PSII; cl08223
329726008510	Photosystem II protein; Region: PSII; cl08223
329726008511	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
329726008512	plastocyanin; Provisional; Region: PRK02710
329726008513	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
329726008514	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
329726008515	active site
329726008516	intersubunit interface [polypeptide binding]; other site
329726008517	catalytic residue [active]
329726008518	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
329726008519	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
329726008520	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726008521	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726008522	Homeodomain-like domain; Region: HTH_23; pfam13384
329726008523	Winged helix-turn helix; Region: HTH_29; pfam13551
329726008524	Homeodomain-like domain; Region: HTH_32; pfam13565
329726008525	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726008526	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726008527	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726008528	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726008529	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
329726008530	Coenzyme A binding pocket [chemical binding]; other site
329726008531	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
329726008532	catalytic core [active]
329726008533	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726008534	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726008535	AMIN domain; Region: AMIN; pfam11741
329726008536	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
329726008537	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
329726008538	N-terminal plug; other site
329726008539	ligand-binding site [chemical binding]; other site
329726008540	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726008541	S-adenosylmethionine binding site [chemical binding]; other site
329726008542	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
329726008543	hypothetical protein; Provisional; Region: PRK07236
329726008544	H+ Antiporter protein; Region: 2A0121; TIGR00900
329726008545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726008546	putative substrate translocation pore; other site
329726008547	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
329726008548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726008549	S-adenosylmethionine binding site [chemical binding]; other site
329726008550	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
329726008551	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
329726008552	siderophore binding site; other site
329726008553	AMIN domain; Region: AMIN; pfam11741
329726008554	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
329726008555	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
329726008556	N-terminal plug; other site
329726008557	ligand-binding site [chemical binding]; other site
329726008558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726008559	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726008560	S-adenosylmethionine binding site [chemical binding]; other site
329726008561	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
329726008562	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726008563	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
329726008564	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
329726008565	siderophore binding site; other site
329726008566	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
329726008567	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
329726008568	N-terminal plug; other site
329726008569	ligand-binding site [chemical binding]; other site
329726008570	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
329726008571	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726008572	H+ Antiporter protein; Region: 2A0121; TIGR00900
329726008573	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
329726008574	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
329726008575	siderophore binding site; other site
329726008576	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
329726008577	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
329726008578	siderophore binding site; other site
329726008579	AMIN domain; Region: AMIN; pfam11741
329726008580	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
329726008581	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
329726008582	N-terminal plug; other site
329726008583	ligand-binding site [chemical binding]; other site
329726008584	PIN domain; Region: PIN_3; pfam13470
329726008585	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726008586	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726008587	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
329726008588	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
329726008589	N-terminal plug; other site
329726008590	ligand-binding site [chemical binding]; other site
329726008591	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
329726008592	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
329726008593	dimerization interface [polypeptide binding]; other site
329726008594	DPS ferroxidase diiron center [ion binding]; other site
329726008595	ion pore; other site
329726008596	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
329726008597	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
329726008598	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
329726008599	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
329726008600	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
329726008601	ABC-ATPase subunit  interface; other site
329726008602	dimer interface [polypeptide binding]; other site
329726008603	putative PBP binding regions; other site
329726008604	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
329726008605	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
329726008606	Walker A/P-loop; other site
329726008607	ATP binding site [chemical binding]; other site
329726008608	Q-loop/lid; other site
329726008609	ABC transporter signature motif; other site
329726008610	Walker B; other site
329726008611	D-loop; other site
329726008612	H-loop/switch region; other site
329726008613	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
329726008614	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
329726008615	intersubunit interface [polypeptide binding]; other site
329726008616	Imelysin; Region: Peptidase_M75; cl09159
329726008617	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
329726008618	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
329726008619	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
329726008620	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726008621	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
329726008622	putative switch regulator; other site
329726008623	non-specific DNA interactions [nucleotide binding]; other site
329726008624	DNA binding site [nucleotide binding]
329726008625	sequence specific DNA binding site [nucleotide binding]; other site
329726008626	putative cAMP binding site [chemical binding]; other site
329726008627	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726008628	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726008629	Circadian oscillating protein COP23; Region: COP23; pfam14218
329726008630	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
329726008631	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
329726008632	putative NAD(P) binding site [chemical binding]; other site
329726008633	catalytic Zn binding site [ion binding]; other site
329726008634	structural Zn binding site [ion binding]; other site
329726008635	Bacterial SH3 domain; Region: SH3_3; pfam08239
329726008636	ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356
329726008637	elongation factor Ts; Reviewed; Region: tsf; PRK12332
329726008638	UBA/TS-N domain; Region: UBA; pfam00627
329726008639	Elongation factor TS; Region: EF_TS; pfam00889
329726008640	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
329726008641	rRNA interaction site [nucleotide binding]; other site
329726008642	S8 interaction site; other site
329726008643	putative laminin-1 binding site; other site
329726008644	RNA methyltransferase, RsmE family; Region: TIGR00046
329726008645	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
329726008646	TopoisomeraseII; Region: TOP2c; smart00433
329726008647	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
329726008648	L-asparaginase II; Region: Asparaginase_II; cl01842
329726008649	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
329726008650	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
329726008651	active site
329726008652	substrate binding site [chemical binding]; other site
329726008653	metal binding site [ion binding]; metal-binding site
329726008654	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
329726008655	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
329726008656	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
329726008657	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
329726008658	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
329726008659	HflX GTPase family; Region: HflX; cd01878
329726008660	G1 box; other site
329726008661	GTP/Mg2+ binding site [chemical binding]; other site
329726008662	Switch I region; other site
329726008663	G2 box; other site
329726008664	G3 box; other site
329726008665	Switch II region; other site
329726008666	G4 box; other site
329726008667	G5 box; other site
329726008668	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
329726008669	metal-binding site [ion binding]
329726008670	Protein of unknown function (DUF938); Region: DUF938; pfam06080
329726008671	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
329726008672	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
329726008673	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
329726008674	putative acyl-acceptor binding pocket; other site
329726008675	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
329726008676	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
329726008677	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
329726008678	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
329726008679	dihydrodipicolinate synthase; Region: dapA; TIGR00674
329726008680	dimer interface [polypeptide binding]; other site
329726008681	active site
329726008682	catalytic residue [active]
329726008683	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
329726008684	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
329726008685	trigger factor; Provisional; Region: tig; PRK01490
329726008686	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
329726008687	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
329726008688	Clp protease; Region: CLP_protease; pfam00574
329726008689	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
329726008690	oligomer interface [polypeptide binding]; other site
329726008691	active site residues [active]
329726008692	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
329726008693	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
329726008694	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726008695	Walker A motif; other site
329726008696	ATP binding site [chemical binding]; other site
329726008697	Walker B motif; other site
329726008698	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
329726008699	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726008700	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
329726008701	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
329726008702	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726008703	ATP binding site [chemical binding]; other site
329726008704	Mg2+ binding site [ion binding]; other site
329726008705	G-X-G motif; other site
329726008706	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
329726008707	ATP binding site [chemical binding]; other site
329726008708	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
329726008709	LabA_like proteins; Region: LabA_like; cd06167
329726008710	Uncharacterized conserved protein [Function unknown]; Region: COG1432
329726008711	putative metal binding site [ion binding]; other site
329726008712	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
329726008713	FOG: CBS domain [General function prediction only]; Region: COG0517
329726008714	FOG: CBS domain [General function prediction only]; Region: COG0517
329726008715	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
329726008716	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726008717	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726008718	putative active site [active]
329726008719	heme pocket [chemical binding]; other site
329726008720	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726008721	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726008722	putative active site [active]
329726008723	heme pocket [chemical binding]; other site
329726008724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726008725	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726008726	putative active site [active]
329726008727	heme pocket [chemical binding]; other site
329726008728	PAS fold; Region: PAS_4; pfam08448
329726008729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726008730	putative active site [active]
329726008731	heme pocket [chemical binding]; other site
329726008732	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726008733	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726008734	metal binding site [ion binding]; metal-binding site
329726008735	active site
329726008736	I-site; other site
329726008737	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726008738	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
329726008739	MutS domain III; Region: MutS_III; pfam05192
329726008740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726008741	Walker A/P-loop; other site
329726008742	ATP binding site [chemical binding]; other site
329726008743	Q-loop/lid; other site
329726008744	ABC transporter signature motif; other site
329726008745	Walker B; other site
329726008746	D-loop; other site
329726008747	H-loop/switch region; other site
329726008748	Smr domain; Region: Smr; pfam01713
329726008749	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726008750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726008751	active site
329726008752	phosphorylation site [posttranslational modification]
329726008753	intermolecular recognition site; other site
329726008754	dimerization interface [polypeptide binding]; other site
329726008755	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726008756	DNA binding site [nucleotide binding]
329726008757	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
329726008758	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
329726008759	DNA binding residues [nucleotide binding]
329726008760	dimer interface [polypeptide binding]; other site
329726008761	metal binding site [ion binding]; metal-binding site
329726008762	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
329726008763	GSH binding site [chemical binding]; other site
329726008764	catalytic residues [active]
329726008765	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
329726008766	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
329726008767	active site
329726008768	metal binding site [ion binding]; metal-binding site
329726008769	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726008770	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726008771	dimer interface [polypeptide binding]; other site
329726008772	phosphorylation site [posttranslational modification]
329726008773	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726008774	ATP binding site [chemical binding]; other site
329726008775	Mg2+ binding site [ion binding]; other site
329726008776	G-X-G motif; other site
329726008777	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726008778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726008779	active site
329726008780	phosphorylation site [posttranslational modification]
329726008781	intermolecular recognition site; other site
329726008782	dimerization interface [polypeptide binding]; other site
329726008783	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726008784	DNA binding site [nucleotide binding]
329726008785	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
329726008786	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
329726008787	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
329726008788	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
329726008789	active site
329726008790	catalytic site [active]
329726008791	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
329726008792	Ferritin-like domain; Region: Ferritin; pfam00210
329726008793	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
329726008794	dinuclear metal binding motif [ion binding]; other site
329726008795	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
329726008796	active site clefts [active]
329726008797	zinc binding site [ion binding]; other site
329726008798	dimer interface [polypeptide binding]; other site
329726008799	Phosphotransferase enzyme family; Region: APH; pfam01636
329726008800	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
329726008801	active site
329726008802	substrate binding site [chemical binding]; other site
329726008803	ATP binding site [chemical binding]; other site
329726008804	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
329726008805	Na binding site [ion binding]; other site
329726008806	CARDB; Region: CARDB; pfam07705
329726008807	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726008808	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
329726008809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726008810	Response regulator receiver domain; Region: Response_reg; pfam00072
329726008811	active site
329726008812	phosphorylation site [posttranslational modification]
329726008813	intermolecular recognition site; other site
329726008814	dimerization interface [polypeptide binding]; other site
329726008815	Domain of unknown function DUF20; Region: UPF0118; pfam01594
329726008816	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
329726008817	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
329726008818	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
329726008819	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
329726008820	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
329726008821	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
329726008822	Walker A/P-loop; other site
329726008823	ATP binding site [chemical binding]; other site
329726008824	Q-loop/lid; other site
329726008825	ABC transporter signature motif; other site
329726008826	Walker B; other site
329726008827	D-loop; other site
329726008828	H-loop/switch region; other site
329726008829	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
329726008830	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726008831	dimer interface [polypeptide binding]; other site
329726008832	conserved gate region; other site
329726008833	putative PBP binding loops; other site
329726008834	ABC-ATPase subunit interface; other site
329726008835	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
329726008836	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726008837	dimer interface [polypeptide binding]; other site
329726008838	conserved gate region; other site
329726008839	putative PBP binding loops; other site
329726008840	ABC-ATPase subunit interface; other site
329726008841	PBP superfamily domain; Region: PBP_like_2; cl17296
329726008842	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
329726008843	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
329726008844	dimerization interface [polypeptide binding]; other site
329726008845	putative DNA binding site [nucleotide binding]; other site
329726008846	putative Zn2+ binding site [ion binding]; other site
329726008847	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
329726008848	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
329726008849	active site
329726008850	catalytic site [active]
329726008851	substrate binding site [chemical binding]; other site
329726008852	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
329726008853	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
329726008854	Leucine rich repeat; Region: LRR_8; pfam13855
329726008855	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
329726008856	Leucine-rich repeats; other site
329726008857	Substrate binding site [chemical binding]; other site
329726008858	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
329726008859	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
329726008860	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
329726008861	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
329726008862	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
329726008863	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
329726008864	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
329726008865	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726008866	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726008867	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726008868	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726008869	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726008870	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726008871	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
329726008872	Caspase domain; Region: Peptidase_C14; pfam00656
329726008873	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726008874	structural tetrad; other site
329726008875	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726008876	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726008877	structural tetrad; other site
329726008878	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
329726008879	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726008880	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726008881	metal binding site [ion binding]; metal-binding site
329726008882	active site
329726008883	I-site; other site
329726008884	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
329726008885	PhoD-like phosphatase; Region: PhoD; pfam09423
329726008886	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
329726008887	putative active site [active]
329726008888	putative metal binding site [ion binding]; other site
329726008889	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
329726008890	Protein of unknown function (DUF962); Region: DUF962; pfam06127
329726008891	FecR protein; Region: FecR; pfam04773
329726008892	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
329726008893	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
329726008894	hypothetical protein; Provisional; Region: PRK06771
329726008895	hypothetical protein; Provisional; Region: PRK06771
329726008896	hypothetical protein; Provisional; Region: PRK06771
329726008897	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
329726008898	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726008899	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726008900	binding surface
329726008901	TPR motif; other site
329726008902	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726008903	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726008904	binding surface
329726008905	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726008906	TPR motif; other site
329726008907	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726008908	putative active site [active]
329726008909	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
329726008910	NAD(P) binding pocket [chemical binding]; other site
329726008911	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
329726008912	amphipathic channel; other site
329726008913	Asn-Pro-Ala signature motifs; other site
329726008914	Predicted methyltransferases [General function prediction only]; Region: COG0313
329726008915	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
329726008916	putative SAM binding site [chemical binding]; other site
329726008917	putative homodimer interface [polypeptide binding]; other site
329726008918	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
329726008919	Uncharacterized conserved protein [Function unknown]; Region: COG0398
329726008920	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
329726008921	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
329726008922	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
329726008923	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
329726008924	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
329726008925	putative acyl-acceptor binding pocket; other site
329726008926	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
329726008927	active site
329726008928	catalytic residues [active]
329726008929	metal binding site [ion binding]; metal-binding site
329726008930	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
329726008931	Bacterial sugar transferase; Region: Bac_transf; pfam02397
329726008932	Peptidase family M48; Region: Peptidase_M48; pfam01435
329726008933	Cyclic phosphodiesterase-like protein; Region: CPDase; pfam07823
329726008934	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
329726008935	spermidine synthase; Provisional; Region: PRK00811
329726008936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726008937	S-adenosylmethionine binding site [chemical binding]; other site
329726008938	agmatinase; Region: agmatinase; TIGR01230
329726008939	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
329726008940	putative active site [active]
329726008941	Mn binding site [ion binding]; other site
329726008942	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
329726008943	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
329726008944	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
329726008945	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
329726008946	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
329726008947	putative active site [active]
329726008948	catalytic site [active]
329726008949	Domon-like ligand-binding domains; Region: DOMON_like; cd00241
329726008950	putative ligand binding site [chemical binding]; other site
329726008951	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
329726008952	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
329726008953	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
329726008954	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
329726008955	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
329726008956	O-Antigen ligase; Region: Wzy_C; pfam04932
329726008957	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
329726008958	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
329726008959	VanW like protein; Region: VanW; pfam04294
329726008960	Transposase domain (DUF772); Region: DUF772; pfam05598
329726008961	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726008962	Stage II sporulation protein; Region: SpoIID; pfam08486
329726008963	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
329726008964	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
329726008965	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
329726008966	hydrophobic ligand binding site; other site
329726008967	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
329726008968	Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410
329726008969	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726008970	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726008971	S-adenosylmethionine binding site [chemical binding]; other site
329726008972	recombinase A; Provisional; Region: recA; PRK09354
329726008973	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
329726008974	hexamer interface [polypeptide binding]; other site
329726008975	Walker A motif; other site
329726008976	ATP binding site [chemical binding]; other site
329726008977	Walker B motif; other site
329726008978	PhoD-like phosphatase; Region: PhoD; pfam09423
329726008979	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
329726008980	putative active site [active]
329726008981	putative metal binding site [ion binding]; other site
329726008982	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
329726008983	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
329726008984	HSP70 interaction site [polypeptide binding]; other site
329726008985	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726008986	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726008987	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726008988	short chain dehydrogenase; Provisional; Region: PRK06197
329726008989	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
329726008990	putative NAD(P) binding site [chemical binding]; other site
329726008991	active site
329726008992	cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662
329726008993	flavonoid reductase (FR), extended (e) SDRs; Region: FR_SDR_e; cd08958
329726008994	NADP binding site [chemical binding]; other site
329726008995	substrate binding site [chemical binding]; other site
329726008996	active site
329726008997	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726008998	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
329726008999	non-specific DNA binding site [nucleotide binding]; other site
329726009000	salt bridge; other site
329726009001	sequence-specific DNA binding site [nucleotide binding]; other site
329726009002	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
329726009003	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
329726009004	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
329726009005	Cytochrome P450; Region: p450; cl12078
329726009006	Lipoxygenase; Region: Lipoxygenase; pfam00305
329726009007	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726009008	active site
329726009009	ATP binding site [chemical binding]; other site
329726009010	substrate binding site [chemical binding]; other site
329726009011	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726009012	activation loop (A-loop); other site
329726009013	AAA ATPase domain; Region: AAA_16; pfam13191
329726009014	Predicted ATPase [General function prediction only]; Region: COG3899
329726009015	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726009016	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726009017	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726009018	dimer interface [polypeptide binding]; other site
329726009019	phosphorylation site [posttranslational modification]
329726009020	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726009021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726009022	ATP binding site [chemical binding]; other site
329726009023	Mg2+ binding site [ion binding]; other site
329726009024	G-X-G motif; other site
329726009025	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726009026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009027	active site
329726009028	phosphorylation site [posttranslational modification]
329726009029	intermolecular recognition site; other site
329726009030	dimerization interface [polypeptide binding]; other site
329726009031	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726009032	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009033	active site
329726009034	phosphorylation site [posttranslational modification]
329726009035	intermolecular recognition site; other site
329726009036	dimerization interface [polypeptide binding]; other site
329726009037	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726009038	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726009039	dimer interface [polypeptide binding]; other site
329726009040	phosphorylation site [posttranslational modification]
329726009041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726009042	ATP binding site [chemical binding]; other site
329726009043	Mg2+ binding site [ion binding]; other site
329726009044	G-X-G motif; other site
329726009045	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726009046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009047	active site
329726009048	phosphorylation site [posttranslational modification]
329726009049	intermolecular recognition site; other site
329726009050	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726009051	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726009052	metal binding site [ion binding]; metal-binding site
329726009053	active site
329726009054	I-site; other site
329726009055	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726009056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009057	active site
329726009058	phosphorylation site [posttranslational modification]
329726009059	intermolecular recognition site; other site
329726009060	dimerization interface [polypeptide binding]; other site
329726009061	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726009062	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726009063	metal binding site [ion binding]; metal-binding site
329726009064	active site
329726009065	I-site; other site
329726009066	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
329726009067	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
329726009068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
329726009069	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
329726009070	E3 interaction surface; other site
329726009071	lipoyl attachment site [posttranslational modification]; other site
329726009072	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
329726009073	e3 binding domain; Region: E3_binding; pfam02817
329726009074	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
329726009075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
329726009076	FIST N domain; Region: FIST; pfam08495
329726009077	FIST C domain; Region: FIST_C; pfam10442
329726009078	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
329726009079	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
329726009080	trimerization site [polypeptide binding]; other site
329726009081	active site
329726009082	Protein of function (DUF2518); Region: DUF2518; pfam10726
329726009083	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
329726009084	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
329726009085	putative active site [active]
329726009086	metal binding site [ion binding]; metal-binding site
329726009087	aspartate aminotransferase; Provisional; Region: PRK05942
329726009088	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
329726009089	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726009090	homodimer interface [polypeptide binding]; other site
329726009091	catalytic residue [active]
329726009092	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
329726009093	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
329726009094	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
329726009095	TrkA-N domain; Region: TrkA_N; pfam02254
329726009096	TrkA-C domain; Region: TrkA_C; pfam02080
329726009097	GTPase Era; Reviewed; Region: era; PRK00089
329726009098	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
329726009099	G1 box; other site
329726009100	GTP/Mg2+ binding site [chemical binding]; other site
329726009101	Switch I region; other site
329726009102	G2 box; other site
329726009103	Switch II region; other site
329726009104	G3 box; other site
329726009105	G4 box; other site
329726009106	G5 box; other site
329726009107	KH domain; Region: KH_2; pfam07650
329726009108	G-X-X-G motif; other site
329726009109	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
329726009110	dihydroorotase; Provisional; Region: PRK07369
329726009111	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
329726009112	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
329726009113	active site
329726009114	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
329726009115	catalytic core [active]
329726009116	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
329726009117	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
329726009118	catalytic core [active]
329726009119	CAAX protease self-immunity; Region: Abi; pfam02517
329726009120	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
329726009121	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
329726009122	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
329726009123	Predicted GTPase [General function prediction only]; Region: COG3596
329726009124	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
329726009125	G1 box; other site
329726009126	GTP/Mg2+ binding site [chemical binding]; other site
329726009127	G2 box; other site
329726009128	Switch I region; other site
329726009129	G3 box; other site
329726009130	Switch II region; other site
329726009131	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
329726009132	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
329726009133	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
329726009134	NAD binding site [chemical binding]; other site
329726009135	dimerization interface [polypeptide binding]; other site
329726009136	product binding site; other site
329726009137	substrate binding site [chemical binding]; other site
329726009138	zinc binding site [ion binding]; other site
329726009139	catalytic residues [active]
329726009140	ribosomal protein S20; Region: rps20; CHL00102
329726009141	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
329726009142	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
329726009143	active site
329726009144	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
329726009145	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
329726009146	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
329726009147	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
329726009148	RPB1 interaction site [polypeptide binding]; other site
329726009149	RPB10 interaction site [polypeptide binding]; other site
329726009150	RPB11 interaction site [polypeptide binding]; other site
329726009151	RPB3 interaction site [polypeptide binding]; other site
329726009152	RPB12 interaction site [polypeptide binding]; other site
329726009153	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
329726009154	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
329726009155	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
329726009156	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
329726009157	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
329726009158	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
329726009159	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
329726009160	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
329726009161	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
329726009162	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
329726009163	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
329726009164	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
329726009165	DNA binding site [nucleotide binding]
329726009166	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
329726009167	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
329726009168	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
329726009169	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149
329726009170	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
329726009171	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
329726009172	ThiS interaction site; other site
329726009173	putative active site [active]
329726009174	tetramer interface [polypeptide binding]; other site
329726009175	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
329726009176	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726009177	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726009178	DNA binding residues [nucleotide binding]
329726009179	Putative zinc-finger; Region: zf-HC2; pfam13490
329726009180	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
329726009181	UbiA prenyltransferase family; Region: UbiA; pfam01040
329726009182	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
329726009183	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726009184	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726009185	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
329726009186	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726009187	NAD(P) binding site [chemical binding]; other site
329726009188	active site
329726009189	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726009190	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726009191	S-adenosylmethionine binding site [chemical binding]; other site
329726009192	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726009193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726009194	S-adenosylmethionine binding site [chemical binding]; other site
329726009195	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
329726009196	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931
329726009197	putative active site [active]
329726009198	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
329726009199	Acid Phosphatase; Region: Acid_PPase; cl17256
329726009200	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669
329726009201	active site
329726009202	metal binding site [ion binding]; metal-binding site
329726009203	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726009204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726009205	S-adenosylmethionine binding site [chemical binding]; other site
329726009206	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051
329726009207	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
329726009208	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
329726009209	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
329726009210	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
329726009211	inhibitor-cofactor binding pocket; inhibition site
329726009212	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726009213	catalytic residue [active]
329726009214	putative trimer interface [polypeptide binding]; other site
329726009215	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
329726009216	putative CoA binding site [chemical binding]; other site
329726009217	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
329726009218	putative trimer interface [polypeptide binding]; other site
329726009219	putative active site [active]
329726009220	putative substrate binding site [chemical binding]; other site
329726009221	putative CoA binding site [chemical binding]; other site
329726009222	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
329726009223	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
329726009224	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
329726009225	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
329726009226	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
329726009227	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
329726009228	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
329726009229	NAD(P) binding site [chemical binding]; other site
329726009230	homodimer interface [polypeptide binding]; other site
329726009231	substrate binding site [chemical binding]; other site
329726009232	active site
329726009233	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
329726009234	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726009235	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
329726009236	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
329726009237	ribosomal protein L21; Region: rpl21; CHL00075
329726009238	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
329726009239	Oligomerisation domain; Region: Oligomerisation; pfam02410
329726009240	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
329726009241	Zn2+ binding site [ion binding]; other site
329726009242	Mg2+ binding site [ion binding]; other site
329726009243	Circadian oscillating protein COP23; Region: COP23; pfam14218
329726009244	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
329726009245	Fatty acid desaturase; Region: FA_desaturase; pfam00487
329726009246	putative di-iron ligands [ion binding]; other site
329726009247	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
329726009248	Domain of unknown function DUF20; Region: UPF0118; pfam01594
329726009249	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
329726009250	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
329726009251	putative NAD(P) binding site [chemical binding]; other site
329726009252	Late competence development protein ComFB; Region: ComFB; pfam10719
329726009253	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
329726009254	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
329726009255	active site
329726009256	catalytic residues [active]
329726009257	metal binding site [ion binding]; metal-binding site
329726009258	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
329726009259	Peptidase family M50; Region: Peptidase_M50; pfam02163
329726009260	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
329726009261	active site
329726009262	putative substrate binding region [chemical binding]; other site
329726009263	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
329726009264	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726009265	active site
329726009266	ATP binding site [chemical binding]; other site
329726009267	substrate binding site [chemical binding]; other site
329726009268	activation loop (A-loop); other site
329726009269	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
329726009270	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
329726009271	homodimer interface [polypeptide binding]; other site
329726009272	substrate-cofactor binding pocket; other site
329726009273	catalytic residue [active]
329726009274	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
329726009275	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
329726009276	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
329726009277	active site
329726009278	homodimer interface [polypeptide binding]; other site
329726009279	catalytic site [active]
329726009280	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
329726009281	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726009282	active site
329726009283	motif I; other site
329726009284	motif II; other site
329726009285	Uncharacterized conserved protein [Function unknown]; Region: COG0398
329726009286	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
329726009287	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
329726009288	lipoprotein signal peptidase; Provisional; Region: PRK14787
329726009289	BioY family; Region: BioY; pfam02632
329726009290	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
329726009291	Photosystem II protein; Region: PSII; cl08223
329726009292	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
329726009293	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
329726009294	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
329726009295	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
329726009296	FMN binding site [chemical binding]; other site
329726009297	active site
329726009298	catalytic residues [active]
329726009299	substrate binding site [chemical binding]; other site
329726009300	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
329726009301	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
329726009302	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
329726009303	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
329726009304	DNA polymerase III subunit delta; Validated; Region: PRK07452
329726009305	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
329726009306	precorrin-8X methylmutase; Provisional; Region: PRK05954
329726009307	Precorrin-8X methylmutase; Region: CbiC; pfam02570
329726009308	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
329726009309	active site
329726009310	putative homodimer interface [polypeptide binding]; other site
329726009311	SAM binding site [chemical binding]; other site
329726009312	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
329726009313	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
329726009314	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726009315	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
329726009316	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726009317	catalytic loop [active]
329726009318	iron binding site [ion binding]; other site
329726009319	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
329726009320	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
329726009321	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
329726009322	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
329726009323	active site lid residues [active]
329726009324	substrate binding pocket [chemical binding]; other site
329726009325	catalytic residues [active]
329726009326	substrate-Mg2+ binding site; other site
329726009327	aspartate-rich region 1; other site
329726009328	aspartate-rich region 2; other site
329726009329	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
329726009330	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
329726009331	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
329726009332	active site
329726009333	putative lithium-binding site [ion binding]; other site
329726009334	substrate binding site [chemical binding]; other site
329726009335	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
329726009336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726009337	S-adenosylmethionine binding site [chemical binding]; other site
329726009338	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
329726009339	short chain dehydrogenase; Provisional; Region: PRK05693
329726009340	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
329726009341	NADP binding site [chemical binding]; other site
329726009342	active site
329726009343	steroid binding site; other site
329726009344	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
329726009345	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726009346	Coenzyme A binding pocket [chemical binding]; other site
329726009347	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726009348	metal binding site 2 [ion binding]; metal-binding site
329726009349	putative DNA binding helix; other site
329726009350	metal binding site 1 [ion binding]; metal-binding site
329726009351	dimer interface [polypeptide binding]; other site
329726009352	structural Zn2+ binding site [ion binding]; other site
329726009353	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
329726009354	catalytic triad [active]
329726009355	dimer interface [polypeptide binding]; other site
329726009356	glutathione reductase; Validated; Region: PRK06116
329726009357	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
329726009358	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
329726009359	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
329726009360	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
329726009361	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
329726009362	iron-sulfur cluster [ion binding]; other site
329726009363	[2Fe-2S] cluster binding site [ion binding]; other site
329726009364	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
329726009365	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
329726009366	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726009367	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
329726009368	Phage Tail Collar Domain; Region: Collar; pfam07484
329726009369	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
329726009370	Phage Tail Collar Domain; Region: Collar; pfam07484
329726009371	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
329726009372	Phage Tail Collar Domain; Region: Collar; pfam07484
329726009373	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
329726009374	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
329726009375	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726009376	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
329726009377	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
329726009378	putative hydrophobic ligand binding site [chemical binding]; other site
329726009379	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726009380	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726009381	Transposase, Mutator family; Region: Transposase_mut; pfam00872
329726009382	MULE transposase domain; Region: MULE; pfam10551
329726009383	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
329726009384	Transposase; Region: HTH_Tnp_1; pfam01527
329726009385	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
329726009386	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726009387	putative active site [active]
329726009388	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726009389	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726009390	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726009391	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726009392	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
329726009393	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
329726009394	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
329726009395	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
329726009396	active site
329726009397	metal binding site [ion binding]; metal-binding site
329726009398	hexamer interface [polypeptide binding]; other site
329726009399	AAA ATPase domain; Region: AAA_16; pfam13191
329726009400	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726009401	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726009402	TPR motif; other site
329726009403	binding surface
329726009404	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
329726009405	This domain is found in peptide chain release factors; Region: PCRF; smart00937
329726009406	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
329726009407	RF-1 domain; Region: RF-1; pfam00472
329726009408	E3 Ubiquitin ligase; Region: GIDE; pfam12483
329726009409	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726009410	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726009411	metal binding site [ion binding]; metal-binding site
329726009412	active site
329726009413	I-site; other site
329726009414	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
329726009415	Predicted acetyltransferase [General function prediction only]; Region: COG3393
329726009416	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726009417	Coenzyme A binding pocket [chemical binding]; other site
329726009418	ferric uptake regulator; Provisional; Region: fur; PRK09462
329726009419	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726009420	metal binding site 2 [ion binding]; metal-binding site
329726009421	putative DNA binding helix; other site
329726009422	metal binding site 1 [ion binding]; metal-binding site
329726009423	dimer interface [polypeptide binding]; other site
329726009424	structural Zn2+ binding site [ion binding]; other site
329726009425	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
329726009426	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
329726009427	dimer interface [polypeptide binding]; other site
329726009428	active site
329726009429	heme binding site [chemical binding]; other site
329726009430	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
329726009431	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726009432	Ligand Binding Site [chemical binding]; other site
329726009433	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726009434	Ligand Binding Site [chemical binding]; other site
329726009435	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
329726009436	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
329726009437	Sulfate transporter family; Region: Sulfate_transp; pfam00916
329726009438	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
329726009439	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
329726009440	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
329726009441	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
329726009442	Walker A/P-loop; other site
329726009443	ATP binding site [chemical binding]; other site
329726009444	Q-loop/lid; other site
329726009445	ABC transporter signature motif; other site
329726009446	Walker B; other site
329726009447	D-loop; other site
329726009448	H-loop/switch region; other site
329726009449	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
329726009450	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
329726009451	active site
329726009452	metal binding site [ion binding]; metal-binding site
329726009453	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
329726009454	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
329726009455	Walker A/P-loop; other site
329726009456	ATP binding site [chemical binding]; other site
329726009457	Q-loop/lid; other site
329726009458	ABC transporter signature motif; other site
329726009459	Walker B; other site
329726009460	D-loop; other site
329726009461	H-loop/switch region; other site
329726009462	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726009463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009464	active site
329726009465	phosphorylation site [posttranslational modification]
329726009466	intermolecular recognition site; other site
329726009467	dimerization interface [polypeptide binding]; other site
329726009468	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726009469	DNA binding site [nucleotide binding]
329726009470	Integral membrane protein TerC family; Region: TerC; cl10468
329726009471	NAD-dependent deacetylase; Provisional; Region: PRK00481
329726009472	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
329726009473	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
329726009474	active site
329726009475	multimer interface [polypeptide binding]; other site
329726009476	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
329726009477	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
329726009478	active site
329726009479	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
329726009480	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726009481	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726009482	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726009483	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726009484	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726009485	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726009486	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726009487	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726009488	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
329726009489	putative binding surface; other site
329726009490	active site
329726009491	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
329726009492	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
329726009493	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726009494	ATP binding site [chemical binding]; other site
329726009495	Mg2+ binding site [ion binding]; other site
329726009496	G-X-G motif; other site
329726009497	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
329726009498	Response regulator receiver domain; Region: Response_reg; pfam00072
329726009499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009500	active site
329726009501	phosphorylation site [posttranslational modification]
329726009502	intermolecular recognition site; other site
329726009503	dimerization interface [polypeptide binding]; other site
329726009504	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726009505	dimerization interface [polypeptide binding]; other site
329726009506	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
329726009507	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
329726009508	dimer interface [polypeptide binding]; other site
329726009509	putative CheW interface [polypeptide binding]; other site
329726009510	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
329726009511	Response regulator receiver domain; Region: Response_reg; pfam00072
329726009512	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009513	active site
329726009514	phosphorylation site [posttranslational modification]
329726009515	intermolecular recognition site; other site
329726009516	dimerization interface [polypeptide binding]; other site
329726009517	Response regulator receiver domain; Region: Response_reg; pfam00072
329726009518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009519	active site
329726009520	phosphorylation site [posttranslational modification]
329726009521	intermolecular recognition site; other site
329726009522	dimerization interface [polypeptide binding]; other site
329726009523	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
329726009524	putative active site [active]
329726009525	Zn binding site [ion binding]; other site
329726009526	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
329726009527	Dimer interface [polypeptide binding]; other site
329726009528	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
329726009529	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
329726009530	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726009531	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726009532	active site
329726009533	ATP binding site [chemical binding]; other site
329726009534	substrate binding site [chemical binding]; other site
329726009535	activation loop (A-loop); other site
329726009536	Bacterial SH3 domain homologues; Region: SH3b; smart00287
329726009537	O-succinylbenzoate synthase; Provisional; Region: PRK02714
329726009538	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
329726009539	active site
329726009540	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
329726009541	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
329726009542	acyl-activating enzyme (AAE) consensus motif; other site
329726009543	putative AMP binding site [chemical binding]; other site
329726009544	putative active site [active]
329726009545	putative CoA binding site [chemical binding]; other site
329726009546	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
329726009547	phosphoglycolate phosphatase; Provisional; Region: PRK01158
329726009548	TM2 domain; Region: TM2; cl00984
329726009549	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726009550	non-specific DNA binding site [nucleotide binding]; other site
329726009551	salt bridge; other site
329726009552	sequence-specific DNA binding site [nucleotide binding]; other site
329726009553	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
329726009554	Domain of unknown function (DUF3474); Region: DUF3474; pfam11960
329726009555	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
329726009556	putative di-iron ligands [ion binding]; other site
329726009557	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
329726009558	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
329726009559	AAA domain; Region: AAA_33; pfam13671
329726009560	tRNAHis guanylyltransferase; Region: Thg1; pfam04446
329726009561	Thg1 C terminal domain; Region: Thg1C; pfam14413
329726009562	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
329726009563	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726009564	active site
329726009565	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
329726009566	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
329726009567	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
329726009568	trimer interface [polypeptide binding]; other site
329726009569	putative metal binding site [ion binding]; other site
329726009570	Photosystem II protein Y (PsbY); Region: PsbY; pfam06298
329726009571	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
329726009572	Short C-terminal domain; Region: SHOCT; pfam09851
329726009573	lipoyl synthase; Provisional; Region: PRK05481
329726009574	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
329726009575	FeS/SAM binding site; other site
329726009576	ribonuclease E; Reviewed; Region: rne; PRK10811
329726009577	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
329726009578	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
329726009579	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726009580	Walker A/P-loop; other site
329726009581	ATP binding site [chemical binding]; other site
329726009582	Q-loop/lid; other site
329726009583	ABC transporter signature motif; other site
329726009584	Walker B; other site
329726009585	D-loop; other site
329726009586	H-loop/switch region; other site
329726009587	S-layer homology domain; Region: SLH; pfam00395
329726009588	S-layer homology domain; Region: SLH; pfam00395
329726009589	Uncharacterized conserved protein [Function unknown]; Region: COG1565
329726009590	TPR repeat; Region: TPR_11; pfam13414
329726009591	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726009592	binding surface
329726009593	TPR motif; other site
329726009594	Tetratricopeptide repeat; Region: TPR_16; pfam13432
329726009595	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726009596	binding surface
329726009597	TPR motif; other site
329726009598	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726009599	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726009600	binding surface
329726009601	TPR motif; other site
329726009602	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726009603	TPR motif; other site
329726009604	binding surface
329726009605	TPR repeat; Region: TPR_11; pfam13414
329726009606	TPR repeat; Region: TPR_11; pfam13414
329726009607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726009608	binding surface
329726009609	TPR motif; other site
329726009610	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726009611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726009612	binding surface
329726009613	TPR motif; other site
329726009614	TPR repeat; Region: TPR_11; pfam13414
329726009615	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726009616	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726009617	transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634
329726009618	putative RNA binding site [nucleotide binding]; other site
329726009619	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
329726009620	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
329726009621	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
329726009622	P loop; other site
329726009623	GTP binding site [chemical binding]; other site
329726009624	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
329726009625	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
329726009626	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
329726009627	proline aminopeptidase P II; Provisional; Region: PRK10879
329726009628	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
329726009629	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
329726009630	active site
329726009631	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
329726009632	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
329726009633	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
329726009634	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
329726009635	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
329726009636	Zn binding site [ion binding]; other site
329726009637	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
329726009638	photosystem II protein I; Region: psbI; CHL00024
329726009639	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
329726009640	Uncharacterized conserved protein [Function unknown]; Region: COG0432
329726009641	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
329726009642	Transmembrane proteins 14C; Region: Tmemb_14; pfam03647
329726009643	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726009644	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726009645	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
329726009646	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
329726009647	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
329726009648	homodimer interface [polypeptide binding]; other site
329726009649	substrate-cofactor binding pocket; other site
329726009650	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726009651	catalytic residue [active]
329726009652	Protein of unknown function (DUF4241); Region: DUF4241; pfam14025
329726009653	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
329726009654	putative active site [active]
329726009655	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
329726009656	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
329726009657	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
329726009658	catalytic residues [active]
329726009659	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
329726009660	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
329726009661	nucleotide binding site [chemical binding]; other site
329726009662	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
329726009663	Beta-lactamase; Region: Beta-lactamase; pfam00144
329726009664	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
329726009665	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726009666	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
329726009667	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726009668	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726009669	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
329726009670	MPT binding site; other site
329726009671	trimer interface [polypeptide binding]; other site
329726009672	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
329726009673	active site
329726009674	metal binding site [ion binding]; metal-binding site
329726009675	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
329726009676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726009677	S-adenosylmethionine binding site [chemical binding]; other site
329726009678	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
329726009679	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726009680	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726009681	AAA ATPase domain; Region: AAA_16; pfam13191
329726009682	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726009683	structural tetrad; other site
329726009684	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726009685	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726009686	structural tetrad; other site
329726009687	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
329726009688	catalytic motif [active]
329726009689	Catalytic residue [active]
329726009690	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
329726009691	NADPH bind site [chemical binding]; other site
329726009692	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
329726009693	putative FMN binding site [chemical binding]; other site
329726009694	NADPH bind site [chemical binding]; other site
329726009695	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
329726009696	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726009697	motif II; other site
329726009698	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
329726009699	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
329726009700	5-oxoprolinase; Region: PLN02666
329726009701	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
329726009702	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
329726009703	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
329726009704	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
329726009705	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
329726009706	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
329726009707	TrkA-N domain; Region: TrkA_N; pfam02254
329726009708	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
329726009709	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
329726009710	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726009711	motif II; other site
329726009712	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
329726009713	dimerization interface [polypeptide binding]; other site
329726009714	putative active cleft [active]
329726009715	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726009716	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726009717	DNA binding residues [nucleotide binding]
329726009718	dimerization interface [polypeptide binding]; other site
329726009719	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
329726009720	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
329726009721	G1 box; other site
329726009722	putative GEF interaction site [polypeptide binding]; other site
329726009723	GTP/Mg2+ binding site [chemical binding]; other site
329726009724	Switch I region; other site
329726009725	G2 box; other site
329726009726	G3 box; other site
329726009727	Switch II region; other site
329726009728	G4 box; other site
329726009729	G5 box; other site
329726009730	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
329726009731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009732	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726009733	active site
329726009734	phosphorylation site [posttranslational modification]
329726009735	intermolecular recognition site; other site
329726009736	dimerization interface [polypeptide binding]; other site
329726009737	TIGR03943 family protein; Region: TIGR03943
329726009738	Predicted permeases [General function prediction only]; Region: COG0701
329726009739	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
329726009740	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
329726009741	photosystem II protein K; Region: psbK; CHL00047
329726009742	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
329726009743	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
329726009744	catalytic motif [active]
329726009745	Zn binding site [ion binding]; other site
329726009746	RibD C-terminal domain; Region: RibD_C; cl17279
329726009747	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
329726009748	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
329726009749	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
329726009750	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
329726009751	putative acyl-acceptor binding pocket; other site
329726009752	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
329726009753	Acyltransferase family; Region: Acyl_transf_3; pfam01757
329726009754	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
329726009755	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726009756	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
329726009757	putative transposase OrfB; Reviewed; Region: PHA02517
329726009758	HTH-like domain; Region: HTH_21; pfam13276
329726009759	Integrase core domain; Region: rve; pfam00665
329726009760	Integrase core domain; Region: rve_3; pfam13683
329726009761	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
329726009762	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726009763	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726009764	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726009765	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726009766	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726009767	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726009768	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726009769	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726009770	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726009771	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726009772	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726009773	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726009774	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726009775	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
329726009776	ATP binding site [chemical binding]; other site
329726009777	putative Mg++ binding site [ion binding]; other site
329726009778	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726009779	nucleotide binding region [chemical binding]; other site
329726009780	ATP-binding site [chemical binding]; other site
329726009781	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726009782	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726009783	putative active site [active]
329726009784	heme pocket [chemical binding]; other site
329726009785	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726009786	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726009787	putative active site [active]
329726009788	heme pocket [chemical binding]; other site
329726009789	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726009790	putative active site [active]
329726009791	heme pocket [chemical binding]; other site
329726009792	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726009793	dimer interface [polypeptide binding]; other site
329726009794	phosphorylation site [posttranslational modification]
329726009795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726009796	ATP binding site [chemical binding]; other site
329726009797	Mg2+ binding site [ion binding]; other site
329726009798	G-X-G motif; other site
329726009799	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726009800	PAS fold; Region: PAS_3; pfam08447
329726009801	putative active site [active]
329726009802	heme pocket [chemical binding]; other site
329726009803	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
329726009804	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726009805	dimer interface [polypeptide binding]; other site
329726009806	phosphorylation site [posttranslational modification]
329726009807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726009808	ATP binding site [chemical binding]; other site
329726009809	Mg2+ binding site [ion binding]; other site
329726009810	G-X-G motif; other site
329726009811	Response regulator receiver domain; Region: Response_reg; pfam00072
329726009812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009813	active site
329726009814	phosphorylation site [posttranslational modification]
329726009815	intermolecular recognition site; other site
329726009816	dimerization interface [polypeptide binding]; other site
329726009817	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726009818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009819	active site
329726009820	phosphorylation site [posttranslational modification]
329726009821	intermolecular recognition site; other site
329726009822	dimerization interface [polypeptide binding]; other site
329726009823	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726009824	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726009825	metal binding site [ion binding]; metal-binding site
329726009826	active site
329726009827	I-site; other site
329726009828	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726009829	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
329726009830	HSP70 interaction site [polypeptide binding]; other site
329726009831	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726009832	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726009833	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726009834	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726009835	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726009836	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
329726009837	putative hexamer interface [polypeptide binding]; other site
329726009838	putative hexagonal pore; other site
329726009839	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
329726009840	Hexamer interface [polypeptide binding]; other site
329726009841	Hexagonal pore residue; other site
329726009842	flavoprotein, HI0933 family; Region: TIGR00275
329726009843	ferredoxin-sulfite reductase; Region: sir; TIGR02042
329726009844	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
329726009845	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
329726009846	ParG; Region: ParG; pfam09274
329726009847	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
329726009848	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
329726009849	cytochrome c-550; Provisional; Region: psbV; cl17239
329726009850	cytochrome c-550; Provisional; Region: psbV; PRK13621
329726009851	cytochrome c-550; Provisional; Region: psbV; PRK13621
329726009852	cytochrome c-550; Provisional; Region: psbV; cl17239
329726009853	Cytochrome c; Region: Cytochrom_C; cl11414
329726009854	Protein of unknown function, DUF399; Region: DUF399; pfam04187
329726009855	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
329726009856	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
329726009857	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
329726009858	NADP binding site [chemical binding]; other site
329726009859	substrate binding site [chemical binding]; other site
329726009860	active site
329726009861	RNA binding activity-knot of a chromodomain; Region: Tudor-knot; pfam11717
329726009862	Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; Region: TUDOR; cl02573
329726009863	N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867
329726009864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726009865	S-adenosylmethionine binding site [chemical binding]; other site
329726009866	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
329726009867	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
329726009868	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
329726009869	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
329726009870	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
329726009871	nucleotide binding site/active site [active]
329726009872	HIT family signature motif; other site
329726009873	catalytic residue [active]
329726009874	ATP adenylyltransferase; Region: ATP_transf; pfam09830
329726009875	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726009876	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726009877	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726009878	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726009879	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726009880	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726009881	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726009882	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
329726009883	Circadian oscillating protein COP23; Region: COP23; pfam14218
329726009884	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726009885	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726009886	TPR motif; other site
