-- dump date   	20140618_183937
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
634457000001	Conjugal transfer protein TraD; Region: TraD; pfam06412
634457000002	MobA/MobL family; Region: MobA_MobL; pfam03389
634457000003	Helix-turn-helix domain; Region: HTH_36; pfam13730
634457000004	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
634457000005	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
634457000006	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
634457000007	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634457000008	active site
634457000009	Int/Topo IB signature motif; other site
634457000010	hypothetical protein; Validated; Region: PRK00124
634457000011	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
634457000012	dimer interface [polypeptide binding]; other site
634457000013	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
634457000014	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457000015	putative substrate translocation pore; other site
634457000016	Uncharacterized conserved protein [Function unknown]; Region: COG2835
634457000017	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
634457000018	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
634457000019	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634457000020	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
634457000021	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
634457000022	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
634457000023	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
634457000024	Creatinine amidohydrolase; Region: Creatininase; pfam02633
634457000025	Uncharacterized conserved protein [Function unknown]; Region: COG3391
634457000026	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
634457000027	AAA ATPase domain; Region: AAA_16; pfam13191
634457000028	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
634457000029	Uncharacterized conserved protein [Function unknown]; Region: COG3410
634457000030	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
634457000031	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
634457000032	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
634457000033	putative FMN binding site [chemical binding]; other site
634457000034	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
634457000035	Glycoprotease family; Region: Peptidase_M22; pfam00814
634457000036	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634457000037	Coenzyme A binding pocket [chemical binding]; other site
634457000038	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
634457000039	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
634457000040	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
634457000041	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
634457000042	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
634457000043	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
634457000044	generic binding surface II; other site
634457000045	generic binding surface I; other site
634457000046	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
634457000047	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634457000048	catalytic residue [active]
634457000049	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634457000050	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634457000051	NAD(P) binding site [chemical binding]; other site
634457000052	catalytic residues [active]
634457000053	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
634457000054	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
634457000055	NAD binding site [chemical binding]; other site
634457000056	substrate binding site [chemical binding]; other site
634457000057	catalytic Zn binding site [ion binding]; other site
634457000058	tetramer interface [polypeptide binding]; other site
634457000059	structural Zn binding site [ion binding]; other site
634457000060	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
634457000061	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
634457000062	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
634457000063	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
634457000064	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
634457000065	ligand binding site [chemical binding]; other site
634457000066	homodimer interface [polypeptide binding]; other site
634457000067	NAD(P) binding site [chemical binding]; other site
634457000068	trimer interface B [polypeptide binding]; other site
634457000069	trimer interface A [polypeptide binding]; other site
634457000070	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
634457000071	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
634457000072	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
634457000073	Iron-sulfur protein interface; other site
634457000074	proximal quinone binding site [chemical binding]; other site
634457000075	SdhD (CybS) interface [polypeptide binding]; other site
634457000076	proximal heme binding site [chemical binding]; other site
634457000077	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
634457000078	putative SdhC subunit interface [polypeptide binding]; other site
634457000079	putative proximal heme binding site [chemical binding]; other site
634457000080	putative Iron-sulfur protein interface [polypeptide binding]; other site
634457000081	putative proximal quinone binding site; other site
634457000082	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
634457000083	L-aspartate oxidase; Provisional; Region: PRK06175
634457000084	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
634457000085	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
634457000086	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
634457000087	Putative phosphatase (DUF442); Region: DUF442; cl17385
634457000088	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634457000089	EamA-like transporter family; Region: EamA; pfam00892
634457000090	Phosphoglycerate kinase; Region: PGK; pfam00162
634457000091	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
634457000092	substrate binding site [chemical binding]; other site
634457000093	hinge regions; other site
634457000094	ADP binding site [chemical binding]; other site
634457000095	catalytic site [active]
634457000096	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
634457000097	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
634457000098	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
634457000099	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
634457000100	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
634457000101	TPP-binding site [chemical binding]; other site
634457000102	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634457000103	PYR/PP interface [polypeptide binding]; other site
634457000104	dimer interface [polypeptide binding]; other site
634457000105	TPP binding site [chemical binding]; other site
634457000106	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634457000107	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
634457000108	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
634457000109	substrate-cofactor binding pocket; other site
634457000110	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457000111	catalytic residue [active]
634457000112	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
634457000113	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
634457000114	catalytic residues [active]
634457000115	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
634457000116	recombinase A; Provisional; Region: recA; PRK09354
634457000117	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
634457000118	hexamer interface [polypeptide binding]; other site
634457000119	Walker A motif; other site
634457000120	ATP binding site [chemical binding]; other site
634457000121	Walker B motif; other site
634457000122	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
634457000123	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634457000124	Coenzyme A binding pocket [chemical binding]; other site
634457000125	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
634457000126	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
634457000127	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
634457000128	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
634457000129	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
634457000130	Ligand binding site; other site
634457000131	DXD motif; other site
634457000132	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
634457000133	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
634457000134	active site
634457000135	dimer interface [polypeptide binding]; other site
634457000136	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
634457000137	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457000138	putative substrate translocation pore; other site
634457000139	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
634457000140	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457000141	Walker A motif; other site
634457000142	ATP binding site [chemical binding]; other site
634457000143	Walker B motif; other site
634457000144	arginine finger; other site
634457000145	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
634457000146	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
634457000147	hypothetical protein; Validated; Region: PRK00153
634457000148	recombination protein RecR; Reviewed; Region: recR; PRK00076
634457000149	RecR protein; Region: RecR; pfam02132
634457000150	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
634457000151	putative active site [active]
634457000152	putative metal-binding site [ion binding]; other site
634457000153	tetramer interface [polypeptide binding]; other site
634457000154	short chain dehydrogenase; Provisional; Region: PRK09134
634457000155	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457000156	NAD(P) binding site [chemical binding]; other site
634457000157	active site
634457000158	Dihydroneopterin aldolase; Region: FolB; pfam02152
634457000159	active site
634457000160	TIGR02300 family protein; Region: FYDLN_acid
634457000161	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
634457000162	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
634457000163	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
634457000164	hinge; other site
634457000165	active site
634457000166	cytidylate kinase; Provisional; Region: cmk; PRK00023
634457000167	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
634457000168	CMP-binding site; other site
634457000169	The sites determining sugar specificity; other site
634457000170	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
634457000171	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
634457000172	RNA binding site [nucleotide binding]; other site
634457000173	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
634457000174	RNA binding site [nucleotide binding]; other site
634457000175	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
634457000176	RNA binding site [nucleotide binding]; other site
634457000177	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
634457000178	RNA binding site [nucleotide binding]; other site
634457000179	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
634457000180	RNA binding site [nucleotide binding]; other site
634457000181	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
634457000182	RNA binding site [nucleotide binding]; other site
634457000183	Major royal jelly protein; Region: MRJP; pfam03022
634457000184	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
634457000185	active site
634457000186	dimerization interface [polypeptide binding]; other site
634457000187	ribonuclease PH; Reviewed; Region: rph; PRK00173
634457000188	Ribonuclease PH; Region: RNase_PH_bact; cd11362
634457000189	hexamer interface [polypeptide binding]; other site
634457000190	active site
634457000191	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
634457000192	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
634457000193	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
634457000194	Transglycosylase; Region: Transgly; pfam00912
634457000195	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
634457000196	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
634457000197	This domain is found in peptide chain release factors; Region: PCRF; smart00937
634457000198	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
634457000199	RF-1 domain; Region: RF-1; pfam00472
634457000200	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634457000201	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
634457000202	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634457000203	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634457000204	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634457000205	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634457000206	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
634457000207	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
634457000208	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
634457000209	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
634457000210	rod shape-determining protein MreC; Provisional; Region: PRK13922
634457000211	rod shape-determining protein MreC; Region: MreC; pfam04085
634457000212	rod shape-determining protein MreB; Provisional; Region: PRK13927
634457000213	MreB and similar proteins; Region: MreB_like; cd10225
634457000214	nucleotide binding site [chemical binding]; other site
634457000215	Mg binding site [ion binding]; other site
634457000216	putative protofilament interaction site [polypeptide binding]; other site
634457000217	RodZ interaction site [polypeptide binding]; other site
634457000218	2-isopropylmalate synthase; Validated; Region: PRK00915
634457000219	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
634457000220	active site
634457000221	catalytic residues [active]
634457000222	metal binding site [ion binding]; metal-binding site
634457000223	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
634457000224	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
634457000225	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
634457000226	Uncharacterized conserved protein [Function unknown]; Region: COG0398
634457000227	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
634457000228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457000229	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
634457000230	putative substrate translocation pore; other site
634457000231	PAS fold; Region: PAS_7; pfam12860
634457000232	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634457000233	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634457000234	dimer interface [polypeptide binding]; other site
634457000235	phosphorylation site [posttranslational modification]
634457000236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457000237	ATP binding site [chemical binding]; other site
634457000238	Mg2+ binding site [ion binding]; other site
634457000239	G-X-G motif; other site
634457000240	Response regulator receiver domain; Region: Response_reg; pfam00072
634457000241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457000242	active site
634457000243	phosphorylation site [posttranslational modification]
634457000244	intermolecular recognition site; other site
634457000245	dimerization interface [polypeptide binding]; other site
634457000246	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634457000247	active site
634457000248	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634457000249	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634457000250	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
634457000251	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
634457000252	MOFRL family; Region: MOFRL; pfam05161
634457000253	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
634457000254	ligand binding site [chemical binding]; other site
634457000255	active site
634457000256	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634457000257	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634457000258	Cytochrome c; Region: Cytochrom_C; pfam00034
634457000259	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
634457000260	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
634457000261	Trp docking motif [polypeptide binding]; other site
634457000262	cytochrome domain interface [polypeptide binding]; other site
634457000263	active site
634457000264	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634457000265	Cytochrome c; Region: Cytochrom_C; pfam00034
634457000266	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
634457000267	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
634457000268	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
634457000269	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
634457000270	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
634457000271	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
634457000272	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
634457000273	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
634457000274	D-pathway; other site
634457000275	Putative ubiquinol binding site [chemical binding]; other site
634457000276	Low-spin heme (heme b) binding site [chemical binding]; other site
634457000277	Putative water exit pathway; other site
634457000278	Binuclear center (heme o3/CuB) [ion binding]; other site
634457000279	K-pathway; other site
634457000280	Putative proton exit pathway; other site
634457000281	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
634457000282	Subunit I/III interface [polypeptide binding]; other site
634457000283	Subunit III/IV interface [polypeptide binding]; other site
634457000284	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
634457000285	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
634457000286	4Fe-4S binding domain; Region: Fer4; pfam00037
634457000287	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
634457000288	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
634457000289	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634457000290	nucleotide binding region [chemical binding]; other site
634457000291	ATP-binding site [chemical binding]; other site
634457000292	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
634457000293	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
634457000294	interface (dimer of trimers) [polypeptide binding]; other site
634457000295	Substrate-binding/catalytic site; other site
634457000296	Zn-binding sites [ion binding]; other site
634457000297	MarR family; Region: MarR; pfam01047
634457000298	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
634457000299	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
634457000300	Mg++ binding site [ion binding]; other site
634457000301	putative catalytic motif [active]
634457000302	putative substrate binding site [chemical binding]; other site
634457000303	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
634457000304	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
634457000305	NAD(P) binding site [chemical binding]; other site
634457000306	homodimer interface [polypeptide binding]; other site
634457000307	substrate binding site [chemical binding]; other site
634457000308	active site
634457000309	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
634457000310	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
634457000311	inhibitor-cofactor binding pocket; inhibition site
634457000312	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457000313	catalytic residue [active]
634457000314	dihydroorotase; Validated; Region: PRK09060
634457000315	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634457000316	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
634457000317	active site
634457000318	glutathione reductase; Validated; Region: PRK06116
634457000319	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634457000320	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634457000321	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
634457000322	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
634457000323	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
634457000324	FAD binding pocket [chemical binding]; other site
634457000325	FAD binding motif [chemical binding]; other site
634457000326	phosphate binding motif [ion binding]; other site
634457000327	beta-alpha-beta structure motif; other site
634457000328	NAD binding pocket [chemical binding]; other site
634457000329	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634457000330	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634457000331	ATP binding site [chemical binding]; other site
634457000332	putative Mg++ binding site [ion binding]; other site
634457000333	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
634457000334	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634457000335	nucleotide binding region [chemical binding]; other site
634457000336	ATP-binding site [chemical binding]; other site
634457000337	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
634457000338	short chain dehydrogenase; Provisional; Region: PRK06197
634457000339	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457000340	NAD(P) binding site [chemical binding]; other site
634457000341	active site
634457000342	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
634457000343	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
634457000344	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
634457000345	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
634457000346	malate dehydrogenase; Provisional; Region: PRK13529
634457000347	Malic enzyme, N-terminal domain; Region: malic; pfam00390
634457000348	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
634457000349	NAD(P) binding site [chemical binding]; other site
634457000350	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
634457000351	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
634457000352	putative homodimer interface [polypeptide binding]; other site
634457000353	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
634457000354	heterodimer interface [polypeptide binding]; other site
634457000355	homodimer interface [polypeptide binding]; other site
634457000356	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
634457000357	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
634457000358	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
634457000359	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
634457000360	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
634457000361	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
634457000362	beta subunit interaction interface [polypeptide binding]; other site
634457000363	Walker A motif; other site
634457000364	ATP binding site [chemical binding]; other site
634457000365	Walker B motif; other site
634457000366	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
634457000367	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
634457000368	core domain interface [polypeptide binding]; other site
634457000369	delta subunit interface [polypeptide binding]; other site
634457000370	epsilon subunit interface [polypeptide binding]; other site
634457000371	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
634457000372	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
634457000373	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
634457000374	alpha subunit interaction interface [polypeptide binding]; other site
634457000375	Walker A motif; other site
634457000376	ATP binding site [chemical binding]; other site
634457000377	Walker B motif; other site
634457000378	inhibitor binding site; inhibition site
634457000379	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
634457000380	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
634457000381	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
634457000382	gamma subunit interface [polypeptide binding]; other site
634457000383	epsilon subunit interface [polypeptide binding]; other site
634457000384	LBP interface [polypeptide binding]; other site
634457000385	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
634457000386	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
634457000387	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
634457000388	catalytic site [active]
634457000389	putative active site [active]
634457000390	putative substrate binding site [chemical binding]; other site
634457000391	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
634457000392	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
634457000393	substrate binding site [chemical binding]; other site
634457000394	ATP binding site [chemical binding]; other site
634457000395	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
634457000396	GcrA cell cycle regulator; Region: GcrA; cl11564
634457000397	GcrA cell cycle regulator; Region: GcrA; cl11564
634457000398	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
634457000399	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
634457000400	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457000401	Walker A/P-loop; other site
634457000402	ATP binding site [chemical binding]; other site
634457000403	Q-loop/lid; other site
634457000404	ABC transporter signature motif; other site
634457000405	Walker B; other site
634457000406	D-loop; other site
634457000407	H-loop/switch region; other site
634457000408	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
634457000409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457000410	dimer interface [polypeptide binding]; other site
634457000411	conserved gate region; other site
634457000412	putative PBP binding loops; other site
634457000413	ABC-ATPase subunit interface; other site
634457000414	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
634457000415	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457000416	dimer interface [polypeptide binding]; other site
634457000417	conserved gate region; other site
634457000418	putative PBP binding loops; other site
634457000419	ABC-ATPase subunit interface; other site
634457000420	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457000421	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
634457000422	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
634457000423	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
634457000424	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
634457000425	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
634457000426	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634457000427	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
634457000428	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
634457000429	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
634457000430	ethanolamine permease; Region: 2A0305; TIGR00908
634457000431	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
634457000432	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634457000433	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457000434	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
634457000435	Protein export membrane protein; Region: SecD_SecF; cl14618
634457000436	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634457000437	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634457000438	DNA-binding site [nucleotide binding]; DNA binding site
634457000439	RNA-binding motif; other site
634457000440	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457000441	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457000442	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457000443	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634457000444	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634457000445	N-terminal plug; other site
634457000446	ligand-binding site [chemical binding]; other site
634457000447	hypothetical protein; Provisional; Region: PRK09945
634457000448	Hint domain; Region: Hint_2; pfam13403
634457000449	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634457000450	formamidase; Provisional; Region: amiF; PRK13287
634457000451	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
634457000452	multimer interface [polypeptide binding]; other site
634457000453	active site
634457000454	catalytic triad [active]
634457000455	dimer interface [polypeptide binding]; other site
634457000456	Response regulator receiver domain; Region: Response_reg; pfam00072
634457000457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457000458	active site
634457000459	phosphorylation site [posttranslational modification]
634457000460	intermolecular recognition site; other site
634457000461	dimerization interface [polypeptide binding]; other site
634457000462	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
634457000463	DNA binding residues [nucleotide binding]
634457000464	dimerization interface [polypeptide binding]; other site
634457000465	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634457000466	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634457000467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634457000468	dimer interface [polypeptide binding]; other site
634457000469	phosphorylation site [posttranslational modification]
634457000470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457000471	ATP binding site [chemical binding]; other site
634457000472	Mg2+ binding site [ion binding]; other site
634457000473	G-X-G motif; other site
634457000474	Response regulator receiver domain; Region: Response_reg; pfam00072
634457000475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457000476	active site
634457000477	phosphorylation site [posttranslational modification]
634457000478	intermolecular recognition site; other site
634457000479	dimerization interface [polypeptide binding]; other site
634457000480	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
634457000481	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
634457000482	putative ligand binding site [chemical binding]; other site
634457000483	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
634457000484	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
634457000485	TM-ABC transporter signature motif; other site
634457000486	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
634457000487	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
634457000488	TM-ABC transporter signature motif; other site
634457000489	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
634457000490	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
634457000491	Walker A/P-loop; other site
634457000492	ATP binding site [chemical binding]; other site
634457000493	Q-loop/lid; other site
634457000494	ABC transporter signature motif; other site
634457000495	Walker B; other site
634457000496	D-loop; other site
634457000497	H-loop/switch region; other site
634457000498	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
634457000499	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
634457000500	Walker A/P-loop; other site
634457000501	ATP binding site [chemical binding]; other site
634457000502	Q-loop/lid; other site
634457000503	ABC transporter signature motif; other site
634457000504	Walker B; other site
634457000505	D-loop; other site
634457000506	H-loop/switch region; other site
634457000507	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457000508	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
634457000509	Predicted transcriptional regulator [Transcription]; Region: COG2378
634457000510	WYL domain; Region: WYL; pfam13280
634457000511	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457000512	active site
634457000513	Int/Topo IB signature motif; other site
634457000514	DNA binding site [nucleotide binding]
634457000515	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457000516	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
634457000517	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457000518	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
634457000519	active site
634457000520	Catalytic domain of Protein Kinases; Region: PKc; cd00180
634457000521	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
634457000522	active site
634457000523	ATP binding site [chemical binding]; other site
634457000524	substrate binding site [chemical binding]; other site
634457000525	activation loop (A-loop); other site
634457000526	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
634457000527	Catalytic domain of Protein Kinases; Region: PKc; cd00180
634457000528	active site
634457000529	ATP binding site [chemical binding]; other site
634457000530	substrate binding site [chemical binding]; other site
634457000531	activation loop (A-loop); other site
634457000532	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457000533	active site
634457000534	Int/Topo IB signature motif; other site
634457000535	DNA binding site [nucleotide binding]
634457000536	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634457000537	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634457000538	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634457000539	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634457000540	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634457000541	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634457000542	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634457000543	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634457000544	Transposase; Region: HTH_Tnp_1; pfam01527
634457000545	Protein of unknown function DUF45; Region: DUF45; pfam01863
634457000546	hypothetical protein; Provisional; Region: PRK05170
634457000547	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
634457000548	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
634457000549	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457000550	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
634457000551	Walker A/P-loop; other site
634457000552	ATP binding site [chemical binding]; other site
634457000553	Q-loop/lid; other site
634457000554	ABC transporter signature motif; other site
634457000555	Walker B; other site
634457000556	D-loop; other site
634457000557	H-loop/switch region; other site
634457000558	TOBE domain; Region: TOBE_2; pfam08402
634457000559	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
634457000560	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
634457000561	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
634457000562	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
634457000563	multidrug resistance protein MdtN; Provisional; Region: PRK10476
634457000564	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634457000565	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457000566	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634457000567	hopanoid-associated phosphorylase; Region: HpnG; TIGR03468
634457000568	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
634457000569	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
634457000570	Active site cavity [active]
634457000571	catalytic acid [active]
634457000572	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
634457000573	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
634457000574	active site lid residues [active]
634457000575	substrate binding pocket [chemical binding]; other site
634457000576	catalytic residues [active]
634457000577	substrate-Mg2+ binding site; other site
634457000578	aspartate-rich region 1; other site
634457000579	aspartate-rich region 2; other site
634457000580	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
634457000581	active site lid residues [active]
634457000582	substrate binding pocket [chemical binding]; other site
634457000583	catalytic residues [active]
634457000584	substrate-Mg2+ binding site; other site
634457000585	aspartate-rich region 1; other site
634457000586	aspartate-rich region 2; other site
634457000587	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
634457000588	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634457000589	active site
634457000590	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634457000591	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
634457000592	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
634457000593	putative NADP binding site [chemical binding]; other site
634457000594	putative substrate binding site [chemical binding]; other site
634457000595	active site
634457000596	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
634457000597	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
634457000598	prephenate dehydrogenase; Validated; Region: PRK08507
634457000599	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634457000600	TPR motif; other site
634457000601	TPR repeat; Region: TPR_11; pfam13414
634457000602	binding surface
634457000603	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457000604	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457000605	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
634457000606	dimerization interface [polypeptide binding]; other site
634457000607	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
634457000608	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
634457000609	dimer interface [polypeptide binding]; other site
634457000610	decamer (pentamer of dimers) interface [polypeptide binding]; other site
634457000611	catalytic triad [active]
634457000612	peroxidatic and resolving cysteines [active]
634457000613	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
634457000614	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
634457000615	Uncharacterized conserved protein [Function unknown]; Region: COG2353
634457000616	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
634457000617	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
634457000618	putative active site [active]
634457000619	metal binding site [ion binding]; metal-binding site
634457000620	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
634457000621	dimer interface [polypeptide binding]; other site
634457000622	substrate binding site [chemical binding]; other site
634457000623	metal binding sites [ion binding]; metal-binding site
634457000624	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
634457000625	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457000626	Walker A/P-loop; other site
634457000627	ATP binding site [chemical binding]; other site
634457000628	Q-loop/lid; other site
634457000629	ABC transporter signature motif; other site
634457000630	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634457000631	ABC transporter; Region: ABC_tran_2; pfam12848
634457000632	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634457000633	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
634457000634	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
634457000635	Coenzyme A binding pocket [chemical binding]; other site
634457000636	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
634457000637	VacJ like lipoprotein; Region: VacJ; cl01073
634457000638	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
634457000639	putative metal binding site [ion binding]; other site
634457000640	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
634457000641	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634457000642	HSP70 interaction site [polypeptide binding]; other site
634457000643	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
634457000644	epoxyqueuosine reductase; Region: TIGR00276
634457000645	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
634457000646	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
634457000647	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
634457000648	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
634457000649	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
634457000650	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
634457000651	substrate binding site [chemical binding]; other site
634457000652	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
634457000653	FAD binding site [chemical binding]; other site
634457000654	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
634457000655	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
634457000656	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
634457000657	homodimer interface [polypeptide binding]; other site
634457000658	NADP binding site [chemical binding]; other site
634457000659	substrate binding site [chemical binding]; other site
634457000660	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
634457000661	Protein of unknown function, DUF482; Region: DUF482; pfam04339
634457000662	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
634457000663	homotrimer interaction site [polypeptide binding]; other site
634457000664	putative active site [active]
634457000665	TSCPD domain; Region: TSCPD; pfam12637
634457000666	NADH dehydrogenase; Validated; Region: PRK08183
634457000667	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
634457000668	mce related protein; Region: MCE; pfam02470
634457000669	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
634457000670	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634457000671	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
634457000672	active site
634457000673	motif I; other site
634457000674	motif II; other site
634457000675	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
634457000676	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
634457000677	active site
634457000678	homotetramer interface [polypeptide binding]; other site
634457000679	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
634457000680	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634457000681	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
634457000682	Probable Catalytic site; other site
634457000683	metal-binding site
634457000684	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457000685	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
634457000686	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
634457000687	nudix motif; other site
634457000688	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634457000689	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
634457000690	active site
634457000691	catalytic tetrad [active]
634457000692	Helix-turn-helix domain; Region: HTH_17; pfam12728
634457000693	excinuclease ABC subunit B; Provisional; Region: PRK05298
634457000694	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634457000695	ATP binding site [chemical binding]; other site
634457000696	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634457000697	nucleotide binding region [chemical binding]; other site
634457000698	ATP-binding site [chemical binding]; other site
634457000699	Ultra-violet resistance protein B; Region: UvrB; pfam12344
634457000700	UvrB/uvrC motif; Region: UVR; pfam02151
634457000701	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
634457000702	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
634457000703	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
634457000704	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
634457000705	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
634457000706	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
634457000707	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
634457000708	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634457000709	active site
634457000710	motif I; other site
634457000711	motif II; other site
634457000712	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634457000713	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
634457000714	active site
634457000715	L-asparagine permease; Provisional; Region: PRK15049
634457000716	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
634457000717	active site
634457000718	DNA polymerase IV; Validated; Region: PRK02406
634457000719	DNA binding site [nucleotide binding]
634457000720	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
634457000721	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
634457000722	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
634457000723	quinone interaction residues [chemical binding]; other site
634457000724	active site
634457000725	catalytic residues [active]
634457000726	FMN binding site [chemical binding]; other site
634457000727	substrate binding site [chemical binding]; other site
634457000728	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
634457000729	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634457000730	active site
634457000731	motif I; other site
634457000732	motif II; other site
634457000733	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634457000734	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
634457000735	nudix motif; other site
634457000736	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
634457000737	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
634457000738	putative active site [active]
634457000739	metal binding site [ion binding]; metal-binding site
634457000740	homodimer binding site [polypeptide binding]; other site
634457000741	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
634457000742	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
634457000743	Cell division protein ZapA; Region: ZapA; cl01146
634457000744	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
634457000745	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
634457000746	putative active site; other site
634457000747	catalytic residue [active]
634457000748	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
634457000749	thiamine phosphate binding site [chemical binding]; other site
634457000750	active site
634457000751	pyrophosphate binding site [ion binding]; other site
634457000752	Prophage antirepressor [Transcription]; Region: COG3617
634457000753	BRO family, N-terminal domain; Region: Bro-N; smart01040
634457000754	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
634457000755	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
634457000756	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
634457000757	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457000758	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
634457000759	Transposase; Region: DDE_Tnp_ISL3; pfam01610
634457000760	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457000761	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457000762	Transposase; Region: DDE_Tnp_ISL3; pfam01610
634457000763	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
634457000764	Fasciclin domain; Region: Fasciclin; cl02663
634457000765	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
634457000766	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
634457000767	motif 1; other site
634457000768	dimer interface [polypeptide binding]; other site
634457000769	active site
634457000770	motif 2; other site
634457000771	motif 3; other site
634457000772	Radical SAM superfamily; Region: Radical_SAM; pfam04055
634457000773	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457000774	FeS/SAM binding site; other site
634457000775	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
634457000776	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
634457000777	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
634457000778	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
634457000779	active site
634457000780	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
634457000781	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
634457000782	Uncharacterized conserved protein [Function unknown]; Region: COG2127
634457000783	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
634457000784	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457000785	Walker A motif; other site
634457000786	ATP binding site [chemical binding]; other site
634457000787	Walker B motif; other site
634457000788	arginine finger; other site
634457000789	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457000790	Walker A motif; other site
634457000791	ATP binding site [chemical binding]; other site
634457000792	Walker B motif; other site
634457000793	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
634457000794	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
634457000795	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
634457000796	Putative transcriptional regulator [Transcription]; Region: COG1678
634457000797	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
634457000798	Shikimate kinase; Region: SKI; pfam01202
634457000799	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
634457000800	homotrimer interaction site [polypeptide binding]; other site
634457000801	putative active site [active]
634457000802	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
634457000803	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
634457000804	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634457000805	HAMP domain; Region: HAMP; pfam00672
634457000806	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634457000807	dimer interface [polypeptide binding]; other site
634457000808	phosphorylation site [posttranslational modification]
634457000809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457000810	ATP binding site [chemical binding]; other site
634457000811	Mg2+ binding site [ion binding]; other site
634457000812	G-X-G motif; other site
634457000813	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634457000814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457000815	active site
634457000816	phosphorylation site [posttranslational modification]
634457000817	intermolecular recognition site; other site
634457000818	dimerization interface [polypeptide binding]; other site
634457000819	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634457000820	DNA binding site [nucleotide binding]
634457000821	GrpE; Region: GrpE; pfam01025
634457000822	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
634457000823	dimer interface [polypeptide binding]; other site
634457000824	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
634457000825	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
634457000826	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
634457000827	nucleotide binding site [chemical binding]; other site
634457000828	NEF interaction site [polypeptide binding]; other site
634457000829	SBD interface [polypeptide binding]; other site
634457000830	chaperone protein DnaJ; Provisional; Region: PRK10767
634457000831	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634457000832	HSP70 interaction site [polypeptide binding]; other site
634457000833	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
634457000834	Zn binding sites [ion binding]; other site
634457000835	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
634457000836	dimer interface [polypeptide binding]; other site
634457000837	dihydrodipicolinate reductase; Provisional; Region: PRK00048
634457000838	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
634457000839	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
634457000840	S-adenosylmethionine synthetase; Validated; Region: PRK05250
634457000841	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
634457000842	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
634457000843	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
634457000844	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
634457000845	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
634457000846	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
634457000847	purine monophosphate binding site [chemical binding]; other site
634457000848	dimer interface [polypeptide binding]; other site
634457000849	putative catalytic residues [active]
634457000850	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
634457000851	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634457000852	EamA-like transporter family; Region: EamA; pfam00892
634457000853	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
634457000854	DALR anticodon binding domain; Region: DALR_1; pfam05746
634457000855	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
634457000856	dimer interface [polypeptide binding]; other site
634457000857	motif 1; other site
634457000858	active site
634457000859	motif 2; other site
634457000860	motif 3; other site
634457000861	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
634457000862	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634457000863	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634457000864	non-specific DNA binding site [nucleotide binding]; other site
634457000865	salt bridge; other site
634457000866	sequence-specific DNA binding site [nucleotide binding]; other site
634457000867	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
634457000868	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
634457000869	putative active site [active]
634457000870	catalytic triad [active]
634457000871	putative dimer interface [polypeptide binding]; other site
634457000872	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
634457000873	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
634457000874	metal binding site 2 [ion binding]; metal-binding site
634457000875	putative DNA binding helix; other site
634457000876	metal binding site 1 [ion binding]; metal-binding site
634457000877	dimer interface [polypeptide binding]; other site
634457000878	structural Zn2+ binding site [ion binding]; other site
634457000879	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
634457000880	CPxP  motif; other site
634457000881	transcription termination factor Rho; Provisional; Region: rho; PRK09376
634457000882	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
634457000883	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
634457000884	RNA binding site [nucleotide binding]; other site
634457000885	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
634457000886	multimer interface [polypeptide binding]; other site
634457000887	Walker A motif; other site
634457000888	ATP binding site [chemical binding]; other site
634457000889	Walker B motif; other site
634457000890	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
634457000891	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
634457000892	oligomer interface [polypeptide binding]; other site
634457000893	Cl binding site [ion binding]; other site
634457000894	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
634457000895	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
634457000896	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457000897	catalytic residue [active]
634457000898	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
634457000899	substrate binding site [chemical binding]; other site
634457000900	active site
634457000901	catalytic residues [active]
634457000902	heterodimer interface [polypeptide binding]; other site
634457000903	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
634457000904	HerA helicase [Replication, recombination, and repair]; Region: COG0433
634457000905	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634457000906	Walker A motif; other site
634457000907	ATP binding site [chemical binding]; other site
634457000908	Walker B motif; other site
634457000909	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
634457000910	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
634457000911	dimer interface [polypeptide binding]; other site
634457000912	motif 1; other site
634457000913	active site
634457000914	motif 2; other site
634457000915	motif 3; other site
634457000916	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
634457000917	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
634457000918	GDP-binding site [chemical binding]; other site
634457000919	ACT binding site; other site
634457000920	IMP binding site; other site
634457000921	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
634457000922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457000923	active site
634457000924	phosphorylation site [posttranslational modification]
634457000925	intermolecular recognition site; other site
634457000926	dimerization interface [polypeptide binding]; other site
634457000927	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634457000928	DNA binding site [nucleotide binding]
634457000929	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
634457000930	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634457000931	dimer interface [polypeptide binding]; other site
634457000932	phosphorylation site [posttranslational modification]
634457000933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457000934	ATP binding site [chemical binding]; other site
634457000935	Mg2+ binding site [ion binding]; other site
634457000936	G-X-G motif; other site
634457000937	PBP superfamily domain; Region: PBP_like_2; cl17296
634457000938	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
634457000939	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
634457000940	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634457000941	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
634457000942	catalytic core [active]
634457000943	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
634457000944	Domain of unknown function DUF21; Region: DUF21; pfam01595
634457000945	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
634457000946	Transporter associated domain; Region: CorC_HlyC; smart01091
634457000947	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
634457000948	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
634457000949	NADP binding site [chemical binding]; other site
634457000950	dimer interface [polypeptide binding]; other site
634457000951	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
634457000952	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
634457000953	putative active site [active]
634457000954	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634457000955	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
634457000956	Walker A/P-loop; other site
634457000957	ATP binding site [chemical binding]; other site
634457000958	Q-loop/lid; other site
634457000959	ABC transporter signature motif; other site
634457000960	Walker B; other site
634457000961	D-loop; other site
634457000962	H-loop/switch region; other site
634457000963	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
634457000964	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634457000965	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457000966	Hint domain; Region: Hint_2; pfam13403
634457000967	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
634457000968	classical (c) SDRs; Region: SDR_c; cd05233
634457000969	NAD(P) binding site [chemical binding]; other site
634457000970	active site
634457000971	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
634457000972	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
634457000973	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
634457000974	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
634457000975	homodimer interface [polypeptide binding]; other site
634457000976	metal binding site [ion binding]; metal-binding site
634457000977	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
634457000978	homodimer interface [polypeptide binding]; other site
634457000979	active site
634457000980	putative chemical substrate binding site [chemical binding]; other site
634457000981	metal binding site [ion binding]; metal-binding site
634457000982	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
634457000983	heat shock protein 90; Provisional; Region: PRK05218
634457000984	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457000985	ATP binding site [chemical binding]; other site
634457000986	Mg2+ binding site [ion binding]; other site
634457000987	G-X-G motif; other site
634457000988	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
634457000989	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457000990	DNA binding site [nucleotide binding]
634457000991	active site
634457000992	Int/Topo IB signature motif; other site
634457000993	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
634457000994	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457000995	CotH protein; Region: CotH; pfam08757
634457000996	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
634457000997	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
634457000998	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
634457000999	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
634457001000	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
634457001001	active site
634457001002	substrate binding site [chemical binding]; other site
634457001003	Mg2+ binding site [ion binding]; other site
634457001004	hypothetical protein; Provisional; Region: PRK09272
634457001005	hypothetical protein; Provisional; Region: PRK10316
634457001006	YfdX protein; Region: YfdX; pfam10938
634457001007	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634457001008	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634457001009	sequence-specific DNA binding site [nucleotide binding]; other site
634457001010	salt bridge; other site
634457001011	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
634457001012	Domain of unknown function (DUF955); Region: DUF955; pfam06114
634457001013	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
634457001014	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
634457001015	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
634457001016	methylcitrate synthase; Provisional; Region: PRK12351
634457001017	oxalacetate binding site [chemical binding]; other site
634457001018	citrylCoA binding site [chemical binding]; other site
634457001019	coenzyme A binding site [chemical binding]; other site
634457001020	catalytic triad [active]
634457001021	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
634457001022	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
634457001023	tetramer interface [polypeptide binding]; other site
634457001024	active site
634457001025	Mg2+/Mn2+ binding site [ion binding]; other site
634457001026	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
634457001027	acetyl-CoA synthetase; Provisional; Region: PRK00174
634457001028	acyl-activating enzyme (AAE) consensus motif; other site
634457001029	AMP binding site [chemical binding]; other site
634457001030	active site
634457001031	CoA binding site [chemical binding]; other site
634457001032	putative sialic acid transporter; Region: 2A0112; TIGR00891
634457001033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457001034	putative substrate translocation pore; other site
634457001035	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
634457001036	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
634457001037	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
634457001038	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
634457001039	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
634457001040	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
634457001041	dimer interface [polypeptide binding]; other site
634457001042	anticodon binding site; other site
634457001043	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
634457001044	homodimer interface [polypeptide binding]; other site
634457001045	motif 1; other site
634457001046	active site
634457001047	motif 2; other site
634457001048	GAD domain; Region: GAD; pfam02938
634457001049	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
634457001050	active site
634457001051	motif 3; other site
634457001052	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
634457001053	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
