-- dump date   	20140618_184116
-- class       	Genbank::CDS
-- table       	cds_function
-- id	function
YP_001620021.1	this protein binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of replication (oriC)
YP_001620024.1	this is a DNA binding protein that assists the filamentation of RecA onto DNA for the initiation of recombination or recombinational repair
YP_001620025.1	DNA gyrase is ATP-dependent enzyme that primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II consists of two polypeptide subunits, gyrA and gyrB, which form a heterotetramer: (BA)2
YP_001620026.1	DNA gyrase is ATP-dependent enzyme that primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II consists of two polypeptide subunits, gyrA and gyrB, which form a heterotetramer: (BA)2
YP_001620031.1	nucleotide-binding protein
YP_001620032.1	this protein is a member of pdu operon that function is to degrade 1,2-propanediol by a pathway that requires coenzyme B12, adenosylcobalamin (AdoCbl). Exact function of the PduL protein is not yet determined
YP_001620034.1	putative ribonuclease M5
YP_001620035.1	this enzyme catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine to two adjacent adenosine bases in 16S rRNA
YP_001620038.1	this protein cleaves peptidyl-tRNA or N-acyl-aminoacyl-tRNA to yield free peptides or N-acyl-amino acids and tRNA
YP_001620039.1	this protein is a DNA-dependent ATPase, DNA repair enzyme
YP_001620044.1	glycerophospholipid metabolism
YP_001620047.1	this enzyme catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA
YP_001620048.1	this enzyme is a radical-SAM domain protein that oxidizes a single glycine residue in the Pfl protein to the corresponding radical by transfer of a proton from its CH2 to AdoMet with concomitant cleavage of the latter
YP_001620051.1	this protein one of the enzymes participating in the transfer of one-carbon units, an essential element of various biosynthetic pathways. In many of these processes the transfers of one-carbon units are mediated by the coenzyme tetrahydrofolate
YP_001620055.1	putative sugar transport system
YP_001620056.1	putative sugar transport system
YP_001620058.1	OsmC (osmotically inducible protein) is a stress -induced protein found in E.coli
YP_001620061.1	this enzyme is responsible for the hydrolysis of pyrophosphate which is formed principally as the product of the many biosynthetic reactions that utilize ATP
YP_001620065.1	this protein catalyses the transfer of a hydroxymethyl group from N5, N10- methylene tetrahydrofolate to glycine, resulting in the formation of serine and tetrahydrofolate. Enzyme is pyridoxal phosphate dependent
YP_001620066.1	putative electron transport complex
YP_001620067.1	putative electron transport complex
YP_001620070.1	putative electron transport complex
YP_001620071.1	probable RnafA subunit of the NADH oxidoreductase complex RnfABCDGE type
YP_001620072.1	this enzyme may be involved in the conversion of aminoimidazole ribotide to 4-amino-5-hydroxymethyl-2-methyl pyrimidine during the biosynthesis of the pyrimidine moiety of thiamine
YP_001620076.1	this protein is an ubiquitous enzyme that catalyzes the ATP-dependent phosphorylation of thymidine
YP_001620079.1	transketolase catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways.
YP_001620080.1	function of this highly conserved protein is not yet known
YP_001620081.1	this protein is a predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division
YP_001620084.1	this protein catalyzes the NAD+-dependent oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde of the valine catabolism pathway
YP_001620109.1	this protein is a component of the preprotein translocase pathway, that allows secretion across the membrane
YP_001620110.1	this enzyme is a phosphotransferase that catalyses the reversible reaction: AMP + MgATP = ADP + MgADP. This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates
YP_001620111.1	this protein catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides
YP_001620119.1	deoxyribonuclease I
YP_001620120.1	DNA damage repair protein
YP_001620121.1	this enzyme hydrolyses peptides of 7 and 17 amino acids with fairly broad specificity
YP_001620123.1	this protein reduces oxidised thioredoxin in the presence of NADPH. Reduced thioredoxin serves as an electron donor for thioredoxin peroxidase which consequently reduces H2O2 to H2O.