329726009887	TPR repeat; Region: TPR_11; pfam13414
329726009888	binding surface
329726009889	TPR repeat; Region: TPR_11; pfam13414
329726009890	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726009891	binding surface
329726009892	TPR motif; other site
329726009893	TPR repeat; Region: TPR_11; pfam13414
329726009894	Lipoxygenase; Region: Lipoxygenase; pfam00305
329726009895	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
329726009896	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
329726009897	Malic enzyme, N-terminal domain; Region: malic; pfam00390
329726009898	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
329726009899	putative NAD(P) binding site [chemical binding]; other site
329726009900	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
329726009901	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
329726009902	HIGH motif; other site
329726009903	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
329726009904	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
329726009905	active site
329726009906	KMSKS motif; other site
329726009907	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
329726009908	tRNA binding surface [nucleotide binding]; other site
329726009909	anticodon binding site; other site
329726009910	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
329726009911	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
329726009912	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726009913	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
329726009914	CHAT domain; Region: CHAT; cl17868
329726009915	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
329726009916	Circadian oscillating protein COP23; Region: COP23; pfam14218
329726009917	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726009918	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726009919	active site
329726009920	ATP binding site [chemical binding]; other site
329726009921	substrate binding site [chemical binding]; other site
329726009922	activation loop (A-loop); other site
329726009923	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726009924	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726009925	catalytic loop [active]
329726009926	iron binding site [ion binding]; other site
329726009927	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
329726009928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009929	active site
329726009930	phosphorylation site [posttranslational modification]
329726009931	intermolecular recognition site; other site
329726009932	recombination protein RecR; Reviewed; Region: recR; PRK00076
329726009933	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
329726009934	RecR protein; Region: RecR; pfam02132
329726009935	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
329726009936	putative active site [active]
329726009937	putative metal-binding site [ion binding]; other site
329726009938	tetramer interface [polypeptide binding]; other site
329726009939	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
329726009940	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
329726009941	minor groove reading motif; other site
329726009942	helix-hairpin-helix signature motif; other site
329726009943	substrate binding pocket [chemical binding]; other site
329726009944	active site
329726009945	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
329726009946	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
329726009947	active site
329726009948	8-oxo-dGMP binding site [chemical binding]; other site
329726009949	nudix motif; other site
329726009950	metal binding site [ion binding]; metal-binding site
329726009951	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726009952	S-adenosylmethionine binding site [chemical binding]; other site
329726009953	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726009954	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726009955	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726009956	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
329726009957	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726009958	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726009959	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726009960	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726009961	DNA binding residues [nucleotide binding]
329726009962	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
329726009963	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
329726009964	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
329726009965	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
329726009966	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726009967	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726009968	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726009969	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
329726009970	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
329726009971	carboxyltransferase (CT) interaction site; other site
329726009972	biotinylation site [posttranslational modification]; other site
329726009973	elongation factor P; Validated; Region: PRK00529
329726009974	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
329726009975	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
329726009976	RNA binding site [nucleotide binding]; other site
329726009977	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
329726009978	RNA binding site [nucleotide binding]; other site
329726009979	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726009980	PAS fold; Region: PAS_3; pfam08447
329726009981	putative active site [active]
329726009982	heme pocket [chemical binding]; other site
329726009983	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726009984	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726009985	metal binding site [ion binding]; metal-binding site
329726009986	active site
329726009987	I-site; other site
329726009988	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726009989	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726009990	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726009991	phosphopeptide binding site; other site
329726009992	Response regulator receiver domain; Region: Response_reg; pfam00072
329726009993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726009994	active site
329726009995	phosphorylation site [posttranslational modification]
329726009996	intermolecular recognition site; other site
329726009997	dimerization interface [polypeptide binding]; other site
329726009998	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726009999	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726010000	ATP binding site [chemical binding]; other site
329726010001	Mg2+ binding site [ion binding]; other site
329726010002	G-X-G motif; other site
329726010003	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
329726010004	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
329726010005	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
329726010006	homotetramer interface [polypeptide binding]; other site
329726010007	ligand binding site [chemical binding]; other site
329726010008	catalytic site [active]
329726010009	NAD binding site [chemical binding]; other site
329726010010	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010011	TPR motif; other site
329726010012	TPR repeat; Region: TPR_11; pfam13414
329726010013	binding surface
329726010014	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
329726010015	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
329726010016	putative substrate binding site [chemical binding]; other site
329726010017	putative ATP binding site [chemical binding]; other site
329726010018	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
329726010019	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
329726010020	domain interfaces; other site
329726010021	active site
329726010022	TPR repeat; Region: TPR_11; pfam13414
329726010023	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010024	binding surface
329726010025	TPR motif; other site
329726010026	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726010027	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010028	binding surface
329726010029	TPR motif; other site
329726010030	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
329726010031	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010032	binding surface
329726010033	TPR motif; other site
329726010034	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
329726010035	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
329726010036	putative NAD(P) binding site [chemical binding]; other site
329726010037	active site
329726010038	6-phosphofructokinase; Provisional; Region: PRK14071
329726010039	active site
329726010040	ADP/pyrophosphate binding site [chemical binding]; other site
329726010041	dimerization interface [polypeptide binding]; other site
329726010042	allosteric effector site; other site
329726010043	fructose-1,6-bisphosphate binding site; other site
329726010044	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
329726010045	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
329726010046	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
329726010047	Catalytic site [active]
329726010048	AAA ATPase domain; Region: AAA_16; pfam13191
329726010049	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726010050	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726010051	active site
329726010052	ATP binding site [chemical binding]; other site
329726010053	substrate binding site [chemical binding]; other site
329726010054	activation loop (A-loop); other site
329726010055	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
329726010056	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
329726010057	hypothetical protein; Reviewed; Region: PRK12497
329726010058	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726010059	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726010060	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726010061	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726010062	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
329726010063	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
329726010064	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726010065	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726010066	catalytic loop [active]
329726010067	iron binding site [ion binding]; other site
329726010068	YwiC-like protein; Region: YwiC; pfam14256
329726010069	ScpA/B protein; Region: ScpA_ScpB; pfam02616
329726010070	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
329726010071	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
329726010072	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
329726010073	RNA binding surface [nucleotide binding]; other site
329726010074	L-aspartate oxidase; Provisional; Region: PRK07395
329726010075	L-aspartate oxidase; Provisional; Region: PRK06175
329726010076	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
329726010077	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
329726010078	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726010079	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726010080	phosphopeptide binding site; other site
329726010081	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
329726010082	cyclase homology domain; Region: CHD; cd07302
329726010083	nucleotidyl binding site; other site
329726010084	metal binding site [ion binding]; metal-binding site
329726010085	dimer interface [polypeptide binding]; other site
329726010086	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
329726010087	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
329726010088	NADP binding site [chemical binding]; other site
329726010089	active site
329726010090	putative substrate binding site [chemical binding]; other site
329726010091	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
329726010092	RNA binding surface [nucleotide binding]; other site
329726010093	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
329726010094	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
329726010095	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
329726010096	Domain of unknown function (DUF4016); Region: DUF4016; pfam13208
329726010097	tellurite resistance protein terB; Region: terB; cd07176
329726010098	putative metal binding site [ion binding]; other site
329726010099	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
329726010100	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726010101	dimer interface [polypeptide binding]; other site
329726010102	conserved gate region; other site
329726010103	putative PBP binding loops; other site
329726010104	ABC-ATPase subunit interface; other site
329726010105	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
329726010106	heat shock protein HtpX; Provisional; Region: PRK03982
329726010107	enolase; Provisional; Region: eno; PRK00077
329726010108	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
329726010109	dimer interface [polypeptide binding]; other site
329726010110	metal binding site [ion binding]; metal-binding site
329726010111	substrate binding pocket [chemical binding]; other site
329726010112	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726010113	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
329726010114	dimer interface [polypeptide binding]; other site
329726010115	active site
329726010116	metal binding site [ion binding]; metal-binding site
329726010117	glutathione binding site [chemical binding]; other site
329726010118	S-layer homology domain; Region: SLH; pfam00395
329726010119	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
329726010120	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
329726010121	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726010122	FeS/SAM binding site; other site
329726010123	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
329726010124	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
329726010125	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
329726010126	RNA binding surface [nucleotide binding]; other site
329726010127	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
329726010128	substrate binding site; other site
329726010129	dimer interface; other site
329726010130	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
329726010131	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
329726010132	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726010133	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726010134	catalytic loop [active]
329726010135	iron binding site [ion binding]; other site
329726010136	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
329726010137	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
329726010138	active site
329726010139	dimerization interface [polypeptide binding]; other site
329726010140	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
329726010141	HSP70 interaction site [polypeptide binding]; other site
329726010142	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010143	binding surface
329726010144	TPR repeat; Region: TPR_11; pfam13414
329726010145	TPR motif; other site
329726010146	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
329726010147	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
329726010148	dimer interface [polypeptide binding]; other site
329726010149	motif 1; other site
329726010150	active site
329726010151	motif 2; other site
329726010152	motif 3; other site
329726010153	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
329726010154	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
329726010155	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726010156	phosphopeptide binding site; other site
329726010157	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
329726010158	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
329726010159	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
329726010160	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
329726010161	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
329726010162	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726010163	homodimer interface [polypeptide binding]; other site
329726010164	catalytic residue [active]
329726010165	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
329726010166	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
329726010167	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
329726010168	active site
329726010169	catalytic tetrad [active]
329726010170	citrate synthase; Provisional; Region: PRK14036
329726010171	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
329726010172	oxalacetate binding site [chemical binding]; other site
329726010173	citrylCoA binding site [chemical binding]; other site
329726010174	coenzyme A binding site [chemical binding]; other site
329726010175	catalytic triad [active]
329726010176	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
329726010177	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
329726010178	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
329726010179	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
329726010180	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
329726010181	putative active site [active]
329726010182	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726010183	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
329726010184	Walker A/P-loop; other site
329726010185	ATP binding site [chemical binding]; other site
329726010186	Q-loop/lid; other site
329726010187	ABC transporter signature motif; other site
329726010188	Walker B; other site
329726010189	D-loop; other site
329726010190	H-loop/switch region; other site
329726010191	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
329726010192	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
329726010193	E3 interaction surface; other site
329726010194	lipoyl attachment site [posttranslational modification]; other site
329726010195	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726010196	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
329726010197	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
329726010198	putative active site [active]
329726010199	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
329726010200	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726010201	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
329726010202	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726010203	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
329726010204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
329726010205	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
329726010206	Predicted permeases [General function prediction only]; Region: COG0795
329726010207	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
329726010208	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
329726010209	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
329726010210	Walker A/P-loop; other site
329726010211	ATP binding site [chemical binding]; other site
329726010212	Q-loop/lid; other site
329726010213	ABC transporter signature motif; other site
329726010214	Walker B; other site
329726010215	D-loop; other site
329726010216	H-loop/switch region; other site
329726010217	OstA-like protein; Region: OstA; cl00844
329726010218	Domain of unknown function (DUF309); Region: DUF309; pfam03745
329726010219	ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165
329726010220	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
329726010221	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
329726010222	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726010223	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726010224	active site
329726010225	ATP binding site [chemical binding]; other site
329726010226	substrate binding site [chemical binding]; other site
329726010227	activation loop (A-loop); other site
329726010228	Predicted transcriptional regulators [Transcription]; Region: COG1695
329726010229	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
329726010230	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
329726010231	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
329726010232	dinuclear metal binding motif [ion binding]; other site
329726010233	acyl-ACP reductase; Provisional; Region: PRK14982
329726010234	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
329726010235	NAD(P) binding pocket [chemical binding]; other site
329726010236	Predicted permeases [General function prediction only]; Region: COG0795
329726010237	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
329726010238	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
329726010239	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726010240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726010241	S-adenosylmethionine binding site [chemical binding]; other site
329726010242	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
329726010243	MAPEG family; Region: MAPEG; pfam01124
329726010244	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726010245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726010246	active site
329726010247	phosphorylation site [posttranslational modification]
329726010248	intermolecular recognition site; other site
329726010249	dimerization interface [polypeptide binding]; other site
329726010250	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726010251	DNA binding site [nucleotide binding]
329726010252	DEAD-like helicases superfamily; Region: DEXDc; smart00487
329726010253	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726010254	ATP binding site [chemical binding]; other site
329726010255	putative Mg++ binding site [ion binding]; other site
329726010256	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726010257	ATP-binding site [chemical binding]; other site
329726010258	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
329726010259	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
329726010260	putative binding surface; other site
329726010261	active site
329726010262	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
329726010263	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
329726010264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726010265	ATP binding site [chemical binding]; other site
329726010266	Mg2+ binding site [ion binding]; other site
329726010267	G-X-G motif; other site
329726010268	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
329726010269	Response regulator receiver domain; Region: Response_reg; pfam00072
329726010270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726010271	active site
329726010272	phosphorylation site [posttranslational modification]
329726010273	intermolecular recognition site; other site
329726010274	dimerization interface [polypeptide binding]; other site
329726010275	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010276	TPR motif; other site
329726010277	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726010278	dimerization interface [polypeptide binding]; other site
329726010279	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
329726010280	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
329726010281	dimer interface [polypeptide binding]; other site
329726010282	putative CheW interface [polypeptide binding]; other site
329726010283	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
329726010284	Response regulator receiver domain; Region: Response_reg; pfam00072
329726010285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726010286	active site
329726010287	phosphorylation site [posttranslational modification]
329726010288	intermolecular recognition site; other site
329726010289	dimerization interface [polypeptide binding]; other site
329726010290	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
329726010291	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
329726010292	Fe-S cluster binding site [ion binding]; other site
329726010293	active site
329726010294	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
329726010295	GIY-YIG motif/motif A; other site
329726010296	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726010297	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
329726010298	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
329726010299	active site
329726010300	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
329726010301	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
329726010302	putative substrate binding region [chemical binding]; other site
329726010303	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
329726010304	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
329726010305	minor groove reading motif; other site
329726010306	helix-hairpin-helix signature motif; other site
329726010307	substrate binding pocket [chemical binding]; other site
329726010308	active site
329726010309	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
329726010310	ribosomal protein S14; Region: rps14; CHL00074
329726010311	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
329726010312	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
329726010313	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
329726010314	active site
329726010315	(T/H)XGH motif; other site
329726010316	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
329726010317	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
329726010318	active site
329726010319	HIGH motif; other site
329726010320	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
329726010321	KMSKS motif; other site
329726010322	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
329726010323	tRNA binding surface [nucleotide binding]; other site
329726010324	anticodon binding site; other site
329726010325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726010326	S-adenosylmethionine binding site [chemical binding]; other site
329726010327	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726010328	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726010329	phosphopeptide binding site; other site
329726010330	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726010331	PAS fold; Region: PAS_3; pfam08447
329726010332	putative active site [active]
329726010333	heme pocket [chemical binding]; other site
329726010334	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726010335	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726010336	metal binding site [ion binding]; metal-binding site
329726010337	active site
329726010338	I-site; other site
329726010339	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726010340	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
329726010341	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726010342	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726010343	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726010344	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726010345	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
329726010346	protein binding site [polypeptide binding]; other site
329726010347	recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341
329726010348	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726010349	Walker A motif; other site
329726010350	ATP binding site [chemical binding]; other site
329726010351	Walker B motif; other site
329726010352	arginine finger; other site
329726010353	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
329726010354	putative lyase; Provisional; Region: PRK09687
329726010355	Transposase, Mutator family; Region: Transposase_mut; pfam00872
329726010356	MULE transposase domain; Region: MULE; pfam10551
329726010357	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
329726010358	D1 interface; other site
329726010359	chlorophyll binding site; other site
329726010360	pheophytin binding site; other site
329726010361	beta carotene binding site; other site
329726010362	cytochrome b559 beta interface; other site
329726010363	quinone binding site; other site
329726010364	cytochrome b559 alpha interface; other site
329726010365	protein J interface; other site
329726010366	protein H interface; other site
329726010367	protein X interface; other site
329726010368	core light harvesting protein interface; other site
329726010369	protein L interface; other site
329726010370	CP43 interface; other site
329726010371	protein T interface; other site
329726010372	Fe binding site [ion binding]; other site
329726010373	protein M interface; other site
329726010374	Mn-stabilizing polypeptide interface; other site
329726010375	bromide binding site; other site
329726010376	cytochrome c-550 interface; other site
329726010377	M28 Zn-Peptidases; Region: M28_like_1; cd05640
329726010378	Peptidase family M28; Region: Peptidase_M28; pfam04389
329726010379	metal binding site [ion binding]; metal-binding site
329726010380	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
329726010381	Transposase IS200 like; Region: Y1_Tnp; pfam01797
329726010382	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
329726010383	ATP-binding site [chemical binding]; other site
329726010384	Gluconate-6-phosphate binding site [chemical binding]; other site
329726010385	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726010386	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726010387	Walker A/P-loop; other site
329726010388	ATP binding site [chemical binding]; other site
329726010389	Q-loop/lid; other site
329726010390	ribosomal protein S16; Region: rps16; CHL00005
329726010391	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
329726010392	KH domain; Region: KH_4; pfam13083
329726010393	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
329726010394	PhoH-like protein; Region: PhoH; pfam02562
329726010395	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726010396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726010397	S-adenosylmethionine binding site [chemical binding]; other site
329726010398	tellurium resistance terB-like protein; Region: terB_like; cd07177
329726010399	metal binding site [ion binding]; metal-binding site
329726010400	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
329726010401	RNA/DNA hybrid binding site [nucleotide binding]; other site
329726010402	active site
329726010403	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
329726010404	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
329726010405	feedback inhibition sensing region; other site
329726010406	homohexameric interface [polypeptide binding]; other site
329726010407	nucleotide binding site [chemical binding]; other site
329726010408	N-acetyl-L-glutamate binding site [chemical binding]; other site
329726010409	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
329726010410	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
329726010411	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
329726010412	NADH(P)-binding; Region: NAD_binding_10; pfam13460
329726010413	NAD(P) binding site [chemical binding]; other site
329726010414	putative active site [active]
329726010415	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
329726010416	catalytic residue [active]
329726010417	Protein of unknown function (DUF448); Region: DUF448; pfam04296
329726010418	putative RNA binding cleft [nucleotide binding]; other site
329726010419	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
329726010420	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
329726010421	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
329726010422	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
329726010423	RNA binding site [nucleotide binding]; other site
329726010424	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726010425	NACHT domain; Region: NACHT; pfam05729
329726010426	Walker A motif; other site
329726010427	ATP binding site [chemical binding]; other site
329726010428	Walker B motif; other site
329726010429	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726010430	putative active site [active]
329726010431	polyphosphate kinase; Provisional; Region: PRK05443
329726010432	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
329726010433	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
329726010434	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
329726010435	putative domain interface [polypeptide binding]; other site
329726010436	putative active site [active]
329726010437	catalytic site [active]
329726010438	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
329726010439	putative domain interface [polypeptide binding]; other site
329726010440	putative active site [active]
329726010441	catalytic site [active]
329726010442	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
329726010443	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
329726010444	N-acetyl-D-glucosamine binding site [chemical binding]; other site
329726010445	catalytic residue [active]
329726010446	Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27); Region: Auto_anti-p27; cl00713
329726010447	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726010448	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726010449	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
329726010450	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
329726010451	cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153
329726010452	Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433
329726010453	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
329726010454	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
329726010455	active site
329726010456	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726010457	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
329726010458	signal recognition particle protein; Provisional; Region: PRK10867
329726010459	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
329726010460	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
329726010461	P loop; other site
329726010462	GTP binding site [chemical binding]; other site
329726010463	Signal peptide binding domain; Region: SRP_SPB; pfam02978
329726010464	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726010465	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726010466	Coenzyme A binding pocket [chemical binding]; other site
329726010467	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
329726010468	Fatty acid desaturase; Region: FA_desaturase; pfam00487
329726010469	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
329726010470	Di-iron ligands [ion binding]; other site
329726010471	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
329726010472	EamA-like transporter family; Region: EamA; pfam00892
329726010473	EamA-like transporter family; Region: EamA; pfam00892
329726010474	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
329726010475	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
329726010476	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
329726010477	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726010478	ATP binding site [chemical binding]; other site
329726010479	putative Mg++ binding site [ion binding]; other site
329726010480	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726010481	nucleotide binding region [chemical binding]; other site
329726010482	ATP-binding site [chemical binding]; other site
329726010483	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
329726010484	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
329726010485	ligand binding site [chemical binding]; other site
329726010486	active site
329726010487	UGI interface [polypeptide binding]; other site
329726010488	catalytic site [active]
329726010489	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
329726010490	EamA-like transporter family; Region: EamA; pfam00892
329726010491	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
329726010492	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
329726010493	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
329726010494	iron-sulfur cluster [ion binding]; other site
329726010495	[2Fe-2S] cluster binding site [ion binding]; other site
329726010496	EamA-like transporter family; Region: EamA; pfam00892
329726010497	EamA-like transporter family; Region: EamA; pfam00892
329726010498	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
329726010499	Cytochrome P450; Region: p450; cl12078
329726010500	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
329726010501	Predicted permease [General function prediction only]; Region: COG3329
329726010502	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
329726010503	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726010504	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
329726010505	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
329726010506	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
329726010507	putative catalytic residues [active]
329726010508	Transcriptional regulator [Transcription]; Region: LysR; COG0583
329726010509	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726010510	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
329726010511	putative effector binding pocket; other site
329726010512	dimerization interface [polypeptide binding]; other site
329726010513	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
329726010514	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
329726010515	MOSC domain; Region: MOSC; pfam03473
329726010516	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
329726010517	trimer interface [polypeptide binding]; other site
329726010518	putative Zn binding site [ion binding]; other site
329726010519	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
329726010520	MgtC family; Region: MgtC; pfam02308
329726010521	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726010522	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726010523	Predicted ATPase [General function prediction only]; Region: COG3899
329726010524	Uncharacterized conserved protein [Function unknown]; Region: COG3349
329726010525	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726010526	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726010527	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726010528	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726010529	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726010530	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726010531	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726010532	Homeodomain-like domain; Region: HTH_23; pfam13384
329726010533	Winged helix-turn helix; Region: HTH_29; pfam13551
329726010534	Homeodomain-like domain; Region: HTH_32; pfam13565
329726010535	Homeodomain-like domain; Region: HTH_23; pfam13384
329726010536	Winged helix-turn helix; Region: HTH_29; pfam13551
329726010537	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
329726010538	anti sigma factor interaction site; other site
329726010539	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
329726010540	regulatory phosphorylation site [posttranslational modification]; other site
329726010541	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
329726010542	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
329726010543	Transposase; Region: HTH_Tnp_IS630; pfam01710
329726010544	Winged helix-turn helix; Region: HTH_33; pfam13592
329726010545	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726010546	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726010547	Homeodomain-like domain; Region: HTH_23; pfam13384
329726010548	Winged helix-turn helix; Region: HTH_29; pfam13551
329726010549	Homeodomain-like domain; Region: HTH_32; pfam13565
329726010550	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726010551	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
329726010552	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
329726010553	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726010554	von Willebrand factor; Region: vWF_A; pfam12450
329726010555	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
329726010556	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
329726010557	metal ion-dependent adhesion site (MIDAS); other site
329726010558	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
329726010559	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
329726010560	dimerization interface [polypeptide binding]; other site
329726010561	putative DNA binding site [nucleotide binding]; other site
329726010562	putative Zn2+ binding site [ion binding]; other site
329726010563	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
329726010564	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010565	binding surface
329726010566	Tetratricopeptide repeat; Region: TPR_9; pfam13371
329726010567	TPR motif; other site
329726010568	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
329726010569	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726010570	dimerization interface [polypeptide binding]; other site
329726010571	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
329726010572	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726010573	putative active site [active]
329726010574	heme pocket [chemical binding]; other site
329726010575	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726010576	dimer interface [polypeptide binding]; other site
329726010577	phosphorylation site [posttranslational modification]
329726010578	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726010579	ATP binding site [chemical binding]; other site
329726010580	Mg2+ binding site [ion binding]; other site
329726010581	G-X-G motif; other site
329726010582	CpeS-like protein; Region: CpeS; pfam09367
329726010583	Exoribonuclease R [Transcription]; Region: VacB; COG0557
329726010584	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
329726010585	RNB domain; Region: RNB; pfam00773
329726010586	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
329726010587	RNA binding site [nucleotide binding]; other site
329726010588	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
329726010589	PhoU domain; Region: PhoU; pfam01895
329726010590	PhoU domain; Region: PhoU; pfam01895
329726010591	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
329726010592	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
329726010593	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
329726010594	active site
329726010595	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
329726010596	yiaA/B two helix domain; Region: YiaAB; cl01759
329726010597	Predicted transcriptional regulators [Transcription]; Region: COG1695
329726010598	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
329726010599	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726010600	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726010601	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726010602	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726010603	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726010604	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726010605	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726010606	Homeodomain-like domain; Region: HTH_23; pfam13384
329726010607	Winged helix-turn helix; Region: HTH_29; pfam13551
329726010608	argininosuccinate synthase; Provisional; Region: PRK13820
329726010609	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
329726010610	ANP binding site [chemical binding]; other site
329726010611	Substrate Binding Site II [chemical binding]; other site
329726010612	Substrate Binding Site I [chemical binding]; other site
329726010613	Permease; Region: Permease; cl00510
329726010614	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
329726010615	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
329726010616	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
329726010617	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
329726010618	rod shape-determining protein MreB; Provisional; Region: PRK13930
329726010619	MreB and similar proteins; Region: MreB_like; cd10225
329726010620	nucleotide binding site [chemical binding]; other site
329726010621	Mg binding site [ion binding]; other site
329726010622	putative protofilament interaction site [polypeptide binding]; other site
329726010623	RodZ interaction site [polypeptide binding]; other site
329726010624	membrane protein; Provisional; Region: PRK14419
329726010625	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
329726010626	cobyric acid synthase; Provisional; Region: PRK00784
329726010627	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
329726010628	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
329726010629	catalytic triad [active]
329726010630	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
329726010631	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
329726010632	homodimer interface [polypeptide binding]; other site
329726010633	metal binding site [ion binding]; metal-binding site
329726010634	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
329726010635	homodimer interface [polypeptide binding]; other site
329726010636	active site
329726010637	putative chemical substrate binding site [chemical binding]; other site
329726010638	metal binding site [ion binding]; metal-binding site
329726010639	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
329726010640	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
329726010641	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
329726010642	active site
329726010643	catalytic residues [active]
329726010644	DNA binding site [nucleotide binding]
329726010645	Int/Topo IB signature motif; other site
329726010646	putative internal virion protein; Provisional; Region: PHA03415
329726010647	large terminase protein; Provisional; Region: 17; PHA02533
329726010648	Terminase-like family; Region: Terminase_6; pfam03237
329726010649	anthranilate synthase component I; Provisional; Region: PRK13569
329726010650	formyl-coenzyme A transferase; Provisional; Region: PRK05398
329726010651	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
329726010652	active site
329726010653	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726010654	VanW like protein; Region: VanW; pfam04294
329726010655	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
329726010656	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
329726010657	Walker A/P-loop; other site
329726010658	ATP binding site [chemical binding]; other site
329726010659	Q-loop/lid; other site
329726010660	ABC transporter signature motif; other site
329726010661	Walker B; other site
329726010662	D-loop; other site
329726010663	H-loop/switch region; other site
329726010664	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
329726010665	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
329726010666	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
329726010667	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
329726010668	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
329726010669	TM-ABC transporter signature motif; other site
329726010670	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
329726010671	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
329726010672	active site
329726010673	dimer interface [polypeptide binding]; other site
329726010674	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
329726010675	dimer interface [polypeptide binding]; other site
329726010676	active site
329726010677	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726010678	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726010679	phosphopeptide binding site; other site
329726010680	Predicted permeases [General function prediction only]; Region: COG0679
329726010681	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
329726010682	hypothetical protein; Validated; Region: PRK02101
329726010683	Homeodomain-like domain; Region: HTH_23; pfam13384
329726010684	Winged helix-turn helix; Region: HTH_29; pfam13551
329726010685	Winged helix-turn helix; Region: HTH_33; pfam13592
329726010686	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726010687	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726010688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726010689	S-adenosylmethionine binding site [chemical binding]; other site
329726010690	Cache domain; Region: Cache_1; pfam02743
329726010691	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726010692	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726010693	dimer interface [polypeptide binding]; other site
329726010694	phosphorylation site [posttranslational modification]
329726010695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726010696	ATP binding site [chemical binding]; other site
329726010697	Mg2+ binding site [ion binding]; other site
329726010698	G-X-G motif; other site
329726010699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726010700	Response regulator receiver domain; Region: Response_reg; pfam00072
329726010701	active site
329726010702	phosphorylation site [posttranslational modification]
329726010703	intermolecular recognition site; other site
329726010704	dimerization interface [polypeptide binding]; other site
329726010705	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
329726010706	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726010707	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
329726010708	Walker A/P-loop; other site
329726010709	ATP binding site [chemical binding]; other site
329726010710	Q-loop/lid; other site
329726010711	ABC transporter signature motif; other site
329726010712	Walker B; other site
329726010713	D-loop; other site
329726010714	H-loop/switch region; other site
329726010715	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
329726010716	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726010717	Homeodomain-like domain; Region: HTH_23; pfam13384
329726010718	Winged helix-turn helix; Region: HTH_29; pfam13551
329726010719	Homeodomain-like domain; Region: HTH_32; pfam13565
329726010720	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
329726010721	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
329726010722	hydroxyglutarate oxidase; Provisional; Region: PRK11728
329726010723	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
329726010724	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
329726010725	AAA ATPase domain; Region: AAA_16; pfam13191
329726010726	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726010727	WD domain, G-beta repeat; Region: WD40; pfam00400
329726010728	WD domain, G-beta repeat; Region: WD40; pfam00400
329726010729	WD domain, G-beta repeat; Region: WD40; pfam00400
329726010730	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726010731	structural tetrad; other site
329726010732	WD domain, G-beta repeat; Region: WD40; pfam00400
329726010733	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
329726010734	active site
329726010735	HEAT repeats; Region: HEAT_2; pfam13646
329726010736	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726010737	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726010738	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726010739	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726010740	S-adenosylmethionine binding site [chemical binding]; other site
329726010741	SnoaL-like domain; Region: SnoaL_2; pfam12680
329726010742	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726010743	GAF domain; Region: GAF_3; pfam13492
329726010744	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726010745	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726010746	DNA binding residues [nucleotide binding]
329726010747	dimerization interface [polypeptide binding]; other site
329726010748	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
329726010749	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
329726010750	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
329726010751	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010752	TPR motif; other site
329726010753	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726010754	binding surface
329726010755	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726010756	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010757	TPR motif; other site
329726010758	binding surface
329726010759	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726010760	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010761	binding surface
329726010762	TPR motif; other site
329726010763	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726010764	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726010765	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010766	TPR motif; other site
329726010767	binding surface
329726010768	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726010769	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010770	binding surface
329726010771	TPR motif; other site
329726010772	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726010773	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010774	binding surface
329726010775	TPR motif; other site
329726010776	TIR domain; Region: TIR_2; pfam13676
329726010777	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
329726010778	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726010779	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
329726010780	ligand binding site [chemical binding]; other site
329726010781	dimer interface [polypeptide binding]; other site
329726010782	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726010783	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726010784	S-adenosylmethionine binding site [chemical binding]; other site
329726010785	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
329726010786	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726010787	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726010788	metal binding site [ion binding]; metal-binding site
329726010789	active site
329726010790	I-site; other site
329726010791	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
329726010792	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
329726010793	putative tRNA-binding site [nucleotide binding]; other site
329726010794	B3/4 domain; Region: B3_4; pfam03483
329726010795	tRNA synthetase B5 domain; Region: B5; smart00874
329726010796	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
329726010797	dimer interface [polypeptide binding]; other site
329726010798	motif 1; other site
329726010799	motif 3; other site
329726010800	motif 2; other site
329726010801	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
329726010802	YcfA-like protein; Region: YcfA; pfam07927
329726010803	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
329726010804	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726010805	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726010806	active site
329726010807	ATP binding site [chemical binding]; other site
329726010808	substrate binding site [chemical binding]; other site
329726010809	activation loop (A-loop); other site
329726010810	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726010811	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726010812	active site
329726010813	ATP binding site [chemical binding]; other site
329726010814	substrate binding site [chemical binding]; other site
329726010815	activation loop (A-loop); other site
329726010816	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726010817	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726010818	active site
329726010819	ATP binding site [chemical binding]; other site
329726010820	substrate binding site [chemical binding]; other site
329726010821	activation loop (A-loop); other site
329726010822	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726010823	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726010824	active site
329726010825	ATP binding site [chemical binding]; other site
329726010826	substrate binding site [chemical binding]; other site
329726010827	activation loop (A-loop); other site
329726010828	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726010829	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726010830	active site
329726010831	ATP binding site [chemical binding]; other site
329726010832	substrate binding site [chemical binding]; other site
329726010833	activation loop (A-loop); other site
329726010834	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726010835	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726010836	active site
329726010837	ATP binding site [chemical binding]; other site
329726010838	substrate binding site [chemical binding]; other site
329726010839	activation loop (A-loop); other site
329726010840	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
329726010841	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
329726010842	G1 box; other site
329726010843	GTP/Mg2+ binding site [chemical binding]; other site
329726010844	Switch I region; other site
329726010845	G2 box; other site
329726010846	Switch II region; other site
329726010847	G3 box; other site
329726010848	G4 box; other site
329726010849	G5 box; other site
329726010850	Domain of unknown function (DUF697); Region: DUF697; pfam05128
329726010851	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
329726010852	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
329726010853	putative ligand binding site [chemical binding]; other site
329726010854	Predicted transcriptional regulators [Transcription]; Region: COG1695
329726010855	Transcriptional regulator PadR-like family; Region: PadR; cl17335
329726010856	Tic22-like family; Region: Tic22; pfam04278
329726010857	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
329726010858	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726010859	S-adenosylmethionine binding site [chemical binding]; other site
329726010860	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
329726010861	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
329726010862	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
329726010863	hexamer interface [polypeptide binding]; other site
329726010864	ligand binding site [chemical binding]; other site
329726010865	putative active site [active]
329726010866	NAD(P) binding site [chemical binding]; other site
329726010867	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
329726010868	NADH(P)-binding; Region: NAD_binding_10; pfam13460
329726010869	NAD(P) binding site [chemical binding]; other site
329726010870	putative active site [active]
329726010871	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
329726010872	putative active site [active]
329726010873	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
329726010874	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
329726010875	Domain of unknown function DUF39; Region: DUF39; pfam01837
329726010876	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
329726010877	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726010878	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
329726010879	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
329726010880	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
329726010881	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
329726010882	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
329726010883	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
329726010884	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
329726010885	Rhomboid family; Region: Rhomboid; pfam01694
329726010886	RibD C-terminal domain; Region: RibD_C; cl17279
329726010887	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
329726010888	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726010889	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726010890	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
329726010891	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
329726010892	ligand binding site [chemical binding]; other site
329726010893	homodimer interface [polypeptide binding]; other site
329726010894	NAD(P) binding site [chemical binding]; other site
329726010895	trimer interface B [polypeptide binding]; other site
329726010896	trimer interface A [polypeptide binding]; other site
329726010897	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
329726010898	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
329726010899	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
329726010900	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
329726010901	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
329726010902	AIR carboxylase; Region: AIRC; smart01001
329726010903	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726010904	Coenzyme A binding pocket [chemical binding]; other site
329726010905	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
329726010906	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726010907	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
329726010908	protein binding site [polypeptide binding]; other site
329726010909	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
329726010910	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
329726010911	Helix-turn-helix domain; Region: HTH_25; pfam13413
329726010912	non-specific DNA binding site [nucleotide binding]; other site
329726010913	salt bridge; other site
329726010914	sequence-specific DNA binding site [nucleotide binding]; other site
329726010915	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
329726010916	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
329726010917	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
329726010918	RNA binding surface [nucleotide binding]; other site
329726010919	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
329726010920	active site
329726010921	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
329726010922	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
329726010923	active site
329726010924	substrate binding site [chemical binding]; other site
329726010925	cosubstrate binding site; other site
329726010926	catalytic site [active]
329726010927	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
329726010928	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
329726010929	active site
329726010930	ribulose/triose binding site [chemical binding]; other site
329726010931	phosphate binding site [ion binding]; other site
329726010932	substrate (anthranilate) binding pocket [chemical binding]; other site
329726010933	product (indole) binding pocket [chemical binding]; other site
329726010934	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
329726010935	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
329726010936	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
329726010937	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
329726010938	active site
329726010939	putative substrate binding region [chemical binding]; other site
329726010940	TPR repeat; Region: TPR_11; pfam13414
329726010941	TPR repeat; Region: TPR_11; pfam13414
329726010942	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726010943	binding surface
329726010944	TPR motif; other site
329726010945	TPR repeat; Region: TPR_11; pfam13414
329726010946	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
329726010947	anti sigma factor interaction site; other site
329726010948	regulatory phosphorylation site [posttranslational modification]; other site
329726010949	cell division protein; Validated; Region: ftsH; CHL00176
329726010950	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726010951	Walker A motif; other site
329726010952	ATP binding site [chemical binding]; other site
329726010953	Walker B motif; other site
329726010954	arginine finger; other site
329726010955	Peptidase family M41; Region: Peptidase_M41; pfam01434
329726010956	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
329726010957	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
329726010958	putative active site [active]
329726010959	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
329726010960	putative active site [active]
329726010961	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
329726010962	active site
329726010963	SAM binding site [chemical binding]; other site
329726010964	homodimer interface [polypeptide binding]; other site
329726010965	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
329726010966	active site
329726010967	dimer interface [polypeptide binding]; other site
329726010968	hypothetical protein; Reviewed; Region: PRK00024
329726010969	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
329726010970	MPN+ (JAMM) motif; other site
329726010971	Zinc-binding site [ion binding]; other site
329726010972	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
329726010973	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
329726010974	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
329726010975	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
329726010976	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726010977	FeS/SAM binding site; other site
329726010978	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
329726010979	Mechanosensitive ion channel; Region: MS_channel; pfam00924
329726010980	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726010981	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726010982	ligand binding site [chemical binding]; other site
329726010983	flexible hinge region; other site
329726010984	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
329726010985	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
329726010986	homotetramer interface [polypeptide binding]; other site
329726010987	FMN binding site [chemical binding]; other site
329726010988	homodimer contacts [polypeptide binding]; other site
329726010989	putative active site [active]
329726010990	putative substrate binding site [chemical binding]; other site
329726010991	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
329726010992	Family description; Region: UvrD_C_2; pfam13538
329726010993	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
329726010994	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
329726010995	NodB motif; other site
329726010996	active site
329726010997	catalytic site [active]
329726010998	metal binding site [ion binding]; metal-binding site
329726010999	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
329726011000	Amino acid permease; Region: AA_permease_2; pfam13520
329726011001	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
329726011002	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
329726011003	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
329726011004	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
329726011005	GTP binding site; other site
329726011006	hypothetical protein; Provisional; Region: PRK07394
329726011007	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
329726011008	Transcriptional regulator [Transcription]; Region: LysR; COG0583
329726011009	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726011010	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
329726011011	dimerization interface [polypeptide binding]; other site
329726011012	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
329726011013	triosephosphate isomerase; Provisional; Region: PRK14565
329726011014	substrate binding site [chemical binding]; other site
329726011015	dimer interface [polypeptide binding]; other site
329726011016	catalytic triad [active]
329726011017	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
329726011018	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726011019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726011020	Walker A/P-loop; other site
329726011021	ATP binding site [chemical binding]; other site
329726011022	Q-loop/lid; other site
329726011023	ABC transporter signature motif; other site
329726011024	Walker B; other site
329726011025	D-loop; other site
329726011026	H-loop/switch region; other site
329726011027	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726011028	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726011029	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
329726011030	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011031	binding surface
329726011032	TPR motif; other site
329726011033	TPR repeat; Region: TPR_11; pfam13414
329726011034	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
329726011035	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
329726011036	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
329726011037	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726011038	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726011039	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726011040	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726011041	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726011042	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
329726011043	heme-binding site [chemical binding]; other site
329726011044	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
329726011045	heme-binding site [chemical binding]; other site
329726011046	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
329726011047	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
329726011048	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
329726011049	ring oligomerisation interface [polypeptide binding]; other site
329726011050	ATP/Mg binding site [chemical binding]; other site
329726011051	stacking interactions; other site
329726011052	hinge regions; other site
329726011053	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
329726011054	oligomerisation interface [polypeptide binding]; other site
329726011055	mobile loop; other site
329726011056	roof hairpin; other site
329726011057	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
329726011058	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
329726011059	active site
329726011060	Late competence development protein ComFB; Region: ComFB; pfam10719
329726011061	argininosuccinate lyase; Provisional; Region: PRK00855
329726011062	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
329726011063	active sites [active]
329726011064	tetramer interface [polypeptide binding]; other site
329726011065	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
329726011066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726011067	dimer interface [polypeptide binding]; other site
329726011068	conserved gate region; other site
329726011069	putative PBP binding loops; other site
329726011070	ABC-ATPase subunit interface; other site
329726011071	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726011072	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
329726011073	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
329726011074	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
329726011075	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
329726011076	dimer interface [polypeptide binding]; other site
329726011077	anticodon binding site; other site
329726011078	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
329726011079	homodimer interface [polypeptide binding]; other site
329726011080	motif 1; other site
329726011081	active site
329726011082	motif 2; other site
329726011083	GAD domain; Region: GAD; pfam02938
329726011084	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
329726011085	active site
329726011086	motif 3; other site
329726011087	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
329726011088	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
329726011089	Glycoprotease family; Region: Peptidase_M22; pfam00814
329726011090	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
329726011091	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
329726011092	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
329726011093	GMP synthase; Reviewed; Region: guaA; PRK00074
329726011094	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
329726011095	AMP/PPi binding site [chemical binding]; other site
329726011096	candidate oxyanion hole; other site
329726011097	catalytic triad [active]
329726011098	potential glutamine specificity residues [chemical binding]; other site
329726011099	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
329726011100	ATP Binding subdomain [chemical binding]; other site
329726011101	Ligand Binding sites [chemical binding]; other site
329726011102	Dimerization subdomain; other site
329726011103	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726011104	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726011105	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726011106	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726011107	dimer interface [polypeptide binding]; other site
329726011108	phosphorylation site [posttranslational modification]
329726011109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726011110	ATP binding site [chemical binding]; other site
329726011111	Mg2+ binding site [ion binding]; other site
329726011112	G-X-G motif; other site
329726011113	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726011114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726011115	active site
329726011116	phosphorylation site [posttranslational modification]
329726011117	intermolecular recognition site; other site
329726011118	dimerization interface [polypeptide binding]; other site
329726011119	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
329726011120	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
329726011121	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
329726011122	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726011123	Homeodomain-like domain; Region: HTH_23; pfam13384
329726011124	Winged helix-turn helix; Region: HTH_29; pfam13551
329726011125	Homeodomain-like domain; Region: HTH_32; pfam13565
329726011126	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
329726011127	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726011128	G8 domain; Region: G8; pfam10162
329726011129	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726011130	Homeodomain-like domain; Region: HTH_23; pfam13384
329726011131	Winged helix-turn helix; Region: HTH_29; pfam13551
329726011132	Homeodomain-like domain; Region: HTH_32; pfam13565
329726011133	TfoX N-terminal domain; Region: TfoX_N; pfam04993
329726011134	Predicted membrane protein [Function unknown]; Region: COG4270
329726011135	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
329726011136	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
329726011137	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
329726011138	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
329726011139	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
329726011140	motif 1; other site
329726011141	active site
329726011142	motif 2; other site
329726011143	motif 3; other site
329726011144	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
329726011145	methionine sulfoxide reductase B; Provisional; Region: PRK00222
329726011146	SelR domain; Region: SelR; pfam01641
329726011147	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
329726011148	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726011149	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726011150	Walker A/P-loop; other site
329726011151	ATP binding site [chemical binding]; other site
329726011152	Q-loop/lid; other site
329726011153	ABC transporter signature motif; other site
329726011154	Walker B; other site
329726011155	D-loop; other site
329726011156	H-loop/switch region; other site
329726011157	cytochrome f; Region: petA; CHL00037
329726011158	apocytochrome f; Reviewed; Region: PRK02693
329726011159	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
329726011160	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
329726011161	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
329726011162	cytochrome b subunit interaction site [polypeptide binding]; other site
329726011163	[2Fe-2S] cluster binding site [ion binding]; other site
329726011164	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
329726011165	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
329726011166	Predicted membrane protein [Function unknown]; Region: COG2259
329726011167	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726011168	Thymidylate synthase complementing protein; Region: Thy1; cl03630
329726011169	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
329726011170	C-terminal peptidase (prc); Region: prc; TIGR00225
329726011171	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
329726011172	protein binding site [polypeptide binding]; other site
329726011173	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
329726011174	Catalytic dyad [active]
329726011175	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
329726011176	LrgA family; Region: LrgA; pfam03788
329726011177	threonine dehydratase; Reviewed; Region: PRK09224
329726011178	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
329726011179	tetramer interface [polypeptide binding]; other site
329726011180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726011181	catalytic residue [active]
329726011182	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
329726011183	putative Ile/Val binding site [chemical binding]; other site
329726011184	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
329726011185	putative Ile/Val binding site [chemical binding]; other site
329726011186	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
329726011187	V4R domain; Region: V4R; pfam02830
329726011188	COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in...; Region: Commd; cl06336
329726011189	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
329726011190	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
329726011191	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726011192	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726011193	catalytic loop [active]
329726011194	iron binding site [ion binding]; other site
329726011195	Phycobilisome protein; Region: Phycobilisome; cl08227
329726011196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011197	TPR motif; other site
329726011198	TPR repeat; Region: TPR_11; pfam13414
329726011199	binding surface
329726011200	Domain of unknown function DUF302; Region: DUF302; cl01364
329726011201	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726011202	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
329726011203	NAD(P) binding site [chemical binding]; other site
329726011204	active site
329726011205	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726011206	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726011207	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
329726011208	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
329726011209	inhibitor-cofactor binding pocket; inhibition site
329726011210	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726011211	catalytic residue [active]
329726011212	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
329726011213	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726011214	Coenzyme A binding pocket [chemical binding]; other site
329726011215	proton extrusion protein PcxA; Provisional; Region: PRK02507
329726011216	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726011217	structural tetrad; other site
329726011218	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726011219	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726011220	structural tetrad; other site
329726011221	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726011222	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726011223	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
329726011224	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
329726011225	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
329726011226	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
329726011227	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
329726011228	metal ion-dependent adhesion site (MIDAS); other site
329726011229	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
329726011230	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
329726011231	cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153
329726011232	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
329726011233	YHS domain; Region: YHS; pfam04945
329726011234	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
329726011235	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
329726011236	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
329726011237	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
329726011238	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
329726011239	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726011240	ATP binding site [chemical binding]; other site
329726011241	Mg2+ binding site [ion binding]; other site
329726011242	G-X-G motif; other site
329726011243	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
329726011244	anchoring element; other site
329726011245	dimer interface [polypeptide binding]; other site
329726011246	ATP binding site [chemical binding]; other site
329726011247	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
329726011248	active site
329726011249	putative metal-binding site [ion binding]; other site
329726011250	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
329726011251	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726011252	putative active site [active]
329726011253	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
329726011254	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726011255	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726011256	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
329726011257	dimer interface [polypeptide binding]; other site
329726011258	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
329726011259	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
329726011260	substrate binding site [chemical binding]; other site
329726011261	ligand binding site [chemical binding]; other site
329726011262	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
329726011263	putative rRNA binding site [nucleotide binding]; other site
329726011264	Cupin domain; Region: Cupin_2; pfam07883
329726011265	Low molecular weight phosphatase family; Region: LMWPc; cl00105
329726011266	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
329726011267	active site
329726011268	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
329726011269	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
329726011270	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
329726011271	putative active site [active]
329726011272	putative substrate binding site [chemical binding]; other site
