-- dump date   	20250216_232645
-- class       	Genbank::CDS
-- table       	cds_function
-- id	function
ACL_RS00010	this protein binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of replication (oriC)
ACL_RS00030	this is a DNA binding protein that assists the filamentation of RecA onto DNA for the initiation of recombination or recombinational repair
ACL_RS00035	DNA gyrase is ATP-dependent enzyme that primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II consists of two polypeptide subunits, gyrA and gyrB, which form a heterotetramer: (BA)2
ACL_RS00040	DNA gyrase is ATP-dependent enzyme that primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II consists of two polypeptide subunits, gyrA and gyrB, which form a heterotetramer: (BA)2
ACL_RS00065	nucleotide-binding protein
ACL_RS00070	this protein is a member of pdu operon that function is to degrade 1,2-propanediol by a pathway that requires coenzyme B12, adenosylcobalamin (AdoCbl). Exact function of the PduL protein is not yet determined
ACL_RS00080	putative ribonuclease M5
ACL_RS00085	this enzyme catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine to two adjacent adenosine bases in 16S rRNA
ACL_RS00100	this protein cleaves peptidyl-tRNA or N-acyl-aminoacyl-tRNA to yield free peptides or N-acyl-amino acids and tRNA
ACL_RS00105	this protein is a DNA-dependent ATPase, DNA repair enzyme
ACL_RS00130	glycerophospholipid metabolism
ACL_RS00145	this enzyme catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA
ACL_RS00150	this enzyme is a radical-SAM domain protein that oxidizes a single glycine residue in the Pfl protein to the corresponding radical by transfer of a proton from its CH2 to AdoMet with concomitant cleavage of the latter
ACL_RS00165	this protein one of the enzymes participating in the transfer of one-carbon units, an essential element of various biosynthetic pathways. In many of these processes the transfers of one-carbon units are mediated by the coenzyme tetrahydrofolate
ACL_RS00195	putative sugar transport system
ACL_RS00200	putative sugar transport system
ACL_RS00225	this enzyme is responsible for the hydrolysis of pyrophosphate which is formed principally as the product of the many biosynthetic reactions that utilize ATP
ACL_RS00240	this protein catalyses the transfer of a hydroxymethyl group from N5, N10- methylene tetrahydrofolate to glycine, resulting in the formation of serine and tetrahydrofolate. Enzyme is pyridoxal phosphate dependent
ACL_RS00245	putative electron transport complex
ACL_RS00250	putative electron transport complex
ACL_RS00265	putative electron transport complex
ACL_RS00270	probable RnafA subunit of the NADH oxidoreductase complex RnfABCDGE type
ACL_RS00275	this enzyme may be involved in the conversion of aminoimidazole ribotide to 4-amino-5-hydroxymethyl-2-methyl pyrimidine during the biosynthesis of the pyrimidine moiety of thiamine
ACL_RS00295	this protein is an ubiquitous enzyme that catalyzes the ATP-dependent phosphorylation of thymidine
ACL_RS00310	transketolase catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways.
ACL_RS00315	function of this highly conserved protein is not yet known
ACL_RS00320	this protein is a predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division
ACL_RS00530	this protein is a component of the preprotein translocase pathway, that allows secretion across the membrane
ACL_RS00535	this enzyme is a phosphotransferase that catalyses the reversible reaction: AMP + MgATP = ADP + MgADP. This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates
ACL_RS00540	this protein catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides
ACL_RS07100	deoxyribonuclease I
ACL_RS00585	DNA damage repair protein
ACL_RS00590	this enzyme hydrolyses peptides of 7 and 17 amino acids with fairly broad specificity
ACL_RS00600	this protein reduces oxidised thioredoxin in the presence of NADPH. Reduced thioredoxin serves as an electron donor for thioredoxin peroxidase which consequently reduces H2O2 to H2O.
ACL_RS00605	thioredoxins are small disulphide-containing redox proteins that serve as a general protein disulphide oxidoreductase.
ACL_RS00615	probable cobalt transport system
ACL_RS07105	probable cobalt transport system
ACL_RS00625	this protein catalyzes the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)
ACL_RS00630	this enzyme catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP): ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. Thymidylate kinase is important in the dTTP synthesis pathway for DNA synthesis
ACL_RS00640	putative RNA methyltransferase
ACL_RS00645	putative S-adenosyl-dependent methyl transferase
ACL_RS00750	this protein is a transcriptional elongation factor involved in transcription termination and anti-termination, interacting with the termination factor Rho and RNA polymerase
ACL_RS07125	this endonuclease is sequence independent, dsDNA-specific. Biological role is unknown.
ACL_RS07130	endonuclease I (EC:3.1.21.-) is extracellular, sequence- independent, dsDNA-specific endonuclease. Its biological role is unknown.
ACL_RS00785	endonuclease I (EC:3.1.21.-) is extracellular, sequence- independent, dsDNA-specific endonuclease. Its biological role is unknown.
ACL_RS00835	rRNA (guanine-N2-)-methyltransferase
ACL_RS00855	C-terminal part of this protein contains GGDEF domain that synthesizes cyclic di-GMP, which is used as an intracellular signalling molecule.
ACL_RS00960	predicted signaling protein part contains GGDEF and DHH domains
ACL_RS00970	Dps (DNA protection during starvation) proteins exhibit nonspecific DNA-binding activity that is at least partially linked with iron complexation. DNA bound by these proteins was shown to suffice for protection against oxidative DNA damage and might be mediated by magnesium ions, which bridge the protein surfaces with the polyanionic DNA. Stress-inducible proteins.
ACL_RS00980	such proteins reduce chromate accumulation and are essential for chromate resistance.
ACL_RS00985	RF-1 helps to recognise and terminate translation at UAA and UAG stop codons.
ACL_RS00990	similar to the methylase of polypeptide chain release factors
ACL_RS01000	ribosome binding protein, which GTPase activity is stimulated by the large ribosomal subunit
ACL_RS01010	this protein catalyzes conversion of uracil to uridine 5'-monophosphate utilizing 5'-phosphoribosyl--1-pyrophosphate. UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.
ACL_RS07140	poly(A) polymerase family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase (EC:2.7.7.19), which adds the poly (A) tail to mRNA. This family also includes the tRNA nucleotidyltransferase (EC:2.7.7.25) that adds the CCA to the 3' of the tRNA.
ACL_RS01040	beta-lactamase catalyses the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins
ACL_RS01045	similar to predicted methyltransferase
ACL_RS01050	Mscl proteins forms a channel organized as a homopentamer. Such channels play a critical role in transducing physical stresses at the cell membrane (e.g. stretch force in the membrane) into a electrochemical response. May participate in the regulation of osmotic pressure changes
ACL_RS01060	DAHP (3-deoxy-D-arabino-heptulosonate-7-phosphate) synthase catalyzes the first step in aromatic amino acid biosynthesis from chorismate. DAHP synthase is a metal -activated enzyme, which is the target for negative-feedback regulation by pathway intermediates or by end products.