YP_001620124.1	thioredoxins are small disulphide-containing redox proteins that serve as a general protein disulphide oxidoreductase.
YP_001620125.1	probable cobalt transport system
YP_001620126.1	probable cobalt transport system
YP_001620127.1	probable cobalt transport system
YP_001620128.1	this protein catalyzes the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)
YP_001620129.1	this enzyme catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP): ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. Thymidylate kinase is important in the dTTP synthesis pathway for DNA synthesis
YP_001620131.1	putative RNA methyltransferase
YP_001620132.1	putative S-adenosyl-dependent methyl transferase
YP_001620138.1	extracellular C-terminal part of this protein contains PAS and GGDEF domains, both involved in signal transduction
YP_001620147.1	P-ATPases function to transport a variety of different compounds, including ions and phospholipids, across a membrane using ATP hydrolysis for energy
YP_001620153.1	this protein is a transcriptional elongation factor involved in transcription termination and anti-termination, interacting with the termination factor Rho and RNA polymerase
YP_001620156.1	this endonuclease is sequence independent, dsDNA-specific. Biological role is unknown.
YP_001620157.1	endonuclease I (EC:3.1.21.-) is extracellular, sequence- independent, dsDNA-specific endonuclease. Its biological role is unknown.
YP_001620162.1	endonuclease I (EC:3.1.21.-) is extracellular, sequence- independent, dsDNA-specific endonuclease. Its biological role is unknown.
YP_001620172.1	rRNA (guanine-N2-)-methyltransferase
YP_001620176.1	C-terminal part of this protein contains GGDEF domain that synthesizes cyclic di-GMP, which is used as an intracellular signalling molecule.
YP_001620198.1	predicted signaling protein part contains GGDEF and DHH domains
YP_001620200.1	Dps (DNA protection during starvation) proteins exhibit nonspecific DNA-binding activity that is at least partially linked with iron complexation. DNA bound by these proteins was shown to suffice for protection against oxidative DNA damage and might be mediated by magnesium ions, which bridge the protein surfaces with the polyanionic DNA. Stress-inducible proteins.
YP_001620201.1	such proteins reduce chromate accumulation and are essential for chromate resistance.
YP_001620202.1	such proteins reduce chromate accumulation and are essential for chromate resistance.
YP_001620203.1	RF-1 helps to recognise and terminate translation at UAA and UAG stop codons.
YP_001620204.1	similar to the methylase of polypeptide chain release factors
YP_001620206.1	ribosome binding protein, which GTPase activity is stimulated by the large ribosomal subunit
YP_001620208.1	this protein catalyzes conversion of uracil to uridine 5'-monophosphate utilizing 5'-phosphoribosyl--1-pyrophosphate. UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.
YP_001620210.1	poly(A) polymerase family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase (EC:2.7.7.19), which adds the poly (A) tail to mRNA. This family also includes the tRNA nucleotidyltransferase (EC:2.7.7.25) that adds the CCA to the 3' of the tRNA.
YP_001620213.1	beta-lactamase catalyses the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins
YP_001620214.1	similar to predicted methyltransferase
YP_001620215.1	Mscl proteins forms a channel organized as a homopentamer. Such channels play a critical role in transducing physical stresses at the cell membrane (e.g. stretch force in the membrane) into a electrochemical response. May participate in the regulation of osmotic pressure changes
YP_001620217.1	DAHP (3-deoxy-D-arabino-heptulosonate-7-phosphate) synthase catalyzes the first step in aromatic amino acid biosynthesis from chorismate. DAHP synthase is a metal -activated enzyme, which is the target for negative-feedback regulation by pathway intermediates or by end products.