329726011273	putative cosubstrate binding site; other site
329726011274	catalytic site [active]
329726011275	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
329726011276	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726011277	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
329726011278	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
329726011279	DXD motif; other site
329726011280	PilZ domain; Region: PilZ; pfam07238
329726011281	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
329726011282	nudix motif; other site
329726011283	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
329726011284	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
329726011285	nucleotide binding site [chemical binding]; other site
329726011286	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
329726011287	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
329726011288	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
329726011289	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726011290	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726011291	phosphopeptide binding site; other site
329726011292	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
329726011293	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726011294	phosphopeptide binding site; other site
329726011295	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726011296	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726011297	phosphopeptide binding site; other site
329726011298	WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998
329726011299	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726011300	Family description; Region: VCBS; pfam13517
329726011301	Family description; Region: VCBS; pfam13517
329726011302	Family description; Region: VCBS; pfam13517
329726011303	Family description; Region: VCBS; pfam13517
329726011304	Family description; Region: VCBS; pfam13517
329726011305	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
329726011306	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726011307	Walker A/P-loop; other site
329726011308	ATP binding site [chemical binding]; other site
329726011309	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726011310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726011311	active site
329726011312	phosphorylation site [posttranslational modification]
329726011313	intermolecular recognition site; other site
329726011314	dimerization interface [polypeptide binding]; other site
329726011315	FHA domain; Region: FHA; pfam00498
329726011316	phosphopeptide binding site; other site
329726011317	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726011318	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726011319	putative active site [active]
329726011320	heme pocket [chemical binding]; other site
329726011321	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
329726011322	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726011323	putative active site [active]
329726011324	heme pocket [chemical binding]; other site
329726011325	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726011326	dimer interface [polypeptide binding]; other site
329726011327	phosphorylation site [posttranslational modification]
329726011328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726011329	ATP binding site [chemical binding]; other site
329726011330	Mg2+ binding site [ion binding]; other site
329726011331	G-X-G motif; other site
329726011332	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
329726011333	arginine-tRNA ligase; Region: PLN02286
329726011334	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
329726011335	active site
329726011336	HIGH motif; other site
329726011337	KMSK motif region; other site
329726011338	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
329726011339	tRNA binding surface [nucleotide binding]; other site
329726011340	anticodon binding site; other site
329726011341	PetN; Region: PetN; pfam03742
329726011342	tocopherol O-methyltransferase; Region: PLN02244
329726011343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726011344	S-adenosylmethionine binding site [chemical binding]; other site
329726011345	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
329726011346	UbiA prenyltransferase family; Region: UbiA; pfam01040
329726011347	Protein kinase domain; Region: Pkinase; pfam00069
329726011348	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726011349	active site
329726011350	ATP binding site [chemical binding]; other site
329726011351	substrate binding site [chemical binding]; other site
329726011352	activation loop (A-loop); other site
329726011353	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726011354	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726011355	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726011356	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
329726011357	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
329726011358	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
329726011359	Transcriptional regulator [Transcription]; Region: LytR; COG1316
329726011360	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
329726011361	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
329726011362	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
329726011363	active site
329726011364	Substrate binding site; other site
329726011365	Mg++ binding site; other site
329726011366	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
329726011367	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
329726011368	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
329726011369	NAD(P) binding site [chemical binding]; other site
329726011370	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
329726011371	nudix motif; other site
329726011372	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
329726011373	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
329726011374	dimer interface [polypeptide binding]; other site
329726011375	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
329726011376	active site
329726011377	Fe binding site [ion binding]; other site
329726011378	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
329726011379	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
329726011380	30S ribosomal protein S1; Reviewed; Region: PRK07400
329726011381	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
329726011382	RNA binding site [nucleotide binding]; other site
329726011383	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
329726011384	RNA binding site [nucleotide binding]; other site
329726011385	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
329726011386	RNA binding site [nucleotide binding]; other site
329726011387	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
329726011388	ATP cone domain; Region: ATP-cone; pfam03477
329726011389	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
329726011390	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
329726011391	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
329726011392	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
329726011393	active site
329726011394	substrate binding site [chemical binding]; other site
329726011395	metal binding site [ion binding]; metal-binding site
329726011396	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
329726011397	ATP-sulfurylase; Region: ATPS; cd00517
329726011398	active site
329726011399	HXXH motif; other site
329726011400	flexible loop; other site
329726011401	Caspase domain; Region: Peptidase_C14; pfam00656
329726011402	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
329726011403	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
329726011404	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
329726011405	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
329726011406	putative active site [active]
329726011407	dimerization interface [polypeptide binding]; other site
329726011408	putative tRNAtyr binding site [nucleotide binding]; other site
329726011409	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
329726011410	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
329726011411	glutaminase active site [active]
329726011412	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
329726011413	dimer interface [polypeptide binding]; other site
329726011414	active site
329726011415	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
329726011416	dimer interface [polypeptide binding]; other site
329726011417	active site
329726011418	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
329726011419	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
329726011420	acyl-activating enzyme (AAE) consensus motif; other site
329726011421	active site
329726011422	AMP binding site [chemical binding]; other site
329726011423	CoA binding site [chemical binding]; other site
329726011424	CHASE domain; Region: CHASE; pfam03924
329726011425	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726011426	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726011427	metal binding site [ion binding]; metal-binding site
329726011428	active site
329726011429	I-site; other site
329726011430	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
329726011431	active site
329726011432	catalytic triad [active]
329726011433	oxyanion hole [active]
329726011434	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726011435	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726011436	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726011437	Homeodomain-like domain; Region: HTH_23; pfam13384
329726011438	Winged helix-turn helix; Region: HTH_29; pfam13551
329726011439	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
329726011440	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
329726011441	DXD motif; other site
329726011442	Radical SAM superfamily; Region: Radical_SAM; pfam04055
329726011443	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726011444	FeS/SAM binding site; other site
329726011445	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
329726011446	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
329726011447	DRTGG domain; Region: DRTGG; pfam07085
329726011448	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
329726011449	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
329726011450	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
329726011451	active site
329726011452	SAM binding site [chemical binding]; other site
329726011453	homodimer interface [polypeptide binding]; other site
329726011454	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726011455	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726011456	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726011457	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
329726011458	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726011459	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726011460	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726011461	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
329726011462	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
329726011463	FtsH Extracellular; Region: FtsH_ext; pfam06480
329726011464	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
329726011465	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726011466	Walker A motif; other site
329726011467	ATP binding site [chemical binding]; other site
329726011468	Walker B motif; other site
329726011469	arginine finger; other site
329726011470	Peptidase family M41; Region: Peptidase_M41; pfam01434
329726011471	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011472	binding surface
329726011473	TPR repeat; Region: TPR_11; pfam13414
329726011474	TPR motif; other site
329726011475	TPR repeat; Region: TPR_11; pfam13414
329726011476	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011477	binding surface
329726011478	TPR motif; other site
329726011479	TPR repeat; Region: TPR_11; pfam13414
329726011480	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011481	binding surface
329726011482	TPR motif; other site
329726011483	TPR repeat; Region: TPR_11; pfam13414
329726011484	PBP superfamily domain; Region: PBP_like_2; cl17296
329726011485	Cupin domain; Region: Cupin_2; cl17218
329726011486	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726011487	Coenzyme A binding pocket [chemical binding]; other site
329726011488	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726011489	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
329726011490	Cupin domain; Region: Cupin_2; cl17218
329726011491	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
329726011492	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
329726011493	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
329726011494	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
329726011495	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
329726011496	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
329726011497	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
329726011498	active site
329726011499	catalytic tetrad [active]
329726011500	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
329726011501	active site
329726011502	Protein of unknown function (DUF2459); Region: DUF2459; cl09819
329726011503	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
329726011504	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
329726011505	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726011506	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726011507	structural tetrad; other site
329726011508	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726011509	structural tetrad; other site
329726011510	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726011511	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726011512	phosphopeptide binding site; other site
329726011513	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
329726011514	putative heme binding site [chemical binding]; other site
329726011515	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
329726011516	Phosphotransferase enzyme family; Region: APH; pfam01636
329726011517	active site
329726011518	substrate binding site [chemical binding]; other site
329726011519	ATP binding site [chemical binding]; other site
329726011520	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726011521	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726011522	active site
329726011523	ATP binding site [chemical binding]; other site
329726011524	substrate binding site [chemical binding]; other site
329726011525	activation loop (A-loop); other site
329726011526	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
329726011527	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726011528	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
329726011529	putative dimerization interface [polypeptide binding]; other site
329726011530	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
329726011531	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
329726011532	dimerization interface [polypeptide binding]; other site
329726011533	active site
329726011534	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
329726011535	Subunit I/III interface [polypeptide binding]; other site
329726011536	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
329726011537	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
329726011538	D-pathway; other site
329726011539	Putative ubiquinol binding site [chemical binding]; other site
329726011540	Low-spin heme (heme b) binding site [chemical binding]; other site
329726011541	Putative water exit pathway; other site
329726011542	Binuclear center (heme o3/CuB) [ion binding]; other site
329726011543	K-pathway; other site
329726011544	Putative proton exit pathway; other site
329726011545	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
329726011546	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
329726011547	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
329726011548	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
329726011549	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
329726011550	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
329726011551	UbiA prenyltransferase family; Region: UbiA; pfam01040
329726011552	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
329726011553	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726011554	Walker A/P-loop; other site
329726011555	ATP binding site [chemical binding]; other site
329726011556	Q-loop/lid; other site
329726011557	ABC transporter signature motif; other site
329726011558	Walker B; other site
329726011559	D-loop; other site
329726011560	H-loop/switch region; other site
329726011561	ABC-2 type transporter; Region: ABC2_membrane; cl17235
329726011562	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
329726011563	Tic20-like protein; Region: Tic20; pfam09685
329726011564	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
329726011565	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
329726011566	dimerization interface [polypeptide binding]; other site
329726011567	FAD binding pocket [chemical binding]; other site
329726011568	FAD binding motif [chemical binding]; other site
329726011569	catalytic residues [active]
329726011570	NAD binding pocket [chemical binding]; other site
329726011571	phosphate binding motif [ion binding]; other site
329726011572	beta-alpha-beta structure motif; other site
329726011573	TraB family; Region: TraB; pfam01963
329726011574	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
329726011575	intersubunit interface [polypeptide binding]; other site
329726011576	active site
329726011577	catalytic residue [active]
329726011578	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
329726011579	Recombination protein O N terminal; Region: RecO_N; pfam11967
329726011580	Recombination protein O C terminal; Region: RecO_C; pfam02565
329726011581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726011582	H+ Antiporter protein; Region: 2A0121; TIGR00900
329726011583	putative substrate translocation pore; other site
329726011584	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726011585	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726011586	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
329726011587	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
329726011588	Uncharacterized conserved protein [Function unknown]; Region: COG0398
329726011589	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
329726011590	Uncharacterized conserved protein [Function unknown]; Region: COG1543
329726011591	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
329726011592	active site
329726011593	substrate binding site [chemical binding]; other site
329726011594	catalytic site [active]
329726011595	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
329726011596	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
329726011597	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
329726011598	phosphate binding site [ion binding]; other site
329726011599	putative substrate binding pocket [chemical binding]; other site
329726011600	dimer interface [polypeptide binding]; other site
329726011601	cell division topological specificity factor MinE; Provisional; Region: PRK13988
329726011602	septum site-determining protein MinD; Region: minD_bact; TIGR01968
329726011603	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
329726011604	P-loop; other site
329726011605	ADP binding residues [chemical binding]; other site
329726011606	Switch I; other site
329726011607	Switch II; other site
329726011608	septum formation inhibitor; Reviewed; Region: minC; PRK00513
329726011609	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
329726011610	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
329726011611	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
329726011612	active site
329726011613	homodimer interface [polypeptide binding]; other site
329726011614	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
329726011615	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
329726011616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726011617	dimer interface [polypeptide binding]; other site
329726011618	conserved gate region; other site
329726011619	putative PBP binding loops; other site
329726011620	ABC-ATPase subunit interface; other site
329726011621	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
329726011622	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
329726011623	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
329726011624	active site
329726011625	SAM binding site [chemical binding]; other site
329726011626	homodimer interface [polypeptide binding]; other site
329726011627	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
329726011628	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
329726011629	active site
329726011630	TPR repeat; Region: TPR_11; pfam13414
329726011631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011632	binding surface
329726011633	TPR motif; other site
329726011634	TPR repeat; Region: TPR_11; pfam13414
329726011635	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011636	binding surface
329726011637	TPR motif; other site
329726011638	TPR repeat; Region: TPR_11; pfam13414
329726011639	CHAT domain; Region: CHAT; cl17868
329726011640	RNA polymerase sigma factor; Provisional; Region: PRK12518
329726011641	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726011642	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726011643	DNA binding residues [nucleotide binding]
329726011644	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
329726011645	dimer interface [polypeptide binding]; other site
329726011646	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
329726011647	AAA domain; Region: AAA_33; pfam13671
329726011648	ADP binding site [chemical binding]; other site
329726011649	magnesium binding site [ion binding]; other site
329726011650	putative shikimate binding site; other site
329726011651	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
329726011652	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
329726011653	putative di-iron ligands [ion binding]; other site
329726011654	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
329726011655	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
329726011656	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726011657	FeS/SAM binding site; other site
329726011658	TRAM domain; Region: TRAM; pfam01938
329726011659	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
329726011660	DNA protecting protein DprA; Region: dprA; TIGR00732
329726011661	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
329726011662	active site
329726011663	catalytic residues [active]
329726011664	metal binding site [ion binding]; metal-binding site
329726011665	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
329726011666	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
329726011667	interchain domain interface [polypeptide binding]; other site
329726011668	intrachain domain interface; other site
329726011669	Qi binding site; other site
329726011670	Qo binding site; other site
329726011671	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
329726011672	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
329726011673	Qi binding site; other site
329726011674	intrachain domain interface; other site
329726011675	interchain domain interface [polypeptide binding]; other site
329726011676	heme bH binding site [chemical binding]; other site
329726011677	heme bL binding site [chemical binding]; other site
329726011678	Qo binding site; other site
329726011679	carboxyl-terminal processing protease; Provisional; Region: PLN00049
329726011680	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
329726011681	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
329726011682	protein binding site [polypeptide binding]; other site
329726011683	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
329726011684	Catalytic dyad [active]
329726011685	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
329726011686	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
329726011687	Zn2+ binding site [ion binding]; other site
329726011688	Mg2+ binding site [ion binding]; other site
329726011689	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
329726011690	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
329726011691	RNA/DNA hybrid binding site [nucleotide binding]; other site
329726011692	active site
329726011693	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
329726011694	active site
329726011695	dimerization interface [polypeptide binding]; other site
329726011696	Integral membrane protein DUF92; Region: DUF92; pfam01940
329726011697	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726011698	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
329726011699	active site
329726011700	metal binding site [ion binding]; metal-binding site
329726011701	CAAX protease self-immunity; Region: Abi; pfam02517
329726011702	gamma-glutamyl kinase; Provisional; Region: PRK05429
329726011703	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
329726011704	nucleotide binding site [chemical binding]; other site
329726011705	homotetrameric interface [polypeptide binding]; other site
329726011706	putative phosphate binding site [ion binding]; other site
329726011707	putative allosteric binding site; other site
329726011708	PUA domain; Region: PUA; pfam01472
329726011709	Putative serine esterase (DUF676); Region: DUF676; pfam05057
329726011710	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726011711	NB-ARC domain; Region: NB-ARC; pfam00931
329726011712	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726011713	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726011714	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011715	binding surface
329726011716	TPR motif; other site
329726011717	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726011718	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011719	binding surface
329726011720	TPR motif; other site
329726011721	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726011722	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
329726011723	active site
329726011724	metal binding site [ion binding]; metal-binding site
329726011725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726011726	S-adenosylmethionine binding site [chemical binding]; other site
329726011727	Fatty acid desaturase; Region: FA_desaturase; pfam00487
329726011728	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
329726011729	Di-iron ligands [ion binding]; other site
329726011730	AAA ATPase domain; Region: AAA_16; pfam13191
329726011731	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
329726011732	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
329726011733	AAA ATPase domain; Region: AAA_16; pfam13191
329726011734	AAA domain; Region: AAA_22; pfam13401
329726011735	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
329726011736	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
329726011737	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
329726011738	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
329726011739	active site
329726011740	SAM binding site [chemical binding]; other site
329726011741	homodimer interface [polypeptide binding]; other site
329726011742	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
329726011743	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
329726011744	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
329726011745	homodimer interface [polypeptide binding]; other site
329726011746	Walker A motif; other site
329726011747	ATP binding site [chemical binding]; other site
329726011748	hydroxycobalamin binding site [chemical binding]; other site
329726011749	Walker B motif; other site
329726011750	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
329726011751	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
329726011752	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
329726011753	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
329726011754	Domain of unknown function DUF29; Region: DUF29; pfam01724
329726011755	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
329726011756	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
329726011757	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
329726011758	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
329726011759	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
329726011760	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
329726011761	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
329726011762	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
329726011763	putative translocon binding site; other site
329726011764	protein-rRNA interface [nucleotide binding]; other site
329726011765	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
329726011766	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
329726011767	G-X-X-G motif; other site
329726011768	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
329726011769	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
329726011770	23S rRNA interface [nucleotide binding]; other site
329726011771	5S rRNA interface [nucleotide binding]; other site
329726011772	putative antibiotic binding site [chemical binding]; other site
329726011773	L25 interface [polypeptide binding]; other site
329726011774	L27 interface [polypeptide binding]; other site
329726011775	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
329726011776	23S rRNA interface [nucleotide binding]; other site
329726011777	putative translocon interaction site; other site
329726011778	signal recognition particle (SRP54) interaction site; other site
329726011779	L23 interface [polypeptide binding]; other site
329726011780	trigger factor interaction site; other site
329726011781	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
329726011782	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
329726011783	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
329726011784	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
329726011785	RNA binding site [nucleotide binding]; other site
329726011786	ribosomal protein L5; Region: rpl5; CHL00078
329726011787	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
329726011788	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
329726011789	ribosomal protein S8; Region: rps8; CHL00042
329726011790	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
329726011791	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
329726011792	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
329726011793	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
329726011794	5S rRNA interface [nucleotide binding]; other site
329726011795	L27 interface [polypeptide binding]; other site
329726011796	23S rRNA interface [nucleotide binding]; other site
329726011797	L5 interface [polypeptide binding]; other site
329726011798	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
329726011799	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
329726011800	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
329726011801	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
329726011802	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
329726011803	SecY translocase; Region: SecY; pfam00344
329726011804	adenylate kinase; Provisional; Region: adk; PRK02496
329726011805	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
329726011806	AMP-binding site [chemical binding]; other site
329726011807	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
329726011808	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
329726011809	rRNA binding site [nucleotide binding]; other site
329726011810	predicted 30S ribosome binding site; other site
329726011811	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
329726011812	NlpC/P60 family; Region: NLPC_P60; pfam00877
329726011813	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726011814	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726011815	active site
329726011816	ATP binding site [chemical binding]; other site
329726011817	substrate binding site [chemical binding]; other site
329726011818	activation loop (A-loop); other site
329726011819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
329726011820	Domain of unknown function DUF11; Region: DUF11; cl17728
329726011821	Right handed beta helix region; Region: Beta_helix; pfam13229
329726011822	conserved repeat domain; Region: B_ant_repeat; TIGR01451
329726011823	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726011824	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA_subfamily_ECM; cd01450
329726011825	integrin inhibitor binding pocket; other site
329726011826	metal ion-dependent adhesion site (MIDAS); other site
329726011827	integrin-collagen binding site; other site
329726011828	putative vWF-collagen binding site; other site
329726011829	glycoprotein Ib (GpIb) binding site [polypeptide binding]; other site
329726011830	Domain of unknown function DUF11; Region: DUF11; cl17728
329726011831	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726011832	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726011833	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726011834	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
329726011835	GAF domain; Region: GAF; cl17456
329726011836	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726011837	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726011838	DNA binding residues [nucleotide binding]
329726011839	dimerization interface [polypeptide binding]; other site
329726011840	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
329726011841	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
329726011842	active site residue [active]
329726011843	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
329726011844	active site residue [active]
329726011845	TPR repeat; Region: TPR_11; pfam13414
329726011846	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011847	binding surface
329726011848	TPR motif; other site
329726011849	Protein of unknown function, DUF258; Region: DUF258; pfam03193
329726011850	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726011851	structural tetrad; other site
329726011852	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726011853	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726011854	structural tetrad; other site
329726011855	Archaeal ATPase; Region: Arch_ATPase; pfam01637
329726011856	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
329726011857	putative active site [active]
329726011858	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726011859	structural tetrad; other site
329726011860	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726011861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
329726011862	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
329726011863	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
329726011864	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
329726011865	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
329726011866	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
329726011867	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
329726011868	ligand binding site [chemical binding]; other site
329726011869	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
329726011870	Rab subfamily motif 1 (RabSF1); other site
329726011871	G1 box; other site
329726011872	GTP/Mg2+ binding site [chemical binding]; other site
329726011873	Rab subfamily motif 2 (RabSF2); other site
329726011874	Switch I region; other site
329726011875	G2 box; other site
329726011876	effector interaction site; other site
329726011877	GDI interaction site; other site
329726011878	Rab family motif 1 (RabF1); other site
329726011879	GEF interaction site [polypeptide binding]; other site
329726011880	Rab family motif 2 (RabF2); other site
329726011881	G3 box; other site
329726011882	Switch II region; other site
329726011883	Rab family motif 3 (RabF3); other site
329726011884	Rab family motif 4 (RabF4); other site
329726011885	Rab family motif 5 (RabF5); other site
329726011886	Rab subfamily motif 3 (RabSF3); other site
329726011887	G4 box; other site
329726011888	G5 box; other site
329726011889	Rab subfamily motif 4 (RabSF4); other site
329726011890	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
329726011891	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011892	TPR motif; other site
329726011893	binding surface
329726011894	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011895	binding surface
329726011896	TPR motif; other site
329726011897	TPR repeat; Region: TPR_11; pfam13414
329726011898	TPR repeat; Region: TPR_11; pfam13414
329726011899	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011900	binding surface
329726011901	TPR motif; other site
329726011902	TPR repeat; Region: TPR_11; pfam13414
329726011903	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011904	binding surface
329726011905	TPR motif; other site
329726011906	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011907	binding surface
329726011908	TPR motif; other site
329726011909	TPR repeat; Region: TPR_11; pfam13414
329726011910	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011911	TPR motif; other site
329726011912	binding surface
329726011913	TPR repeat; Region: TPR_11; pfam13414
329726011914	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011915	TPR repeat; Region: TPR_11; pfam13414
329726011916	binding surface
329726011917	TPR motif; other site
329726011918	TPR repeat; Region: TPR_11; pfam13414
329726011919	TPR repeat; Region: TPR_11; pfam13414
329726011920	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011921	binding surface
329726011922	TPR motif; other site
329726011923	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011924	binding surface
329726011925	TPR motif; other site
329726011926	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726011927	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011928	binding surface
329726011929	TPR motif; other site
329726011930	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011931	TPR motif; other site
329726011932	binding surface
329726011933	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011934	binding surface
329726011935	TPR motif; other site
329726011936	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011937	binding surface
329726011938	TPR motif; other site
329726011939	TPR repeat; Region: TPR_11; pfam13414
329726011940	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011941	binding surface
329726011942	TPR repeat; Region: TPR_11; pfam13414
329726011943	TPR motif; other site
329726011944	TPR repeat; Region: TPR_11; pfam13414
329726011945	TPR repeat; Region: TPR_11; pfam13414
329726011946	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011947	TPR motif; other site
329726011948	binding surface
329726011949	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726011950	TPR repeat; Region: TPR_11; pfam13414
329726011951	binding surface
329726011952	TPR motif; other site
329726011953	Cupin domain; Region: Cupin_2; cl17218
329726011954	glutathione S-transferase; Provisional; Region: PRK15113
329726011955	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
329726011956	putative C-terminal domain interface [polypeptide binding]; other site
329726011957	putative GSH binding site (G-site) [chemical binding]; other site
329726011958	putative dimer interface [polypeptide binding]; other site
329726011959	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
329726011960	putative substrate binding pocket (H-site) [chemical binding]; other site
329726011961	putative N-terminal domain interface [polypeptide binding]; other site
329726011962	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
329726011963	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726011964	Walker A motif; other site
329726011965	ATP binding site [chemical binding]; other site
329726011966	Walker B motif; other site
329726011967	The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...; Region: PB1; cl02720
329726011968	PB1 interaction surface [polypeptide binding]; other site
329726011969	arginine finger; other site
329726011970	PB1 interaction site [polypeptide binding]; other site
329726011971	PB1 interaction site [polypeptide binding]; other site
329726011972	PB1 interaction surface [polypeptide binding]; other site
329726011973	PB1 interaction surface [polypeptide binding]; other site
329726011974	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
329726011975	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
329726011976	hypothetical protein; Reviewed; Region: PRK09588
329726011977	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
329726011978	Bacterial sugar transferase; Region: Bac_transf; pfam02397
329726011979	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
329726011980	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726011981	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726011982	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
329726011983	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
329726011984	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
329726011985	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
329726011986	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
329726011987	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
329726011988	ATP-grasp domain; Region: ATP-grasp; pfam02222
329726011989	Ycf46; Provisional; Region: ycf46; CHL00195
329726011990	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726011991	Walker A motif; other site
329726011992	ATP binding site [chemical binding]; other site
329726011993	Walker B motif; other site
329726011994	arginine finger; other site
329726011995	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
329726011996	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
329726011997	putative catalytic residue [active]
329726011998	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
329726011999	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
329726012000	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
329726012001	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
329726012002	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
329726012003	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
329726012004	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
329726012005	catalytic residue [active]
329726012006	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
329726012007	putative active site pocket [active]
329726012008	dimerization interface [polypeptide binding]; other site
329726012009	putative catalytic residue [active]
329726012010	PAS fold; Region: PAS_4; pfam08448
329726012011	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726012012	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726012013	metal binding site [ion binding]; metal-binding site
329726012014	active site
329726012015	I-site; other site
329726012016	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
329726012017	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
329726012018	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
329726012019	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726012020	putative active site [active]
329726012021	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
329726012022	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
329726012023	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
329726012024	XisI protein; Region: XisI; pfam08869
329726012025	XisH protein; Region: XisH; pfam08814
329726012026	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
329726012027	HsdM N-terminal domain; Region: HsdM_N; pfam12161
329726012028	Methyltransferase domain; Region: Methyltransf_26; pfam13659
329726012029	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
329726012030	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726012031	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
329726012032	active site
329726012033	catalytic site [active]
329726012034	substrate binding site [chemical binding]; other site
329726012035	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
329726012036	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
329726012037	putative active site [active]
329726012038	putative NTP binding site [chemical binding]; other site
329726012039	putative nucleic acid binding site [nucleotide binding]; other site
329726012040	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
329726012041	FOG: WD40-like repeat [Function unknown]; Region: COG1520
329726012042	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
329726012043	Response regulator receiver domain; Region: Response_reg; pfam00072
329726012044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012045	active site
329726012046	phosphorylation site [posttranslational modification]
329726012047	intermolecular recognition site; other site
329726012048	dimerization interface [polypeptide binding]; other site
329726012049	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726012050	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726012051	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726012052	dimer interface [polypeptide binding]; other site
329726012053	phosphorylation site [posttranslational modification]
329726012054	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726012055	ATP binding site [chemical binding]; other site
329726012056	Mg2+ binding site [ion binding]; other site
329726012057	G-X-G motif; other site
329726012058	Response regulator receiver domain; Region: Response_reg; pfam00072
329726012059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012060	active site
329726012061	phosphorylation site [posttranslational modification]
329726012062	intermolecular recognition site; other site
329726012063	dimerization interface [polypeptide binding]; other site
329726012064	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726012065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012066	active site
329726012067	phosphorylation site [posttranslational modification]
329726012068	intermolecular recognition site; other site
329726012069	dimerization interface [polypeptide binding]; other site
329726012070	Response regulator receiver domain; Region: Response_reg; pfam00072
329726012071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012072	active site
329726012073	phosphorylation site [posttranslational modification]
329726012074	intermolecular recognition site; other site
329726012075	dimerization interface [polypeptide binding]; other site
329726012076	Heme NO binding associated; Region: HNOBA; pfam07701
329726012077	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726012078	dimer interface [polypeptide binding]; other site
329726012079	phosphorylation site [posttranslational modification]
329726012080	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726012081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726012082	ATP binding site [chemical binding]; other site
329726012083	Mg2+ binding site [ion binding]; other site
329726012084	G-X-G motif; other site
329726012085	Heme NO binding; Region: HNOB; pfam07700
329726012086	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726012087	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726012088	S-adenosylmethionine binding site [chemical binding]; other site
329726012089	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
329726012090	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
329726012091	active site
329726012092	iron coordination sites [ion binding]; other site
329726012093	substrate binding pocket [chemical binding]; other site
329726012094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726012095	AAA domain; Region: AAA_21; pfam13304
329726012096	Walker A/P-loop; other site
329726012097	ATP binding site [chemical binding]; other site
329726012098	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
329726012099	dimer interface [polypeptide binding]; other site
329726012100	active site
329726012101	Schiff base residues; other site
329726012102	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
329726012103	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
329726012104	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
329726012105	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726012106	catalytic residue [active]
329726012107	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
329726012108	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
329726012109	putative active site [active]
329726012110	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
329726012111	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
329726012112	RNB domain; Region: RNB; pfam00773
329726012113	ribosomal protein S18; Region: rps18; CHL00077
329726012114	ribosomal protein L33; Region: rpl33; CHL00104
329726012115	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
329726012116	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
329726012117	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
329726012118	putative NAD(P) binding site [chemical binding]; other site
329726012119	putative substrate binding site [chemical binding]; other site
329726012120	catalytic Zn binding site [ion binding]; other site
329726012121	structural Zn binding site [ion binding]; other site
329726012122	dimer interface [polypeptide binding]; other site
329726012123	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
329726012124	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
329726012125	NADP binding site [chemical binding]; other site
329726012126	active site
329726012127	putative substrate binding site [chemical binding]; other site
329726012128	Protein of unknown function (DUF565); Region: DUF565; pfam04483
329726012129	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
329726012130	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726012131	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726012132	dimer interface [polypeptide binding]; other site
329726012133	phosphorylation site [posttranslational modification]
329726012134	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726012135	ATP binding site [chemical binding]; other site
329726012136	Mg2+ binding site [ion binding]; other site
329726012137	G-X-G motif; other site
329726012138	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726012139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012140	active site
329726012141	phosphorylation site [posttranslational modification]
329726012142	intermolecular recognition site; other site
329726012143	dimerization interface [polypeptide binding]; other site
329726012144	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
329726012145	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726012146	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
329726012147	Walker A/P-loop; other site
329726012148	ATP binding site [chemical binding]; other site
329726012149	Q-loop/lid; other site
329726012150	ABC transporter signature motif; other site
329726012151	Walker B; other site
329726012152	D-loop; other site
329726012153	H-loop/switch region; other site
329726012154	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
329726012155	active site
329726012156	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
329726012157	active site
329726012158	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
329726012159	active site lid residues [active]
329726012160	substrate binding pocket [chemical binding]; other site
329726012161	catalytic residues [active]
329726012162	substrate-Mg2+ binding site; other site
329726012163	aspartate-rich region 1; other site
329726012164	aspartate-rich region 2; other site
329726012165	phytoene desaturase; Region: phytoene_desat; TIGR02731
329726012166	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726012167	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726012168	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726012169	metal binding site [ion binding]; metal-binding site
329726012170	active site
329726012171	I-site; other site
329726012172	tocopherol O-methyltransferase; Region: PLN02244
329726012173	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726012174	S-adenosylmethionine binding site [chemical binding]; other site
329726012175	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
329726012176	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726012177	putative ADP-binding pocket [chemical binding]; other site
329726012178	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
329726012179	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
329726012180	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726012181	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
329726012182	putative ADP-binding pocket [chemical binding]; other site
329726012183	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
329726012184	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726012185	putative ADP-binding pocket [chemical binding]; other site
329726012186	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
329726012187	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
329726012188	inhibitor-cofactor binding pocket; inhibition site
329726012189	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726012190	catalytic residue [active]
329726012191	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
329726012192	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
329726012193	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
329726012194	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726012195	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
329726012196	putative DNA binding site [nucleotide binding]; other site
329726012197	putative Zn2+ binding site [ion binding]; other site
329726012198	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
329726012199	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
329726012200	catalytic residues [active]
329726012201	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
329726012202	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
329726012203	FMN binding site [chemical binding]; other site
329726012204	active site
329726012205	substrate binding site [chemical binding]; other site
329726012206	catalytic residue [active]
329726012207	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
329726012208	SnoaL-like domain; Region: SnoaL_2; pfam12680
329726012209	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
329726012210	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
329726012211	putative ligand binding site [chemical binding]; other site
329726012212	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726012213	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726012214	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726012215	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726012216	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726012217	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
329726012218	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
329726012219	ligand binding site [chemical binding]; other site
329726012220	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
329726012221	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
329726012222	Active site cavity [active]
329726012223	catalytic acid [active]
329726012224	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
329726012225	RibD C-terminal domain; Region: RibD_C; cl17279
329726012226	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
329726012227	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
329726012228	C-terminal peptidase (prc); Region: prc; TIGR00225
329726012229	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
329726012230	protein binding site [polypeptide binding]; other site
329726012231	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
329726012232	Catalytic dyad [active]
329726012233	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726012234	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726012235	magnesium chelatase subunit H; Provisional; Region: PLN03241
329726012236	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
329726012237	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
329726012238	Divergent PAP2 family; Region: DUF212; pfam02681
329726012239	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
329726012240	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
329726012241	substrate binding pocket [chemical binding]; other site
329726012242	chain length determination region; other site
329726012243	substrate-Mg2+ binding site; other site
329726012244	catalytic residues [active]
329726012245	aspartate-rich region 1; other site
329726012246	active site lid residues [active]
329726012247	aspartate-rich region 2; other site
329726012248	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
329726012249	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
329726012250	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
329726012251	homodimer interface [polypeptide binding]; other site
329726012252	NADP binding site [chemical binding]; other site
329726012253	substrate binding site [chemical binding]; other site
329726012254	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
329726012255	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
329726012256	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
329726012257	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
329726012258	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
329726012259	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
329726012260	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
329726012261	homoserine kinase; Provisional; Region: PRK01212
329726012262	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
329726012263	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
329726012264	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
329726012265	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
329726012266	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726012267	Magnesium ion binding site [ion binding]; other site
329726012268	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726012269	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726012270	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
329726012271	active site
329726012272	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
329726012273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726012274	ATP binding site [chemical binding]; other site
329726012275	Mg2+ binding site [ion binding]; other site
329726012276	G-X-G motif; other site
329726012277	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
329726012278	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
329726012279	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
329726012280	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
329726012281	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
329726012282	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
329726012283	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
329726012284	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
329726012285	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
329726012286	Substrate binding site; other site
329726012287	Mg++ binding site; other site
329726012288	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
329726012289	active site
329726012290	substrate binding site [chemical binding]; other site
329726012291	CoA binding site [chemical binding]; other site
329726012292	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726012293	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
329726012294	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
329726012295	active site
329726012296	interdomain interaction site; other site
329726012297	putative metal-binding site [ion binding]; other site
329726012298	nucleotide binding site [chemical binding]; other site
329726012299	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
329726012300	domain I; other site
329726012301	DNA binding groove [nucleotide binding]
329726012302	phosphate binding site [ion binding]; other site
329726012303	domain II; other site
329726012304	domain III; other site
329726012305	nucleotide binding site [chemical binding]; other site
329726012306	catalytic site [active]
329726012307	domain IV; other site
329726012308	Transposase domain (DUF772); Region: DUF772; pfam05598
329726012309	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726012310	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
329726012311	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
329726012312	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
329726012313	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
329726012314	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726012315	Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897
329726012316	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
329726012317	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
329726012318	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726012319	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726012320	ligand binding site [chemical binding]; other site
329726012321	flexible hinge region; other site
329726012322	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
329726012323	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
329726012324	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
329726012325	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
329726012326	active site
329726012327	intersubunit interface [polypeptide binding]; other site
329726012328	catalytic residue [active]
329726012329	Uncharacterized conserved protein [Function unknown]; Region: COG2006
329726012330	Domain of unknown function (DUF362); Region: DUF362; pfam04015
329726012331	Thf1-like protein; Reviewed; Region: PRK13266
329726012332	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
329726012333	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
329726012334	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
329726012335	putative GSH binding site [chemical binding]; other site
329726012336	catalytic residues [active]
329726012337	BolA-like protein; Region: BolA; pfam01722
329726012338	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
329726012339	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
329726012340	active site
329726012341	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
329726012342	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
329726012343	active site
329726012344	(T/H)XGH motif; other site
329726012345	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
329726012346	nudix motif; other site
329726012347	NAD synthetase; Provisional; Region: PRK13981
329726012348	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
329726012349	multimer interface [polypeptide binding]; other site
329726012350	active site
329726012351	catalytic triad [active]
329726012352	protein interface 1 [polypeptide binding]; other site
329726012353	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
329726012354	homodimer interface [polypeptide binding]; other site
329726012355	NAD binding pocket [chemical binding]; other site
329726012356	ATP binding pocket [chemical binding]; other site
329726012357	Mg binding site [ion binding]; other site
329726012358	active-site loop [active]
329726012359	Membrane protein of unknown function; Region: DUF360; cl00850
329726012360	Ion channel; Region: Ion_trans_2; pfam07885
329726012361	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
329726012362	TrkA-N domain; Region: TrkA_N; pfam02254
329726012363	TrkA-C domain; Region: TrkA_C; pfam02080
329726012364	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
329726012365	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
329726012366	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
329726012367	Uncharacterized conserved protein [Function unknown]; Region: COG3339
329726012368	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
329726012369	active site
329726012370	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
329726012371	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726012372	Walker A/P-loop; other site
329726012373	ATP binding site [chemical binding]; other site
329726012374	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
329726012375	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
329726012376	Catalytic site [active]
329726012377	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
329726012378	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
329726012379	substrate binding pocket [chemical binding]; other site
329726012380	chain length determination region; other site
329726012381	substrate-Mg2+ binding site; other site
329726012382	catalytic residues [active]
329726012383	aspartate-rich region 1; other site
329726012384	active site lid residues [active]
329726012385	aspartate-rich region 2; other site
329726012386	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
329726012387	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
329726012388	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
329726012389	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
329726012390	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
329726012391	phosphoribulokinase; Provisional; Region: PRK07429
329726012392	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
329726012393	active site
329726012394	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
329726012395	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
329726012396	active site
329726012397	metal binding site [ion binding]; metal-binding site
329726012398	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
329726012399	homooctamer interface [polypeptide binding]; other site
329726012400	active site
329726012401	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726012402	FtsH Extracellular; Region: FtsH_ext; pfam06480
329726012403	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
329726012404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726012405	Walker A motif; other site
329726012406	ATP binding site [chemical binding]; other site
329726012407	Walker B motif; other site
329726012408	arginine finger; other site
329726012409	Peptidase family M41; Region: Peptidase_M41; pfam01434
329726012410	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
329726012411	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
329726012412	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726012413	Ligand Binding Site [chemical binding]; other site
329726012414	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
329726012415	cytidine deaminase; Validated; Region: PRK08298
329726012416	active site
329726012417	Zn binding site [ion binding]; other site
329726012418	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
329726012419	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726012420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726012421	S-adenosylmethionine binding site [chemical binding]; other site
329726012422	HutD; Region: HutD; cl01532
329726012423	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
329726012424	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
329726012425	RNA binding surface [nucleotide binding]; other site
329726012426	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
329726012427	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726012428	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
329726012429	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
329726012430	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
329726012431	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
329726012432	Na binding site [ion binding]; other site
329726012433	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
329726012434	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
329726012435	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
329726012436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
329726012437	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
329726012438	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726012439	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726012440	metal binding site [ion binding]; metal-binding site
329726012441	active site
329726012442	I-site; other site
329726012443	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726012444	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726012445	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726012446	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726012447	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726012448	Response regulator receiver domain; Region: Response_reg; pfam00072
329726012449	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012450	active site
329726012451	phosphorylation site [posttranslational modification]
329726012452	intermolecular recognition site; other site
329726012453	dimerization interface [polypeptide binding]; other site
329726012454	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
329726012455	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
329726012456	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
329726012457	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
329726012458	ABC-ATPase subunit  interface; other site
329726012459	dimer interface [polypeptide binding]; other site
329726012460	putative PBP binding regions; other site
329726012461	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
329726012462	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
329726012463	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
329726012464	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
329726012465	metal binding site [ion binding]; metal-binding site
329726012466	C factor cell-cell signaling protein; Provisional; Region: PRK09009
329726012467	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
329726012468	NADP binding site [chemical binding]; other site
329726012469	homodimer interface [polypeptide binding]; other site
329726012470	active site
329726012471	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
329726012472	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
329726012473	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
329726012474	DXD motif; other site
329726012475	Cellulose synthase-like protein; Region: PLN02893
329726012476	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
329726012477	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726012478	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
329726012479	surface protease GP63; Provisional; Region: PTZ00337
329726012480	haemagglutination activity domain; Region: Haemagg_act; pfam05860
329726012481	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
329726012482	C-terminal peptidase (prc); Region: prc; TIGR00225
329726012483	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
329726012484	protein binding site [polypeptide binding]; other site
329726012485	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
329726012486	Catalytic dyad [active]
329726012487	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
329726012488	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
329726012489	dimerization interface [polypeptide binding]; other site
329726012490	domain crossover interface; other site
329726012491	redox-dependent activation switch; other site
329726012492	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
329726012493	active site
329726012494	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
329726012495	iron-sulfur cluster [ion binding]; other site
329726012496	[2Fe-2S] cluster binding site [ion binding]; other site
329726012497	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726012498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012499	active site
329726012500	phosphorylation site [posttranslational modification]
329726012501	intermolecular recognition site; other site
329726012502	dimerization interface [polypeptide binding]; other site
329726012503	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726012504	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726012505	metal binding site [ion binding]; metal-binding site
329726012506	active site
329726012507	I-site; other site
329726012508	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726012509	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012510	active site
329726012511	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726012512	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726012513	metal binding site [ion binding]; metal-binding site
329726012514	active site
329726012515	I-site; other site
329726012516	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726012517	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726012518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012519	active site
329726012520	phosphorylation site [posttranslational modification]
329726012521	intermolecular recognition site; other site
329726012522	dimerization interface [polypeptide binding]; other site
329726012523	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726012524	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726012525	metal binding site [ion binding]; metal-binding site
329726012526	active site
329726012527	I-site; other site
329726012528	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726012529	M28 Zn-Peptidases; Region: M28_like_1; cd05640
329726012530	Peptidase family M28; Region: Peptidase_M28; pfam04389
329726012531	metal binding site [ion binding]; metal-binding site
329726012532	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
329726012533	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
329726012534	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726012535	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726012536	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726012537	DNA binding residues [nucleotide binding]
329726012538	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
329726012539	CHAT domain; Region: CHAT; cl17868
329726012540	TIR domain; Region: TIR_2; pfam13676
329726012541	AAA domain; Region: AAA_14; pfam13173
329726012542	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726012543	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726012544	structural tetrad; other site
329726012545	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726012546	structural tetrad; other site
329726012547	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726012548	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
329726012549	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726012550	Helix-turn-helix domain; Region: HTH_18; pfam12833
329726012551	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
329726012552	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
329726012553	DNA binding site [nucleotide binding]
329726012554	active site
329726012555	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
329726012556	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726012557	Coenzyme A binding pocket [chemical binding]; other site
329726012558	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
329726012559	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
329726012560	NAD(P) binding site [chemical binding]; other site
329726012561	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726012562	PAS domain; Region: PAS_9; pfam13426
329726012563	putative active site [active]
329726012564	heme pocket [chemical binding]; other site
329726012565	PAS domain; Region: PAS_9; pfam13426
329726012566	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726012567	putative active site [active]
329726012568	PAS fold; Region: PAS_3; pfam08447
329726012569	heme pocket [chemical binding]; other site
329726012570	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
329726012571	Domain of unknown function (DUF389); Region: DUF389; pfam04087
329726012572	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
329726012573	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
329726012574	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
329726012575	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726012576	Transposase [DNA replication, recombination, and repair]; Region: COG5433
329726012577	Transposase [DNA replication, recombination, and repair]; Region: COG5433
329726012578	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726012579	Protein of unknown function, DUF547; Region: DUF547; pfam04784
329726012580	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
329726012581	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726012582	S-adenosylmethionine binding site [chemical binding]; other site
329726012583	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
329726012584	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
329726012585	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
329726012586	Ferritin-like; Region: Ferritin-like; pfam12902
329726012587	quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906
329726012588	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726012589	FeS/SAM binding site; other site
329726012590	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
329726012591	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
329726012592	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726012593	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
329726012594	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
329726012595	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
329726012596	LDH/MDH dimer interface [polypeptide binding]; other site
329726012597	NAD(P) binding site [chemical binding]; other site
329726012598	substrate binding site [chemical binding]; other site
329726012599	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
329726012600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726012601	S-adenosylmethionine binding site [chemical binding]; other site
329726012602	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
329726012603	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
329726012604	recombinase A; Provisional; Region: recA; PRK09354
329726012605	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
329726012606	hexamer interface [polypeptide binding]; other site
329726012607	Walker A motif; other site
329726012608	ATP binding site [chemical binding]; other site
329726012609	Walker B motif; other site
329726012610	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
329726012611	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726012612	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
329726012613	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726012614	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
329726012615	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726012616	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
329726012617	AAA domain; Region: AAA_30; pfam13604
329726012618	Family description; Region: UvrD_C_2; pfam13538
329726012619	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
329726012620	N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228
329726012621	active site
329726012622	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726012623	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726012624	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
329726012625	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
329726012626	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726012627	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
329726012628	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
329726012629	FtsX-like permease family; Region: FtsX; pfam02687
329726012630	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
329726012631	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
329726012632	Walker A/P-loop; other site
329726012633	ATP binding site [chemical binding]; other site
329726012634	Q-loop/lid; other site
329726012635	ABC transporter signature motif; other site
329726012636	Walker B; other site
329726012637	D-loop; other site
329726012638	H-loop/switch region; other site
329726012639	Herpesvirus UL14-like protein; Region: Herpes_UL14; cl17291
329726012640	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
329726012641	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
329726012642	active site
329726012643	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
329726012644	Peptidase family M50; Region: Peptidase_M50; pfam02163
329726012645	active site
329726012646	putative substrate binding region [chemical binding]; other site
329726012647	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
329726012648	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726012649	Ligand Binding Site [chemical binding]; other site
329726012650	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
329726012651	Photosystem II reaction centre T protein; Region: PsbT; cl11601
329726012652	CHASE3 domain; Region: CHASE3; pfam05227
329726012653	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726012654	dimer interface [polypeptide binding]; other site
329726012655	phosphorylation site [posttranslational modification]
329726012656	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726012657	ATP binding site [chemical binding]; other site
329726012658	Mg2+ binding site [ion binding]; other site
329726012659	G-X-G motif; other site
329726012660	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726012661	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012662	active site
329726012663	phosphorylation site [posttranslational modification]
329726012664	intermolecular recognition site; other site
329726012665	dimerization interface [polypeptide binding]; other site
329726012666	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726012667	DNA binding residues [nucleotide binding]
329726012668	dimerization interface [polypeptide binding]; other site
329726012669	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
329726012670	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726012671	binding surface
329726012672	TPR motif; other site
329726012673	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
329726012674	Protein phosphatase 2C; Region: PP2C; pfam00481
329726012675	active site
329726012676	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726012677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012678	active site
329726012679	phosphorylation site [posttranslational modification]