ACL_RS01065	this protein catalyses oxidative decarboxylation of prephenate to 4-hydroxyphenylpyruvate
ACL_RS01070	this protein catalyses the formation of dehydroquinate (DHQ) and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate (DAHP). This reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids
ACL_RS01080	this protein catalyses the rearrangement of chorismate to prephenate, the reaction at the branch point of the biosynthetic pathway leading to the three aromatic amino acids, phenylalanine, tryptophan and tyrosine (chorismic acid is the last common intermediate, and CM leads to the L-phenylalanine/L-tyrosine branch)
ACL_RS01085	this protein catalyses the fourth step of the shikimate pathway, which is the NADP-dependent reduction of 3-dehydroshikimate to shikimate
ACL_RS01090	this protein catalyzes the last of the seven steps in the shikimate pathway. It catalyzes the 1,4-trans elimination of the phosphate group from 5-enolpyruvylshikimate-3-phosphate (EPSP) to form chorismate which can then be used in phenylalanine, tyrosine or tryptophan biosynthesis
ACL_RS01100	this protein catalyzes the synthesis of coenzyme A and mevalonate in isoprenoid synthesis
ACL_RS01105	this protein catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to produce HMG-CoA and CoA
ACL_RS01110	this protein participates in recombination and DNA repair. It helps to process Holliday junction intermediates to mature products by catalysing branch migration. RecG has DNA unwinding activity characteristic of a DNA helicase with 3' to 5' polarity
ACL_RS01120	the main function of this protein is in the processing of pre-rRNAs, the maturation and degradation of mRNAs, and the maturaton of tRNAs
ACL_RS01130	endonuclease III is a DNA repair enzyme which removes a number of damaged pyrimidines from DNA via its glycosylase activity and also cleaves the phosphodiester backbone at apurinic / apyrimidinic sites via a beta-elimination mechanism. The structurally related DNA glycosylase MutY recognises and excises the mutational intermediate 8-oxoguanine-adenine mispair
ACL_RS01185	this is the central protein in the diverse metabolic pathways, mainly in the fatty acid synthesis system and the polyketide synthesis
ACL_RS01205	radical SAM proteins catalyze diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S-adenosylmethionine (SAM) through an unusual Fe-S center
ACL_RS01225	phenylalanyl-tRNA synthetase is an alpha2/beta2 tetramer
ACL_RS01230	phenylalanyl-tRNA synthetase is an alpha2/beta2 tetramer
ACL_RS01235	radical SAM proteins catalyze diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S-adenosylmethionine (SAM) through an unusual Fe-S center
ACL_RS01245	this enzyme converts D-ribulose 5-phosphate into D-xylulose 5-phosphate in Calvin's reductive pentose phosphate cycle
ACL_RS01250	this protein catalyses the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the enzyme cofactor thiamine pyrophosphate (TPP, coenzyme B1)
ACL_RS01260	this protein (also known as dihydroxyacetone kinase) catalyses the phosphorylation of glycerone in the presence of ATP to glycerone phosphate in the glycerol utilization pathway
ACL_RS01290	probable regulator of genes involved in phosphosugar metabolism
ACL_RS01300	O-glycosyl hydrolases hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety
ACL_RS01315	beta-lactamase catalyses the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins
ACL_RS07155	Ig-like domains are usually found in cell surface proteins. N-acetylmuramoyl-L-alanine amidase cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala)
ACL_RS07160	putative sugar transport system
ACL_RS01340	putative sugar transport system
ACL_RS01365	putative sugar transport system
ACL_RS01370	putative sugar transport system
ACL_RS01385	O-glycosyl hydrolases hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety
ACL_RS01390	this protein catalyses reaction: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate. This is the first enzyme in the metabolism of N-acetylglucosamine
ACL_RS01395	this protein catalyses reaction: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate
ACL_RS01405	this protein catalyses the conversion of D-glucosamine 6-phosphate and water to D-fructose 6-phosphate in the N-acetylglucosamine utilization pathway
ACL_RS01415	this protein catalyses the second step in glycosylphosphatidylinositol (GPI) biosynthesis
ACL_RS01490	EF-G (or EF2) is responsible for the translocation of the peptidyl-tRNA from the A-site to the P-site (peptidyl-tRNA site) of the ribosome, thereby freeing the A-site for the next aminoacyl-tRNA to bind. GTPase
ACL_RS01510	superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Their function is to destroy the radicals that are normally produced within cells and are toxic to biological systems
ACL_RS01515	fibronectin is a part of extracellular matrix and has critical roles in eukaryotic cellular processes, such as adhesion, migration and differentiation, it is also a substrate for the attachment of bacteria (e.g. fibronectin binding is considered to be an important virulence factor in streptococcal infections).
ACL_RS01520	this protein catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP.
ACL_RS01525	the omega subunit is required to promote RNAP assembly by acting like a chaperone to maintain beta' in the correct conformation and to recruit it to the alpha(2)beta subassembly to form a functional core enzyme
ACL_RS01530	DNA damage excision repair system includes uvrA, uvrB, and uvrC gene products
ACL_RS01555	this enzyme is responsible for the anomeric interconversion of D-glucose and other aldoses between their alpha- and beta-forms.
ACL_RS07170	this protein removes the ammonia group from a glutamate molecule and transfers it to a specific substrate, thus creating a new carbon-nitrogen group on the substrate.
ACL_RS01585	nusA (N utilisation substance protein A) binds to RNA polymerase alpha subunit and promotes termination at certain RNA hairpin structures.
ACL_RS01600	IF-2 promotes the GTP-dependent binding of the initiator tRNA to the small subunit of the ribosome
ACL_RS01605	RbfA associates with free 30S ribosomal subunits, but not with 30S subunits that are part of 70S ribosomes or polysomes. It is essential for efficient processing of 16S rRNA
ACL_RS01620	this protein, also known as replication factor Y (superfamily II helicase), is a component of the primosome which is involved in replication, repair, and recombination
ACL_RS01625	this protein transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP.
ACL_RS01640	this protein catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is an important methyl donor for transmethylation and is also the propylamino donor in polyamine biosynthesis.
ACL_RS01645	exact function of LemA protein is unknown. Small N-terminal part of the protein is extracellular, while the most part of protein is cytosolic.
ACL_RS01655	there is a conserved real translational frameshift at a TGA codon. RF-2 helps to terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient
ACL_RS01690	proteins of this family are involved in the degradation of the ribonucleotide moiety on RNA-DNA hybrid molecules carrying out endonucleolytic cleavage to 5'-phospo-monoester. This family also includes Ribonuclease HIII.
ACL_RS01695	type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap
ACL_RS01730	this protein plays protective antioxidant role in cells through its peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified. None cofactors are needed in contrast to other peroxidases.
ACL_RS01735	the signal recognition particle (SRP) mediates the protein transport to or across the membrane. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognated receptor (SR)
ACL_RS01740	homologs of this protein are often part of operons that encode components of the SRP pathway, and this protein may regulate the expression of an operon related to the SRP pathway
ACL_RS01745	the signal recognition particle (SRP) mediates the protein transport to or across the membrane. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognated receptor (SR).
ACL_RS01750	this protein also contains 3#-5# and 5#-3# exonuclease domains both. The former is responsible for the 3'-5' exonuclease proofreading activity, catalyzing the hydrolysis of unpaired or mismatched nucleotides. The 5'-3' exonuclease domain is involved in structure-specific cleavage of flaps formed by Pol I activity
ACL_RS07185	N-terminal part of this protein is the formamidopyrimidine-DNA glycosylase (EC: 3.2.2.23), a DNA repair enzyme that excises oxidised purines from damaged DNA. The shorter C-terminal part of this protein is the dephospho-CoA kinase (EC: 2.7.1.24) that catalyzes the final step in CoA biosynthesis (the phosphorylation of dephosphocoenzyme A (dCoA) to CoA)
ACL_RS01760	this protein is essential for both replication initiation and membrane attachment of the origin region of the chromosome
ACL_RS01780	this protein is similar to the Na+ efflux pump
ACL_RS01800	this protein plays a role in repair of DNA damage after UV and X-ray irradiation
ACL_RS01825	this protein associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation
ACL_RS01845	RuvA, RuvB, and RuvC proteins process the universal DNA intermediate of homologous recombination, termed Holliday junction
ACL_RS01850	RuvA, RuvB, and RuvC proteins process the universal DNA intermediate of homologous recombination, termed Holliday junction
ACL_RS01860	this hydrophobic integral membrane protein provides resistance to the antibiotic bacitracin
ACL_RS01865	the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) is a major carbohydrate transport system in bacteria. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. Sugar-specific permease consists of at least three structurally distinct domains (IIA, IIB, and IIC)
ACL_RS01870	the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) is a major carbohydrate transport system in bacteria. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. Sugar-specific permease consists of at least three structurally distinct domains (IIA, IIB, and IIC).