YP_001620218.1	this protein catalyses oxidative decarboxylation of prephenate to 4-hydroxyphenylpyruvate
YP_001620219.1	this protein catalyses the formation of dehydroquinate (DHQ) and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate (DAHP). This reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids
YP_001620220.1	3-phosphoshikimate 1-carboxyvinyltransferase (EPSP synthase) catalyzes the sixth step in the biosynthesis from chorismate of the aromatic amino acids (the shikimate pathway).
YP_001620221.1	this protein catalyses the rearrangement of chorismate to prephenate, the reaction at the branch point of the biosynthetic pathway leading to the three aromatic amino acids, phenylalanine, tryptophan and tyrosine (chorismic acid is the last common intermediate, and CM leads to the L-phenylalanine/L-tyrosine branch)
YP_001620222.1	this protein catalyses the fourth step of the shikimate pathway, which is the NADP-dependent reduction of 3-dehydroshikimate to shikimate
YP_001620223.1	this protein catalyzes the last of the seven steps in the shikimate pathway. It catalyzes the 1,4-trans elimination of the phosphate group from 5-enolpyruvylshikimate-3-phosphate (EPSP) to form chorismate which can then be used in phenylalanine, tyrosine or tryptophan biosynthesis
YP_001620225.1	this protein catalyzes the synthesis of coenzyme A and mevalonate in isoprenoid synthesis
YP_001620226.1	this protein catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to produce HMG-CoA and CoA
YP_001620228.1	this protein participates in recombination and DNA repair. It helps to process Holliday junction intermediates to mature products by catalysing branch migration. RecG has DNA unwinding activity characteristic of a DNA helicase with 3' to 5' polarity
YP_001620230.1	the main function of this protein is in the processing of pre-rRNAs, the maturation and degradation of mRNAs, and the maturaton of tRNAs
YP_001620232.1	endonuclease III is a DNA repair enzyme which removes a number of damaged pyrimidines from DNA via its glycosylase activity and also cleaves the phosphodiester backbone at apurinic / apyrimidinic sites via a beta-elimination mechanism. The structurally related DNA glycosylase MutY recognises and excises the mutational intermediate 8-oxoguanine-adenine mispair
YP_001620237.1	flavodoxins are electron-transfer proteins that function in various electron transport systems. They bind one FMN molecule, which serves as a redox-active prosthetic group and are functionally interchangeable with ferredoxins
YP_001620243.1	this is the central protein in the diverse metabolic pathways, mainly in the fatty acid synthesis system and the polyketide synthesis
YP_001620247.1	radical SAM proteins catalyze diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S-adenosylmethionine (SAM) through an unusual Fe-S center
YP_001620251.1	phenylalanyl-tRNA synthetase is an alpha2/beta2 tetramer
YP_001620252.1	phenylalanyl-tRNA synthetase is an alpha2/beta2 tetramer
YP_001620253.1	radical SAM proteins catalyze diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S-adenosylmethionine (SAM) through an unusual Fe-S center
YP_001620254.1	possible ribosome small subunit associated GTPase
YP_001620255.1	this enzyme converts D-ribulose 5-phosphate into D-xylulose 5-phosphate in Calvin's reductive pentose phosphate cycle
YP_001620256.1	this protein catalyses the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the enzyme cofactor thiamine pyrophosphate (TPP, coenzyme B1)
YP_001620258.1	this protein (also known as dihydroxyacetone kinase) catalyses the phosphorylation of glycerone in the presence of ATP to glycerone phosphate in the glycerol utilization pathway
YP_001620263.1	probable regulator of genes involved in phosphosugar metabolism
YP_001620265.1	O-glycosyl hydrolases hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety
YP_001620268.1	beta-lactamase catalyses the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins
YP_001620269.1	Ig-like domains are usually found in cell surface proteins. N-acetylmuramoyl-L-alanine amidase cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala)
YP_001620271.1	putative sugar transport system
YP_001620272.1	putative sugar transport system
YP_001620273.1	putative sugar transport system
YP_001620274.1	putative sugar transport system
YP_001620276.1	putative sugar transport system
YP_001620277.1	putative sugar transport system
YP_001620280.1	O-glycosyl hydrolases hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety
YP_001620281.1	this protein catalyses reaction: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate. This is the first enzyme in the metabolism of N-acetylglucosamine
YP_001620282.1	this protein catalyses reaction: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate
YP_001620284.1	this protein catalyses the conversion of D-glucosamine 6-phosphate and water to D-fructose 6-phosphate in the N-acetylglucosamine utilization pathway
YP_001620286.1	this protein catalyses the second step in glycosylphosphatidylinositol (GPI) biosynthesis
YP_001620296.1	EF-G (or EF2) is responsible for the translocation of the peptidyl-tRNA from the A-site to the P-site (peptidyl-tRNA site) of the ribosome, thereby freeing the A-site for the next aminoacyl-tRNA to bind. GTPase
YP_001620300.1	superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Their function is to destroy the radicals that are normally produced within cells and are toxic to biological systems
YP_001620301.1	fibronectin is a part of extracellular matrix and has critical roles in eukaryotic cellular processes, such as adhesion, migration and differentiation, it is also a substrate for the attachment of bacteria (e.g. fibronectin binding is considered to be an important virulence factor in streptococcal infections).
YP_001620302.1	this protein catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP.
YP_001620303.1	the omega subunit is required to promote RNAP assembly by acting like a chaperone to maintain beta' in the correct conformation and to recruit it to the alpha(2)beta subassembly to form a functional core enzyme
YP_001620304.1	DNA damage excision repair system includes uvrA, uvrB, and uvrC gene products
YP_001620309.1	this enzyme is responsible for the anomeric interconversion of D-glucose and other aldoses between their alpha- and beta-forms.
YP_001620312.1	this protein removes the ammonia group from a glutamate molecule and transfers it to a specific substrate, thus creating a new carbon-nitrogen group on the substrate.
YP_001620313.1	this protein catalyses the reversible transfer of an adenylyl group from ATP to 4'-phosphopantetheine to give dephospho-CoA (DPCOA) and pyrophosphate in the fourth (and penultimate) step of coenzyme A biosynthesis.
YP_001620315.1	nusA (N utilisation substance protein A) binds to RNA polymerase alpha subunit and promotes termination at certain RNA hairpin structures.
YP_001620318.1	IF-2 promotes the GTP-dependent binding of the initiator tRNA to the small subunit of the ribosome
YP_001620319.1	RbfA associates with free 30S ribosomal subunits, but not with 30S subunits that are part of 70S ribosomes or polysomes. It is essential for efficient processing of 16S rRNA
YP_001620322.1	this protein, also known as replication factor Y (superfamily II helicase), is a component of the primosome which is involved in replication, repair, and recombination
YP_001620323.1	this protein transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP.
YP_001620326.1	this protein catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is an important methyl donor for transmethylation and is also the propylamino donor in polyamine biosynthesis.
YP_001620327.1	exact function of LemA protein is unknown. Small N-terminal part of the protein is extracellular, while the most part of protein is cytosolic.
YP_001620329.1	there is a conserved real translational frameshift at a TGA codon. RF-2 helps to terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient
YP_001620336.1	proteins of this family are involved in the degradation of the ribonucleotide moiety on RNA-DNA hybrid molecules carrying out endonucleolytic cleavage to 5'-phospo-monoester. This family also includes Ribonuclease HIII.
YP_001620337.1	type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap
YP_001620344.1	this protein plays protective antioxidant role in cells through its peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified. None cofactors are needed in contrast to other peroxidases.
YP_001620345.1	the signal recognition particle (SRP) mediates the protein transport to or across the membrane. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognated receptor (SR)
YP_001620346.1	homologs of this protein are often part of operons that encode components of the SRP pathway, and this protein may regulate the expression of an operon related to the SRP pathway
YP_001620347.1	the signal recognition particle (SRP) mediates the protein transport to or across the membrane. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognated receptor (SR).