329726012680	intermolecular recognition site; other site
329726012681	dimerization interface [polypeptide binding]; other site
329726012682	Response regulator receiver domain; Region: Response_reg; pfam00072
329726012683	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012684	active site
329726012685	phosphorylation site [posttranslational modification]
329726012686	intermolecular recognition site; other site
329726012687	dimerization interface [polypeptide binding]; other site
329726012688	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726012689	dimer interface [polypeptide binding]; other site
329726012690	phosphorylation site [posttranslational modification]
329726012691	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726012692	ATP binding site [chemical binding]; other site
329726012693	Mg2+ binding site [ion binding]; other site
329726012694	G-X-G motif; other site
329726012695	Response regulator receiver domain; Region: Response_reg; pfam00072
329726012696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012697	active site
329726012698	phosphorylation site [posttranslational modification]
329726012699	intermolecular recognition site; other site
329726012700	dimerization interface [polypeptide binding]; other site
329726012701	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726012702	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726012703	ATP binding site [chemical binding]; other site
329726012704	Mg2+ binding site [ion binding]; other site
329726012705	G-X-G motif; other site
329726012706	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
329726012707	Mechanosensitive ion channel; Region: MS_channel; pfam00924
329726012708	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726012709	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726012710	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726012711	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726012712	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726012713	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726012714	CHRD domain; Region: CHRD; cl06473
329726012715	A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754
329726012716	CHRD domain; Region: CHRD; cl06473
329726012717	CHRD domain; Region: CHRD; cl06473
329726012718	CHRD domain; Region: CHRD; cl06473
329726012719	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726012720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012721	active site
329726012722	phosphorylation site [posttranslational modification]
329726012723	intermolecular recognition site; other site
329726012724	dimerization interface [polypeptide binding]; other site
329726012725	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726012726	DNA binding residues [nucleotide binding]
329726012727	dimerization interface [polypeptide binding]; other site
329726012728	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
329726012729	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726012730	HAMP domain; Region: HAMP; pfam00672
329726012731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726012732	ATP binding site [chemical binding]; other site
329726012733	Mg2+ binding site [ion binding]; other site
329726012734	G-X-G motif; other site
329726012735	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
329726012736	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
329726012737	putative NAD(P) binding site [chemical binding]; other site
329726012738	putative active site [active]
329726012739	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726012740	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
329726012741	putative ADP-binding pocket [chemical binding]; other site
329726012742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012743	active site
329726012744	phosphorylation site [posttranslational modification]
329726012745	intermolecular recognition site; other site
329726012746	dimerization interface [polypeptide binding]; other site
329726012747	chemotaxis protein CheA; Provisional; Region: PRK10547
329726012748	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
329726012749	putative binding surface; other site
329726012750	active site
329726012751	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
329726012752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726012753	ATP binding site [chemical binding]; other site
329726012754	Mg2+ binding site [ion binding]; other site
329726012755	G-X-G motif; other site
329726012756	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
329726012757	Response regulator receiver domain; Region: Response_reg; pfam00072
329726012758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012759	active site
329726012760	phosphorylation site [posttranslational modification]
329726012761	intermolecular recognition site; other site
329726012762	dimerization interface [polypeptide binding]; other site
329726012763	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
329726012764	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
329726012765	dimer interface [polypeptide binding]; other site
329726012766	putative CheW interface [polypeptide binding]; other site
329726012767	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
329726012768	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
329726012769	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726012770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012771	active site
329726012772	phosphorylation site [posttranslational modification]
329726012773	intermolecular recognition site; other site
329726012774	dimerization interface [polypeptide binding]; other site
329726012775	Response regulator receiver domain; Region: Response_reg; pfam00072
329726012776	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012777	active site
329726012778	phosphorylation site [posttranslational modification]
329726012779	intermolecular recognition site; other site
329726012780	dimerization interface [polypeptide binding]; other site
329726012781	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726012782	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726012783	S-adenosylmethionine binding site [chemical binding]; other site
329726012784	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
329726012785	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726012786	FeS/SAM binding site; other site
329726012787	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
329726012788	Uncharacterized conserved protein [Function unknown]; Region: COG0398
329726012789	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
329726012790	Uncharacterized conserved protein [Function unknown]; Region: COG0398
329726012791	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
329726012792	MAPEG family; Region: MAPEG; pfam01124
329726012793	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726012794	PAS fold; Region: PAS_3; pfam08447
329726012795	putative active site [active]
329726012796	heme pocket [chemical binding]; other site
329726012797	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726012798	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726012799	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726012800	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726012801	metal binding site [ion binding]; metal-binding site
329726012802	active site
329726012803	I-site; other site
329726012804	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726012805	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
329726012806	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
329726012807	dimer interface [polypeptide binding]; other site
329726012808	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726012809	catalytic residue [active]
329726012810	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
329726012811	Homeodomain-like domain; Region: HTH_23; pfam13384
329726012812	Winged helix-turn helix; Region: HTH_29; pfam13551
329726012813	Winged helix-turn helix; Region: HTH_33; pfam13592
329726012814	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726012815	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726012816	S-layer homology domain; Region: SLH; pfam00395
329726012817	S-layer homology domain; Region: SLH; pfam00395
329726012818	Ycf27; Reviewed; Region: orf27; CHL00148
329726012819	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012820	active site
329726012821	phosphorylation site [posttranslational modification]
329726012822	intermolecular recognition site; other site
329726012823	dimerization interface [polypeptide binding]; other site
329726012824	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726012825	DNA binding site [nucleotide binding]
329726012826	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
329726012827	L-lactate permease; Region: Lactate_perm; cl00701
329726012828	L-lactate permease; Region: Lactate_perm; cl00701
329726012829	Chromate transporter; Region: Chromate_transp; pfam02417
329726012830	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
329726012831	Chromate transporter; Region: Chromate_transp; pfam02417
329726012832	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
329726012833	active site
329726012834	phosphate binding residues; other site
329726012835	catalytic residues [active]
329726012836	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
329726012837	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
329726012838	alpha-gamma subunit interface [polypeptide binding]; other site
329726012839	beta-gamma subunit interface [polypeptide binding]; other site
329726012840	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
329726012841	active site
329726012842	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
329726012843	gamma-beta subunit interface [polypeptide binding]; other site
329726012844	alpha-beta subunit interface [polypeptide binding]; other site
329726012845	Protein kinase domain; Region: Pkinase; pfam00069
329726012846	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726012847	active site
329726012848	ATP binding site [chemical binding]; other site
329726012849	substrate binding site [chemical binding]; other site
329726012850	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
329726012851	substrate binding site [chemical binding]; other site
329726012852	activation loop (A-loop); other site
329726012853	activation loop (A-loop); other site
329726012854	AAA ATPase domain; Region: AAA_16; pfam13191
329726012855	Predicted ATPase [General function prediction only]; Region: COG3899
329726012856	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726012857	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726012858	GAF domain; Region: GAF; pfam01590
329726012859	PAS domain S-box; Region: sensory_box; TIGR00229
329726012860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726012861	putative active site [active]
329726012862	heme pocket [chemical binding]; other site
329726012863	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726012864	PAS fold; Region: PAS_3; pfam08447
329726012865	putative active site [active]
329726012866	heme pocket [chemical binding]; other site
329726012867	PAS domain S-box; Region: sensory_box; TIGR00229
329726012868	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726012869	putative active site [active]
329726012870	heme pocket [chemical binding]; other site
329726012871	PAS domain S-box; Region: sensory_box; TIGR00229
329726012872	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726012873	putative active site [active]
329726012874	heme pocket [chemical binding]; other site
329726012875	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726012876	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726012877	putative active site [active]
329726012878	heme pocket [chemical binding]; other site
329726012879	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726012880	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726012881	putative active site [active]
329726012882	heme pocket [chemical binding]; other site
329726012883	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726012884	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726012885	putative active site [active]
329726012886	heme pocket [chemical binding]; other site
329726012887	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726012888	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726012889	putative active site [active]
329726012890	heme pocket [chemical binding]; other site
329726012891	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726012892	putative active site [active]
329726012893	heme pocket [chemical binding]; other site
329726012894	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726012895	dimer interface [polypeptide binding]; other site
329726012896	phosphorylation site [posttranslational modification]
329726012897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726012898	ATP binding site [chemical binding]; other site
329726012899	Mg2+ binding site [ion binding]; other site
329726012900	G-X-G motif; other site
329726012901	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726012902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012903	active site
329726012904	phosphorylation site [posttranslational modification]
329726012905	intermolecular recognition site; other site
329726012906	dimerization interface [polypeptide binding]; other site
329726012907	Response regulator receiver domain; Region: Response_reg; pfam00072
329726012908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012909	active site
329726012910	phosphorylation site [posttranslational modification]
329726012911	intermolecular recognition site; other site
329726012912	dimerization interface [polypeptide binding]; other site
329726012913	PAS domain S-box; Region: sensory_box; TIGR00229
329726012914	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726012915	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
329726012916	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726012917	ATP binding site [chemical binding]; other site
329726012918	Mg2+ binding site [ion binding]; other site
329726012919	G-X-G motif; other site
329726012920	urease subunit alpha; Reviewed; Region: ureC; PRK13207
329726012921	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
329726012922	subunit interactions [polypeptide binding]; other site
329726012923	active site
329726012924	flap region; other site
329726012925	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
329726012926	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726012927	putative active site [active]
329726012928	Homeodomain-like domain; Region: HTH_23; pfam13384
329726012929	Winged helix-turn helix; Region: HTH_29; pfam13551
329726012930	Homeodomain-like domain; Region: HTH_32; pfam13565
329726012931	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726012932	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726012933	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
329726012934	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726012935	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726012936	metal binding site [ion binding]; metal-binding site
329726012937	active site
329726012938	I-site; other site
329726012939	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726012940	Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229
329726012941	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
329726012942	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726012943	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
329726012944	Walker A/P-loop; other site
329726012945	ATP binding site [chemical binding]; other site
329726012946	Q-loop/lid; other site
329726012947	ABC transporter signature motif; other site
329726012948	Walker B; other site
329726012949	D-loop; other site
329726012950	H-loop/switch region; other site
329726012951	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
329726012952	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
329726012953	putative ligand binding site [chemical binding]; other site
329726012954	putative NAD binding site [chemical binding]; other site
329726012955	catalytic site [active]
329726012956	phosphoglucomutase; Region: PLN02307
329726012957	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
329726012958	substrate binding site [chemical binding]; other site
329726012959	dimer interface [polypeptide binding]; other site
329726012960	active site
329726012961	metal binding site [ion binding]; metal-binding site
329726012962	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
329726012963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726012964	NAD(P) binding site [chemical binding]; other site
329726012965	active site
329726012966	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
329726012967	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
329726012968	HIGH motif; other site
329726012969	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
329726012970	active site
329726012971	KMSKS motif; other site
329726012972	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
329726012973	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
329726012974	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
329726012975	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726012976	active site
329726012977	ATP binding site [chemical binding]; other site
329726012978	substrate binding site [chemical binding]; other site
329726012979	activation loop (A-loop); other site
329726012980	AAA ATPase domain; Region: AAA_16; pfam13191
329726012981	Predicted ATPase [General function prediction only]; Region: COG3899
329726012982	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726012983	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726012984	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726012985	dimer interface [polypeptide binding]; other site
329726012986	phosphorylation site [posttranslational modification]
329726012987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726012988	ATP binding site [chemical binding]; other site
329726012989	Mg2+ binding site [ion binding]; other site
329726012990	G-X-G motif; other site
329726012991	Response regulator receiver domain; Region: Response_reg; pfam00072
329726012992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726012993	active site
329726012994	phosphorylation site [posttranslational modification]
329726012995	intermolecular recognition site; other site
329726012996	dimerization interface [polypeptide binding]; other site
329726012997	hypothetical protein; Provisional; Region: PRK04194
329726012998	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
329726012999	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
329726013000	putative dimer interface [polypeptide binding]; other site
329726013001	active site pocket [active]
329726013002	putative cataytic base [active]
329726013003	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
329726013004	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726013005	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726013006	ligand binding site [chemical binding]; other site
329726013007	flexible hinge region; other site
329726013008	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
329726013009	putative switch regulator; other site
329726013010	non-specific DNA interactions [nucleotide binding]; other site
329726013011	DNA binding site [nucleotide binding]
329726013012	sequence specific DNA binding site [nucleotide binding]; other site
329726013013	putative cAMP binding site [chemical binding]; other site
329726013014	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
329726013015	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
329726013016	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726013017	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726013018	catalytic loop [active]
329726013019	iron binding site [ion binding]; other site
329726013020	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
329726013021	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
329726013022	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
329726013023	PsaD; Region: PsaD; cl03639
329726013024	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
329726013025	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726013026	GAF domain; Region: GAF; pfam01590
329726013027	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726013028	dimer interface [polypeptide binding]; other site
329726013029	phosphorylation site [posttranslational modification]
329726013030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726013031	ATP binding site [chemical binding]; other site
329726013032	Mg2+ binding site [ion binding]; other site
329726013033	G-X-G motif; other site
329726013034	MEKHLA domain; Region: MEKHLA; pfam08670
329726013035	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
329726013036	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726013037	Transposase [DNA replication, recombination, and repair]; Region: COG5433
329726013038	Transposase [DNA replication, recombination, and repair]; Region: COG5433
329726013039	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726013040	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726013041	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
329726013042	protein binding site [polypeptide binding]; other site
329726013043	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
329726013044	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726013045	ATP binding site [chemical binding]; other site
329726013046	putative Mg++ binding site [ion binding]; other site
329726013047	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726013048	nucleotide binding region [chemical binding]; other site
329726013049	ATP-binding site [chemical binding]; other site
329726013050	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
329726013051	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
329726013052	ArsC family; Region: ArsC; pfam03960
329726013053	catalytic residue [active]
329726013054	GAF domain; Region: GAF; cl17456
329726013055	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726013056	PAS domain; Region: PAS_9; pfam13426
329726013057	putative active site [active]
329726013058	heme pocket [chemical binding]; other site
329726013059	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726013060	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726013061	metal binding site [ion binding]; metal-binding site
329726013062	active site
329726013063	I-site; other site
329726013064	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726013065	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
329726013066	Cytochrome P450; Region: p450; cl12078
329726013067	Protein of unknown function (DUF2004); Region: DUF2004; pfam09406
329726013068	TIR domain; Region: TIR_2; pfam13676
329726013069	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
329726013070	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
329726013071	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726013072	putative active site [active]
329726013073	adenylosuccinate lyase; Provisional; Region: PRK07380
329726013074	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
329726013075	tetramer interface [polypeptide binding]; other site
329726013076	active site
329726013077	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
329726013078	cyanate hydratase; Validated; Region: PRK02866
329726013079	Protein of unknown function (DUF768); Region: DUF768; pfam05589
329726013080	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
329726013081	oligomer interface [polypeptide binding]; other site
329726013082	active site
329726013083	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
329726013084	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
329726013085	Walker A/P-loop; other site
329726013086	ATP binding site [chemical binding]; other site
329726013087	Q-loop/lid; other site
329726013088	ABC transporter signature motif; other site
329726013089	Walker B; other site
329726013090	D-loop; other site
329726013091	H-loop/switch region; other site
329726013092	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
329726013093	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726013094	dimer interface [polypeptide binding]; other site
329726013095	conserved gate region; other site
329726013096	putative PBP binding loops; other site
329726013097	ABC-ATPase subunit interface; other site
329726013098	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
329726013099	NMT1-like family; Region: NMT1_2; pfam13379
329726013100	Response regulator receiver domain; Region: Response_reg; pfam00072
329726013101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726013102	active site
329726013103	phosphorylation site [posttranslational modification]
329726013104	intermolecular recognition site; other site
329726013105	dimerization interface [polypeptide binding]; other site
329726013106	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726013107	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726013108	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726013109	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
329726013110	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726013111	putative active site [active]
329726013112	heme pocket [chemical binding]; other site
329726013113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726013114	dimer interface [polypeptide binding]; other site
329726013115	phosphorylation site [posttranslational modification]
329726013116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726013117	ATP binding site [chemical binding]; other site
329726013118	Mg2+ binding site [ion binding]; other site
329726013119	G-X-G motif; other site
329726013120	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
329726013121	Ligand binding site; other site
329726013122	Putative Catalytic site; other site
329726013123	DXD motif; other site
329726013124	Protein of unknown function, DUF547; Region: DUF547; pfam04784
329726013125	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
329726013126	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
329726013127	trimer interface [polypeptide binding]; other site
329726013128	active site
329726013129	substrate binding site [chemical binding]; other site
329726013130	CoA binding site [chemical binding]; other site
329726013131	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726013132	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726013133	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726013134	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726013135	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
329726013136	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
329726013137	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726013138	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726013139	active site
329726013140	ATP binding site [chemical binding]; other site
329726013141	substrate binding site [chemical binding]; other site
329726013142	activation loop (A-loop); other site
329726013143	phosphodiesterase YaeI; Provisional; Region: PRK11340
329726013144	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
329726013145	putative active site [active]
329726013146	putative metal binding site [ion binding]; other site
329726013147	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
329726013148	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
329726013149	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
329726013150	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
329726013151	TPP-binding site; other site
329726013152	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
329726013153	PYR/PP interface [polypeptide binding]; other site
329726013154	dimer interface [polypeptide binding]; other site
329726013155	TPP binding site [chemical binding]; other site
329726013156	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
329726013157	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
329726013158	rod shape-determining protein MreC; Provisional; Region: PRK13922
329726013159	rod shape-determining protein MreC; Region: MreC; pfam04085
329726013160	rod shape-determining protein MreB; Provisional; Region: PRK13927
329726013161	MreB and similar proteins; Region: MreB_like; cd10225
329726013162	nucleotide binding site [chemical binding]; other site
329726013163	Mg binding site [ion binding]; other site
329726013164	putative protofilament interaction site [polypeptide binding]; other site
329726013165	RodZ interaction site [polypeptide binding]; other site
329726013166	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
329726013167	dimer interface [polypeptide binding]; other site
329726013168	conserved gate region; other site
329726013169	putative PBP binding loops; other site
329726013170	ABC-ATPase subunit interface; other site
329726013171	Double zinc ribbon; Region: DZR; pfam12773
329726013172	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726013173	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726013174	phosphopeptide binding site; other site
329726013175	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
329726013176	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
329726013177	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
329726013178	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
329726013179	catalytic site [active]
329726013180	subunit interface [polypeptide binding]; other site
329726013181	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726013182	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
329726013183	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
329726013184	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
329726013185	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
329726013186	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
329726013187	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
329726013188	dimerization interface [polypeptide binding]; other site
329726013189	active site
329726013190	metal binding site [ion binding]; metal-binding site
329726013191	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
329726013192	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
329726013193	ParB-like nuclease domain; Region: ParBc; cl02129
329726013194	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
329726013195	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
329726013196	dimerization interface [polypeptide binding]; other site
329726013197	DPS ferroxidase diiron center [ion binding]; other site
329726013198	ion pore; other site
329726013199	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
329726013200	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
329726013201	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
329726013202	active site
329726013203	HAS barrel domain; Region: HAS-barrel; pfam09378
329726013204	Domain of unknown function DUF87; Region: DUF87; pfam01935
329726013205	AAA-like domain; Region: AAA_10; pfam12846
329726013206	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726013207	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726013208	active site
329726013209	ATP binding site [chemical binding]; other site
329726013210	substrate binding site [chemical binding]; other site
329726013211	activation loop (A-loop); other site
329726013212	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
329726013213	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
329726013214	DXD motif; other site
329726013215	Response regulator receiver domain; Region: Response_reg; pfam00072
329726013216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726013217	active site
329726013218	phosphorylation site [posttranslational modification]
329726013219	intermolecular recognition site; other site
329726013220	dimerization interface [polypeptide binding]; other site
329726013221	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726013222	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726013223	metal binding site [ion binding]; metal-binding site
329726013224	active site
329726013225	I-site; other site
329726013226	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726013227	conserved repeat domain; Region: B_ant_repeat; TIGR01451
329726013228	Uncharacterized conserved protein [Function unknown]; Region: COG3268
329726013229	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
329726013230	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
329726013231	Predicted transcriptional regulator [Transcription]; Region: COG3636
329726013232	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
329726013233	trimer interface [polypeptide binding]; other site
329726013234	active site
329726013235	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
329726013236	Y-family of DNA polymerases; Region: PolY; cl12025
329726013237	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
329726013238	ssDNA binding site; other site
329726013239	generic binding surface II; other site
329726013240	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726013241	ATP binding site [chemical binding]; other site
329726013242	putative Mg++ binding site [ion binding]; other site
329726013243	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726013244	nucleotide binding region [chemical binding]; other site
329726013245	ATP-binding site [chemical binding]; other site
329726013246	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726013247	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
329726013248	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726013249	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726013250	phosphopeptide binding site; other site
329726013251	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726013252	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726013253	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726013254	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726013255	metal binding site [ion binding]; metal-binding site
329726013256	active site
329726013257	I-site; other site
329726013258	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726013259	Mechanosensitive ion channel; Region: MS_channel; pfam00924
329726013260	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371
329726013261	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726013262	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013263	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013264	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013265	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013266	Homeodomain-like domain; Region: HTH_23; pfam13384
329726013267	Winged helix-turn helix; Region: HTH_29; pfam13551
329726013268	Winged helix-turn helix; Region: HTH_33; pfam13592
329726013269	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726013270	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726013271	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
329726013272	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
329726013273	AIPR protein; Region: AIPR; pfam10592
329726013274	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
329726013275	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
329726013276	substrate binding site [chemical binding]; other site
329726013277	ATP binding site [chemical binding]; other site
329726013278	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
329726013279	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
329726013280	E-class dimer interface [polypeptide binding]; other site
329726013281	P-class dimer interface [polypeptide binding]; other site
329726013282	active site
329726013283	Cu2+ binding site [ion binding]; other site
329726013284	Zn2+ binding site [ion binding]; other site
329726013285	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726013286	Coenzyme A binding pocket [chemical binding]; other site
329726013287	HPP family; Region: HPP; pfam04982
329726013288	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726013289	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
329726013290	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
329726013291	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
329726013292	Na binding site [ion binding]; other site
329726013293	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
329726013294	S-layer homology domain; Region: SLH; pfam00395
329726013295	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
329726013296	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
329726013297	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726013298	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
329726013299	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726013300	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013301	binding surface
329726013302	TPR motif; other site
329726013303	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726013304	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013305	TPR motif; other site
329726013306	binding surface
329726013307	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726013308	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013309	binding surface
329726013310	TPR motif; other site
329726013311	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726013312	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726013313	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013314	binding surface
329726013315	TPR motif; other site
329726013316	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726013317	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013318	binding surface
329726013319	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726013320	TPR motif; other site
329726013321	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726013322	Uncharacterized conserved protein [Function unknown]; Region: COG4278
329726013323	TIGR04222 domain; Region: near_uncomplex
329726013324	Peptidase family M48; Region: Peptidase_M48; pfam01435
329726013325	GTP-binding protein LepA; Provisional; Region: PRK05433
329726013326	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
329726013327	G1 box; other site
329726013328	putative GEF interaction site [polypeptide binding]; other site
329726013329	GTP/Mg2+ binding site [chemical binding]; other site
329726013330	Switch I region; other site
329726013331	G2 box; other site
329726013332	G3 box; other site
329726013333	Switch II region; other site
329726013334	G4 box; other site
329726013335	G5 box; other site
329726013336	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
329726013337	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
329726013338	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
329726013339	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
329726013340	active site
329726013341	putative DNA-binding cleft [nucleotide binding]; other site
329726013342	dimer interface [polypeptide binding]; other site
329726013343	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
329726013344	active site
329726013345	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
329726013346	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
329726013347	substrate binding site [chemical binding]; other site
329726013348	oxyanion hole (OAH) forming residues; other site
329726013349	trimer interface [polypeptide binding]; other site
329726013350	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
329726013351	putative catalytic site [active]
329726013352	putative phosphate binding site [ion binding]; other site
329726013353	active site
329726013354	metal binding site A [ion binding]; metal-binding site
329726013355	DNA binding site [nucleotide binding]
329726013356	putative AP binding site [nucleotide binding]; other site
329726013357	putative metal binding site B [ion binding]; other site
329726013358	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
329726013359	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726013360	dimer interface [polypeptide binding]; other site
329726013361	phosphorylation site [posttranslational modification]
329726013362	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726013363	ATP binding site [chemical binding]; other site
329726013364	Mg2+ binding site [ion binding]; other site
329726013365	G-X-G motif; other site
329726013366	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726013367	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726013368	active site
329726013369	phosphorylation site [posttranslational modification]
329726013370	intermolecular recognition site; other site
329726013371	dimerization interface [polypeptide binding]; other site
329726013372	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726013373	DNA binding site [nucleotide binding]
329726013374	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
329726013375	EamA-like transporter family; Region: EamA; pfam00892
329726013376	EamA-like transporter family; Region: EamA; pfam00892
329726013377	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
329726013378	TRAM domain; Region: TRAM; pfam01938
329726013379	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
329726013380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726013381	S-adenosylmethionine binding site [chemical binding]; other site
329726013382	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
329726013383	Homeodomain-like domain; Region: HTH_23; pfam13384
329726013384	Winged helix-turn helix; Region: HTH_29; pfam13551
329726013385	Winged helix-turn helix; Region: HTH_33; pfam13592
329726013386	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726013387	MoxR-like ATPases [General function prediction only]; Region: COG0714
329726013388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726013389	Walker A motif; other site
329726013390	ATP binding site [chemical binding]; other site
329726013391	Walker B motif; other site
329726013392	arginine finger; other site
329726013393	MoxR-like ATPases [General function prediction only]; Region: COG0714
329726013394	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726013395	Walker A motif; other site
329726013396	ATP binding site [chemical binding]; other site
329726013397	Walker B motif; other site
329726013398	arginine finger; other site
329726013399	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
329726013400	Protein of unknown function DUF58; Region: DUF58; pfam01882
329726013401	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
329726013402	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
329726013403	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
329726013404	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
329726013405	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726013406	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726013407	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726013408	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
329726013409	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
329726013410	LemA family; Region: LemA; cl00742
329726013411	Repair protein; Region: Repair_PSII; pfam04536
329726013412	Repair protein; Region: Repair_PSII; pfam04536
329726013413	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726013414	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
329726013415	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726013416	putative ADP-binding pocket [chemical binding]; other site
329726013417	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
329726013418	DNA binding residues [nucleotide binding]
329726013419	AAA ATPase domain; Region: AAA_16; pfam13191
329726013420	NACHT domain; Region: NACHT; pfam05729
329726013421	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726013422	active site
329726013423	ATP binding site [chemical binding]; other site
329726013424	substrate binding site [chemical binding]; other site
329726013425	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726013426	activation loop (A-loop); other site
329726013427	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
329726013428	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
329726013429	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
329726013430	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
329726013431	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
329726013432	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
329726013433	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726013434	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726013435	putative active site [active]
329726013436	heme pocket [chemical binding]; other site
329726013437	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726013438	putative active site [active]
329726013439	heme pocket [chemical binding]; other site
329726013440	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726013441	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726013442	dimer interface [polypeptide binding]; other site
329726013443	phosphorylation site [posttranslational modification]
329726013444	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726013445	ATP binding site [chemical binding]; other site
329726013446	Mg2+ binding site [ion binding]; other site
329726013447	G-X-G motif; other site
329726013448	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726013449	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726013450	active site
329726013451	phosphorylation site [posttranslational modification]
329726013452	intermolecular recognition site; other site
329726013453	dimerization interface [polypeptide binding]; other site
329726013454	Response regulator receiver domain; Region: Response_reg; pfam00072
329726013455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726013456	active site
329726013457	phosphorylation site [posttranslational modification]
329726013458	intermolecular recognition site; other site
329726013459	dimerization interface [polypeptide binding]; other site
329726013460	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
329726013461	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
329726013462	NurA domain; Region: NurA; pfam09376
329726013463	Bacterial SH3 domain; Region: SH3_3; pfam08239
329726013464	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
329726013465	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
329726013466	active site
329726013467	metal binding site [ion binding]; metal-binding site
329726013468	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726013469	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
329726013470	Mechanosensitive ion channel; Region: MS_channel; pfam00924
329726013471	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
329726013472	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
329726013473	active site
329726013474	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
329726013475	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
329726013476	iron-sulfur cluster [ion binding]; other site
329726013477	[2Fe-2S] cluster binding site [ion binding]; other site
329726013478	conserved hypothetical protein; Region: TIGR02231
329726013479	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
329726013480	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
329726013481	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
329726013482	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726013483	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726013484	structural tetrad; other site
329726013485	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
329726013486	PemK-like protein; Region: PemK; cl00995
329726013487	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
329726013488	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
329726013489	gamma subunit interface [polypeptide binding]; other site
329726013490	epsilon subunit interface [polypeptide binding]; other site
329726013491	LBP interface [polypeptide binding]; other site
329726013492	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
329726013493	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
329726013494	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
329726013495	alpha subunit interaction interface [polypeptide binding]; other site
329726013496	Walker A motif; other site
329726013497	ATP binding site [chemical binding]; other site
329726013498	Walker B motif; other site
329726013499	inhibitor binding site; inhibition site
329726013500	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
329726013501	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
329726013502	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
329726013503	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
329726013504	homodimer interface [polypeptide binding]; other site
329726013505	substrate-cofactor binding pocket; other site
329726013506	catalytic residue [active]
329726013507	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726013508	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013509	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726013510	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013511	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726013512	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013513	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
329726013514	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
329726013515	Transcriptional regulator [Transcription]; Region: LysR; COG0583
329726013516	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726013517	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
329726013518	dimerization interface [polypeptide binding]; other site
329726013519	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
329726013520	putative catalytic residues [active]
329726013521	MAPEG family; Region: MAPEG; pfam01124
329726013522	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
329726013523	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
329726013524	Moco binding site; other site
329726013525	metal coordination site [ion binding]; other site
329726013526	Domain of unknown function DUF29; Region: DUF29; pfam01724
329726013527	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726013528	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
329726013529	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
329726013530	ADP-ribose binding site [chemical binding]; other site
329726013531	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
329726013532	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
329726013533	putative C-terminal domain interface [polypeptide binding]; other site
329726013534	putative GSH binding site (G-site) [chemical binding]; other site
329726013535	putative dimer interface [polypeptide binding]; other site
329726013536	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
329726013537	N-terminal domain interface [polypeptide binding]; other site
329726013538	dimer interface [polypeptide binding]; other site
329726013539	substrate binding pocket (H-site) [chemical binding]; other site
329726013540	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
329726013541	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726013542	motif II; other site
329726013543	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
329726013544	Predicted membrane protein [Function unknown]; Region: COG2259
329726013545	replicative DNA helicase; Region: DnaB; TIGR00665
329726013546	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
329726013547	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
329726013548	Walker A motif; other site
329726013549	ATP binding site [chemical binding]; other site
329726013550	Walker B motif; other site
329726013551	DNA binding loops [nucleotide binding]
329726013552	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
329726013553	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
329726013554	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
329726013555	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726013556	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726013557	phosphopeptide binding site; other site
329726013558	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
329726013559	Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899
329726013560	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726013561	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726013562	phosphopeptide binding site; other site
329726013563	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726013564	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726013565	active site
329726013566	ATP binding site [chemical binding]; other site
329726013567	substrate binding site [chemical binding]; other site
329726013568	activation loop (A-loop); other site
329726013569	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
329726013570	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
329726013571	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
329726013572	active site
329726013573	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
329726013574	pseudouridine synthase; Region: TIGR00093
329726013575	active site
329726013576	Cobalt transport protein; Region: CbiQ; cl00463
329726013577	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
329726013578	anthranilate synthase component I-like protein; Validated; Region: PRK05940
329726013579	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
329726013580	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
329726013581	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
329726013582	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
329726013583	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
329726013584	catalytic residue [active]
329726013585	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
329726013586	pyrroline-5-carboxylate reductase; Region: PLN02688
329726013587	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
329726013588	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
329726013589	RNase_H superfamily; Region: RNase_H_2; pfam13482
329726013590	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
329726013591	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
329726013592	Walker A/P-loop; other site
329726013593	ATP binding site [chemical binding]; other site
329726013594	Q-loop/lid; other site
329726013595	ABC transporter signature motif; other site
329726013596	Walker B; other site
329726013597	D-loop; other site
329726013598	H-loop/switch region; other site
329726013599	TOBE domain; Region: TOBE_2; pfam08402
329726013600	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
329726013601	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
329726013602	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
329726013603	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
329726013604	active site
329726013605	dimer interface [polypeptide binding]; other site
329726013606	metal binding site [ion binding]; metal-binding site
329726013607	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
329726013608	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726013609	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
329726013610	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
329726013611	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
329726013612	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
329726013613	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
329726013614	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
329726013615	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
329726013616	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
329726013617	Hexamer interface [polypeptide binding]; other site
329726013618	Hexagonal pore residue; other site
329726013619	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
329726013620	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
329726013621	Hexamer interface [polypeptide binding]; other site
329726013622	Hexagonal pore residue; other site
329726013623	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
329726013624	Hexamer/Pentamer interface [polypeptide binding]; other site
329726013625	central pore; other site
329726013626	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
329726013627	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
329726013628	trimer interface [polypeptide binding]; other site
329726013629	active site
329726013630	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
329726013631	putative multimerization interface [polypeptide binding]; other site
329726013632	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
329726013633	putative multimerization interface [polypeptide binding]; other site
329726013634	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
329726013635	putative multimerization interface [polypeptide binding]; other site
329726013636	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
329726013637	putative multimerization interface [polypeptide binding]; other site
329726013638	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
329726013639	putative multimerization interface [polypeptide binding]; other site
329726013640	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
329726013641	putative trimer interface [polypeptide binding]; other site
329726013642	putative CoA binding site [chemical binding]; other site
329726013643	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
329726013644	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
329726013645	Hexamer interface [polypeptide binding]; other site
329726013646	Hexagonal pore residue; other site
329726013647	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
329726013648	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
329726013649	Hexamer interface [polypeptide binding]; other site
329726013650	Hexagonal pore residue; other site
329726013651	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
329726013652	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
329726013653	GDP-binding site [chemical binding]; other site
329726013654	ACT binding site; other site
329726013655	IMP binding site; other site
329726013656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726013657	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726013658	S-adenosylmethionine binding site [chemical binding]; other site
329726013659	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013660	TPR motif; other site
329726013661	TPR repeat; Region: TPR_11; pfam13414
329726013662	binding surface
329726013663	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013664	binding surface
329726013665	TPR motif; other site
329726013666	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726013667	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013668	binding surface
329726013669	TPR motif; other site
329726013670	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013671	binding surface
329726013672	TPR motif; other site
329726013673	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013674	binding surface
329726013675	TPR motif; other site
329726013676	TPR repeat; Region: TPR_11; pfam13414
329726013677	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013678	binding surface
329726013679	TPR motif; other site
329726013680	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013681	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726013682	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013683	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013684	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013685	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013686	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013687	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726013688	Coenzyme A binding pocket [chemical binding]; other site
329726013689	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726013690	Coenzyme A binding pocket [chemical binding]; other site
329726013691	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
329726013692	active site
329726013693	dimer interfaces [polypeptide binding]; other site
329726013694	catalytic residues [active]
329726013695	putative lipid kinase; Reviewed; Region: PRK00861
329726013696	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
329726013697	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
329726013698	putative substrate translocation pore; other site
329726013699	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
329726013700	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
329726013701	RNA binding activity-knot of a chromodomain; Region: Tudor-knot; pfam11717
329726013702	Protein of unknown function (DUF952); Region: DUF952; pfam06108
329726013703	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
329726013704	nudix motif; other site
329726013705	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
329726013706	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
329726013707	active site
329726013708	catalytic site [active]
329726013709	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
329726013710	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726013711	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
329726013712	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
329726013713	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726013714	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726013715	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
329726013716	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726013717	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726013718	Coenzyme A binding pocket [chemical binding]; other site
329726013719	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
329726013720	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
329726013721	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
329726013722	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
329726013723	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
329726013724	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
329726013725	ATP-grasp domain; Region: ATP-grasp_4; cl17255
329726013726	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
329726013727	IMP binding site; other site
329726013728	dimer interface [polypeptide binding]; other site
329726013729	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
329726013730	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
329726013731	TM-ABC transporter signature motif; other site
329726013732	Transposase IS200 like; Region: Y1_Tnp; pfam01797
329726013733	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
329726013734	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
329726013735	Ligand Binding Site [chemical binding]; other site
329726013736	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
329726013737	16S/18S rRNA binding site [nucleotide binding]; other site
329726013738	S13e-L30e interaction site [polypeptide binding]; other site
329726013739	25S rRNA binding site [nucleotide binding]; other site
329726013740	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
329726013741	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
329726013742	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
329726013743	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
329726013744	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
329726013745	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726013746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726013747	S-adenosylmethionine binding site [chemical binding]; other site
329726013748	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
329726013749	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
329726013750	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
329726013751	active site
329726013752	Zn binding site [ion binding]; other site
329726013753	DDE domain; Region: DDE_Tnp_IS240; pfam13610
329726013754	Caspase domain; Region: Peptidase_C14; pfam00656
329726013755	AAA ATPase domain; Region: AAA_16; pfam13191
329726013756	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
329726013757	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
329726013758	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
329726013759	catalytic triad [active]
329726013760	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
329726013761	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
329726013762	Zn2+ binding site [ion binding]; other site
329726013763	Mg2+ binding site [ion binding]; other site
329726013764	Uncharacterized conserved protein [Function unknown]; Region: COG3791
329726013765	FOG: CBS domain [General function prediction only]; Region: COG0517
329726013766	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
329726013767	FOG: CBS domain [General function prediction only]; Region: COG0517
329726013768	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
329726013769	Recombinase; Region: Recombinase; pfam07508
329726013770	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726013771	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726013772	catalytic loop [active]
329726013773	iron binding site [ion binding]; other site
329726013774	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
329726013775	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
329726013776	catalytic residues [active]
329726013777	FOG: CBS domain [General function prediction only]; Region: COG0517
329726013778	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
329726013779	CP12 domain; Region: CP12; cl14670
329726013780	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726013781	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726013782	TPR repeat; Region: TPR_11; pfam13414
329726013783	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013784	binding surface
329726013785	TPR motif; other site
329726013786	TPR repeat; Region: TPR_11; pfam13414
329726013787	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
329726013788	binding surface
329726013789	TPR motif; other site
329726013790	Ycf46; Provisional; Region: ycf46; CHL00195
329726013791	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726013792	Walker A motif; other site
329726013793	ATP binding site [chemical binding]; other site
329726013794	Walker B motif; other site
329726013795	arginine finger; other site
329726013796	Outer membrane efflux protein; Region: OEP; pfam02321
329726013797	Outer membrane efflux protein; Region: OEP; pfam02321
329726013798	CHAT domain; Region: CHAT; pfam12770
329726013799	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726013800	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726013801	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726013802	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726013803	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726013804	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013805	binding surface
329726013806	TPR motif; other site
329726013807	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726013808	putative active site [active]
329726013809	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
329726013810	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
329726013811	dimer interface [polypeptide binding]; other site
329726013812	putative anticodon binding site; other site
329726013813	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
329726013814	motif 1; other site
329726013815	active site
329726013816	motif 2; other site
329726013817	motif 3; other site
329726013818	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
329726013819	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
329726013820	active site
329726013821	NTP binding site [chemical binding]; other site
329726013822	metal binding triad [ion binding]; metal-binding site
329726013823	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
329726013824	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
329726013825	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726013826	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013827	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726013828	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013829	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726013830	Tetratricopeptide repeat; Region: TPR_16; pfam13432
329726013831	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013832	binding surface
329726013833	TPR motif; other site
329726013834	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726013835	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726013836	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726013837	AAA ATPase domain; Region: AAA_16; pfam13191
329726013838	NACHT domain; Region: NACHT; pfam05729
329726013839	WD domain, G-beta repeat; Region: WD40; pfam00400
329726013840	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726013841	structural tetrad; other site
329726013842	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726013843	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726013844	structural tetrad; other site
329726013845	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726013846	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726013847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726013848	S-adenosylmethionine binding site [chemical binding]; other site
329726013849	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726013850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726013851	S-adenosylmethionine binding site [chemical binding]; other site
329726013852	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
329726013853	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
329726013854	Bacterial sugar transferase; Region: Bac_transf; pfam02397
329726013855	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726013856	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726013857	active site
329726013858	ATP binding site [chemical binding]; other site
329726013859	substrate binding site [chemical binding]; other site
329726013860	activation loop (A-loop); other site
329726013861	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726013862	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726013863	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726013864	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726013865	SprT-like family; Region: SprT-like; pfam10263
329726013866	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
329726013867	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726013868	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726013869	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726013870	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726013871	DNA binding residues [nucleotide binding]
329726013872	recombinase A; Provisional; Region: recA; PRK09354
329726013873	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
329726013874	hexamer interface [polypeptide binding]; other site
329726013875	Walker A motif; other site
329726013876	ATP binding site [chemical binding]; other site
329726013877	Walker B motif; other site
329726013878	Uncharacterized conserved protein [Function unknown]; Region: COG2135
329726013879	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
329726013880	active site
329726013881	DNA polymerase IV; Validated; Region: PRK02406
329726013882	DNA binding site [nucleotide binding]
329726013883	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
329726013884	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726013885	active site
329726013886	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
329726013887	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
329726013888	putative C-terminal domain interface [polypeptide binding]; other site
329726013889	putative GSH binding site (G-site) [chemical binding]; other site
329726013890	putative dimer interface [polypeptide binding]; other site
329726013891	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
329726013892	dimer interface [polypeptide binding]; other site
329726013893	N-terminal domain interface [polypeptide binding]; other site
329726013894	putative substrate binding pocket (H-site) [chemical binding]; other site
329726013895	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726013896	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
329726013897	Nitrogen regulatory protein P-II; Region: P-II; smart00938
329726013898	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
329726013899	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
329726013900	dimer interface [polypeptide binding]; other site
329726013901	decamer (pentamer of dimers) interface [polypeptide binding]; other site
329726013902	catalytic triad [active]
329726013903	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
329726013904	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
329726013905	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
329726013906	catalytic site [active]
329726013907	G-X2-G-X-G-K; other site
329726013908	hypothetical protein; Provisional; Region: PRK04323
329726013909	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
329726013910	Domain of unknown function (DUF814); Region: DUF814; pfam05670
329726013911	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
329726013912	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
329726013913	anti sigma factor interaction site; other site
329726013914	regulatory phosphorylation site [posttranslational modification]; other site
329726013915	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726013916	Protein of unknown function (DUF721); Region: DUF721; pfam05258
329726013917	TPR repeat; Region: TPR_11; pfam13414
329726013918	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013919	binding surface
329726013920	TPR motif; other site
329726013921	TPR repeat; Region: TPR_11; pfam13414
329726013922	TPR repeat; Region: TPR_11; pfam13414
329726013923	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726013924	binding surface
329726013925	TPR motif; other site
329726013926	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
329726013927	putative nucleotide binding site [chemical binding]; other site
329726013928	uridine monophosphate binding site [chemical binding]; other site
329726013929	homohexameric interface [polypeptide binding]; other site
329726013930	ribosome recycling factor; Reviewed; Region: frr; PRK00083
329726013931	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
329726013932	hinge region; other site
329726013933	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
329726013934	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726013935	Uncharacterized conserved protein [Function unknown]; Region: COG0397
329726013936	hypothetical protein; Validated; Region: PRK00029
329726013937	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
329726013938	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
329726013939	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
329726013940	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
329726013941	ligand binding site [chemical binding]; other site
329726013942	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
329726013943	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
329726013944	twin arginine translocase protein A; Provisional; Region: tatA; PRK14857
329726013945	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
329726013946	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
329726013947	putative active site [active]
329726013948	catalytic residue [active]
329726013949	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726013950	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726013951	catalytic loop [active]
329726013952	iron binding site [ion binding]; other site
329726013953	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
329726013954	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726013955	FeS/SAM binding site; other site
329726013956	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
329726013957	Helix-turn-helix domain; Region: HTH_18; pfam12833
329726013958	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726013959	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726013960	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264
329726013961	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
329726013962	putative catalytic site [active]
329726013963	putative phosphate binding site [ion binding]; other site
329726013964	putative metal binding site [ion binding]; other site
329726013965	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
329726013966	transketolase; Region: PLN02790
329726013967	TPP-binding site [chemical binding]; other site
329726013968	dimer interface [polypeptide binding]; other site
329726013969	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
329726013970	PYR/PP interface [polypeptide binding]; other site
329726013971	dimer interface [polypeptide binding]; other site
329726013972	TPP binding site [chemical binding]; other site
329726013973	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
329726013974	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
329726013975	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
329726013976	dimer interface [polypeptide binding]; other site
329726013977	active site
329726013978	acyl carrier protein; Provisional; Region: acpP; PRK00982
329726013979	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
329726013980	TAP-like protein; Region: Abhydrolase_4; pfam08386
329726013981	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
329726013982	Cysteine-rich domain; Region: CCG; pfam02754
329726013983	Cysteine-rich domain; Region: CCG; pfam02754
329726013984	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726013985	active site
329726013986	ATP binding site [chemical binding]; other site
329726013987	substrate binding site [chemical binding]; other site
329726013988	activation loop (A-loop); other site
329726013989	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726013990	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726013991	dimer interface [polypeptide binding]; other site
329726013992	phosphorylation site [posttranslational modification]
329726013993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726013994	ATP binding site [chemical binding]; other site
329726013995	Mg2+ binding site [ion binding]; other site
329726013996	G-X-G motif; other site
329726013997	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726013998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726013999	active site
329726014000	phosphorylation site [posttranslational modification]
329726014001	intermolecular recognition site; other site
329726014002	excinuclease ABC subunit B; Provisional; Region: PRK05298
329726014003	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726014004	ATP binding site [chemical binding]; other site
329726014005	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726014006	nucleotide binding region [chemical binding]; other site
329726014007	ATP-binding site [chemical binding]; other site
329726014008	Ultra-violet resistance protein B; Region: UvrB; pfam12344
329726014009	UvrB/uvrC motif; Region: UVR; pfam02151
329726014010	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
329726014011	active site
329726014012	catalytic site [active]
329726014013	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
329726014014	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
329726014015	dimer interface [polypeptide binding]; other site
329726014016	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
329726014017	ABC-2 type transporter; Region: ABC2_membrane; cl17235
329726014018	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726014019	dimer interface [polypeptide binding]; other site
329726014020	phosphorylation site [posttranslational modification]
329726014021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726014022	ATP binding site [chemical binding]; other site
329726014023	Mg2+ binding site [ion binding]; other site
329726014024	G-X-G motif; other site
329726014025	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726014026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726014027	active site
329726014028	phosphorylation site [posttranslational modification]
329726014029	intermolecular recognition site; other site
329726014030	dimerization interface [polypeptide binding]; other site
329726014031	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726014032	DNA binding site [nucleotide binding]
329726014033	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
329726014034	ribonuclease Z; Region: RNase_Z; TIGR02651
329726014035	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726014036	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726014037	binding surface
329726014038	TPR motif; other site
329726014039	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726014040	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726014041	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726014042	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726014043	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
329726014044	putative ADP-binding pocket [chemical binding]; other site
329726014045	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726014046	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726014047	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726014048	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726014049	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
329726014050	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726014051	FeS/SAM binding site; other site
329726014052	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
329726014053	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
329726014054	dihydrodipicolinate reductase; Provisional; Region: PRK00048
329726014055	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
329726014056	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
329726014057	photosystem II reaction center protein Psb28; Provisional; Region: PRK13612
329726014058	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
329726014059	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
329726014060	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
329726014061	protein binding site [polypeptide binding]; other site
329726014062	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
329726014063	Catalytic dyad [active]
329726014064	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726014065	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726014066	ligand binding site [chemical binding]; other site