ACL_RS01880	putative tRNA (guanine-N(7)-)-methyltransferase
ACL_RS01890	NADPH-dependent oxidoreductase
ACL_RS01895	topoisomerase IV primarily decatenates DNA and relaxes positive supercoils
ACL_RS01900	topoisomerase IV primarily decatenates DNA and relaxes positive supercoils
ACL_RS01945	putative sugar ABC transporter
ACL_RS01950	putative sugar ABC transporter
ACL_RS01955	these enzymes catalyze the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA
ACL_RS01975	this protein is a part of the glycine decarboxylase multienzyme complex. The reaction catalysed by P-protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
ACL_RS01980	this protein is a part of the glycine decarboxylase multienzyme complex. The reaction catalysed by P-protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
ACL_RS01985	this protein is a part of the glycine decarboxylase multienzyme complex. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
ACL_RS01990	this protein is a part of the glycine decarboxylase multienzyme complex
ACL_RS02010	this enzyme (2-phospho-D-glycerate hydrolase) catalyses the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways
ACL_RS02015	this enzyme catalyzes the conversion of dihydroxyacetone phosphate to methylglyoxal and phosphate: Glycerone phosphate = methylglyoxal + phosphate. It provides bacteria with an alternative to triosephosphate isomerase for metabolizing dihydroxyacetone phosphate
ACL_RS02030	SsrA RNA recognizes ribosomes stalled on defective messages and acts as a tRNA and mRNA to mediate the degradation of the partially synthesized nascent polypeptide chain. SmpB protein is an essential component of the SsrA quality-control system. SmpB binds specifically and with high affinity to SsrA RNA and is required for stable association of SsrA with ribosomes in vivo
ACL_RS02060	this protein contains one endonuclease domain and two helicase domains
ACL_RS02070	this protein is similar to fructokinases, which catalyze the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate
ACL_RS02105	NADP-dependent alcohol dehydrogenases with a wide variety of substrate specificities
ACL_RS02110	chaperones protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates
ACL_RS02115	this protein is similar to glycolate oxidase, GlcD (EC 1.1.3.15), that preferentially oxidizes short-chain aliphatic hydroxy acids
ACL_RS02155	The PTS (phosphoenolpyruvate-dependent sugar phosphotransferase) system is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars. One subunit of the PTS system is membrane-bound complex EII with sugar-specific permease activity. EII consists of at least three structurally distinct domains IIA, IIB and IIC. IIA domain carries the first permease-specific phosphorylation site, a histidine which is phosphorylated by phospho-HPr.
ACL_RS02185	PTS (phosphoenolpyruvate-dependent sugar phosphotransferase) system is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars. EI- enzyme I.
ACL_RS02195	The Fic (Filamentation induced by cAMP) protein was described in E. coli. The Fic protein is involved in the synthesis of p-aminobenzoate or folate. The Fic protein and cAMP were supposed to be involved in a new regulatory mechanism of cell division via folate metabolism
ACL_RS02240	C-terminal part of this protein contains GGDEF domain that synthesizes cyclic di-GMP, which used as an intracellular signalling molecule
ACL_RS02250	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Majority of VWA-containing proteins are extracellular. A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands.
ACL_RS02265	ATPases of P-type transport a variety of different compounds, including ions and phospholipids, across a membrane using ATP hydrolysis for energy
ACL_RS02285	this protein is a subunit of the acetyl-CoA carboxylase complex, that catalyzes the first step in the synthesis of long-chain fatty acids, which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association.
ACL_RS02290	this protein is a subunit of the acetyl-CoA carboxylase complex, that catalyzes the first step in the synthesis of long-chain fatty acids, which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association
ACL_RS02295	this protein is a subunit of the acetyl-CoA carboxylase complex, that catalyzes the first step in the synthesis of long-chain fatty acids, which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association
ACL_RS02300	this protein is a subunit of the acetyl-CoA carboxylase complex, that catalyzes the first step in the synthesis of long-chain fatty acids, which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association
ACL_RS02305	this protein initiates elongation in fatty acid biosynthesis. It is responsible for producing the multitude of fatty acid structures found in bacterial membranes
ACL_RS02310	this protein is involved in fatty acid biosynthesis and transfers the malonyl moeity from coenzyme A to acyl-carrier protein.
ACL_RS02315	fatty acid biosynthesis ptotein
ACL_RS02320	this enzyme catalyzes the condensation of malonyl-ACP with the growing fatty acid chain. This protein is a component of a number of enzymatic systems, e.g. fatty acid synthetase (FAS), which catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH
ACL_RS02325	FabZ is the primary dehydratase involved in fatty-acid elongation in the fatty acid biosynthesis of type II. It catalyses the dehydration of beta-hydroxyacyl acyl carrier protein (ACP) to trans 2-enoyl ACP
ACL_RS07200	this protein (also known as holocarboxylase synthetase) catalyses the covalent attachment of the biotin prosthetic group to a specific lysine of the biotin carboxyl carrier domain of biotin-dependent carboxylases in a two-step reaction
ACL_RS02335	thioredoxin reductase reduces oxidised thioredoxin in the presence of NADPH. Reduced thioredoxin serves as an electron donor for thioredoxin peroxidase which consequently reduces H2O2 to H2O.
ACL_RS02355	putative spermidine/putrescine transport system
ACL_RS02360	putative spermidine/putrescine transport system
ACL_RS02365	putative spermidine/putrescine transport system
ACL_RS02370	putative spermidine/putrescine transport system
ACL_RS02375	NusB protein is involved in the regulation of rRNA biosynthesis by transcriptional antitermination
ACL_RS02380	exonuclease VII catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield 5'-phosphomononucleotides
ACL_RS02385	exonuclease VII catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield 5'-phosphomononucleotides
ACL_RS02395	RecN is a DNA damage inducible protein involved in recombinational processes
ACL_RS02410	ATP-dependent RNA unwinding is needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation
ACL_RS02440	this enzyme synthesizes the major nonbilayer-prone membrane lipid alpha-monoglucosyldiacylglycerol in A.laidlawii. This protein is related to a large group of lipid glycosyltransferases and has homologs in related pathogenic bacteria. This enzyme is probably attached to the membrane by charge-charge and hydrophobic interactions
ACL_RS02455	such enzymes are involved in the maintenance of the appropriate protein tyrosine phosphorylation level that is essential for many cellular functions (e.g. signal transduction, cell cycle control, proliferation). Tyrosine-specific phosphatases catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. Low molecular weight protein-tyrosine phosphatases (or acid phosphatase) act on tyrosine phosphorylated proteins, low molecular weight aryl phosphates and natural and synthetic acyl phosphates
ACL_RS02465	this is the first enzyme in the NAD salvage synthesis from nicontinate (niacin). PncB catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid
ACL_RS02470	MATE (Multi Antimicrobial Extrusion) family proteins function as drug/sodium antiporters. These proteins mediate resistance to a wide range of cationic dyes, fluroquinolones, aminoglycosides and other structurally diverse antibodies and drugs
ACL_RS02475	this protein is involved in tRNA and rRNA base modification
ACL_RS02485	this enzyme is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate
ACL_RS02490	branched-chain amino acid transport system
ACL_RS02495	branched-chain amino acid transport system
ACL_RS02505	branched-chain amino acid transport system
ACL_RS02510	branched-chain amino acid transport system
ACL_RS02520	this protein performes thiolysis of acetoacetyl-CoA and is involved in biosynthetic pathways such as poly beta-hydroxybutyrate synthesis or steroid biogenesis
ACL_RS02525	3-ketoacyl-acyl carrier protein reductase (FabG) is involved in type II fatty acid biosynthesis
ACL_RS02530	beta-ketoacyl-acyl carrier protein synthase III (FabH), in general, initiates elongation in type II fatty acid synthase system and is responsible for producing the multitude of fatty acid structures found in bacterial membranes
ACL_RS02550	this protein is related to the tRNA (uracil-5-)-methyltransferase
ACL_RS02565	DEAD box RNA helicase
ACL_RS02570	this protein is related to the tRNA (uracil-5-)-methyltransferase
ACL_RS02600	this enzyme uses ADP-glucose as the glucose donor
ACL_RS02605	GlgC is involved in the glycogen synthesis pathway. GlgC is also called ADP-glucose pyrophosphorylase
ACL_RS07205	Ig-like folded domains are usually found in bacterial surface proteins such as intimins. Intimin is a bacterial cell-adhesion molecule that mediates the intimate bacterial host-cell interaction
ACL_RS02675	members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars
ACL_RS02685	the trigger factor is involved in protein export. Trigger factor is a ribosome-associated molecular chaperone and is the first chaperone interacting with nascent polypeptide and maintaining its open conformation
ACL_RS02690	the Lon serine proteases hydrolyse ATP to degrade protein substrates. In E. coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock
ACL_RS02720	this is an ATP-dependent enzyme responsible for the addition of a polyglutamate tail to folate and folate derivatives. Plays a key role in the retention of the intracellular folate pool
ACL_RS02725	this protein catalyses the release of fatty acids from lysophsopholipids
ACL_RS02755	molecular chaperones protect proteins in the intracellular milieu from irreversible aggregation during synthesis and in times of cellular stress. DnaK is a component of he DnaK-DnaJ-GrpE chaperone system. GrpE is nucleotide exchange factor, stimulating the rate of ADP release 5000-fold.