634457001054	tetramer interface [polypeptide binding]; other site
634457001055	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457001056	catalytic residue [active]
634457001057	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
634457001058	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
634457001059	5S rRNA interface [nucleotide binding]; other site
634457001060	CTC domain interface [polypeptide binding]; other site
634457001061	L16 interface [polypeptide binding]; other site
634457001062	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
634457001063	putative active site [active]
634457001064	catalytic residue [active]
634457001065	GTP-binding protein YchF; Reviewed; Region: PRK09601
634457001066	YchF GTPase; Region: YchF; cd01900
634457001067	G1 box; other site
634457001068	GTP/Mg2+ binding site [chemical binding]; other site
634457001069	Switch I region; other site
634457001070	G2 box; other site
634457001071	Switch II region; other site
634457001072	G3 box; other site
634457001073	G4 box; other site
634457001074	G5 box; other site
634457001075	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
634457001076	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
634457001077	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
634457001078	putative catalytic cysteine [active]
634457001079	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
634457001080	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
634457001081	active site
634457001082	(T/H)XGH motif; other site
634457001083	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
634457001084	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
634457001085	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
634457001086	Rhodanese-like domain; Region: Rhodanese; pfam00581
634457001087	active site residue [active]
634457001088	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
634457001089	active site residue [active]
634457001090	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457001091	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457001092	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
634457001093	putative dimerization interface [polypeptide binding]; other site
634457001094	putative substrate binding pocket [chemical binding]; other site
634457001095	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
634457001096	acetolactate synthase; Reviewed; Region: PRK08617
634457001097	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634457001098	PYR/PP interface [polypeptide binding]; other site
634457001099	dimer interface [polypeptide binding]; other site
634457001100	TPP binding site [chemical binding]; other site
634457001101	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634457001102	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
634457001103	TPP-binding site [chemical binding]; other site
634457001104	benzoylformate decarboxylase; Reviewed; Region: PRK07092
634457001105	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634457001106	PYR/PP interface [polypeptide binding]; other site
634457001107	dimer interface [polypeptide binding]; other site
634457001108	TPP binding site [chemical binding]; other site
634457001109	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634457001110	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
634457001111	TPP-binding site [chemical binding]; other site
634457001112	dimer interface [polypeptide binding]; other site
634457001113	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
634457001114	Cysteine-rich domain; Region: CCG; pfam02754
634457001115	Cysteine-rich domain; Region: CCG; pfam02754
634457001116	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
634457001117	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
634457001118	4Fe-4S binding domain; Region: Fer4; pfam00037
634457001119	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
634457001120	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
634457001121	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
634457001122	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
634457001123	hinge; other site
634457001124	active site
634457001125	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
634457001126	trimer interface [polypeptide binding]; other site
634457001127	active site
634457001128	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634457001129	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
634457001130	putative active site [active]
634457001131	YdjC motif; other site
634457001132	Mg binding site [ion binding]; other site
634457001133	putative homodimer interface [polypeptide binding]; other site
634457001134	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
634457001135	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
634457001136	B12 binding site [chemical binding]; other site
634457001137	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457001138	FeS/SAM binding site; other site
634457001139	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
634457001140	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
634457001141	ligand binding site; other site
634457001142	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
634457001143	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
634457001144	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
634457001145	TPP-binding site; other site
634457001146	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634457001147	PYR/PP interface [polypeptide binding]; other site
634457001148	dimer interface [polypeptide binding]; other site
634457001149	TPP binding site [chemical binding]; other site
634457001150	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634457001151	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
634457001152	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457001153	FeS/SAM binding site; other site
634457001154	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
634457001155	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
634457001156	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
634457001157	Domain of unknown function DUF21; Region: DUF21; pfam01595
634457001158	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
634457001159	Transporter associated domain; Region: CorC_HlyC; smart01091
634457001160	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634457001161	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634457001162	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634457001163	catalytic residue [active]
634457001164	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
634457001165	Fe-S cluster binding site [ion binding]; other site
634457001166	active site
634457001167	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
634457001168	binding surface
634457001169	TPR motif; other site
634457001170	Tetratricopeptide repeat; Region: TPR_12; pfam13424
634457001171	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634457001172	TPR motif; other site
634457001173	TPR repeat; Region: TPR_11; pfam13414
634457001174	binding surface
634457001175	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
634457001176	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457001177	NAD(P) binding site [chemical binding]; other site
634457001178	active site
634457001179	Predicted membrane protein [Function unknown]; Region: COG1238
634457001180	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
634457001181	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
634457001182	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
634457001183	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
634457001184	Walker A/P-loop; other site
634457001185	ATP binding site [chemical binding]; other site
634457001186	Q-loop/lid; other site
634457001187	ABC transporter signature motif; other site
634457001188	Walker B; other site
634457001189	D-loop; other site
634457001190	H-loop/switch region; other site
634457001191	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
634457001192	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
634457001193	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
634457001194	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
634457001195	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634457001196	active site
634457001197	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634457001198	catalytic core [active]
634457001199	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
634457001200	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457001201	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634457001202	short chain dehydrogenase; Provisional; Region: PRK12744
634457001203	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457001204	NAD(P) binding site [chemical binding]; other site
634457001205	active site
634457001206	transcriptional regulator; Provisional; Region: PRK10632
634457001207	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457001208	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
634457001209	putative effector binding pocket; other site
634457001210	putative dimerization interface [polypeptide binding]; other site
634457001211	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634457001212	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
634457001213	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
634457001214	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634457001215	N-terminal plug; other site
634457001216	ligand-binding site [chemical binding]; other site
634457001217	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634457001218	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
634457001219	intersubunit interface [polypeptide binding]; other site
634457001220	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
634457001221	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
634457001222	putative PBP binding regions; other site
634457001223	ABC-ATPase subunit  interface; other site
634457001224	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
634457001225	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
634457001226	Walker A/P-loop; other site
634457001227	ATP binding site [chemical binding]; other site
634457001228	Q-loop/lid; other site
634457001229	ABC transporter signature motif; other site
634457001230	Walker B; other site
634457001231	D-loop; other site
634457001232	H-loop/switch region; other site
634457001233	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
634457001234	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
634457001235	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
634457001236	active site
634457001237	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
634457001238	nucleotide binding site [chemical binding]; other site
634457001239	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
634457001240	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
634457001241	putative active site [active]
634457001242	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
634457001243	Na binding site [ion binding]; other site
634457001244	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634457001245	long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584
634457001246	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457001247	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457001248	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457001249	Hint domain; Region: Hint_2; pfam13403
634457001250	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
634457001251	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
634457001252	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
634457001253	DNA binding residues [nucleotide binding]
634457001254	dimerization interface [polypeptide binding]; other site
634457001255	Hint domain; Region: Hint_2; pfam13403
634457001256	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
634457001257	DNA photolyase; Region: DNA_photolyase; pfam00875
634457001258	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
634457001259	SelR domain; Region: SelR; pfam01641
634457001260	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
634457001261	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634457001262	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634457001263	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
634457001264	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634457001265	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457001266	homodimer interface [polypeptide binding]; other site
634457001267	catalytic residue [active]
634457001268	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457001269	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457001270	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457001271	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457001272	Hint domain; Region: Hint_2; pfam13403
634457001273	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
634457001274	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
634457001275	dimerization interface [polypeptide binding]; other site
634457001276	DPS ferroxidase diiron center [ion binding]; other site
634457001277	ion pore; other site
634457001278	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
634457001279	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
634457001280	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
634457001281	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
634457001282	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
634457001283	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
634457001284	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457001285	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457001286	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634457001287	dimerization interface [polypeptide binding]; other site
634457001288	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
634457001289	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
634457001290	Methylamine utilisation protein MauE; Region: MauE; pfam07291
634457001291	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634457001292	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
634457001293	Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812
634457001294	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634457001295	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634457001296	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634457001297	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
634457001298	active site
634457001299	catalytic tetrad [active]
634457001300	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457001301	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457001302	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634457001303	dimerization interface [polypeptide binding]; other site
634457001304	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
634457001305	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634457001306	NAD binding site [chemical binding]; other site
634457001307	catalytic residues [active]
634457001308	substrate binding site [chemical binding]; other site
634457001309	Cytochrome c; Region: Cytochrom_C; cl11414
634457001310	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634457001311	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634457001312	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634457001313	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
634457001314	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634457001315	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634457001316	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634457001317	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
634457001318	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634457001319	catalytic loop [active]
634457001320	iron binding site [ion binding]; other site
634457001321	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634457001322	Protein of unknown function (DUF563); Region: DUF563; pfam04577
634457001323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457001324	S-adenosylmethionine binding site [chemical binding]; other site
634457001325	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
634457001326	Hint domain; Region: Hint_2; pfam13403
634457001327	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457001328	putative substrate translocation pore; other site
634457001329	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634457001330	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
634457001331	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457001332	Predicted integral membrane protein [Function unknown]; Region: COG0762
634457001333	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634457001334	Protein of unknown function (DUF805); Region: DUF805; pfam05656
634457001335	CHRD domain; Region: CHRD; pfam07452
634457001336	Predicted membrane protein [Function unknown]; Region: COG3650
634457001337	META domain; Region: META; pfam03724
634457001338	Hint domain; Region: Hint_2; pfam13403
634457001339	T5orf172 domain; Region: T5orf172; pfam10544
634457001340	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
634457001341	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634457001342	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634457001343	N-terminal plug; other site
634457001344	ligand-binding site [chemical binding]; other site
634457001345	Cytochrome c; Region: Cytochrom_C; pfam00034
634457001346	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
634457001347	FAD dependent oxidoreductase; Region: DAO; pfam01266
634457001348	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457001349	NmrA-like family; Region: NmrA; pfam05368
634457001350	NAD(P) binding site [chemical binding]; other site
634457001351	active site
634457001352	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
634457001353	Hint domain; Region: Hint_2; pfam13403
634457001354	Hint domain; Region: Hint_2; pfam13403
634457001355	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
634457001356	Hint domain; Region: Hint_2; pfam13403
634457001357	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634457001358	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634457001359	non-specific DNA binding site [nucleotide binding]; other site
634457001360	salt bridge; other site
634457001361	sequence-specific DNA binding site [nucleotide binding]; other site
634457001362	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634457001363	Catalytic site [active]
634457001364	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
634457001365	Hint domain; Region: Hint_2; pfam13403
634457001366	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634457001367	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634457001368	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634457001369	DNA-binding interface [nucleotide binding]; DNA binding site
634457001370	Hint domain; Region: Hint_2; pfam13403
634457001371	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
634457001372	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
634457001373	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457001374	FeS/SAM binding site; other site
634457001375	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
634457001376	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
634457001377	Terminase-like family; Region: Terminase_6; pfam03237
634457001378	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
634457001379	hypothetical protein; Validated; Region: PRK01415
634457001380	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
634457001381	active site residue [active]
634457001382	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
634457001383	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
634457001384	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
634457001385	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
634457001386	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
634457001387	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
634457001388	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
634457001389	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457001390	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
634457001391	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
634457001392	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634457001393	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634457001394	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457001395	Phosphotransferase enzyme family; Region: APH; pfam01636
634457001396	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
634457001397	substrate binding site [chemical binding]; other site
634457001398	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
634457001399	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
634457001400	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
634457001401	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
634457001402	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
634457001403	putative active site [active]
634457001404	putative substrate binding site [chemical binding]; other site
634457001405	putative cosubstrate binding site; other site
634457001406	catalytic site [active]
634457001407	Uncharacterized conserved protein [Function unknown]; Region: COG3189
634457001408	Predicted transcriptional regulator [Transcription]; Region: COG1959
634457001409	Transcriptional regulator; Region: Rrf2; cl17282
634457001410	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457001411	malonic semialdehyde reductase; Provisional; Region: PRK10538
634457001412	NAD(P) binding site [chemical binding]; other site
634457001413	active site
634457001414	CrcB-like protein; Region: CRCB; cl09114
634457001415	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
634457001416	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
634457001417	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
634457001418	dinuclear metal binding motif [ion binding]; other site
634457001419	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
634457001420	Hint domain; Region: Hint_2; pfam13403
634457001421	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
634457001422	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634457001423	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
634457001424	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
634457001425	active site
634457001426	Zn binding site [ion binding]; other site
634457001427	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634457001428	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457001429	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634457001430	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634457001431	Coenzyme A transferase; Region: CoA_trans; smart00882
634457001432	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457001433	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457001434	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457001435	Coenzyme A transferase; Region: CoA_trans; cl17247
634457001436	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
634457001437	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
634457001438	MOFRL family; Region: MOFRL; pfam05161
634457001439	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634457001440	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634457001441	active site
634457001442	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
634457001443	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457001444	NAD(P) binding site [chemical binding]; other site
634457001445	active site
634457001446	Protein of unknown function (DUF993); Region: DUF993; pfam06187
634457001447	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
634457001448	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
634457001449	DNA interaction; other site
634457001450	Metal-binding active site; metal-binding site
634457001451	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
634457001452	Electron transfer flavoprotein domain; Region: ETF; pfam01012
634457001453	Ligand binding site [chemical binding]; other site
634457001454	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457001455	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457001456	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457001457	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
634457001458	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
634457001459	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
634457001460	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634457001461	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
634457001462	NAD(P) binding site [chemical binding]; other site
634457001463	catalytic residues [active]
634457001464	choline dehydrogenase; Validated; Region: PRK02106
634457001465	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
634457001466	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
634457001467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457001468	putative substrate translocation pore; other site
634457001469	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634457001470	Hint domain; Region: Hint_2; pfam13403
634457001471	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457001472	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457001473	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457001474	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457001475	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
634457001476	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
634457001477	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
634457001478	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
634457001479	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
634457001480	tetramer interface [polypeptide binding]; other site
634457001481	TPP-binding site [chemical binding]; other site
634457001482	heterodimer interface [polypeptide binding]; other site
634457001483	phosphorylation loop region [posttranslational modification]
634457001484	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
634457001485	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
634457001486	alpha subunit interface [polypeptide binding]; other site
634457001487	TPP binding site [chemical binding]; other site
634457001488	heterodimer interface [polypeptide binding]; other site
634457001489	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634457001490	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
634457001491	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634457001492	E3 interaction surface; other site
634457001493	lipoyl attachment site [posttranslational modification]; other site
634457001494	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
634457001495	catalytic site [active]
634457001496	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
634457001497	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
634457001498	putative dimer interface [polypeptide binding]; other site
634457001499	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
634457001500	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634457001501	FOG: WD40 repeat [General function prediction only]; Region: COG2319
634457001502	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
634457001503	structural tetrad; other site
634457001504	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
634457001505	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
634457001506	P-loop, Walker A motif; other site
634457001507	Base recognition motif; other site
634457001508	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
634457001509	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
634457001510	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
634457001511	putative ion selectivity filter; other site
634457001512	putative pore gating glutamate residue; other site
634457001513	putative H+/Cl- coupling transport residue; other site
634457001514	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
634457001515	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
634457001516	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
634457001517	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
634457001518	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634457001519	acyl-CoA esterase; Provisional; Region: PRK10673
634457001520	PGAP1-like protein; Region: PGAP1; pfam07819
634457001521	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
634457001522	Ligand Binding Site [chemical binding]; other site
634457001523	Predicted membrane protein [Function unknown]; Region: COG1297
634457001524	putative oligopeptide transporter, OPT family; Region: TIGR00733
634457001525	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
634457001526	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
634457001527	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
634457001528	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
634457001529	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
634457001530	ATP binding site [chemical binding]; other site
634457001531	substrate interface [chemical binding]; other site
634457001532	Bacterial SH3 domain; Region: SH3_4; pfam06347
634457001533	Bacterial SH3 domain; Region: SH3_4; pfam06347
634457001534	pyruvate kinase; Provisional; Region: PRK06247
634457001535	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
634457001536	domain interfaces; other site
634457001537	active site
634457001538	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
634457001539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457001540	putative substrate translocation pore; other site
634457001541	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634457001542	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
634457001543	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
634457001544	G1 box; other site
634457001545	putative GEF interaction site [polypeptide binding]; other site
634457001546	GTP/Mg2+ binding site [chemical binding]; other site
634457001547	Switch I region; other site
634457001548	G2 box; other site
634457001549	G3 box; other site
634457001550	Switch II region; other site
634457001551	G4 box; other site
634457001552	G5 box; other site
634457001553	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
634457001554	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
634457001555	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
634457001556	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634457001557	hydroxyglutarate oxidase; Provisional; Region: PRK11728
634457001558	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
634457001559	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634457001560	isocitrate dehydrogenase; Validated; Region: PRK08299
634457001561	hypothetical protein; Provisional; Region: PRK08912
634457001562	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634457001563	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457001564	homodimer interface [polypeptide binding]; other site
634457001565	catalytic residue [active]
634457001566	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
634457001567	Nitrogen regulatory protein P-II; Region: P-II; smart00938
634457001568	glutamine synthetase; Provisional; Region: glnA; PRK09469
634457001569	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
634457001570	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
634457001571	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634457001572	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
634457001573	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
634457001574	Trp docking motif [polypeptide binding]; other site
634457001575	putative active site [active]
634457001576	Predicted transcriptional regulator [Transcription]; Region: COG2932
634457001577	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634457001578	Catalytic site [active]
634457001579	GTP-binding protein LepA; Provisional; Region: PRK05433
634457001580	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
634457001581	G1 box; other site
634457001582	putative GEF interaction site [polypeptide binding]; other site
634457001583	GTP/Mg2+ binding site [chemical binding]; other site
634457001584	Switch I region; other site
634457001585	G2 box; other site
634457001586	G3 box; other site
634457001587	Switch II region; other site
634457001588	G4 box; other site
634457001589	G5 box; other site
634457001590	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
634457001591	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
634457001592	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
634457001593	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
634457001594	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
634457001595	Methyltransferase domain; Region: Methyltransf_23; pfam13489
634457001596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457001597	S-adenosylmethionine binding site [chemical binding]; other site
634457001598	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634457001599	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634457001600	ATP binding site [chemical binding]; other site
634457001601	Mg++ binding site [ion binding]; other site
634457001602	motif III; other site
634457001603	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634457001604	nucleotide binding region [chemical binding]; other site
634457001605	ATP-binding site [chemical binding]; other site
634457001606	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
634457001607	putative catalytic site [active]
634457001608	putative metal binding site [ion binding]; other site
634457001609	putative phosphate binding site [ion binding]; other site
634457001610	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
634457001611	active site clefts [active]
634457001612	zinc binding site [ion binding]; other site
634457001613	dimer interface [polypeptide binding]; other site
634457001614	LabA_like proteins; Region: LabA; cd10911
634457001615	Uncharacterized conserved protein [Function unknown]; Region: COG1432
634457001616	putative metal binding site [ion binding]; other site
634457001617	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
634457001618	catalytic center binding site [active]
634457001619	ATP binding site [chemical binding]; other site
634457001620	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
634457001621	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
634457001622	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
634457001623	Zn2+ binding site [ion binding]; other site
634457001624	Mg2+ binding site [ion binding]; other site
634457001625	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
634457001626	synthetase active site [active]
634457001627	NTP binding site [chemical binding]; other site
634457001628	metal binding site [ion binding]; metal-binding site
634457001629	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
634457001630	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
634457001631	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
634457001632	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
634457001633	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
634457001634	Catalytic site [active]
634457001635	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
634457001636	ribonuclease III; Reviewed; Region: rnc; PRK00102
634457001637	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
634457001638	dimerization interface [polypeptide binding]; other site
634457001639	active site
634457001640	metal binding site [ion binding]; metal-binding site
634457001641	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
634457001642	GTPase Era; Reviewed; Region: era; PRK00089
634457001643	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
634457001644	G1 box; other site
634457001645	GTP/Mg2+ binding site [chemical binding]; other site
634457001646	Switch I region; other site
634457001647	G2 box; other site
634457001648	Switch II region; other site
634457001649	G3 box; other site
634457001650	G4 box; other site
634457001651	G5 box; other site
634457001652	KH domain; Region: KH_2; pfam07650
634457001653	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
634457001654	putative nucleotide binding site [chemical binding]; other site
634457001655	uridine monophosphate binding site [chemical binding]; other site
634457001656	homohexameric interface [polypeptide binding]; other site
634457001657	ribosome recycling factor; Reviewed; Region: frr; PRK00083
634457001658	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
634457001659	hinge region; other site
634457001660	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
634457001661	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
634457001662	catalytic residue [active]
634457001663	putative FPP diphosphate  binding site; other site
634457001664	putative FPP binding hydrophobic cleft; other site
634457001665	dimer interface [polypeptide binding]; other site
634457001666	putative IPP diphosphate binding site; other site
634457001667	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
634457001668	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
634457001669	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
634457001670	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
634457001671	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
634457001672	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
634457001673	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
634457001674	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
634457001675	active site
634457001676	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
634457001677	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
634457001678	putative substrate binding region [chemical binding]; other site
634457001679	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634457001680	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
634457001681	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634457001682	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634457001683	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634457001684	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634457001685	Surface antigen; Region: Bac_surface_Ag; pfam01103
634457001686	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
634457001687	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
634457001688	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
634457001689	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
634457001690	trimer interface [polypeptide binding]; other site
634457001691	active site
634457001692	UDP-GlcNAc binding site [chemical binding]; other site
634457001693	lipid binding site [chemical binding]; lipid-binding site
634457001694	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
634457001695	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
634457001696	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
634457001697	active site
634457001698	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
634457001699	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
634457001700	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
634457001701	dimer interface [polypeptide binding]; other site
634457001702	active site
634457001703	metal binding site [ion binding]; metal-binding site
634457001704	glutathione binding site [chemical binding]; other site
634457001705	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
634457001706	Ribonuclease P; Region: Ribonuclease_P; pfam00825
634457001707	membrane protein insertase; Provisional; Region: PRK01318
634457001708	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
634457001709	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
634457001710	G1 box; other site
634457001711	GTP/Mg2+ binding site [chemical binding]; other site
634457001712	Switch I region; other site
634457001713	G2 box; other site
634457001714	G3 box; other site
634457001715	Switch II region; other site
634457001716	G4 box; other site
634457001717	G5 box; other site
634457001718	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
634457001719	homohexameric interface [polypeptide binding]; other site
634457001720	feedback inhibition sensing region; other site
634457001721	nucleotide binding site [chemical binding]; other site
634457001722	N-acetyl-L-glutamate binding site [chemical binding]; other site
634457001723	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
634457001724	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
634457001725	trimer interface [polypeptide binding]; other site
634457001726	active site
634457001727	substrate binding site [chemical binding]; other site
634457001728	CoA binding site [chemical binding]; other site
634457001729	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
634457001730	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
634457001731	metal binding site [ion binding]; metal-binding site
634457001732	dimer interface [polypeptide binding]; other site
634457001733	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
634457001734	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
634457001735	dimerization interface 3.5A [polypeptide binding]; other site
634457001736	active site
634457001737	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
634457001738	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
634457001739	putative active site [active]
634457001740	substrate binding site [chemical binding]; other site
634457001741	putative cosubstrate binding site; other site
634457001742	catalytic site [active]
634457001743	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
634457001744	substrate binding site [chemical binding]; other site
634457001745	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
634457001746	active site
634457001747	catalytic residues [active]
634457001748	metal binding site [ion binding]; metal-binding site
634457001749	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
634457001750	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
634457001751	putative dimer interface [polypeptide binding]; other site
634457001752	Protein of unknown function (DUF1150); Region: DUF1150; cl11577
634457001753	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
634457001754	30S subunit binding site; other site
634457001755	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
634457001756	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
634457001757	MOSC domain; Region: MOSC; pfam03473
634457001758	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
634457001759	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
634457001760	Walker A/P-loop; other site
634457001761	ATP binding site [chemical binding]; other site
634457001762	Q-loop/lid; other site
634457001763	ABC transporter signature motif; other site
634457001764	Walker B; other site
634457001765	D-loop; other site
634457001766	H-loop/switch region; other site
634457001767	OstA-like protein; Region: OstA; cl00844
634457001768	OstA-like protein; Region: OstA; cl00844
634457001769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
634457001770	KpsF/GutQ family protein; Region: kpsF; TIGR00393
634457001771	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
634457001772	putative active site [active]
634457001773	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
634457001774	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
634457001775	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
634457001776	catalytic site [active]
634457001777	putative active site [active]
634457001778	putative substrate binding site [chemical binding]; other site
634457001779	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
634457001780	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
634457001781	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
634457001782	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
634457001783	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634457001784	short chain dehydrogenase; Provisional; Region: PRK07024
634457001785	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457001786	NAD(P) binding site [chemical binding]; other site
634457001787	active site
634457001788	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
634457001789	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
634457001790	catalytic site [active]
634457001791	G-X2-G-X-G-K; other site
634457001792	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
634457001793	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
634457001794	putative ribose interaction site [chemical binding]; other site
634457001795	putative ADP binding site [chemical binding]; other site
634457001796	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
634457001797	active site
634457001798	nucleotide binding site [chemical binding]; other site
634457001799	HIGH motif; other site
634457001800	KMSKS motif; other site
634457001801	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
634457001802	dimerization interface [polypeptide binding]; other site
634457001803	putative active cleft [active]
634457001804	replicative DNA helicase; Provisional; Region: PRK09165
634457001805	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
634457001806	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
634457001807	Walker A motif; other site
634457001808	ATP binding site [chemical binding]; other site
634457001809	Walker B motif; other site
634457001810	DNA binding loops [nucleotide binding]
634457001811	Nuclease-related domain; Region: NERD; pfam08378
634457001812	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
634457001813	Mechanosensitive ion channel; Region: MS_channel; pfam00924
634457001814	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
634457001815	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
634457001816	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457001817	Walker A/P-loop; other site
634457001818	ATP binding site [chemical binding]; other site
634457001819	Q-loop/lid; other site
634457001820	ABC transporter signature motif; other site
634457001821	Walker B; other site
634457001822	D-loop; other site
634457001823	H-loop/switch region; other site
634457001824	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
634457001825	Permease; Region: Permease; pfam02405
634457001826	DNA repair protein RadA; Provisional; Region: PRK11823
634457001827	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
634457001828	Walker A motif/ATP binding site; other site
634457001829	ATP binding site [chemical binding]; other site
634457001830	Walker B motif; other site
634457001831	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
634457001832	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
634457001833	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634457001834	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
634457001835	Proline dehydrogenase; Region: Pro_dh; pfam01619
634457001836	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
634457001837	NAD(P) binding site [chemical binding]; other site
634457001838	catalytic residues [active]
634457001839	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
634457001840	Transcriptional regulators [Transcription]; Region: GntR; COG1802
634457001841	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634457001842	DNA-binding site [nucleotide binding]; DNA binding site
634457001843	FCD domain; Region: FCD; pfam07729
634457001844	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
634457001845	acetyl-CoA synthetase; Provisional; Region: PRK00174
634457001846	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
634457001847	acyl-activating enzyme (AAE) consensus motif; other site
634457001848	AMP binding site [chemical binding]; other site
634457001849	active site
634457001850	CoA binding site [chemical binding]; other site
634457001851	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
634457001852	FtsJ-like methyltransferase; Region: FtsJ; cl17430
634457001853	Protein of unknown function (DUF423); Region: DUF423; pfam04241
634457001854	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
634457001855	hypothetical protein; Validated; Region: PRK09039
634457001856	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
634457001857	FAD binding domain; Region: FAD_binding_4; pfam01565
634457001858	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
634457001859	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
634457001860	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
634457001861	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634457001862	active site
634457001863	multifunctional aminopeptidase A; Provisional; Region: PRK00913
634457001864	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
634457001865	interface (dimer of trimers) [polypeptide binding]; other site
634457001866	Substrate-binding/catalytic site; other site
634457001867	Zn-binding sites [ion binding]; other site
634457001868	DNA polymerase III subunit chi; Validated; Region: PRK05728
634457001869	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634457001870	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
634457001871	active site
634457001872	catalytic tetrad [active]
634457001873	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
634457001874	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
634457001875	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634457001876	protein binding site [polypeptide binding]; other site
634457001877	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
634457001878	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634457001879	ATP binding site [chemical binding]; other site
634457001880	putative Mg++ binding site [ion binding]; other site
634457001881	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634457001882	nucleotide binding region [chemical binding]; other site
634457001883	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
634457001884	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
634457001885	dimerization interface [polypeptide binding]; other site
634457001886	domain crossover interface; other site
634457001887	redox-dependent activation switch; other site
634457001888	ornithine carbamoyltransferase; Provisional; Region: PRK00779
634457001889	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
634457001890	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
634457001891	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
634457001892	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634457001893	inhibitor-cofactor binding pocket; inhibition site
634457001894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457001895	catalytic residue [active]
634457001896	RecX family; Region: RecX; pfam02631
634457001897	CHAP domain; Region: CHAP; cl17642
634457001898	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
634457001899	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
634457001900	intersubunit interface [polypeptide binding]; other site
634457001901	active site
634457001902	Zn2+ binding site [ion binding]; other site
634457001903	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
634457001904	Cupin domain; Region: Cupin_2; cl17218
634457001905	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
634457001906	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
634457001907	motif II; other site
634457001908	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
634457001909	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
634457001910	active site
634457001911	Riboflavin kinase; Region: Flavokinase; smart00904
634457001912	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
634457001913	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634457001914	active site
634457001915	HIGH motif; other site
634457001916	nucleotide binding site [chemical binding]; other site
634457001917	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
634457001918	active site
634457001919	KMSKS motif; other site
634457001920	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
634457001921	tRNA binding surface [nucleotide binding]; other site
634457001922	anticodon binding site; other site
634457001923	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
634457001924	lipoprotein signal peptidase; Provisional; Region: PRK14770
634457001925	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
634457001926	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
634457001927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457001928	ATP binding site [chemical binding]; other site
634457001929	Mg2+ binding site [ion binding]; other site
634457001930	G-X-G motif; other site
634457001931	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
634457001932	ATP binding site [chemical binding]; other site
634457001933	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
634457001934	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
634457001935	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
634457001936	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
634457001937	EamA-like transporter family; Region: EamA; pfam00892
634457001938	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
634457001939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457001940	Mg2+ binding site [ion binding]; other site
634457001941	G-X-G motif; other site
634457001942	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
634457001943	anchoring element; other site
634457001944	dimer interface [polypeptide binding]; other site
634457001945	ATP binding site [chemical binding]; other site
634457001946	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
634457001947	active site
634457001948	putative metal-binding site [ion binding]; other site
634457001949	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
634457001950	Rrf2 family protein; Region: rrf2_super; TIGR00738
634457001951	Transcriptional regulator; Region: Rrf2; pfam02082
634457001952	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
634457001953	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
634457001954	dimer interface [polypeptide binding]; other site
634457001955	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457001956	catalytic residue [active]
634457001957	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
634457001958	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634457001959	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634457001960	ligand binding site [chemical binding]; other site
634457001961	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
634457001962	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
634457001963	C-terminal peptidase (prc); Region: prc; TIGR00225
634457001964	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
634457001965	protein binding site [polypeptide binding]; other site
634457001966	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
634457001967	Catalytic dyad [active]
634457001968	Exoribonuclease R [Transcription]; Region: VacB; COG0557
634457001969	RNB domain; Region: RNB; pfam00773
634457001970	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
634457001971	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
634457001972	active site
634457001973	interdomain interaction site; other site
634457001974	putative metal-binding site [ion binding]; other site
634457001975	nucleotide binding site [chemical binding]; other site
634457001976	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
634457001977	domain I; other site
634457001978	DNA binding groove [nucleotide binding]
634457001979	phosphate binding site [ion binding]; other site
634457001980	domain II; other site
634457001981	domain III; other site
634457001982	nucleotide binding site [chemical binding]; other site
634457001983	catalytic site [active]
634457001984	domain IV; other site
634457001985	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
634457001986	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
634457001987	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
634457001988	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
634457001989	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
634457001990	DNA protecting protein DprA; Region: dprA; TIGR00732
634457001991	DDE superfamily endonuclease; Region: DDE_5; pfam13546
634457001992	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457001993	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457001994	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
634457001995	DNA protecting protein DprA; Region: dprA; TIGR00732
634457001996	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
634457001997	dihydroorotase; Validated; Region: pyrC; PRK09357
634457001998	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634457001999	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
634457002000	active site
634457002001	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
634457002002	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
634457002003	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
634457002004	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
634457002005	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634457002006	active site
634457002007	HIGH motif; other site
634457002008	nucleotide binding site [chemical binding]; other site
634457002009	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
634457002010	active site
634457002011	KMSKS motif; other site
634457002012	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
634457002013	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
634457002014	Competence protein; Region: Competence; pfam03772
634457002015	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
634457002016	Predicted ATPase [General function prediction only]; Region: COG1485
634457002017	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
634457002018	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
634457002019	TPP-binding site [chemical binding]; other site
634457002020	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
634457002021	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
634457002022	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634457002023	E3 interaction surface; other site
634457002024	lipoyl attachment site [posttranslational modification]; other site
634457002025	e3 binding domain; Region: E3_binding; pfam02817
634457002026	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
634457002027	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634457002028	E3 interaction surface; other site
634457002029	lipoyl attachment site [posttranslational modification]; other site
634457002030	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
634457002031	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634457002032	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634457002033	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
634457002034	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
634457002035	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
634457002036	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
634457002037	homotetramer interface [polypeptide binding]; other site
634457002038	ligand binding site [chemical binding]; other site
634457002039	catalytic site [active]
634457002040	NAD binding site [chemical binding]; other site
634457002041	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
634457002042	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
634457002043	putative acyl-acceptor binding pocket; other site
634457002044	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
634457002045	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
634457002046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
634457002047	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
634457002048	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
634457002049	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
634457002050	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
634457002051	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
634457002052	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
634457002053	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
634457002054	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
634457002055	motif 1; other site
634457002056	active site
634457002057	motif 2; other site
634457002058	motif 3; other site
634457002059	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
634457002060	TraB family; Region: TraB; cl12050
634457002061	Predicted membrane protein [Function unknown]; Region: COG2246
634457002062	GtrA-like protein; Region: GtrA; pfam04138
634457002063	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
634457002064	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634457002065	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634457002066	ligand binding site [chemical binding]; other site
634457002067	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
634457002068	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
634457002069	ADP binding site [chemical binding]; other site
634457002070	magnesium binding site [ion binding]; other site
634457002071	putative shikimate binding site; other site
634457002072	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
634457002073	active site
634457002074	dimer interface [polypeptide binding]; other site
634457002075	metal binding site [ion binding]; metal-binding site
634457002076	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
634457002077	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457002078	active site
634457002079	DNA binding site [nucleotide binding]
634457002080	Int/Topo IB signature motif; other site
634457002081	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
634457002082	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
634457002083	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
634457002084	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
634457002085	putative MPT binding site; other site
634457002086	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
634457002087	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634457002088	active site
634457002089	nucleotide binding site [chemical binding]; other site
634457002090	HIGH motif; other site
634457002091	KMSKS motif; other site
634457002092	Predicted integral membrane protein [Function unknown]; Region: COG0392
634457002093	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
634457002094	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
634457002095	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
634457002096	UGMP family protein; Validated; Region: PRK09604
634457002097	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
634457002098	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
634457002099	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
634457002100	domain interfaces; other site
634457002101	active site
634457002102	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
634457002103	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
634457002104	active site
634457002105	preprotein translocase subunit SecB; Validated; Region: PRK05751
634457002106	SecA binding site; other site
634457002107	Preprotein binding site; other site
634457002108	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634457002109	catalytic core [active]
634457002110	Tim44-like domain; Region: Tim44; pfam04280
634457002111	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
634457002112	DNA methylase; Region: N6_N4_Mtase; pfam01555
634457002113	Haem-binding domain; Region: Haem_bd; pfam14376
634457002114	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