329726014067	flexible hinge region; other site
329726014068	ketol-acid reductoisomerase; Provisional; Region: PRK05479
329726014069	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
329726014070	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
329726014071	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
329726014072	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
329726014073	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
329726014074	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
329726014075	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
329726014076	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
329726014077	active site
329726014078	catalytic triad [active]
329726014079	oxyanion hole [active]
329726014080	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
329726014081	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
329726014082	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
329726014083	acyl-activating enzyme (AAE) consensus motif; other site
329726014084	putative AMP binding site [chemical binding]; other site
329726014085	putative active site [active]
329726014086	putative CoA binding site [chemical binding]; other site
329726014087	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726014088	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014089	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014090	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014091	magnesium chelatase subunit H; Provisional; Region: PRK12493
329726014092	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
329726014093	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
329726014094	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
329726014095	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
329726014096	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726014097	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726014098	phosphopeptide binding site; other site
329726014099	PAS domain S-box; Region: sensory_box; TIGR00229
329726014100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726014101	PAS fold; Region: PAS_3; pfam08447
329726014102	putative active site [active]
329726014103	heme pocket [chemical binding]; other site
329726014104	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726014105	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726014106	metal binding site [ion binding]; metal-binding site
329726014107	active site
329726014108	I-site; other site
329726014109	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726014110	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
329726014111	active site
329726014112	Peptidase family M50; Region: Peptidase_M50; pfam02163
329726014113	putative substrate binding region [chemical binding]; other site
329726014114	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
329726014115	FOG: CBS domain [General function prediction only]; Region: COG0517
329726014116	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
329726014117	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
329726014118	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
329726014119	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726014120	FeS/SAM binding site; other site
329726014121	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
329726014122	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
329726014123	GSH binding site [chemical binding]; other site
329726014124	catalytic residues [active]
329726014125	glutathione synthetase; Provisional; Region: PRK05246
329726014126	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
329726014127	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
329726014128	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
329726014129	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
329726014130	NAD binding site [chemical binding]; other site
329726014131	homodimer interface [polypeptide binding]; other site
329726014132	active site
329726014133	substrate binding site [chemical binding]; other site
329726014134	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
329726014135	Uncharacterized conserved protein [Function unknown]; Region: COG4279
329726014136	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
329726014137	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
329726014138	TPR repeat; Region: TPR_11; pfam13414
329726014139	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726014140	binding surface
329726014141	TPR motif; other site
329726014142	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
329726014143	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
329726014144	active site
329726014145	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
329726014146	active site
329726014147	catalytic residues [active]
329726014148	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
329726014149	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726014150	ATP binding site [chemical binding]; other site
329726014151	putative Mg++ binding site [ion binding]; other site
329726014152	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726014153	nucleotide binding region [chemical binding]; other site
329726014154	ATP-binding site [chemical binding]; other site
329726014155	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
329726014156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
329726014157	HRDC domain; Region: HRDC; pfam00570
329726014158	Winged helix-turn helix; Region: HTH_33; pfam13592
329726014159	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726014160	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
329726014161	MutS domain I; Region: MutS_I; pfam01624
329726014162	MutS domain II; Region: MutS_II; pfam05188
329726014163	MutS domain III; Region: MutS_III; pfam05192
329726014164	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
329726014165	Walker A/P-loop; other site
329726014166	ATP binding site [chemical binding]; other site
329726014167	Q-loop/lid; other site
329726014168	ABC transporter signature motif; other site
329726014169	Walker B; other site
329726014170	D-loop; other site
329726014171	H-loop/switch region; other site
329726014172	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
329726014173	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
329726014174	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
329726014175	DHH family; Region: DHH; pfam01368
329726014176	DHHA1 domain; Region: DHHA1; pfam02272
329726014177	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
329726014178	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
329726014179	FtsX-like permease family; Region: FtsX; pfam02687
329726014180	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
329726014181	FtsX-like permease family; Region: FtsX; pfam02687
329726014182	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
329726014183	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
329726014184	Walker A/P-loop; other site
329726014185	ATP binding site [chemical binding]; other site
329726014186	Q-loop/lid; other site
329726014187	ABC transporter signature motif; other site
329726014188	Walker B; other site
329726014189	D-loop; other site
329726014190	H-loop/switch region; other site
329726014191	Protein of unknown function (DUF445); Region: DUF445; pfam04286
329726014192	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
329726014193	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
329726014194	Walker A/P-loop; other site
329726014195	ATP binding site [chemical binding]; other site
329726014196	Q-loop/lid; other site
329726014197	ABC transporter signature motif; other site
329726014198	Walker B; other site
329726014199	D-loop; other site
329726014200	H-loop/switch region; other site
329726014201	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
329726014202	active site
329726014203	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
329726014204	ABC1 family; Region: ABC1; cl17513
329726014205	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
329726014206	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
329726014207	16S rRNA methyltransferase B; Provisional; Region: PRK14901
329726014208	NusB family; Region: NusB; pfam01029
329726014209	putative RNA binding site [nucleotide binding]; other site
329726014210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726014211	S-adenosylmethionine binding site [chemical binding]; other site
329726014212	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
329726014213	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726014214	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726014215	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726014216	binding surface
329726014217	TPR motif; other site
329726014218	TPR repeat; Region: TPR_11; pfam13414
329726014219	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
329726014220	ornithine carbamoyltransferase; Provisional; Region: PRK00779
329726014221	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
329726014222	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
329726014223	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
329726014224	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
329726014225	Protein of unknown function (DUF512); Region: DUF512; pfam04459
329726014226	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726014227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726014228	active site
329726014229	dimerization interface [polypeptide binding]; other site
329726014230	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726014231	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726014232	metal binding site [ion binding]; metal-binding site
329726014233	active site
329726014234	I-site; other site
329726014235	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726014236	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
329726014237	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
329726014238	substrate binding pocket [chemical binding]; other site
329726014239	membrane-bound complex binding site; other site
329726014240	hinge residues; other site
329726014241	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
329726014242	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
329726014243	Stage II sporulation protein; Region: SpoIID; pfam08486
329726014244	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
329726014245	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
329726014246	Domain of unknown function DUF20; Region: UPF0118; pfam01594
329726014247	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
329726014248	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
329726014249	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
329726014250	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
329726014251	P loop; other site
329726014252	Nucleotide binding site [chemical binding]; other site
329726014253	DTAP/Switch II; other site
329726014254	Switch I; other site
329726014255	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
329726014256	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
329726014257	NAD(P) binding site [chemical binding]; other site
329726014258	homotetramer interface [polypeptide binding]; other site
329726014259	homodimer interface [polypeptide binding]; other site
329726014260	active site
329726014261	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
329726014262	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
329726014263	short chain dehydrogenase; Provisional; Region: PRK07454
329726014264	classical (c) SDRs; Region: SDR_c; cd05233
329726014265	NAD(P) binding site [chemical binding]; other site
329726014266	active site
329726014267	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
329726014268	homodecamer interface [polypeptide binding]; other site
329726014269	GTP cyclohydrolase I; Provisional; Region: PLN03044
329726014270	active site
329726014271	putative catalytic site residues [active]
329726014272	zinc binding site [ion binding]; other site
329726014273	GTP-CH-I/GFRP interaction surface; other site
329726014274	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726014275	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014276	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014277	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014278	Response regulator receiver domain; Region: Response_reg; pfam00072
329726014279	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726014280	active site
329726014281	phosphorylation site [posttranslational modification]
329726014282	intermolecular recognition site; other site
329726014283	dimerization interface [polypeptide binding]; other site
329726014284	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726014285	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726014286	metal binding site [ion binding]; metal-binding site
329726014287	active site
329726014288	I-site; other site
329726014289	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
329726014290	CHASE2 domain; Region: CHASE2; pfam05226
329726014291	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726014292	dimer interface [polypeptide binding]; other site
329726014293	phosphorylation site [posttranslational modification]
329726014294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726014295	ATP binding site [chemical binding]; other site
329726014296	Mg2+ binding site [ion binding]; other site
329726014297	G-X-G motif; other site
329726014298	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
329726014299	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726014300	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
329726014301	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726014302	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726014303	binding surface
329726014304	TPR motif; other site
329726014305	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726014306	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726014307	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726014308	TPR motif; other site
329726014309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
329726014310	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
329726014311	active site
329726014312	substrate binding pocket [chemical binding]; other site
329726014313	dimer interface [polypeptide binding]; other site
329726014314	RTX toxin acyltransferase family; Region: HlyC; pfam02794
329726014315	RTX toxin acyltransferase family; Region: HlyC; pfam02794
329726014316	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726014317	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726014318	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
329726014319	Mechanosensitive ion channel; Region: MS_channel; pfam00924
329726014320	Mechanosensitive ion channel; Region: MS_channel; pfam00924
329726014321	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
329726014322	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
329726014323	DDE superfamily endonuclease; Region: DDE_5; cl17874
329726014324	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726014325	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726014326	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
329726014327	A new structural DNA glycosylase; Region: AlkD_like; cd06561
329726014328	active site
329726014329	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
329726014330	DNA repair protein RadA; Provisional; Region: PRK11823
329726014331	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
329726014332	Walker A motif/ATP binding site; other site
329726014333	ATP binding site [chemical binding]; other site
329726014334	Walker B motif; other site
329726014335	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
329726014336	Ycf27; Reviewed; Region: orf27; CHL00148
329726014337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726014338	active site
329726014339	phosphorylation site [posttranslational modification]
329726014340	intermolecular recognition site; other site
329726014341	dimerization interface [polypeptide binding]; other site
329726014342	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726014343	DNA binding site [nucleotide binding]
329726014344	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726014345	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726014346	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726014347	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
329726014348	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
329726014349	iron-sulfur cluster [ion binding]; other site
329726014350	[2Fe-2S] cluster binding site [ion binding]; other site
329726014351	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726014352	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726014353	ligand binding site [chemical binding]; other site
329726014354	flexible hinge region; other site
329726014355	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726014356	Walker A motif; other site
329726014357	ATP binding site [chemical binding]; other site
329726014358	Walker B motif; other site
329726014359	arginine finger; other site
329726014360	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
329726014361	4Fe-4S binding domain; Region: Fer4_5; pfam12801
329726014362	4Fe-4S binding domain; Region: Fer4_5; pfam12801
329726014363	FOG: CBS domain [General function prediction only]; Region: COG0517
329726014364	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
329726014365	FOG: CBS domain [General function prediction only]; Region: COG0517
329726014366	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
329726014367	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726014368	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726014369	dimer interface [polypeptide binding]; other site
329726014370	phosphorylation site [posttranslational modification]
329726014371	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726014372	ATP binding site [chemical binding]; other site
329726014373	Mg2+ binding site [ion binding]; other site
329726014374	G-X-G motif; other site
329726014375	Response regulator receiver domain; Region: Response_reg; pfam00072
329726014376	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726014377	active site
329726014378	phosphorylation site [posttranslational modification]
329726014379	intermolecular recognition site; other site
329726014380	dimerization interface [polypeptide binding]; other site
329726014381	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
329726014382	Catalytic NodB homology domain of uncharacterized chitin deacetylases and hypothetical proteins; Region: CE4_NodB_like_2; cd10958
329726014383	NodB motif; other site
329726014384	putative active site [active]
329726014385	putative catalytic site [active]
329726014386	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726014387	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014388	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014389	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726014390	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014391	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726014392	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014393	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014394	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014395	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
329726014396	FemAB family; Region: FemAB; pfam02388
329726014397	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726014398	Homeodomain-like domain; Region: HTH_23; pfam13384
329726014399	Winged helix-turn helix; Region: HTH_29; pfam13551
329726014400	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726014401	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726014402	Protein of unknown function (DUF552); Region: DUF552; cl00775
329726014403	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726014404	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726014405	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726014406	GAF domain; Region: GAF; pfam01590
329726014407	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726014408	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726014409	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726014410	GAF domain; Region: GAF; pfam01590
329726014411	PAS fold; Region: PAS_4; pfam08448
329726014412	PAS domain S-box; Region: sensory_box; TIGR00229
329726014413	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726014414	putative active site [active]
329726014415	heme pocket [chemical binding]; other site
329726014416	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726014417	dimer interface [polypeptide binding]; other site
329726014418	phosphorylation site [posttranslational modification]
329726014419	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726014420	ATP binding site [chemical binding]; other site
329726014421	Mg2+ binding site [ion binding]; other site
329726014422	G-X-G motif; other site
329726014423	Response regulator receiver domain; Region: Response_reg; pfam00072
329726014424	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726014425	active site
329726014426	phosphorylation site [posttranslational modification]
329726014427	intermolecular recognition site; other site
329726014428	dimerization interface [polypeptide binding]; other site
329726014429	Response regulator receiver domain; Region: Response_reg; pfam00072
329726014430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726014431	active site
329726014432	phosphorylation site [posttranslational modification]
329726014433	intermolecular recognition site; other site
329726014434	dimerization interface [polypeptide binding]; other site
329726014435	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
329726014436	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
329726014437	putative active site [active]
329726014438	putative dimer interface [polypeptide binding]; other site
329726014439	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
329726014440	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726014441	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
329726014442	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
329726014443	molecular chaperone DnaK; Provisional; Region: PRK13410
329726014444	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
329726014445	nucleotide binding site [chemical binding]; other site
329726014446	NEF interaction site [polypeptide binding]; other site
329726014447	SBD interface [polypeptide binding]; other site
329726014448	chaperone protein DnaJ; Provisional; Region: PRK14299
329726014449	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
329726014450	HSP70 interaction site [polypeptide binding]; other site
329726014451	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
329726014452	dimer interface [polypeptide binding]; other site
329726014453	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726014454	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014455	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014456	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014457	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014458	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
329726014459	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
329726014460	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
329726014461	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
329726014462	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
329726014463	active site
329726014464	metal binding site [ion binding]; metal-binding site
329726014465	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
329726014466	active site
329726014467	metal binding site [ion binding]; metal-binding site
329726014468	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
329726014469	Double zinc ribbon; Region: DZR; pfam12773
329726014470	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726014471	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726014472	active site
329726014473	ATP binding site [chemical binding]; other site
329726014474	substrate binding site [chemical binding]; other site
329726014475	activation loop (A-loop); other site
329726014476	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726014477	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726014478	active site
329726014479	ATP binding site [chemical binding]; other site
329726014480	substrate binding site [chemical binding]; other site
329726014481	activation loop (A-loop); other site
329726014482	Bacterial SH3 domain; Region: SH3_3; pfam08239
329726014483	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
329726014484	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
329726014485	Probable Catalytic site; other site
329726014486	S-adenosylmethionine synthetase; Validated; Region: PRK05250
329726014487	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
329726014488	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
329726014489	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
329726014490	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
329726014491	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726014492	motif II; other site
329726014493	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726014494	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726014495	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726014496	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726014497	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726014498	GAF domain; Region: GAF; pfam01590
329726014499	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726014500	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726014501	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726014502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726014503	dimer interface [polypeptide binding]; other site
329726014504	phosphorylation site [posttranslational modification]
329726014505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726014506	ATP binding site [chemical binding]; other site
329726014507	Mg2+ binding site [ion binding]; other site
329726014508	G-X-G motif; other site
329726014509	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726014510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726014511	active site
329726014512	phosphorylation site [posttranslational modification]
329726014513	intermolecular recognition site; other site
329726014514	dimerization interface [polypeptide binding]; other site
329726014515	Response regulator receiver domain; Region: Response_reg; pfam00072
329726014516	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726014517	active site
329726014518	phosphorylation site [posttranslational modification]
329726014519	intermolecular recognition site; other site
329726014520	dimerization interface [polypeptide binding]; other site
329726014521	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726014522	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726014523	S-adenosylmethionine binding site [chemical binding]; other site
329726014524	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
329726014525	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
329726014526	active site
329726014527	catalytic triad [active]
329726014528	oxyanion hole [active]
329726014529	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726014530	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
329726014531	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
329726014532	active site
329726014533	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
329726014534	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
329726014535	active site
329726014536	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
329726014537	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
329726014538	putative ADP-binding pocket [chemical binding]; other site
329726014539	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
329726014540	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
329726014541	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726014542	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726014543	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
329726014544	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726014545	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
329726014546	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726014547	Walker A/P-loop; other site
329726014548	ATP binding site [chemical binding]; other site
329726014549	Q-loop/lid; other site
329726014550	ABC transporter signature motif; other site
329726014551	Walker B; other site
329726014552	D-loop; other site
329726014553	H-loop/switch region; other site
329726014554	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
329726014555	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
329726014556	active site
329726014557	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
329726014558	trimer interface [polypeptide binding]; other site
329726014559	active site
329726014560	substrate binding site [chemical binding]; other site
329726014561	CoA binding site [chemical binding]; other site
329726014562	Chain length determinant protein; Region: Wzz; cl15801
329726014563	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
329726014564	Chain length determinant protein; Region: Wzz; cl15801
329726014565	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726014566	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726014567	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726014568	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726014569	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
329726014570	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726014571	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014572	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726014573	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014574	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014575	S-layer homology domain; Region: SLH; pfam00395
329726014576	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
329726014577	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
329726014578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726014579	homodimer interface [polypeptide binding]; other site
329726014580	catalytic residue [active]
329726014581	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
329726014582	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726014583	motif II; other site
329726014584	DNA gyrase subunit A; Validated; Region: PRK05560
329726014585	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
329726014586	CAP-like domain; other site
329726014587	active site
329726014588	primary dimer interface [polypeptide binding]; other site
329726014589	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
329726014590	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
329726014591	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
329726014592	homotrimer interface [polypeptide binding]; other site
329726014593	Walker A motif; other site
329726014594	GTP binding site [chemical binding]; other site
329726014595	Walker B motif; other site
329726014596	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
329726014597	TPR motif; other site
329726014598	binding surface
329726014599	Tetratricopeptide repeat; Region: TPR_16; pfam13432
329726014600	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726014601	binding surface
329726014602	TPR motif; other site
329726014603	TPR repeat; Region: TPR_11; pfam13414
329726014604	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
329726014605	Cupin domain; Region: Cupin_2; cl17218
329726014606	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
329726014607	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
329726014608	Stage II sporulation protein; Region: SpoIID; pfam08486
329726014609	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
329726014610	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
329726014611	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
329726014612	NADP-binding site; other site
329726014613	homotetramer interface [polypeptide binding]; other site
329726014614	substrate binding site [chemical binding]; other site
329726014615	homodimer interface [polypeptide binding]; other site
329726014616	active site
329726014617	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726014618	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
329726014619	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726014620	Walker A/P-loop; other site
329726014621	ATP binding site [chemical binding]; other site
329726014622	Q-loop/lid; other site
329726014623	ABC transporter signature motif; other site
329726014624	Walker B; other site
329726014625	D-loop; other site
329726014626	H-loop/switch region; other site
329726014627	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
329726014628	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
329726014629	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
329726014630	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
329726014631	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
329726014632	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726014633	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726014634	active site
329726014635	ATP binding site [chemical binding]; other site
329726014636	substrate binding site [chemical binding]; other site
329726014637	activation loop (A-loop); other site
329726014638	Predicted esterase [General function prediction only]; Region: COG0400
329726014639	putative hydrolase; Provisional; Region: PRK11460
329726014640	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
329726014641	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
329726014642	putative active site [active]
329726014643	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
329726014644	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
329726014645	tRNA; other site
329726014646	putative tRNA binding site [nucleotide binding]; other site
329726014647	putative NADP binding site [chemical binding]; other site
329726014648	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
329726014649	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
329726014650	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
329726014651	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
329726014652	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
329726014653	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
329726014654	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
329726014655	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
329726014656	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726014657	NAD(P) binding site [chemical binding]; other site
329726014658	active site
329726014659	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
329726014660	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
329726014661	inhibitor-cofactor binding pocket; inhibition site
329726014662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726014663	catalytic residue [active]
329726014664	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
329726014665	active site
329726014666	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
329726014667	dimer interface [polypeptide binding]; other site
329726014668	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
329726014669	Ligand Binding Site [chemical binding]; other site
329726014670	Molecular Tunnel; other site
329726014671	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
329726014672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
329726014673	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
329726014674	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726014675	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726014676	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726014677	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
329726014678	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
329726014679	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
329726014680	extended (e) SDRs; Region: SDR_e; cd08946
329726014681	NAD(P) binding site [chemical binding]; other site
329726014682	active site
329726014683	substrate binding site [chemical binding]; other site
329726014684	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726014685	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726014686	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726014687	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726014688	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726014689	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726014690	S-adenosylmethionine binding site [chemical binding]; other site
329726014691	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726014692	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726014693	S-adenosylmethionine binding site [chemical binding]; other site
329726014694	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
329726014695	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
329726014696	active site
329726014697	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
329726014698	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
329726014699	Hexamer interface [polypeptide binding]; other site
329726014700	Hexagonal pore residue; other site
329726014701	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
329726014702	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
329726014703	purine monophosphate binding site [chemical binding]; other site
329726014704	dimer interface [polypeptide binding]; other site
329726014705	putative catalytic residues [active]
329726014706	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
329726014707	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
329726014708	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
329726014709	Cytochrome P450; Region: p450; cl12078
329726014710	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
329726014711	putative catalytic site [active]
329726014712	putative phosphate binding site [ion binding]; other site
329726014713	putative metal binding site [ion binding]; other site
329726014714	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726014715	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726014716	active site
329726014717	ATP binding site [chemical binding]; other site
329726014718	substrate binding site [chemical binding]; other site
329726014719	activation loop (A-loop); other site
329726014720	Protein of unknown function DUF72; Region: DUF72; pfam01904
329726014721	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
329726014722	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726014723	Walker A/P-loop; other site
329726014724	ATP binding site [chemical binding]; other site
329726014725	Q-loop/lid; other site
329726014726	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
329726014727	ABC transporter signature motif; other site
329726014728	Walker B; other site
329726014729	D-loop; other site
329726014730	ABC transporter; Region: ABC_tran_2; pfam12848
329726014731	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
329726014732	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
329726014733	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
329726014734	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
329726014735	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
329726014736	Mg++ binding site [ion binding]; other site
329726014737	putative catalytic motif [active]
329726014738	putative substrate binding site [chemical binding]; other site
329726014739	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
329726014740	Right handed beta helix region; Region: Beta_helix; pfam13229
329726014741	Right handed beta helix region; Region: Beta_helix; pfam13229
329726014742	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
329726014743	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
329726014744	substrate binding site [chemical binding]; other site
329726014745	glutamase interaction surface [polypeptide binding]; other site
329726014746	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
329726014747	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
329726014748	ligand binding site; other site
329726014749	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
329726014750	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
329726014751	putative active site [active]
329726014752	YdjC motif; other site
329726014753	Mg binding site [ion binding]; other site
329726014754	putative homodimer interface [polypeptide binding]; other site
329726014755	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
329726014756	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
329726014757	B12 binding site [chemical binding]; other site
329726014758	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
329726014759	FeS/SAM binding site; other site
329726014760	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726014761	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
329726014762	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
329726014763	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
329726014764	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
329726014765	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
329726014766	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726014767	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
329726014768	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
329726014769	active site
329726014770	catalytic residues [active]
329726014771	DNA binding site [nucleotide binding]
329726014772	Int/Topo IB signature motif; other site
329726014773	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
329726014774	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
329726014775	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
329726014776	active site
329726014777	metal binding site [ion binding]; metal-binding site
329726014778	AAA domain; Region: AAA_25; pfam13481
329726014779	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
329726014780	Walker A motif; other site
329726014781	ATP binding site [chemical binding]; other site
329726014782	Walker B motif; other site
329726014783	Predicted transcriptional regulator [Transcription]; Region: COG2932
329726014784	Helix-turn-helix; Region: HTH_3; pfam01381
329726014785	sequence-specific DNA binding site [nucleotide binding]; other site
329726014786	salt bridge; other site
329726014787	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
329726014788	Catalytic site [active]
329726014789	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726014790	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726014791	catalytic loop [active]
329726014792	iron binding site [ion binding]; other site
329726014793	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726014794	TPR motif; other site
329726014795	TPR repeat; Region: TPR_11; pfam13414
329726014796	binding surface
329726014797	Phycobilisome protein; Region: Phycobilisome; cl08227
329726014798	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726014799	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726014800	catalytic loop [active]
329726014801	iron binding site [ion binding]; other site
329726014802	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
329726014803	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
329726014804	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
329726014805	V4R domain; Region: V4R; pfam02830
329726014806	Transposase domain (DUF772); Region: DUF772; pfam05598
329726014807	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726014808	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
329726014809	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
329726014810	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
329726014811	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
329726014812	AAA ATPase domain; Region: AAA_16; pfam13191
329726014813	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
329726014814	Walker A motif; other site
329726014815	ATP binding site [chemical binding]; other site
329726014816	Walker B motif; other site
329726014817	Homeodomain-like domain; Region: HTH_23; pfam13384
329726014818	Winged helix-turn helix; Region: HTH_29; pfam13551
329726014819	Homeodomain-like domain; Region: HTH_32; pfam13565
329726014820	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726014821	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726014822	AAA-like domain; Region: AAA_10; pfam12846
329726014823	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
329726014824	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
329726014825	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
329726014826	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
329726014827	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
329726014828	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726014829	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726014830	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726014831	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726014832	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726014833	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
329726014834	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726014835	dimerization interface [polypeptide binding]; other site
329726014836	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726014837	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726014838	metal binding site [ion binding]; metal-binding site
329726014839	active site
329726014840	I-site; other site
329726014841	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726014842	GAF domain; Region: GAF_3; pfam13492
329726014843	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726014844	GAF domain; Region: GAF; pfam01590
329726014845	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726014846	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726014847	metal binding site [ion binding]; metal-binding site
329726014848	active site
329726014849	I-site; other site
329726014850	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
329726014851	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
329726014852	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
329726014853	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
329726014854	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
329726014855	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
329726014856	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
329726014857	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
329726014858	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
329726014859	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726014860	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726014861	Uncharacterized conserved protein [Function unknown]; Region: COG0397
329726014862	hypothetical protein; Validated; Region: PRK00029
329726014863	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
329726014864	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
329726014865	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
329726014866	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726014867	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726014868	catalytic loop [active]
329726014869	iron binding site [ion binding]; other site
329726014870	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726014871	PAS fold; Region: PAS_3; pfam08447
329726014872	putative active site [active]
329726014873	heme pocket [chemical binding]; other site
329726014874	CheB methylesterase; Region: CheB_methylest; pfam01339
329726014875	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
329726014876	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
329726014877	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
329726014878	PAS domain; Region: PAS_10; pfam13596
329726014879	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726014880	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726014881	putative active site [active]
329726014882	heme pocket [chemical binding]; other site
329726014883	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726014884	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726014885	putative active site [active]
329726014886	heme pocket [chemical binding]; other site
329726014887	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
329726014888	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726014889	putative active site [active]
329726014890	heme pocket [chemical binding]; other site
329726014891	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726014892	dimer interface [polypeptide binding]; other site
329726014893	phosphorylation site [posttranslational modification]
329726014894	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726014895	ATP binding site [chemical binding]; other site
329726014896	Mg2+ binding site [ion binding]; other site
329726014897	G-X-G motif; other site
329726014898	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
329726014899	GAF domain; Region: GAF; pfam01590
329726014900	Phytochrome region; Region: PHY; pfam00360
329726014901	HWE histidine kinase; Region: HWE_HK; pfam07536
329726014902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
329726014903	active site
329726014904	phosphorylation site [posttranslational modification]
329726014905	intermolecular recognition site; other site
329726014906	dimerization interface [polypeptide binding]; other site
329726014907	Response regulator receiver domain; Region: Response_reg; pfam00072
329726014908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726014909	active site
329726014910	phosphorylation site [posttranslational modification]
329726014911	intermolecular recognition site; other site
329726014912	dimerization interface [polypeptide binding]; other site
329726014913	Response regulator receiver domain; Region: Response_reg; pfam00072
329726014914	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726014915	active site
329726014916	phosphorylation site [posttranslational modification]
329726014917	intermolecular recognition site; other site
329726014918	dimerization interface [polypeptide binding]; other site
329726014919	PAS domain S-box; Region: sensory_box; TIGR00229
329726014920	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726014921	putative active site [active]
329726014922	heme pocket [chemical binding]; other site
329726014923	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726014924	PAS domain; Region: PAS_9; pfam13426
329726014925	putative active site [active]
329726014926	heme pocket [chemical binding]; other site
329726014927	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726014928	PAS fold; Region: PAS_3; pfam08447
329726014929	putative active site [active]
329726014930	heme pocket [chemical binding]; other site
329726014931	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
329726014932	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726014933	dimer interface [polypeptide binding]; other site
329726014934	phosphorylation site [posttranslational modification]
329726014935	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726014936	ATP binding site [chemical binding]; other site
329726014937	Mg2+ binding site [ion binding]; other site
329726014938	G-X-G motif; other site
329726014939	MarR family; Region: MarR_2; cl17246
329726014940	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
329726014941	EamA-like transporter family; Region: EamA; pfam00892
329726014942	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
329726014943	EamA-like transporter family; Region: EamA; pfam00892
329726014944	Predicted membrane protein [Function unknown]; Region: COG1950
329726014945	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
329726014946	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
329726014947	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
329726014948	putative dimer interface [polypeptide binding]; other site
329726014949	N-terminal domain interface [polypeptide binding]; other site
329726014950	putative substrate binding pocket (H-site) [chemical binding]; other site
329726014951	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
329726014952	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
329726014953	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
329726014954	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
329726014955	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
329726014956	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726014957	homodimer interface [polypeptide binding]; other site
329726014958	catalytic residue [active]
329726014959	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
329726014960	IHF dimer interface [polypeptide binding]; other site
329726014961	IHF - DNA interface [nucleotide binding]; other site
329726014962	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
329726014963	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949
329726014964	Phage protein D [General function prediction only]; Region: COG3500
329726014965	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
329726014966	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
329726014967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
329726014968	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
329726014969	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
329726014970	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014971	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726014972	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014973	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014974	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726014975	polyribonucleotide nucleotidyltransferase; Region: polynuc_phos; TIGR03591
329726014976	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
329726014977	oligomer interface [polypeptide binding]; other site
329726014978	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
329726014979	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
329726014980	RNase E interface [polypeptide binding]; other site
329726014981	trimer interface [polypeptide binding]; other site
329726014982	active site
329726014983	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
329726014984	putative nucleic acid binding region [nucleotide binding]; other site
329726014985	G-X-X-G motif; other site
329726014986	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
329726014987	RNA binding site [nucleotide binding]; other site
329726014988	domain interface; other site
329726014989	SNF2 Helicase protein; Region: DUF3670; pfam12419
329726014990	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
329726014991	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726014992	ATP binding site [chemical binding]; other site
329726014993	putative Mg++ binding site [ion binding]; other site
329726014994	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726014995	nucleotide binding region [chemical binding]; other site
329726014996	ATP-binding site [chemical binding]; other site
329726014997	CHRD domain; Region: CHRD; pfam07452
329726014998	CHRD domain; Region: CHRD; pfam07452
329726014999	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015000	dimerization interface [polypeptide binding]; other site
329726015001	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726015002	dimer interface [polypeptide binding]; other site
329726015003	phosphorylation site [posttranslational modification]
329726015004	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726015005	ATP binding site [chemical binding]; other site
329726015006	Mg2+ binding site [ion binding]; other site
329726015007	G-X-G motif; other site
329726015008	Homeodomain-like domain; Region: HTH_23; pfam13384
329726015009	Winged helix-turn helix; Region: HTH_29; pfam13551
329726015010	Winged helix-turn helix; Region: HTH_33; pfam13592
329726015011	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726015012	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726015013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015014	active site
329726015015	phosphorylation site [posttranslational modification]
329726015016	intermolecular recognition site; other site
329726015017	heat shock protein 90; Provisional; Region: PRK05218
329726015018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726015019	ATP binding site [chemical binding]; other site
329726015020	Mg2+ binding site [ion binding]; other site
329726015021	G-X-G motif; other site
329726015022	2TM domain; Region: 2TM; pfam13239
329726015023	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
329726015024	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
329726015025	Double zinc ribbon; Region: DZR; pfam12773
329726015026	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726015027	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726015028	active site
329726015029	ATP binding site [chemical binding]; other site
329726015030	substrate binding site [chemical binding]; other site
329726015031	activation loop (A-loop); other site
329726015032	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015033	binding surface
329726015034	TPR motif; other site
329726015035	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726015036	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015037	binding surface
329726015038	TPR motif; other site
329726015039	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015040	binding surface
329726015041	TPR motif; other site
329726015042	H+ Antiporter protein; Region: 2A0121; TIGR00900
329726015043	GTP-binding protein Der; Reviewed; Region: PRK00093
329726015044	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
329726015045	G1 box; other site
329726015046	GTP/Mg2+ binding site [chemical binding]; other site
329726015047	Switch I region; other site
329726015048	G2 box; other site
329726015049	Switch II region; other site
329726015050	G3 box; other site
329726015051	G4 box; other site
329726015052	G5 box; other site
329726015053	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
329726015054	G1 box; other site
329726015055	GTP/Mg2+ binding site [chemical binding]; other site
329726015056	Switch I region; other site
329726015057	G2 box; other site
329726015058	G3 box; other site
329726015059	Switch II region; other site
329726015060	G4 box; other site
329726015061	G5 box; other site
329726015062	CpeS-like protein; Region: CpeS; pfam09367
329726015063	S-formylglutathione hydrolase; Region: PLN02442
329726015064	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
329726015065	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
329726015066	active site
329726015067	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
329726015068	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
329726015069	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
329726015070	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
329726015071	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
329726015072	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
329726015073	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726015074	non-specific DNA binding site [nucleotide binding]; other site
329726015075	salt bridge; other site
329726015076	sequence-specific DNA binding site [nucleotide binding]; other site
329726015077	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
329726015078	Predicted transcriptional regulators [Transcription]; Region: COG1733
329726015079	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
329726015080	glycine dehydrogenase; Provisional; Region: PRK05367
329726015081	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
329726015082	tetramer interface [polypeptide binding]; other site
329726015083	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726015084	catalytic residue [active]
329726015085	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
329726015086	tetramer interface [polypeptide binding]; other site
329726015087	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726015088	catalytic residue [active]
329726015089	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
329726015090	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726015091	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
329726015092	Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909
329726015093	active site
329726015094	Zn binding site [ion binding]; other site
329726015095	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726015096	dimerization interface [polypeptide binding]; other site
329726015097	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726015098	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726015099	metal binding site [ion binding]; metal-binding site
329726015100	active site
329726015101	I-site; other site
329726015102	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
329726015103	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
329726015104	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
329726015105	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
329726015106	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
329726015107	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
329726015108	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
329726015109	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
329726015110	AAA ATPase domain; Region: AAA_16; pfam13191
329726015111	NACHT domain; Region: NACHT; pfam05729
329726015112	TPR repeat; Region: TPR_11; pfam13414
329726015113	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015114	binding surface
329726015115	TPR motif; other site
329726015116	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726015117	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726015118	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015119	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726015120	TPR motif; other site
329726015121	binding surface
329726015122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
329726015123	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726015124	haemagglutination activity domain; Region: Haemagg_act; pfam05860
329726015125	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726015126	CHAT domain; Region: CHAT; cl17868
329726015127	CHASE2 domain; Region: CHASE2; pfam05226
329726015128	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
329726015129	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
329726015130	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015131	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726015132	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726015133	PAS fold; Region: PAS_3; pfam08447
329726015134	putative active site [active]
329726015135	heme pocket [chemical binding]; other site
329726015136	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015137	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726015138	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726015139	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726015140	dimer interface [polypeptide binding]; other site
329726015141	phosphorylation site [posttranslational modification]
329726015142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726015143	ATP binding site [chemical binding]; other site
329726015144	Mg2+ binding site [ion binding]; other site
329726015145	G-X-G motif; other site
329726015146	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726015147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015148	active site
329726015149	phosphorylation site [posttranslational modification]
329726015150	intermolecular recognition site; other site
329726015151	dimerization interface [polypeptide binding]; other site
329726015152	Response regulator receiver domain; Region: Response_reg; pfam00072
329726015153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015154	active site
329726015155	phosphorylation site [posttranslational modification]
329726015156	intermolecular recognition site; other site
329726015157	dimerization interface [polypeptide binding]; other site
329726015158	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726015159	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726015160	dimer interface [polypeptide binding]; other site
329726015161	phosphorylation site [posttranslational modification]
329726015162	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726015163	ATP binding site [chemical binding]; other site
329726015164	Mg2+ binding site [ion binding]; other site
329726015165	G-X-G motif; other site
329726015166	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726015167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015168	active site
329726015169	phosphorylation site [posttranslational modification]
329726015170	intermolecular recognition site; other site
329726015171	dimerization interface [polypeptide binding]; other site
329726015172	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726015173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015174	active site
329726015175	phosphorylation site [posttranslational modification]
329726015176	intermolecular recognition site; other site
329726015177	dimerization interface [polypeptide binding]; other site
329726015178	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
329726015179	putative binding surface; other site
329726015180	active site
329726015181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015182	active site
329726015183	phosphorylation site [posttranslational modification]
329726015184	intermolecular recognition site; other site
329726015185	PAS domain S-box; Region: sensory_box; TIGR00229
329726015186	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726015187	putative active site [active]
329726015188	heme pocket [chemical binding]; other site
329726015189	GAF domain; Region: GAF_3; pfam13492
329726015190	GAF domain; Region: GAF_2; pfam13185
329726015191	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
329726015192	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
329726015193	V4R domain; Region: V4R; cl15268
329726015194	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726015195	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
329726015196	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726015197	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726015198	S-layer homology domain; Region: SLH; pfam00395
329726015199	S-layer homology domain; Region: SLH; pfam00395
329726015200	S-layer homology domain; Region: SLH; pfam00395
329726015201	SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal...; Region: SCP_PR-1_like; cd05381
329726015202	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
329726015203	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
329726015204	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
329726015205	Walker A/P-loop; other site
329726015206	ATP binding site [chemical binding]; other site
329726015207	Q-loop/lid; other site
329726015208	ABC transporter signature motif; other site
329726015209	Walker B; other site
329726015210	D-loop; other site
329726015211	H-loop/switch region; other site
329726015212	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
329726015213	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
329726015214	Walker A/P-loop; other site
329726015215	ATP binding site [chemical binding]; other site
329726015216	Q-loop/lid; other site
329726015217	ABC transporter signature motif; other site
329726015218	Walker B; other site
329726015219	D-loop; other site
329726015220	H-loop/switch region; other site
329726015221	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
329726015222	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
329726015223	TM-ABC transporter signature motif; other site
329726015224	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
329726015225	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
329726015226	TM-ABC transporter signature motif; other site
329726015227	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
329726015228	Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331
329726015229	ligand binding site [chemical binding]; other site
329726015230	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
329726015231	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
329726015232	multimer interface [polypeptide binding]; other site
329726015233	active site
329726015234	catalytic triad [active]
329726015235	dimer interface [polypeptide binding]; other site
329726015236	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
329726015237	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
329726015238	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
329726015239	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
329726015240	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726015241	Ligand Binding Site [chemical binding]; other site
329726015242	FOG: CBS domain [General function prediction only]; Region: COG0517
329726015243	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
329726015244	FOG: CBS domain [General function prediction only]; Region: COG0517
329726015245	FOG: CBS domain [General function prediction only]; Region: COG0517
329726015246	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
329726015247	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015248	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726015249	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015250	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726015251	PAS fold; Region: PAS_4; pfam08448
329726015252	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
329726015253	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015254	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726015255	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015256	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726015257	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726015258	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726015259	dimer interface [polypeptide binding]; other site
329726015260	phosphorylation site [posttranslational modification]
329726015261	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726015262	ATP binding site [chemical binding]; other site
329726015263	Mg2+ binding site [ion binding]; other site
329726015264	G-X-G motif; other site
329726015265	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726015266	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015267	active site
329726015268	phosphorylation site [posttranslational modification]
329726015269	intermolecular recognition site; other site
329726015270	dimerization interface [polypeptide binding]; other site
329726015271	Predicted transcriptional regulators [Transcription]; Region: COG1695
329726015272	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
329726015273	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
329726015274	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
329726015275	interchain domain interface [polypeptide binding]; other site
329726015276	heme bL binding site [chemical binding]; other site
329726015277	intrachain domain interface; other site
329726015278	heme bH binding site [chemical binding]; other site
329726015279	Qo binding site; other site
329726015280	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
329726015281	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
329726015282	flavodoxin FldA; Validated; Region: PRK09267
329726015283	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726015284	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
329726015285	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726015286	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
329726015287	putative switch regulator; other site
329726015288	non-specific DNA interactions [nucleotide binding]; other site
329726015289	DNA binding site [nucleotide binding]
329726015290	sequence specific DNA binding site [nucleotide binding]; other site
329726015291	putative cAMP binding site [chemical binding]; other site
329726015292	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
329726015293	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
329726015294	catalytic triad [active]
329726015295	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
329726015296	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
329726015297	hypothetical protein; Provisional; Region: PRK07236
329726015298	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
329726015299	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726015300	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726015301	S-adenosylmethionine binding site [chemical binding]; other site
329726015302	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
329726015303	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
329726015304	active site
329726015305	dimer interface [polypeptide binding]; other site
329726015306	catalytic residue [active]
329726015307	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
329726015308	Ca2+ binding site [ion binding]; other site
329726015309	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
329726015310	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
329726015311	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726015312	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726015313	structural tetrad; other site
329726015314	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726015315	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726015316	structural tetrad; other site
329726015317	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
329726015318	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
329726015319	Uncharacterized conserved protein [Function unknown]; Region: COG5464
329726015320	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
329726015321	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
329726015322	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726015323	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726015324	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
329726015325	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
329726015326	substrate binding pocket [chemical binding]; other site
329726015327	aspartate-rich region 2; other site
329726015328	substrate-Mg2+ binding site; other site
329726015329	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726015330	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726015331	sulfotransferase; Region: PLN02164
329726015332	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
329726015333	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
329726015334	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
329726015335	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
329726015336	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
329726015337	Switch I; other site
329726015338	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
329726015339	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
329726015340	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
329726015341	Transposase; Region: DEDD_Tnp_IS110; pfam01548
329726015342	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
329726015343	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
329726015344	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
329726015345	Walker A/P-loop; other site
329726015346	ATP binding site [chemical binding]; other site
329726015347	Q-loop/lid; other site
329726015348	ABC transporter signature motif; other site
329726015349	Walker B; other site
329726015350	D-loop; other site
329726015351	H-loop/switch region; other site
329726015352	DNA polymerase III subunit delta'; Validated; Region: PRK07399
329726015353	DNA polymerase III subunit delta'; Validated; Region: PRK08485
329726015354	thymidylate kinase; Validated; Region: tmk; PRK00698
329726015355	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
329726015356	TMP-binding site; other site
329726015357	ATP-binding site [chemical binding]; other site
329726015358	PGAP1-like protein; Region: PGAP1; pfam07819
329726015359	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
329726015360	D1 interface; other site
329726015361	chlorophyll binding site; other site
329726015362	pheophytin binding site; other site
329726015363	beta carotene binding site; other site
329726015364	cytochrome b559 beta interface; other site
329726015365	quinone binding site; other site
329726015366	cytochrome b559 alpha interface; other site
329726015367	protein J interface; other site
329726015368	protein H interface; other site
329726015369	protein X interface; other site
329726015370	core light harvesting protein interface; other site
329726015371	protein L interface; other site
329726015372	CP43 interface; other site
329726015373	protein T interface; other site
329726015374	Fe binding site [ion binding]; other site
329726015375	protein M interface; other site
329726015376	Mn-stabilizing polypeptide interface; other site
329726015377	bromide binding site; other site
329726015378	cytochrome c-550 interface; other site
329726015379	sucrose synthase; Region: sucr_synth; TIGR02470
329726015380	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
329726015381	putative ADP-binding pocket [chemical binding]; other site
329726015382	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
329726015383	Ycf46; Provisional; Region: ycf46; CHL00195
329726015384	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726015385	Walker A motif; other site
329726015386	ATP binding site [chemical binding]; other site
329726015387	Walker B motif; other site
329726015388	arginine finger; other site
329726015389	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
329726015390	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726015391	PAS domain; Region: PAS_9; pfam13426
329726015392	putative active site [active]
329726015393	heme pocket [chemical binding]; other site
329726015394	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726015395	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726015396	metal binding site [ion binding]; metal-binding site
329726015397	active site
329726015398	I-site; other site
329726015399	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
329726015400	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
329726015401	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
329726015402	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
329726015403	histidine decarboxylase; Provisional; Region: PRK02769
329726015404	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
329726015405	catalytic residue [active]
329726015406	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726015407	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726015408	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015409	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726015410	TPR motif; other site
329726015411	binding surface
329726015412	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015413	binding surface
329726015414	TPR motif; other site
329726015415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015416	binding surface
329726015417	TPR motif; other site
329726015418	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726015419	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726015420	dimer interface [polypeptide binding]; other site
329726015421	phosphorylation site [posttranslational modification]
329726015422	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726015423	ATP binding site [chemical binding]; other site
329726015424	Mg2+ binding site [ion binding]; other site
329726015425	G-X-G motif; other site
329726015426	Response regulator receiver domain; Region: Response_reg; pfam00072
329726015427	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015428	active site
329726015429	phosphorylation site [posttranslational modification]
329726015430	intermolecular recognition site; other site
329726015431	dimerization interface [polypeptide binding]; other site
329726015432	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015433	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726015434	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726015435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726015436	dimer interface [polypeptide binding]; other site
329726015437	phosphorylation site [posttranslational modification]
329726015438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726015439	ATP binding site [chemical binding]; other site
329726015440	Mg2+ binding site [ion binding]; other site
329726015441	G-X-G motif; other site
329726015442	Response regulator receiver domain; Region: Response_reg; pfam00072
329726015443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015444	active site
329726015445	phosphorylation site [posttranslational modification]
329726015446	intermolecular recognition site; other site
329726015447	dimerization interface [polypeptide binding]; other site
329726015448	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
329726015449	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726015450	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726015451	structural tetrad; other site
329726015452	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726015453	structural tetrad; other site
329726015454	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726015455	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
329726015456	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
329726015457	Transposase domain (DUF772); Region: DUF772; pfam05598
329726015458	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726015459	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015460	TPR motif; other site
329726015461	TPR repeat; Region: TPR_11; pfam13414
329726015462	binding surface
329726015463	TPR repeat; Region: TPR_11; pfam13414
329726015464	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
329726015465	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
329726015466	putative NAD(P) binding site [chemical binding]; other site
329726015467	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
329726015468	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726015469	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
329726015470	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