ACL_RS02760	molecular chaperones protect proteins in the intracellular milieu from irreversible aggregation during synthesis and in times of cellular stress. DnaK is a component of he DnaK-DnaJ-GrpE chaperone system.
ACL_RS02765	molecular chaperones protect proteins in the intracellular milieu from irreversible aggregation during synthesis and in times of cellular stress. DnaK is a component of he DnaK-DnaJ-GrpE chaperone system.
ACL_RS02770	lipoic acid is the covalently attached cofactor of several multi-component enzyme complexes that catalyze key metabolic reactions. LplA catalyzes the attachment of lipoic acids to the target proteins
ACL_RS02775	predicted metal-binding, possibly nucleic acid-binding protein
ACL_RS02785	this protein is involved in cell envelope biogenesis
ACL_RS02790	N-terminal part of this protein is plsC (1-acyl-sn-glycerol-3-phosphate acyltransferase, EC 2.3.1.51) involved in lipid metabolism, while C-terminal part is occupied with Fur (ferric uptake regulator)
ACL_RS02795	this protein is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). This enzyme synthesizes the immediate precursor of NAD
ACL_RS02800	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis. This protein contains NAD-synthase domain and an additional N-terminal amidohydrolase domain that prefer glutamine. Such two-domain structure of NAD-synthase is typical to eukaryotes and some prokaryotes
ACL_RS02805	this protein is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs. Catalyses reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate
ACL_RS02810	RecD is part of a RecBCD complex
ACL_RS02815	this protein is similar to phospholipase/carboxylesterase family
ACL_RS02850	this protein is highly similar to diadenosine hexa- (Ap6A) or tetraphosphate (Ap4A) hydrolases of NUDIX superfamily. NUDIX hydrolases (NUcleoside DIphosphate linked to some other moiety X) require a divalent cation, such as Mg2+ or Mn2+ for their activity
ACL_RS02855	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase (trmA)
ACL_RS02875	this protein catalyses the formation of cyclic AMP/GMP(cAMP/cGMP) from ATP/GTP
ACL_RS02900	serine recombinases perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases
ACL_RS02940	DNA restriction-modification mechanisms protect the organism against invading foreign DNA. Sequence-specific
ACL_RS02945	DNA restriction-modification mechanisms protect the organism against invading foreign DNA. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system
ACL_RS02950	DNA restriction-modification mechanisms protect the organism against invading foreign DNA. Sequence-specific
ACL_RS07485	E. coli plasmid protein ParB preferentially cleaves ssDNA. ParB also nicks supercoiled plasmid DNA preferably at sites with potential single-stranded character, like AT-rich regions and sequences that can form cruciform structures. ParB also exhibits 5--3 exonuclease activity
ACL_RS02990	this enzyme synthesizes S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is an important methyl donor for transmethylation and is also the propylamino donor in polyamine biosynthesis
ACL_RS03030	Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. Terminase large subunit possesses an endonuclease and ATPase activity
ACL_RS03040	the portal proteins form a channel through which the viral DNA is packaged into the capsid, and exits during infection
ACL_RS03055	this protein is similar to putative phage capsid proteins from Bacillus spp
ACL_RS03135	lysis protein that contains two predicted largely hydrophobic helices at the N-terminus
ACL_RS07520	McrBC system mediates sequence-specific restriction of cytosine-modified DNA. McrB has GTPase activity and high affinity to methylated DNA
ACL_RS03180	this protein participates in post-transcriptional control of mRNA stability and translational efficiency. It is also involved in the processing and maturation of ribosomal RNA precursors, and processing of phage and plasmid transcripts.
ACL_RS03200	this protein catalyses the Na(+)-dependent uptake of extracellular glutamate
ACL_RS03210	putative antimicrobial peptide transport system
ACL_RS03220	lipid metabolism
ACL_RS03225	this enzyme synthesizes pseudouridine from uracil in ribosomal RNA
ACL_RS03240	arginine transport system
ACL_RS03245	arginine transport system
ACL_RS03250	arginine transport system
ACL_RS03255	putative transporter
ACL_RS03260	short-chain alcohol dehydrogenase of unknown specificity
ACL_RS03265	oxidation of critical methionine residues leads to inactivation of many proteins. Methionine sulfoxide reductase B reduces B-stereoisomers of methionine sulfoxides during oxidative stress response
ACL_RS03270	this protein transfers a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan
ACL_RS03275	alpha-amylase is an essential enzyme in alpha-glucan metabolism, acting to catalyse the hydrolysis of alpha-1,4-glucosidic bonds of glycogen, starch and related polysaccharides
ACL_RS03280	alpha-amylase is an essential enzyme in alpha-glucan metabolism, acting to catalyse the hydrolysis of alpha-1,4-glucosidic bonds of glycogen, starch and related polysaccharides
ACL_RS03285	alpha-amylase is an essential enzyme in alpha-glucan metabolism, acting to catalyse the hydrolysis of alpha-1,4-glucosidic bonds of glycogen, starch and related polysaccharides
ACL_RS07240	sugar transport system
ACL_RS07245	sugar transport system
ACL_RS03300	sugar transport system
ACL_RS03330	alpha-amylase is an essential enzyme in alpha-glucan metabolism, acting to catalyse the hydrolysis of alpha-1,4-glucosidic bonds of glycogen, starch and related polysaccharides
ACL_RS03335	sugar transport system
ACL_RS03340	this protein protects cell against damage from endogenously-formed hydroxyperoxides, catalyses the reduction of hydroxyperoxides by glutathione: 2 Glutathione + H2O(2) = oxidised Glutathione + 2H2O
ACL_RS03345	N-terminal transmembrane anchor of this protein is followed by the CBS domain that binds ligands with an adenosyl group such as AMP, ATP and S-AdoMet. C-terminal domain is CorC_HlyC region, that is associated with various transporters
ACL_RS07250	Multi-domain protein. N-terminal domain forms the transmembrane anchor. The second domain is diguanylate-cyclase (DGC) or GGDEF domain, followed by the conserved C-terminal regulatory enzyme domain with catalytic activity of the metal dependent phosphohydrolase
ACL_RS03375	this protein replaces HemF function under anaerobic conditions. HemN catalyses the anaerobic transformation of coproporhyrinogen-III into protoporphyrinogen-IX during porphyrin biosynthesis
ACL_RS03380	DNA breaking-rejoining enzyme. Contains tyrosine active site. Interacts with XerC
ACL_RS03385	this protein is involved in the purine and pyrimidine salvage pathway of nucleotide synthesis. It catalyses a phosphotransfer on ribose and deoxyribose, converting D-ribose 1-phosphate to D-ribose 5-phosphate, and 2-deoxy-D-ribose 1-phosphate to 2-deoxy-D-ribose 5-phosphate
ACL_RS03415	monovalent cation/H+ antiporter
ACL_RS07255	phospholipid/glycerol acyltransferase
ACL_RS03435	this enzyme reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-methylenetetrahydrofolate which is then utilized by thymidylate synthase