634457002115	Smr domain; Region: Smr; pfam01713
634457002116	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
634457002117	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
634457002118	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
634457002119	Qi binding site; other site
634457002120	intrachain domain interface; other site
634457002121	interchain domain interface [polypeptide binding]; other site
634457002122	heme bH binding site [chemical binding]; other site
634457002123	heme bL binding site [chemical binding]; other site
634457002124	Qo binding site; other site
634457002125	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
634457002126	intrachain domain interface; other site
634457002127	interchain domain interface [polypeptide binding]; other site
634457002128	Qi binding site; other site
634457002129	Qo binding site; other site
634457002130	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
634457002131	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
634457002132	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
634457002133	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
634457002134	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
634457002135	FMN binding site [chemical binding]; other site
634457002136	dimer interface [polypeptide binding]; other site
634457002137	ornithine cyclodeaminase; Validated; Region: PRK07340
634457002138	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
634457002139	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
634457002140	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
634457002141	NAD(P) binding site [chemical binding]; other site
634457002142	catalytic residues [active]
634457002143	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634457002144	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634457002145	WHG domain; Region: WHG; pfam13305
634457002146	Transposase; Region: HTH_Tnp_1; pfam01527
634457002147	HTH-like domain; Region: HTH_21; pfam13276
634457002148	Integrase core domain; Region: rve; pfam00665
634457002149	Integrase core domain; Region: rve_3; pfam13683
634457002150	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457002151	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634457002152	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634457002153	catalytic residues [active]
634457002154	catalytic nucleophile [active]
634457002155	Presynaptic Site I dimer interface [polypeptide binding]; other site
634457002156	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634457002157	Synaptic Flat tetramer interface [polypeptide binding]; other site
634457002158	Synaptic Site I dimer interface [polypeptide binding]; other site
634457002159	DNA binding site [nucleotide binding]
634457002160	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634457002161	DNA-binding interface [nucleotide binding]; DNA binding site
634457002162	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457002163	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457002164	active site
634457002165	DNA binding site [nucleotide binding]
634457002166	Int/Topo IB signature motif; other site
634457002167	integrase; Provisional; Region: PRK09692
634457002168	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
634457002169	active site
634457002170	Int/Topo IB signature motif; other site
634457002171	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889
634457002172	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
634457002173	HicB family; Region: HicB; pfam05534
634457002174	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
634457002175	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
634457002176	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
634457002177	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457002178	Walker A/P-loop; other site
634457002179	ATP binding site [chemical binding]; other site
634457002180	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
634457002181	synthetase active site [active]
634457002182	NTP binding site [chemical binding]; other site
634457002183	metal binding site [ion binding]; metal-binding site
634457002184	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634457002185	Transposase; Region: HTH_Tnp_1; pfam01527
634457002186	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634457002187	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634457002188	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634457002189	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634457002190	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634457002191	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634457002192	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634457002193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634457002194	HTH-like domain; Region: HTH_21; pfam13276
634457002195	Integrase core domain; Region: rve; pfam00665
634457002196	Integrase core domain; Region: rve_3; pfam13683
634457002197	Transposase; Region: HTH_Tnp_1; pfam01527
634457002198	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634457002199	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634457002200	non-specific DNA binding site [nucleotide binding]; other site
634457002201	salt bridge; other site
634457002202	sequence-specific DNA binding site [nucleotide binding]; other site
634457002203	hypothetical protein; Validated; Region: PRK07078
634457002204	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
634457002205	active site
634457002206	metal binding site [ion binding]; metal-binding site
634457002207	interdomain interaction site; other site
634457002208	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
634457002209	Domain of unknown function (DUF927); Region: DUF927; pfam06048
634457002210	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
634457002211	active site
634457002212	oligomerization interface [polypeptide binding]; other site
634457002213	metal binding site [ion binding]; metal-binding site
634457002214	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
634457002215	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
634457002216	active site
634457002217	FMN binding site [chemical binding]; other site
634457002218	substrate binding site [chemical binding]; other site
634457002219	homotetramer interface [polypeptide binding]; other site
634457002220	catalytic residue [active]
634457002221	Helix-turn-helix domain; Region: HTH_20; pfam12840
634457002222	dimerization interface [polypeptide binding]; other site
634457002223	putative DNA binding site [nucleotide binding]; other site
634457002224	putative Zn2+ binding site [ion binding]; other site
634457002225	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
634457002226	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
634457002227	putative NAD(P) binding site [chemical binding]; other site
634457002228	putative substrate binding site [chemical binding]; other site
634457002229	catalytic Zn binding site [ion binding]; other site
634457002230	structural Zn binding site [ion binding]; other site
634457002231	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
634457002232	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
634457002233	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
634457002234	NAD binding site [chemical binding]; other site
634457002235	homodimer interface [polypeptide binding]; other site
634457002236	active site
634457002237	substrate binding site [chemical binding]; other site
634457002238	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
634457002239	diaminopimelate decarboxylase; Region: lysA; TIGR01048
634457002240	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
634457002241	active site
634457002242	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634457002243	substrate binding site [chemical binding]; other site
634457002244	catalytic residues [active]
634457002245	dimer interface [polypeptide binding]; other site
634457002246	argininosuccinate lyase; Provisional; Region: PRK00855
634457002247	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
634457002248	active sites [active]
634457002249	tetramer interface [polypeptide binding]; other site
634457002250	N-formylglutamate amidohydrolase; Region: FGase; cl01522
634457002251	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
634457002252	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
634457002253	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
634457002254	shikimate binding site; other site
634457002255	NAD(P) binding site [chemical binding]; other site
634457002256	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
634457002257	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
634457002258	CoA-binding site [chemical binding]; other site
634457002259	ATP-binding [chemical binding]; other site
634457002260	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
634457002261	active site
634457002262	catalytic site [active]
634457002263	substrate binding site [chemical binding]; other site
634457002264	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457002265	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
634457002266	putative ADP-binding pocket [chemical binding]; other site
634457002267	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
634457002268	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
634457002269	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
634457002270	substrate binding site [chemical binding]; other site
634457002271	hexamer interface [polypeptide binding]; other site
634457002272	metal binding site [ion binding]; metal-binding site
634457002273	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
634457002274	putative RNA binding site [nucleotide binding]; other site
634457002275	16S rRNA methyltransferase B; Provisional; Region: PRK10901
634457002276	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457002277	S-adenosylmethionine binding site [chemical binding]; other site
634457002278	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
634457002279	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
634457002280	active site
634457002281	substrate binding site [chemical binding]; other site
634457002282	cosubstrate binding site; other site
634457002283	catalytic site [active]
634457002284	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
634457002285	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
634457002286	dimerization interface [polypeptide binding]; other site
634457002287	putative ATP binding site [chemical binding]; other site
634457002288	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
634457002289	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
634457002290	polyphosphate kinase; Provisional; Region: PRK05443
634457002291	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
634457002292	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
634457002293	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
634457002294	putative domain interface [polypeptide binding]; other site
634457002295	putative active site [active]
634457002296	catalytic site [active]
634457002297	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
634457002298	putative domain interface [polypeptide binding]; other site
634457002299	putative active site [active]
634457002300	catalytic site [active]
634457002301	exopolyphosphatase; Region: exo_poly_only; TIGR03706
634457002302	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
634457002303	Cache domain; Region: Cache_1; pfam02743
634457002304	cyclase homology domain; Region: CHD; cd07302
634457002305	nucleotidyl binding site; other site
634457002306	metal binding site [ion binding]; metal-binding site
634457002307	dimer interface [polypeptide binding]; other site
634457002308	Permease; Region: Permease; pfam02405
634457002309	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
634457002310	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457002311	Q-loop/lid; other site
634457002312	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
634457002313	mce related protein; Region: MCE; pfam02470
634457002314	sugar binding site [chemical binding]; other site
634457002315	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
634457002316	Inward rectifier potassium channel; Region: IRK; pfam01007
634457002317	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634457002318	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634457002319	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634457002320	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634457002321	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
634457002322	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
634457002323	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
634457002324	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
634457002325	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
634457002326	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
634457002327	catalytic residues [active]
634457002328	central insert; other site
634457002329	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
634457002330	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
634457002331	heme exporter protein CcmC; Region: ccmC; TIGR01191
634457002332	YciI-like protein; Reviewed; Region: PRK12863
634457002333	EVE domain; Region: EVE; pfam01878
634457002334	Putative phosphatase (DUF442); Region: DUF442; cl17385
634457002335	EcsC protein family; Region: EcsC; pfam12787
634457002336	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
634457002337	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
634457002338	dimerization interface [polypeptide binding]; other site
634457002339	ligand binding site [chemical binding]; other site
634457002340	NADP binding site [chemical binding]; other site
634457002341	catalytic site [active]
634457002342	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
634457002343	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
634457002344	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
634457002345	Protein of unknown function; Region: DUF3971; pfam13116
634457002346	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634457002347	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
634457002348	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
634457002349	metal binding triad; other site
634457002350	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
634457002351	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
634457002352	metal binding triad; other site
634457002353	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
634457002354	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
634457002355	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
634457002356	catalytic triad [active]
634457002357	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
634457002358	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457002359	putative substrate translocation pore; other site
634457002360	RmuC family; Region: RmuC; pfam02646
634457002361	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634457002362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457002363	active site
634457002364	phosphorylation site [posttranslational modification]
634457002365	intermolecular recognition site; other site
634457002366	dimerization interface [polypeptide binding]; other site
634457002367	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634457002368	DNA binding site [nucleotide binding]
634457002369	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634457002370	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634457002371	dimerization interface [polypeptide binding]; other site
634457002372	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457002373	ATP binding site [chemical binding]; other site
634457002374	Mg2+ binding site [ion binding]; other site
634457002375	G-X-G motif; other site
634457002376	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
634457002377	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634457002378	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634457002379	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457002380	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634457002381	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
634457002382	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
634457002383	23S rRNA interface [nucleotide binding]; other site
634457002384	L7/L12 interface [polypeptide binding]; other site
634457002385	putative thiostrepton binding site; other site
634457002386	L25 interface [polypeptide binding]; other site
634457002387	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
634457002388	mRNA/rRNA interface [nucleotide binding]; other site
634457002389	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
634457002390	23S rRNA interface [nucleotide binding]; other site
634457002391	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
634457002392	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
634457002393	L11 interface [polypeptide binding]; other site
634457002394	putative EF-Tu interaction site [polypeptide binding]; other site
634457002395	putative EF-G interaction site [polypeptide binding]; other site
634457002396	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
634457002397	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
634457002398	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
634457002399	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
634457002400	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
634457002401	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
634457002402	RPB1 interaction site [polypeptide binding]; other site
634457002403	RPB11 interaction site [polypeptide binding]; other site
634457002404	RPB10 interaction site [polypeptide binding]; other site
634457002405	RPB3 interaction site [polypeptide binding]; other site
634457002406	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
634457002407	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
634457002408	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
634457002409	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
634457002410	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
634457002411	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
634457002412	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
634457002413	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
634457002414	DNA binding site [nucleotide binding]
634457002415	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
634457002416	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
634457002417	S17 interaction site [polypeptide binding]; other site
634457002418	S8 interaction site; other site
634457002419	16S rRNA interaction site [nucleotide binding]; other site
634457002420	streptomycin interaction site [chemical binding]; other site
634457002421	23S rRNA interaction site [nucleotide binding]; other site
634457002422	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
634457002423	30S ribosomal protein S7; Validated; Region: PRK05302
634457002424	elongation factor Tu; Reviewed; Region: PRK00049
634457002425	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
634457002426	G1 box; other site
634457002427	GEF interaction site [polypeptide binding]; other site
634457002428	GTP/Mg2+ binding site [chemical binding]; other site
634457002429	Switch I region; other site
634457002430	G2 box; other site
634457002431	G3 box; other site
634457002432	Switch II region; other site
634457002433	G4 box; other site
634457002434	G5 box; other site
634457002435	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
634457002436	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
634457002437	Antibiotic Binding Site [chemical binding]; other site
634457002438	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
634457002439	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
634457002440	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
634457002441	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
634457002442	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
634457002443	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
634457002444	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
634457002445	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
634457002446	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
634457002447	putative translocon binding site; other site
634457002448	protein-rRNA interface [nucleotide binding]; other site
634457002449	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
634457002450	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
634457002451	G-X-X-G motif; other site
634457002452	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
634457002453	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
634457002454	23S rRNA interface [nucleotide binding]; other site
634457002455	5S rRNA interface [nucleotide binding]; other site
634457002456	putative antibiotic binding site [chemical binding]; other site
634457002457	L25 interface [polypeptide binding]; other site
634457002458	L27 interface [polypeptide binding]; other site
634457002459	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
634457002460	23S rRNA interface [nucleotide binding]; other site
634457002461	putative translocon interaction site; other site
634457002462	signal recognition particle (SRP54) interaction site; other site
634457002463	L23 interface [polypeptide binding]; other site
634457002464	trigger factor interaction site; other site
634457002465	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
634457002466	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
634457002467	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
634457002468	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
634457002469	RNA binding site [nucleotide binding]; other site
634457002470	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
634457002471	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
634457002472	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
634457002473	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
634457002474	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
634457002475	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
634457002476	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
634457002477	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
634457002478	5S rRNA interface [nucleotide binding]; other site
634457002479	23S rRNA interface [nucleotide binding]; other site
634457002480	L5 interface [polypeptide binding]; other site
634457002481	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
634457002482	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
634457002483	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
634457002484	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
634457002485	23S rRNA binding site [nucleotide binding]; other site
634457002486	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
634457002487	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
634457002488	SecY translocase; Region: SecY; pfam00344
634457002489	adenylate kinase; Reviewed; Region: adk; PRK00279
634457002490	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
634457002491	AMP-binding site [chemical binding]; other site
634457002492	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
634457002493	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
634457002494	30S ribosomal protein S13; Region: bact_S13; TIGR03631
634457002495	30S ribosomal protein S11; Validated; Region: PRK05309
634457002496	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
634457002497	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
634457002498	alphaNTD - beta interaction site [polypeptide binding]; other site
634457002499	alphaNTD homodimer interface [polypeptide binding]; other site
634457002500	alphaNTD - beta' interaction site [polypeptide binding]; other site
634457002501	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
634457002502	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
634457002503	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
634457002504	NMT1-like family; Region: NMT1_2; pfam13379
634457002505	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634457002506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457002507	dimer interface [polypeptide binding]; other site
634457002508	conserved gate region; other site
634457002509	putative PBP binding loops; other site
634457002510	ABC-ATPase subunit interface; other site
634457002511	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634457002512	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634457002513	Walker A/P-loop; other site
634457002514	ATP binding site [chemical binding]; other site
634457002515	Q-loop/lid; other site
634457002516	ABC transporter signature motif; other site
634457002517	Walker B; other site
634457002518	D-loop; other site
634457002519	H-loop/switch region; other site
634457002520	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634457002521	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
634457002522	Protein export membrane protein; Region: SecD_SecF; cl14618
634457002523	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
634457002524	Protein export membrane protein; Region: SecD_SecF; cl14618
634457002525	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
634457002526	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634457002527	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457002528	putative transporter; Provisional; Region: PRK10504
634457002529	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457002530	putative substrate translocation pore; other site
634457002531	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457002532	CsbD-like; Region: CsbD; pfam05532
634457002533	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
634457002534	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
634457002535	RNA/DNA hybrid binding site [nucleotide binding]; other site
634457002536	active site
634457002537	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
634457002538	DNA methylase; Region: N6_N4_Mtase; pfam01555
634457002539	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
634457002540	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
634457002541	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
634457002542	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
634457002543	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
634457002544	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
634457002545	Protein of unknown function DUF58; Region: DUF58; pfam01882
634457002546	MoxR-like ATPases [General function prediction only]; Region: COG0714
634457002547	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
634457002548	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
634457002549	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
634457002550	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
634457002551	active site
634457002552	NTP binding site [chemical binding]; other site
634457002553	metal binding triad [ion binding]; metal-binding site
634457002554	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
634457002555	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634457002556	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634457002557	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457002558	Walker A/P-loop; other site
634457002559	ATP binding site [chemical binding]; other site
634457002560	Q-loop/lid; other site
634457002561	ABC transporter signature motif; other site
634457002562	Walker B; other site
634457002563	D-loop; other site
634457002564	H-loop/switch region; other site
634457002565	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
634457002566	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634457002567	E3 interaction surface; other site
634457002568	lipoyl attachment site [posttranslational modification]; other site
634457002569	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457002570	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634457002571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457002572	putative substrate translocation pore; other site
634457002573	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
634457002574	putative active site [active]
634457002575	Ap4A binding site [chemical binding]; other site
634457002576	nudix motif; other site
634457002577	putative metal binding site [ion binding]; other site
634457002578	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
634457002579	NodB motif; other site
634457002580	putative active site [active]
634457002581	putative catalytic site [active]
634457002582	Zn binding site [ion binding]; other site
634457002583	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
634457002584	C-terminal peptidase (prc); Region: prc; TIGR00225
634457002585	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
634457002586	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
634457002587	Catalytic dyad [active]
634457002588	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
634457002589	Peptidase family M23; Region: Peptidase_M23; pfam01551
634457002590	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
634457002591	phosphoglyceromutase; Provisional; Region: PRK05434
634457002592	threonine dehydratase; Provisional; Region: PRK07334
634457002593	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
634457002594	tetramer interface [polypeptide binding]; other site
634457002595	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457002596	catalytic residue [active]
634457002597	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
634457002598	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
634457002599	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
634457002600	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
634457002601	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
634457002602	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634457002603	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
634457002604	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
634457002605	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634457002606	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634457002607	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
634457002608	IMP binding site; other site
634457002609	dimer interface [polypeptide binding]; other site
634457002610	partial ornithine binding site; other site
634457002611	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
634457002612	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
634457002613	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
634457002614	catalytic site [active]
634457002615	subunit interface [polypeptide binding]; other site
634457002616	Yqey-like protein; Region: YqeY; pfam09424
634457002617	DNA primase; Validated; Region: dnaG; PRK05667
634457002618	CHC2 zinc finger; Region: zf-CHC2; pfam01807
634457002619	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
634457002620	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
634457002621	active site
634457002622	metal binding site [ion binding]; metal-binding site
634457002623	interdomain interaction site; other site
634457002624	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
634457002625	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
634457002626	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
634457002627	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
634457002628	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634457002629	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
634457002630	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634457002631	DNA binding residues [nucleotide binding]
634457002632	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
634457002633	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
634457002634	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
634457002635	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
634457002636	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
634457002637	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
634457002638	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
634457002639	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
634457002640	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457002641	S-adenosylmethionine binding site [chemical binding]; other site
634457002642	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
634457002643	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
634457002644	SurA N-terminal domain; Region: SurA_N; pfam09312
634457002645	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
634457002646	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
634457002647	OstA-like protein; Region: OstA; cl00844
634457002648	Organic solvent tolerance protein; Region: OstA_C; pfam04453
634457002649	Predicted permeases [General function prediction only]; Region: COG0795
634457002650	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634457002651	Predicted permeases [General function prediction only]; Region: COG0795
634457002652	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634457002653	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
634457002654	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634457002655	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457002656	Walker A/P-loop; other site
634457002657	ATP binding site [chemical binding]; other site
634457002658	Q-loop/lid; other site
634457002659	ABC transporter signature motif; other site
634457002660	Walker B; other site
634457002661	D-loop; other site
634457002662	H-loop/switch region; other site
634457002663	Transcriptional regulators [Transcription]; Region: GntR; COG1802
634457002664	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634457002665	DNA-binding site [nucleotide binding]; DNA binding site
634457002666	FCD domain; Region: FCD; pfam07729
634457002667	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
634457002668	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
634457002669	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
634457002670	Switch I; other site
634457002671	Switch II; other site
634457002672	septum formation inhibitor; Reviewed; Region: minC; PRK05177
634457002673	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
634457002674	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
634457002675	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634457002676	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
634457002677	C-terminal domain interface [polypeptide binding]; other site
634457002678	GSH binding site (G-site) [chemical binding]; other site
634457002679	dimer interface [polypeptide binding]; other site
634457002680	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
634457002681	N-terminal domain interface [polypeptide binding]; other site
634457002682	dimer interface [polypeptide binding]; other site
634457002683	substrate binding pocket (H-site) [chemical binding]; other site
634457002684	Predicted flavoproteins [General function prediction only]; Region: COG2081
634457002685	Predicted methyltransferases [General function prediction only]; Region: COG0313
634457002686	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
634457002687	putative SAM binding site [chemical binding]; other site
634457002688	putative homodimer interface [polypeptide binding]; other site
634457002689	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
634457002690	putative ligand binding site [chemical binding]; other site
634457002691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634457002692	TPR motif; other site
634457002693	TPR repeat; Region: TPR_11; pfam13414
634457002694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634457002695	TPR motif; other site
634457002696	binding surface
634457002697	TPR repeat; Region: TPR_11; pfam13414
634457002698	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
634457002699	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
634457002700	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
634457002701	S-formylglutathione hydrolase; Region: PLN02442
634457002702	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
634457002703	putative active site [active]
634457002704	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
634457002705	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
634457002706	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
634457002707	Walker A/P-loop; other site
634457002708	ATP binding site [chemical binding]; other site
634457002709	Q-loop/lid; other site
634457002710	ABC transporter signature motif; other site
634457002711	Walker B; other site
634457002712	D-loop; other site
634457002713	H-loop/switch region; other site
634457002714	zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717
634457002715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457002716	active site
634457002717	phosphorylation site [posttranslational modification]
634457002718	intermolecular recognition site; other site
634457002719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457002720	active site
634457002721	phosphorylation site [posttranslational modification]
634457002722	intermolecular recognition site; other site
634457002723	dimerization interface [polypeptide binding]; other site
634457002724	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
634457002725	dimer interface [polypeptide binding]; other site
634457002726	phosphorylation site [posttranslational modification]
634457002727	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457002728	ATP binding site [chemical binding]; other site
634457002729	Mg2+ binding site [ion binding]; other site
634457002730	G-X-G motif; other site
634457002731	Response regulator receiver domain; Region: Response_reg; pfam00072
634457002732	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457002733	active site
634457002734	phosphorylation site [posttranslational modification]
634457002735	intermolecular recognition site; other site
634457002736	dimerization interface [polypeptide binding]; other site
634457002737	PAS fold; Region: PAS_4; pfam08448
634457002738	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634457002739	dimer interface [polypeptide binding]; other site
634457002740	phosphorylation site [posttranslational modification]
634457002741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457002742	ATP binding site [chemical binding]; other site
634457002743	Mg2+ binding site [ion binding]; other site
634457002744	G-X-G motif; other site
634457002745	Response regulator receiver domain; Region: Response_reg; pfam00072
634457002746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457002747	active site
634457002748	phosphorylation site [posttranslational modification]
634457002749	intermolecular recognition site; other site
634457002750	dimerization interface [polypeptide binding]; other site
634457002751	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
634457002752	active site
634457002753	HslU subunit interaction site [polypeptide binding]; other site
634457002754	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
634457002755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457002756	Walker A motif; other site
634457002757	ATP binding site [chemical binding]; other site
634457002758	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
634457002759	Walker B motif; other site
634457002760	arginine finger; other site
634457002761	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
634457002762	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
634457002763	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
634457002764	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634457002765	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634457002766	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634457002767	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
634457002768	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634457002769	catalytic loop [active]
634457002770	iron binding site [ion binding]; other site
634457002771	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634457002772	Cytochrome c; Region: Cytochrom_C; pfam00034
634457002773	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634457002774	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634457002775	Cytochrome c; Region: Cytochrom_C; pfam00034
634457002776	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
634457002777	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
634457002778	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
634457002779	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
634457002780	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
634457002781	23S rRNA binding site [nucleotide binding]; other site
634457002782	L21 binding site [polypeptide binding]; other site
634457002783	L13 binding site [polypeptide binding]; other site
634457002784	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
634457002785	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
634457002786	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
634457002787	dimer interface [polypeptide binding]; other site
634457002788	motif 1; other site
634457002789	active site
634457002790	motif 2; other site
634457002791	motif 3; other site
634457002792	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
634457002793	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
634457002794	putative tRNA-binding site [nucleotide binding]; other site
634457002795	B3/4 domain; Region: B3_4; pfam03483
634457002796	tRNA synthetase B5 domain; Region: B5; smart00874
634457002797	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
634457002798	motif 1; other site
634457002799	dimer interface [polypeptide binding]; other site
634457002800	motif 3; other site
634457002801	motif 2; other site
634457002802	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
634457002803	PBP superfamily domain; Region: PBP_like_2; cl17296
634457002804	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
634457002805	peptide binding site [polypeptide binding]; other site
634457002806	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
634457002807	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634457002808	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
634457002809	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
634457002810	ligand binding site [chemical binding]; other site
634457002811	flexible hinge region; other site
634457002812	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
634457002813	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
634457002814	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
634457002815	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634457002816	RNA binding surface [nucleotide binding]; other site
634457002817	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
634457002818	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
634457002819	G1 box; other site
634457002820	putative GEF interaction site [polypeptide binding]; other site
634457002821	GTP/Mg2+ binding site [chemical binding]; other site
634457002822	Switch I region; other site
634457002823	G2 box; other site
634457002824	G3 box; other site
634457002825	Switch II region; other site
634457002826	G4 box; other site
634457002827	G5 box; other site
634457002828	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
634457002829	hypothetical protein; Provisional; Region: PRK08999
634457002830	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
634457002831	tartrate dehydrogenase; Region: TTC; TIGR02089
634457002832	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
634457002833	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
634457002834	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
634457002835	active site
634457002836	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
634457002837	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457002838	S-adenosylmethionine binding site [chemical binding]; other site
634457002839	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
634457002840	Part of AAA domain; Region: AAA_19; pfam13245
634457002841	Family description; Region: UvrD_C_2; pfam13538
634457002842	DNA repair protein radc; Region: radc; TIGR00608
634457002843	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
634457002844	DNA repair protein radc; Region: radc; TIGR00608
634457002845	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
634457002846	MPN+ (JAMM) motif; other site
634457002847	Zinc-binding site [ion binding]; other site
634457002848	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
634457002849	ATP-grasp domain; Region: ATP-grasp; pfam02222
634457002850	AIR carboxylase; Region: AIRC; pfam00731
634457002851	Protein of unknown function (DUF465); Region: DUF465; cl01070
634457002852	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
634457002853	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
634457002854	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
634457002855	putative dimer interface [polypeptide binding]; other site
634457002856	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
634457002857	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
634457002858	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
634457002859	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
634457002860	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
634457002861	Protein export membrane protein; Region: SecD_SecF; pfam02355
634457002862	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
634457002863	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
634457002864	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
634457002865	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
634457002866	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
634457002867	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
634457002868	Class I ribonucleotide reductase; Region: RNR_I; cd01679
634457002869	active site
634457002870	dimer interface [polypeptide binding]; other site
634457002871	catalytic residues [active]
634457002872	effector binding site; other site
634457002873	R2 peptide binding site; other site
634457002874	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
634457002875	dimer interface [polypeptide binding]; other site
634457002876	putative radical transfer pathway; other site
634457002877	diiron center [ion binding]; other site
634457002878	tyrosyl radical; other site
634457002879	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
634457002880	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
634457002881	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
634457002882	substrate binding pocket [chemical binding]; other site
634457002883	chain length determination region; other site
634457002884	substrate-Mg2+ binding site; other site
634457002885	catalytic residues [active]
634457002886	aspartate-rich region 1; other site
634457002887	active site lid residues [active]
634457002888	aspartate-rich region 2; other site
634457002889	glutamate racemase; Provisional; Region: PRK00865
634457002890	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634457002891	active site
634457002892	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
634457002893	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
634457002894	dimer interface [polypeptide binding]; other site
634457002895	active site
634457002896	citrylCoA binding site [chemical binding]; other site
634457002897	NADH binding [chemical binding]; other site
634457002898	cationic pore residues; other site
634457002899	oxalacetate/citrate binding site [chemical binding]; other site
634457002900	coenzyme A binding site [chemical binding]; other site
634457002901	catalytic triad [active]
634457002902	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634457002903	catalytic core [active]
634457002904	chorismate mutase; Provisional; Region: PRK09239
634457002905	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
634457002906	active site
634457002907	metal binding site [ion binding]; metal-binding site
634457002908	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
634457002909	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
634457002910	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
634457002911	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
634457002912	AAA domain; Region: AAA_23; pfam13476
634457002913	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
634457002914	Walker A/P-loop; other site
634457002915	ATP binding site [chemical binding]; other site
634457002916	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
634457002917	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
634457002918	ABC transporter signature motif; other site
634457002919	Walker B; other site
634457002920	D-loop; other site
634457002921	H-loop/switch region; other site
634457002922	Thioredoxin; Region: Thioredoxin_4; pfam13462
634457002923	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
634457002924	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
634457002925	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
634457002926	Transporter associated domain; Region: CorC_HlyC; smart01091
634457002927	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
634457002928	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
634457002929	PhoH-like protein; Region: PhoH; pfam02562
634457002930	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
634457002931	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
634457002932	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457002933	FeS/SAM binding site; other site
634457002934	TRAM domain; Region: TRAM; cl01282
634457002935	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
634457002936	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
634457002937	putative acyl-acceptor binding pocket; other site
634457002938	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
634457002939	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634457002940	Surface antigen; Region: Bac_surface_Ag; pfam01103
634457002941	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
634457002942	Family of unknown function (DUF490); Region: DUF490; pfam04357
634457002943	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
634457002944	putative catalytic site [active]
634457002945	putative phosphate binding site [ion binding]; other site
634457002946	active site
634457002947	metal binding site A [ion binding]; metal-binding site
634457002948	DNA binding site [nucleotide binding]
634457002949	putative AP binding site [nucleotide binding]; other site
634457002950	putative metal binding site B [ion binding]; other site
634457002951	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
634457002952	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
634457002953	active site
634457002954	dimer interface [polypeptide binding]; other site
634457002955	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
634457002956	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
634457002957	GIY-YIG motif/motif A; other site
634457002958	active site
634457002959	catalytic site [active]
634457002960	putative DNA binding site [nucleotide binding]; other site
634457002961	metal binding site [ion binding]; metal-binding site
634457002962	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
634457002963	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
634457002964	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
634457002965	MoaE interaction surface [polypeptide binding]; other site
634457002966	MoeB interaction surface [polypeptide binding]; other site
634457002967	thiocarboxylated glycine; other site
634457002968	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
634457002969	MoaE homodimer interface [polypeptide binding]; other site
634457002970	MoaD interaction [polypeptide binding]; other site
634457002971	active site residues [active]
634457002972	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
634457002973	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634457002974	inhibitor-cofactor binding pocket; inhibition site
634457002975	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457002976	catalytic residue [active]
634457002977	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
634457002978	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
634457002979	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634457002980	catalytic residue [active]
634457002981	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634457002982	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
634457002983	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457002984	S-adenosylmethionine binding site [chemical binding]; other site
634457002985	AAA domain; Region: AAA_26; pfam13500
634457002986	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
634457002987	LexA repressor; Validated; Region: PRK00215
634457002988	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
634457002989	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634457002990	Catalytic site [active]
634457002991	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
634457002992	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
634457002993	dimer interface [polypeptide binding]; other site
634457002994	putative functional site; other site
634457002995	putative MPT binding site; other site
634457002996	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
634457002997	Septum formation initiator; Region: DivIC; cl17659
634457002998	enolase; Provisional; Region: eno; PRK00077
634457002999	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
634457003000	dimer interface [polypeptide binding]; other site
634457003001	metal binding site [ion binding]; metal-binding site
634457003002	substrate binding pocket [chemical binding]; other site
634457003003	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
634457003004	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
634457003005	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
634457003006	thiS-thiF/thiG interaction site; other site
634457003007	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
634457003008	ThiS interaction site; other site
634457003009	putative active site [active]
634457003010	tetramer interface [polypeptide binding]; other site
634457003011	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
634457003012	thiamine phosphate binding site [chemical binding]; other site
634457003013	active site
634457003014	pyrophosphate binding site [ion binding]; other site
634457003015	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
634457003016	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
634457003017	generic binding surface II; other site
634457003018	ssDNA binding site; other site
634457003019	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634457003020	ATP binding site [chemical binding]; other site
634457003021	putative Mg++ binding site [ion binding]; other site
634457003022	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634457003023	nucleotide binding region [chemical binding]; other site
634457003024	ATP-binding site [chemical binding]; other site
634457003025	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
634457003026	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
634457003027	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
634457003028	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634457003029	ATP binding site [chemical binding]; other site
634457003030	putative Mg++ binding site [ion binding]; other site
634457003031	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634457003032	nucleotide binding region [chemical binding]; other site
634457003033	ATP-binding site [chemical binding]; other site
634457003034	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
634457003035	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
634457003036	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
634457003037	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
634457003038	tyrosine decarboxylase; Region: PLN02880
634457003039	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
634457003040	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457003041	catalytic residue [active]
634457003042	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
634457003043	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
634457003044	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
634457003045	metal ion-dependent adhesion site (MIDAS); other site
634457003046	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
634457003047	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
634457003048	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
634457003049	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634457003050	HSP70 interaction site [polypeptide binding]; other site
634457003051	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
634457003052	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
634457003053	lipoate-protein ligase B; Provisional; Region: PRK14341
634457003054	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
634457003055	active site
634457003056	tetramer interface; other site
634457003057	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
634457003058	active site
634457003059	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
634457003060	substrate binding site [chemical binding]; other site
634457003061	metal binding site [ion binding]; metal-binding site
634457003062	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
634457003063	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457003064	FeS/SAM binding site; other site
634457003065	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
634457003066	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457003067	S-adenosylmethionine binding site [chemical binding]; other site
634457003068	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
634457003069	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634457003070	active site
634457003071	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
634457003072	GSH binding site [chemical binding]; other site
634457003073	catalytic residues [active]
634457003074	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
634457003075	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
634457003076	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
634457003077	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
634457003078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457003079	S-adenosylmethionine binding site [chemical binding]; other site
634457003080	aspartate kinase; Reviewed; Region: PRK06635
634457003081	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
634457003082	putative nucleotide binding site [chemical binding]; other site
634457003083	putative catalytic residues [active]
634457003084	putative Mg ion binding site [ion binding]; other site
634457003085	putative aspartate binding site [chemical binding]; other site
634457003086	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
634457003087	putative allosteric regulatory site; other site
634457003088	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
634457003089	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
634457003090	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
634457003091	FMN binding site [chemical binding]; other site
634457003092	substrate binding site [chemical binding]; other site
634457003093	putative catalytic residue [active]
634457003094	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
634457003095	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634457003096	non-specific DNA binding site [nucleotide binding]; other site
634457003097	salt bridge; other site
634457003098	sequence-specific DNA binding site [nucleotide binding]; other site
634457003099	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
634457003100	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
634457003101	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
634457003102	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
634457003103	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
634457003104	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
634457003105	dimer interface [polypeptide binding]; other site
634457003106	motif 1; other site
634457003107	active site
634457003108	motif 2; other site
634457003109	motif 3; other site
634457003110	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
634457003111	anticodon binding site; other site
634457003112	peptide chain release factor 1; Validated; Region: prfA; PRK00591
634457003113	PCRF domain; Region: PCRF; pfam03462
634457003114	RF-1 domain; Region: RF-1; pfam00472
634457003115	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
634457003116	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
634457003117	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
634457003118	mce related protein; Region: MCE; pfam02470
634457003119	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
634457003120	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
634457003121	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634457003122	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
634457003123	Transglycosylase SLT domain; Region: SLT_2; pfam13406
634457003124	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634457003125	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634457003126	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
634457003127	Sporulation related domain; Region: SPOR; cl10051
634457003128	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
634457003129	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
634457003130	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
634457003131	thymidylate kinase; Validated; Region: tmk; PRK00698
634457003132	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
634457003133	TMP-binding site; other site
634457003134	ATP-binding site [chemical binding]; other site
634457003135	DNA polymerase III subunit delta'; Validated; Region: PRK07471
634457003136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457003137	Walker A motif; other site
634457003138	ATP binding site [chemical binding]; other site
634457003139	Walker B motif; other site
634457003140	arginine finger; other site
634457003141	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
634457003142	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
634457003143	active site
634457003144	HIGH motif; other site
634457003145	KMSKS motif; other site
634457003146	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
634457003147	tRNA binding surface [nucleotide binding]; other site
634457003148	anticodon binding site; other site
634457003149	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
634457003150	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
634457003151	active site
634457003152	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
634457003153	putative hydrolase; Provisional; Region: PRK02113
634457003154	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
634457003155	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
634457003156	Ligand Binding Site [chemical binding]; other site
634457003157	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
634457003158	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
634457003159	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
634457003160	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
634457003161	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