329726015471	AAA ATPase domain; Region: AAA_16; pfam13191
329726015472	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015473	TPR motif; other site
329726015474	binding surface
329726015475	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726015476	DNA binding residues [nucleotide binding]
329726015477	dimerization interface [polypeptide binding]; other site
329726015478	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
329726015479	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726015480	DNA binding residues [nucleotide binding]
329726015481	dimerization interface [polypeptide binding]; other site
329726015482	Predicted membrane protein [Function unknown]; Region: COG4270
329726015483	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726015484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726015485	S-adenosylmethionine binding site [chemical binding]; other site
329726015486	topology modulation protein; Reviewed; Region: PRK08118
329726015487	AAA domain; Region: AAA_17; pfam13207
329726015488	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
329726015489	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726015490	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726015491	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726015492	WHG domain; Region: WHG; pfam13305
329726015493	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726015494	NADH(P)-binding; Region: NAD_binding_10; pfam13460
329726015495	NAD(P) binding site [chemical binding]; other site
329726015496	active site
329726015497	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
329726015498	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726015499	NAD(P) binding site [chemical binding]; other site
329726015500	active site
329726015501	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726015502	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726015503	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
329726015504	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
329726015505	putative NAD(P) binding site [chemical binding]; other site
329726015506	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
329726015507	phosphate binding site [ion binding]; other site
329726015508	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
329726015509	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726015510	motif II; other site
329726015511	Domain of unknown function (DUF4269); Region: DUF4269; pfam14091
329726015512	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
329726015513	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726015514	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726015515	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
329726015516	NADH(P)-binding; Region: NAD_binding_10; pfam13460
329726015517	NAD binding site [chemical binding]; other site
329726015518	substrate binding site [chemical binding]; other site
329726015519	putative active site [active]
329726015520	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
329726015521	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
329726015522	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
329726015523	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726015524	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
329726015525	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726015526	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726015527	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
329726015528	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726015529	NmrA-like family; Region: NmrA; pfam05368
329726015530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726015531	NAD(P) binding site [chemical binding]; other site
329726015532	active site
329726015533	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726015534	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726015535	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726015536	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
329726015537	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726015538	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726015539	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726015540	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726015541	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
329726015542	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726015543	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726015544	active site
329726015545	DNA binding site [nucleotide binding]
329726015546	Int/Topo IB signature motif; other site
329726015547	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
329726015548	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726015549	YcfA-like protein; Region: YcfA; pfam07927
329726015550	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
329726015551	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149
329726015552	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
329726015553	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
329726015554	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
329726015555	dimerization interface [polypeptide binding]; other site
329726015556	DPS ferroxidase diiron center [ion binding]; other site
329726015557	ion pore; other site
329726015558	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726015559	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726015560	Transcriptional regulator [Transcription]; Region: LysR; COG0583
329726015561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726015562	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
329726015563	putative substrate binding pocket [chemical binding]; other site
329726015564	putative dimerization interface [polypeptide binding]; other site
329726015565	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
329726015566	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
329726015567	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726015568	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
329726015569	Protein export membrane protein; Region: SecD_SecF; cl14618
329726015570	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
329726015571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726015572	NAD(P) binding site [chemical binding]; other site
329726015573	active site
329726015574	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
329726015575	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
329726015576	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
329726015577	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726015578	NAD(P) binding site [chemical binding]; other site
329726015579	active site
329726015580	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726015581	NmrA-like family; Region: NmrA; pfam05368
329726015582	NAD(P) binding site [chemical binding]; other site
329726015583	active site
329726015584	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
329726015585	NmrA-like family; Region: NmrA; pfam05368
329726015586	NADP binding site [chemical binding]; other site
329726015587	active site
329726015588	regulatory binding site [polypeptide binding]; other site
329726015589	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
329726015590	classical (c) SDRs; Region: SDR_c; cd05233
329726015591	NAD(P) binding site [chemical binding]; other site
329726015592	active site
329726015593	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
329726015594	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
329726015595	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
329726015596	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
329726015597	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
329726015598	GUN4-like; Region: GUN4; pfam05419
329726015599	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
329726015600	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726015601	active site
329726015602	metal binding site [ion binding]; metal-binding site
329726015603	transposase; Validated; Region: PRK08181
329726015604	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726015605	Walker A motif; other site
329726015606	ATP binding site [chemical binding]; other site
329726015607	Integrase core domain; Region: rve; pfam00665
329726015608	universal archaeal protein Kae1; Region: arch_KAE1; TIGR03722
329726015609	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region; Region: zf-PARP; pfam00645
329726015610	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726015611	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726015612	Homeodomain-like domain; Region: HTH_23; pfam13384
329726015613	Winged helix-turn helix; Region: HTH_29; pfam13551
329726015614	Homeodomain-like domain; Region: HTH_32; pfam13565
329726015615	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
329726015616	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726015617	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
329726015618	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726015619	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726015620	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726015621	DNA binding residues [nucleotide binding]
329726015622	Transposase domain (DUF772); Region: DUF772; pfam05598
329726015623	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726015624	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
329726015625	IHF dimer interface [polypeptide binding]; other site
329726015626	IHF - DNA interface [nucleotide binding]; other site
329726015627	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726015628	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
329726015629	Domain of unknown function (DUF955); Region: DUF955; pfam06114
329726015630	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
329726015631	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
329726015632	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
329726015633	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726015634	non-specific DNA binding site [nucleotide binding]; other site
329726015635	salt bridge; other site
329726015636	sequence-specific DNA binding site [nucleotide binding]; other site
329726015637	Double zinc ribbon; Region: DZR; pfam12773
329726015638	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
329726015639	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726015640	active site
329726015641	DNA binding site [nucleotide binding]
329726015642	Int/Topo IB signature motif; other site
329726015643	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
329726015644	Cation efflux family; Region: Cation_efflux; cl00316
329726015645	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
329726015646	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
329726015647	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726015648	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726015649	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
329726015650	DNA binding site [nucleotide binding]
329726015651	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726015652	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726015653	metal binding site [ion binding]; metal-binding site
329726015654	active site
329726015655	I-site; other site
329726015656	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
329726015657	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
329726015658	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
329726015659	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726015660	DNA binding site [nucleotide binding]
329726015661	active site
329726015662	Int/Topo IB signature motif; other site
329726015663	SnoaL-like domain; Region: SnoaL_2; pfam12680
329726015664	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726015665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015666	active site
329726015667	phosphorylation site [posttranslational modification]
329726015668	intermolecular recognition site; other site
329726015669	dimerization interface [polypeptide binding]; other site
329726015670	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726015671	DNA binding site [nucleotide binding]
329726015672	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726015673	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726015674	dimerization interface [polypeptide binding]; other site
329726015675	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726015676	dimer interface [polypeptide binding]; other site
329726015677	phosphorylation site [posttranslational modification]
329726015678	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726015679	ATP binding site [chemical binding]; other site
329726015680	Mg2+ binding site [ion binding]; other site
329726015681	G-X-G motif; other site
329726015682	Predicted membrane protein [Function unknown]; Region: COG2259
329726015683	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
329726015684	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
329726015685	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
329726015686	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
329726015687	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726015688	NAD(P) binding site [chemical binding]; other site
329726015689	active site
329726015690	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
329726015691	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726015692	active site
329726015693	Int/Topo IB signature motif; other site
329726015694	DNA binding site [nucleotide binding]
329726015695	Ion channel; Region: Ion_trans_2; pfam07885
329726015696	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
329726015697	TrkA-N domain; Region: TrkA_N; pfam02254
329726015698	TrkA-C domain; Region: TrkA_C; pfam02080
329726015699	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726015700	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726015701	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
329726015702	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
329726015703	HAMP domain; Region: HAMP; pfam00672
329726015704	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726015705	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726015706	AAA ATPase domain; Region: AAA_16; pfam13191
329726015707	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726015708	WD domain, G-beta repeat; Region: WD40; pfam00400
329726015709	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726015710	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726015711	structural tetrad; other site
329726015712	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726015713	structural tetrad; other site
329726015714	WD40 repeats; Region: WD40; smart00320
329726015715	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
329726015716	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726015717	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
329726015718	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726015719	structural tetrad; other site
329726015720	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726015721	structural tetrad; other site
329726015722	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726015723	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
329726015724	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
329726015725	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
329726015726	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
329726015727	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
329726015728	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
329726015729	putative active site [active]
329726015730	putative NTP binding site [chemical binding]; other site
329726015731	putative nucleic acid binding site [nucleotide binding]; other site
329726015732	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
329726015733	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
329726015734	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
329726015735	active site
329726015736	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
329726015737	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726015738	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
329726015739	active site
329726015740	metal binding site [ion binding]; metal-binding site
329726015741	Cupin; Region: Cupin_6; pfam12852
329726015742	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726015743	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726015744	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726015745	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
329726015746	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
329726015747	putative NAD(P) binding site [chemical binding]; other site
329726015748	Integrase core domain; Region: rve; pfam00665
329726015749	transposase; Validated; Region: PRK08181
329726015750	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726015751	Walker A motif; other site
329726015752	ATP binding site [chemical binding]; other site
329726015753	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
329726015754	Right handed beta helix region; Region: Beta_helix; pfam13229
329726015755	Transposase, Mutator family; Region: Transposase_mut; pfam00872
329726015756	MULE transposase domain; Region: MULE; pfam10551
329726015757	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
329726015758	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
329726015759	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
329726015760	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726015761	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
329726015762	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
329726015763	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
329726015764	active site
329726015765	catalytic tetrad [active]
329726015766	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726015767	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726015768	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726015769	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726015770	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726015771	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726015772	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726015773	Homeodomain-like domain; Region: HTH_23; pfam13384
329726015774	Winged helix-turn helix; Region: HTH_29; pfam13551
329726015775	Winged helix-turn helix; Region: HTH_33; pfam13592
329726015776	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726015777	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726015778	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726015779	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726015780	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726015781	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726015782	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
329726015783	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
329726015784	active site
329726015785	substrate binding site [chemical binding]; other site
329726015786	catalytic site [active]
329726015787	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726015788	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726015789	phosphopeptide binding site; other site
329726015790	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
329726015791	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
329726015792	Transposase [DNA replication, recombination, and repair]; Region: COG5421
329726015793	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
329726015794	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
329726015795	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726015796	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
329726015797	Transposase IS200 like; Region: Y1_Tnp; pfam01797
329726015798	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726015799	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726015800	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015801	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726015802	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015803	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726015804	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015805	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726015806	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015807	GAF domain; Region: GAF; cl17456
329726015808	GAF domain; Region: GAF; cl17456
329726015809	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015810	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015811	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015812	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726015813	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
329726015814	Histidine kinase; Region: HisKA_3; pfam07730
329726015815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726015816	ATP binding site [chemical binding]; other site
329726015817	Mg2+ binding site [ion binding]; other site
329726015818	G-X-G motif; other site
329726015819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726015820	S-adenosylmethionine binding site [chemical binding]; other site
329726015821	Helix-turn-helix domain; Region: HTH_28; pfam13518
329726015822	Winged helix-turn helix; Region: HTH_29; pfam13551
329726015823	Homeodomain-like domain; Region: HTH_32; pfam13565
329726015824	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
329726015825	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726015826	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726015827	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
329726015828	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726015829	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
329726015830	active site
329726015831	ATP binding site [chemical binding]; other site
329726015832	substrate binding site [chemical binding]; other site
329726015833	activation loop (A-loop); other site
329726015834	GUN4-like; Region: GUN4; pfam05419
329726015835	Uncharacterized conserved protein [Function unknown]; Region: COG5361
329726015836	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
329726015837	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
329726015838	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
329726015839	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
329726015840	putative DNA binding site [nucleotide binding]; other site
329726015841	dimerization interface [polypeptide binding]; other site
329726015842	putative Zn2+ binding site [ion binding]; other site
329726015843	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015844	GAF domain; Region: GAF; pfam01590
329726015845	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726015846	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726015847	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726015848	dimer interface [polypeptide binding]; other site
329726015849	phosphorylation site [posttranslational modification]
329726015850	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726015851	ATP binding site [chemical binding]; other site
329726015852	Mg2+ binding site [ion binding]; other site
329726015853	G-X-G motif; other site
329726015854	Response regulator receiver domain; Region: Response_reg; pfam00072
329726015855	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015856	active site
329726015857	phosphorylation site [posttranslational modification]
329726015858	intermolecular recognition site; other site
329726015859	dimerization interface [polypeptide binding]; other site
329726015860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015861	active site
329726015862	phosphorylation site [posttranslational modification]
329726015863	intermolecular recognition site; other site
329726015864	dimerization interface [polypeptide binding]; other site
329726015865	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
329726015866	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726015867	non-specific DNA binding site [nucleotide binding]; other site
329726015868	salt bridge; other site
329726015869	sequence-specific DNA binding site [nucleotide binding]; other site
329726015870	Clp amino terminal domain; Region: Clp_N; pfam02861
329726015871	GAF domain; Region: GAF; cl17456
329726015872	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726015873	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726015874	DNA binding residues [nucleotide binding]
329726015875	dimerization interface [polypeptide binding]; other site
329726015876	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726015877	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726015878	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726015879	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
329726015880	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
329726015881	conserved cys residue [active]
329726015882	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015883	TPR repeat; Region: TPR_11; pfam13414
329726015884	binding surface
329726015885	TPR motif; other site
329726015886	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726015887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015888	active site
329726015889	phosphorylation site [posttranslational modification]
329726015890	intermolecular recognition site; other site
329726015891	dimerization interface [polypeptide binding]; other site
329726015892	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726015893	DNA binding residues [nucleotide binding]
329726015894	dimerization interface [polypeptide binding]; other site
329726015895	Thioredoxin; Region: Thioredoxin_4; cl17273
329726015896	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726015897	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726015898	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726015899	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726015900	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726015901	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726015902	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
329726015903	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
329726015904	putative active site [active]
329726015905	catalytic residue [active]
329726015906	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
329726015907	SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798
329726015908	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
329726015909	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
329726015910	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
329726015911	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
329726015912	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
329726015913	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
329726015914	AMP binding site [chemical binding]; other site
329726015915	metal binding site [ion binding]; metal-binding site
329726015916	active site
329726015917	Electron transfer DM13; Region: DM13; cl02735
329726015918	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
329726015919	Low molecular weight phosphatase family; Region: LMWPc; cl00105
329726015920	active site
329726015921	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
329726015922	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
329726015923	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
329726015924	catalytic residue [active]
329726015925	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
329726015926	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
329726015927	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726015928	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726015929	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726015930	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
329726015931	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726015932	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726015933	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726015934	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726015935	TPR repeat; Region: TPR_11; pfam13414
329726015936	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015937	binding surface
329726015938	TPR motif; other site
329726015939	TPR repeat; Region: TPR_11; pfam13414
329726015940	TPR repeat; Region: TPR_11; pfam13414
329726015941	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015942	binding surface
329726015943	TPR motif; other site
329726015944	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726015945	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015946	binding surface
329726015947	TPR motif; other site
329726015948	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015949	binding surface
329726015950	TPR motif; other site
329726015951	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726015952	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015953	TPR motif; other site
329726015954	binding surface
329726015955	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015956	binding surface
329726015957	TPR motif; other site
329726015958	TPR repeat; Region: TPR_11; pfam13414
329726015959	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015960	binding surface
329726015961	TPR motif; other site
329726015962	TPR repeat; Region: TPR_11; pfam13414
329726015963	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726015964	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726015965	TPR repeat; Region: TPR_11; pfam13414
329726015966	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015967	binding surface
329726015968	TPR motif; other site
329726015969	TPR repeat; Region: TPR_11; pfam13414
329726015970	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015971	binding surface
329726015972	TPR motif; other site
329726015973	TPR repeat; Region: TPR_11; pfam13414
329726015974	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726015975	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015976	binding surface
329726015977	TPR motif; other site
329726015978	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015979	binding surface
329726015980	TPR motif; other site
329726015981	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015982	binding surface
329726015983	TPR motif; other site
329726015984	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726015985	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015986	binding surface
329726015987	TPR motif; other site
329726015988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726015989	binding surface
329726015990	TPR motif; other site
329726015991	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726015992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726015993	active site
329726015994	phosphorylation site [posttranslational modification]
329726015995	intermolecular recognition site; other site
329726015996	dimerization interface [polypeptide binding]; other site
329726015997	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726015998	DNA binding site [nucleotide binding]
329726015999	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726016000	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726016001	dimerization interface [polypeptide binding]; other site
329726016002	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726016003	dimer interface [polypeptide binding]; other site
329726016004	phosphorylation site [posttranslational modification]
329726016005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726016006	ATP binding site [chemical binding]; other site
329726016007	Mg2+ binding site [ion binding]; other site
329726016008	G-X-G motif; other site
329726016009	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726016010	Ligand Binding Site [chemical binding]; other site
329726016011	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
329726016012	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
329726016013	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
329726016014	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
329726016015	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726016016	motif II; other site
329726016017	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
329726016018	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726016019	Ligand Binding Site [chemical binding]; other site
329726016020	Circadian oscillating protein COP23; Region: COP23; pfam14218
329726016021	CHAT domain; Region: CHAT; cl17868
329726016022	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
329726016023	CHASE2 domain; Region: CHASE2; pfam05226
329726016024	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
329726016025	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
329726016026	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726016027	DNA binding residues [nucleotide binding]
329726016028	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
329726016029	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
329726016030	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
329726016031	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
329726016032	catalytic site [active]
329726016033	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
329726016034	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
329726016035	EamA-like transporter family; Region: EamA; pfam00892
329726016036	ATP-grasp domain; Region: ATP-grasp_4; cl17255
329726016037	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
329726016038	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
329726016039	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
329726016040	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
329726016041	Rab subfamily motif 1 (RabSF1); other site
329726016042	G1 box; other site
329726016043	GTP/Mg2+ binding site [chemical binding]; other site
329726016044	Rab subfamily motif 2 (RabSF2); other site
329726016045	Switch I region; other site
329726016046	G2 box; other site
329726016047	effector interaction site; other site
329726016048	GDI interaction site; other site
329726016049	Rab family motif 1 (RabF1); other site
329726016050	GEF interaction site [polypeptide binding]; other site
329726016051	Rab family motif 2 (RabF2); other site
329726016052	G3 box; other site
329726016053	Switch II region; other site
329726016054	Rab family motif 3 (RabF3); other site
329726016055	Rab family motif 4 (RabF4); other site
329726016056	Rab family motif 5 (RabF5); other site
329726016057	Rab subfamily motif 3 (RabSF3); other site
329726016058	G4 box; other site
329726016059	G5 box; other site
329726016060	Rab subfamily motif 4 (RabSF4); other site
329726016061	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
329726016062	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
329726016063	substrate binding site [chemical binding]; other site
329726016064	active site
329726016065	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726016066	metal binding site 2 [ion binding]; metal-binding site
329726016067	putative DNA binding helix; other site
329726016068	metal binding site 1 [ion binding]; metal-binding site
329726016069	dimer interface [polypeptide binding]; other site
329726016070	structural Zn2+ binding site [ion binding]; other site
329726016071	Domain of unknown function (DUF1817); Region: DUF1817; cl02292
329726016072	glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317
329726016073	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
329726016074	Response regulator receiver domain; Region: Response_reg; pfam00072
329726016075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726016076	active site
329726016077	phosphorylation site [posttranslational modification]
329726016078	intermolecular recognition site; other site
329726016079	dimerization interface [polypeptide binding]; other site
329726016080	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726016081	ATP binding site [chemical binding]; other site
329726016082	Mg2+ binding site [ion binding]; other site
329726016083	G-X-G motif; other site
329726016084	PAS domain; Region: PAS_9; pfam13426
329726016085	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726016086	putative active site [active]
329726016087	heme pocket [chemical binding]; other site
329726016088	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726016089	GAF domain; Region: GAF; cl17456
329726016090	PAS fold; Region: PAS_4; pfam08448
329726016091	GAF domain; Region: GAF; pfam01590
329726016092	PAS domain S-box; Region: sensory_box; TIGR00229
329726016093	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726016094	putative active site [active]
329726016095	heme pocket [chemical binding]; other site
329726016096	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726016097	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
329726016098	putative active site [active]
329726016099	heme pocket [chemical binding]; other site
329726016100	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726016101	dimer interface [polypeptide binding]; other site
329726016102	phosphorylation site [posttranslational modification]
329726016103	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726016104	ATP binding site [chemical binding]; other site
329726016105	Mg2+ binding site [ion binding]; other site
329726016106	G-X-G motif; other site
329726016107	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726016108	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726016109	active site
329726016110	phosphorylation site [posttranslational modification]
329726016111	intermolecular recognition site; other site
329726016112	dimerization interface [polypeptide binding]; other site
329726016113	Response regulator receiver domain; Region: Response_reg; pfam00072
329726016114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726016115	active site
329726016116	phosphorylation site [posttranslational modification]
329726016117	intermolecular recognition site; other site
329726016118	dimerization interface [polypeptide binding]; other site
329726016119	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726016120	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726016121	dimer interface [polypeptide binding]; other site
329726016122	phosphorylation site [posttranslational modification]
329726016123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726016124	ATP binding site [chemical binding]; other site
329726016125	Mg2+ binding site [ion binding]; other site
329726016126	G-X-G motif; other site
329726016127	Response regulator receiver domain; Region: Response_reg; pfam00072
329726016128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726016129	active site
329726016130	phosphorylation site [posttranslational modification]
329726016131	intermolecular recognition site; other site
329726016132	dimerization interface [polypeptide binding]; other site
329726016133	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
329726016134	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
329726016135	putative ligand binding site [chemical binding]; other site
329726016136	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
329726016137	Phosphate transporter family; Region: PHO4; pfam01384
329726016138	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
329726016139	classical (c) SDRs; Region: SDR_c; cd05233
329726016140	NAD(P) binding site [chemical binding]; other site
329726016141	active site
329726016142	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726016143	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726016144	active site
329726016145	ATP binding site [chemical binding]; other site
329726016146	substrate binding site [chemical binding]; other site
329726016147	activation loop (A-loop); other site
329726016148	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726016149	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726016150	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
329726016151	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
329726016152	active site
329726016153	dimer interface [polypeptide binding]; other site
329726016154	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
329726016155	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
329726016156	active site
329726016157	FMN binding site [chemical binding]; other site
329726016158	substrate binding site [chemical binding]; other site
329726016159	3Fe-4S cluster binding site [ion binding]; other site
329726016160	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
329726016161	domain interface; other site
329726016162	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726016163	non-specific DNA binding site [nucleotide binding]; other site
329726016164	salt bridge; other site
329726016165	sequence-specific DNA binding site [nucleotide binding]; other site
329726016166	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
329726016167	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
329726016168	Fasciclin domain; Region: Fasciclin; pfam02469
329726016169	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
329726016170	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
329726016171	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
329726016172	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
329726016173	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
329726016174	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726016175	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726016176	dimerization interface [polypeptide binding]; other site
329726016177	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726016178	dimer interface [polypeptide binding]; other site
329726016179	phosphorylation site [posttranslational modification]
329726016180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726016181	ATP binding site [chemical binding]; other site
329726016182	Mg2+ binding site [ion binding]; other site
329726016183	G-X-G motif; other site
329726016184	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
329726016185	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
329726016186	catalytic core [active]
329726016187	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
329726016188	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
329726016189	active site
329726016190	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
329726016191	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
329726016192	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
329726016193	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
329726016194	active site
329726016195	catalytic tetrad [active]
329726016196	Protein of unknown function DUF104; Region: DUF104; pfam01954
329726016197	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
329726016198	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
329726016199	active site
329726016200	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
329726016201	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
329726016202	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726016203	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726016204	Walker A/P-loop; other site
329726016205	ATP binding site [chemical binding]; other site
329726016206	Q-loop/lid; other site
329726016207	ABC transporter signature motif; other site
329726016208	Walker B; other site
329726016209	D-loop; other site
329726016210	H-loop/switch region; other site
329726016211	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726016212	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
329726016213	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
329726016214	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726016215	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726016216	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
329726016217	Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases; Region: POLO_box; cl02916
329726016218	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
329726016219	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
329726016220	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
329726016221	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726016222	Response regulator receiver domain; Region: Response_reg; pfam00072
329726016223	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726016224	active site
329726016225	phosphorylation site [posttranslational modification]
329726016226	intermolecular recognition site; other site
329726016227	dimerization interface [polypeptide binding]; other site
329726016228	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726016229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726016230	active site
329726016231	phosphorylation site [posttranslational modification]
329726016232	intermolecular recognition site; other site
329726016233	dimerization interface [polypeptide binding]; other site
329726016234	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726016235	DNA binding site [nucleotide binding]
329726016236	Acylphosphatase; Region: Acylphosphatase; pfam00708
329726016237	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
329726016238	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
329726016239	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
329726016240	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
329726016241	active site
329726016242	catalytic site [active]
329726016243	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
329726016244	Homeodomain-like domain; Region: HTH_23; pfam13384
329726016245	Winged helix-turn helix; Region: HTH_29; pfam13551
329726016246	Homeodomain-like domain; Region: HTH_32; pfam13565
329726016247	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726016248	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726016249	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
329726016250	structural tetrad; other site
329726016251	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726016252	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
329726016253	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726016254	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726016255	ligand binding site [chemical binding]; other site
329726016256	flexible hinge region; other site
329726016257	phage tail protein domain; Region: tail_TIGR02242
329726016258	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
329726016259	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
329726016260	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
329726016261	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
329726016262	homotrimer interaction site [polypeptide binding]; other site
329726016263	active site
329726016264	FOG: CBS domain [General function prediction only]; Region: COG0517
329726016265	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636
329726016266	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
329726016267	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
329726016268	C-terminal domain interface [polypeptide binding]; other site
329726016269	GSH binding site (G-site) [chemical binding]; other site
329726016270	dimer interface [polypeptide binding]; other site
329726016271	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
329726016272	N-terminal domain interface [polypeptide binding]; other site
329726016273	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
329726016274	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
329726016275	hypothetical protein; Provisional; Region: PRK10039
329726016276	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
329726016277	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
329726016278	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
329726016279	transposase; Validated; Region: PRK08181
329726016280	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726016281	Walker A motif; other site
329726016282	ATP binding site [chemical binding]; other site
329726016283	Integrase core domain; Region: rve; pfam00665
329726016284	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
329726016285	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
329726016286	cofactor binding site; other site
329726016287	DNA binding site [nucleotide binding]
329726016288	substrate interaction site [chemical binding]; other site
329726016289	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
329726016290	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
329726016291	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726016292	ATP binding site [chemical binding]; other site
329726016293	Mg2+ binding site [ion binding]; other site
329726016294	G-X-G motif; other site
329726016295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726016296	active site
329726016297	phosphorylation site [posttranslational modification]
329726016298	intermolecular recognition site; other site
329726016299	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
329726016300	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
329726016301	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726016302	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726016303	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
329726016304	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
329726016305	AAA-like domain; Region: AAA_10; pfam12846
329726016306	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
329726016307	Walker A motif; other site
329726016308	ATP binding site [chemical binding]; other site
329726016309	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726016310	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
329726016311	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726016312	non-specific DNA binding site [nucleotide binding]; other site
329726016313	salt bridge; other site
329726016314	sequence-specific DNA binding site [nucleotide binding]; other site
329726016315	ParB-like nuclease domain; Region: ParB; smart00470
329726016316	NB-ARC domain; Region: NB-ARC; pfam00931
329726016317	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
329726016318	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726016319	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726016320	binding surface
329726016321	TPR motif; other site
329726016322	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726016323	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726016324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726016325	S-adenosylmethionine binding site [chemical binding]; other site
329726016326	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054
329726016327	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
329726016328	Mechanosensitive ion channel; Region: MS_channel; pfam00924
329726016329	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
329726016330	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
329726016331	generic binding surface I; other site
329726016332	generic binding surface II; other site
329726016333	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
329726016334	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
329726016335	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
329726016336	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726016337	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726016338	Uncharacterized conserved protein [Function unknown]; Region: COG2128
329726016339	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
329726016340	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
329726016341	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
329726016342	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
329726016343	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
329726016344	dsRNA binding site [nucleotide binding]; other site
329726016345	Protein of unknown function (DUF552); Region: DUF552; pfam04472
329726016346	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
329726016347	RibD C-terminal domain; Region: RibD_C; cl17279
329726016348	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
329726016349	iron-sulfur cluster [ion binding]; other site
329726016350	[2Fe-2S] cluster binding site [ion binding]; other site
329726016351	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
329726016352	hydrophobic ligand binding site; other site
329726016353	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
329726016354	active site
329726016355	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
329726016356	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
329726016357	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726016358	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726016359	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
329726016360	protein binding site [polypeptide binding]; other site
329726016361	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
329726016362	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
329726016363	SLBB domain; Region: SLBB; pfam10531
329726016364	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
329726016365	SLBB domain; Region: SLBB; pfam10531
329726016366	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726016367	CpXC protein; Region: CpXC; pfam14353
329726016368	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
329726016369	Transglycosylase; Region: Transgly; pfam00912
329726016370	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
329726016371	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
329726016372	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
329726016373	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
329726016374	DNA binding site [nucleotide binding]
329726016375	AAA domain; Region: AAA_30; pfam13604
329726016376	Family description; Region: UvrD_C_2; pfam13538
329726016377	recombinase A; Provisional; Region: recA; PRK09354
329726016378	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
329726016379	hexamer interface [polypeptide binding]; other site
329726016380	Walker A motif; other site
329726016381	ATP binding site [chemical binding]; other site
329726016382	Walker B motif; other site
329726016383	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726016384	Coenzyme A binding pocket [chemical binding]; other site
329726016385	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
329726016386	RNB domain; Region: RNB; pfam00773
329726016387	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
329726016388	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
329726016389	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
329726016390	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
329726016391	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
329726016392	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
329726016393	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
329726016394	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
329726016395	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
329726016396	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
329726016397	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
329726016398	phosphopeptide binding site; other site
329726016399	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726016400	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726016401	short chain dehydrogenase; Provisional; Region: PRK06197
329726016402	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
329726016403	putative NAD(P) binding site [chemical binding]; other site
329726016404	active site
329726016405	short chain dehydrogenase; Validated; Region: PRK06182
329726016406	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
329726016407	NADP binding site [chemical binding]; other site
329726016408	active site
329726016409	steroid binding site; other site
329726016410	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
329726016411	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
329726016412	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
329726016413	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
329726016414	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
329726016415	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
329726016416	chorismate binding enzyme; Region: Chorismate_bind; cl10555
329726016417	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
329726016418	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
329726016419	FMN binding site [chemical binding]; other site
329726016420	active site
329726016421	substrate binding site [chemical binding]; other site
329726016422	catalytic residue [active]
329726016423	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
329726016424	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
329726016425	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
329726016426	YcfA-like protein; Region: YcfA; pfam07927
329726016427	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
329726016428	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
329726016429	putative active site [active]
329726016430	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726016431	active site
329726016432	DNA binding site [nucleotide binding]
329726016433	Int/Topo IB signature motif; other site
329726016434	Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053
329726016435	diiron binding motif [ion binding]; other site
329726016436	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
329726016437	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726016438	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726016439	ligand binding site [chemical binding]; other site
329726016440	flexible hinge region; other site
329726016441	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
329726016442	putative switch regulator; other site
329726016443	non-specific DNA interactions [nucleotide binding]; other site
329726016444	DNA binding site [nucleotide binding]
329726016445	sequence specific DNA binding site [nucleotide binding]; other site
329726016446	putative cAMP binding site [chemical binding]; other site
329726016447	Cation efflux family; Region: Cation_efflux; cl00316
329726016448	FeoA domain; Region: FeoA; pfam04023
329726016449	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
329726016450	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
329726016451	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
329726016452	G1 box; other site
329726016453	GTP/Mg2+ binding site [chemical binding]; other site
329726016454	Switch I region; other site
329726016455	G2 box; other site
329726016456	G3 box; other site
329726016457	Switch II region; other site
329726016458	G4 box; other site
329726016459	G5 box; other site
329726016460	Nucleoside recognition; Region: Gate; pfam07670
329726016461	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
329726016462	Nucleoside recognition; Region: Gate; pfam07670
329726016463	FeoC like transcriptional regulator; Region: FeoC; pfam09012
329726016464	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
329726016465	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
329726016466	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
329726016467	dimerization interface [polypeptide binding]; other site
329726016468	DPS ferroxidase diiron center [ion binding]; other site
329726016469	ion pore; other site
329726016470	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
329726016471	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
329726016472	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726016473	Walker A/P-loop; other site
329726016474	ATP binding site [chemical binding]; other site
329726016475	Q-loop/lid; other site
329726016476	ABC transporter signature motif; other site
329726016477	Walker B; other site
329726016478	D-loop; other site
329726016479	H-loop/switch region; other site
329726016480	H+ Antiporter protein; Region: 2A0121; TIGR00900
329726016481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726016482	putative substrate translocation pore; other site
329726016483	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
329726016484	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
329726016485	siderophore binding site; other site
329726016486	AMIN domain; Region: AMIN; pfam11741
329726016487	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
329726016488	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
329726016489	N-terminal plug; other site
329726016490	ligand-binding site [chemical binding]; other site
329726016491	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
329726016492	putative dimer interface [polypeptide binding]; other site
329726016493	putative [2Fe-2S] cluster binding site [ion binding]; other site
329726016494	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726016495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726016496	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
329726016497	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
329726016498	Walker A/P-loop; other site
329726016499	ATP binding site [chemical binding]; other site
329726016500	Q-loop/lid; other site
329726016501	ABC transporter signature motif; other site
329726016502	Walker B; other site
329726016503	D-loop; other site
329726016504	H-loop/switch region; other site
329726016505	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
329726016506	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
329726016507	ABC-ATPase subunit  interface; other site
329726016508	dimer interface [polypeptide binding]; other site
329726016509	putative PBP binding regions; other site
329726016510	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
329726016511	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
329726016512	ABC-ATPase subunit  interface; other site
329726016513	dimer interface [polypeptide binding]; other site
329726016514	putative PBP binding regions; other site
329726016515	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
329726016516	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
329726016517	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
329726016518	H+ Antiporter protein; Region: 2A0121; TIGR00900
329726016519	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726016520	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726016521	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726016522	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
329726016523	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
329726016524	N-terminal plug; other site
329726016525	ligand-binding site [chemical binding]; other site
329726016526	muropeptide transporter; Validated; Region: ampG; cl17669
329726016527	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
329726016528	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726016529	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726016530	Walker A/P-loop; other site
329726016531	ATP binding site [chemical binding]; other site
329726016532	Q-loop/lid; other site
329726016533	ABC transporter signature motif; other site
329726016534	Walker B; other site
329726016535	D-loop; other site
329726016536	H-loop/switch region; other site
329726016537	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
329726016538	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726016539	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726016540	Walker A/P-loop; other site
329726016541	ATP binding site [chemical binding]; other site
329726016542	Q-loop/lid; other site
329726016543	ABC transporter signature motif; other site
329726016544	Walker B; other site
329726016545	D-loop; other site
329726016546	H-loop/switch region; other site
329726016547	Phosphotransferase enzyme family; Region: APH; pfam01636
329726016548	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
329726016549	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726016550	Coenzyme A binding pocket [chemical binding]; other site
329726016551	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726016552	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726016553	Coenzyme A binding pocket [chemical binding]; other site
329726016554	Predicted acetyltransferase [General function prediction only]; Region: COG5628
329726016555	H+ Antiporter protein; Region: 2A0121; TIGR00900
329726016556	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
329726016557	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
329726016558	siderophore binding site; other site
329726016559	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
329726016560	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
329726016561	siderophore binding site; other site
329726016562	AMIN domain; Region: AMIN; pfam11741
329726016563	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
329726016564	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
329726016565	N-terminal plug; other site
329726016566	ligand-binding site [chemical binding]; other site
329726016567	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
329726016568	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
329726016569	intersubunit interface [polypeptide binding]; other site
329726016570	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726016571	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726016572	DDE superfamily endonuclease; Region: DDE_4; pfam13359
329726016573	putative transposase OrfB; Reviewed; Region: PHA02517
329726016574	HTH-like domain; Region: HTH_21; pfam13276
329726016575	Integrase core domain; Region: rve; pfam00665
329726016576	Integrase core domain; Region: rve_3; pfam13683
329726016577	Transposase; Region: HTH_Tnp_1; pfam01527
329726016578	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
329726016579	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
329726016580	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
329726016581	intersubunit interface [polypeptide binding]; other site
329726016582	AMIN domain; Region: AMIN; pfam11741
329726016583	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
329726016584	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
329726016585	N-terminal plug; other site
329726016586	ligand-binding site [chemical binding]; other site
329726016587	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726016588	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726016589	Predicted membrane protein [Function unknown]; Region: COG2119
329726016590	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
329726016591	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
329726016592	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
329726016593	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
329726016594	Leucine carboxyl methyltransferase; Region: LCM; cl01306
329726016595	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
329726016596	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
329726016597	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726016598	Transposase domain (DUF772); Region: DUF772; pfam05598
329726016599	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
329726016600	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726016601	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
329726016602	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726016603	Walker A motif; other site
329726016604	Walker A/P-loop; other site
329726016605	ATP binding site [chemical binding]; other site
329726016606	Walker B motif; other site
329726016607	arginine finger; other site
329726016608	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
329726016609	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
329726016610	Transposase IS200 like; Region: Y1_Tnp; cl00848
329726016611	DDE superfamily endonuclease; Region: DDE_5; cl17874
329726016612	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726016613	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726016614	hypothetical protein; Validated; Region: PRK06840
329726016615	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
329726016616	active site
329726016617	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
329726016618	Condensation domain; Region: Condensation; pfam00668
329726016619	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
329726016620	Nonribosomal peptide synthase; Region: NRPS; pfam08415
329726016621	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
329726016622	acyl-activating enzyme (AAE) consensus motif; other site
329726016623	AMP binding site [chemical binding]; other site
329726016624	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
329726016625	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
329726016626	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
329726016627	active site
329726016628	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
329726016629	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
329726016630	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
329726016631	putative NADP binding site [chemical binding]; other site
329726016632	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
329726016633	active site
329726016634	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
329726016635	Condensation domain; Region: Condensation; pfam00668
329726016636	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
329726016637	Nonribosomal peptide synthase; Region: NRPS; pfam08415
329726016638	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
329726016639	acyl-activating enzyme (AAE) consensus motif; other site
329726016640	AMP binding site [chemical binding]; other site
329726016641	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
329726016642	putative FMN binding site [chemical binding]; other site
329726016643	NADPH bind site [chemical binding]; other site
329726016644	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
329726016645	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
329726016646	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
329726016647	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
329726016648	active site
329726016649	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
329726016650	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
329726016651	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
329726016652	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
329726016653	putative NADP binding site [chemical binding]; other site
329726016654	active site
329726016655	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
329726016656	Condensation domain; Region: Condensation; pfam00668
329726016657	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
329726016658	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
329726016659	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
329726016660	acyl-activating enzyme (AAE) consensus motif; other site
329726016661	AMP binding site [chemical binding]; other site
329726016662	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
329726016663	Condensation domain; Region: Condensation; pfam00668
329726016664	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
329726016665	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
329726016666	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
329726016667	acyl-activating enzyme (AAE) consensus motif; other site
329726016668	AMP binding site [chemical binding]; other site
329726016669	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
329726016670	Condensation domain; Region: Condensation; pfam00668
329726016671	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
329726016672	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
329726016673	Condensation domain; Region: Condensation; pfam00668
329726016674	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
329726016675	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
329726016676	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
329726016677	inhibitor-cofactor binding pocket; inhibition site
329726016678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726016679	catalytic residue [active]
329726016680	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
329726016681	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
329726016682	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
329726016683	acyl-activating enzyme (AAE) consensus motif; other site
329726016684	AMP binding site [chemical binding]; other site
329726016685	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
329726016686	Condensation domain; Region: Condensation; pfam00668
329726016687	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
329726016688	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
329726016689	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
329726016690	acyl-activating enzyme (AAE) consensus motif; other site
329726016691	AMP binding site [chemical binding]; other site
329726016692	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
329726016693	Condensation domain; Region: Condensation; pfam00668
329726016694	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
329726016695	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
329726016696	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
329726016697	acyl-activating enzyme (AAE) consensus motif; other site
329726016698	AMP binding site [chemical binding]; other site
329726016699	Condensation domain; Region: Condensation; pfam00668
329726016700	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
329726016701	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
329726016702	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
329726016703	acyl-activating enzyme (AAE) consensus motif; other site
329726016704	AMP binding site [chemical binding]; other site
329726016705	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
329726016706	thioester reductase domain; Region: Thioester-redct; TIGR01746
329726016707	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
329726016708	putative NAD(P) binding site [chemical binding]; other site
329726016709	active site
329726016710	putative substrate binding site [chemical binding]; other site
329726016711	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
329726016712	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726016713	S-adenosylmethionine binding site [chemical binding]; other site
329726016714	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
329726016715	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726016716	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
329726016717	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
329726016718	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
329726016719	inhibitor-cofactor binding pocket; inhibition site
329726016720	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726016721	catalytic residue [active]
329726016722	Phosphopantetheine attachment site; Region: PP-binding; cl09936
329726016723	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
329726016724	Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959
329726016725	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
329726016726	dimer interface [polypeptide binding]; other site
329726016727	acyl-activating enzyme (AAE) consensus motif; other site
329726016728	putative active site [active]
329726016729	putative AMP binding site [chemical binding]; other site
329726016730	putative CoA binding site [chemical binding]; other site
329726016731	chemical substrate binding site [chemical binding]; other site
329726016732	salicylate synthase; Region: salicyl_syn; TIGR03494
329726016733	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
329726016734	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
329726016735	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
329726016736	putative dimer interface [polypeptide binding]; other site
329726016737	putative [2Fe-2S] cluster binding site [ion binding]; other site
329726016738	H+ Antiporter protein; Region: 2A0121; TIGR00900
329726016739	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726016740	putative substrate translocation pore; other site
329726016741	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
329726016742	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726016743	P-loop; other site
329726016744	Magnesium ion binding site [ion binding]; other site
329726016745	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726016746	Magnesium ion binding site [ion binding]; other site
329726016747	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
329726016748	ParB-like nuclease domain; Region: ParBc; pfam02195
329726016749	Staphylococcal nuclease homologue; Region: SNase; pfam00565
329726016750	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
329726016751	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
329726016752	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
329726016753	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
329726016754	putative active site [active]
329726016755	putative NTP binding site [chemical binding]; other site
329726016756	putative nucleic acid binding site [nucleotide binding]; other site
329726016757	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
329726016758	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
329726016759	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
329726016760	active site
329726016761	transposase; Validated; Region: PRK08181
329726016762	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726016763	Walker A motif; other site
329726016764	ATP binding site [chemical binding]; other site
329726016765	Integrase core domain; Region: rve; pfam00665
329726016766	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726016767	active site
329726016768	DNA binding site [nucleotide binding]
329726016769	Int/Topo IB signature motif; other site
329726016770	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726016771	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
329726016772	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
329726016773	Coenzyme A binding pocket [chemical binding]; other site
329726016774	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726016775	metal binding site 2 [ion binding]; metal-binding site
329726016776	putative DNA binding helix; other site
329726016777	metal binding site 1 [ion binding]; metal-binding site
329726016778	dimer interface [polypeptide binding]; other site
329726016779	structural Zn2+ binding site [ion binding]; other site
329726016780	Predicted membrane protein [Function unknown]; Region: COG2119
329726016781	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
329726016782	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
329726016783	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
329726016784	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
329726016785	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
329726016786	muropeptide transporter; Validated; Region: ampG; cl17669
329726016787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
329726016788	AMIN domain; Region: AMIN; pfam11741
329726016789	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
329726016790	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
329726016791	N-terminal plug; other site
329726016792	ligand-binding site [chemical binding]; other site
329726016793	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726016794	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726016795	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
329726016796	active site clefts [active]
329726016797	zinc binding site [ion binding]; other site
329726016798	dimer interface [polypeptide binding]; other site
329726016799	Uncharacterized conserved protein [Function unknown]; Region: COG5464
329726016800	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
329726016801	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
329726016802	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
329726016803	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
329726016804	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726016805	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726016806	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726016807	ligand binding site [chemical binding]; other site
329726016808	flexible hinge region; other site
329726016809	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
329726016810	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
329726016811	putative active site [active]
329726016812	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
329726016813	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726016814	Walker A/P-loop; other site
329726016815	ATP binding site [chemical binding]; other site
329726016816	Q-loop/lid; other site
329726016817	ABC transporter signature motif; other site
329726016818	Walker B; other site
329726016819	D-loop; other site
329726016820	H-loop/switch region; other site
329726016821	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
329726016822	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
329726016823	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
329726016824	RTX toxin acyltransferase family; Region: HlyC; pfam02794
329726016825	RTX toxin acyltransferase family; Region: HlyC; pfam02794
329726016826	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726016827	haemagglutination activity domain; Region: Haemagg_act; pfam05860
329726016828	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
329726016829	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726016830	binding surface
329726016831	TPR motif; other site
329726016832	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726016833	TPR motif; other site
329726016834	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726016835	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
329726016836	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
329726016837	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
329726016838	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
329726016839	putative active site [active]
329726016840	putative substrate binding site [chemical binding]; other site
329726016841	putative cosubstrate binding site; other site
329726016842	catalytic site [active]
329726016843	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
329726016844	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
329726016845	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
329726016846	substrate binding site [chemical binding]; other site
329726016847	oxyanion hole (OAH) forming residues; other site
329726016848	trimer interface [polypeptide binding]; other site
329726016849	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726016850	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726016851	structural tetrad; other site