ACL_RS03440	this enzyme catalyzes the reductive methylation of dUMP to dTMP with concomitant conversion of 5,10-methylenetetrahydrofolate to dihydrofolate: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. This provides the sole de novo pathway for production of dTMP and is the only enzyme in folate metabolism in which the 5,10-methylenetetrahydrofolate is oxidised during one-carbon transfer. The enzyme is essential for regulating the balanced supply of the 4 DNA precursors in normal DNA replication
ACL_RS03445	metal-dependent aminoacylase, which catalyse the final step in arginine biosynthesis
ACL_RS03455	this protein binds with high affinity to ssDNA and protect ssDNA intermediates during DNA metabolic pathways
ACL_RS03475	this enzyme is involved in the salvage of nucleotides and nucleosides
ACL_RS03480	this enzyme catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2-deoxyribose 5-phosphate. Deoxyribose-phophate aldolase appears to function in the catabolism of deoxyribonucleotides
ACL_RS03510	YchF may function as a GTP-dependent translational factor. YchF possess the TGS domain related to the RNA-binding proteins
ACL_RS03535	nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor
ACL_RS03570	this protein is also known as glucan endo-1,3-beta-D-glucosidase. Hydrolyzes 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans such as laminarins, curdlans, paramylons, and pachymans, with very limited action on mixed-link (1,3-1,4-)-beta-D-glucans
ACL_RS03575	sugar transport system
ACL_RS03580	sugar transport system
ACL_RS03585	sugar transport system
ACL_RS03595	sugar transport system
ACL_RS03600	sugar transport system
ACL_RS03605	sugar transport system
ACL_RS03620	this protein is also known as glucan endo-1,3-beta-D-glucosidase. Hydrolyzes 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans such as laminarins, curdlans, paramylons, and pachymans, with very limited action on mixed-link (1,3-1,4-)-beta-D-glucans
ACL_RS03640	DsbA is a bacterial protein-folding factor for disulfide bonded secreted proteins.FrnE is a DsbA-like protein containing a CXXC motif. FrnE is presumed to be a dithiol-disulfide isomerase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins
ACL_RS03650	this enzyme cleaves medium sized peptides
ACL_RS03675	this protein increases tolerance to divalent metal ions such as cadmium, zinc, and cobalt. Protein forms efflux pump that remove these ions from cells
ACL_RS03690	ZIP family protein (divalent heavy-metal cations transporters)
ACL_RS03695	transcriptional repressor, may serve as global regulator
ACL_RS03710	this enzyme accelerates protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACL_RS03740	rhodanese is a sulphurtransferase involved in cyanide detoxification
ACL_RS03750	rhodanese is a sulphurtransferase involved in cyanide detoxification
ACL_RS03780	probable GNAT family member
ACL_RS03790	this enzyme catalyzes the NADPH-dependent reduction of ammonia and L-2-amino-6-ketopimelate to form meso-diaminopimelate, the direct precursor of L-lysine
ACL_RS03800	this protein is related to diketogluconate reductase.
ACL_RS03815	members of this family are drug/sodium antiporters that mediate resistance to a wide range of cationic dyes, fluroquinolones, aminoglycosides and other structurally diverse antibodies and drugs
ACL_RS03840	putative multidrug resistance transport system
ACL_RS03845	putative multidrug resistance transport system
ACL_RS03850	putative multidrug resistance transport system
ACL_RS03860	tryptophan synthase catalyzes the last step in the biosynthesis of tryptophan: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O
ACL_RS03870	this protein is involved in a specialized system that confers resistance to Hg(II) on catalysing the reaction: Hg(II) + NADPH=Hg(0) + NADP + H
ACL_RS03900	DapB is involved in the biosynthesis of diaminopimelic acid, a component of bacterial cell walls, and the essential amino acid L-lysine. It catalyses generation of the tetrahydrodipicolinate: 2,3-dihydrodipicolinate + NAD(P)H = 2,3,4,5-tetrahydrodipicolinate + NAD(P)(+)
ACL_RS03905	this protein is the key enzyme in lysine biosynthesis via the diaminopimelate pathway. Catalyses the condensation of L-aspartate-beta-semialdehyde and pyruvate to dihydropicolinic acid
ACL_RS03910	this enzyme converts aspartyl phosphate to aspartate-semialdehyde
ACL_RS03915	this enzyme catalyzes the phosphorylation of aspartate. The latter can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine
ACL_RS03920	this enzyme catalyzes the final step in the lysine biosynthetic pathway converting meso-diaminopimelic acid (DAP) to L-lysine
ACL_RS03935	this enzyme catalyzes the irreversible and NADPH-dependent reductive deamination of GMP into IMP (inosine 5'-monophosphate). It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides
ACL_RS03940	ACP thioesterases terminate fatty acyl group extension via hydrolyzing an acyl group on a fatty acid
ACL_RS03955	this enzyme catalyses the interconversion of isopentenyl diphosphate and dimethylallyl diphosphate. Dimethylallyl phosphate is the initial substrate for the biosynthesis of carotenoids and other long chain isoprenoids
ACL_RS03960	this enzyme catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway
ACL_RS03965	this enzyme catalyzes the decarboxylation of mevalonate pyrophosphate to isopentyl pyrophosphate (IPP), the last step in the synthesis of IPP in the mevalonate pathway.Catalyzed reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2
ACL_RS03975	this enzyme accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues
ACL_RS03980	uncharacterized enzyme, probably involved in pigment biosynthesis
ACL_RS04000	this enzyme can process single-stranded RNA, but is stalled by double-stranded structures such as stem-loops. Was found in degradosomes
ACL_RS04015	riboflavin is converted into catalytically active cofactors (FAD and FMN) by the actions of riboflavin kinase (EC:2.7.1.26), which converts it into FMN, and FAD synthetase (EC:2.7.7.2), which adenylates FMN to FAD
ACL_RS04020	this protein catalyzes the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Usually it makes psi55 in the T loop of tRNAs
ACL_RS04025	thioredoxin alters the redox state of proteins and in such a way regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors
ACL_RS04030	mismatch repair ATPase
ACL_RS04035	this protein cleaves RNA from DNA-RNA hybrids. It catalyses endonucleolytic cleavage to 5'-phospho-monoesters
ACL_RS04040	this enzyme is responsible for synthesis of pseudouridine from uracil in 23S rRNA
ACL_RS04060	this enzyme hydrolyzes dCMP into dUMP
ACL_RS04065	this enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine
ACL_RS04110	this is ATP-independent intracellular protease that may hydrolyze small peptides to provide a nutritional source
ACL_RS04120	this protein is required for DNA recombination and repair
ACL_RS04150	this enzyme is responsible for the synthesis of UDP-glucose, a key compound in the biosynthesis of polysaccharides
ACL_RS04175	putative multidrug resistance transport system
ACL_RS04180	putative multidrug resistance transport system
ACL_RS04200	phosphoglucomutase (EC:5.4.2.2) is responsible for the conversion of D-glucose 1-phosphate to D-glucose 6-phosphate. The enzyme participates in both the breakdown and synthesis of glucose. Phosphomannomutase (EC:5.4.2.8) is involved in the conversion of D-mannose 1-phosphate to D-mannose 6-phosphate