634457003162	NAD binding site [chemical binding]; other site
634457003163	homotetramer interface [polypeptide binding]; other site
634457003164	homodimer interface [polypeptide binding]; other site
634457003165	substrate binding site [chemical binding]; other site
634457003166	active site
634457003167	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
634457003168	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
634457003169	Tetramer interface [polypeptide binding]; other site
634457003170	active site
634457003171	FMN-binding site [chemical binding]; other site
634457003172	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
634457003173	malate:quinone oxidoreductase; Validated; Region: PRK05257
634457003174	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
634457003175	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
634457003176	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
634457003177	Ligand Binding Site [chemical binding]; other site
634457003178	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
634457003179	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
634457003180	biotin synthase; Region: bioB; TIGR00433
634457003181	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457003182	FeS/SAM binding site; other site
634457003183	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
634457003184	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
634457003185	Domain of unknown function (DUF333); Region: DUF333; pfam03891
634457003186	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
634457003187	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
634457003188	Active Sites [active]
634457003189	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
634457003190	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
634457003191	Active Sites [active]
634457003192	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
634457003193	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
634457003194	G1 box; other site
634457003195	GTP/Mg2+ binding site [chemical binding]; other site
634457003196	G2 box; other site
634457003197	Switch I region; other site
634457003198	G3 box; other site
634457003199	Switch II region; other site
634457003200	G4 box; other site
634457003201	G5 box; other site
634457003202	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
634457003203	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
634457003204	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
634457003205	ligand-binding site [chemical binding]; other site
634457003206	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
634457003207	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
634457003208	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634457003209	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634457003210	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
634457003211	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
634457003212	putative acyl-acceptor binding pocket; other site
634457003213	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
634457003214	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
634457003215	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
634457003216	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
634457003217	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
634457003218	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
634457003219	putative acyl-acceptor binding pocket; other site
634457003220	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634457003221	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
634457003222	active site
634457003223	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
634457003224	putative amphipathic alpha helix; other site
634457003225	YceG-like family; Region: YceG; pfam02618
634457003226	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
634457003227	dimerization interface [polypeptide binding]; other site
634457003228	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
634457003229	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
634457003230	dimer interface [polypeptide binding]; other site
634457003231	active site
634457003232	acyl carrier protein; Provisional; Region: acpP; PRK00982
634457003233	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457003234	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
634457003235	NAD(P) binding site [chemical binding]; other site
634457003236	active site
634457003237	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
634457003238	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
634457003239	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
634457003240	putative active site [active]
634457003241	Methyltransferase domain; Region: Methyltransf_31; pfam13847
634457003242	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457003243	S-adenosylmethionine binding site [chemical binding]; other site
634457003244	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
634457003245	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
634457003246	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634457003247	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634457003248	catalytic residues [active]
634457003249	catalytic nucleophile [active]
634457003250	Presynaptic Site I dimer interface [polypeptide binding]; other site
634457003251	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634457003252	Synaptic Flat tetramer interface [polypeptide binding]; other site
634457003253	Synaptic Site I dimer interface [polypeptide binding]; other site
634457003254	DNA binding site [nucleotide binding]
634457003255	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634457003256	DNA-binding interface [nucleotide binding]; DNA binding site
634457003257	Winged helix-turn helix; Region: HTH_29; pfam13551
634457003258	Helix-turn-helix domain; Region: HTH_28; pfam13518
634457003259	Homeodomain-like domain; Region: HTH_32; pfam13565
634457003260	Integrase core domain; Region: rve; pfam00665
634457003261	Integrase core domain; Region: rve_3; cl15866
634457003262	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
634457003263	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
634457003264	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634457003265	DNA-binding site [nucleotide binding]; DNA binding site
634457003266	RNA-binding motif; other site
634457003267	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634457003268	DNA-binding site [nucleotide binding]; DNA binding site
634457003269	RNA-binding motif; other site
634457003270	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
634457003271	SmpB-tmRNA interface; other site
634457003272	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
634457003273	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
634457003274	dimer interface [polypeptide binding]; other site
634457003275	active site
634457003276	catalytic residue [active]
634457003277	prephenate dehydratase; Provisional; Region: PRK11899
634457003278	Prephenate dehydratase; Region: PDT; pfam00800
634457003279	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
634457003280	putative L-Phe binding site [chemical binding]; other site
634457003281	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
634457003282	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
634457003283	Ligand binding site; other site
634457003284	oligomer interface; other site
634457003285	Cytochrome c; Region: Cytochrom_C; cl11414
634457003286	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634457003287	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
634457003288	active site
634457003289	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
634457003290	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
634457003291	ligand binding site [chemical binding]; other site
634457003292	NAD binding site [chemical binding]; other site
634457003293	tetramer interface [polypeptide binding]; other site
634457003294	catalytic site [active]
634457003295	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
634457003296	L-serine binding site [chemical binding]; other site
634457003297	ACT domain interface; other site
634457003298	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
634457003299	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
634457003300	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
634457003301	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
634457003302	cystathionine beta-lyase; Provisional; Region: PRK05967
634457003303	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
634457003304	homodimer interface [polypeptide binding]; other site
634457003305	substrate-cofactor binding pocket; other site
634457003306	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457003307	catalytic residue [active]
634457003308	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
634457003309	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
634457003310	active site residue [active]
634457003311	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
634457003312	active site residue [active]
634457003313	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634457003314	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634457003315	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
634457003316	putative catalytic site [active]
634457003317	putative metal binding site [ion binding]; other site
634457003318	putative phosphate binding site [ion binding]; other site
634457003319	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
634457003320	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
634457003321	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
634457003322	putative active site [active]
634457003323	catalytic site [active]
634457003324	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
634457003325	putative active site [active]
634457003326	catalytic site [active]
634457003327	hypothetical protein; Reviewed; Region: PRK12497
634457003328	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
634457003329	putative GSH binding site [chemical binding]; other site
634457003330	catalytic residues [active]
634457003331	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
634457003332	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
634457003333	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
634457003334	dimerization interface [polypeptide binding]; other site
634457003335	ATP binding site [chemical binding]; other site
634457003336	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
634457003337	dimerization interface [polypeptide binding]; other site
634457003338	ATP binding site [chemical binding]; other site
634457003339	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
634457003340	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
634457003341	putative active site [active]
634457003342	catalytic triad [active]
634457003343	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
634457003344	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
634457003345	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
634457003346	ATP binding site [chemical binding]; other site
634457003347	active site
634457003348	substrate binding site [chemical binding]; other site
634457003349	adenylosuccinate lyase; Provisional; Region: PRK07492
634457003350	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
634457003351	tetramer interface [polypeptide binding]; other site
634457003352	active site
634457003353	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
634457003354	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
634457003355	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634457003356	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634457003357	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634457003358	catalytic residue [active]
634457003359	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
634457003360	tetramer interfaces [polypeptide binding]; other site
634457003361	binuclear metal-binding site [ion binding]; other site
634457003362	Competence-damaged protein; Region: CinA; pfam02464
634457003363	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
634457003364	putative coenzyme Q binding site [chemical binding]; other site
634457003365	lipoyl synthase; Provisional; Region: PRK05481
634457003366	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457003367	FeS/SAM binding site; other site
634457003368	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
634457003369	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634457003370	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
634457003371	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634457003372	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
634457003373	E3 interaction surface; other site
634457003374	lipoyl attachment site [posttranslational modification]; other site
634457003375	e3 binding domain; Region: E3_binding; pfam02817
634457003376	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
634457003377	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
634457003378	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634457003379	E3 interaction surface; other site
634457003380	lipoyl attachment site [posttranslational modification]; other site
634457003381	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
634457003382	alpha subunit interface [polypeptide binding]; other site
634457003383	TPP binding site [chemical binding]; other site
634457003384	heterodimer interface [polypeptide binding]; other site
634457003385	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634457003386	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
634457003387	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
634457003388	tetramer interface [polypeptide binding]; other site
634457003389	TPP-binding site [chemical binding]; other site
634457003390	heterodimer interface [polypeptide binding]; other site
634457003391	phosphorylation loop region [posttranslational modification]
634457003392	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
634457003393	trimer interface [polypeptide binding]; other site
634457003394	dimer interface [polypeptide binding]; other site
634457003395	putative active site [active]
634457003396	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
634457003397	active site
634457003398	ribulose/triose binding site [chemical binding]; other site
634457003399	phosphate binding site [ion binding]; other site
634457003400	substrate (anthranilate) binding pocket [chemical binding]; other site
634457003401	product (indole) binding pocket [chemical binding]; other site
634457003402	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
634457003403	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
634457003404	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
634457003405	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
634457003406	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
634457003407	glutamine binding [chemical binding]; other site
634457003408	catalytic triad [active]
634457003409	anthranilate synthase component I; Provisional; Region: PRK13573
634457003410	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
634457003411	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
634457003412	SurA N-terminal domain; Region: SurA_N_3; cl07813
634457003413	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
634457003414	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
634457003415	triosephosphate isomerase; Provisional; Region: PRK14565
634457003416	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
634457003417	substrate binding site [chemical binding]; other site
634457003418	dimer interface [polypeptide binding]; other site
634457003419	catalytic triad [active]
634457003420	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
634457003421	CTP synthetase; Validated; Region: pyrG; PRK05380
634457003422	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
634457003423	Catalytic site [active]
634457003424	active site
634457003425	UTP binding site [chemical binding]; other site
634457003426	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
634457003427	active site
634457003428	putative oxyanion hole; other site
634457003429	catalytic triad [active]
634457003430	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
634457003431	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
634457003432	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
634457003433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457003434	ATP binding site [chemical binding]; other site
634457003435	Mg2+ binding site [ion binding]; other site
634457003436	G-X-G motif; other site
634457003437	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
634457003438	anchoring element; other site
634457003439	dimer interface [polypeptide binding]; other site
634457003440	ATP binding site [chemical binding]; other site
634457003441	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
634457003442	active site
634457003443	putative metal-binding site [ion binding]; other site
634457003444	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
634457003445	recombination protein F; Reviewed; Region: recF; PRK00064
634457003446	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457003447	Walker A/P-loop; other site
634457003448	ATP binding site [chemical binding]; other site
634457003449	Q-loop/lid; other site
634457003450	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457003451	ABC transporter signature motif; other site
634457003452	Walker B; other site
634457003453	D-loop; other site
634457003454	H-loop/switch region; other site
634457003455	DNA polymerase III subunit beta; Validated; Region: PRK05643
634457003456	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
634457003457	putative DNA binding surface [nucleotide binding]; other site
634457003458	dimer interface [polypeptide binding]; other site
634457003459	beta-clamp/clamp loader binding surface; other site
634457003460	beta-clamp/translesion DNA polymerase binding surface; other site
634457003461	DnaA N-terminal domain; Region: DnaA_N; pfam11638
634457003462	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
634457003463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457003464	Walker A motif; other site
634457003465	ATP binding site [chemical binding]; other site
634457003466	Walker B motif; other site
634457003467	arginine finger; other site
634457003468	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
634457003469	DnaA box-binding interface [nucleotide binding]; other site
634457003470	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
634457003471	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
634457003472	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
634457003473	DNA binding site [nucleotide binding]
634457003474	catalytic residue [active]
634457003475	H2TH interface [polypeptide binding]; other site
634457003476	putative catalytic residues [active]
634457003477	turnover-facilitating residue; other site
634457003478	intercalation triad [nucleotide binding]; other site
634457003479	8OG recognition residue [nucleotide binding]; other site
634457003480	putative reading head residues; other site
634457003481	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
634457003482	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
634457003483	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457003484	S-adenosylmethionine binding site [chemical binding]; other site
634457003485	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
634457003486	Flavoprotein; Region: Flavoprotein; pfam02441
634457003487	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
634457003488	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
634457003489	trimer interface [polypeptide binding]; other site
634457003490	active site
634457003491	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
634457003492	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457003493	dimer interface [polypeptide binding]; other site
634457003494	conserved gate region; other site
634457003495	putative PBP binding loops; other site
634457003496	ABC-ATPase subunit interface; other site
634457003497	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634457003498	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634457003499	Walker A/P-loop; other site
634457003500	ATP binding site [chemical binding]; other site
634457003501	Q-loop/lid; other site
634457003502	ABC transporter signature motif; other site
634457003503	Walker B; other site
634457003504	D-loop; other site
634457003505	H-loop/switch region; other site
634457003506	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
634457003507	methionine sulfoxide reductase A; Provisional; Region: PRK14054
634457003508	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
634457003509	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
634457003510	HIGH motif; other site
634457003511	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
634457003512	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
634457003513	active site
634457003514	KMSKS motif; other site
634457003515	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
634457003516	tRNA binding surface [nucleotide binding]; other site
634457003517	anticodon binding site; other site
634457003518	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
634457003519	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
634457003520	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
634457003521	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
634457003522	Hint domain; Region: Hint_2; pfam13403
634457003523	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
634457003524	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457003525	NAD(P) binding site [chemical binding]; other site
634457003526	active site
634457003527	thiamine monophosphate kinase; Provisional; Region: PRK05731
634457003528	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
634457003529	ATP binding site [chemical binding]; other site
634457003530	dimerization interface [polypeptide binding]; other site
634457003531	transcription antitermination factor NusB; Region: nusB; TIGR01951
634457003532	putative RNA binding site [nucleotide binding]; other site
634457003533	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
634457003534	ATP cone domain; Region: ATP-cone; pfam03477
634457003535	Protein of unknown function (DUF461); Region: DUF461; pfam04314
634457003536	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
634457003537	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
634457003538	N- and C-terminal domain interface [polypeptide binding]; other site
634457003539	active site
634457003540	MgATP binding site [chemical binding]; other site
634457003541	catalytic site [active]
634457003542	metal binding site [ion binding]; metal-binding site
634457003543	glycerol binding site [chemical binding]; other site
634457003544	homotetramer interface [polypeptide binding]; other site
634457003545	homodimer interface [polypeptide binding]; other site
634457003546	FBP binding site [chemical binding]; other site
634457003547	protein IIAGlc interface [polypeptide binding]; other site
634457003548	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
634457003549	amphipathic channel; other site
634457003550	Asn-Pro-Ala signature motifs; other site
634457003551	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
634457003552	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
634457003553	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
634457003554	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
634457003555	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
634457003556	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634457003557	ATP binding site [chemical binding]; other site
634457003558	putative Mg++ binding site [ion binding]; other site
634457003559	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634457003560	nucleotide binding region [chemical binding]; other site
634457003561	ATP-binding site [chemical binding]; other site
634457003562	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
634457003563	HRDC domain; Region: HRDC; pfam00570
634457003564	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634457003565	ligand binding site [chemical binding]; other site
634457003566	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
634457003567	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457003568	Walker A/P-loop; other site
634457003569	ATP binding site [chemical binding]; other site
634457003570	Q-loop/lid; other site
634457003571	ABC transporter signature motif; other site
634457003572	Walker B; other site
634457003573	D-loop; other site
634457003574	H-loop/switch region; other site
634457003575	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
634457003576	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457003577	Walker A/P-loop; other site
634457003578	ATP binding site [chemical binding]; other site
634457003579	Q-loop/lid; other site
634457003580	ABC transporter signature motif; other site
634457003581	Walker B; other site
634457003582	D-loop; other site
634457003583	H-loop/switch region; other site
634457003584	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
634457003585	Histidine kinase; Region: HisKA_2; pfam07568
634457003586	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457003587	ATP binding site [chemical binding]; other site
634457003588	Mg2+ binding site [ion binding]; other site
634457003589	G-X-G motif; other site
634457003590	RNA polymerase sigma factor; Provisional; Region: PRK12547
634457003591	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634457003592	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634457003593	DNA binding residues [nucleotide binding]
634457003594	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634457003595	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634457003596	DNA binding residues [nucleotide binding]
634457003597	two-component response regulator; Provisional; Region: PRK09191
634457003598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457003599	active site
634457003600	phosphorylation site [posttranslational modification]
634457003601	intermolecular recognition site; other site
634457003602	dimerization interface [polypeptide binding]; other site
634457003603	ABC transporter ATPase component; Reviewed; Region: PRK11147
634457003604	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634457003605	ABC transporter; Region: ABC_tran_2; pfam12848
634457003606	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634457003607	trehalase; Provisional; Region: treF; PRK13270
634457003608	Trehalase; Region: Trehalase; cl17346
634457003609	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
634457003610	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
634457003611	substrate binding site [chemical binding]; other site
634457003612	catalytic Zn binding site [ion binding]; other site
634457003613	NAD binding site [chemical binding]; other site
634457003614	structural Zn binding site [ion binding]; other site
634457003615	dimer interface [polypeptide binding]; other site
634457003616	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
634457003617	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
634457003618	PhnA protein; Region: PhnA; pfam03831
634457003619	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
634457003620	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
634457003621	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
634457003622	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
634457003623	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
634457003624	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
634457003625	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
634457003626	amidohydrolase; Provisional; Region: PRK12393
634457003627	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
634457003628	active site
634457003629	putative substrate binding pocket [chemical binding]; other site
634457003630	NMT1/THI5 like; Region: NMT1; pfam09084
634457003631	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
634457003632	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634457003633	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634457003634	Walker A/P-loop; other site
634457003635	ATP binding site [chemical binding]; other site
634457003636	Q-loop/lid; other site
634457003637	ABC transporter signature motif; other site
634457003638	Walker B; other site
634457003639	D-loop; other site
634457003640	H-loop/switch region; other site
634457003641	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634457003642	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457003643	dimer interface [polypeptide binding]; other site
634457003644	ABC-ATPase subunit interface; other site
634457003645	putative PBP binding loops; other site
634457003646	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
634457003647	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
634457003648	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
634457003649	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
634457003650	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
634457003651	active site
634457003652	putative substrate binding pocket [chemical binding]; other site
634457003653	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634457003654	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457003655	allantoate amidohydrolase; Reviewed; Region: PRK09290
634457003656	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
634457003657	active site
634457003658	metal binding site [ion binding]; metal-binding site
634457003659	dimer interface [polypeptide binding]; other site
634457003660	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
634457003661	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634457003662	catalytic residue [active]
634457003663	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
634457003664	SnoaL-like domain; Region: SnoaL_3; pfam13474
634457003665	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
634457003666	amidase; Provisional; Region: PRK09201
634457003667	Amidase; Region: Amidase; pfam01425
634457003668	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
634457003669	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
634457003670	XdhC Rossmann domain; Region: XdhC_C; pfam13478
634457003671	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
634457003672	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634457003673	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634457003674	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
634457003675	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634457003676	catalytic loop [active]
634457003677	iron binding site [ion binding]; other site
634457003678	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634457003679	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
634457003680	xanthine permease; Region: pbuX; TIGR03173
634457003681	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
634457003682	active site
634457003683	homotetramer interface [polypeptide binding]; other site
634457003684	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
634457003685	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
634457003686	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
634457003687	active site
634457003688	catalytic site [active]
634457003689	tetramer interface [polypeptide binding]; other site
634457003690	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
634457003691	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
634457003692	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457003693	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457003694	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634457003695	dimerization interface [polypeptide binding]; other site
634457003696	guanine deaminase; Provisional; Region: PRK09228
634457003697	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
634457003698	active site
634457003699	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
634457003700	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
634457003701	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634457003702	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634457003703	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634457003704	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634457003705	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
634457003706	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634457003707	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
634457003708	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634457003709	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457003710	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
634457003711	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
634457003712	Walker A/P-loop; other site
634457003713	ATP binding site [chemical binding]; other site
634457003714	Q-loop/lid; other site
634457003715	ABC transporter signature motif; other site
634457003716	Walker B; other site
634457003717	D-loop; other site
634457003718	H-loop/switch region; other site
634457003719	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457003720	Walker A/P-loop; other site
634457003721	ATP binding site [chemical binding]; other site
634457003722	Q-loop/lid; other site
634457003723	ABC transporter signature motif; other site
634457003724	Walker B; other site
634457003725	D-loop; other site
634457003726	H-loop/switch region; other site
634457003727	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
634457003728	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
634457003729	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
634457003730	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
634457003731	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634457003732	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457003733	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457003734	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
634457003735	putative dimerization interface [polypeptide binding]; other site
634457003736	Predicted membrane protein [Function unknown]; Region: COG2855
634457003737	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
634457003738	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
634457003739	Active site cavity [active]
634457003740	catalytic acid [active]
634457003741	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634457003742	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634457003743	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634457003744	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634457003745	WHG domain; Region: WHG; pfam13305
634457003746	Secretory lipase; Region: LIP; pfam03583
634457003747	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
634457003748	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634457003749	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634457003750	NAD(P) binding site [chemical binding]; other site
634457003751	catalytic residues [active]
634457003752	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
634457003753	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
634457003754	FMN binding site [chemical binding]; other site
634457003755	active site
634457003756	substrate binding site [chemical binding]; other site
634457003757	catalytic residue [active]
634457003758	Predicted transcriptional regulators [Transcription]; Region: COG1733
634457003759	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
634457003760	hydroperoxidase II; Provisional; Region: katE; PRK11249
634457003761	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
634457003762	heme binding pocket [chemical binding]; other site
634457003763	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
634457003764	domain interactions; other site
634457003765	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
634457003766	hypothetical protein; Provisional; Region: PRK09256
634457003767	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634457003768	Putative glucoamylase; Region: Glycoamylase; pfam10091
634457003769	Putative glucoamylase; Region: Glycoamylase; pfam10091
634457003770	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
634457003771	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
634457003772	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
634457003773	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
634457003774	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634457003775	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634457003776	active site
634457003777	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
634457003778	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634457003779	Coenzyme A binding pocket [chemical binding]; other site
634457003780	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
634457003781	dimer interface [polypeptide binding]; other site
634457003782	substrate binding site [chemical binding]; other site
634457003783	ATP binding site [chemical binding]; other site
634457003784	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
634457003785	ABC transporter signature motif; other site
634457003786	Walker B; other site
634457003787	D-loop; other site
634457003788	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457003789	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457003790	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
634457003791	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
634457003792	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
634457003793	Protein of unknown function DUF72; Region: DUF72; pfam01904
634457003794	Uncharacterized conserved protein [Function unknown]; Region: COG2135
634457003795	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
634457003796	putative chaperone; Provisional; Region: PRK11678
634457003797	nucleotide binding site [chemical binding]; other site
634457003798	putative NEF/HSP70 interaction site [polypeptide binding]; other site
634457003799	SBD interface [polypeptide binding]; other site
634457003800	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634457003801	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
634457003802	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634457003803	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457003804	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
634457003805	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634457003806	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634457003807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
634457003808	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
634457003809	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
634457003810	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634457003811	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457003812	putative substrate translocation pore; other site
634457003813	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
634457003814	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
634457003815	active site
634457003816	hypothetical protein; Provisional; Region: PRK09945
634457003817	Hint domain; Region: Hint_2; pfam13403
634457003818	SnoaL-like domain; Region: SnoaL_2; pfam12680
634457003819	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
634457003820	Helix-turn-helix domain; Region: HTH_18; pfam12833
634457003821	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634457003822	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
634457003823	putative deacylase active site [active]
634457003824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457003825	putative substrate translocation pore; other site
634457003826	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
634457003827	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
634457003828	metal binding site 2 [ion binding]; metal-binding site
634457003829	putative DNA binding helix; other site
634457003830	metal binding site 1 [ion binding]; metal-binding site
634457003831	dimer interface [polypeptide binding]; other site
634457003832	structural Zn2+ binding site [ion binding]; other site
634457003833	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
634457003834	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634457003835	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634457003836	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
634457003837	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
634457003838	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
634457003839	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457003840	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457003841	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457003842	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
634457003843	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
634457003844	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634457003845	ligand-binding site [chemical binding]; other site
634457003846	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457003847	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457003848	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457003849	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
634457003850	FecR protein; Region: FecR; pfam04773
634457003851	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634457003852	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
634457003853	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
634457003854	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
634457003855	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634457003856	N-terminal plug; other site
634457003857	ligand-binding site [chemical binding]; other site
634457003858	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
634457003859	FecR protein; Region: FecR; pfam04773
634457003860	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457003861	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457003862	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
634457003863	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634457003864	DNA binding residues [nucleotide binding]
634457003865	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
634457003866	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
634457003867	substrate binding pocket [chemical binding]; other site
634457003868	membrane-bound complex binding site; other site
634457003869	hinge residues; other site
634457003870	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634457003871	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634457003872	Walker A/P-loop; other site
634457003873	ATP binding site [chemical binding]; other site
634457003874	Q-loop/lid; other site
634457003875	ABC transporter signature motif; other site
634457003876	Walker B; other site
634457003877	D-loop; other site
634457003878	H-loop/switch region; other site
634457003879	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634457003880	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457003881	dimer interface [polypeptide binding]; other site
634457003882	conserved gate region; other site
634457003883	putative PBP binding loops; other site
634457003884	ABC-ATPase subunit interface; other site
634457003885	Secretory lipase; Region: LIP; pfam03583
634457003886	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
634457003887	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
634457003888	active site
634457003889	iron coordination sites [ion binding]; other site
634457003890	substrate binding pocket [chemical binding]; other site
634457003891	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634457003892	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457003893	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457003894	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457003895	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457003896	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457003897	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
634457003898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457003899	D-galactonate transporter; Region: 2A0114; TIGR00893
634457003900	putative substrate translocation pore; other site
634457003901	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
634457003902	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457003903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457003904	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457003905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457003906	putative substrate translocation pore; other site
634457003907	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
634457003908	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457003909	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
634457003910	putative dimerization interface [polypeptide binding]; other site
634457003911	putative substrate binding pocket [chemical binding]; other site
634457003912	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
634457003913	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
634457003914	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634457003915	Winged helix-turn helix; Region: HTH_29; pfam13551
634457003916	Integrase core domain; Region: rve; pfam00665
634457003917	Integrase core domain; Region: rve_3; pfam13683
634457003918	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634457003919	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634457003920	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457003921	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457003922	LysR substrate binding domain; Region: LysR_substrate; pfam03466
634457003923	dimerization interface [polypeptide binding]; other site
634457003924	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
634457003925	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
634457003926	putative active site [active]
634457003927	metal binding site [ion binding]; metal-binding site
634457003928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457003929	metabolite-proton symporter; Region: 2A0106; TIGR00883
634457003930	putative substrate translocation pore; other site
634457003931	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
634457003932	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
634457003933	tetrameric interface [polypeptide binding]; other site
634457003934	NAD binding site [chemical binding]; other site
634457003935	catalytic residues [active]
634457003936	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
634457003937	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
634457003938	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634457003939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457003940	dimer interface [polypeptide binding]; other site
634457003941	conserved gate region; other site
634457003942	putative PBP binding loops; other site
634457003943	ABC-ATPase subunit interface; other site
634457003944	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634457003945	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634457003946	Walker A/P-loop; other site
634457003947	ATP binding site [chemical binding]; other site
634457003948	Q-loop/lid; other site
634457003949	ABC transporter signature motif; other site
634457003950	Walker B; other site
634457003951	D-loop; other site
634457003952	H-loop/switch region; other site
634457003953	nickel responsive regulator; Provisional; Region: PRK04460
634457003954	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
634457003955	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
634457003956	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
634457003957	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
634457003958	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
634457003959	urea carboxylase; Region: urea_carbox; TIGR02712
634457003960	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634457003961	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634457003962	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
634457003963	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
634457003964	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
634457003965	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
634457003966	carboxyltransferase (CT) interaction site; other site
634457003967	biotinylation site [posttranslational modification]; other site
634457003968	allophanate hydrolase; Provisional; Region: PRK08186
634457003969	Amidase; Region: Amidase; cl11426
634457003970	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634457003971	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634457003972	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
634457003973	Part of AAA domain; Region: AAA_19; pfam13245
634457003974	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
634457003975	AAA domain; Region: AAA_30; pfam13604
634457003976	AAA domain; Region: AAA_12; pfam13087
634457003977	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
634457003978	putative active site [active]
634457003979	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
634457003980	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
634457003981	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634457003982	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
634457003983	active site
634457003984	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634457003985	ligand-binding site [chemical binding]; other site
634457003986	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457003987	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457003988	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
634457003989	heme ligand [chemical binding]; other site
634457003990	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457003991	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457003992	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
634457003993	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
634457003994	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
634457003995	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
634457003996	active site
634457003997	non-prolyl cis peptide bond; other site
634457003998	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634457003999	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457004000	Flavin Reductases; Region: FlaRed; cl00801
634457004001	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634457004002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457004003	putative substrate translocation pore; other site
634457004004	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
634457004005	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
634457004006	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
634457004007	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
634457004008	active site
634457004009	dimer interface [polypeptide binding]; other site
634457004010	non-prolyl cis peptide bond; other site
634457004011	insertion regions; other site
634457004012	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782
634457004013	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
634457004014	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
634457004015	active site
634457004016	non-prolyl cis peptide bond; other site
634457004017	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
634457004018	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634457004019	active site
634457004020	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
634457004021	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
634457004022	putative FMN binding site [chemical binding]; other site
634457004023	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457004024	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457004025	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457004026	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634457004027	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634457004028	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634457004029	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634457004030	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634457004031	ATP binding site [chemical binding]; other site
634457004032	putative Mg++ binding site [ion binding]; other site
634457004033	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457004034	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
634457004035	Protein of unknown function DUF45; Region: DUF45; pfam01863
634457004036	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634457004037	DNA-binding interface [nucleotide binding]; DNA binding site
634457004038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634457004039	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634457004040	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634457004041	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634457004042	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634457004043	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634457004044	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457004045	HTH-like domain; Region: HTH_21; pfam13276
634457004046	Integrase core domain; Region: rve; pfam00665
634457004047	Integrase core domain; Region: rve_3; pfam13683
634457004048	Transposase; Region: HTH_Tnp_1; pfam01527
634457004049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457004050	Walker A/P-loop; other site
634457004051	ATP binding site [chemical binding]; other site
634457004052	Q-loop/lid; other site
634457004053	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457004054	ABC transporter signature motif; other site
634457004055	Walker B; other site
634457004056	D-loop; other site
634457004057	H-loop/switch region; other site
634457004058	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457004059	AAA domain; Region: AAA_21; pfam13304
634457004060	Walker A/P-loop; other site
634457004061	ATP binding site [chemical binding]; other site
634457004062	Q-loop/lid; other site
634457004063	ABC transporter signature motif; other site
634457004064	Walker B; other site
634457004065	D-loop; other site
634457004066	H-loop/switch region; other site
634457004067	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
634457004068	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
634457004069	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
634457004070	glutaredoxin 2; Provisional; Region: PRK10387
634457004071	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
634457004072	C-terminal domain interface [polypeptide binding]; other site
634457004073	GSH binding site (G-site) [chemical binding]; other site
634457004074	catalytic residues [active]
634457004075	putative dimer interface [polypeptide binding]; other site
634457004076	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
634457004077	N-terminal domain interface [polypeptide binding]; other site
634457004078	polyol permease family; Region: 2A0118; TIGR00897
634457004079	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457004080	putative substrate translocation pore; other site
634457004081	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
634457004082	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
634457004083	active site
634457004084	SAM binding site [chemical binding]; other site
634457004085	homodimer interface [polypeptide binding]; other site
634457004086	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
634457004087	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
634457004088	active site
634457004089	putative homodimer interface [polypeptide binding]; other site
634457004090	SAM binding site [chemical binding]; other site
634457004091	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
634457004092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457004093	S-adenosylmethionine binding site [chemical binding]; other site
634457004094	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
634457004095	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
634457004096	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
634457004097	active site
634457004098	SAM binding site [chemical binding]; other site
634457004099	homodimer interface [polypeptide binding]; other site
634457004100	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
634457004101	active site
634457004102	SAM binding site [chemical binding]; other site
634457004103	homodimer interface [polypeptide binding]; other site
634457004104	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
634457004105	Precorrin-8X methylmutase; Region: CbiC; pfam02570
634457004106	precorrin-3B synthase; Region: CobG; TIGR02435
634457004107	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634457004108	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634457004109	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
634457004110	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
634457004111	fumarate hydratase; Reviewed; Region: fumC; PRK00485
634457004112	Class II fumarases; Region: Fumarase_classII; cd01362
634457004113	active site
634457004114	tetramer interface [polypeptide binding]; other site
634457004115	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
634457004116	GAF domain; Region: GAF; cl17456
634457004117	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
634457004118	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
634457004119	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
634457004120	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
634457004121	Trp docking motif [polypeptide binding]; other site
634457004122	putative active site [active]
634457004123	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634457004124	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
634457004125	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
634457004126	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
634457004127	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
634457004128	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
634457004129	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
634457004130	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634457004131	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
634457004132	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634457004133	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
634457004134	propionate/acetate kinase; Provisional; Region: PRK12379
634457004135	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
634457004136	phosphate acetyltransferase; Provisional; Region: PRK11890
634457004137	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
634457004138	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
634457004139	phosphate binding site [ion binding]; other site
634457004140	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
634457004141	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
634457004142	dimer interface [polypeptide binding]; other site
634457004143	PYR/PP interface [polypeptide binding]; other site
634457004144	TPP binding site [chemical binding]; other site
634457004145	substrate binding site [chemical binding]; other site
634457004146	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
634457004147	Domain of unknown function; Region: EKR; pfam10371
634457004148	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
634457004149	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
634457004150	TPP-binding site [chemical binding]; other site
634457004151	dimer interface [polypeptide binding]; other site
634457004152	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
634457004153	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634457004154	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634457004155	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
634457004156	Ca2+ binding site [ion binding]; other site
634457004157	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634457004158	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634457004159	Predicted membrane protein [Function unknown]; Region: COG1971
634457004160	Domain of unknown function DUF; Region: DUF204; pfam02659
634457004161	Domain of unknown function DUF; Region: DUF204; pfam02659
634457004162	glutathionine S-transferase; Provisional; Region: PRK10542
634457004163	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
634457004164	C-terminal domain interface [polypeptide binding]; other site
634457004165	GSH binding site (G-site) [chemical binding]; other site
634457004166	dimer interface [polypeptide binding]; other site
634457004167	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
634457004168	dimer interface [polypeptide binding]; other site
634457004169	N-terminal domain interface [polypeptide binding]; other site
634457004170	substrate binding pocket (H-site) [chemical binding]; other site
634457004171	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
634457004172	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
634457004173	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
634457004174	GTP binding site; other site
634457004175	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
634457004176	Walker A motif; other site
634457004177	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
634457004178	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
634457004179	dimer interface [polypeptide binding]; other site
634457004180	putative functional site; other site
634457004181	putative MPT binding site; other site
634457004182	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
634457004183	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
634457004184	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
634457004185	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
634457004186	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
634457004187	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
634457004188	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
634457004189	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
634457004190	[4Fe-4S] binding site [ion binding]; other site
634457004191	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
634457004192	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
634457004193	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
634457004194	molybdopterin cofactor binding site; other site
634457004195	exopolyphosphatase; Region: exo_poly_only; TIGR03706
634457004196	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
634457004197	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
634457004198	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457004199	S-adenosylmethionine binding site [chemical binding]; other site
634457004200	fructokinase; Reviewed; Region: PRK09557
634457004201	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
634457004202	nucleotide binding site [chemical binding]; other site
634457004203	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
634457004204	CPxP  motif; other site
634457004205	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
634457004206	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
634457004207	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
634457004208	substrate binding pocket [chemical binding]; other site
634457004209	chain length determination region; other site
634457004210	substrate-Mg2+ binding site; other site
634457004211	catalytic residues [active]
634457004212	aspartate-rich region 1; other site
634457004213	active site lid residues [active]
634457004214	aspartate-rich region 2; other site