329726016852	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726016853	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726016854	structural tetrad; other site
329726016855	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726016856	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726016857	Coenzyme A binding pocket [chemical binding]; other site
329726016858	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
329726016859	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
329726016860	dimer interface [polypeptide binding]; other site
329726016861	decamer (pentamer of dimers) interface [polypeptide binding]; other site
329726016862	catalytic triad [active]
329726016863	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
329726016864	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
329726016865	active site
329726016866	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
329726016867	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
329726016868	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
329726016869	dimer interface [polypeptide binding]; other site
329726016870	pyridoxal 5'-phosphate binding site [chemical binding]; other site
329726016871	catalytic residue [active]
329726016872	Berberine and berberine like; Region: BBE; pfam08031
329726016873	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
329726016874	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
329726016875	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
329726016876	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726016877	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726016878	ParB-like nuclease domain; Region: ParBc; pfam02195
329726016879	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
329726016880	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
329726016881	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726016882	P-loop; other site
329726016883	Magnesium ion binding site [ion binding]; other site
329726016884	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726016885	Magnesium ion binding site [ion binding]; other site
329726016886	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726016887	TPR motif; other site
329726016888	TPR repeat; Region: TPR_11; pfam13414
329726016889	binding surface
329726016890	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726016891	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726016892	ligand binding site [chemical binding]; other site
329726016893	flexible hinge region; other site
329726016894	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
329726016895	putative switch regulator; other site
329726016896	non-specific DNA interactions [nucleotide binding]; other site
329726016897	DNA binding site [nucleotide binding]
329726016898	sequence specific DNA binding site [nucleotide binding]; other site
329726016899	putative cAMP binding site [chemical binding]; other site
329726016900	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
329726016901	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
329726016902	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
329726016903	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
329726016904	cofactor binding site; other site
329726016905	DNA binding site [nucleotide binding]
329726016906	substrate interaction site [chemical binding]; other site
329726016907	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
329726016908	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
329726016909	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
329726016910	dimer interface [polypeptide binding]; other site
329726016911	ssDNA binding site [nucleotide binding]; other site
329726016912	tetramer (dimer of dimers) interface [polypeptide binding]; other site
329726016913	Vps52 / Sac2 family; Region: Vps52; pfam04129
329726016914	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
329726016915	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
329726016916	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726016917	non-specific DNA binding site [nucleotide binding]; other site
329726016918	salt bridge; other site
329726016919	sequence-specific DNA binding site [nucleotide binding]; other site
329726016920	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726016921	non-specific DNA binding site [nucleotide binding]; other site
329726016922	salt bridge; other site
329726016923	sequence-specific DNA binding site [nucleotide binding]; other site
329726016924	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
329726016925	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
329726016926	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726016927	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
329726016928	IHF - DNA interface [nucleotide binding]; other site
329726016929	IHF dimer interface [polypeptide binding]; other site
329726016930	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
329726016931	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726016932	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726016933	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726016934	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726016935	DNA binding residues [nucleotide binding]
329726016936	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
329726016937	hypothetical protein; Provisional; Region: PRK08445
329726016938	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
329726016939	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726016940	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
329726016941	anti sigma factor interaction site; other site
329726016942	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
329726016943	regulatory phosphorylation site [posttranslational modification]; other site
329726016944	Response regulator receiver domain; Region: Response_reg; pfam00072
329726016945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726016946	active site
329726016947	phosphorylation site [posttranslational modification]
329726016948	intermolecular recognition site; other site
329726016949	dimerization interface [polypeptide binding]; other site
329726016950	Response regulator receiver domain; Region: Response_reg; pfam00072
329726016951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726016952	active site
329726016953	phosphorylation site [posttranslational modification]
329726016954	intermolecular recognition site; other site
329726016955	dimerization interface [polypeptide binding]; other site
329726016956	Cache domain; Region: Cache_1; pfam02743
329726016957	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
329726016958	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726016959	dimerization interface [polypeptide binding]; other site
329726016960	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726016961	dimer interface [polypeptide binding]; other site
329726016962	phosphorylation site [posttranslational modification]
329726016963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726016964	ATP binding site [chemical binding]; other site
329726016965	Mg2+ binding site [ion binding]; other site
329726016966	G-X-G motif; other site
329726016967	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726016968	active site
329726016969	phosphorylation site [posttranslational modification]
329726016970	intermolecular recognition site; other site
329726016971	dimerization interface [polypeptide binding]; other site
329726016972	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
329726016973	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
329726016974	Transposase, Mutator family; Region: Transposase_mut; pfam00872
329726016975	MULE transposase domain; Region: MULE; pfam10551
329726016976	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
329726016977	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
329726016978	nucleotide binding site [chemical binding]; other site
329726016979	TrwC relaxase; Region: TrwC; pfam08751
329726016980	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
329726016981	AAA domain; Region: AAA_30; pfam13604
329726016982	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
329726016983	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
329726016984	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
329726016985	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
329726016986	dimerization interface [polypeptide binding]; other site
329726016987	putative DNA binding site [nucleotide binding]; other site
329726016988	putative Zn2+ binding site [ion binding]; other site
329726016989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726016990	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726016991	transposase; Validated; Region: PRK08181
329726016992	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726016993	Walker A motif; other site
329726016994	ATP binding site [chemical binding]; other site
329726016995	Integrase core domain; Region: rve; pfam00665
329726016996	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726016997	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
329726016998	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
329726016999	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726017000	Walker A motif; other site
329726017001	ATP binding site [chemical binding]; other site
329726017002	Walker B motif; other site
329726017003	arginine finger; other site
329726017004	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726017005	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726017006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726017007	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
329726017008	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726017009	Integrase core domain; Region: rve; pfam00665
329726017010	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
329726017011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726017012	Walker A motif; other site
329726017013	ATP binding site [chemical binding]; other site
329726017014	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726017015	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726017016	TPR repeat; Region: TPR_11; pfam13414
329726017017	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726017018	binding surface
329726017019	TPR motif; other site
329726017020	TPR repeat; Region: TPR_11; pfam13414
329726017021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
329726017022	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
329726017023	PAS fold; Region: PAS; pfam00989
329726017024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726017025	putative active site [active]
329726017026	heme pocket [chemical binding]; other site
329726017027	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726017028	PAS fold; Region: PAS_3; pfam08447
329726017029	putative active site [active]
329726017030	heme pocket [chemical binding]; other site
329726017031	PAS domain; Region: PAS_9; pfam13426
329726017032	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
329726017033	putative active site [active]
329726017034	heme pocket [chemical binding]; other site
329726017035	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
329726017036	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
329726017037	putative amphipathic alpha helix; other site
329726017038	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
329726017039	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
329726017040	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
329726017041	ParA-like protein; Provisional; Region: PHA02518
329726017042	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726017043	P-loop; other site
329726017044	Magnesium ion binding site [ion binding]; other site
329726017045	ParB-like nuclease domain; Region: ParBc; pfam02195
329726017046	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
329726017047	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
329726017048	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726017049	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
329726017050	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
329726017051	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
329726017052	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726017053	Coenzyme A binding pocket [chemical binding]; other site
329726017054	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726017055	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726017056	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
329726017057	zinc binding site [ion binding]; other site
329726017058	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
329726017059	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726017060	NAD(P) binding site [chemical binding]; other site
329726017061	active site
329726017062	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
329726017063	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726017064	Coenzyme A binding pocket [chemical binding]; other site
329726017065	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
329726017066	homotrimer interaction site [polypeptide binding]; other site
329726017067	putative active site [active]
329726017068	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
329726017069	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726017070	Walker A/P-loop; other site
329726017071	ATP binding site [chemical binding]; other site
329726017072	Q-loop/lid; other site
329726017073	ABC transporter signature motif; other site
329726017074	Walker B; other site
329726017075	D-loop; other site
329726017076	H-loop/switch region; other site
329726017077	Homeodomain-like domain; Region: HTH_23; pfam13384
329726017078	Winged helix-turn helix; Region: HTH_29; pfam13551
329726017079	Winged helix-turn helix; Region: HTH_33; pfam13592
329726017080	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726017081	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726017082	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726017083	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
329726017084	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
329726017085	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
329726017086	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726017087	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
329726017088	catalytic site [active]
329726017089	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726017090	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
329726017091	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
329726017092	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
329726017093	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
329726017094	active site
329726017095	Predicted transcriptional regulators [Transcription]; Region: COG1733
329726017096	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
329726017097	putative Zn2+ binding site [ion binding]; other site
329726017098	putative DNA binding site [nucleotide binding]; other site
329726017099	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726017100	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726017101	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726017102	Coenzyme A binding pocket [chemical binding]; other site
329726017103	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726017104	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
329726017105	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726017106	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
329726017107	dimer interface [polypeptide binding]; other site
329726017108	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
329726017109	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726017110	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
329726017111	Protein of unknown function, DUF488; Region: DUF488; cl01246
329726017112	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
329726017113	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
329726017114	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
329726017115	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726017116	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
329726017117	IHF - DNA interface [nucleotide binding]; other site
329726017118	IHF dimer interface [polypeptide binding]; other site
329726017119	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
329726017120	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726017121	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726017122	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726017123	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
329726017124	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
329726017125	anti sigma factor interaction site; other site
329726017126	regulatory phosphorylation site [posttranslational modification]; other site
329726017127	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
329726017128	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
329726017129	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
329726017130	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
329726017131	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017132	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017133	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017134	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017135	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017136	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017137	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
329726017138	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726017139	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
329726017140	active site
329726017141	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726017142	Coenzyme A binding pocket [chemical binding]; other site
329726017143	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726017144	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726017145	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726017146	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
329726017147	Cytochrome P450; Region: p450; cl12078
329726017148	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
329726017149	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
329726017150	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
329726017151	Domain of unknown function (DUF336); Region: DUF336; pfam03928
329726017152	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
329726017153	formamidase; Provisional; Region: amiF; PRK13287
329726017154	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
329726017155	multimer interface [polypeptide binding]; other site
329726017156	active site
329726017157	catalytic triad [active]
329726017158	dimer interface [polypeptide binding]; other site
329726017159	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017160	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
329726017161	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
329726017162	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
329726017163	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
329726017164	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
329726017165	ABC-ATPase subunit  interface; other site
329726017166	dimer interface [polypeptide binding]; other site
329726017167	putative PBP binding regions; other site
329726017168	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
329726017169	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
329726017170	active site
329726017171	metal binding site [ion binding]; metal-binding site
329726017172	hexamer interface [polypeptide binding]; other site
329726017173	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
329726017174	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
329726017175	putative ligand binding site [chemical binding]; other site
329726017176	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
329726017177	dimer interface [polypeptide binding]; other site
329726017178	[2Fe-2S] cluster binding site [ion binding]; other site
329726017179	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
329726017180	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
329726017181	N-terminal plug; other site
329726017182	ligand-binding site [chemical binding]; other site
329726017183	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726017184	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
329726017185	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
329726017186	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
329726017187	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
329726017188	putative C-terminal domain interface [polypeptide binding]; other site
329726017189	putative GSH binding site (G-site) [chemical binding]; other site
329726017190	putative dimer interface [polypeptide binding]; other site
329726017191	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
329726017192	putative N-terminal domain interface [polypeptide binding]; other site
329726017193	putative dimer interface [polypeptide binding]; other site
329726017194	putative substrate binding pocket (H-site) [chemical binding]; other site
329726017195	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
329726017196	GSH binding site [chemical binding]; other site
329726017197	catalytic residues [active]
329726017198	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
329726017199	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726017200	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726017201	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
329726017202	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726017203	metal binding site 2 [ion binding]; metal-binding site
329726017204	putative DNA binding helix; other site
329726017205	metal binding site 1 [ion binding]; metal-binding site
329726017206	dimer interface [polypeptide binding]; other site
329726017207	structural Zn2+ binding site [ion binding]; other site
329726017208	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
329726017209	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
329726017210	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726017211	metal binding site 2 [ion binding]; metal-binding site
329726017212	putative DNA binding helix; other site
329726017213	metal binding site 1 [ion binding]; metal-binding site
329726017214	dimer interface [polypeptide binding]; other site
329726017215	structural Zn2+ binding site [ion binding]; other site
329726017216	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726017217	metal binding site 2 [ion binding]; metal-binding site
329726017218	putative DNA binding helix; other site
329726017219	metal binding site 1 [ion binding]; metal-binding site
329726017220	dimer interface [polypeptide binding]; other site
329726017221	structural Zn2+ binding site [ion binding]; other site
329726017222	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
329726017223	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
329726017224	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
329726017225	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
329726017226	putative DNA binding helix; other site
329726017227	metal binding site 2 [ion binding]; metal-binding site
329726017228	metal binding site 1 [ion binding]; metal-binding site
329726017229	dimer interface [polypeptide binding]; other site
329726017230	structural Zn2+ binding site [ion binding]; other site
329726017231	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
329726017232	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
329726017233	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
329726017234	Walker A motif; other site
329726017235	ATP binding site [chemical binding]; other site
329726017236	Walker B motif; other site
329726017237	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726017238	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726017239	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
329726017240	putative DNA binding site [nucleotide binding]; other site
329726017241	dimerization interface [polypeptide binding]; other site
329726017242	putative Zn2+ binding site [ion binding]; other site
329726017243	acyl-CoA synthetase; Validated; Region: PRK05850
329726017244	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
329726017245	acyl-activating enzyme (AAE) consensus motif; other site
329726017246	active site
329726017247	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
329726017248	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
329726017249	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
329726017250	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
329726017251	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
329726017252	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
329726017253	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
329726017254	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
329726017255	active site
329726017256	HIGH motif; other site
329726017257	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
329726017258	KMSKS motif; other site
329726017259	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
329726017260	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
329726017261	active site
329726017262	dimer interface [polypeptide binding]; other site
329726017263	motif 1; other site
329726017264	motif 2; other site
329726017265	motif 3; other site
329726017266	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
329726017267	anticodon binding site; other site
329726017268	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726017269	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726017270	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
329726017271	homodecamer interface [polypeptide binding]; other site
329726017272	GTP cyclohydrolase I; Provisional; Region: PLN03044
329726017273	active site
329726017274	putative catalytic site residues [active]
329726017275	zinc binding site [ion binding]; other site
329726017276	GTP-CH-I/GFRP interaction surface; other site
329726017277	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
329726017278	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
329726017279	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726017280	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
329726017281	dihydroorotase; Reviewed; Region: PRK09236
329726017282	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
329726017283	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
329726017284	active site
329726017285	NACHT domain; Region: NACHT; pfam05729
329726017286	NTPase; Region: NTPase_1; cl17478
329726017287	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
329726017288	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726017289	active site
329726017290	Int/Topo IB signature motif; other site
329726017291	DNA binding site [nucleotide binding]
329726017292	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
329726017293	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
329726017294	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
329726017295	HicB family; Region: HicB; pfam05534
329726017296	AAA ATPase domain; Region: AAA_16; pfam13191
329726017297	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726017298	structural tetrad; other site
329726017299	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726017300	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726017301	structural tetrad; other site
329726017302	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726017303	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
329726017304	Tetratricopeptide repeat; Region: TPR_9; pfam13371
329726017305	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
329726017306	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
329726017307	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726017308	active site
329726017309	DNA binding site [nucleotide binding]
329726017310	Int/Topo IB signature motif; other site
329726017311	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017312	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017313	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017314	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017315	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017316	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017317	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
329726017318	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
329726017319	Catalytic site [active]
329726017320	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
329726017321	active site
329726017322	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
329726017323	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
329726017324	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
329726017325	Catalytic site; other site
329726017326	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
329726017327	Transposase, Mutator family; Region: Transposase_mut; pfam00872
329726017328	MULE transposase domain; Region: MULE; pfam10551
329726017329	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
329726017330	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726017331	Walker A motif; other site
329726017332	ATP binding site [chemical binding]; other site
329726017333	Walker B motif; other site
329726017334	arginine finger; other site
329726017335	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
329726017336	Integrase core domain; Region: rve; pfam00665
329726017337	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
329726017338	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
329726017339	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
329726017340	metal ion-dependent adhesion site (MIDAS); other site
329726017341	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726017342	haemagglutination activity domain; Region: Haemagg_act; pfam05860
329726017343	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726017344	Coenzyme A binding pocket [chemical binding]; other site
329726017345	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
329726017346	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
329726017347	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
329726017348	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726017349	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726017350	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726017351	Probable transposase; Region: OrfB_IS605; pfam01385
329726017352	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
329726017353	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
329726017354	RRXRR protein; Region: RRXRR; pfam14239
329726017355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
329726017356	Probable transposase; Region: OrfB_IS605; pfam01385
329726017357	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
329726017358	Mg binding site [ion binding]; other site
329726017359	nucleotide binding site [chemical binding]; other site
329726017360	putative protofilament interface [polypeptide binding]; other site
329726017361	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726017362	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726017363	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726017364	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726017365	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726017366	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726017367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726017368	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
329726017369	Walker A motif; other site
329726017370	ATP binding site [chemical binding]; other site
329726017371	Walker B motif; other site
329726017372	arginine finger; other site
329726017373	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
329726017374	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726017375	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726017376	TrwC relaxase; Region: TrwC; pfam08751
329726017377	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
329726017378	AAA domain; Region: AAA_30; pfam13604
329726017379	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
329726017380	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
329726017381	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
329726017382	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
329726017383	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726017384	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726017385	AAA-like domain; Region: AAA_10; pfam12846
329726017386	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
329726017387	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726017388	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
329726017389	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726017390	Walker A/P-loop; other site
329726017391	ATP binding site [chemical binding]; other site
329726017392	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
329726017393	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726017394	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726017395	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726017396	DNA binding residues [nucleotide binding]
329726017397	AAA ATPase domain; Region: AAA_16; pfam13191
329726017398	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726017399	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726017400	active site
329726017401	ATP binding site [chemical binding]; other site
329726017402	substrate binding site [chemical binding]; other site
329726017403	activation loop (A-loop); other site
329726017404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726017405	TPR motif; other site
329726017406	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726017407	binding surface
329726017408	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726017409	binding surface
329726017410	TPR motif; other site
329726017411	TPR repeat; Region: TPR_11; pfam13414
329726017412	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726017413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726017414	binding surface
329726017415	TPR motif; other site
329726017416	CHAT domain; Region: CHAT; cl17868
329726017417	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726017418	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
329726017419	Cytochrome P450; Region: p450; cl12078
329726017420	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
329726017421	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
329726017422	classical (c) SDRs; Region: SDR_c; cd05233
329726017423	NAD(P) binding site [chemical binding]; other site
329726017424	active site
329726017425	AAA ATPase domain; Region: AAA_16; pfam13191
329726017426	NACHT domain; Region: NACHT; pfam05729
329726017427	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726017428	structural tetrad; other site
329726017429	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726017430	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726017431	structural tetrad; other site
329726017432	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726017433	structural tetrad; other site
329726017434	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726017435	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
329726017436	Staphylococcal nuclease homologues; Region: SNc; smart00318
329726017437	Catalytic site; other site
329726017438	Staphylococcal nuclease homologue; Region: SNase; pfam00565
329726017439	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
329726017440	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
329726017441	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
329726017442	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
329726017443	Catalytic site [active]
329726017444	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
329726017445	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
329726017446	active site
329726017447	DNA binding site [nucleotide binding]
329726017448	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
329726017449	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017450	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017451	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017452	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017453	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017454	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017455	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017456	Ion channel; Region: Ion_trans_2; pfam07885
329726017457	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017458	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017459	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726017460	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017461	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017462	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017463	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017464	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017465	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017466	thiamine biosynthesis protein ThiF, family 2; Region: thiF_fam2; TIGR02354
329726017467	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726017468	NACHT domain; Region: NACHT; pfam05729
329726017469	Walker A motif; other site
329726017470	ATP binding site [chemical binding]; other site
329726017471	Walker B motif; other site
329726017472	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017473	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726017474	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726017475	structural tetrad; other site
329726017476	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726017477	structural tetrad; other site
329726017478	WD domain, G-beta repeat; Region: WD40; pfam00400
329726017479	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726017480	active site
329726017481	DNA binding site [nucleotide binding]
329726017482	Int/Topo IB signature motif; other site
329726017483	ParA-like protein; Provisional; Region: PHA02518
329726017484	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726017485	P-loop; other site
329726017486	Magnesium ion binding site [ion binding]; other site
329726017487	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
329726017488	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017489	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726017490	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017491	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017492	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017493	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017494	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726017495	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017496	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017497	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017498	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017499	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017500	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017501	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017502	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
329726017503	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726017504	non-specific DNA binding site [nucleotide binding]; other site
329726017505	salt bridge; other site
329726017506	sequence-specific DNA binding site [nucleotide binding]; other site
329726017507	Double zinc ribbon; Region: DZR; pfam12773
329726017508	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
329726017509	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726017510	active site
329726017511	DNA binding site [nucleotide binding]
329726017512	Int/Topo IB signature motif; other site
329726017513	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
329726017514	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
329726017515	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
329726017516	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
329726017517	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
329726017518	putative active site [active]
329726017519	putative NTP binding site [chemical binding]; other site
329726017520	putative nucleic acid binding site [nucleotide binding]; other site
329726017521	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
329726017522	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
329726017523	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
329726017524	active site
329726017525	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
329726017526	HicB family; Region: HicB; pfam05534
329726017527	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
329726017528	oligomeric interface; other site
329726017529	putative active site [active]
329726017530	homodimer interface [polypeptide binding]; other site
329726017531	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
329726017532	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726017533	Walker A/P-loop; other site
329726017534	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
329726017535	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
329726017536	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726017537	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
329726017538	active site
329726017539	DNA binding site [nucleotide binding]
329726017540	Int/Topo IB signature motif; other site
329726017541	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726017542	structural tetrad; other site
329726017543	PQQ-like domain; Region: PQQ_2; pfam13360
329726017544	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
329726017545	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
329726017546	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726017547	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726017548	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726017549	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
329726017550	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726017551	Ferritin-like; Region: Ferritin-like; pfam12902
329726017552	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
329726017553	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726017554	DNA binding site [nucleotide binding]
329726017555	active site
329726017556	Int/Topo IB signature motif; other site
329726017557	Staphylococcal nuclease homologues; Region: SNc; smart00318
329726017558	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
329726017559	Catalytic site; other site
329726017560	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726017561	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726017562	Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818
329726017563	putative heme binding site [chemical binding]; other site
329726017564	putative active site [active]
329726017565	putative substrate binding site [chemical binding]; other site
329726017566	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
329726017567	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
329726017568	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726017569	non-specific DNA binding site [nucleotide binding]; other site
329726017570	salt bridge; other site
329726017571	sequence-specific DNA binding site [nucleotide binding]; other site
329726017572	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
329726017573	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726017574	sequence-specific DNA binding site [nucleotide binding]; other site
329726017575	salt bridge; other site
329726017576	DDE domain; Region: DDE_Tnp_IS240; pfam13610
329726017577	transposase; Validated; Region: PRK08181
329726017578	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726017579	Walker A motif; other site
329726017580	ATP binding site [chemical binding]; other site
329726017581	Integrase core domain; Region: rve; pfam00665
329726017582	DDE domain; Region: DDE_Tnp_IS240; pfam13610
329726017583	Transposase; Region: DEDD_Tnp_IS110; pfam01548
329726017584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
329726017585	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
329726017586	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726017587	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726017588	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
329726017589	active site flap/lid [active]
329726017590	nucleophilic elbow; other site
329726017591	catalytic triad [active]
329726017592	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
329726017593	AAA ATPase domain; Region: AAA_16; pfam13191
329726017594	NACHT domain; Region: NACHT; pfam05729
329726017595	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726017596	structural tetrad; other site
329726017597	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726017598	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726017599	structural tetrad; other site
329726017600	WD40 repeats; Region: WD40; smart00320
329726017601	WD40 repeats; Region: WD40; smart00320
329726017602	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
329726017603	putative active site [active]
329726017604	putative catalytic triad [active]
329726017605	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
329726017606	Transposase; Region: DEDD_Tnp_IS110; pfam01548
329726017607	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
329726017608	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
329726017609	DDE domain; Region: DDE_Tnp_IS240; pfam13610
329726017610	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726017611	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726017612	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
329726017613	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017614	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017615	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017616	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017617	Protein of unknown function (DUF552); Region: DUF552; pfam04472
329726017618	Transglycosylase; Region: Transgly; pfam00912
329726017619	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
329726017620	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
329726017621	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
329726017622	AAA domain; Region: AAA_30; pfam13604
329726017623	Family description; Region: UvrD_C_2; pfam13538
329726017624	recombinase A; Provisional; Region: recA; PRK09354
329726017625	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
329726017626	hexamer interface [polypeptide binding]; other site
329726017627	Walker A motif; other site
329726017628	ATP binding site [chemical binding]; other site
329726017629	Walker B motif; other site
329726017630	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726017631	Coenzyme A binding pocket [chemical binding]; other site
329726017632	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
329726017633	RNB domain; Region: RNB; pfam00773
329726017634	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
329726017635	putative active site [active]
329726017636	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
329726017637	hypothetical protein; Provisional; Region: PRK10039
329726017638	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726017639	S-adenosylmethionine binding site [chemical binding]; other site
329726017640	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
329726017641	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
329726017642	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726017643	salt bridge; other site
329726017644	non-specific DNA binding site [nucleotide binding]; other site
329726017645	sequence-specific DNA binding site [nucleotide binding]; other site
329726017646	PAS domain S-box; Region: sensory_box; TIGR00229
329726017647	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726017648	putative active site [active]
329726017649	heme pocket [chemical binding]; other site
329726017650	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726017651	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726017652	dimer interface [polypeptide binding]; other site
329726017653	phosphorylation site [posttranslational modification]
329726017654	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726017655	ATP binding site [chemical binding]; other site
329726017656	Mg2+ binding site [ion binding]; other site
329726017657	G-X-G motif; other site
329726017658	Response regulator receiver domain; Region: Response_reg; pfam00072
329726017659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726017660	active site
329726017661	phosphorylation site [posttranslational modification]
329726017662	intermolecular recognition site; other site
329726017663	dimerization interface [polypeptide binding]; other site
329726017664	YHYH protein; Region: YHYH; pfam14240
329726017665	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
329726017666	Histidine kinase; Region: HisKA_3; pfam07730
329726017667	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
329726017668	ATP binding site [chemical binding]; other site
329726017669	Mg2+ binding site [ion binding]; other site
329726017670	G-X-G motif; other site
329726017671	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726017672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726017673	active site
329726017674	phosphorylation site [posttranslational modification]
329726017675	intermolecular recognition site; other site
329726017676	dimerization interface [polypeptide binding]; other site
329726017677	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
329726017678	DNA binding residues [nucleotide binding]
329726017679	dimerization interface [polypeptide binding]; other site
329726017680	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
329726017681	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
329726017682	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726017683	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
329726017684	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
329726017685	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726017686	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726017687	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726017688	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726017689	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726017690	dimer interface [polypeptide binding]; other site
329726017691	phosphorylation site [posttranslational modification]
329726017692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726017693	ATP binding site [chemical binding]; other site
329726017694	Mg2+ binding site [ion binding]; other site
329726017695	G-X-G motif; other site
329726017696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726017697	Response regulator receiver domain; Region: Response_reg; pfam00072
329726017698	active site
329726017699	phosphorylation site [posttranslational modification]
329726017700	intermolecular recognition site; other site
329726017701	dimerization interface [polypeptide binding]; other site
329726017702	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
329726017703	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726017704	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726017705	AAA-like domain; Region: AAA_10; pfam12846
329726017706	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
329726017707	Walker A motif; other site
329726017708	ATP binding site [chemical binding]; other site
329726017709	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726017710	ParB-like nuclease domain; Region: ParB; smart00470
329726017711	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720
329726017712	trimer interface [polypeptide binding]; other site
329726017713	putative Zn binding site [ion binding]; other site
329726017714	Predicted amidohydrolase [General function prediction only]; Region: COG0388
329726017715	Pyrococcus horikoshii Ph0642 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Ph0642_like; cd07577
329726017716	putative active site [active]
329726017717	catalytic triad [active]
329726017718	dimer interface [polypeptide binding]; other site
329726017719	putative tetramer interface [polypeptide binding]; other site
329726017720	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
329726017721	ssDNA binding site [nucleotide binding]; other site
329726017722	dimer interface [polypeptide binding]; other site
329726017723	tetramer (dimer of dimers) interface [polypeptide binding]; other site
329726017724	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
329726017725	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
329726017726	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726017727	Helix-turn-helix domain; Region: HTH_18; pfam12833
329726017728	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
329726017729	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
329726017730	DNA binding site [nucleotide binding]
329726017731	active site
329726017732	EamA-like transporter family; Region: EamA; pfam00892
329726017733	Transcriptional regulator [Transcription]; Region: LysR; COG0583
329726017734	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726017735	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
329726017736	putative effector binding pocket; other site
329726017737	dimerization interface [polypeptide binding]; other site
329726017738	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
329726017739	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270
329726017740	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
329726017741	putative NAD(P) binding site [chemical binding]; other site
329726017742	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726017743	LysR family transcriptional regulator; Provisional; Region: PRK14997
329726017744	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
329726017745	putative effector binding pocket; other site
329726017746	dimerization interface [polypeptide binding]; other site
329726017747	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
329726017748	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
329726017749	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
329726017750	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
329726017751	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
329726017752	NAD(P) binding site [chemical binding]; other site
329726017753	Uncharacterized conserved protein [Function unknown]; Region: COG2128
329726017754	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
329726017755	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
329726017756	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
329726017757	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
329726017758	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
329726017759	dsRNA binding site [nucleotide binding]; other site
329726017760	transposase; Validated; Region: PRK08181
329726017761	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726017762	Walker A motif; other site
329726017763	ATP binding site [chemical binding]; other site
329726017764	Integrase core domain; Region: rve; pfam00665
329726017765	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
329726017766	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
329726017767	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
329726017768	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
329726017769	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
329726017770	Integrase core domain; Region: rve; pfam00665
329726017771	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
329726017772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726017773	Walker A motif; other site
329726017774	ATP binding site [chemical binding]; other site
329726017775	putative transposase OrfB; Reviewed; Region: PHA02517
329726017776	HTH-like domain; Region: HTH_21; pfam13276
329726017777	Integrase core domain; Region: rve; pfam00665
329726017778	Integrase core domain; Region: rve_3; pfam13683
329726017779	Transposase; Region: HTH_Tnp_1; cl17663
329726017780	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
329726017781	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
329726017782	Ycf27; Reviewed; Region: orf27; CHL00148
329726017783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726017784	active site
329726017785	phosphorylation site [posttranslational modification]
329726017786	intermolecular recognition site; other site
329726017787	dimerization interface [polypeptide binding]; other site
329726017788	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726017789	DNA binding site [nucleotide binding]
329726017790	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
329726017791	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
329726017792	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
329726017793	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
329726017794	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
329726017795	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
329726017796	Phycobilisome protein; Region: Phycobilisome; cl08227
329726017797	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
329726017798	Phycobilisome protein; Region: Phycobilisome; cl08227
329726017799	Ycf27; Reviewed; Region: orf27; CHL00148
329726017800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726017801	active site
329726017802	phosphorylation site [posttranslational modification]
329726017803	intermolecular recognition site; other site
329726017804	dimerization interface [polypeptide binding]; other site
329726017805	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726017806	DNA binding site [nucleotide binding]
329726017807	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
329726017808	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
329726017809	ferrochelatase; Reviewed; Region: hemH; PRK00035
329726017810	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
329726017811	C-terminal domain interface [polypeptide binding]; other site
329726017812	active site
329726017813	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
329726017814	active site
329726017815	N-terminal domain interface [polypeptide binding]; other site
329726017816	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504
329726017817	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
329726017818	heme binding pocket [chemical binding]; other site
329726017819	heme ligand [chemical binding]; other site
329726017820	Phycobilisome protein; Region: Phycobilisome; cl08227
329726017821	HEAT repeats; Region: HEAT_2; pfam13646
329726017822	PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130
329726017823	HEAT repeats; Region: HEAT_2; pfam13646
329726017824	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
329726017825	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
329726017826	Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154
329726017827	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726017828	Homeodomain-like domain; Region: HTH_23; pfam13384
329726017829	Winged helix-turn helix; Region: HTH_29; pfam13551
329726017830	Winged helix-turn helix; Region: HTH_33; pfam13592
329726017831	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726017832	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726017833	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
329726017834	YcfA-like protein; Region: YcfA; pfam07927
329726017835	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726017836	active site
329726017837	DNA binding site [nucleotide binding]
329726017838	Int/Topo IB signature motif; other site
329726017839	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
329726017840	Uncharacterized conserved protein [Function unknown]; Region: COG5464
329726017841	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
329726017842	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
329726017843	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726017844	catalytic loop [active]
329726017845	iron binding site [ion binding]; other site
329726017846	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
329726017847	Transposase domain (DUF772); Region: DUF772; pfam05598
329726017848	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
329726017849	Domain of unknown function (DUF897); Region: DUF897; pfam05982
329726017850	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
329726017851	Nitrogen regulatory protein P-II; Region: P-II; smart00938
329726017852	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
329726017853	Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486
329726017854	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
329726017855	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
329726017856	Sulfatase; Region: Sulfatase; cl17466
329726017857	Uncharacterized conserved protein [Function unknown]; Region: COG5464
329726017858	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
329726017859	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
329726017860	Proline dehydrogenase; Region: Pro_dh; cl03282
329726017861	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
329726017862	delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
329726017863	Glutamate binding site [chemical binding]; other site
329726017864	homodimer interface [polypeptide binding]; other site
329726017865	NAD binding site [chemical binding]; other site
329726017866	catalytic residues [active]
329726017867	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726017868	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726017869	active site
329726017870	phosphorylation site [posttranslational modification]
329726017871	intermolecular recognition site; other site
329726017872	dimerization interface [polypeptide binding]; other site
329726017873	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726017874	Homeodomain-like domain; Region: HTH_23; pfam13384
329726017875	Winged helix-turn helix; Region: HTH_29; pfam13551
329726017876	Winged helix-turn helix; Region: HTH_33; pfam13592
329726017877	Homeodomain-like domain; Region: HTH_23; pfam13384
329726017878	Winged helix-turn helix; Region: HTH_29; pfam13551
329726017879	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
329726017880	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726017881	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726017882	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726017883	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
329726017884	Phycobilisome protein; Region: Phycobilisome; cl08227
329726017885	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726017886	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726017887	DNA binding site [nucleotide binding]
329726017888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726017889	active site
329726017890	dimerization interface [polypeptide binding]; other site
329726017891	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726017892	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726017893	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726017894	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
329726017895	ferrochelatase; Reviewed; Region: hemH; PRK00035
329726017896	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
329726017897	C-terminal domain interface [polypeptide binding]; other site
329726017898	active site
329726017899	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
329726017900	active site
329726017901	N-terminal domain interface [polypeptide binding]; other site
329726017902	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504
329726017903	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
329726017904	heme binding pocket [chemical binding]; other site
329726017905	heme ligand [chemical binding]; other site
329726017906	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726017907	putative transposase OrfB; Reviewed; Region: PHA02517
329726017908	HTH-like domain; Region: HTH_21; pfam13276
329726017909	Integrase core domain; Region: rve; pfam00665
329726017910	Integrase core domain; Region: rve_3; pfam13683
329726017911	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726017912	Phycobilisome protein; Region: Phycobilisome; cl08227
329726017913	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
329726017914	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
329726017915	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
329726017916	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
329726017917	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
329726017918	CpeS-like protein; Region: CpeS; pfam09367
329726017919	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726017920	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
329726017921	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726017922	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726017923	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
329726017924	DNA-binding interface [nucleotide binding]; DNA binding site
329726017925	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
329726017926	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726017927	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726017928	Cupin; Region: Cupin_6; pfam12852
329726017929	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726017930	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
329726017931	MAPEG family; Region: MAPEG; pfam01124
329726017932	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
329726017933	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
329726017934	NAD(P) binding site [chemical binding]; other site
329726017935	active site
329726017936	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726017937	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017938	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017939	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017940	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017941	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017942	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017943	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017944	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726017945	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017946	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017947	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017948	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726017949	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726017950	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
329726017951	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
329726017952	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
329726017953	catalytic residues [active]
329726017954	catalytic nucleophile [active]
329726017955	Transposase IS200 like; Region: Y1_Tnp; pfam01797
329726017956	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726017957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726017958	active site
329726017959	phosphorylation site [posttranslational modification]
329726017960	intermolecular recognition site; other site
329726017961	dimerization interface [polypeptide binding]; other site
329726017962	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726017963	DNA binding site [nucleotide binding]
329726017964	Response regulator receiver domain; Region: Response_reg; pfam00072
329726017965	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726017966	active site
329726017967	phosphorylation site [posttranslational modification]
329726017968	intermolecular recognition site; other site
329726017969	dimerization interface [polypeptide binding]; other site
329726017970	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726017971	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726017972	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
329726017973	ATP binding site [chemical binding]; other site
329726017974	substrate interface [chemical binding]; other site
329726017975	HEAT repeats; Region: HEAT_2; pfam13646
329726017976	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
329726017977	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
329726017978	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
329726017979	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
329726017980	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
329726017981	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
329726017982	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
329726017983	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
329726017984	putative amphipathic alpha helix; other site
329726017985	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
329726017986	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
329726017987	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726017988	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726017989	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726017990	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
329726017991	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726017992	P-loop; other site
329726017993	Magnesium ion binding site [ion binding]; other site
329726017994	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
329726017995	ParB-like nuclease domain; Region: ParBc; pfam02195
329726017996	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
329726017997	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
329726017998	NAD(P) binding pocket [chemical binding]; other site
329726017999	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
329726018000	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
329726018001	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
329726018002	active site
329726018003	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
329726018004	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
329726018005	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824
329726018006	putative hydrophobic ligand binding site [chemical binding]; other site
329726018007	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
329726018008	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726018009	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726018010	active site
329726018011	phosphorylation site [posttranslational modification]
329726018012	intermolecular recognition site; other site
329726018013	dimerization interface [polypeptide binding]; other site
329726018014	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726018015	DNA binding site [nucleotide binding]
329726018016	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
329726018017	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726018018	dimerization interface [polypeptide binding]; other site
329726018019	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726018020	dimer interface [polypeptide binding]; other site
329726018021	phosphorylation site [posttranslational modification]
329726018022	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726018023	ATP binding site [chemical binding]; other site
329726018024	Mg2+ binding site [ion binding]; other site
329726018025	G-X-G motif; other site
329726018026	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
329726018027	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
329726018028	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
329726018029	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726018030	active site
329726018031	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
329726018032	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726018033	non-specific DNA binding site [nucleotide binding]; other site
329726018034	salt bridge; other site
329726018035	sequence-specific DNA binding site [nucleotide binding]; other site
329726018036	Double zinc ribbon; Region: DZR; pfam12773
329726018037	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726018038	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
329726018039	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
329726018040	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
329726018041	putative active site [active]
329726018042	putative NTP binding site [chemical binding]; other site
329726018043	putative nucleic acid binding site [nucleotide binding]; other site
329726018044	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
329726018045	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726018046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
329726018047	hypothetical protein; Validated; Region: PRK09169
329726018048	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726018049	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
329726018050	IHF dimer interface [polypeptide binding]; other site
329726018051	IHF - DNA interface [nucleotide binding]; other site
329726018052	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
329726018053	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726018054	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726018055	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726018056	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726018057	DNA binding residues [nucleotide binding]
329726018058	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726018059	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726018060	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726018061	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726018062	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726018063	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726018064	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
329726018065	DinB superfamily; Region: DinB_2; pfam12867
329726018066	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
329726018067	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726018068	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
329726018069	IHF dimer interface [polypeptide binding]; other site
329726018070	IHF - DNA interface [nucleotide binding]; other site
329726018071	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726018072	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
329726018073	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726018074	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726018075	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726018076	DNA binding residues [nucleotide binding]
329726018077	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
329726018078	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
329726018079	IHF dimer interface [polypeptide binding]; other site
329726018080	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726018081	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
329726018082	anti sigma factor interaction site; other site
329726018083	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
329726018084	regulatory phosphorylation site [posttranslational modification]; other site
329726018085	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726018086	Response regulator receiver domain; Region: Response_reg; pfam00072
329726018087	active site
329726018088	phosphorylation site [posttranslational modification]
329726018089	intermolecular recognition site; other site
329726018090	dimerization interface [polypeptide binding]; other site
329726018091	Response regulator receiver domain; Region: Response_reg; pfam00072
329726018092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726018093	active site
329726018094	phosphorylation site [posttranslational modification]
329726018095	intermolecular recognition site; other site
329726018096	dimerization interface [polypeptide binding]; other site
329726018097	Response regulator receiver domain; Region: Response_reg; pfam00072
329726018098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726018099	active site
329726018100	phosphorylation site [posttranslational modification]
329726018101	intermolecular recognition site; other site
329726018102	dimerization interface [polypeptide binding]; other site
329726018103	Cache domain; Region: Cache_1; pfam02743
329726018104	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
329726018105	dimerization interface [polypeptide binding]; other site
329726018106	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726018107	dimer interface [polypeptide binding]; other site
329726018108	phosphorylation site [posttranslational modification]
329726018109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726018110	ATP binding site [chemical binding]; other site
329726018111	Mg2+ binding site [ion binding]; other site
329726018112	G-X-G motif; other site
329726018113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726018114	active site
329726018115	phosphorylation site [posttranslational modification]
329726018116	intermolecular recognition site; other site
329726018117	dimerization interface [polypeptide binding]; other site
329726018118	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
329726018119	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
329726018120	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
329726018121	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
329726018122	nucleotide binding site [chemical binding]; other site
329726018123	TrwC relaxase; Region: TrwC; pfam08751
329726018124	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
329726018125	AAA domain; Region: AAA_30; pfam13604
329726018126	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
329726018127	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
329726018128	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
329726018129	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
329726018130	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
329726018131	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
329726018132	RNB domain; Region: RNB; pfam00773
329726018133	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
329726018134	Protein of unknown function (DUF552); Region: DUF552; pfam04472
329726018135	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
329726018136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726018137	S-adenosylmethionine binding site [chemical binding]; other site
329726018138	Ycf27; Reviewed; Region: orf27; CHL00148
329726018139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726018140	active site
329726018141	phosphorylation site [posttranslational modification]
329726018142	intermolecular recognition site; other site
329726018143	dimerization interface [polypeptide binding]; other site
329726018144	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726018145	DNA binding site [nucleotide binding]
329726018146	Protein of unknown function (DUF552); Region: DUF552; cl00775
329726018147	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054
329726018148	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
329726018149	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
329726018150	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726018151	Coenzyme A binding pocket [chemical binding]; other site
329726018152	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726018153	ParB-like nuclease domain; Region: ParBc; cl02129
329726018154	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
329726018155	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726018156	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726018157	DNA binding residues [nucleotide binding]
329726018158	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726018159	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726018160	AAA-like domain; Region: AAA_10; pfam12846
329726018161	TPR repeat; Region: TPR_11; pfam13414
329726018162	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726018164	binding surface
329726018165	TPR motif; other site
329726018166	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018167	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018168	Tetratricopeptide repeat; Region: TPR_10; pfam13374
329726018169	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018170	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726018171	binding surface
329726018172	TPR motif; other site
329726018173	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018174	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
329726018175	AAA-like domain; Region: AAA_10; pfam12846
329726018176	Walker A motif; other site
329726018177	ATP binding site [chemical binding]; other site
329726018178	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
329726018179	Walker B motif; other site
329726018180	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
329726018181	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726018182	Walker A motif; other site
329726018183	ATP binding site [chemical binding]; other site
329726018184	TrwC relaxase; Region: TrwC; pfam08751
329726018185	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
329726018186	AAA domain; Region: AAA_30; pfam13604
329726018187	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
329726018188	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726018189	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
329726018190	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
329726018191	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
329726018192	GIY-YIG motif/motif A; other site
329726018193	active site
329726018194	catalytic site [active]
329726018195	metal binding site [ion binding]; metal-binding site
329726018196	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018197	Tetratricopeptide repeat; Region: TPR_10; pfam13374
329726018198	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018199	Tetratricopeptide repeat; Region: TPR_10; pfam13374
329726018200	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726018201	binding surface
329726018202	TPR motif; other site
329726018203	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018204	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018205	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726018206	TPR motif; other site
329726018207	binding surface
329726018208	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
329726018209	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
329726018210	active site
329726018211	interdomain interaction site; other site
329726018212	putative metal-binding site [ion binding]; other site
329726018213	nucleotide binding site [chemical binding]; other site