ACL_RS04205	putative regulatory protein
ACL_RS07270	glutamine amidotransferase activity involves the removal of the ammonia group from a glutamate molecule and its subsequent transfer to a specific substrate, thus creating a new carbon-nitrogen group on the substrate
ACL_RS04285	choline kinase catalyses the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway
ACL_RS04310	the exact function of these proteins is not yet clear but they are capable of wrapping DNA and stabilizing it from denaturation under extreme environmental conditions
ACL_RS04315	this enzyme catalyzes the conversion of glycerol-3-phosphate into dihydroxyacetone phosphate
ACL_RS04330	this enzyme catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors
ACL_RS04335	this enzyme is responsible for synthesis of pseudouridine from uracil in ribosomal RNA
ACL_RS04345	this enzyme catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway (biosynthesis of aromatic amino acids from chorismate) and the catabolic quinate pathway
ACL_RS04350	this enzyme catalyzes the fifth step in the biosynthesis of aromatic amino acids from chorismate (the so-called shikimate pathway). The enzyme catalyzes the following reaction: ATP + shikimate = ADP + shikimate-3-phosphate
ACL_RS04355	this enzyme modifies tRNAs at A(37) to give isopentenyl A(37)
ACL_RS04360	this protein together with the MutS protein is a key component of the DNA repair machinery that corrects replication errors. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signalling complex for repair
ACL_RS04365	this protein together with the MutL protein is a key component of the DNA repair machinery that corrects replication errors. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signalling complex for repair
ACL_RS04390	putative multidrug resistance transport system
ACL_RS04395	putative multidrug resistance transport system
ACL_RS04400	multifunctional enzyme that plays a role in homologous recombination, DNA repair and induction of the SOS response. In homologous recombination, the protein functions as a DNA-dependent ATPase, promoting synapsis, heteroduplex formation and strand exchange between homologous DNAs
ACL_RS04405	this enzyme catalyses the conversion ofCDP-diacylglycerol and glycerol-3-phosphate to CMP and 3-(3-phosphatidyl)-glycerol 1-phosphate in the biosynthesis of acidic phospholipids
ACL_RS04430	extracellular surface-anchored protein; DNA binding and uptake
ACL_RS04455	GreA promotes transcription elongation by stimulating an endogenous, endonucleolytic transcript cleavage activity of the RNA polymerase (RNAP). This protein induces cleavage of 3'-RNA fragments 2A#3 nt in length and can only prevent the formation of arrested complexes
ACL_RS04495	GGDEF domain function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule
ACL_RS04500	this protein exchanges Na+ for H+ in an electroneutral manner, and this activity is carried out by a family of Na+/H+ exchangers. This antiporter eject protons from cells, effectively eliminating excess acid from actively metabolising cells
ACL_RS04505	this protein reduces chromate accumulation and is essential for chromate resistance
ACL_RS04655	putative lipid A export transport system
ACL_RS07295	DNA primase synthesizes the RNA primers for the Okazaki fragments in lagging strand DNA synthesis
ACL_RS04685	this protein is required for the damage avoidance-tolerance pathway(s). The RecO protein may contain a mononucleotide-binding fold
ACL_RS04695	this is a small homotetrameric zinc metalloprotein, that may act on deoxycytidine as well as cytidine
ACL_RS04705	ATPase, predicted
ACL_RS04725	putative enterochelin transport system
ACL_RS04730	putative enterochelin transport system
ACL_RS04740	putative enterochelin transport system
ACL_RS04760	this enzyme catalyses the first step in the pentose pathway, i.e. the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH
ACL_RS04765	this is an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways (PPP)
ACL_RS04770	putative divalent metal ion transporter
ACL_RS04775	putative divalent metal ion transporter
ACL_RS04780	NADH:quinone oxidoreductase respiratory complex
ACL_RS07300	FMN-binding domain protein of the NADH:quinone oxidoreductase respiratory complex
ACL_RS04790	NADH:quinone oxidoreductase respiratory complex
ACL_RS04795	NADH:quinone oxidoreductase respiratory complex
ACL_RS04800	NADH:quinone oxidoreductase respiratory complex
ACL_RS04805	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The D subunit appears to be located in the central stalk of V1 complex
ACL_RS04810	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The B subunits along with the A subunits form the catalytic core of the V1 complex
ACL_RS04850	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. Subunit epsilon may be important for for connecting the rotor of F1 (gamma subunit) to the rotor of F0 (C subunit)
ACL_RS04855	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. Beta subunits along with the alpha subunits form the catalytic core of the F1 complex
ACL_RS04860	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. Gamma subunit forms the central shaft that connects the F0 rotary motor to the F1 catalytic core
ACL_RS04865	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. Alpha subunits along with the beta subunits form the catalytic core of the F1 complex
ACL_RS04870	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. This subunit appears to be part of the peripheral stalk that holds the F1 complex alpha3beta3 catalytic core stationary against the torque of the rotating central stalk, and links subunit A of the F0 complex with the F1 complex
ACL_RS04875	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. This subunit appears to be part of the peripheral stalk that holds the F1 complex alpha3beta3 catalytic core stationary against the torque of the rotating central stalk, and links subunit A of the F0 complex with the F1 complex
ACL_RS04880	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. Ten C subunits form an oligomeric ring that makes up the F0 rotor
ACL_RS04885	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. The subunit A is a key component of the proton channel, and may play a direct role in the translocation of protons across the membrane
ACL_RS04910	probable multidrug transport system
ACL_RS04915	probable multidrug transport system
ACL_RS04935	this protein is a tripeptide aminopeptidase with a substrate preference for hydrophobic peptides
ACL_RS04965	mechanosensitive channels provide protection against hypo-osmotic shock, responding both to stretching of the cell membrane and to membrane depolarisation
ACL_RS04980	putative extracellular peptidase S26B
ACL_RS04995	putative extracellular peptidase S26B
ACL_RS05015	this protein contains GGDEF and EAL domains, both involved in the signal transduction. In particular, GGDEF domain function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule, while EAL domain is a candidate for a diguanylate phosphodiesterase function in diverse bacterial signaling proteins
ACL_RS05020	this protein contains EAL domain, which is a candidate for a diguanylate phosphodiesterase function in diverse bacterial signaling protein.