634457004215	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
634457004216	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
634457004217	TPP-binding site; other site
634457004218	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634457004219	PYR/PP interface [polypeptide binding]; other site
634457004220	dimer interface [polypeptide binding]; other site
634457004221	TPP binding site [chemical binding]; other site
634457004222	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634457004223	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
634457004224	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634457004225	RNA binding surface [nucleotide binding]; other site
634457004226	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457004227	S-adenosylmethionine binding site [chemical binding]; other site
634457004228	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
634457004229	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457004230	FeS/SAM binding site; other site
634457004231	argininosuccinate synthase; Provisional; Region: PRK13820
634457004232	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
634457004233	ANP binding site [chemical binding]; other site
634457004234	Substrate Binding Site II [chemical binding]; other site
634457004235	Substrate Binding Site I [chemical binding]; other site
634457004236	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
634457004237	Cytochrome c; Region: Cytochrom_C; pfam00034
634457004238	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
634457004239	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
634457004240	active site
634457004241	HIGH motif; other site
634457004242	dimer interface [polypeptide binding]; other site
634457004243	KMSKS motif; other site
634457004244	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634457004245	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634457004246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457004247	active site
634457004248	phosphorylation site [posttranslational modification]
634457004249	intermolecular recognition site; other site
634457004250	dimerization interface [polypeptide binding]; other site
634457004251	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634457004252	DNA binding site [nucleotide binding]
634457004253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
634457004254	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634457004255	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
634457004256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457004257	S-adenosylmethionine binding site [chemical binding]; other site
634457004258	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
634457004259	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
634457004260	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
634457004261	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
634457004262	active site
634457004263	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
634457004264	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
634457004265	peptide binding site [polypeptide binding]; other site
634457004266	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
634457004267	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457004268	dimer interface [polypeptide binding]; other site
634457004269	conserved gate region; other site
634457004270	ABC-ATPase subunit interface; other site
634457004271	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
634457004272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457004273	dimer interface [polypeptide binding]; other site
634457004274	conserved gate region; other site
634457004275	putative PBP binding loops; other site
634457004276	ABC-ATPase subunit interface; other site
634457004277	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
634457004278	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
634457004279	Walker A/P-loop; other site
634457004280	ATP binding site [chemical binding]; other site
634457004281	Q-loop/lid; other site
634457004282	ABC transporter signature motif; other site
634457004283	Walker B; other site
634457004284	D-loop; other site
634457004285	H-loop/switch region; other site
634457004286	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
634457004287	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
634457004288	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
634457004289	Walker A/P-loop; other site
634457004290	ATP binding site [chemical binding]; other site
634457004291	Q-loop/lid; other site
634457004292	ABC transporter signature motif; other site
634457004293	Walker B; other site
634457004294	D-loop; other site
634457004295	H-loop/switch region; other site
634457004296	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
634457004297	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
634457004298	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
634457004299	FMN binding site [chemical binding]; other site
634457004300	substrate binding site [chemical binding]; other site
634457004301	putative catalytic residue [active]
634457004302	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
634457004303	active site
634457004304	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
634457004305	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
634457004306	CAS motifs; other site
634457004307	active site
634457004308	Purine nucleoside permease (NUP); Region: NUP; pfam06516
634457004309	Phosphoesterase family; Region: Phosphoesterase; pfam04185
634457004310	Phosphoesterase family; Region: Phosphoesterase; pfam04185
634457004311	Domain of unknown function (DUF756); Region: DUF756; pfam05506
634457004312	Domain of unknown function (DUF756); Region: DUF756; pfam05506
634457004313	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634457004314	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457004315	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
634457004316	Tannase and feruloyl esterase; Region: Tannase; pfam07519
634457004317	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634457004318	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457004319	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634457004320	putative substrate translocation pore; other site
634457004321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457004322	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
634457004323	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
634457004324	FAD binding pocket [chemical binding]; other site
634457004325	FAD binding motif [chemical binding]; other site
634457004326	phosphate binding motif [ion binding]; other site
634457004327	NAD binding pocket [chemical binding]; other site
634457004328	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
634457004329	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457004330	S-adenosylmethionine binding site [chemical binding]; other site
634457004331	Predicted transcriptional regulators [Transcription]; Region: COG1695
634457004332	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
634457004333	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634457004334	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457004335	multidrug resistance protein MdtN; Provisional; Region: PRK10476
634457004336	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634457004337	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457004338	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634457004339	Outer membrane efflux protein; Region: OEP; pfam02321
634457004340	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
634457004341	B12 binding site [chemical binding]; other site
634457004342	Radical SAM superfamily; Region: Radical_SAM; pfam04055
634457004343	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
634457004344	FeS/SAM binding site; other site
634457004345	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
634457004346	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
634457004347	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634457004348	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634457004349	N-terminal plug; other site
634457004350	ligand-binding site [chemical binding]; other site
634457004351	Conserved TM helix; Region: TM_helix; pfam05552
634457004352	Mechanosensitive ion channel; Region: MS_channel; pfam00924
634457004353	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
634457004354	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
634457004355	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
634457004356	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
634457004357	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
634457004358	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
634457004359	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457004360	Walker A/P-loop; other site
634457004361	ATP binding site [chemical binding]; other site
634457004362	Q-loop/lid; other site
634457004363	ABC transporter signature motif; other site
634457004364	Walker B; other site
634457004365	D-loop; other site
634457004366	H-loop/switch region; other site
634457004367	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
634457004368	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634457004369	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457004370	Walker A/P-loop; other site
634457004371	ATP binding site [chemical binding]; other site
634457004372	Q-loop/lid; other site
634457004373	ABC transporter signature motif; other site
634457004374	Walker B; other site
634457004375	D-loop; other site
634457004376	H-loop/switch region; other site
634457004377	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
634457004378	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
634457004379	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634457004380	N-terminal plug; other site
634457004381	ligand-binding site [chemical binding]; other site
634457004382	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634457004383	Sel1-like repeats; Region: SEL1; smart00671
634457004384	Sel1-like repeats; Region: SEL1; smart00671
634457004385	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457004386	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457004387	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
634457004388	active site
634457004389	homotetramer interface [polypeptide binding]; other site
634457004390	homodimer interface [polypeptide binding]; other site
634457004391	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
634457004392	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634457004393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457004394	homodimer interface [polypeptide binding]; other site
634457004395	catalytic residue [active]
634457004396	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
634457004397	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
634457004398	TrkA-C domain; Region: TrkA_C; pfam02080
634457004399	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
634457004400	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
634457004401	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634457004402	active site
634457004403	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
634457004404	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634457004405	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634457004406	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457004407	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
634457004408	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634457004409	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457004410	Walker A/P-loop; other site
634457004411	ATP binding site [chemical binding]; other site
634457004412	Q-loop/lid; other site
634457004413	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634457004414	ABC transporter signature motif; other site
634457004415	Walker B; other site
634457004416	ABC transporter; Region: ABC_tran_2; pfam12848
634457004417	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634457004418	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457004419	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457004420	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634457004421	dimerization interface [polypeptide binding]; other site
634457004422	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457004423	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
634457004424	Hint domain; Region: Hint_2; pfam13403
634457004425	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634457004426	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634457004427	N-terminal plug; other site
634457004428	ligand-binding site [chemical binding]; other site
634457004429	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
634457004430	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
634457004431	putative NAD(P) binding site [chemical binding]; other site
634457004432	putative substrate binding site [chemical binding]; other site
634457004433	catalytic Zn binding site [ion binding]; other site
634457004434	structural Zn binding site [ion binding]; other site
634457004435	dimer interface [polypeptide binding]; other site
634457004436	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457004437	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
634457004438	SnoaL-like domain; Region: SnoaL_2; pfam12680
634457004439	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
634457004440	dimerization interface [polypeptide binding]; other site
634457004441	metal binding site [ion binding]; metal-binding site
634457004442	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634457004443	catalytic core [active]
634457004444	MgtC family; Region: MgtC; pfam02308
634457004445	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634457004446	putative CoA-transferase; Provisional; Region: PRK11430
634457004447	CoA-transferase family III; Region: CoA_transf_3; pfam02515
634457004448	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
634457004449	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457004450	oxalyl-CoA decarboxylase; Region: oxalate_oxc; TIGR03254
634457004451	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634457004452	PYR/PP interface [polypeptide binding]; other site
634457004453	dimer interface [polypeptide binding]; other site
634457004454	TPP binding site [chemical binding]; other site
634457004455	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634457004456	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
634457004457	TPP-binding site; other site
634457004458	dimer interface [polypeptide binding]; other site
634457004459	formyl-coenzyme A transferase; Provisional; Region: PRK05398
634457004460	CoA-transferase family III; Region: CoA_transf_3; pfam02515
634457004461	oxidoreductase; Provisional; Region: PRK12742
634457004462	classical (c) SDRs; Region: SDR_c; cd05233
634457004463	NAD(P) binding site [chemical binding]; other site
634457004464	active site
634457004465	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634457004466	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634457004467	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
634457004468	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457004469	NAD(P) binding site [chemical binding]; other site
634457004470	active site
634457004471	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
634457004472	putative hydrophobic ligand binding site [chemical binding]; other site
634457004473	protein interface [polypeptide binding]; other site
634457004474	gate; other site
634457004475	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457004476	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634457004477	putative substrate translocation pore; other site
634457004478	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457004479	phosphoglucomutase; Validated; Region: PRK07564
634457004480	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
634457004481	active site
634457004482	substrate binding site [chemical binding]; other site
634457004483	metal binding site [ion binding]; metal-binding site
634457004484	maltose O-acetyltransferase; Provisional; Region: PRK10092
634457004485	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
634457004486	active site
634457004487	substrate binding site [chemical binding]; other site
634457004488	trimer interface [polypeptide binding]; other site
634457004489	CoA binding site [chemical binding]; other site
634457004490	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
634457004491	Hint domain; Region: Hint_2; pfam13403
634457004492	HTH-like domain; Region: HTH_21; pfam13276
634457004493	Integrase core domain; Region: rve; pfam00665
634457004494	Integrase core domain; Region: rve_3; pfam13683
634457004495	Transposase; Region: HTH_Tnp_1; pfam01527
634457004496	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
634457004497	FecR protein; Region: FecR; pfam04773
634457004498	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
634457004499	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634457004500	DNA binding residues [nucleotide binding]
634457004501	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
634457004502	sensor protein QseC; Provisional; Region: PRK10337
634457004503	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634457004504	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634457004505	dimer interface [polypeptide binding]; other site
634457004506	phosphorylation site [posttranslational modification]
634457004507	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634457004508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457004509	active site
634457004510	phosphorylation site [posttranslational modification]
634457004511	intermolecular recognition site; other site
634457004512	dimerization interface [polypeptide binding]; other site
634457004513	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634457004514	DNA binding site [nucleotide binding]
634457004515	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
634457004516	HlyD family secretion protein; Region: HlyD_2; pfam12700
634457004517	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634457004518	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457004519	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634457004520	Outer membrane efflux protein; Region: OEP; pfam02321
634457004521	acyl-CoA synthetase; Validated; Region: PRK09192
634457004522	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
634457004523	acyl-activating enzyme (AAE) consensus motif; other site
634457004524	active site
634457004525	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
634457004526	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
634457004527	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
634457004528	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634457004529	catalytic residue [active]
634457004530	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
634457004531	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
634457004532	active site
634457004533	metal binding site [ion binding]; metal-binding site
634457004534	Predicted permeases [General function prediction only]; Region: COG0795
634457004535	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634457004536	Predicted permeases [General function prediction only]; Region: COG0795
634457004537	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634457004538	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
634457004539	active site
634457004540	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
634457004541	phosphoglycolate phosphatase; Provisional; Region: PRK13222
634457004542	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634457004543	motif II; other site
634457004544	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
634457004545	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
634457004546	Substrate binding site; other site
634457004547	Mg++ binding site; other site
634457004548	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
634457004549	active site
634457004550	substrate binding site [chemical binding]; other site
634457004551	CoA binding site [chemical binding]; other site
634457004552	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
634457004553	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
634457004554	glutaminase active site [active]
634457004555	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
634457004556	dimer interface [polypeptide binding]; other site
634457004557	active site
634457004558	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
634457004559	dimer interface [polypeptide binding]; other site
634457004560	active site
634457004561	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457004562	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457004563	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457004564	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457004565	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457004566	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
634457004567	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
634457004568	Transcriptional regulator [Transcription]; Region: IclR; COG1414
634457004569	Bacterial transcriptional regulator; Region: IclR; pfam01614
634457004570	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
634457004571	catalytic residues [active]
634457004572	dimer interface [polypeptide binding]; other site
634457004573	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
634457004574	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
634457004575	Walker A/P-loop; other site
634457004576	ATP binding site [chemical binding]; other site
634457004577	Q-loop/lid; other site
634457004578	ABC transporter signature motif; other site
634457004579	Walker B; other site
634457004580	D-loop; other site
634457004581	H-loop/switch region; other site
634457004582	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
634457004583	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
634457004584	FtsX-like permease family; Region: FtsX; pfam02687
634457004585	prolyl-tRNA synthetase; Provisional; Region: PRK12325
634457004586	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
634457004587	dimer interface [polypeptide binding]; other site
634457004588	motif 1; other site
634457004589	active site
634457004590	motif 2; other site
634457004591	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
634457004592	active site
634457004593	motif 3; other site
634457004594	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
634457004595	anticodon binding site; other site
634457004596	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
634457004597	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
634457004598	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
634457004599	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
634457004600	nucleotide binding site [chemical binding]; other site
634457004601	Type III pantothenate kinase; Region: Pan_kinase; cl17198
634457004602	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
634457004603	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
634457004604	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
634457004605	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
634457004606	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
634457004607	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
634457004608	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
634457004609	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
634457004610	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
634457004611	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
634457004612	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
634457004613	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
634457004614	4Fe-4S binding domain; Region: Fer4; cl02805
634457004615	4Fe-4S binding domain; Region: Fer4; pfam00037
634457004616	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
634457004617	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
634457004618	NADH dehydrogenase subunit G; Validated; Region: PRK09130
634457004619	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634457004620	catalytic loop [active]
634457004621	iron binding site [ion binding]; other site
634457004622	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
634457004623	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
634457004624	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
634457004625	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
634457004626	SLBB domain; Region: SLBB; pfam10531
634457004627	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
634457004628	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
634457004629	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
634457004630	putative dimer interface [polypeptide binding]; other site
634457004631	[2Fe-2S] cluster binding site [ion binding]; other site
634457004632	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
634457004633	NADH dehydrogenase subunit D; Validated; Region: PRK06075
634457004634	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
634457004635	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
634457004636	NADH dehydrogenase subunit B; Validated; Region: PRK06411
634457004637	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
634457004638	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634457004639	IHF dimer interface [polypeptide binding]; other site
634457004640	IHF - DNA interface [nucleotide binding]; other site
634457004641	Found in ATP-dependent protease La (LON); Region: LON; smart00464
634457004642	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
634457004643	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457004644	Walker A motif; other site
634457004645	ATP binding site [chemical binding]; other site
634457004646	Walker B motif; other site
634457004647	arginine finger; other site
634457004648	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
634457004649	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
634457004650	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
634457004651	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457004652	Walker A motif; other site
634457004653	ATP binding site [chemical binding]; other site
634457004654	Walker B motif; other site
634457004655	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
634457004656	Clp protease; Region: CLP_protease; pfam00574
634457004657	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
634457004658	oligomer interface [polypeptide binding]; other site
634457004659	active site residues [active]
634457004660	trigger factor; Provisional; Region: tig; PRK01490
634457004661	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
634457004662	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
634457004663	Uncharacterized conserved protein [Function unknown]; Region: COG0062
634457004664	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
634457004665	putative substrate binding site [chemical binding]; other site
634457004666	putative ATP binding site [chemical binding]; other site
634457004667	Predicted integral membrane protein [Function unknown]; Region: COG5615
634457004668	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
634457004669	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634457004670	ATP binding site [chemical binding]; other site
634457004671	Mg++ binding site [ion binding]; other site
634457004672	motif III; other site
634457004673	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634457004674	nucleotide binding region [chemical binding]; other site
634457004675	ATP-binding site [chemical binding]; other site
634457004676	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
634457004677	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
634457004678	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
634457004679	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
634457004680	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
634457004681	trimerization site [polypeptide binding]; other site
634457004682	active site
634457004683	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
634457004684	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
634457004685	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634457004686	catalytic residue [active]
634457004687	FeS assembly protein SufD; Region: sufD; TIGR01981
634457004688	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
634457004689	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
634457004690	FeS assembly ATPase SufC; Region: sufC; TIGR01978
634457004691	Walker A/P-loop; other site
634457004692	ATP binding site [chemical binding]; other site
634457004693	Q-loop/lid; other site
634457004694	ABC transporter signature motif; other site
634457004695	Walker B; other site
634457004696	D-loop; other site
634457004697	H-loop/switch region; other site
634457004698	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
634457004699	putative ABC transporter; Region: ycf24; CHL00085
634457004700	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
634457004701	Transcriptional regulator; Region: Rrf2; pfam02082
634457004702	Transcriptional regulator; Region: Rrf2; cl17282
634457004703	Protein of unknown function (DUF445); Region: DUF445; pfam04286
634457004704	Peroxin-3; Region: Peroxin-3; pfam04882
634457004705	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
634457004706	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634457004707	elongation factor G; Reviewed; Region: PRK12739
634457004708	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
634457004709	G1 box; other site
634457004710	putative GEF interaction site [polypeptide binding]; other site
634457004711	GTP/Mg2+ binding site [chemical binding]; other site
634457004712	Switch I region; other site
634457004713	G2 box; other site
634457004714	G3 box; other site
634457004715	Switch II region; other site
634457004716	G4 box; other site
634457004717	G5 box; other site
634457004718	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
634457004719	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
634457004720	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
634457004721	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
634457004722	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634457004723	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
634457004724	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
634457004725	Walker A/P-loop; other site
634457004726	ATP binding site [chemical binding]; other site
634457004727	Q-loop/lid; other site
634457004728	ABC transporter signature motif; other site
634457004729	Walker B; other site
634457004730	D-loop; other site
634457004731	H-loop/switch region; other site
634457004732	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
634457004733	nudix motif; other site
634457004734	PII uridylyl-transferase; Provisional; Region: PRK05092
634457004735	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
634457004736	metal binding triad; other site
634457004737	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
634457004738	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
634457004739	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
634457004740	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
634457004741	MutS domain I; Region: MutS_I; pfam01624
634457004742	MutS domain II; Region: MutS_II; pfam05188
634457004743	MutS domain III; Region: MutS_III; pfam05192
634457004744	MutS domain V; Region: MutS_V; pfam00488
634457004745	Walker A/P-loop; other site
634457004746	ATP binding site [chemical binding]; other site
634457004747	Q-loop/lid; other site
634457004748	ABC transporter signature motif; other site
634457004749	Walker B; other site
634457004750	D-loop; other site
634457004751	H-loop/switch region; other site
634457004752	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
634457004753	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634457004754	binding surface
634457004755	TPR motif; other site
634457004756	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634457004757	binding surface
634457004758	TPR motif; other site
634457004759	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
634457004760	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
634457004761	active site
634457004762	Zn binding site [ion binding]; other site
634457004763	Major royal jelly protein; Region: MRJP; pfam03022
634457004764	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
634457004765	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
634457004766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457004767	catalytic residue [active]
634457004768	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
634457004769	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
634457004770	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
634457004771	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
634457004772	Tim44-like domain; Region: Tim44; pfam04280
634457004773	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
634457004774	UbiA prenyltransferase family; Region: UbiA; pfam01040
634457004775	cytochrome c oxidase subunit I; Provisional; Region: COX1; MTH00182
634457004776	cytochrome c oxidase subunit I; Provisional; Region: COX1; MTH00182
634457004777	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457004778	S-adenosylmethionine binding site [chemical binding]; other site
634457004779	glutathione synthetase; Provisional; Region: PRK05246
634457004780	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
634457004781	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
634457004782	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
634457004783	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
634457004784	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
634457004785	Ligand binding site; other site
634457004786	Putative Catalytic site; other site
634457004787	DXD motif; other site
634457004788	Predicted membrane protein [Function unknown]; Region: COG2246
634457004789	GtrA-like protein; Region: GtrA; pfam04138
634457004790	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
634457004791	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
634457004792	putative Zn2+ binding site [ion binding]; other site
634457004793	AsnC family; Region: AsnC_trans_reg; pfam01037
634457004794	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
634457004795	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634457004796	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634457004797	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457004798	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457004799	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634457004800	putative effector binding pocket; other site
634457004801	dimerization interface [polypeptide binding]; other site
634457004802	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
634457004803	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634457004804	IHF - DNA interface [nucleotide binding]; other site
634457004805	IHF dimer interface [polypeptide binding]; other site
634457004806	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
634457004807	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
634457004808	Fe-S cluster binding site [ion binding]; other site
634457004809	active site
634457004810	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
634457004811	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
634457004812	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634457004813	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634457004814	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
634457004815	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
634457004816	DNA binding residues [nucleotide binding]
634457004817	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634457004818	IHF - DNA interface [nucleotide binding]; other site
634457004819	IHF dimer interface [polypeptide binding]; other site
634457004820	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
634457004821	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
634457004822	dimer interface [polypeptide binding]; other site
634457004823	active site
634457004824	CoA binding pocket [chemical binding]; other site
634457004825	putative phosphate acyltransferase; Provisional; Region: PRK05331
634457004826	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
634457004827	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
634457004828	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
634457004829	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
634457004830	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
634457004831	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634457004832	dimerization interface [polypeptide binding]; other site
634457004833	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457004834	ATP binding site [chemical binding]; other site
634457004835	Mg2+ binding site [ion binding]; other site
634457004836	G-X-G motif; other site
634457004837	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634457004838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457004839	active site
634457004840	phosphorylation site [posttranslational modification]
634457004841	intermolecular recognition site; other site
634457004842	dimerization interface [polypeptide binding]; other site
634457004843	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634457004844	DNA binding site [nucleotide binding]
634457004845	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
634457004846	MarR family; Region: MarR_2; pfam12802
634457004847	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
634457004848	COQ9; Region: COQ9; pfam08511
634457004849	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
634457004850	active site
634457004851	catalytic residues [active]
634457004852	metal binding site [ion binding]; metal-binding site
634457004853	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
634457004854	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
634457004855	tartrate dehydrogenase; Region: TTC; TIGR02089
634457004856	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
634457004857	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
634457004858	substrate binding site [chemical binding]; other site
634457004859	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
634457004860	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
634457004861	substrate binding site [chemical binding]; other site
634457004862	ligand binding site [chemical binding]; other site
634457004863	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
634457004864	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
634457004865	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
634457004866	RimM N-terminal domain; Region: RimM; pfam01782
634457004867	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
634457004868	signal recognition particle protein; Provisional; Region: PRK10867
634457004869	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
634457004870	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
634457004871	P loop; other site
634457004872	GTP binding site [chemical binding]; other site
634457004873	Signal peptide binding domain; Region: SRP_SPB; pfam02978
634457004874	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
634457004875	dimer interface [polypeptide binding]; other site
634457004876	ATP12 chaperone protein; Region: ATP12; pfam07542
634457004877	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634457004878	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
634457004879	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634457004880	RNA binding surface [nucleotide binding]; other site
634457004881	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
634457004882	active site
634457004883	recombination factor protein RarA; Reviewed; Region: PRK13342
634457004884	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457004885	Walker A motif; other site
634457004886	ATP binding site [chemical binding]; other site
634457004887	Walker B motif; other site
634457004888	arginine finger; other site
634457004889	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
634457004890	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
634457004891	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
634457004892	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
634457004893	UbiA prenyltransferase family; Region: UbiA; pfam01040
634457004894	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
634457004895	RNA methyltransferase, RsmE family; Region: TIGR00046
634457004896	glutamate--cysteine ligase; Region: PLN02611
634457004897	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457004898	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634457004899	putative substrate translocation pore; other site
634457004900	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457004901	GTP-binding protein Der; Reviewed; Region: PRK00093
634457004902	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
634457004903	G1 box; other site
634457004904	GTP/Mg2+ binding site [chemical binding]; other site
634457004905	Switch I region; other site
634457004906	G2 box; other site
634457004907	Switch II region; other site
634457004908	G3 box; other site
634457004909	G4 box; other site
634457004910	G5 box; other site
634457004911	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
634457004912	G1 box; other site
634457004913	GTP/Mg2+ binding site [chemical binding]; other site
634457004914	Switch I region; other site
634457004915	G2 box; other site
634457004916	G3 box; other site
634457004917	Switch II region; other site
634457004918	G4 box; other site
634457004919	G5 box; other site
634457004920	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
634457004921	Trp docking motif [polypeptide binding]; other site
634457004922	active site
634457004923	PQQ-like domain; Region: PQQ_2; pfam13360
634457004924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
634457004925	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
634457004926	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
634457004927	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
634457004928	putative active site [active]
634457004929	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
634457004930	putative ADP-binding pocket [chemical binding]; other site
634457004931	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457004932	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
634457004933	active site
634457004934	dimer interface [polypeptide binding]; other site
634457004935	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
634457004936	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
634457004937	Ligand Binding Site [chemical binding]; other site
634457004938	Molecular Tunnel; other site
634457004939	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
634457004940	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
634457004941	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
634457004942	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
634457004943	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
634457004944	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
634457004945	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
634457004946	Sulfate transporter family; Region: Sulfate_transp; pfam00916
634457004947	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
634457004948	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
634457004949	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
634457004950	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
634457004951	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
634457004952	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
634457004953	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
634457004954	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
634457004955	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
634457004956	Clp amino terminal domain; Region: Clp_N; pfam02861
634457004957	Clp amino terminal domain; Region: Clp_N; pfam02861
634457004958	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457004959	Walker A motif; other site
634457004960	ATP binding site [chemical binding]; other site
634457004961	Walker B motif; other site
634457004962	arginine finger; other site
634457004963	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457004964	Walker A motif; other site
634457004965	ATP binding site [chemical binding]; other site
634457004966	Walker B motif; other site
634457004967	arginine finger; other site
634457004968	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
634457004969	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
634457004970	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
634457004971	nudix motif; other site
634457004972	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
634457004973	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
634457004974	HflX GTPase family; Region: HflX; cd01878
634457004975	G1 box; other site
634457004976	GTP/Mg2+ binding site [chemical binding]; other site
634457004977	Switch I region; other site
634457004978	G2 box; other site
634457004979	G3 box; other site
634457004980	Switch II region; other site
634457004981	G4 box; other site
634457004982	G5 box; other site
634457004983	bacterial Hfq-like; Region: Hfq; cd01716
634457004984	hexamer interface [polypeptide binding]; other site
634457004985	Sm1 motif; other site
634457004986	RNA binding site [nucleotide binding]; other site
634457004987	Sm2 motif; other site
634457004988	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
634457004989	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457004990	active site
634457004991	phosphorylation site [posttranslational modification]
634457004992	intermolecular recognition site; other site
634457004993	dimerization interface [polypeptide binding]; other site
634457004994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457004995	Walker A motif; other site
634457004996	ATP binding site [chemical binding]; other site
634457004997	Walker B motif; other site
634457004998	arginine finger; other site
634457004999	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
634457005000	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
634457005001	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634457005002	dimerization interface [polypeptide binding]; other site
634457005003	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634457005004	dimer interface [polypeptide binding]; other site
634457005005	phosphorylation site [posttranslational modification]
634457005006	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457005007	ATP binding site [chemical binding]; other site
634457005008	Mg2+ binding site [ion binding]; other site
634457005009	G-X-G motif; other site
634457005010	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
634457005011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457005012	active site
634457005013	phosphorylation site [posttranslational modification]
634457005014	intermolecular recognition site; other site
634457005015	dimerization interface [polypeptide binding]; other site
634457005016	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457005017	Walker A motif; other site
634457005018	ATP binding site [chemical binding]; other site
634457005019	Walker B motif; other site
634457005020	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
634457005021	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
634457005022	PAS domain; Region: PAS; smart00091
634457005023	putative active site [active]
634457005024	heme pocket [chemical binding]; other site
634457005025	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634457005026	dimer interface [polypeptide binding]; other site
634457005027	phosphorylation site [posttranslational modification]
634457005028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457005029	ATP binding site [chemical binding]; other site
634457005030	Mg2+ binding site [ion binding]; other site
634457005031	G-X-G motif; other site
634457005032	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
634457005033	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
634457005034	FMN binding site [chemical binding]; other site
634457005035	active site
634457005036	catalytic residues [active]
634457005037	substrate binding site [chemical binding]; other site
634457005038	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
634457005039	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
634457005040	substrate binding site; other site
634457005041	dimer interface; other site
634457005042	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
634457005043	homotrimer interaction site [polypeptide binding]; other site
634457005044	zinc binding site [ion binding]; other site
634457005045	CDP-binding sites; other site
634457005046	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
634457005047	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
634457005048	Ligand binding site; other site
634457005049	Putative Catalytic site; other site
634457005050	DXD motif; other site
634457005051	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634457005052	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634457005053	active site
634457005054	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
634457005055	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634457005056	UDP-galactopyranose mutase; Region: GLF; pfam03275
634457005057	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
634457005058	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634457005059	active site
634457005060	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
634457005061	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634457005062	active site
634457005063	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457005064	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
634457005065	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634457005066	active site
634457005067	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
634457005068	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
634457005069	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
634457005070	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
634457005071	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
634457005072	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
634457005073	Probable transposase; Region: OrfB_IS605; pfam01385
634457005074	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
634457005075	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
634457005076	Nitrogen regulatory protein P-II; Region: P-II; smart00938
634457005077	serine acetyltransferase; Provisional; Region: cysE; PRK11132
634457005078	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
634457005079	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
634457005080	trimer interface [polypeptide binding]; other site
634457005081	active site
634457005082	substrate binding site [chemical binding]; other site
634457005083	CoA binding site [chemical binding]; other site
634457005084	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
634457005085	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
634457005086	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
634457005087	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
634457005088	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
634457005089	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
634457005090	DDE superfamily endonuclease; Region: DDE_5; cl17874
634457005091	elongation factor P; Validated; Region: PRK00529
634457005092	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
634457005093	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
634457005094	RNA binding site [nucleotide binding]; other site
634457005095	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
634457005096	RNA binding site [nucleotide binding]; other site
634457005097	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634457005098	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
634457005099	active site
634457005100	dimerization interface [polypeptide binding]; other site
634457005101	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634457005102	ATP binding site [chemical binding]; other site
634457005103	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
634457005104	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
634457005105	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634457005106	DNA-binding site [nucleotide binding]; DNA binding site
634457005107	RNA-binding motif; other site
634457005108	Dienelactone hydrolase family; Region: DLH; pfam01738
634457005109	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
634457005110	oligomerisation interface [polypeptide binding]; other site
634457005111	mobile loop; other site
634457005112	roof hairpin; other site
634457005113	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
634457005114	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
634457005115	ring oligomerisation interface [polypeptide binding]; other site
634457005116	ATP/Mg binding site [chemical binding]; other site
634457005117	stacking interactions; other site
634457005118	hinge regions; other site
634457005119	FkbH-like domain; Region: FkbH; TIGR01686
634457005120	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634457005121	active site
634457005122	motif I; other site
634457005123	motif II; other site
634457005124	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634457005125	Transposase; Region: HTH_Tnp_1; pfam01527
634457005126	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634457005127	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634457005128	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634457005129	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634457005130	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634457005131	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634457005132	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634457005133	Transposase domain (DUF772); Region: DUF772; pfam05598
634457005134	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457005135	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634457005136	HTH-like domain; Region: HTH_21; pfam13276
634457005137	Integrase core domain; Region: rve; pfam00665
634457005138	Integrase core domain; Region: rve_3; pfam13683
634457005139	Transposase; Region: HTH_Tnp_1; pfam01527
634457005140	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457005141	Transposase domain (DUF772); Region: DUF772; pfam05598
634457005142	GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183
634457005143	Ligand binding site; other site
634457005144	Phosphotransferase enzyme family; Region: APH; pfam01636
634457005145	capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689
634457005146	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457005147	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457005148	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634457005149	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457005150	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
634457005151	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457005152	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
634457005153	GDP-Fucose binding site [chemical binding]; other site
634457005154	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
634457005155	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
634457005156	substrate binding site; other site
634457005157	tetramer interface; other site
634457005158	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
634457005159	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
634457005160	NAD binding site [chemical binding]; other site
634457005161	substrate binding site [chemical binding]; other site
634457005162	homodimer interface [polypeptide binding]; other site
634457005163	active site
634457005164	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457005165	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634457005166	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457005167	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457005168	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457005169	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457005170	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457005171	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457005172	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457005173	Transposase domain (DUF772); Region: DUF772; pfam05598
634457005174	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457005175	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634457005176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634457005177	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634457005178	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634457005179	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634457005180	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634457005181	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634457005182	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634457005183	Transposase; Region: HTH_Tnp_1; pfam01527
634457005184	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634457005185	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
634457005186	active site
634457005187	catalytic triad [active]
634457005188	oxyanion hole [active]
634457005189	Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724
634457005190	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
634457005191	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
634457005192	Aspartyl protease; Region: Asp_protease_2; pfam13650
634457005193	inhibitor binding site; inhibition site
634457005194	catalytic motif [active]
634457005195	Catalytic residue [active]
634457005196	Active site flap [active]
634457005197	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
634457005198	inhibitor binding site; inhibition site
634457005199	catalytic motif [active]
634457005200	Catalytic residue [active]
634457005201	Active site flap [active]
634457005202	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
634457005203	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
634457005204	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457005205	active site
634457005206	DNA binding site [nucleotide binding]
634457005207	Int/Topo IB signature motif; other site
634457005208	primosome assembly protein PriA; Validated; Region: PRK05580
634457005209	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634457005210	ATP binding site [chemical binding]; other site
634457005211	putative Mg++ binding site [ion binding]; other site
634457005212	Preprotein translocase subunit; Region: YajC; pfam02699
634457005213	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
634457005214	Protein of unknown function (DUF815); Region: DUF815; pfam05673
634457005215	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634457005216	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634457005217	[2Fe-2S] cluster binding site [ion binding]; other site
634457005218	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
634457005219	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634457005220	Coenzyme A binding pocket [chemical binding]; other site
634457005221	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
634457005222	active site
634457005223	8-oxo-dGMP binding site [chemical binding]; other site
634457005224	nudix motif; other site
634457005225	metal binding site [ion binding]; metal-binding site
634457005226	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
634457005227	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
634457005228	Substrate binding site; other site
634457005229	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
634457005230	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
634457005231	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
634457005232	homodimer interface [polypeptide binding]; other site
634457005233	substrate-cofactor binding pocket; other site
634457005234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457005235	catalytic residue [active]
634457005236	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
634457005237	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
634457005238	GTP cyclohydrolase I; Provisional; Region: PLN03044
634457005239	active site
634457005240	intracellular protease, PfpI family; Region: PfpI; TIGR01382
634457005241	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
634457005242	conserved cys residue [active]
634457005243	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
634457005244	MPT binding site; other site
634457005245	trimer interface [polypeptide binding]; other site
634457005246	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634457005247	Uncharacterized conserved protein [Function unknown]; Region: COG4717
634457005248	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
634457005249	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
634457005250	active site
634457005251	metal binding site [ion binding]; metal-binding site
634457005252	DNA binding site [nucleotide binding]
634457005253	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634457005254	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
634457005255	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
634457005256	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
634457005257	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634457005258	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457005259	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
634457005260	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
634457005261	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
634457005262	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
634457005263	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
634457005264	homopentamer interface [polypeptide binding]; other site
634457005265	active site
634457005266	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
634457005267	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
634457005268	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
634457005269	dimerization interface [polypeptide binding]; other site
634457005270	active site
634457005271	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
634457005272	Lumazine binding domain; Region: Lum_binding; pfam00677
634457005273	Lumazine binding domain; Region: Lum_binding; pfam00677
634457005274	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
634457005275	catalytic motif [active]
634457005276	Zn binding site [ion binding]; other site
634457005277	RibD C-terminal domain; Region: RibD_C; cl17279
634457005278	cytochrome b; Provisional; Region: CYTB; MTH00145
634457005279	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
634457005280	Qi binding site; other site
634457005281	intrachain domain interface; other site
634457005282	interchain domain interface [polypeptide binding]; other site
634457005283	heme bH binding site [chemical binding]; other site
634457005284	heme bL binding site [chemical binding]; other site
634457005285	Qo binding site; other site
634457005286	interchain domain interface [polypeptide binding]; other site
634457005287	intrachain domain interface; other site
634457005288	Qi binding site; other site