329726018214	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
329726018215	domain I; other site
329726018216	DNA binding groove [nucleotide binding]
329726018217	phosphate binding site [ion binding]; other site
329726018218	domain II; other site
329726018219	domain III; other site
329726018220	nucleotide binding site [chemical binding]; other site
329726018221	catalytic site [active]
329726018222	domain IV; other site
329726018223	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
329726018224	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
329726018225	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726018226	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726018227	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726018228	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726018229	DNA binding residues [nucleotide binding]
329726018230	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
329726018231	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726018232	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
329726018233	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
329726018234	putative dimer interface [polypeptide binding]; other site
329726018235	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
329726018236	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
329726018237	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
329726018238	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
329726018239	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
329726018240	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
329726018241	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726018242	non-specific DNA binding site [nucleotide binding]; other site
329726018243	salt bridge; other site
329726018244	sequence-specific DNA binding site [nucleotide binding]; other site
329726018245	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
329726018246	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
329726018247	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
329726018248	Protein of unknown function, DUF488; Region: DUF488; cl01246
329726018249	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
329726018250	Ligand Binding Site [chemical binding]; other site
329726018251	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
329726018252	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
329726018253	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726018254	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
329726018255	ligand binding site [chemical binding]; other site
329726018256	flexible hinge region; other site
329726018257	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
329726018258	putative switch regulator; other site
329726018259	non-specific DNA interactions [nucleotide binding]; other site
329726018260	DNA binding site [nucleotide binding]
329726018261	sequence specific DNA binding site [nucleotide binding]; other site
329726018262	putative cAMP binding site [chemical binding]; other site
329726018263	Response regulator receiver domain; Region: Response_reg; pfam00072
329726018264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726018265	active site
329726018266	phosphorylation site [posttranslational modification]
329726018267	intermolecular recognition site; other site
329726018268	dimerization interface [polypeptide binding]; other site
329726018269	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
329726018270	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726018271	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726018272	Magnesium ion binding site [ion binding]; other site
329726018273	Domain of unknown function (DUF1993); Region: DUF1993; cl01567
329726018274	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
329726018275	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
329726018276	molybdopterin cofactor binding site; other site
329726018277	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
329726018278	molybdopterin cofactor binding site; other site
329726018279	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
329726018280	Mechanosensitive ion channel; Region: MS_channel; pfam00924
329726018281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
329726018282	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
329726018283	rod shape-determining protein MreB; Provisional; Region: PRK13930
329726018284	MreB and similar proteins; Region: MreB_like; cd10225
329726018285	putative protofilament interaction site [polypeptide binding]; other site
329726018286	nucleotide binding site [chemical binding]; other site
329726018287	RodZ interaction site [polypeptide binding]; other site
329726018288	Mg binding site [ion binding]; other site
329726018289	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
329726018290	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
329726018291	putative active site [active]
329726018292	putative FMN binding site [chemical binding]; other site
329726018293	putative substrate binding site [chemical binding]; other site
329726018294	6-phosphofructokinase; Provisional; Region: PRK03202
329726018295	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
329726018296	active site
329726018297	ADP/pyrophosphate binding site [chemical binding]; other site
329726018298	dimerization interface [polypeptide binding]; other site
329726018299	allosteric effector site; other site
329726018300	fructose-1,6-bisphosphate binding site; other site
329726018301	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
329726018302	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
329726018303	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
329726018304	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
329726018305	putative dimer interface [polypeptide binding]; other site
329726018306	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
329726018307	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
329726018308	putative NAD(P) binding site [chemical binding]; other site
329726018309	putative substrate binding site [chemical binding]; other site
329726018310	catalytic Zn binding site [ion binding]; other site
329726018311	structural Zn binding site [ion binding]; other site
329726018312	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
329726018313	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
329726018314	Walker A/P-loop; other site
329726018315	ATP binding site [chemical binding]; other site
329726018316	Q-loop/lid; other site
329726018317	ABC transporter signature motif; other site
329726018318	Walker B; other site
329726018319	D-loop; other site
329726018320	H-loop/switch region; other site
329726018321	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
329726018322	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
329726018323	FtsX-like permease family; Region: FtsX; pfam02687
329726018324	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
329726018325	FtsX-like permease family; Region: FtsX; pfam02687
329726018326	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
329726018327	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
329726018328	HlyD family secretion protein; Region: HlyD_3; pfam13437
329726018329	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
329726018330	dimerization interface [polypeptide binding]; other site
329726018331	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
329726018332	ATP binding site [chemical binding]; other site
329726018333	phosphoenolpyruvate synthase; Validated; Region: PRK06464
329726018334	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
329726018335	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
329726018336	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
329726018337	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
329726018338	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
329726018339	alpha subunit interaction interface [polypeptide binding]; other site
329726018340	Walker A motif; other site
329726018341	ATP binding site [chemical binding]; other site
329726018342	Walker B motif; other site
329726018343	inhibitor binding site; inhibition site
329726018344	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
329726018345	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
329726018346	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
329726018347	gamma subunit interface [polypeptide binding]; other site
329726018348	epsilon subunit interface [polypeptide binding]; other site
329726018349	LBP interface [polypeptide binding]; other site
329726018350	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
329726018351	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
329726018352	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
329726018353	N-ATPase, AtpR subunit; Region: AtpR; pfam12966
329726018354	ATP synthase A chain; Region: ATP-synt_A; cl00413
329726018355	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
329726018356	alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322
329726018357	F0F1 ATP synthase subunit B; Provisional; Region: PRK14474
329726018358	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
329726018359	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
329726018360	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
329726018361	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
329726018362	Walker A motif; other site
329726018363	ATP binding site [chemical binding]; other site
329726018364	Walker B motif; other site
329726018365	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
329726018366	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
329726018367	core domain interface [polypeptide binding]; other site
329726018368	delta subunit interface [polypeptide binding]; other site
329726018369	epsilon subunit interface [polypeptide binding]; other site
329726018370	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
329726018371	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
329726018372	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
329726018373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726018374	active site
329726018375	phosphorylation site [posttranslational modification]
329726018376	intermolecular recognition site; other site
329726018377	dimerization interface [polypeptide binding]; other site
329726018378	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726018379	DNA binding site [nucleotide binding]
329726018380	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
329726018381	putative binding surface; other site
329726018382	active site
329726018383	Response regulator receiver domain; Region: Response_reg; pfam00072
329726018384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726018385	active site
329726018386	phosphorylation site [posttranslational modification]
329726018387	intermolecular recognition site; other site
329726018388	dimerization interface [polypeptide binding]; other site
329726018389	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726018390	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726018391	metal binding site [ion binding]; metal-binding site
329726018392	active site
329726018393	I-site; other site
329726018394	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
329726018395	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
329726018396	NodB motif; other site
329726018397	active site
329726018398	catalytic site [active]
329726018399	metal binding site [ion binding]; metal-binding site
329726018400	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726018401	Ligand Binding Site [chemical binding]; other site
329726018402	4Fe-4S binding domain; Region: Fer4; pfam00037
329726018403	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
329726018404	4Fe-4S binding domain; Region: Fer4; pfam00037
329726018405	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
329726018406	FMN binding site [chemical binding]; other site
329726018407	dimer interface [polypeptide binding]; other site
329726018408	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726018409	Ligand Binding Site [chemical binding]; other site
329726018410	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726018411	Ligand Binding Site [chemical binding]; other site
329726018412	bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571
329726018413	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
329726018414	putative dimer interface [polypeptide binding]; other site
329726018415	[2Fe-2S] cluster binding site [ion binding]; other site
329726018416	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
329726018417	dimer interface [polypeptide binding]; other site
329726018418	[2Fe-2S] cluster binding site [ion binding]; other site
329726018419	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
329726018420	SLBB domain; Region: SLBB; pfam10531
329726018421	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
329726018422	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
329726018423	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
329726018424	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
329726018425	substrate binding pocket [chemical binding]; other site
329726018426	membrane-bound complex binding site; other site
329726018427	hinge residues; other site
329726018428	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
329726018429	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
329726018430	catalytic loop [active]
329726018431	iron binding site [ion binding]; other site
329726018432	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
329726018433	4Fe-4S binding domain; Region: Fer4; pfam00037
329726018434	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
329726018435	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
329726018436	FOG: CBS domain [General function prediction only]; Region: COG0517
329726018437	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
329726018438	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
329726018439	FOG: CBS domain [General function prediction only]; Region: COG0517
329726018440	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
329726018441	CP12 domain; Region: CP12; pfam02672
329726018442	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
329726018443	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
329726018444	HupF/HypC family; Region: HupF_HypC; pfam01455
329726018445	Acylphosphatase; Region: Acylphosphatase; pfam00708
329726018446	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
329726018447	HypF finger; Region: zf-HYPF; pfam07503
329726018448	HypF finger; Region: zf-HYPF; pfam07503
329726018449	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
329726018450	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
329726018451	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
329726018452	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726018453	hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100
329726018454	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
329726018455	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
329726018456	nickel binding site [ion binding]; other site
329726018457	Coatomer WD associated region; Region: Coatomer_WDAD; pfam04053
329726018458	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
329726018459	UbiA prenyltransferase family; Region: UbiA; pfam01040
329726018460	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
329726018461	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
329726018462	dimerization interface [polypeptide binding]; other site
329726018463	putative ATP binding site [chemical binding]; other site
329726018464	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
329726018465	FOG: CBS domain [General function prediction only]; Region: COG0517
329726018466	FOG: CBS domain [General function prediction only]; Region: COG0517
329726018467	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
329726018468	PAS domain; Region: PAS_9; pfam13426
329726018469	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726018470	putative active site [active]
329726018471	heme pocket [chemical binding]; other site
329726018472	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
329726018473	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
329726018474	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726018475	PAS fold; Region: PAS_3; pfam08447
329726018476	putative active site [active]
329726018477	heme pocket [chemical binding]; other site
329726018478	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726018479	PAS fold; Region: PAS_3; pfam08447
329726018480	putative active site [active]
329726018481	heme pocket [chemical binding]; other site
329726018482	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
329726018483	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
329726018484	putative active site [active]
329726018485	heme pocket [chemical binding]; other site
329726018486	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
329726018487	dimer interface [polypeptide binding]; other site
329726018488	phosphorylation site [posttranslational modification]
329726018489	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726018490	ATP binding site [chemical binding]; other site
329726018491	Mg2+ binding site [ion binding]; other site
329726018492	G-X-G motif; other site
329726018493	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
329726018494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726018495	active site
329726018496	phosphorylation site [posttranslational modification]
329726018497	intermolecular recognition site; other site
329726018498	dimerization interface [polypeptide binding]; other site
329726018499	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
329726018500	homodimer interface [polypeptide binding]; other site
329726018501	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
329726018502	active site pocket [active]
329726018503	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
329726018504	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726018505	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726018506	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726018507	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726018508	DNA binding residues [nucleotide binding]
329726018509	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273
329726018510	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
329726018511	putative NAD(P) binding site [chemical binding]; other site
329726018512	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
329726018513	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
329726018514	oligomerisation interface [polypeptide binding]; other site
329726018515	mobile loop; other site
329726018516	roof hairpin; other site
329726018517	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
329726018518	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
329726018519	ring oligomerisation interface [polypeptide binding]; other site
329726018520	ATP/Mg binding site [chemical binding]; other site
329726018521	stacking interactions; other site
329726018522	hinge regions; other site
329726018523	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
329726018524	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
329726018525	MgtC family; Region: MgtC; pfam02308
329726018526	Predicted membrane protein [Function unknown]; Region: COG3174
329726018527	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
329726018528	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726018529	Ligand Binding Site [chemical binding]; other site
329726018530	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
329726018531	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726018532	active site
329726018533	DNA binding site [nucleotide binding]
329726018534	Int/Topo IB signature motif; other site
329726018535	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
329726018536	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726018537	non-specific DNA binding site [nucleotide binding]; other site
329726018538	salt bridge; other site
329726018539	sequence-specific DNA binding site [nucleotide binding]; other site
329726018540	Double zinc ribbon; Region: DZR; pfam12773
329726018541	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726018542	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
329726018543	Integrase core domain; Region: rve; pfam00665
329726018544	transposase; Validated; Region: PRK08181
329726018545	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726018546	Walker A motif; other site
329726018547	ATP binding site [chemical binding]; other site
329726018548	Predicted DNA-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG1571
329726018549	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
329726018550	Ligand Binding Site [chemical binding]; other site
329726018551	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
329726018552	FtsH Extracellular; Region: FtsH_ext; pfam06480
329726018553	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
329726018554	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726018555	Walker A motif; other site
329726018556	ATP binding site [chemical binding]; other site
329726018557	Walker B motif; other site
329726018558	arginine finger; other site
329726018559	Peptidase family M41; Region: Peptidase_M41; pfam01434
329726018560	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
329726018561	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
329726018562	NAD(P) binding site [chemical binding]; other site
329726018563	putative active site [active]
329726018564	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
329726018565	Pheophorbide a oxygenase; Region: PaO; pfam08417
329726018566	Methyltransferase domain; Region: Methyltransf_31; pfam13847
329726018567	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726018568	S-adenosylmethionine binding site [chemical binding]; other site
329726018569	hypothetical protein; Provisional; Region: PRK05421
329726018570	putative catalytic site [active]
329726018571	putative metal binding site [ion binding]; other site
329726018572	putative phosphate binding site [ion binding]; other site
329726018573	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
329726018574	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
329726018575	putative active site [active]
329726018576	catalytic site [active]
329726018577	Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161
329726018578	putative active site [active]
329726018579	catalytic site [active]
329726018580	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
329726018581	intracellular protease, PfpI family; Region: PfpI; TIGR01382
329726018582	conserved cys residue [active]
329726018583	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
329726018584	dinuclear metal binding motif [ion binding]; other site
329726018585	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
329726018586	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
329726018587	putative acyl-acceptor binding pocket; other site
329726018588	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
329726018589	PGAP1-like protein; Region: PGAP1; pfam07819
329726018590	Predicted transporter component [General function prediction only]; Region: COG2391
329726018591	Sulphur transport; Region: Sulf_transp; pfam04143
329726018592	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
329726018593	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
329726018594	high affinity sulphate transporter 1; Region: sulP; TIGR00815
329726018595	Sulfate transporter family; Region: Sulfate_transp; pfam00916
329726018596	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
329726018597	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
329726018598	active site residue [active]
329726018599	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
329726018600	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
329726018601	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
329726018602	dimer interface [polypeptide binding]; other site
329726018603	PYR/PP interface [polypeptide binding]; other site
329726018604	TPP binding site [chemical binding]; other site
329726018605	substrate binding site [chemical binding]; other site
329726018606	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
329726018607	Domain of unknown function; Region: EKR; smart00890
329726018608	4Fe-4S binding domain; Region: Fer4_6; pfam12837
329726018609	4Fe-4S binding domain; Region: Fer4; pfam00037
329726018610	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
329726018611	TPP-binding site [chemical binding]; other site
329726018612	dimer interface [polypeptide binding]; other site
329726018613	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726018614	active site
329726018615	DNA binding site [nucleotide binding]
329726018616	Int/Topo IB signature motif; other site
329726018617	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
329726018618	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
329726018619	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
329726018620	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
329726018621	FMN binding site [chemical binding]; other site
329726018622	active site
329726018623	substrate binding site [chemical binding]; other site
329726018624	catalytic residue [active]
329726018625	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726018626	light-harvesting-like protein 3; Provisional; Region: PLN00014
329726018627	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
329726018628	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
329726018629	recombinase A; Provisional; Region: recA; PRK09354
329726018630	recA bacterial DNA recombination protein; Region: RecA; cl17211
329726018631	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_17; cd08356
329726018632	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726018633	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054
329726018634	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
329726018635	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726018636	Walker A/P-loop; other site
329726018637	ATP binding site [chemical binding]; other site
329726018638	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
329726018639	Transposase domain (DUF772); Region: DUF772; pfam05598
329726018640	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
329726018641	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
329726018642	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726018643	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
329726018644	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726018645	P-loop; other site
329726018646	Magnesium ion binding site [ion binding]; other site
329726018647	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726018648	active site
329726018649	DNA binding site [nucleotide binding]
329726018650	Int/Topo IB signature motif; other site
329726018651	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
329726018652	Catalytic NodB homology domain of uncharacterized chitin deacetylases and hypothetical proteins; Region: CE4_NodB_like_2; cd10958
329726018653	NodB motif; other site
329726018654	putative active site [active]
329726018655	putative catalytic site [active]
329726018656	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726018657	active site
329726018658	Int/Topo IB signature motif; other site
329726018659	unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional; Region: PRK14966
329726018660	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
329726018661	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726018662	salt bridge; other site
329726018663	non-specific DNA binding site [nucleotide binding]; other site
329726018664	sequence-specific DNA binding site [nucleotide binding]; other site
329726018665	KilA-N domain; Region: KilA-N; pfam04383
329726018666	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726018667	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
329726018668	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726018669	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726018670	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726018671	DNA binding residues [nucleotide binding]
329726018672	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726018673	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
329726018674	Homeodomain-like domain; Region: HTH_23; pfam13384
329726018675	Winged helix-turn helix; Region: HTH_29; pfam13551
329726018676	Winged helix-turn helix; Region: HTH_33; pfam13592
329726018677	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726018678	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726018679	Helix-turn-helix domain; Region: HTH_37; pfam13744
329726018680	non-specific DNA binding site [nucleotide binding]; other site
329726018681	salt bridge; other site
329726018682	sequence-specific DNA binding site [nucleotide binding]; other site
329726018683	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
329726018684	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726018685	RelB antitoxin; Region: RelB; cl01171
329726018686	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
329726018687	Walker A motif; other site
329726018688	ATP binding site [chemical binding]; other site
329726018689	Walker B motif; other site
329726018690	TrwC relaxase; Region: TrwC; pfam08751
329726018691	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
329726018692	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
329726018693	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
329726018694	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
329726018695	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
329726018696	Integrase core domain; Region: rve; pfam00665
329726018697	transposase; Validated; Region: PRK08181
329726018698	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726018699	Walker A motif; other site
329726018700	ATP binding site [chemical binding]; other site
329726018701	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726018702	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726018703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
329726018704	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726018705	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726018706	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
329726018707	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
329726018708	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
329726018709	oligomeric interface; other site
329726018710	putative active site [active]
329726018711	homodimer interface [polypeptide binding]; other site
329726018712	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
329726018713	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726018714	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726018715	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726018716	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726018717	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726018718	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726018719	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
329726018720	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
329726018721	ParA-like protein; Provisional; Region: PHA02518
329726018722	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726018723	P-loop; other site
329726018724	Magnesium ion binding site [ion binding]; other site
329726018725	ParB-like nuclease domain; Region: ParB; smart00470
329726018726	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
329726018727	Esterase/lipase [General function prediction only]; Region: COG1647
329726018728	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
329726018729	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
329726018730	RNB domain; Region: RNB; pfam00773
329726018731	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
329726018732	dsRNA binding site [nucleotide binding]; other site
329726018733	Cytochrome P450; Region: p450; cl12078
329726018734	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
329726018735	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
329726018736	classical (c) SDRs; Region: SDR_c; cd05233
329726018737	NAD(P) binding site [chemical binding]; other site
329726018738	active site
329726018739	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
329726018740	Predicted transcriptional regulators [Transcription]; Region: COG1733
329726018741	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
329726018742	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
329726018743	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
329726018744	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
329726018745	VCBS repeat; Region: VCBS_repeat; TIGR01965
329726018746	NACHT domain; Region: NACHT; pfam05729
329726018747	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726018748	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726018749	structural tetrad; other site
329726018750	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726018751	structural tetrad; other site
329726018752	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
329726018753	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726018754	active site
329726018755	Int/Topo IB signature motif; other site
329726018756	DNA binding site [nucleotide binding]
329726018757	Plant protein of unknown function (DUF946); Region: DUF946; pfam06101
329726018758	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
329726018759	Transposase, Mutator family; Region: Transposase_mut; pfam00872
329726018760	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726018761	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726018762	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
329726018763	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
329726018764	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
329726018765	recombinase A; Provisional; Region: recA; PRK09354
329726018766	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
329726018767	hexamer interface [polypeptide binding]; other site
329726018768	Walker A motif; other site
329726018769	ATP binding site [chemical binding]; other site
329726018770	Walker B motif; other site
329726018771	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
329726018772	RNB domain; Region: RNB; pfam00773
329726018773	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
329726018774	dsRNA binding site [nucleotide binding]; other site
329726018775	GIY-YIG type nucleases (URI domain); Region: GIYc; smart00465
329726018776	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
329726018777	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
329726018778	Staphylococcal nuclease homologues; Region: SNc; smart00318
329726018779	Catalytic site; other site
329726018780	Staphylococcal nuclease homologue; Region: SNase; pfam00565
329726018781	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
329726018782	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
329726018783	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726018784	Walker A motif; other site
329726018785	ATP binding site [chemical binding]; other site
329726018786	Walker B motif; other site
329726018787	arginine finger; other site
329726018788	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425
329726018789	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
329726018790	metal ion-dependent adhesion site (MIDAS); other site
329726018791	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726018792	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726018793	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
329726018794	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726018795	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726018796	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726018797	DNA binding residues [nucleotide binding]
329726018798	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
329726018799	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
329726018800	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726018801	Walker A motif; other site
329726018802	ATP binding site [chemical binding]; other site
329726018803	Integrase core domain; Region: rve; pfam00665
329726018804	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
329726018805	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
329726018806	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726018807	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726018808	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
329726018809	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726018810	Coenzyme A binding pocket [chemical binding]; other site
329726018811	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
329726018812	Strictosidine synthase; Region: Str_synth; pfam03088
329726018813	TrwC relaxase; Region: TrwC; pfam08751
329726018814	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
329726018815	AAA domain; Region: AAA_30; pfam13604
329726018816	AAA domain; Region: AAA_22; pfam13401
329726018817	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
329726018818	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726018819	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726018820	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726018821	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726018822	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726018823	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726018824	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
329726018825	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
329726018826	AAA-like domain; Region: AAA_10; pfam12846
329726018827	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
329726018828	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726018829	binding surface
329726018830	TPR motif; other site
329726018831	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018832	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726018834	binding surface
329726018835	TPR motif; other site
329726018836	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018837	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726018839	binding surface
329726018840	TPR motif; other site
329726018841	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018842	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726018844	binding surface
329726018845	TPR motif; other site
329726018846	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726018847	AAA-like domain; Region: AAA_10; pfam12846
329726018848	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726018849	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726018850	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
329726018851	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726018852	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726018853	DNA binding residues [nucleotide binding]
329726018854	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
329726018855	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
329726018856	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
329726018857	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
329726018858	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
329726018859	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
329726018860	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
329726018861	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
329726018862	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726018863	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726018864	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726018865	DNA binding residues [nucleotide binding]
329726018866	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
329726018867	Transposase domain (DUF772); Region: DUF772; pfam05598
329726018868	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
329726018869	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
329726018870	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
329726018871	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
329726018872	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
329726018873	putative active site [active]
329726018874	putative NTP binding site [chemical binding]; other site
329726018875	putative nucleic acid binding site [nucleotide binding]; other site
329726018876	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
329726018877	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
329726018878	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
329726018879	active site
329726018880	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
329726018881	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
329726018882	Transposase domain (DUF772); Region: DUF772; pfam05598
329726018883	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
329726018884	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
329726018885	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
329726018886	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
329726018887	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
329726018888	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
329726018889	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
329726018890	active site
329726018891	motif I; other site
329726018892	motif II; other site
329726018893	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
329726018894	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
329726018895	Protein of unknown function, DUF488; Region: DUF488; cl01246
329726018896	Response regulator receiver domain; Region: Response_reg; pfam00072
329726018897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726018898	active site
329726018899	phosphorylation site [posttranslational modification]
329726018900	intermolecular recognition site; other site
329726018901	dimerization interface [polypeptide binding]; other site
329726018902	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
329726018903	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
329726018904	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
329726018905	non-specific DNA interactions [nucleotide binding]; other site
329726018906	DNA binding site [nucleotide binding]
329726018907	sequence specific DNA binding site [nucleotide binding]; other site
329726018908	putative cAMP binding site [chemical binding]; other site
329726018909	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
329726018910	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
329726018911	P loop; other site
329726018912	Nucleotide binding site [chemical binding]; other site
329726018913	DTAP/Switch II; other site
329726018914	Switch I; other site
329726018915	ParB-like nuclease domain; Region: ParB; smart00470
329726018916	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
329726018917	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
329726018918	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726018919	ATP binding site [chemical binding]; other site
329726018920	putative Mg++ binding site [ion binding]; other site
329726018921	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726018922	nucleotide binding region [chemical binding]; other site
329726018923	ATP-binding site [chemical binding]; other site
329726018924	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
329726018925	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
329726018926	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
329726018927	THF binding site; other site
329726018928	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
329726018929	substrate binding site [chemical binding]; other site
329726018930	THF binding site; other site
329726018931	zinc-binding site [ion binding]; other site
329726018932	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
329726018933	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
329726018934	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
329726018935	putative dimerization interface [polypeptide binding]; other site
329726018936	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
329726018937	ATP cone domain; Region: ATP-cone; pfam03477
329726018938	Class I ribonucleotide reductase; Region: RNR_I; cd01679
329726018939	active site
329726018940	dimer interface [polypeptide binding]; other site
329726018941	catalytic residues [active]
329726018942	effector binding site; other site
329726018943	R2 peptide binding site; other site
329726018944	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
329726018945	dimer interface [polypeptide binding]; other site
329726018946	putative radical transfer pathway; other site
329726018947	diiron center [ion binding]; other site
329726018948	tyrosyl radical; other site
329726018949	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
329726018950	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
329726018951	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
329726018952	acyl-CoA synthetase; Validated; Region: PRK05850
329726018953	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
329726018954	acyl-activating enzyme (AAE) consensus motif; other site
329726018955	active site
329726018956	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
329726018957	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726018958	ATP binding site [chemical binding]; other site
329726018959	putative Mg++ binding site [ion binding]; other site
329726018960	helicase superfamily c-terminal domain; Region: HELICc; smart00490
329726018961	ATP-binding site [chemical binding]; other site
329726018962	hypothetical protein; Validated; Region: PRK00029
329726018963	Uncharacterized conserved protein [Function unknown]; Region: COG0397
329726018964	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
329726018965	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726018966	Transposase [DNA replication, recombination, and repair]; Region: COG5433
329726018967	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
329726018968	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
329726018969	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
329726018970	putative active site [active]
329726018971	putative NTP binding site [chemical binding]; other site
329726018972	putative nucleic acid binding site [nucleotide binding]; other site
329726018973	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
329726018974	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
329726018975	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
329726018976	active site
329726018977	Transposase domain (DUF772); Region: DUF772; pfam05598
329726018978	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
329726018979	Transposase [DNA replication, recombination, and repair]; Region: COG5433
329726018980	DDE superfamily endonuclease; Region: DDE_3; pfam13358
329726018981	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
329726018982	Transposase; Region: HTH_Tnp_IS630; pfam01710
329726018983	Helix-turn-helix domain; Region: HTH_28; pfam13518
329726018984	hypothetical protein; Validated; Region: PRK00029
329726018985	Domain of unknown function (DUF336); Region: DUF336; pfam03928
329726018986	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
329726018987	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
329726018988	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
329726018989	Walker A motif; other site
329726018990	ATP binding site [chemical binding]; other site
329726018991	Walker B motif; other site
329726018992	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
329726018993	putative DNA binding helix; other site
329726018994	metal binding site 2 [ion binding]; metal-binding site
329726018995	metal binding site 1 [ion binding]; metal-binding site
329726018996	dimer interface [polypeptide binding]; other site
329726018997	structural Zn2+ binding site [ion binding]; other site
329726018998	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
329726018999	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
329726019000	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
329726019001	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726019002	metal binding site 2 [ion binding]; metal-binding site
329726019003	putative DNA binding helix; other site
329726019004	metal binding site 1 [ion binding]; metal-binding site
329726019005	dimer interface [polypeptide binding]; other site
329726019006	structural Zn2+ binding site [ion binding]; other site
329726019007	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726019008	metal binding site 2 [ion binding]; metal-binding site
329726019009	putative DNA binding helix; other site
329726019010	metal binding site 1 [ion binding]; metal-binding site
329726019011	dimer interface [polypeptide binding]; other site
329726019012	structural Zn2+ binding site [ion binding]; other site
329726019013	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
329726019014	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
329726019015	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
329726019016	G1 box; other site
329726019017	GTP/Mg2+ binding site [chemical binding]; other site
329726019018	G2 box; other site
329726019019	Switch I region; other site
329726019020	G3 box; other site
329726019021	Switch II region; other site
329726019022	G4 box; other site
329726019023	G5 box; other site
329726019024	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
329726019025	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
329726019026	metal binding site 2 [ion binding]; metal-binding site
329726019027	putative DNA binding helix; other site
329726019028	metal binding site 1 [ion binding]; metal-binding site
329726019029	dimer interface [polypeptide binding]; other site
329726019030	structural Zn2+ binding site [ion binding]; other site
329726019031	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
329726019032	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
329726019033	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
329726019034	active site
329726019035	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
329726019036	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
329726019037	active site
329726019038	HIGH motif; other site
329726019039	KMSKS motif; other site
329726019040	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
329726019041	tRNA binding surface [nucleotide binding]; other site
329726019042	anticodon binding site; other site
329726019043	Protein of unknown function (DUF448); Region: DUF448; pfam04296
329726019044	putative RNA binding cleft [nucleotide binding]; other site
329726019045	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726019046	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726019047	active site
329726019048	ATP binding site [chemical binding]; other site
329726019049	substrate binding site [chemical binding]; other site
329726019050	activation loop (A-loop); other site
329726019051	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
329726019052	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726019053	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726019054	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
329726019055	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
329726019056	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
329726019057	FMN binding site [chemical binding]; other site
329726019058	active site
329726019059	substrate binding site [chemical binding]; other site
329726019060	catalytic residue [active]
329726019061	Peptidase family M48; Region: Peptidase_M48; pfam01435
329726019062	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
329726019063	MPT binding site; other site
329726019064	trimer interface [polypeptide binding]; other site
329726019065	SprT homologues; Region: SprT; cl01182
329726019066	Protein of unknown function (DUF552); Region: DUF552; pfam04472
329726019067	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
329726019068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726019069	S-adenosylmethionine binding site [chemical binding]; other site
329726019070	Ycf27; Reviewed; Region: orf27; CHL00148
329726019071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
329726019072	active site
329726019073	phosphorylation site [posttranslational modification]
329726019074	intermolecular recognition site; other site
329726019075	dimerization interface [polypeptide binding]; other site
329726019076	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
329726019077	DNA binding site [nucleotide binding]
329726019078	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054
329726019079	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
329726019080	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
329726019081	Cytochrome P450; Region: p450; pfam00067
329726019082	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
329726019083	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
329726019084	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
329726019085	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
329726019086	Surface antigen; Region: Bac_surface_Ag; pfam01103
329726019087	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019088	CHAT domain; Region: CHAT; cl17868
329726019089	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
329726019090	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726019091	active site
329726019092	ATP binding site [chemical binding]; other site
329726019093	substrate binding site [chemical binding]; other site
329726019094	activation loop (A-loop); other site
329726019095	TPR repeat; Region: TPR_11; pfam13414
329726019096	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019097	TPR motif; other site
329726019098	binding surface
329726019099	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019100	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019101	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019102	binding surface
329726019103	TPR motif; other site
329726019104	TPR repeat; Region: TPR_11; pfam13414
329726019105	AAA ATPase domain; Region: AAA_16; pfam13191
329726019106	AAA domain; Region: AAA_22; pfam13401
329726019107	Walker A motif; other site
329726019108	ATP binding site [chemical binding]; other site
329726019109	Walker B motif; other site
329726019110	ParB-like nuclease domain; Region: ParBc; cl02129
329726019111	ParB-like nuclease domain; Region: ParBc; cl02129
329726019112	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
329726019113	nucleotide binding site [chemical binding]; other site
329726019114	Domain of unknown function DUF87; Region: DUF87; pfam01935
329726019115	AAA-like domain; Region: AAA_10; pfam12846
329726019116	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
329726019117	catalytic residue [active]
329726019118	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726019119	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726019120	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
329726019121	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
329726019122	Integrase core domain; Region: rve; pfam00665
329726019123	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
329726019124	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726019125	Walker A motif; other site
329726019126	ATP binding site [chemical binding]; other site
329726019127	Homeodomain-like domain; Region: HTH_23; pfam13384
329726019128	Winged helix-turn helix; Region: HTH_29; pfam13551
329726019129	Homeodomain-like domain; Region: HTH_32; pfam13565
329726019130	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
329726019131	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
329726019132	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
329726019133	AAA domain; Region: AAA_30; pfam13604
329726019134	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
329726019135	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
329726019136	nucleotide binding site [chemical binding]; other site
329726019137	EthD domain; Region: EthD; pfam07110
329726019138	Haemolytic domain; Region: Haemolytic; pfam01809
329726019139	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
329726019140	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
329726019141	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726019142	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
329726019143	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726019144	DNA binding residues [nucleotide binding]
329726019145	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726019146	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
329726019147	dimer interface [polypeptide binding]; other site
329726019148	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726019149	ligand binding site [chemical binding]; other site
329726019150	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019151	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726019152	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019153	Nuclease-related domain; Region: NERD; pfam08378
329726019154	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726019155	non-specific DNA binding site [nucleotide binding]; other site
329726019156	salt bridge; other site
329726019157	sequence-specific DNA binding site [nucleotide binding]; other site
329726019158	Transposase domain (DUF772); Region: DUF772; pfam05598
329726019159	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
329726019160	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
329726019161	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
329726019162	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
329726019163	putative active site [active]
329726019164	putative NTP binding site [chemical binding]; other site
329726019165	putative nucleic acid binding site [nucleotide binding]; other site
329726019166	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
329726019167	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
329726019168	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
329726019169	active site
329726019170	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726019171	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
329726019172	active site
329726019173	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019174	Tetratricopeptide repeat; Region: TPR_9; pfam13371
329726019175	TPR motif; other site
329726019176	haemagglutination activity domain; Region: Haemagg_act; pfam05860
329726019177	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726019178	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
329726019179	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
329726019180	NB-ARC domain; Region: NB-ARC; pfam00931
329726019181	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019183	binding surface
329726019184	TPR motif; other site
329726019185	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019186	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019187	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019188	binding surface
329726019189	TPR motif; other site
329726019190	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019191	CHAT domain; Region: CHAT; cl17868
329726019192	TIR domain; Region: TIR_2; pfam13676
329726019193	NB-ARC domain; Region: NB-ARC; pfam00931
329726019194	WD40 repeats; Region: WD40; smart00320
329726019195	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726019196	structural tetrad; other site
329726019197	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726019198	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726019199	structural tetrad; other site
329726019200	WD domain, G-beta repeat; Region: WD40; pfam00400
329726019201	RDD family; Region: RDD; pfam06271
329726019202	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726019203	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726019204	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
329726019205	Walker A motif; other site
329726019206	ATP binding site [chemical binding]; other site
329726019207	Walker B motif; other site
329726019208	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726019209	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726019210	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726019211	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726019212	Uncharacterized conserved protein [Function unknown]; Region: COG1262
329726019213	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
329726019214	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
329726019215	dsRNA binding site [nucleotide binding]; other site
329726019216	ParA-like protein; Provisional; Region: PHA02518
329726019217	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726019218	P-loop; other site
329726019219	Magnesium ion binding site [ion binding]; other site
329726019220	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
329726019221	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726019222	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726019223	TPR repeat; Region: TPR_11; pfam13414
329726019224	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019225	binding surface
329726019226	TPR motif; other site
329726019227	TPR repeat; Region: TPR_11; pfam13414
329726019228	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019229	binding surface
329726019230	TPR motif; other site
329726019231	TPR repeat; Region: TPR_11; pfam13414
329726019232	TPR repeat; Region: TPR_11; pfam13414
329726019233	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
329726019234	Interferon-induced transmembrane protein; Region: CD225; pfam04505
329726019235	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
329726019236	active site
329726019237	catalytic site [active]
329726019238	substrate binding site [chemical binding]; other site
329726019239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
329726019240	Integrase core domain; Region: rve; pfam00665
329726019241	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
329726019242	Ion channel; Region: Ion_trans_2; pfam07885
329726019243	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
329726019244	TrkA-N domain; Region: TrkA_N; pfam02254
329726019245	TrkA-C domain; Region: TrkA_C; pfam02080
329726019246	ammonium transporter; Region: amt; TIGR00836
329726019247	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
329726019248	Na binding site [ion binding]; other site
329726019249	putative glycosylation site [posttranslational modification]; other site
329726019250	putative glycosylation site [posttranslational modification]; other site
329726019251	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
329726019252	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
329726019253	SLBB domain; Region: SLBB; pfam10531
329726019254	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
329726019255	SLBB domain; Region: SLBB; pfam10531
329726019256	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
329726019257	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
329726019258	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
329726019259	protein binding site [polypeptide binding]; other site
329726019260	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
329726019261	putative catalytic site [active]
329726019262	putative metal binding site [ion binding]; other site
329726019263	putative phosphate binding site [ion binding]; other site
329726019264	Lamin Tail Domain; Region: LTD; pfam00932
329726019265	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
329726019266	Walker A/P-loop; other site
329726019267	ATP binding site [chemical binding]; other site
329726019268	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
329726019269	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726019270	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726019271	DNA binding residues [nucleotide binding]
329726019272	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
329726019273	AAA-like domain; Region: AAA_10; pfam12846
329726019274	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
329726019275	Apoptosis inhibitory protein 5 (API5); Region: API5; pfam05918
329726019276	Domain of unknown function DUF29; Region: DUF29; pfam01724
329726019277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
329726019278	Methyltransferase domain; Region: Methyltransf_23; pfam13489
329726019279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
329726019280	S-adenosylmethionine binding site [chemical binding]; other site
329726019281	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
329726019282	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
329726019283	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726019284	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726019285	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
329726019286	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
329726019287	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
329726019288	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
329726019289	short chain dehydrogenase; Provisional; Region: PRK06180
329726019290	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
329726019291	NADP binding site [chemical binding]; other site
329726019292	active site
329726019293	steroid binding site; other site
329726019294	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
329726019295	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726019296	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726019297	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
329726019298	salt bridge; other site
329726019299	non-specific DNA binding site [nucleotide binding]; other site
329726019300	sequence-specific DNA binding site [nucleotide binding]; other site
329726019301	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
329726019302	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
329726019303	short chain dehydrogenase; Validated; Region: PRK06182
329726019304	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
329726019305	NADP binding site [chemical binding]; other site
329726019306	active site
329726019307	steroid binding site; other site
329726019308	classical (c) SDRs; Region: SDR_c; cd05233
329726019309	NAD(P) binding site [chemical binding]; other site
329726019310	active site
329726019311	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
329726019312	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
329726019313	TrwC relaxase; Region: TrwC; pfam08751
329726019314	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
329726019315	AAA domain; Region: AAA_30; pfam13604
329726019316	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
329726019317	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726019318	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726019319	active site
329726019320	ATP binding site [chemical binding]; other site
329726019321	substrate binding site [chemical binding]; other site
329726019322	activation loop (A-loop); other site
329726019323	phosphate binding protein; Region: ptsS_2; TIGR02136
329726019324	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
329726019325	Mg binding site [ion binding]; other site
329726019326	nucleotide binding site [chemical binding]; other site
329726019327	putative protofilament interface [polypeptide binding]; other site
329726019328	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
329726019329	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
329726019330	Catalytic domain of Protein Kinases; Region: PKc; cd00180
329726019331	active site
329726019332	ATP binding site [chemical binding]; other site
329726019333	substrate binding site [chemical binding]; other site
329726019334	activation loop (A-loop); other site
329726019335	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
329726019336	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
329726019337	active site
329726019338	The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693
329726019339	Integrase core domain; Region: rve; pfam00665
329726019340	transposase; Validated; Region: PRK08181
329726019341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726019342	Walker A motif; other site
329726019343	ATP binding site [chemical binding]; other site
329726019344	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
329726019345	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
329726019346	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
329726019347	NAD binding site [chemical binding]; other site
329726019348	homotetramer interface [polypeptide binding]; other site
329726019349	homodimer interface [polypeptide binding]; other site
329726019350	active site
329726019351	substrate binding site [chemical binding]; other site
329726019352	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
329726019353	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
329726019354	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
329726019355	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726019356	Domain of unknown function DUF29; Region: DUF29; pfam01724
329726019357	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726019358	non-specific DNA binding site [nucleotide binding]; other site
329726019359	salt bridge; other site
329726019360	sequence-specific DNA binding site [nucleotide binding]; other site
329726019361	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
329726019362	Active Sites [active]
329726019363	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
329726019364	Haemolytic domain; Region: Haemolytic; pfam01809
329726019365	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
329726019366	dimer interface [polypeptide binding]; other site
329726019367	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
329726019368	ligand binding site [chemical binding]; other site
329726019369	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
329726019370	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
329726019371	Catalytic site [active]
329726019372	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
329726019373	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
329726019374	active site
329726019375	DNA binding site [nucleotide binding]
329726019376	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
329726019377	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726019378	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019379	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019380	Ion channel; Region: Ion_trans_2; pfam07885
329726019381	AAA ATPase domain; Region: AAA_16; pfam13191
329726019382	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019383	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726019384	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019385	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726019386	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019387	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726019388	AAA ATPase domain; Region: AAA_16; pfam13191
329726019389	NACHT domain; Region: NACHT; pfam05729
329726019390	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726019391	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019392	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726019393	structural tetrad; other site
329726019394	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726019395	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726019396	structural tetrad; other site
329726019397	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
329726019398	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
329726019399	Family description; Region: VCBS; pfam13517
329726019400	Family description; Region: VCBS; pfam13517
329726019401	Family description; Region: VCBS; pfam13517
329726019402	Family description; Region: VCBS; pfam13517
329726019403	Family description; Region: VCBS; pfam13517
329726019404	Family description; Region: VCBS; pfam13517
329726019405	Calx-beta domain; Region: Calx-beta; cl02522
329726019406	Family description; Region: VCBS; pfam13517
329726019407	Family description; Region: VCBS; pfam13517
329726019408	Family description; Region: VCBS; pfam13517
329726019409	Family description; Region: VCBS; pfam13517
329726019410	Family description; Region: VCBS; pfam13517
329726019411	Family description; Region: VCBS; pfam13517
329726019412	Family description; Region: VCBS; pfam13517
329726019413	Family description; Region: VCBS; pfam13517
329726019414	Integrase core domain; Region: rve; pfam00665
329726019415	transposase; Validated; Region: PRK08181
329726019416	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726019417	Walker A motif; other site
329726019418	ATP binding site [chemical binding]; other site
329726019419	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
329726019420	Transposase; Region: DDE_Tnp_ISL3; pfam01610
329726019421	TrwC relaxase; Region: TrwC; pfam08751
329726019422	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
329726019423	AAA domain; Region: AAA_30; pfam13604
329726019424	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
329726019425	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726019426	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019427	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019428	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
329726019429	nucleotide binding site [chemical binding]; other site
329726019430	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region; Region: zf-PARP; pfam00645
329726019431	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
329726019432	Coenzyme A binding pocket [chemical binding]; other site
329726019433	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019434	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019435	binding surface
329726019436	TPR motif; other site
329726019437	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019438	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019439	binding surface
329726019440	TPR motif; other site
329726019441	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019442	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019443	TPR motif; other site
329726019444	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019445	binding surface
329726019446	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019447	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019448	binding surface
329726019449	TPR motif; other site
329726019450	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019451	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019452	TPR motif; other site
329726019453	binding surface
329726019454	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019455	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019456	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019457	binding surface
329726019458	TPR motif; other site
329726019459	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019460	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
329726019461	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
329726019462	catalytic residues [active]
329726019463	catalytic nucleophile [active]
329726019464	Presynaptic Site I dimer interface [polypeptide binding]; other site
329726019465	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
329726019466	Synaptic Flat tetramer interface [polypeptide binding]; other site
329726019467	Synaptic Site I dimer interface [polypeptide binding]; other site
329726019468	AAA domain; Region: AAA_13; pfam13166
329726019469	Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582
329726019470	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
329726019471	non-specific DNA binding site [nucleotide binding]; other site
329726019472	salt bridge; other site
329726019473	sequence-specific DNA binding site [nucleotide binding]; other site
329726019474	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
329726019475	Active Sites [active]
329726019476	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
329726019477	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
329726019478	active site
329726019479	Cation efflux family; Region: Cation_efflux; cl00316
329726019480	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
329726019481	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
329726019482	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
329726019483	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
329726019484	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
329726019485	metal binding site [ion binding]; metal-binding site
329726019486	active site
329726019487	I-site; other site
329726019488	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
329726019489	active site
329726019490	Int/Topo IB signature motif; other site
329726019491	DNA binding site [nucleotide binding]
329726019492	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726019493	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726019494	structural tetrad; other site
329726019495	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
329726019496	active site
329726019497	NB-ARC domain; Region: NB-ARC; pfam00931
329726019498	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019499	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019500	binding surface
329726019501	TPR motif; other site
329726019502	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019503	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019504	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019505	binding surface
329726019506	TPR motif; other site
329726019507	Tetratricopeptide repeat; Region: TPR_12; pfam13424
329726019508	CHAT domain; Region: CHAT; cl17868
329726019509	TIR domain; Region: TIR_2; pfam13676
329726019510	CHAT domain; Region: CHAT; cl17868
329726019511	NB-ARC domain; Region: NB-ARC; pfam00931
329726019512	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726019513	structural tetrad; other site
329726019514	FOG: WD40 repeat [General function prediction only]; Region: COG2319
329726019515	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
329726019516	structural tetrad; other site
329726019517	Caspase domain; Region: Peptidase_C14; pfam00656
329726019518	ski2-like helicase; Provisional; Region: PRK01172
329726019519	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
329726019520	ATP binding site [chemical binding]; other site
329726019521	putative Mg++ binding site [ion binding]; other site
329726019522	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
329726019523	nucleotide binding region [chemical binding]; other site
329726019524	ATP-binding site [chemical binding]; other site
329726019525	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
329726019526	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726019527	P-loop; other site
329726019528	Magnesium ion binding site [ion binding]; other site
329726019529	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
329726019530	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726019531	P-loop; other site
329726019532	Magnesium ion binding site [ion binding]; other site
329726019533	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
329726019534	Magnesium ion binding site [ion binding]; other site
329726019535	Integrase core domain; Region: rve; pfam00665
329726019536	transposase; Validated; Region: PRK08181
329726019537	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
329726019538	Walker A motif; other site
329726019539	ATP binding site [chemical binding]; other site
329726019540	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726019541	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019542	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019543	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
329726019544	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019545	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019546	NACHT domain; Region: NACHT; pfam05729
329726019547	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726019548	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019549	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019550	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019551	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019552	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019553	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726019554	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019555	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019556	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
329726019557	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
329726019558	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726019559	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019560	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019561	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
329726019562	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
329726019563	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
329726019564	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
329726019565	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
329726019566	DNA binding residues [nucleotide binding]
329726019567	AAA-like domain; Region: AAA_10; pfam12846
329726019568	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
329726019569	nucleophilic elbow; other site
329726019570	catalytic triad; other site
329726019571	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
329726019572	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
329726019573	Peptidase family M23; Region: Peptidase_M23; pfam01551
329726019574	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
329726019575	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
329726019576	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
329726019577	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
329726019578	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
329726019579	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
329726019580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
329726019581	binding surface
329726019582	TPR repeat; Region: TPR_11; pfam13414
329726019583	TPR motif; other site
329726019584	Methyltransferase domain; Region: Methyltransf_24; pfam13578
329726019585	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
329726019586	putative binding site; other site
329726019587	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
329726019588	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677