ACL_RS05045	putative lipopolysaccharide biosynthesis protein
ACL_RS05050	this enzyme hydrolyses peptides of 7 and 17 amino acids with fairly broad specificity
ACL_RS05060	this protein is a DNA helicase that functions in the nucleotide excision repair and is a endonuclease that makes the 3' incision next to DNA damage
ACL_RS05070	NAD-binding protein
ACL_RS05085	this protein is NAD-dependent enzyme that catalyzes the final step in anaerobic glycolysis in which pyruvate is converted to L-lactate
ACL_RS05125	this enzyme catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc
ACL_RS05130	this enzyme converts glucosamine-6-phosphate to glucosamine-1-phosphate as part of the pathway toward UDP-N-acetylglucosamine for peptidoglycan and lipopolysaccharides
ACL_RS05140	this enzyme catalyses the production of UDP-ManNAc from UDP-GlcNAc
ACL_RS05160	this enzyme catalyses the production of UDP-ManNAc from UDP-GlcNAc
ACL_RS05185	putative carbamoylphosphate synthase large subunit
ACL_RS05205	this protein interconverts UDP-glucose and UDP-galactose which are precursors of glucose- and galactose-containing exopolysaccharides
ACL_RS05255	this enzyme is responsible for the conversion of D-glucose 1-phosphate to D-glucose 6-phosphate. The enzyme participates in both the breakdown and synthesis of glucose
ACL_RS05265	ROK (Repressor, ORF, Kinase) family groups transcriptional repressors, sugar kinases and yet uncharacterized ORFs. This family includes N-acetylglucosamine repressor, nagC, from E. coli; glucokinase EC:2.7.1.2 from Streptomyces coelicolor; fructokinase EC:2.7.1.4 from Streptococcus mutans. The repressor proteins contains N-terminal HTH DNA-binding domain
ACL_RS05275	probable sugar transport system
ACL_RS05285	probable sugar transport system
ACL_RS05290	ATP-dependent DNA helicase, uvrD-type
ACL_RS05305	this protein is a member of a distinct group of short helix-turn-helix proteins. This group includes the characterized member HigA, without which the killer protein HigB cannot be cloned. The hig (host inhibition of growth) system is noted to be unusual in that killer protein is encoded by the upstream member of the gene pair
ACL_RS05350	this protein recognises the double-stranded unmethylated sequence GATC and cleaves before G-1
ACL_RS05355	this is probable N-4 cytosine-specific or N-6 adenine-specific DNA methylase
ACL_RS05365	serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme
ACL_RS05370	this protein catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides
ACL_RS05395	this enzyme catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6- bisphosphate, a key regulatory step in the glycolytic pathway
ACL_RS05400	this enzyme catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6- bisphosphate, a key regulatory step in the glycolytic pathway
ACL_RS05405	glutamate dehydrogenases are a broadly distributed group of enzymes that catalyse the reversible oxidative deamination of glutamate to ketoglutarate and ammonia
ACL_RS05415	this protein catalyzes the NAD-dependent reversible reductive amination of pyruvate into alanine
ACL_RS05425	metal ion uptake regulatory protein
ACL_RS05430	metal ions transport system
ACL_RS05435	metal ions transport system
ACL_RS05440	metal ion binding lipoprotein
ACL_RS05445	this protein function is the repair of DNA containing O6-alkylated guanine by transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. Protein is also able to repair O-4-methylthymine
ACL_RS05460	LrgA and LrgB proteins are both thought to control murein hydrolase activity and penicillin tolerance
ACL_RS05465	LrgA protein has been hypothesised to export murein hydrolases
ACL_RS05470	bifunctional protein: diaminohydroxyphosphoribosylaminopyrimidine deaminase / aminodioxyphosphoribosylaminopyrimidine reductase
ACL_RS05475	electron transfer flavoproteins serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. Electron transfer flavoproteins are heterodimeric proteins composed of an alpha and beta subunit, and contain an FAD cofactor and AMP
ACL_RS05480	electron transfer flavoproteins serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. Electron transfer flavoproteins are heterodimeric proteins composed of an alpha and beta subunit, and contain an FAD cofactor and AMP
ACL_RS05510	peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process
ACL_RS05560	this protein participates in cell protection from stress by controlling the aggregation and denaturation of vital cellular structures
ACL_RS05565	this family consists of the N-terminal region of exopolyphosphatase (Ppx) [EC:3.6.1.11] and guanosine pentaphosphate phospho-hydrolase (GppA) [EC:3.6.1.40]
ACL_RS05595	probable heavy metal ion transporting ATPase
ACL_RS05600	probable metal ion transporting ATPase
ACL_RS05625	glutamine amidotransferase activity involves the removal of the ammonia group from a glutamate molecule and its subsequent transfer to a specific substrate, thus creating a new carbon-nitrogen group on the substrate. PfpI, is a putative intracellular cysteine protease. DJ-1 was previously described in eukaryotes as oncogene
ACL_RS07315	this enzyme is involved in the recycling of the components of S-adenosylmethionine after it has donated one of its two non-ribose sulphur ligands to an acceptor. In the case when 5'-methylthioadenosine is used as the substrate the corresponding reaction is the first step of the methionine salvage pathway in bacteria
ACL_RS05635	uridine kinase catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP
ACL_RS05685	putative phosphatidate cytidylyltransferase [EC:2.7.7.41], that catalyzes the synthesis of CDP-diacylglycerol from CTP and phosphatidate (PA): CDP-diacylglycerol is an important branch point intermediate.
ACL_RS05690	this enzyme generates undecaprenyl pyrophosphate from isopentenyl pyrophosphate
ACL_RS05695	this enzyme catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction
ACL_RS05710	this protein dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. RRF is believed to bind the ribosome at the A-site in a manner that mimics tRNA, but the specific mechanisms remain unclear
ACL_RS05715	this protein converts UMP to UDP by adding a phosphate from ATP. It is the first step in pyrimidine biosynthesis
ACL_RS05730	dUTPase hydrolyzes dUTP to dUMP and pyrophosphate, simultaneously reducing dUTP levels and providing the dUMP for dTTP biosynthesis. dUTPase decreases the intracellular concentration of dUPT so that uracil cannot be incorporated into DNA
ACL_RS05740	XerD-like integrases are DNA breaking-rejoining enzymes involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid inheritance
ACL_RS05745	the function of gid proteins is unknown. They are closely related to gidA (glucose-inhibited division protein A)
ACL_RS05770	probable peptidase, S24 family
ACL_RS05775	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The D subunit appears to be located in the central stalk of V1 complex
ACL_RS05780	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The B subunits along with the A subunits form the catalytic core of the V1 complex
ACL_RS05795	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The F subunit is part of V1 complex and is required for the assembly and activity of V-ATPase
ACL_RS05805	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The I subunit is found in the V0 complex and is a transmembrane glycoprotein required for the assembly and proton transport activity of the ATPase complex
ACL_RS05820	this enzyme plays an important role in glycolysis and gluconeogenesis by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-diphospho-glycerate
ACL_RS05840	this protein catalyzes the reduction of arsenate to arsenite, and thus extends resistance to include arsenate that is basically provided by ArsA and ArsB genes
ACL_RS05845	this enzyme hydrolyses peptides of 7 and 17 amino acids with fairly broad specificity
ACL_RS05855	this protein contains GGDEF and EAL domains that both participate in signal transduction. GGDEF domain function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule. EAL domain is found in diverse bacterial signalling proteins and is a good candidate for a diguanylate phosphodiesterase function
ACL_RS05880	tRNA (guanine-N1-)-methyltransferase is one of several nucleases operating together with the tRNA-modifying enzymes before the formation of the mature tRNA. It catalyses the reaction: methylating guanosine(G) to N1-methylguanine (1-methylguanosine (m1G)) at position 37 of tRNAs that read CUN (leucine), CCN(proline), and CGG (arginine) codons
ACL_RS05885	this protein is essential for efficient processing of 16S rRNA
ACL_RS05930	this protein is required for thiazole synthesis in the thiamine biosynthesis pathway
ACL_RS05935	putative GAF sensor protein
ACL_RS05945	N-acetylglucosaminylphosphatidylinositol deacetylase (EC:3.5.1.89) catalyzes the second step in glycosylphosphatidylinositol-anchor biosynthesis
ACL_RS05960	this protein reduces oxidised thioredoxin in the presence of NADPH. Reduced thioredoxin serves as an electron donor for thioredoxin peroxidase which consequently reduces H2O2 to H2O
ACL_RS05975	the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) is a major carbohydrate transport system in bacteria. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. Sugar-specific permease consists of at least three structurally distinct domains (IIA, IIB, and IIC).