634457005289	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
634457005290	Qo binding site; other site
634457005291	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
634457005292	Cytochrome c; Region: Cytochrom_C; cl11414
634457005293	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
634457005294	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
634457005295	[2Fe-2S] cluster binding site [ion binding]; other site
634457005296	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
634457005297	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
634457005298	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634457005299	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
634457005300	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634457005301	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634457005302	Hint domain; Region: Hint_2; pfam13403
634457005303	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457005304	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
634457005305	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457005306	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
634457005307	Predicted helicase [General function prediction only]; Region: COG4889
634457005308	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634457005309	ATP binding site [chemical binding]; other site
634457005310	putative Mg++ binding site [ion binding]; other site
634457005311	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
634457005312	ATP-binding site [chemical binding]; other site
634457005313	Predicted helicase [General function prediction only]; Region: COG4889
634457005314	Protein of unknown function DUF262; Region: DUF262; pfam03235
634457005315	Uncharacterized conserved protein [Function unknown]; Region: COG1479
634457005316	Protein of unknown function DUF262; Region: DUF262; pfam03235
634457005317	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
634457005318	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
634457005319	HTH-like domain; Region: HTH_21; pfam13276
634457005320	Integrase core domain; Region: rve; pfam00665
634457005321	Integrase core domain; Region: rve_3; pfam13683
634457005322	Transposase; Region: HTH_Tnp_1; pfam01527
634457005323	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
634457005324	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
634457005325	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
634457005326	GTPase CgtA; Reviewed; Region: obgE; PRK12299
634457005327	GTP1/OBG; Region: GTP1_OBG; pfam01018
634457005328	Obg GTPase; Region: Obg; cd01898
634457005329	G1 box; other site
634457005330	GTP/Mg2+ binding site [chemical binding]; other site
634457005331	Switch I region; other site
634457005332	G2 box; other site
634457005333	G3 box; other site
634457005334	Switch II region; other site
634457005335	G4 box; other site
634457005336	G5 box; other site
634457005337	gamma-glutamyl kinase; Provisional; Region: PRK05429
634457005338	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
634457005339	nucleotide binding site [chemical binding]; other site
634457005340	homotetrameric interface [polypeptide binding]; other site
634457005341	putative phosphate binding site [ion binding]; other site
634457005342	putative allosteric binding site; other site
634457005343	PUA domain; Region: PUA; pfam01472
634457005344	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
634457005345	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
634457005346	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
634457005347	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
634457005348	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634457005349	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634457005350	substrate binding pocket [chemical binding]; other site
634457005351	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
634457005352	cell division protein MraZ; Reviewed; Region: PRK00326
634457005353	MraZ protein; Region: MraZ; pfam02381
634457005354	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
634457005355	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457005356	S-adenosylmethionine binding site [chemical binding]; other site
634457005357	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
634457005358	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
634457005359	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
634457005360	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
634457005361	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
634457005362	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
634457005363	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634457005364	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
634457005365	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
634457005366	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
634457005367	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634457005368	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
634457005369	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
634457005370	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
634457005371	Mg++ binding site [ion binding]; other site
634457005372	putative catalytic motif [active]
634457005373	putative substrate binding site [chemical binding]; other site
634457005374	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
634457005375	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634457005376	cell division protein FtsW; Region: ftsW; TIGR02614
634457005377	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
634457005378	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
634457005379	active site
634457005380	homodimer interface [polypeptide binding]; other site
634457005381	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
634457005382	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
634457005383	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634457005384	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
634457005385	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
634457005386	FAD binding domain; Region: FAD_binding_4; pfam01565
634457005387	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
634457005388	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
634457005389	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
634457005390	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634457005391	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
634457005392	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
634457005393	Cell division protein FtsQ; Region: FtsQ; pfam03799
634457005394	Cell division protein FtsA; Region: FtsA; smart00842
634457005395	cell division protein FtsA; Region: ftsA; TIGR01174
634457005396	Cell division protein FtsA; Region: FtsA; pfam14450
634457005397	cell division protein FtsZ; Validated; Region: PRK09330
634457005398	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
634457005399	nucleotide binding site [chemical binding]; other site
634457005400	SulA interaction site; other site
634457005401	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
634457005402	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
634457005403	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
634457005404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
634457005405	binding surface
634457005406	TPR motif; other site
634457005407	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
634457005408	Walker A/P-loop; other site
634457005409	ATP binding site [chemical binding]; other site
634457005410	Q-loop/lid; other site
634457005411	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
634457005412	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
634457005413	ABC transporter signature motif; other site
634457005414	Walker B; other site
634457005415	D-loop; other site
634457005416	H-loop/switch region; other site
634457005417	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
634457005418	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
634457005419	nucleotide binding pocket [chemical binding]; other site
634457005420	K-X-D-G motif; other site
634457005421	catalytic site [active]
634457005422	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
634457005423	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
634457005424	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
634457005425	Dimer interface [polypeptide binding]; other site
634457005426	BRCT sequence motif; other site
634457005427	pyruvate phosphate dikinase; Provisional; Region: PRK09279
634457005428	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
634457005429	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
634457005430	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
634457005431	PEP synthetase regulatory protein; Provisional; Region: PRK05339
634457005432	Uncharacterized conserved protein [Function unknown]; Region: COG1739
634457005433	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
634457005434	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
634457005435	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
634457005436	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
634457005437	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
634457005438	active site
634457005439	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
634457005440	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634457005441	active site
634457005442	HIGH motif; other site
634457005443	nucleotide binding site [chemical binding]; other site
634457005444	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
634457005445	active site
634457005446	KMSKS motif; other site
634457005447	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
634457005448	Isochorismatase family; Region: Isochorismatase; pfam00857
634457005449	catalytic triad [active]
634457005450	metal binding site [ion binding]; metal-binding site
634457005451	conserved cis-peptide bond; other site
634457005452	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
634457005453	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634457005454	metal-binding site [ion binding]
634457005455	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
634457005456	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634457005457	metal-binding site [ion binding]
634457005458	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
634457005459	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634457005460	motif II; other site
634457005461	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
634457005462	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
634457005463	Multicopper oxidase; Region: Cu-oxidase; pfam00394
634457005464	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
634457005465	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
634457005466	ketol-acid reductoisomerase; Provisional; Region: PRK05479
634457005467	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
634457005468	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
634457005469	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
634457005470	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
634457005471	putative valine binding site [chemical binding]; other site
634457005472	dimer interface [polypeptide binding]; other site
634457005473	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
634457005474	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
634457005475	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634457005476	PYR/PP interface [polypeptide binding]; other site
634457005477	dimer interface [polypeptide binding]; other site
634457005478	TPP binding site [chemical binding]; other site
634457005479	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634457005480	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
634457005481	TPP-binding site [chemical binding]; other site
634457005482	dimer interface [polypeptide binding]; other site
634457005483	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
634457005484	tRNA dimethylallyltransferase; Region: miaA; TIGR00174
634457005485	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
634457005486	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634457005487	motif II; other site
634457005488	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
634457005489	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
634457005490	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634457005491	ATP binding site [chemical binding]; other site
634457005492	putative Mg++ binding site [ion binding]; other site
634457005493	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634457005494	nucleotide binding region [chemical binding]; other site
634457005495	ATP-binding site [chemical binding]; other site
634457005496	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457005497	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634457005498	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457005499	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634457005500	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
634457005501	active site
634457005502	Zn binding site [ion binding]; other site
634457005503	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
634457005504	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
634457005505	dimer interface [polypeptide binding]; other site
634457005506	active site
634457005507	glycine-pyridoxal phosphate binding site [chemical binding]; other site
634457005508	folate binding site [chemical binding]; other site
634457005509	amino acid transporter; Region: 2A0306; TIGR00909
634457005510	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
634457005511	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
634457005512	dimer interface [polypeptide binding]; other site
634457005513	allosteric magnesium binding site [ion binding]; other site
634457005514	active site
634457005515	aspartate-rich active site metal binding site; other site
634457005516	Schiff base residues; other site
634457005517	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
634457005518	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
634457005519	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
634457005520	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
634457005521	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
634457005522	CAP-like domain; other site
634457005523	active site
634457005524	primary dimer interface [polypeptide binding]; other site
634457005525	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
634457005526	Recombination protein O N terminal; Region: RecO_N; pfam11967
634457005527	Recombination protein O C terminal; Region: RecO_C; pfam02565
634457005528	elongation factor Ts; Provisional; Region: tsf; PRK09377
634457005529	UBA/TS-N domain; Region: UBA; pfam00627
634457005530	Elongation factor TS; Region: EF_TS; pfam00889
634457005531	Elongation factor TS; Region: EF_TS; pfam00889
634457005532	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
634457005533	rRNA interaction site [nucleotide binding]; other site
634457005534	S8 interaction site; other site
634457005535	putative laminin-1 binding site; other site
634457005536	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634457005537	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634457005538	[2Fe-2S] cluster binding site [ion binding]; other site
634457005539	Selenoprotein P, N terminal region; Region: SelP_N; pfam04592
634457005540	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
634457005541	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
634457005542	homodimer interface [polypeptide binding]; other site
634457005543	substrate-cofactor binding pocket; other site
634457005544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457005545	catalytic residue [active]
634457005546	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
634457005547	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
634457005548	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
634457005549	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
634457005550	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
634457005551	putative active site [active]
634457005552	putative PHP Thumb interface [polypeptide binding]; other site
634457005553	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
634457005554	generic binding surface II; other site
634457005555	generic binding surface I; other site
634457005556	Pantoate-beta-alanine ligase; Region: PanC; cd00560
634457005557	pantoate--beta-alanine ligase; Region: panC; TIGR00018
634457005558	active site
634457005559	ATP-binding site [chemical binding]; other site
634457005560	pantoate-binding site; other site
634457005561	HXXH motif; other site
634457005562	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
634457005563	homotrimer interaction site [polypeptide binding]; other site
634457005564	putative active site [active]
634457005565	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
634457005566	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
634457005567	aspartate aminotransferase; Provisional; Region: PRK05764
634457005568	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634457005569	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457005570	homodimer interface [polypeptide binding]; other site
634457005571	catalytic residue [active]
634457005572	aspartate aminotransferase; Provisional; Region: PRK05764
634457005573	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634457005574	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457005575	homodimer interface [polypeptide binding]; other site
634457005576	catalytic residue [active]
634457005577	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
634457005578	active site
634457005579	HIGH motif; other site
634457005580	nucleotide binding site [chemical binding]; other site
634457005581	active site
634457005582	KMSKS motif; other site
634457005583	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
634457005584	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
634457005585	active site
634457005586	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634457005587	metal-binding site [ion binding]
634457005588	hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367
634457005589	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
634457005590	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457005591	FeS/SAM binding site; other site
634457005592	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
634457005593	active site
634457005594	multimer interface [polypeptide binding]; other site
634457005595	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
634457005596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457005597	Walker A/P-loop; other site
634457005598	ATP binding site [chemical binding]; other site
634457005599	Q-loop/lid; other site
634457005600	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634457005601	ABC transporter; Region: ABC_tran_2; pfam12848
634457005602	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634457005603	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634457005604	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634457005605	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634457005606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457005607	active site
634457005608	phosphorylation site [posttranslational modification]
634457005609	intermolecular recognition site; other site
634457005610	dimerization interface [polypeptide binding]; other site
634457005611	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634457005612	DNA binding site [nucleotide binding]
634457005613	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634457005614	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
634457005615	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
634457005616	dimer interface [polypeptide binding]; other site
634457005617	phosphorylation site [posttranslational modification]
634457005618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457005619	ATP binding site [chemical binding]; other site
634457005620	Mg2+ binding site [ion binding]; other site
634457005621	G-X-G motif; other site
634457005622	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
634457005623	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
634457005624	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
634457005625	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
634457005626	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
634457005627	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
634457005628	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
634457005629	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
634457005630	active site
634457005631	dimer interface [polypeptide binding]; other site
634457005632	motif 1; other site
634457005633	motif 2; other site
634457005634	motif 3; other site
634457005635	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
634457005636	anticodon binding site; other site
634457005637	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
634457005638	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
634457005639	putative active site [active]
634457005640	TPR repeat; Region: TPR_11; pfam13414
634457005641	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634457005642	binding surface
634457005643	TPR motif; other site
634457005644	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457005645	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
634457005646	putative ADP-binding pocket [chemical binding]; other site
634457005647	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
634457005648	ATP-NAD kinase; Region: NAD_kinase; pfam01513
634457005649	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
634457005650	RNA/DNA hybrid binding site [nucleotide binding]; other site
634457005651	active site
634457005652	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
634457005653	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
634457005654	putative active site [active]
634457005655	putative substrate binding site [chemical binding]; other site
634457005656	ATP binding site [chemical binding]; other site
634457005657	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
634457005658	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
634457005659	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
634457005660	ABC1 family; Region: ABC1; cl17513
634457005661	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
634457005662	active site
634457005663	substrate binding site [chemical binding]; other site
634457005664	ATP binding site [chemical binding]; other site
634457005665	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
634457005666	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
634457005667	active site
634457005668	Zn binding site [ion binding]; other site
634457005669	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
634457005670	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
634457005671	active site
634457005672	dimer interface [polypeptide binding]; other site
634457005673	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
634457005674	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
634457005675	active site
634457005676	FMN binding site [chemical binding]; other site
634457005677	substrate binding site [chemical binding]; other site
634457005678	3Fe-4S cluster binding site [ion binding]; other site
634457005679	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
634457005680	domain interface; other site
634457005681	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
634457005682	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634457005683	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634457005684	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
634457005685	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
634457005686	putative NAD(P) binding site [chemical binding]; other site
634457005687	active site
634457005688	EamA-like transporter family; Region: EamA; pfam00892
634457005689	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634457005690	EamA-like transporter family; Region: EamA; pfam00892
634457005691	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
634457005692	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
634457005693	active site
634457005694	metal binding site [ion binding]; metal-binding site
634457005695	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
634457005696	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
634457005697	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
634457005698	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
634457005699	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
634457005700	histidinol dehydrogenase; Region: hisD; TIGR00069
634457005701	NAD binding site [chemical binding]; other site
634457005702	dimerization interface [polypeptide binding]; other site
634457005703	product binding site; other site
634457005704	substrate binding site [chemical binding]; other site
634457005705	zinc binding site [ion binding]; other site
634457005706	catalytic residues [active]
634457005707	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
634457005708	rRNA binding site [nucleotide binding]; other site
634457005709	predicted 30S ribosome binding site; other site
634457005710	Maf-like protein; Region: Maf; pfam02545
634457005711	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
634457005712	active site
634457005713	dimer interface [polypeptide binding]; other site
634457005714	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
634457005715	RNA binding site [nucleotide binding]; other site
634457005716	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
634457005717	Domain of unknown function (DUF329); Region: DUF329; pfam03884
634457005718	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
634457005719	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
634457005720	catalytic residue [active]
634457005721	protease 2; Provisional; Region: PRK10115
634457005722	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
634457005723	Phage capsid family; Region: Phage_capsid; pfam05065
634457005724	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
634457005725	Phage-related protein [Function unknown]; Region: COG4695
634457005726	Phage portal protein; Region: Phage_portal; pfam04860
634457005727	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
634457005728	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
634457005729	active site
634457005730	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
634457005731	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
634457005732	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457005733	active site
634457005734	DNA binding site [nucleotide binding]
634457005735	Int/Topo IB signature motif; other site
634457005736	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
634457005737	Prophage antirepressor [Transcription]; Region: COG3617
634457005738	BRO family, N-terminal domain; Region: Bro-N; smart01040
634457005739	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
634457005740	Predicted transcriptional regulator [Transcription]; Region: COG2932
634457005741	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634457005742	Catalytic site [active]
634457005743	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
634457005744	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
634457005745	active site
634457005746	catalytic site [active]
634457005747	substrate binding site [chemical binding]; other site
634457005748	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634457005749	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634457005750	non-specific DNA binding site [nucleotide binding]; other site
634457005751	salt bridge; other site
634457005752	sequence-specific DNA binding site [nucleotide binding]; other site
634457005753	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634457005754	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457005755	active site
634457005756	DNA binding site [nucleotide binding]
634457005757	Int/Topo IB signature motif; other site
634457005758	Cytochrome c; Region: Cytochrom_C; pfam00034
634457005759	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
634457005760	homotetramer interface [polypeptide binding]; other site
634457005761	short chain dehydrogenase; Validated; Region: PRK07069
634457005762	NAD binding site [chemical binding]; other site
634457005763	homodimer interface [polypeptide binding]; other site
634457005764	active site
634457005765	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
634457005766	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634457005767	NAD binding site [chemical binding]; other site
634457005768	catalytic residues [active]
634457005769	D-lactate dehydrogenase; Provisional; Region: PRK11183
634457005770	FAD binding domain; Region: FAD_binding_4; pfam01565
634457005771	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
634457005772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
634457005773	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
634457005774	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
634457005775	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
634457005776	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
634457005777	Uncharacterized conserved protein [Function unknown]; Region: COG2308
634457005778	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
634457005779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
634457005780	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
634457005781	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
634457005782	dimerization interface [polypeptide binding]; other site
634457005783	active site
634457005784	quinolinate synthetase; Provisional; Region: PRK09375
634457005785	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
634457005786	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634457005787	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634457005788	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
634457005789	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634457005790	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634457005791	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634457005792	NAD(P) binding site [chemical binding]; other site
634457005793	catalytic residues [active]
634457005794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457005795	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634457005796	putative substrate translocation pore; other site
634457005797	Domain of unknown function (DUF336); Region: DUF336; pfam03928
634457005798	Predicted flavoprotein [General function prediction only]; Region: COG0431
634457005799	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
634457005800	Pirin-related protein [General function prediction only]; Region: COG1741
634457005801	Pirin; Region: Pirin; pfam02678
634457005802	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
634457005803	LysR family transcriptional regulator; Provisional; Region: PRK14997
634457005804	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457005805	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
634457005806	putative effector binding pocket; other site
634457005807	putative dimerization interface [polypeptide binding]; other site
634457005808	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634457005809	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634457005810	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634457005811	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634457005812	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
634457005813	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634457005814	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457005815	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634457005816	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457005817	D-galactonate transporter; Region: 2A0114; TIGR00893
634457005818	putative substrate translocation pore; other site
634457005819	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634457005820	EamA-like transporter family; Region: EamA; cl17759
634457005821	EamA-like transporter family; Region: EamA; pfam00892
634457005822	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
634457005823	putative active site [active]
634457005824	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
634457005825	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
634457005826	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
634457005827	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
634457005828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457005829	NAD(P) binding site [chemical binding]; other site
634457005830	active site
634457005831	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
634457005832	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
634457005833	carboxyltransferase (CT) interaction site; other site
634457005834	biotinylation site [posttranslational modification]; other site
634457005835	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
634457005836	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634457005837	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
634457005838	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
634457005839	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
634457005840	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
634457005841	carboxyltransferase (CT) interaction site; other site
634457005842	biotinylation site [posttranslational modification]; other site
634457005843	aspartate aminotransferase; Provisional; Region: PRK05764
634457005844	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634457005845	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457005846	homodimer interface [polypeptide binding]; other site
634457005847	catalytic residue [active]
634457005848	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
634457005849	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457005850	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
634457005851	putative dimerization interface [polypeptide binding]; other site
634457005852	amidase; Provisional; Region: PRK07056
634457005853	Amidase; Region: Amidase; cl11426
634457005854	short chain dehydrogenase; Provisional; Region: PRK09291
634457005855	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457005856	NAD(P) binding site [chemical binding]; other site
634457005857	active site
634457005858	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
634457005859	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
634457005860	active site
634457005861	catalytic site [active]
634457005862	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
634457005863	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
634457005864	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
634457005865	catalytic site [active]
634457005866	active site
634457005867	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
634457005868	glycogen branching enzyme; Provisional; Region: PRK05402
634457005869	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
634457005870	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
634457005871	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
634457005872	active site
634457005873	catalytic site [active]
634457005874	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
634457005875	glycogen synthase; Provisional; Region: glgA; PRK00654
634457005876	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
634457005877	ADP-binding pocket [chemical binding]; other site
634457005878	homodimer interface [polypeptide binding]; other site
634457005879	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
634457005880	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
634457005881	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
634457005882	active site
634457005883	catalytic site [active]
634457005884	short chain dehydrogenase; Provisional; Region: PRK06701
634457005885	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457005886	NAD(P) binding site [chemical binding]; other site
634457005887	active site
634457005888	thiamine pyrophosphate protein; Provisional; Region: PRK08273
634457005889	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
634457005890	PYR/PP interface [polypeptide binding]; other site
634457005891	dimer interface [polypeptide binding]; other site
634457005892	tetramer interface [polypeptide binding]; other site
634457005893	TPP binding site [chemical binding]; other site
634457005894	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634457005895	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
634457005896	TPP-binding site [chemical binding]; other site
634457005897	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634457005898	Transposase; Region: HTH_Tnp_1; pfam01527
634457005899	HTH-like domain; Region: HTH_21; pfam13276
634457005900	Integrase core domain; Region: rve; pfam00665
634457005901	Integrase core domain; Region: rve_3; pfam13683
634457005902	FAD binding domain; Region: FAD_binding_3; pfam01494
634457005903	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
634457005904	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
634457005905	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
634457005906	Cu(I) binding site [ion binding]; other site
634457005907	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634457005908	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634457005909	N-terminal plug; other site
634457005910	ligand-binding site [chemical binding]; other site
634457005911	Hint domain; Region: Hint_2; pfam13403
634457005912	HTH-like domain; Region: HTH_21; pfam13276
634457005913	Integrase core domain; Region: rve; pfam00665
634457005914	Integrase core domain; Region: rve_3; pfam13683
634457005915	Transposase; Region: HTH_Tnp_1; pfam01527
634457005916	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
634457005917	nudix motif; other site
634457005918	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457005919	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634457005920	dimerization interface [polypeptide binding]; other site
634457005921	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634457005922	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634457005923	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
634457005924	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
634457005925	Zinc-finger domain; Region: zf-CHCC; pfam10276
634457005926	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
634457005927	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
634457005928	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
634457005929	DsbD alpha interface [polypeptide binding]; other site
634457005930	catalytic residues [active]
634457005931	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
634457005932	seryl-tRNA synthetase; Provisional; Region: PRK05431
634457005933	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
634457005934	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
634457005935	dimer interface [polypeptide binding]; other site
634457005936	active site
634457005937	motif 1; other site
634457005938	motif 2; other site
634457005939	motif 3; other site
634457005940	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
634457005941	sec-independent translocase; Provisional; Region: tatB; PRK00182
634457005942	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
634457005943	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
634457005944	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
634457005945	Sporulation related domain; Region: SPOR; pfam05036
634457005946	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
634457005947	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
634457005948	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634457005949	active site
634457005950	HIGH motif; other site
634457005951	nucleotide binding site [chemical binding]; other site
634457005952	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
634457005953	KMSK motif region; other site
634457005954	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
634457005955	tRNA binding surface [nucleotide binding]; other site
634457005956	anticodon binding site; other site
634457005957	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
634457005958	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
634457005959	Zn2+ binding site [ion binding]; other site
634457005960	Mg2+ binding site [ion binding]; other site
634457005961	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
634457005962	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
634457005963	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
634457005964	putative catalytic site [active]
634457005965	putative phosphate binding site [ion binding]; other site
634457005966	active site
634457005967	metal binding site A [ion binding]; metal-binding site
634457005968	DNA binding site [nucleotide binding]
634457005969	putative AP binding site [nucleotide binding]; other site
634457005970	putative metal binding site B [ion binding]; other site
634457005971	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634457005972	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634457005973	active site
634457005974	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
634457005975	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
634457005976	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
634457005977	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
634457005978	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
634457005979	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
634457005980	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
634457005981	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
634457005982	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
634457005983	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
634457005984	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457005985	FeS/SAM binding site; other site
634457005986	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
634457005987	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
634457005988	dinuclear metal binding motif [ion binding]; other site
634457005989	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
634457005990	Clp protease; Region: CLP_protease; pfam00574
634457005991	oligomer interface [polypeptide binding]; other site
634457005992	active site residues [active]
634457005993	aminotransferase; Validated; Region: PRK09148
634457005994	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634457005995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457005996	homodimer interface [polypeptide binding]; other site
634457005997	catalytic residue [active]
634457005998	homoserine dehydrogenase; Provisional; Region: PRK06349
634457005999	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
634457006000	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
634457006001	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
634457006002	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
634457006003	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
634457006004	putative active site [active]
634457006005	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
634457006006	DHH family; Region: DHH; pfam01368
634457006007	DHHA1 domain; Region: DHHA1; pfam02272
634457006008	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
634457006009	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634457006010	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634457006011	DNA binding residues [nucleotide binding]
634457006012	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
634457006013	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634457006014	RNA binding surface [nucleotide binding]; other site
634457006015	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
634457006016	active site
634457006017	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
634457006018	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
634457006019	ABC-ATPase subunit  interface; other site
634457006020	dimer interface [polypeptide binding]; other site
634457006021	putative PBP binding regions; other site
634457006022	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
634457006023	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
634457006024	Walker A/P-loop; other site
634457006025	ATP binding site [chemical binding]; other site
634457006026	Q-loop/lid; other site
634457006027	ABC transporter signature motif; other site
634457006028	Walker B; other site
634457006029	D-loop; other site
634457006030	H-loop/switch region; other site
634457006031	Uncharacterized conserved protein [Function unknown]; Region: COG0397
634457006032	hypothetical protein; Validated; Region: PRK00029
634457006033	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
634457006034	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
634457006035	homodimer interface [polypeptide binding]; other site
634457006036	substrate-cofactor binding pocket; other site
634457006037	catalytic residue [active]
634457006038	DNA polymerase I; Provisional; Region: PRK05755
634457006039	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
634457006040	active site
634457006041	metal binding site 1 [ion binding]; metal-binding site
634457006042	putative 5' ssDNA interaction site; other site
634457006043	metal binding site 3; metal-binding site
634457006044	metal binding site 2 [ion binding]; metal-binding site
634457006045	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
634457006046	putative DNA binding site [nucleotide binding]; other site
634457006047	putative metal binding site [ion binding]; other site
634457006048	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
634457006049	active site
634457006050	catalytic site [active]
634457006051	substrate binding site [chemical binding]; other site
634457006052	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
634457006053	active site
634457006054	DNA binding site [nucleotide binding]
634457006055	catalytic site [active]
634457006056	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
634457006057	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
634457006058	Cu(I) binding site [ion binding]; other site
634457006059	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
634457006060	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
634457006061	putative acyl-acceptor binding pocket; other site
634457006062	proline/glycine betaine transporter; Provisional; Region: PRK10642
634457006063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457006064	putative substrate translocation pore; other site
634457006065	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457006066	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457006067	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
634457006068	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
634457006069	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
634457006070	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
634457006071	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
634457006072	L-asparagine permease; Provisional; Region: PRK15049
634457006073	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
634457006074	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
634457006075	Trp docking motif [polypeptide binding]; other site
634457006076	putative active site [active]
634457006077	Hint domain; Region: Hint_2; pfam13403
634457006078	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
634457006079	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
634457006080	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634457006081	inhibitor-cofactor binding pocket; inhibition site
634457006082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457006083	catalytic residue [active]
634457006084	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
634457006085	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634457006086	DNA-binding site [nucleotide binding]; DNA binding site
634457006087	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634457006088	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457006089	homodimer interface [polypeptide binding]; other site
634457006090	catalytic residue [active]
634457006091	allantoate amidohydrolase; Reviewed; Region: PRK09290
634457006092	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
634457006093	active site
634457006094	metal binding site [ion binding]; metal-binding site
634457006095	dimer interface [polypeptide binding]; other site
634457006096	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
634457006097	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
634457006098	homodimer interface [polypeptide binding]; other site
634457006099	active site
634457006100	FMN binding site [chemical binding]; other site
634457006101	substrate binding site [chemical binding]; other site
634457006102	4Fe-4S binding domain; Region: Fer4; pfam00037
634457006103	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
634457006104	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
634457006105	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634457006106	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634457006107	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634457006108	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634457006109	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634457006110	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634457006111	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634457006112	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634457006113	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634457006114	Transposase; Region: HTH_Tnp_1; pfam01527
634457006115	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634457006116	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457006117	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
634457006118	phenylhydantoinase; Validated; Region: PRK08323
634457006119	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
634457006120	tetramer interface [polypeptide binding]; other site
634457006121	active site
634457006122	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634457006123	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
634457006124	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
634457006125	putative substrate binding site [chemical binding]; other site
634457006126	Na binding site [ion binding]; other site
634457006127	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634457006128	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
634457006129	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
634457006130	active site
634457006131	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
634457006132	active site
634457006133	dimer interface [polypeptide binding]; other site
634457006134	Preprotein translocase subunit SecB; Region: SecB; pfam02556
634457006135	SecA binding site; other site
634457006136	Preprotein binding site; other site
634457006137	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
634457006138	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
634457006139	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
634457006140	active site
634457006141	hydrophilic channel; other site
634457006142	catalytic residues [active]
634457006143	active site lid [active]
634457006144	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
634457006145	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
634457006146	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
634457006147	Na binding site [ion binding]; other site
634457006148	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
634457006149	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
634457006150	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
634457006151	Beta-lactamase; Region: Beta-lactamase; pfam00144
634457006152	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634457006153	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634457006154	non-specific DNA binding site [nucleotide binding]; other site
634457006155	salt bridge; other site
634457006156	sequence-specific DNA binding site [nucleotide binding]; other site
634457006157	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
634457006158	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
634457006159	heme-binding site [chemical binding]; other site
634457006160	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
634457006161	FAD binding pocket [chemical binding]; other site
634457006162	FAD binding motif [chemical binding]; other site
634457006163	phosphate binding motif [ion binding]; other site
634457006164	beta-alpha-beta structure motif; other site
634457006165	NAD binding pocket [chemical binding]; other site
634457006166	Heme binding  pocket [chemical binding]; other site
634457006167	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457006168	dimer interface [polypeptide binding]; other site
634457006169	conserved gate region; other site
634457006170	putative PBP binding loops; other site
634457006171	ABC-ATPase subunit interface; other site
634457006172	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
634457006173	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
634457006174	Walker A/P-loop; other site
634457006175	ATP binding site [chemical binding]; other site
634457006176	Q-loop/lid; other site
634457006177	ABC transporter signature motif; other site
634457006178	Walker B; other site
634457006179	D-loop; other site
634457006180	H-loop/switch region; other site
634457006181	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
634457006182	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
634457006183	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
634457006184	FAD binding domain; Region: FAD_binding_4; pfam01565
634457006185	siroheme synthase; Provisional; Region: cysG; PRK10637
634457006186	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
634457006187	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
634457006188	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
634457006189	active site
634457006190	SAM binding site [chemical binding]; other site
634457006191	homodimer interface [polypeptide binding]; other site
634457006192	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634457006193	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634457006194	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
634457006195	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
634457006196	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
634457006197	Amidase; Region: Amidase; cl11426
634457006198	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
634457006199	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
634457006200	intersubunit interface [polypeptide binding]; other site
634457006201	active site
634457006202	Zn2+ binding site [ion binding]; other site
634457006203	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
634457006204	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
634457006205	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
634457006206	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
634457006207	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
634457006208	FMN-binding pocket [chemical binding]; other site
634457006209	flavin binding motif; other site
634457006210	phosphate binding motif [ion binding]; other site
634457006211	beta-alpha-beta structure motif; other site
634457006212	NAD binding pocket [chemical binding]; other site
634457006213	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634457006214	catalytic loop [active]
634457006215	iron binding site [ion binding]; other site
634457006216	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
634457006217	classical (c) SDRs; Region: SDR_c; cd05233
634457006218	NAD(P) binding site [chemical binding]; other site
634457006219	active site
634457006220	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
634457006221	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634457006222	[2Fe-2S] cluster binding site [ion binding]; other site
634457006223	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
634457006224	putative alpha subunit interface [polypeptide binding]; other site
634457006225	putative active site [active]
634457006226	putative substrate binding site [chemical binding]; other site
634457006227	Fe binding site [ion binding]; other site
634457006228	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634457006229	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634457006230	active site
634457006231	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
634457006232	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
634457006233	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634457006234	NAD(P) binding site [chemical binding]; other site
634457006235	catalytic residues [active]
634457006236	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
634457006237	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
634457006238	Trp docking motif [polypeptide binding]; other site
634457006239	cytochrome domain interface [polypeptide binding]; other site
634457006240	active site
634457006241	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634457006242	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457006243	putative substrate translocation pore; other site
634457006244	SnoaL-like domain; Region: SnoaL_4; pfam13577
634457006245	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457006246	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457006247	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
634457006248	putative substrate binding pocket [chemical binding]; other site
634457006249	dimerization interface [polypeptide binding]; other site
634457006250	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
634457006251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457006252	dimer interface [polypeptide binding]; other site
634457006253	conserved gate region; other site
634457006254	putative PBP binding loops; other site
634457006255	ABC-ATPase subunit interface; other site
634457006256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457006257	ABC-ATPase subunit interface; other site
634457006258	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457006259	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457006260	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457006261	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
634457006262	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
634457006263	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
634457006264	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
634457006265	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457006266	Walker A/P-loop; other site
634457006267	ATP binding site [chemical binding]; other site
634457006268	Q-loop/lid; other site
634457006269	ABC transporter signature motif; other site
634457006270	Walker B; other site
634457006271	D-loop; other site
634457006272	H-loop/switch region; other site
634457006273	TOBE domain; Region: TOBE_2; pfam08402
634457006274	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
634457006275	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
634457006276	tetrameric interface [polypeptide binding]; other site
634457006277	NAD binding site [chemical binding]; other site
634457006278	catalytic residues [active]
634457006279	substrate binding site [chemical binding]; other site
634457006280	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
634457006281	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
634457006282	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634457006283	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
634457006284	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634457006285	Sel1-like repeats; Region: SEL1; smart00671
634457006286	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634457006287	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634457006288	N-terminal plug; other site
634457006289	ligand-binding site [chemical binding]; other site
634457006290	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
634457006291	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634457006292	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
634457006293	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
634457006294	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634457006295	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457006296	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457006297	LysR substrate binding domain; Region: LysR_substrate; pfam03466
634457006298	dimerization interface [polypeptide binding]; other site
634457006299	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634457006300	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634457006301	[2Fe-2S] cluster binding site [ion binding]; other site
634457006302	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
634457006303	hydrophobic ligand binding site; other site
634457006304	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
634457006305	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
634457006306	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634457006307	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
634457006308	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
634457006309	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
634457006310	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
634457006311	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634457006312	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634457006313	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634457006314	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
634457006315	tetramerization interface [polypeptide binding]; other site
634457006316	NAD(P) binding site [chemical binding]; other site
634457006317	catalytic residues [active]
634457006318	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
634457006319	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457006320	putative substrate translocation pore; other site
634457006321	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
634457006322	homotrimer interface [polypeptide binding]; other site
634457006323	Walker A motif; other site
634457006324	GTP binding site [chemical binding]; other site
634457006325	Walker B motif; other site
634457006326	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
634457006327	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
634457006328	putative dimer interface [polypeptide binding]; other site
634457006329	active site pocket [active]
634457006330	putative cataytic base [active]
634457006331	cobalamin synthase; Reviewed; Region: cobS; PRK00235
634457006332	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
634457006333	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634457006334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457006335	homodimer interface [polypeptide binding]; other site
634457006336	catalytic residue [active]
634457006337	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
634457006338	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
634457006339	putative FMN binding site [chemical binding]; other site
634457006340	cobyric acid synthase; Provisional; Region: PRK00784
634457006341	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
634457006342	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
634457006343	catalytic triad [active]
634457006344	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
634457006345	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
634457006346	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
634457006347	homodimer interface [polypeptide binding]; other site
634457006348	Walker A motif; other site
634457006349	ATP binding site [chemical binding]; other site
634457006350	hydroxycobalamin binding site [chemical binding]; other site
634457006351	Walker B motif; other site
634457006352	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634457006353	catalytic core [active]
634457006354	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
634457006355	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634457006356	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634457006357	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
634457006358	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
634457006359	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
634457006360	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
634457006361	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
634457006362	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
634457006363	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
634457006364	dimer interface [polypeptide binding]; other site
634457006365	[2Fe-2S] cluster binding site [ion binding]; other site
634457006366	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
634457006367	MarR family; Region: MarR; pfam01047
634457006368	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634457006369	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634457006370	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
634457006371	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
634457006372	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
634457006373	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
634457006374	substrate binding site [chemical binding]; other site
634457006375	oxyanion hole (OAH) forming residues; other site
634457006376	trimer interface [polypeptide binding]; other site
634457006377	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
634457006378	Flavin Reductases; Region: FlaRed; cl00801
634457006379	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
634457006380	dimer interface [polypeptide binding]; other site
634457006381	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
634457006382	putative PBP binding regions; other site
634457006383	ABC-ATPase subunit  interface; other site
634457006384	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
634457006385	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457006386	Walker A/P-loop; other site
634457006387	ATP binding site [chemical binding]; other site
634457006388	Q-loop/lid; other site
634457006389	ABC transporter signature motif; other site
634457006390	Walker B; other site
634457006391	D-loop; other site
634457006392	H-loop/switch region; other site
634457006393	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634457006394	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
634457006395	intersubunit interface [polypeptide binding]; other site
634457006396	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
634457006397	metal binding site 2 [ion binding]; metal-binding site
634457006398	putative DNA binding helix; other site
634457006399	metal binding site 1 [ion binding]; metal-binding site
634457006400	dimer interface [polypeptide binding]; other site
634457006401	structural Zn2+ binding site [ion binding]; other site
634457006402	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
634457006403	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
634457006404	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
634457006405	putative deacylase active site [active]
634457006406	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030
634457006407	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
634457006408	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
634457006409	dimer interface [polypeptide binding]; other site
634457006410	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457006411	catalytic residue [active]
634457006412	GMP synthase; Reviewed; Region: guaA; PRK00074
634457006413	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
634457006414	AMP/PPi binding site [chemical binding]; other site
634457006415	candidate oxyanion hole; other site
634457006416	catalytic triad [active]
634457006417	potential glutamine specificity residues [chemical binding]; other site
634457006418	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
634457006419	ATP Binding subdomain [chemical binding]; other site
634457006420	Ligand Binding sites [chemical binding]; other site
634457006421	Dimerization subdomain; other site
634457006422	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634457006423	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634457006424	catalytic residues [active]
634457006425	catalytic nucleophile [active]
634457006426	Presynaptic Site I dimer interface [polypeptide binding]; other site
634457006427	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634457006428	Synaptic Flat tetramer interface [polypeptide binding]; other site
634457006429	Synaptic Site I dimer interface [polypeptide binding]; other site
634457006430	DNA binding site [nucleotide binding]
634457006431	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634457006432	DNA-binding interface [nucleotide binding]; DNA binding site
634457006433	Domain of unknown function (DUF927); Region: DUF927; pfam06048
634457006434	Toprim domain; Region: Toprim_3; pfam13362
634457006435	Helix-turn-helix domain; Region: HTH_17; pfam12728
634457006436	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457006437	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457006438	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457006439	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634457006440	salt bridge; other site
634457006441	non-specific DNA binding site [nucleotide binding]; other site
634457006442	sequence-specific DNA binding site [nucleotide binding]; other site
634457006443	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457006444	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457006445	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
634457006446	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
634457006447	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
634457006448	DNA binding residues [nucleotide binding]
634457006449	HNH endonuclease; Region: HNH_2; pfam13391
634457006450	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457006451	active site
634457006452	DNA binding site [nucleotide binding]
634457006453	Int/Topo IB signature motif; other site
634457006454	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634457006455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457006456	putative substrate translocation pore; other site
634457006457	Phage shock protein B; Region: PspB; cl05946
634457006458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457006459	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634457006460	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634457006461	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634457006462	catalytic residue [active]
634457006463	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
634457006464	L-lactate permease; Region: Lactate_perm; cl00701
634457006465	Uncharacterized conserved protein [Function unknown]; Region: COG1359
634457006466	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
634457006467	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
634457006468	NADP binding site [chemical binding]; other site
634457006469	homopentamer interface [polypeptide binding]; other site
634457006470	substrate binding site [chemical binding]; other site
634457006471	active site
634457006472	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
634457006473	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
634457006474	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
634457006475	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
634457006476	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634457006477	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634457006478	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634457006479	catalytic residue [active]
634457006480	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
634457006481	Sporulation related domain; Region: SPOR; pfam05036
634457006482	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
634457006483	ABC-2 type transporter; Region: ABC2_membrane; cl17235
634457006484	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
634457006485	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
634457006486	Walker A/P-loop; other site
634457006487	ATP binding site [chemical binding]; other site
634457006488	Q-loop/lid; other site
634457006489	ABC transporter signature motif; other site
634457006490	Walker B; other site
634457006491	D-loop; other site
634457006492	H-loop/switch region; other site
634457006493	Uncharacterized conserved protein [Function unknown]; Region: COG1742
634457006494	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
634457006495	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
634457006496	Cl binding site [ion binding]; other site
634457006497	oligomer interface [polypeptide binding]; other site
634457006498	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
634457006499	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634457006500	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457006501	homodimer interface [polypeptide binding]; other site
634457006502	catalytic residue [active]
634457006503	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
634457006504	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
634457006505	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
634457006506	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
634457006507	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
634457006508	TPP-binding site [chemical binding]; other site
634457006509	dimer interface [polypeptide binding]; other site
634457006510	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634457006511	PYR/PP interface [polypeptide binding]; other site
634457006512	dimer interface [polypeptide binding]; other site
634457006513	TPP binding site [chemical binding]; other site
634457006514	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634457006515	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
634457006516	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
634457006517	putative active site [active]
634457006518	catalytic residue [active]
634457006519	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
634457006520	SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798
634457006521	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
634457006522	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
634457006523	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634457006524	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
634457006525	active site
634457006526	motif I; other site
634457006527	motif II; other site
634457006528	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
634457006529	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
634457006530	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
634457006531	putative active site [active]
634457006532	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
634457006533	tetramer (dimer of dimers) interface [polypeptide binding]; other site
634457006534	active site
634457006535	dimer interface [polypeptide binding]; other site
634457006536	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
634457006537	AAA domain; Region: AAA_33; pfam13671
634457006538	ATP-binding site [chemical binding]; other site
634457006539	Gluconate-6-phosphate binding site [chemical binding]; other site
634457006540	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
634457006541	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634457006542	intersubunit interface [polypeptide binding]; other site
634457006543	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
634457006544	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
634457006545	Cl- selectivity filter; other site
634457006546	Cl- binding residues [ion binding]; other site
634457006547	pore gating glutamate residue; other site
634457006548	dimer interface [polypeptide binding]; other site
634457006549	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
634457006550	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
634457006551	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
634457006552	NAD(P) binding site [chemical binding]; other site
634457006553	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
634457006554	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634457006555	catalytic residue [active]
634457006556	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
634457006557	potassium uptake protein; Region: kup; TIGR00794
634457006558	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
634457006559	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457006560	FeS/SAM binding site; other site
634457006561	HemN C-terminal domain; Region: HemN_C; pfam06969
634457006562	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
634457006563	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
634457006564	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
634457006565	Walker A/P-loop; other site
634457006566	ATP binding site [chemical binding]; other site
634457006567	Q-loop/lid; other site
634457006568	ABC transporter signature motif; other site
634457006569	Walker B; other site
634457006570	D-loop; other site
634457006571	H-loop/switch region; other site
634457006572	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
634457006573	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
634457006574	Walker A/P-loop; other site
634457006575	ATP binding site [chemical binding]; other site
634457006576	Q-loop/lid; other site
634457006577	ABC transporter signature motif; other site
634457006578	Walker B; other site
634457006579	D-loop; other site
634457006580	H-loop/switch region; other site
634457006581	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
634457006582	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
634457006583	TM-ABC transporter signature motif; other site
634457006584	HEAT repeats; Region: HEAT_2; pfam13646
634457006585	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
634457006586	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
634457006587	TM-ABC transporter signature motif; other site
634457006588	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
634457006589	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
634457006590	putative ligand binding site [chemical binding]; other site
634457006591	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634457006592	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634457006593	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634457006594	dimer interface [polypeptide binding]; other site
634457006595	phosphorylation site [posttranslational modification]
634457006596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457006597	ATP binding site [chemical binding]; other site
634457006598	Mg2+ binding site [ion binding]; other site
634457006599	G-X-G motif; other site
634457006600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457006601	Response regulator receiver domain; Region: Response_reg; pfam00072
634457006602	active site
634457006603	phosphorylation site [posttranslational modification]
634457006604	intermolecular recognition site; other site
634457006605	dimerization interface [polypeptide binding]; other site
634457006606	Response regulator receiver domain; Region: Response_reg; pfam00072
634457006607	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457006608	active site
634457006609	phosphorylation site [posttranslational modification]
634457006610	intermolecular recognition site; other site
634457006611	dimerization interface [polypeptide binding]; other site
634457006612	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
634457006613	DNA binding residues [nucleotide binding]
634457006614	HTH-like domain; Region: HTH_21; pfam13276
634457006615	Integrase core domain; Region: rve; pfam00665
634457006616	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457006617	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634457006618	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
634457006619	UreF; Region: UreF; pfam01730
634457006620	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
634457006621	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
634457006622	dimer interface [polypeptide binding]; other site
634457006623	catalytic residues [active]
634457006624	urease subunit alpha; Reviewed; Region: ureC; PRK13207
634457006625	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
634457006626	subunit interactions [polypeptide binding]; other site
634457006627	active site
634457006628	flap region; other site
634457006629	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
634457006630	alpha-beta subunit interface [polypeptide binding]; other site
634457006631	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
634457006632	alpha-gamma subunit interface [polypeptide binding]; other site
634457006633	beta-gamma subunit interface [polypeptide binding]; other site
634457006634	UreD urease accessory protein; Region: UreD; pfam01774
634457006635	High-affinity nickel-transport protein; Region: NicO; cl00964
634457006636	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
634457006637	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
634457006638	dimer interface [polypeptide binding]; other site
634457006639	PYR/PP interface [polypeptide binding]; other site
634457006640	TPP binding site [chemical binding]; other site
634457006641	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634457006642	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
634457006643	TPP-binding site [chemical binding]; other site
634457006644	dimer interface [polypeptide binding]; other site
634457006645	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
634457006646	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
634457006647	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
634457006648	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
634457006649	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
634457006650	heme binding site [chemical binding]; other site
634457006651	ferroxidase pore; other site
634457006652	ferroxidase diiron center [ion binding]; other site
634457006653	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
634457006654	ArsC family; Region: ArsC; pfam03960
634457006655	putative catalytic residues [active]
634457006656	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
634457006657	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
634457006658	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634457006659	dimerization interface [polypeptide binding]; other site
634457006660	putative DNA binding site [nucleotide binding]; other site
634457006661	putative Zn2+ binding site [ion binding]; other site
634457006662	peroxiredoxin; Provisional; Region: PRK13189
634457006663	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634457006664	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
634457006665	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
634457006666	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
634457006667	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
634457006668	Sulfate transporter family; Region: Sulfate_transp; pfam00916
634457006669	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
634457006670	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
634457006671	catalytic residues [active]
634457006672	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457006673	Pirin-related protein [General function prediction only]; Region: COG1741
634457006674	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634457006675	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
634457006676	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634457006677	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457006678	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634457006679	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457006680	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457006681	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457006682	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
634457006683	putative dimerization interface [polypeptide binding]; other site
634457006684	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457006685	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634457006686	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
634457006687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457006688	putative substrate translocation pore; other site
634457006689	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457006690	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457006691	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
634457006692	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634457006693	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
634457006694	Isochorismatase family; Region: Isochorismatase; pfam00857
634457006695	catalytic triad [active]
634457006696	conserved cis-peptide bond; other site
634457006697	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
634457006698	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634457006699	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634457006700	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634457006701	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
634457006702	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634457006703	Cytochrome c; Region: Cytochrom_C; pfam00034
634457006704	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634457006705	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634457006706	Cytochrome c; Region: Cytochrom_C; pfam00034
634457006707	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
634457006708	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
634457006709	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634457006710	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
634457006711	Transcriptional regulators [Transcription]; Region: MarR; COG1846
634457006712	MarR family; Region: MarR_2; pfam12802
634457006713	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457006714	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
634457006715	active site
634457006716	catalytic triad [active]
634457006717	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457006718	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
634457006719	Walker A motif; other site
634457006720	ATP binding site [chemical binding]; other site
634457006721	Walker B motif; other site
634457006722	arginine finger; other site
634457006723	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
634457006724	putative transposase OrfB; Reviewed; Region: PHA02517
634457006725	HTH-like domain; Region: HTH_21; pfam13276
634457006726	Integrase core domain; Region: rve; pfam00665
634457006727	Integrase core domain; Region: rve_3; pfam13683
634457006728	Transposase; Region: HTH_Tnp_1; cl17663
634457006729	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
634457006730	conjugal transfer protein TrbF; Provisional; Region: PRK13872
634457006731	conjugal transfer protein TrbL; Provisional; Region: PRK13875
634457006732	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
634457006733	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457006734	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634457006735	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
634457006736	catalytic residues [active]
634457006737	catalytic nucleophile [active]
634457006738	Recombinase; Region: Recombinase; pfam07508
634457006739	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634457006740	non-specific DNA binding site [nucleotide binding]; other site
634457006741	salt bridge; other site
634457006742	sequence-specific DNA binding site [nucleotide binding]; other site
634457006743	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
634457006744	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457006745	putative transposase OrfB; Reviewed; Region: PHA02517
634457006746	HTH-like domain; Region: HTH_21; pfam13276
634457006747	Integrase core domain; Region: rve; pfam00665
634457006748	Integrase core domain; Region: rve_3; pfam13683
634457006749	Transposase; Region: HTH_Tnp_1; cl17663
634457006750	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
634457006751	Replication initiator protein A; Region: RPA; pfam10134
634457006752	putative transposase OrfB; Reviewed; Region: PHA02517
634457006753	HTH-like domain; Region: HTH_21; pfam13276
634457006754	Integrase core domain; Region: rve; pfam00665
634457006755	Integrase core domain; Region: rve_3; pfam13683
634457006756	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457006757	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457006758	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
634457006759	NAD(P) binding site [chemical binding]; other site
634457006760	active site
634457006761	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
634457006762	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
634457006763	Protein required for attachment to host cells; Region: Host_attach; pfam10116
634457006764	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
634457006765	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
634457006766	XdhC Rossmann domain; Region: XdhC_C; pfam13478
634457006767	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
634457006768	Ligand binding site; other site
634457006769	metal-binding site
634457006770	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
634457006771	homotrimer interaction site [polypeptide binding]; other site
634457006772	putative active site [active]
634457006773	CHAP domain; Region: CHAP; cl17642
634457006774	glycine dehydrogenase; Provisional; Region: PRK05367
634457006775	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
634457006776	tetramer interface [polypeptide binding]; other site
634457006777	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457006778	catalytic residue [active]
634457006779	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
634457006780	tetramer interface [polypeptide binding]; other site
634457006781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457006782	catalytic residue [active]
634457006783	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
634457006784	lipoyl attachment site [posttranslational modification]; other site
634457006785	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
634457006786	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
634457006787	spermidine synthase; Provisional; Region: PRK00811
634457006788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457006789	S-adenosylmethionine binding site [chemical binding]; other site
634457006790	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
634457006791	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457006792	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457006793	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634457006794	putative effector binding pocket; other site
634457006795	dimerization interface [polypeptide binding]; other site
634457006796	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
634457006797	active site
634457006798	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
634457006799	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
634457006800	active site
634457006801	(T/H)XGH motif; other site
634457006802	DNA gyrase, A subunit; Region: gyrA; TIGR01063
634457006803	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
634457006804	CAP-like domain; other site
634457006805	active site
634457006806	primary dimer interface [polypeptide binding]; other site
634457006807	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634457006808	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634457006809	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634457006810	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634457006811	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
634457006812	FMN binding site [chemical binding]; other site
634457006813	substrate binding site [chemical binding]; other site
634457006814	putative catalytic residue [active]
634457006815	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
634457006816	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
634457006817	RNase E interface [polypeptide binding]; other site
634457006818	trimer interface [polypeptide binding]; other site
634457006819	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
634457006820	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
634457006821	RNase E interface [polypeptide binding]; other site
634457006822	trimer interface [polypeptide binding]; other site
634457006823	active site
634457006824	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
634457006825	putative nucleic acid binding region [nucleotide binding]; other site
634457006826	G-X-X-G motif; other site
634457006827	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
634457006828	RNA binding site [nucleotide binding]; other site
634457006829	domain interface; other site
634457006830	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
634457006831	16S/18S rRNA binding site [nucleotide binding]; other site
634457006832	S13e-L30e interaction site [polypeptide binding]; other site
634457006833	25S rRNA binding site [nucleotide binding]; other site
634457006834	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
634457006835	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
634457006836	RNA binding site [nucleotide binding]; other site
634457006837	active site
634457006838	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
634457006839	Permease; Region: Permease; pfam02405
634457006840	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
634457006841	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
634457006842	Walker A/P-loop; other site
634457006843	ATP binding site [chemical binding]; other site
634457006844	Q-loop/lid; other site
634457006845	ABC transporter signature motif; other site
634457006846	Walker B; other site
634457006847	D-loop; other site
634457006848	H-loop/switch region; other site
634457006849	mce related protein; Region: MCE; pfam02470
634457006850	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
634457006851	Protein of unknown function (DUF330); Region: DUF330; pfam03886
634457006852	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457006853	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
634457006854	putative ADP-binding pocket [chemical binding]; other site
634457006855	Clostridial hydrophobic W; Region: ChW; cl02763
634457006856	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
634457006857	binding surface
634457006858	TPR motif; other site
634457006859	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634457006860	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634457006861	active site
634457006862	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634457006863	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457006864	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634457006865	Sel1-like repeats; Region: SEL1; smart00671
634457006866	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634457006867	Sel1-like repeats; Region: SEL1; smart00671
634457006868	Sel1-like repeats; Region: SEL1; smart00671
634457006869	Sel1 repeat; Region: Sel1; cl02723
634457006870	Sel1-like repeats; Region: SEL1; smart00671
634457006871	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
634457006872	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634457006873	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457006874	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
634457006875	putative active site [active]
634457006876	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
634457006877	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634457006878	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457006879	Walker A/P-loop; other site
634457006880	ATP binding site [chemical binding]; other site
634457006881	Q-loop/lid; other site
634457006882	ABC transporter signature motif; other site
634457006883	Walker B; other site
634457006884	D-loop; other site
634457006885	H-loop/switch region; other site
634457006886	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
634457006887	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
634457006888	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
634457006889	substrate binding pocket [chemical binding]; other site
634457006890	dimer interface [polypeptide binding]; other site
634457006891	inhibitor binding site; inhibition site
634457006892	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
634457006893	B12 binding site [chemical binding]; other site
634457006894	cobalt ligand [ion binding]; other site
634457006895	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
634457006896	Colicin V production protein; Region: Colicin_V; pfam02674
634457006897	amidophosphoribosyltransferase; Provisional; Region: PRK09123
634457006898	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
634457006899	active site
634457006900	tetramer interface [polypeptide binding]; other site
634457006901	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634457006902	active site
634457006903	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
634457006904	Protein of unknown function (DUF330); Region: DUF330; pfam03886
634457006905	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
634457006906	mce related protein; Region: MCE; pfam02470
634457006907	mce related protein; Region: MCE; pfam02470
634457006908	mce related protein; Region: MCE; pfam02470
634457006909	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
634457006910	Paraquat-inducible protein A; Region: PqiA; pfam04403
634457006911	Paraquat-inducible protein A; Region: PqiA; pfam04403
634457006912	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
634457006913	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
634457006914	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
634457006915	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634457006916	active site
634457006917	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
634457006918	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
634457006919	ATP synthase subunit C; Region: ATP-synt_C; cl00466
634457006920	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
634457006921	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
634457006922	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
634457006923	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
634457006924	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
634457006925	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634457006926	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
634457006927	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
634457006928	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457006929	FeS/SAM binding site; other site
634457006930	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
634457006931	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
634457006932	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
634457006933	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
634457006934	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
634457006935	dimer interface [polypeptide binding]; other site
634457006936	active site
634457006937	metal binding site [ion binding]; metal-binding site
634457006938	glutathione binding site [chemical binding]; other site
634457006939	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634457006940	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634457006941	ATP binding site [chemical binding]; other site
634457006942	Mg++ binding site [ion binding]; other site
634457006943	motif III; other site
634457006944	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634457006945	nucleotide binding region [chemical binding]; other site
634457006946	ATP-binding site [chemical binding]; other site
634457006947	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
634457006948	RNA binding site [nucleotide binding]; other site
634457006949	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
634457006950	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
634457006951	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
634457006952	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
634457006953	23S rRNA interface [nucleotide binding]; other site
634457006954	L3 interface [polypeptide binding]; other site
634457006955	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457006956	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
634457006957	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457006958	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
634457006959	PhoU domain; Region: PhoU; pfam01895
634457006960	PhoU domain; Region: PhoU; pfam01895
634457006961	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
634457006962	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
634457006963	Walker A/P-loop; other site
634457006964	ATP binding site [chemical binding]; other site
634457006965	Q-loop/lid; other site
634457006966	ABC transporter signature motif; other site
634457006967	Walker B; other site
634457006968	D-loop; other site
634457006969	H-loop/switch region; other site
634457006970	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
634457006971	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457006972	dimer interface [polypeptide binding]; other site
634457006973	conserved gate region; other site
634457006974	putative PBP binding loops; other site
634457006975	ABC-ATPase subunit interface; other site
634457006976	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
634457006977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457006978	dimer interface [polypeptide binding]; other site
634457006979	conserved gate region; other site
634457006980	putative PBP binding loops; other site
634457006981	ABC-ATPase subunit interface; other site
634457006982	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
634457006983	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
634457006984	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
634457006985	NADP binding site [chemical binding]; other site
634457006986	dimer interface [polypeptide binding]; other site
634457006987	Predicted membrane protein [Function unknown]; Region: COG1289
634457006988	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
634457006989	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
634457006990	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
634457006991	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634457006992	protein binding site [polypeptide binding]; other site
634457006993	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634457006994	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
634457006995	active site
634457006996	catalytic triad [active]
634457006997	oxyanion hole [active]
634457006998	OpgC protein; Region: OpgC_C; pfam10129
634457006999	Acyltransferase family; Region: Acyl_transf_3; pfam01757
634457007000	antiporter inner membrane protein; Provisional; Region: PRK11670
634457007001	Domain of unknown function DUF59; Region: DUF59; pfam01883
634457007002	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
634457007003	Walker A motif; other site
634457007004	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
634457007005	Stringent starvation protein B; Region: SspB; cl01120
634457007006	fumarate hydratase; Provisional; Region: PRK15389
634457007007	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
634457007008	Fumarase C-terminus; Region: Fumerase_C; pfam05683
634457007009	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
634457007010	dimer interface [polypeptide binding]; other site
634457007011	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
634457007012	metal binding site [ion binding]; metal-binding site
634457007013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
634457007014	AntA/AntB antirepressor; Region: AntA; cl01430
634457007015	Putative glucoamylase; Region: Glycoamylase; pfam10091
634457007016	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
634457007017	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634457007018	hydroxyglutarate oxidase; Provisional; Region: PRK11728
634457007019	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
634457007020	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
634457007021	active site
634457007022	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634457007023	dimer interface [polypeptide binding]; other site
634457007024	substrate binding site [chemical binding]; other site
634457007025	catalytic residues [active]
634457007026	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
634457007027	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634457007028	putative DNA binding site [nucleotide binding]; other site
634457007029	putative Zn2+ binding site [ion binding]; other site
634457007030	AsnC family; Region: AsnC_trans_reg; pfam01037
634457007031	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
634457007032	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
634457007033	translation initiation factor IF-2; Region: IF-2; TIGR00487
634457007034	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
634457007035	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
634457007036	G1 box; other site
634457007037	putative GEF interaction site [polypeptide binding]; other site
634457007038	GTP/Mg2+ binding site [chemical binding]; other site
634457007039	Switch I region; other site
634457007040	G2 box; other site
634457007041	G3 box; other site
634457007042	Switch II region; other site
634457007043	G4 box; other site
634457007044	G5 box; other site
634457007045	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
634457007046	Translation-initiation factor 2; Region: IF-2; pfam11987
634457007047	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
634457007048	hypothetical protein; Provisional; Region: PRK09190
634457007049	Protein of unknown function (DUF448); Region: DUF448; pfam04296
634457007050	putative RNA binding cleft [nucleotide binding]; other site
634457007051	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
634457007052	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
634457007053	NusA N-terminal domain; Region: NusA_N; pfam08529
634457007054	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
634457007055	RNA binding site [nucleotide binding]; other site
634457007056	homodimer interface [polypeptide binding]; other site
634457007057	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
634457007058	G-X-X-G motif; other site
634457007059	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
634457007060	G-X-X-G motif; other site
634457007061	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
634457007062	hypothetical protein; Provisional; Region: PRK14636
634457007063	Sm and related proteins; Region: Sm_like; cl00259
634457007064	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
634457007065	putative RNA binding site [nucleotide binding]; other site
634457007066	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
634457007067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457007068	Walker A motif; other site
634457007069	ATP binding site [chemical binding]; other site
634457007070	Walker B motif; other site
634457007071	arginine finger; other site
634457007072	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457007073	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457007074	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634457007075	putative effector binding pocket; other site
634457007076	dimerization interface [polypeptide binding]; other site
634457007077	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
634457007078	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
634457007079	substrate binding pocket [chemical binding]; other site
634457007080	membrane-bound complex binding site; other site
634457007081	hinge residues; other site
634457007082	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
634457007083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634457007084	dimer interface [polypeptide binding]; other site
634457007085	conserved gate region; other site
634457007086	putative PBP binding loops; other site
634457007087	ABC-ATPase subunit interface; other site
634457007088	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
634457007089	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457007090	Walker A/P-loop; other site
634457007091	ATP binding site [chemical binding]; other site
634457007092	Q-loop/lid; other site
634457007093	ABC transporter signature motif; other site
634457007094	Walker B; other site
634457007095	D-loop; other site
634457007096	H-loop/switch region; other site
634457007097	aconitate hydratase; Validated; Region: PRK09277
634457007098	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
634457007099	substrate binding site [chemical binding]; other site
634457007100	ligand binding site [chemical binding]; other site
634457007101	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
634457007102	substrate binding site [chemical binding]; other site
634457007103	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
634457007104	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457007105	Walker A/P-loop; other site
634457007106	ATP binding site [chemical binding]; other site
634457007107	Q-loop/lid; other site
634457007108	ABC transporter signature motif; other site
634457007109	Walker B; other site
634457007110	D-loop; other site
634457007111	H-loop/switch region; other site
634457007112	CcmB protein; Region: CcmB; pfam03379
634457007113	hypothetical protein; Provisional; Region: PRK10316
634457007114	YfdX protein; Region: YfdX; pfam10938
634457007115	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
634457007116	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
634457007117	dimer interface [polypeptide binding]; other site
634457007118	active site
634457007119	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634457007120	catalytic residues [active]
634457007121	substrate binding site [chemical binding]; other site
634457007122	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
634457007123	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
634457007124	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
634457007125	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
634457007126	Dehydroquinase class II; Region: DHquinase_II; pfam01220
634457007127	trimer interface [polypeptide binding]; other site
634457007128	active site
634457007129	dimer interface [polypeptide binding]; other site
634457007130	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
634457007131	carboxyltransferase (CT) interaction site; other site
634457007132	biotinylation site [posttranslational modification]; other site
634457007133	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
634457007134	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634457007135	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634457007136	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
634457007137	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634457007138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457007139	putative substrate translocation pore; other site
634457007140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457007141	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
634457007142	ThiC-associated domain; Region: ThiC-associated; pfam13667
634457007143	ThiC family; Region: ThiC; pfam01964
634457007144	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
634457007145	Iron permease FTR1 family; Region: FTR1; cl00475
634457007146	Fe2+ transport protein; Region: Iron_transport; cl01377
634457007147	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634457007148	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
634457007149	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
634457007150	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634457007151	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
634457007152	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457007153	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634457007154	dimerization interface [polypeptide binding]; other site
634457007155	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
634457007156	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634457007157	inhibitor-cofactor binding pocket; inhibition site
634457007158	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457007159	catalytic residue [active]
634457007160	Synuclein; Region: Synuclein; pfam01387
634457007161	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
634457007162	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
634457007163	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
634457007164	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
634457007165	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
634457007166	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
634457007167	GatB domain; Region: GatB_Yqey; smart00845
634457007168	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634457007169	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634457007170	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457007171	Walker A/P-loop; other site
634457007172	ATP binding site [chemical binding]; other site
634457007173	Q-loop/lid; other site
634457007174	ABC transporter signature motif; other site
634457007175	Walker B; other site
634457007176	D-loop; other site
634457007177	H-loop/switch region; other site
634457007178	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
634457007179	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
634457007180	minor groove reading motif; other site
634457007181	helix-hairpin-helix signature motif; other site
634457007182	substrate binding pocket [chemical binding]; other site
634457007183	active site
634457007184	ferrochelatase; Reviewed; Region: hemH; PRK00035
634457007185	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
634457007186	C-terminal domain interface [polypeptide binding]; other site
634457007187	active site
634457007188	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
634457007189	active site
634457007190	N-terminal domain interface [polypeptide binding]; other site
634457007191	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
634457007192	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
634457007193	minor groove reading motif; other site
634457007194	helix-hairpin-helix signature motif; other site
634457007195	substrate binding pocket [chemical binding]; other site
634457007196	active site
634457007197	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
634457007198	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
634457007199	DNA binding and oxoG recognition site [nucleotide binding]
634457007200	Protein of unknown function (DUF721); Region: DUF721; cl02324
634457007201	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634457007202	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634457007203	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634457007204	catalytic residue [active]
634457007205	Sporulation related domain; Region: SPOR; cl10051
634457007206	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
634457007207	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
634457007208	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
634457007209	HIGH motif; other site
634457007210	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
634457007211	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634457007212	active site
634457007213	KMSKS motif; other site
634457007214	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
634457007215	tRNA binding surface [nucleotide binding]; other site
634457007216	Lipopolysaccharide-assembly; Region: LptE; pfam04390
634457007217	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
634457007218	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
634457007219	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634457007220	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634457007221	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634457007222	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
634457007223	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
634457007224	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
634457007225	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
634457007226	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
634457007227	Ligand binding site [chemical binding]; other site
634457007228	Electron transfer flavoprotein domain; Region: ETF; pfam01012
634457007229	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
634457007230	hydroxyglutarate oxidase; Provisional; Region: PRK11728
634457007231	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
634457007232	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
634457007233	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
634457007234	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457007235	FeS/SAM binding site; other site
634457007236	HemN C-terminal domain; Region: HemN_C; pfam06969
634457007237	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
634457007238	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
634457007239	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
634457007240	ligand binding site [chemical binding]; other site
634457007241	flexible hinge region; other site
634457007242	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
634457007243	putative switch regulator; other site
634457007244	non-specific DNA interactions [nucleotide binding]; other site
634457007245	DNA binding site [nucleotide binding]
634457007246	sequence specific DNA binding site [nucleotide binding]; other site
634457007247	putative cAMP binding site [chemical binding]; other site
634457007248	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
634457007249	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
634457007250	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634457007251	protein binding site [polypeptide binding]; other site
634457007252	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634457007253	protein binding site [polypeptide binding]; other site
634457007254	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
634457007255	nucleoside/Zn binding site; other site
634457007256	dimer interface [polypeptide binding]; other site
634457007257	catalytic motif [active]
634457007258	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
634457007259	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
634457007260	catalytic triad [active]
634457007261	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
634457007262	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634457007263	RNA binding surface [nucleotide binding]; other site
634457007264	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
634457007265	active site
634457007266	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
634457007267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457007268	S-adenosylmethionine binding site [chemical binding]; other site
634457007269	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
634457007270	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
634457007271	dimer interface [polypeptide binding]; other site
634457007272	ssDNA binding site [nucleotide binding]; other site
634457007273	tetramer (dimer of dimers) interface [polypeptide binding]; other site
634457007274	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
634457007275	O-Antigen ligase; Region: Wzy_C; pfam04932
634457007276	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
634457007277	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
634457007278	active site
634457007279	catalytic residues [active]
634457007280	DNA binding site [nucleotide binding]
634457007281	Int/Topo IB signature motif; other site
634457007282	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634457007283	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634457007284	catalytic residues [active]
634457007285	catalytic nucleophile [active]
634457007286	Presynaptic Site I dimer interface [polypeptide binding]; other site
634457007287	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634457007288	Synaptic Flat tetramer interface [polypeptide binding]; other site
634457007289	Synaptic Site I dimer interface [polypeptide binding]; other site
634457007290	DNA binding site [nucleotide binding]
634457007291	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634457007292	DNA-binding interface [nucleotide binding]; DNA binding site
634457007293	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007294	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634457007295	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634457007296	ATP binding site [chemical binding]; other site
634457007297	putative Mg++ binding site [ion binding]; other site
634457007298	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457007299	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457007300	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457007301	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457007302	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
634457007303	putative ADP-binding pocket [chemical binding]; other site
634457007304	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
634457007305	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
634457007306	active site
634457007307	HIGH motif; other site
634457007308	dimer interface [polypeptide binding]; other site
634457007309	KMSKS motif; other site
634457007310	protease TldD; Provisional; Region: tldD; PRK10735
634457007311	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634457007312	catalytic core [active]
634457007313	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
634457007314	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
634457007315	NAD binding site [chemical binding]; other site
634457007316	substrate binding site [chemical binding]; other site
634457007317	homodimer interface [polypeptide binding]; other site
634457007318	active site
634457007319	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
634457007320	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
634457007321	substrate binding site; other site
634457007322	tetramer interface; other site
634457007323	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
634457007324	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
634457007325	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
634457007326	NADP binding site [chemical binding]; other site
634457007327	active site
634457007328	putative substrate binding site [chemical binding]; other site
634457007329	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634457007330	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
634457007331	Probable Catalytic site; other site
634457007332	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
634457007333	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
634457007334	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
634457007335	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
634457007336	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
634457007337	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
634457007338	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457007339	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
634457007340	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
634457007341	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634457007342	putative C-terminal domain interface [polypeptide binding]; other site
634457007343	putative GSH binding site (G-site) [chemical binding]; other site
634457007344	putative dimer interface [polypeptide binding]; other site
634457007345	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
634457007346	putative N-terminal domain interface [polypeptide binding]; other site
634457007347	putative dimer interface [polypeptide binding]; other site
634457007348	putative substrate binding pocket (H-site) [chemical binding]; other site
634457007349	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
634457007350	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
634457007351	Ligand Binding Site [chemical binding]; other site
634457007352	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
634457007353	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634457007354	catalytic loop [active]
634457007355	iron binding site [ion binding]; other site
634457007356	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
634457007357	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
634457007358	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634457007359	catalytic residue [active]
634457007360	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
634457007361	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634457007362	catalytic residue [active]
634457007363	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
634457007364	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
634457007365	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
634457007366	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
634457007367	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
634457007368	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
634457007369	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
634457007370	active site
634457007371	HIGH motif; other site
634457007372	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
634457007373	KMSKS motif; other site
634457007374	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
634457007375	tRNA binding surface [nucleotide binding]; other site
634457007376	anticodon binding site; other site
634457007377	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
634457007378	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634457007379	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
634457007380	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
634457007381	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
634457007382	catalytic residues [active]
634457007383	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
634457007384	Family description; Region: UvrD_C_2; pfam13538
634457007385	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
634457007386	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
634457007387	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
634457007388	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
634457007389	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634457007390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457007391	active site
634457007392	phosphorylation site [posttranslational modification]
634457007393	intermolecular recognition site; other site
634457007394	dimerization interface [polypeptide binding]; other site