ACL_RS05985	this protein is an enzyme that catalyses the formation of ATP to ADP and vice versa. In the second step of the second phase in glycolysis, 1,3-diphosphoglycerate is converted to 3-phosphoglycerate, forming one molecule of ATP
ACL_RS06005	sulphur assimilation protein complex
ACL_RS06010	sulphur assimilation protein complex
ACL_RS06015	sulphur assimilation protein complex
ACL_RS06020	sulphur assimilation protein complex
ACL_RS06025	sulphur assimilation protein complex, ABC transport system ATPase component
ACL_RS06035	putative oligopeptide transport system
ACL_RS06040	putative oligopeptide transport system
ACL_RS07330	putative oligopeptide transport system
ACL_RS06050	putative oligopeptide transport system
ACL_RS06055	putative oligopeptide transport system
ACL_RS06080	this enzyme catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia
ACL_RS06110	uncharacterized transport system
ACL_RS06115	uncharacterized transport system
ACL_RS06120	uncharacterized transport system
ACL_RS06125	mutidrug resistance transport system
ACL_RS06130	mutidrug resistance transport system
ACL_RS06175	this protein is required for the folding of newly synthesised polypeptides in the crowded cellular environment
ACL_RS06180	this protein is required for the folding of newly synthesised polypeptides in the crowded cellular environment
ACL_RS06190	probable amino acid transport system
ACL_RS06195	probable amino acid transport system
ACL_RS06200	putative copper transporting ATPase
ACL_RS06220	ATPase, putative
ACL_RS06230	heavy metal cation transporting ATPase, putative
ACL_RS06255	YolD-like proteins were predicted to be functionally equivalent to the UmuD subunit of polymerase V from Gram-negative bacteria
ACL_RS06260	DNA damage repair protein
ACL_RS06280	type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. Type I enzymes have three different subunits subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzyme with restriction, methylase and ATPase activities
ACL_RS06290	type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. Type I enzymes have three different subunits subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzyme with restriction, methylase and ATPase activities
ACL_RS06295	type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. Type I enzymes have three different subunits subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzyme with restriction, methylase and ATPase activities
ACL_RS06340	this transporter is active in low external Mg2+ concentrations and pump the ion into the cytoplasm
ACL_RS06355	spermidine/putrescine transport system compound
ACL_RS06360	spermidine/putrescine transport system compound
ACL_RS06365	spermidine/putrescine transport system compound
ACL_RS06380	ribonucleoside-diphosphate reductase catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides: It provides the precursors necessary for DNA synthesis
ACL_RS06385	ribonucleoside-diphosphate reductase catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides: It provides the precursors necessary for DNA synthesis
ACL_RS07540	ribonucleoside-diphosphate reductase catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides: It provides the precursors necessary for DNA synthesis
ACL_RS06395	this enzyme produces a glycine-centred radical in the ribonucleotide triphosphate reductase (anaerobic)
ACL_RS06405	putative 6-aminohexanoate-dimer hydrolase
ACL_RS06420	signal transduction
ACL_RS06425	DNA-binding response regulator
ACL_RS06430	PhoU is a regulatory protein of unknown mechanism for high-affinity phosphate ABC transporter systems
ACL_RS06435	phosphate transport system
ACL_RS06440	phosphate transport system
ACL_RS06450	phosphate transport system
ACL_RS06455	putative transporter
ACL_RS06460	putative multidrug resistance transport system
ACL_RS06470	this protein catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes
ACL_RS06480	dihydrolipoamide dehydrogenase is a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system
ACL_RS06485	pyruvate/2-oxoglutarate dehydrogenase complex E2 component
ACL_RS06515	agmatinase hydrolyses agmatine to putrescine, the precursor for the biosynthesis of higher polyamines, spermidine and spermine
ACL_RS06520	lysine decarboxylase catalyses the removal of COOH groups from lysine using pyridoxal phosphate as a co-factor
ACL_RS06530	this is a DNA repair enzyme that excises uracil residues from DNA by cleaving the N-glycosylic bond. Uracil in DNA can arise as a result of misincorportation of dUMP residues by DNA polymerase or deamination of cytosine
ACL_RS06540	GTP cyclohydrolase II (RibA, [EC: 3.5.4.25]) catalyses the first committed step in the biosynthesis of riboflavin. The enzyme converts GTP and water to formate, 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)- pyrimidine and pyrophosphate, and requires magnesium as a cofactor. The RibB protein (3,4-dihydroxy-2-butanone 4-phosphate synthase) synthesizes 3,4-dihydroxy-2-butanone 4-phosphate that serves as the biosynthetic precursor for the xylene ring of riboflavin
ACL_RS06550	putative amino acid transport system
ACL_RS06555	putative amino acid transport system
ACL_RS06560	putative amino acid transport system
ACL_RS06570	polyprenyl synthetase enzymes catalyze a 1'4-condensation between 5 carbon isoprene units
ACL_RS06575	this protein contains GGDEF and PAS domains. GGDEF domain function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule in a wide variety of bacteria. PAS domains are also involved in many signalling proteins where they are used as a signal sensor domain.
ACL_RS06595	this protein is involved in purine ribonucleotide biosynthesis
ACL_RS06635	this protein transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of pp-binding. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP
ACL_RS06645	this enzyme reduces oxidised thioredoxin in the presence of NADPH
ACL_RS06655	this is the sensor in a multicomponent phosphorelay system in control of carbohydrate metabolism
ACL_RS06665	nucleotide excision repair complex
ACL_RS06670	this enzyme catalyzes the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing NAD(+) as a cofactor
ACL_RS06675	REP family helicases catalyse ATP dependent unwinding of double stranded DNA to single stranded DNA
ACL_RS06685	UvrD is involved in promoting the post-incision steps of nucleotide excision repair, including turnover of the UvrBC incision complex
ACL_RS06700	this enzyme cleaves proteins that are heavily sialylated
ACL_RS06705	this enzyme catalyses the acetylation of the N-terminal alanine of ribosomal protein S18
ACL_RS06720	this enzyme is involved in glycolysis and in gluconeogenesis and catalyse the conversion of D-glucose 6-phosphate to D-fructose 6-phosphate
ACL_RS06755	5-formyltetrahydrofolate cyclo-ligase (or methenyl-THF synthetase) catalyses the interchange of 5-formyltetrahydrofolate (5-FTHF) to 5-10-methenyltetrahydrofolate, this requires ATP and Mg2+
ACL_RS06760	GGDEF domain function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule in a wide variety of bacteria
ACL_RS06790	this enzyme catalyzes the hydrolysis of all of the commonly occuring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates
ACL_RS06795	ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway
ACL_RS06815	this enzyme catalyses the reduction of the 5,6-double bond of a uridine residue on tRNA. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA.
ACL_RS06840	Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea
ACL_RS06845	probable cell cycle control RR-type ATPase
ACL_RS06855	probable cell division protease
ACL_RS06900	putative fructose bisphosphate aldolase, a glycolytic enzyme that catalyzes the reversible aldol cleavage or condensation of fructose-1,6-bisphosphate into dihydroxyacetone-phosphate and glyceraldehyde 3-phosphate
ACL_RS06905	this enzyme hydrolyzes the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent ammonia to the acceptor substrate at the synthetase domain to form an aminated product
ACL_RS06925	this protein seems to play a role in a recombinational process of DNA repair
ACL_RS06935	the full-length product of the dnaX gene in E. coli encodes the DNA polymerase III tau subunit. A translational frameshift leads to early termination and a truncated protein subunit gamma, about 1/3 shorter than tau and present in roughly equal amounts
ACL_RS06940	this protein may play a role in tRNA processing and may be directly or indirectly involved in regulating ribosome function
ACL_RS06955	DHH family proteins are predicted to perform a phosphoesterase function
ACL_RS06975	putative sugar transport system
ACL_RS06980	putative sugar transport system
ACL_RS06985	putative sugar transport system
ACL_RS07360	putative sugar transport system
ACL_RS07000	this enzyme catalyzes the conversion of two molecules of geranylgeranyl diphosphate into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate
ACL_RS07005	this protein is an enzyme of carotenoid biosynthesis that converts phytoene into zeta-carotene via the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene
ACL_RS07025	this protein provides the protection against damage from endogenously-formed hydroxyperoxides, catalyses the reduction of hydroxyperoxides by glutathione
ACL_RS07045	dak2 domain is the predicted phosphatase
ACL_RS07055	this is a DNA repair enzyme. It binds to UV-damaged DNA containing pyrimidine dimers and, upon absorbing a near-UV photon (300 to 500 nm), breaks the cyclobutane ring joining the two pyrimidines of the dimer
ACL_RS07075	predicted RNA binding protein
ACL_RS07085	RNAse P is a site specific endonuclease that generates mature tRNAs by cleaving-off the leader sequences at their 5'ends. In bacteria RNase P is known to be composed of two components: a large (about 400 base pairs) RNA (gene rnpB) and a small protein (119 to 133 amino acids) (gene rnpA)