634457007395	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634457007396	DNA binding site [nucleotide binding]
634457007397	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
634457007398	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
634457007399	active site
634457007400	substrate binding site [chemical binding]; other site
634457007401	metal binding site [ion binding]; metal-binding site
634457007402	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
634457007403	dihydropteroate synthase; Region: DHPS; TIGR01496
634457007404	substrate binding pocket [chemical binding]; other site
634457007405	dimer interface [polypeptide binding]; other site
634457007406	inhibitor binding site; inhibition site
634457007407	FtsH Extracellular; Region: FtsH_ext; pfam06480
634457007408	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
634457007409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457007410	Walker A motif; other site
634457007411	ATP binding site [chemical binding]; other site
634457007412	Walker B motif; other site
634457007413	arginine finger; other site
634457007414	Peptidase family M41; Region: Peptidase_M41; pfam01434
634457007415	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
634457007416	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
634457007417	Ligand Binding Site [chemical binding]; other site
634457007418	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
634457007419	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634457007420	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634457007421	ligand binding site [chemical binding]; other site
634457007422	translocation protein TolB; Provisional; Region: tolB; PRK05137
634457007423	TolB amino-terminal domain; Region: TolB_N; pfam04052
634457007424	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
634457007425	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
634457007426	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634457007427	TolR protein; Region: tolR; TIGR02801
634457007428	TolQ protein; Region: tolQ; TIGR02796
634457007429	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
634457007430	active site
634457007431	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
634457007432	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457007433	Walker A motif; other site
634457007434	ATP binding site [chemical binding]; other site
634457007435	Walker B motif; other site
634457007436	arginine finger; other site
634457007437	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
634457007438	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
634457007439	RuvA N terminal domain; Region: RuvA_N; pfam01330
634457007440	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
634457007441	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
634457007442	active site
634457007443	putative DNA-binding cleft [nucleotide binding]; other site
634457007444	dimer interface [polypeptide binding]; other site
634457007445	hypothetical protein; Validated; Region: PRK00110
634457007446	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
634457007447	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
634457007448	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
634457007449	nucleotide binding region [chemical binding]; other site
634457007450	ATP-binding site [chemical binding]; other site
634457007451	SEC-C motif; Region: SEC-C; pfam02810
634457007452	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
634457007453	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
634457007454	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
634457007455	heterotetramer interface [polypeptide binding]; other site
634457007456	active site pocket [active]
634457007457	cleavage site
634457007458	RDD family; Region: RDD; pfam06271
634457007459	putative mechanosensitive channel protein; Provisional; Region: PRK11465
634457007460	Mechanosensitive ion channel; Region: MS_channel; pfam00924
634457007461	Biofilm formation and stress response factor; Region: BsmA; pfam10014
634457007462	chaperone protein DnaJ; Provisional; Region: PRK14299
634457007463	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634457007464	HSP70 interaction site [polypeptide binding]; other site
634457007465	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
634457007466	substrate binding site [polypeptide binding]; other site
634457007467	dimer interface [polypeptide binding]; other site
634457007468	Membrane fusogenic activity; Region: BMFP; pfam04380
634457007469	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
634457007470	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
634457007471	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
634457007472	H+ Antiporter protein; Region: 2A0121; TIGR00900
634457007473	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634457007474	IHF dimer interface [polypeptide binding]; other site
634457007475	IHF - DNA interface [nucleotide binding]; other site
634457007476	Rhamnan synthesis protein F; Region: RgpF; pfam05045
634457007477	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634457007478	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457007479	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457007480	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
634457007481	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634457007482	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
634457007483	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634457007484	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
634457007485	active site
634457007486	NAD synthetase; Reviewed; Region: nadE; PRK02628
634457007487	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
634457007488	multimer interface [polypeptide binding]; other site
634457007489	active site
634457007490	catalytic triad [active]
634457007491	protein interface 1 [polypeptide binding]; other site
634457007492	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
634457007493	homodimer interface [polypeptide binding]; other site
634457007494	NAD binding pocket [chemical binding]; other site
634457007495	ATP binding pocket [chemical binding]; other site
634457007496	Mg binding site [ion binding]; other site
634457007497	active-site loop [active]
634457007498	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
634457007499	putative active site pocket [active]
634457007500	4-fold oligomerization interface [polypeptide binding]; other site
634457007501	metal binding residues [ion binding]; metal-binding site
634457007502	3-fold/trimer interface [polypeptide binding]; other site
634457007503	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
634457007504	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
634457007505	putative active site [active]
634457007506	oxyanion strand; other site
634457007507	catalytic triad [active]
634457007508	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
634457007509	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634457007510	Coenzyme A binding pocket [chemical binding]; other site
634457007511	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
634457007512	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
634457007513	catalytic residues [active]
634457007514	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
634457007515	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
634457007516	substrate binding site [chemical binding]; other site
634457007517	glutamase interaction surface [polypeptide binding]; other site
634457007518	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
634457007519	metal binding site [ion binding]; metal-binding site
634457007520	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
634457007521	nucleotide binding site/active site [active]
634457007522	HIT family signature motif; other site
634457007523	catalytic residue [active]
634457007524	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
634457007525	putative FMN binding site [chemical binding]; other site
634457007526	hypothetical protein; Provisional; Region: PRK09126
634457007527	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
634457007528	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
634457007529	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
634457007530	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634457007531	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
634457007532	putative C-terminal domain interface [polypeptide binding]; other site
634457007533	putative GSH binding site (G-site) [chemical binding]; other site
634457007534	putative dimer interface [polypeptide binding]; other site
634457007535	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
634457007536	putative N-terminal domain interface [polypeptide binding]; other site
634457007537	putative dimer interface [polypeptide binding]; other site
634457007538	putative substrate binding pocket (H-site) [chemical binding]; other site
634457007539	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
634457007540	ParB-like nuclease domain; Region: ParB; smart00470
634457007541	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
634457007542	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634457007543	P-loop; other site
634457007544	Magnesium ion binding site [ion binding]; other site
634457007545	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634457007546	Magnesium ion binding site [ion binding]; other site
634457007547	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
634457007548	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
634457007549	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
634457007550	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
634457007551	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
634457007552	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
634457007553	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
634457007554	trmE is a tRNA modification GTPase; Region: trmE; cd04164
634457007555	G1 box; other site
634457007556	GTP/Mg2+ binding site [chemical binding]; other site
634457007557	Switch I region; other site
634457007558	G2 box; other site
634457007559	Switch II region; other site
634457007560	G3 box; other site
634457007561	G4 box; other site
634457007562	G5 box; other site
634457007563	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
634457007564	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
634457007565	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
634457007566	DNA binding site [nucleotide binding]
634457007567	active site
634457007568	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457007569	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457007570	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
634457007571	major facilitator superfamily transporter; Provisional; Region: PRK05122
634457007572	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457007573	putative substrate translocation pore; other site
634457007574	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
634457007575	dimer interface [polypeptide binding]; other site
634457007576	ADP-ribose binding site [chemical binding]; other site
634457007577	active site
634457007578	nudix motif; other site
634457007579	metal binding site [ion binding]; metal-binding site
634457007580	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
634457007581	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
634457007582	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634457007583	motif II; other site
634457007584	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
634457007585	substrate binding site [chemical binding]; other site
634457007586	active site
634457007587	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
634457007588	active site
634457007589	dimer interface [polypeptide binding]; other site
634457007590	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
634457007591	Phage Terminase; Region: Terminase_1; pfam03354
634457007592	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634457007593	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634457007594	catalytic residues [active]
634457007595	catalytic nucleophile [active]
634457007596	Presynaptic Site I dimer interface [polypeptide binding]; other site
634457007597	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634457007598	Synaptic Flat tetramer interface [polypeptide binding]; other site
634457007599	Synaptic Site I dimer interface [polypeptide binding]; other site
634457007600	DNA binding site [nucleotide binding]
634457007601	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634457007602	DNA-binding interface [nucleotide binding]; DNA binding site
634457007603	hypothetical protein; Provisional; Region: PRK14709
634457007604	D5 N terminal like; Region: D5_N; smart00885
634457007605	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
634457007606	polymerase nucleotide-binding site; other site
634457007607	DNA-binding residues [nucleotide binding]; DNA binding site
634457007608	nucleotide binding site [chemical binding]; other site
634457007609	primase nucleotide-binding site [nucleotide binding]; other site
634457007610	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
634457007611	Transposase; Region: HTH_Tnp_1; pfam01527
634457007612	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
634457007613	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634457007614	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634457007615	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634457007616	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634457007617	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634457007618	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634457007619	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634457007620	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634457007621	catalytic residues [active]
634457007622	catalytic nucleophile [active]
634457007623	Presynaptic Site I dimer interface [polypeptide binding]; other site
634457007624	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634457007625	Synaptic Flat tetramer interface [polypeptide binding]; other site
634457007626	Synaptic Site I dimer interface [polypeptide binding]; other site
634457007627	DDE superfamily endonuclease; Region: DDE_4; cl17710
634457007628	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634457007629	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
634457007630	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
634457007631	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
634457007632	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
634457007633	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634457007634	motif II; other site
634457007635	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
634457007636	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634457007637	Walker A/P-loop; other site
634457007638	ATP binding site [chemical binding]; other site
634457007639	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
634457007640	AAA domain; Region: AAA_12; pfam13087
634457007641	C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118
634457007642	PLD-like domain; Region: PLDc_2; pfam13091
634457007643	putative active site [active]
634457007644	catalytic site [active]
634457007645	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007646	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007647	Domain Homologous to E6-AP Carboxyl Terminus with; Region: HECTc; smart00119
634457007648	Transposase; Region: HTH_Tnp_1; pfam01527
634457007649	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634457007650	HTH-like domain; Region: HTH_21; pfam13276
634457007651	Integrase core domain; Region: rve; pfam00665
634457007652	Integrase core domain; Region: rve_3; pfam13683
634457007653	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
634457007654	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634457007655	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007656	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457007657	DNA binding site [nucleotide binding]
634457007658	Int/Topo IB signature motif; other site
634457007659	active site
634457007660	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
634457007661	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634457007662	non-specific DNA binding site [nucleotide binding]; other site
634457007663	salt bridge; other site
634457007664	sequence-specific DNA binding site [nucleotide binding]; other site
634457007665	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
634457007666	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634457007667	P-loop; other site
634457007668	Magnesium ion binding site [ion binding]; other site
634457007669	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634457007670	Magnesium ion binding site [ion binding]; other site
634457007671	ParB-like nuclease domain; Region: ParBc; pfam02195
634457007672	KorB domain; Region: KorB; pfam08535
634457007673	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
634457007674	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457007675	S-adenosylmethionine binding site [chemical binding]; other site
634457007676	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
634457007677	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
634457007678	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457007679	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634457007680	IHF dimer interface [polypeptide binding]; other site
634457007681	IHF - DNA interface [nucleotide binding]; other site
634457007682	TrwC relaxase; Region: TrwC; pfam08751
634457007683	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007684	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007685	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007686	Transposase domain (DUF772); Region: DUF772; pfam05598
634457007687	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634457007688	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634457007689	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
634457007690	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
634457007691	dimer interface [polypeptide binding]; other site
634457007692	active site
634457007693	metal binding site [ion binding]; metal-binding site
634457007694	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634457007695	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634457007696	NAD(P) binding site [chemical binding]; other site
634457007697	catalytic residues [active]
634457007698	Integrase core domain; Region: rve; pfam00665
634457007699	Winged helix-turn helix; Region: HTH_29; pfam13551
634457007700	Integrase core domain; Region: rve; pfam00665
634457007701	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457007702	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634457007703	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
634457007704	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
634457007705	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
634457007706	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
634457007707	Soluble P-type ATPase [General function prediction only]; Region: COG4087
634457007708	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
634457007709	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
634457007710	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
634457007711	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
634457007712	Ligand Binding Site [chemical binding]; other site
634457007713	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
634457007714	GAF domain; Region: GAF_3; pfam13492
634457007715	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634457007716	dimer interface [polypeptide binding]; other site
634457007717	phosphorylation site [posttranslational modification]
634457007718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457007719	ATP binding site [chemical binding]; other site
634457007720	Mg2+ binding site [ion binding]; other site
634457007721	G-X-G motif; other site
634457007722	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634457007723	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457007724	active site
634457007725	phosphorylation site [posttranslational modification]
634457007726	intermolecular recognition site; other site
634457007727	dimerization interface [polypeptide binding]; other site
634457007728	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634457007729	DNA binding site [nucleotide binding]
634457007730	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634457007731	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007732	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
634457007733	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634457007734	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
634457007735	Acyltransferase family; Region: Acyl_transf_3; pfam01757
634457007736	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
634457007737	Fic/DOC family; Region: Fic; cl00960
634457007738	Replication protein C N-terminal domain; Region: RP-C; pfam03428
634457007739	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
634457007740	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007741	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634457007742	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457007743	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
634457007744	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
634457007745	active site
634457007746	catalytic site [active]
634457007747	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
634457007748	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634457007749	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
634457007750	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634457007751	CrcB-like protein; Region: CRCB; cl09114
634457007752	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007753	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
634457007754	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457007755	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007756	Transposase domain (DUF772); Region: DUF772; pfam05598
634457007757	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
634457007758	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
634457007759	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
634457007760	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007761	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457007762	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457007763	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457007764	manganese transport protein MntH; Reviewed; Region: PRK00701
634457007765	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
634457007766	manganese transport regulator MntR; Provisional; Region: PRK11050
634457007767	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
634457007768	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
634457007769	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
634457007770	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
634457007771	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
634457007772	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634457007773	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
634457007774	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
634457007775	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
634457007776	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634457007777	iron-sulfur cluster [ion binding]; other site
634457007778	[2Fe-2S] cluster binding site [ion binding]; other site
634457007779	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457007780	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
634457007781	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457007782	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457007783	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457007784	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457007785	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457007786	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457007787	putative transposase OrfB; Reviewed; Region: PHA02517
634457007788	HTH-like domain; Region: HTH_21; pfam13276
634457007789	Integrase core domain; Region: rve; pfam00665
634457007790	Integrase core domain; Region: rve_3; pfam13683
634457007791	Transposase; Region: HTH_Tnp_1; cl17663
634457007792	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634457007793	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634457007794	Transposase domain (DUF772); Region: DUF772; pfam05598
634457007795	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457007796	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634457007797	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
634457007798	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634457007799	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
634457007800	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
634457007801	CRISPR-associated protein Cse2 (CRISPR_cse2); Region: CRISPR_Cse2; pfam09485
634457007802	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
634457007803	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
634457007804	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
634457007805	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
634457007806	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
634457007807	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
634457007808	Winged helix-turn helix; Region: HTH_29; pfam13551
634457007809	Integrase core domain; Region: rve; pfam00665
634457007810	Integrase core domain; Region: rve_3; pfam13683
634457007811	Predicted transcriptional regulator [Transcription]; Region: COG4190
634457007812	Abi-like protein; Region: Abi_2; pfam07751
634457007813	putative transposase OrfB; Reviewed; Region: PHA02517
634457007814	HTH-like domain; Region: HTH_21; pfam13276
634457007815	Integrase core domain; Region: rve; pfam00665
634457007816	Integrase core domain; Region: rve_3; pfam13683
634457007817	Transposase; Region: HTH_Tnp_1; cl17663
634457007818	Predicted membrane protein [Function unknown]; Region: COG3431
634457007819	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007820	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
634457007821	apolar tunnel; other site
634457007822	heme binding site [chemical binding]; other site
634457007823	dimerization interface [polypeptide binding]; other site
634457007824	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
634457007825	Transposase domain (DUF772); Region: DUF772; pfam05598
634457007826	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457007827	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634457007828	HTH-like domain; Region: HTH_21; pfam13276
634457007829	Integrase core domain; Region: rve; pfam00665
634457007830	Integrase core domain; Region: rve_3; pfam13683
634457007831	Transposase; Region: HTH_Tnp_1; pfam01527
634457007832	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
634457007833	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
634457007834	Abi-like protein; Region: Abi_2; cl01988
634457007835	myosin-cross-reactive antigen; Provisional; Region: PRK13977
634457007836	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457007837	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634457007838	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007839	Transposase domain (DUF772); Region: DUF772; pfam05598
634457007840	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
634457007841	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007842	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634457007843	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
634457007844	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
634457007845	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457007846	Transposase domain (DUF772); Region: DUF772; pfam05598
634457007847	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457007848	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634457007849	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634457007850	IHF dimer interface [polypeptide binding]; other site
634457007851	IHF - DNA interface [nucleotide binding]; other site
634457007852	putative transposase OrfB; Reviewed; Region: PHA02517
634457007853	HTH-like domain; Region: HTH_21; pfam13276
634457007854	Integrase core domain; Region: rve; pfam00665
634457007855	Integrase core domain; Region: rve_3; pfam13683
634457007856	Transposase; Region: HTH_Tnp_1; cl17663
634457007857	PemK-like protein; Region: PemK; cl00995
634457007858	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
634457007859	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634457007860	oligomeric interface; other site
634457007861	putative active site [active]
634457007862	homodimer interface [polypeptide binding]; other site
634457007863	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
634457007864	Integrase core domain; Region: rve_3; pfam13683
634457007865	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007866	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634457007867	DNA-binding interface [nucleotide binding]; DNA binding site
634457007868	hypothetical protein; Provisional; Region: PRK10621
634457007869	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
634457007870	DDE superfamily endonuclease; Region: DDE_5; pfam13546
634457007871	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007872	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457007873	active site
634457007874	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
634457007875	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
634457007876	acyl-activating enzyme (AAE) consensus motif; other site
634457007877	AMP binding site [chemical binding]; other site
634457007878	active site
634457007879	CoA binding site [chemical binding]; other site
634457007880	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
634457007881	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634457007882	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
634457007883	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
634457007884	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
634457007885	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
634457007886	dimerization interface [polypeptide binding]; other site
634457007887	putative ATP binding site [chemical binding]; other site
634457007888	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634457007889	Coenzyme A binding pocket [chemical binding]; other site
634457007890	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
634457007891	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634457007892	FeS/SAM binding site; other site
634457007893	Predicted amidohydrolase [General function prediction only]; Region: COG0388
634457007894	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
634457007895	putative active site [active]
634457007896	catalytic triad [active]
634457007897	putative dimer interface [polypeptide binding]; other site
634457007898	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
634457007899	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
634457007900	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634457007901	DNA-binding site [nucleotide binding]; DNA binding site
634457007902	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634457007903	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634457007904	homodimer interface [polypeptide binding]; other site
634457007905	catalytic residue [active]
634457007906	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634457007907	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457007908	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457007909	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
634457007910	dimerization interface [polypeptide binding]; other site
634457007911	substrate binding pocket [chemical binding]; other site
634457007912	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634457007913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457007914	putative substrate translocation pore; other site
634457007915	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457007916	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007917	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457007918	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
634457007919	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
634457007920	AAA domain; Region: AAA_30; pfam13604
634457007921	Family description; Region: UvrD_C_2; pfam13538
634457007922	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
634457007923	active site
634457007924	catalytic residues [active]
634457007925	DNA binding site [nucleotide binding]
634457007926	Int/Topo IB signature motif; other site
634457007927	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457007928	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457007929	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634457007930	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634457007931	catalytic residues [active]
634457007932	catalytic nucleophile [active]
634457007933	Presynaptic Site I dimer interface [polypeptide binding]; other site
634457007934	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634457007935	Synaptic Flat tetramer interface [polypeptide binding]; other site
634457007936	Synaptic Site I dimer interface [polypeptide binding]; other site
634457007937	DNA binding site [nucleotide binding]
634457007938	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634457007939	DNA-binding interface [nucleotide binding]; DNA binding site
634457007940	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1569
634457007941	Conjugal transfer protein TraD; Region: TraD; pfam06412
634457007942	putative transposase OrfB; Reviewed; Region: PHA02517
634457007943	HTH-like domain; Region: HTH_21; pfam13276
634457007944	Integrase core domain; Region: rve; pfam00665
634457007945	Integrase core domain; Region: rve_3; pfam13683
634457007946	Transposase; Region: HTH_Tnp_1; cl17663
634457007947	Hint domain; Region: Hint_2; pfam13403
634457007948	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457007949	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457007950	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634457007951	HTH-like domain; Region: HTH_21; pfam13276
634457007952	Integrase core domain; Region: rve; pfam00665
634457007953	Integrase core domain; Region: rve_3; pfam13683
634457007954	Transposase; Region: HTH_Tnp_1; pfam01527
634457007955	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634457007956	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634457007957	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634457007958	DNA-binding interface [nucleotide binding]; DNA binding site
634457007959	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634457007960	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634457007961	catalytic residues [active]
634457007962	catalytic nucleophile [active]
634457007963	Presynaptic Site I dimer interface [polypeptide binding]; other site
634457007964	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634457007965	Synaptic Flat tetramer interface [polypeptide binding]; other site
634457007966	Synaptic Site I dimer interface [polypeptide binding]; other site
634457007967	DNA binding site [nucleotide binding]
634457007968	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634457007969	DNA-binding interface [nucleotide binding]; DNA binding site
634457007970	Winged helix-turn helix; Region: HTH_29; pfam13551
634457007971	Helix-turn-helix domain; Region: HTH_28; pfam13518
634457007972	Homeodomain-like domain; Region: HTH_32; pfam13565
634457007973	Integrase core domain; Region: rve; pfam00665
634457007974	Integrase core domain; Region: rve_3; cl15866
634457007975	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
634457007976	Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842
634457007977	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634457007978	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634457007979	catalytic residues [active]
634457007980	catalytic nucleophile [active]
634457007981	Presynaptic Site I dimer interface [polypeptide binding]; other site
634457007982	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634457007983	Synaptic Flat tetramer interface [polypeptide binding]; other site
634457007984	Synaptic Site I dimer interface [polypeptide binding]; other site
634457007985	DNA binding site [nucleotide binding]
634457007986	ParA-like protein; Provisional; Region: PHA02518
634457007987	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634457007988	P-loop; other site
634457007989	Magnesium ion binding site [ion binding]; other site
634457007990	Replication initiator protein A; Region: RPA; pfam10134
634457007991	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
634457007992	putative addiction module antidote; Region: doc_partner; TIGR02609
634457007993	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
634457007994	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
634457007995	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
634457007996	putative active site [active]
634457007997	Protein of unknown function (DUF3680); Region: DUF3680; pfam12441
634457007998	Conjugal transfer protein TraD; Region: TraD; pfam06412
634457007999	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
634457008000	MobA/MobL family; Region: MobA_MobL; pfam03389
634457008001	AAA domain; Region: AAA_30; pfam13604
634457008002	Family description; Region: UvrD_C_2; pfam13538
634457008003	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
634457008004	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634457008005	oligomeric interface; other site
634457008006	putative active site [active]
634457008007	homodimer interface [polypeptide binding]; other site
634457008008	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
634457008009	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457008010	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634457008011	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634457008012	catalytic residues [active]
634457008013	catalytic nucleophile [active]
634457008014	AAA domain; Region: AAA_31; pfam13614
634457008015	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634457008016	P-loop; other site
634457008017	Magnesium ion binding site [ion binding]; other site
634457008018	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
634457008019	non-specific DNA binding site [nucleotide binding]; other site
634457008020	salt bridge; other site
634457008021	sequence-specific DNA binding site [nucleotide binding]; other site
634457008022	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634457008023	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634457008024	HTH-like domain; Region: HTH_21; pfam13276
634457008025	Integrase core domain; Region: rve; pfam00665
634457008026	Integrase core domain; Region: rve_3; pfam13683
634457008027	Transposase; Region: HTH_Tnp_1; pfam01527
634457008028	T5orf172 domain; Region: T5orf172; pfam10544
634457008029	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634457008030	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
634457008031	Pseudomurein-binding repeat; Region: PMBR; pfam09373
634457008032	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
634457008033	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634457008034	Fic family protein [Function unknown]; Region: COG3177
634457008035	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
634457008036	Fic/DOC family; Region: Fic; pfam02661
634457008037	PemK-like protein; Region: PemK; pfam02452
634457008038	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634457008039	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634457008040	Presynaptic Site I dimer interface [polypeptide binding]; other site
634457008041	catalytic residues [active]
634457008042	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634457008043	Synaptic Flat tetramer interface [polypeptide binding]; other site
634457008044	Synaptic Site I dimer interface [polypeptide binding]; other site
634457008045	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634457008046	DNA-binding interface [nucleotide binding]; DNA binding site
634457008047	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457008048	Hint domain; Region: Hint_2; pfam13403
634457008049	Transposase; Region: HTH_Tnp_1; pfam01527
634457008050	HTH-like domain; Region: HTH_21; pfam13276
634457008051	Integrase core domain; Region: rve; pfam00665
634457008052	Integrase core domain; Region: rve_3; pfam13683
634457008053	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
634457008054	non-specific DNA binding site [nucleotide binding]; other site
634457008055	salt bridge; other site
634457008056	sequence-specific DNA binding site [nucleotide binding]; other site
634457008057	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
634457008058	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634457008059	P-loop; other site
634457008060	Magnesium ion binding site [ion binding]; other site
634457008061	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457008062	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
634457008063	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634457008064	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634457008065	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457008066	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457008067	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457008068	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634457008069	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634457008070	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
634457008071	active site
634457008072	NTP binding site [chemical binding]; other site
634457008073	metal binding triad [ion binding]; metal-binding site
634457008074	antibiotic binding site [chemical binding]; other site
634457008075	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
634457008076	HsdM N-terminal domain; Region: HsdM_N; pfam12161
634457008077	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
634457008078	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634457008079	S-adenosylmethionine binding site [chemical binding]; other site
634457008080	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
634457008081	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
634457008082	FMN binding site [chemical binding]; other site
634457008083	active site
634457008084	substrate binding site [chemical binding]; other site
634457008085	catalytic residue [active]
634457008086	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457008087	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634457008088	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457008089	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457008090	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457008091	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
634457008092	putative substrate binding pocket [chemical binding]; other site
634457008093	dimerization interface [polypeptide binding]; other site
634457008094	acetylornithine deacetylase; Provisional; Region: PRK07522
634457008095	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
634457008096	metal binding site [ion binding]; metal-binding site
634457008097	putative dimer interface [polypeptide binding]; other site
634457008098	choline dehydrogenase; Validated; Region: PRK02106
634457008099	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634457008100	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
634457008101	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634457008102	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
634457008103	Na binding site [ion binding]; other site
634457008104	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
634457008105	homotrimer interaction site [polypeptide binding]; other site
634457008106	putative active site [active]
634457008107	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634457008108	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
634457008109	NAD(P) binding site [chemical binding]; other site
634457008110	catalytic residues [active]
634457008111	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
634457008112	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
634457008113	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
634457008114	Transposase; Region: HTH_Tnp_1; pfam01527
634457008115	HTH-like domain; Region: HTH_21; pfam13276
634457008116	Integrase core domain; Region: rve; pfam00665
634457008117	Integrase core domain; Region: rve_3; pfam13683
634457008118	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
634457008119	NMT1-like family; Region: NMT1_2; pfam13379
634457008120	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
634457008121	cheY-homologous receiver domain; Region: REC; smart00448
634457008122	ANTAR domain; Region: ANTAR; pfam03861
634457008123	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
634457008124	molybdopterin cofactor binding site; other site
634457008125	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
634457008126	molybdopterin cofactor binding site; other site
634457008127	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
634457008128	Flavodoxin; Region: Flavodoxin_1; pfam00258
634457008129	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
634457008130	FAD binding pocket [chemical binding]; other site
634457008131	conserved FAD binding motif [chemical binding]; other site
634457008132	phosphate binding motif [ion binding]; other site
634457008133	beta-alpha-beta structure motif; other site
634457008134	NAD binding pocket [chemical binding]; other site
634457008135	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457008136	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457008137	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457008138	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
634457008139	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
634457008140	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634457008141	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
634457008142	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
634457008143	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
634457008144	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
634457008145	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
634457008146	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
634457008147	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457008148	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
634457008149	sensor protein QseC; Provisional; Region: PRK10337
634457008150	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634457008151	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634457008152	dimer interface [polypeptide binding]; other site
634457008153	phosphorylation site [posttranslational modification]
634457008154	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634457008155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457008156	active site
634457008157	phosphorylation site [posttranslational modification]
634457008158	intermolecular recognition site; other site
634457008159	dimerization interface [polypeptide binding]; other site
634457008160	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634457008161	DNA binding site [nucleotide binding]
634457008162	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
634457008163	HlyD family secretion protein; Region: HlyD_2; pfam12700
634457008164	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634457008165	HlyD family secretion protein; Region: HlyD_3; pfam13437
634457008166	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634457008167	Outer membrane efflux protein; Region: OEP; pfam02321
634457008168	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634457008169	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457008170	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
634457008171	methionine synthase; Provisional; Region: PRK01207
634457008172	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
634457008173	substrate binding site [chemical binding]; other site
634457008174	THF binding site; other site
634457008175	zinc-binding site [ion binding]; other site
634457008176	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457008177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457008178	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
634457008179	putative dimerization interface [polypeptide binding]; other site
634457008180	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457008181	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457008182	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457008183	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634457008184	non-specific DNA binding site [nucleotide binding]; other site
634457008185	salt bridge; other site
634457008186	sequence-specific DNA binding site [nucleotide binding]; other site
634457008187	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
634457008188	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
634457008189	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
634457008190	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
634457008191	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
634457008192	arsenical pump membrane protein; Provisional; Region: PRK15445
634457008193	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
634457008194	transmembrane helices; other site
634457008195	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
634457008196	ArsC family; Region: ArsC; pfam03960
634457008197	catalytic residues [active]
634457008198	Protein of unknown function DUF45; Region: DUF45; pfam01863
634457008199	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
634457008200	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634457008201	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634457008202	ATP binding site [chemical binding]; other site
634457008203	putative Mg++ binding site [ion binding]; other site
634457008204	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634457008205	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634457008206	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634457008207	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
634457008208	HsdM N-terminal domain; Region: HsdM_N; pfam12161
634457008209	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634457008210	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
634457008211	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634457008212	HTH-like domain; Region: HTH_21; pfam13276
634457008213	Integrase core domain; Region: rve; pfam00665
634457008214	Integrase core domain; Region: rve_3; pfam13683
634457008215	Transposase; Region: HTH_Tnp_1; pfam01527
634457008216	CCC1-related family of proteins; Region: CCC1_like; cl00278
634457008217	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
634457008218	ArsC family; Region: ArsC; pfam03960
634457008219	catalytic residues [active]
634457008220	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
634457008221	Transposase; Region: HTH_Tnp_1; cl17663
634457008222	putative transposase OrfB; Reviewed; Region: PHA02517
634457008223	HTH-like domain; Region: HTH_21; pfam13276
634457008224	Integrase core domain; Region: rve; pfam00665
634457008225	Integrase core domain; Region: rve_3; pfam13683
634457008226	Integrase core domain; Region: rve; pfam00665
634457008227	Integrase core domain; Region: rve_3; pfam13683
634457008228	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634457008229	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634457008230	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
634457008231	putative substrate binding pocket [chemical binding]; other site
634457008232	putative dimerization interface [polypeptide binding]; other site
634457008233	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634457008234	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634457008235	Transposase; Region: HTH_Tnp_1; cl17663
634457008236	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634457008237	HTH-like domain; Region: HTH_21; pfam13276
634457008238	Integrase core domain; Region: rve; pfam00665
634457008239	Integrase core domain; Region: rve_3; pfam13683
634457008240	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634457008241	oligomeric interface; other site
634457008242	putative active site [active]
634457008243	homodimer interface [polypeptide binding]; other site
634457008244	Integrase core domain; Region: rve; pfam00665
634457008245	Winged helix-turn helix; Region: HTH_29; pfam13551
634457008246	Integrase core domain; Region: rve; pfam00665
634457008247	Transposase; Region: HTH_Tnp_1; pfam01527
634457008248	HTH-like domain; Region: HTH_21; pfam13276
634457008249	Integrase core domain; Region: rve; pfam00665
634457008250	Integrase core domain; Region: rve_3; pfam13683
634457008251	K+ potassium transporter; Region: K_trans; pfam02705
634457008252	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634457008253	HTH-like domain; Region: HTH_21; pfam13276
634457008254	Integrase core domain; Region: rve; pfam00665
634457008255	Integrase core domain; Region: rve_3; pfam13683
634457008256	Transposase; Region: HTH_Tnp_1; pfam01527
634457008257	K+ potassium transporter; Region: K_trans; cl15781
634457008258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457008259	Walker A motif; other site
634457008260	ATP binding site [chemical binding]; other site
634457008261	Walker B motif; other site
634457008262	arginine finger; other site
634457008263	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
634457008264	Integrase core domain; Region: rve; pfam00665
634457008265	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457008266	TrwC relaxase; Region: TrwC; pfam08751
634457008267	Integrase core domain; Region: rve; pfam00665
634457008268	Integrase core domain; Region: rve_3; pfam13683
634457008269	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457008270	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
634457008271	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
634457008272	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634457008273	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634457008274	catalytic residue [active]
634457008275	Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524
634457008276	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634457008277	Walker A motif; other site
634457008278	ATP binding site [chemical binding]; other site
634457008279	Walker B motif; other site
634457008280	RelB antitoxin; Region: RelB; cl01171
634457008281	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
634457008282	AAA-like domain; Region: AAA_10; pfam12846
634457008283	Transposase; Region: HTH_Tnp_1; pfam01527
634457008284	HTH-like domain; Region: HTH_21; pfam13276
634457008285	Integrase core domain; Region: rve; pfam00665
634457008286	Integrase core domain; Region: rve_3; pfam13683
634457008287	Protein of unknown function (DUF2859); Region: DUF2859; cl12633
634457008288	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457008289	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634457008290	active site
634457008291	Transposase; Region: HTH_Tnp_1; cl17663
634457008292	HTH-like domain; Region: HTH_21; pfam13276
634457008293	Integrase core domain; Region: rve; pfam00665
634457008294	Integrase core domain; Region: rve_3; pfam13683
634457008295	Hint domain; Region: Hint_2; pfam13403
634457008296	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457008297	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457008298	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
634457008299	putative active site [active]
634457008300	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634457008301	HTH-like domain; Region: HTH_21; pfam13276
634457008302	Integrase core domain; Region: rve; pfam00665
634457008303	Integrase core domain; Region: rve_3; pfam13683
634457008304	Transposase; Region: HTH_Tnp_1; pfam01527
634457008305	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
634457008306	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
634457008307	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457008308	active site
634457008309	DNA binding site [nucleotide binding]
634457008310	Int/Topo IB signature motif; other site
634457008311	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
634457008312	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634457008313	Outer membrane efflux protein; Region: OEP; pfam02321
634457008314	Outer membrane efflux protein; Region: OEP; pfam02321
634457008315	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
634457008316	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
634457008317	DNA binding residues [nucleotide binding]
634457008318	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
634457008319	dimer interface [polypeptide binding]; other site
634457008320	putative metal binding site [ion binding]; other site
634457008321	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634457008322	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
634457008323	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
634457008324	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
634457008325	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
634457008326	Soluble P-type ATPase [General function prediction only]; Region: COG4087
634457008327	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
634457008328	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
634457008329	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
634457008330	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
634457008331	Ligand Binding Site [chemical binding]; other site
634457008332	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
634457008333	GAF domain; Region: GAF_3; pfam13492
634457008334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634457008335	dimer interface [polypeptide binding]; other site
634457008336	phosphorylation site [posttranslational modification]
634457008337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634457008338	ATP binding site [chemical binding]; other site
634457008339	Mg2+ binding site [ion binding]; other site
634457008340	G-X-G motif; other site
634457008341	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634457008342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634457008343	active site
634457008344	phosphorylation site [posttranslational modification]
634457008345	intermolecular recognition site; other site
634457008346	dimerization interface [polypeptide binding]; other site
634457008347	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634457008348	DNA binding site [nucleotide binding]
634457008349	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634457008350	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634457008351	short chain dehydrogenase; Provisional; Region: PRK06180
634457008352	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
634457008353	NADP binding site [chemical binding]; other site
634457008354	active site
634457008355	steroid binding site; other site
634457008356	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
634457008357	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
634457008358	potential catalytic triad [active]
634457008359	conserved cys residue [active]
634457008360	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
634457008361	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634457008362	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634457008363	ATP binding site [chemical binding]; other site
634457008364	putative Mg++ binding site [ion binding]; other site
634457008365	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634457008366	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
634457008367	HsdM N-terminal domain; Region: HsdM_N; pfam12161
634457008368	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634457008369	Helix-turn-helix domain; Region: HTH_17; pfam12728
634457008370	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457008371	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634457008372	active site
634457008373	DNA binding site [nucleotide binding]
634457008374	Int/Topo IB signature motif; other site
634457008375	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
634457008376	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634457008377	oligomeric interface; other site
634457008378	putative active site [active]
634457008379	homodimer interface [polypeptide binding]; other site
634457008380	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
634457008381	Integrase core domain; Region: rve; pfam00665
634457008382	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634457008383	Walker A motif; other site
634457008384	ATP binding site [chemical binding]; other site
634457008385	Walker B motif; other site
634457008386	arginine finger; other site
634457008387	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
634457008388	CcdB protein; Region: CcdB; cl03380
634457008389	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457008390	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634457008391	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457008392	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634457008393	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
634457008394	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634457008395	Transposase; Region: HTH_Tnp_1; cl17663
634457008396	Helix-turn-helix domain; Region: HTH_28; pfam13518
634457008397	Winged helix-turn helix; Region: HTH_29; pfam13551
634457008398	Homeodomain-like domain; Region: HTH_32; pfam13565
634457008399	Integrase core domain; Region: rve; pfam00665
634457008400	Integrase core domain; Region: rve_3; pfam13683
634457008401	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
634457008402	ParB-like nuclease domain; Region: ParBc; pfam02195
634457008403	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
634457008404	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634457008405	S-adenosylmethionine binding site [chemical binding]; other site
634457008406	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
634457008407	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634457008408	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
634457008409	helicase superfamily c-terminal domain; Region: HELICc; smart00490
634457008410	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634457008411	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634457008412	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634457008413	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
634457008414	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634457008415	active site
634457008416	DNA binding site [nucleotide binding]
634457008417	Int/Topo IB signature motif; other site
634457008418	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634457008419	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
634457008420	DDE superfamily endonuclease; Region: DDE_5; cl17874
634457008421	putative transposase OrfB; Reviewed; Region: PHA02517
634457008422	HTH-like domain; Region: HTH_21; pfam13276
634457008423	Integrase core domain; Region: rve; pfam00665
634457008424	Integrase core domain; Region: rve_3; pfam13683