YP_001620348.1	this protein also contains 3#-5# and 5#-3# exonuclease domains both. The former is responsible for the 3'-5' exonuclease proofreading activity, catalyzing the hydrolysis of unpaired or mismatched nucleotides. The 5'-3' exonuclease domain is involved in structure-specific cleavage of flaps formed by Pol I activity
YP_001620349.1	N-terminal part of this protein is the formamidopyrimidine-DNA glycosylase (EC: 3.2.2.23), a DNA repair enzyme that excises oxidised purines from damaged DNA. The shorter C-terminal part of this protein is the dephospho-CoA kinase (EC: 2.7.1.24) that catalyzes the final step in CoA biosynthesis (the phosphorylation of dephosphocoenzyme A (dCoA) to CoA)
YP_001620350.1	this protein is essential for both replication initiation and membrane attachment of the origin region of the chromosome
YP_001620354.1	this protein is similar to the Na+ efflux pump
YP_001620358.1	this protein plays a role in repair of DNA damage after UV and X-ray irradiation
YP_001620363.1	this protein associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation
YP_001620367.1	RuvA, RuvB, and RuvC proteins process the universal DNA intermediate of homologous recombination, termed Holliday junction
YP_001620368.1	RuvA, RuvB, and RuvC proteins process the universal DNA intermediate of homologous recombination, termed Holliday junction
YP_001620369.1	this protein is required for the synthesis of the queuosine precursor (oQ). Q (queuosine) is a hypermodified nucleoside usually found at the first position of the anticodon of asparagine, aspartate, histidine, and tyrosine tRNAs
YP_001620370.1	this hydrophobic integral membrane protein provides resistance to the antibiotic bacitracin
YP_001620371.1	the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) is a major carbohydrate transport system in bacteria. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. Sugar-specific permease consists of at least three structurally distinct domains (IIA, IIB, and IIC)
YP_001620372.1	the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) is a major carbohydrate transport system in bacteria. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. Sugar-specific permease consists of at least three structurally distinct domains (IIA, IIB, and IIC).
YP_001620374.1	putative tRNA (guanine-N(7)-)-methyltransferase
YP_001620376.1	NADPH-dependent oxidoreductase
YP_001620377.1	topoisomerase IV primarily decatenates DNA and relaxes positive supercoils
YP_001620378.1	topoisomerase IV primarily decatenates DNA and relaxes positive supercoils
YP_001620386.1	putative sugar ABC transporter
YP_001620387.1	putative sugar ABC transporter
YP_001620388.1	these enzymes catalyze the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA
YP_001620392.1	this protein is a part of the glycine decarboxylase multienzyme complex. The reaction catalysed by P-protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
YP_001620393.1	this protein is a part of the glycine decarboxylase multienzyme complex. The reaction catalysed by P-protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
YP_001620394.1	this protein is a part of the glycine decarboxylase multienzyme complex. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
YP_001620395.1	this protein is a part of the glycine decarboxylase multienzyme complex
YP_001620399.1	this enzyme (2-phospho-D-glycerate hydrolase) catalyses the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways
YP_001620400.1	this enzyme catalyzes the conversion of dihydroxyacetone phosphate to methylglyoxal and phosphate: Glycerone phosphate = methylglyoxal + phosphate. It provides bacteria with an alternative to triosephosphate isomerase for metabolizing dihydroxyacetone phosphate
YP_001620403.1	SsrA RNA recognizes ribosomes stalled on defective messages and acts as a tRNA and mRNA to mediate the degradation of the partially synthesized nascent polypeptide chain. SmpB protein is an essential component of the SsrA quality-control system. SmpB binds specifically and with high affinity to SsrA RNA and is required for stable association of SsrA with ribosomes in vivo
YP_001620408.1	this protein contains one endonuclease domain and two helicase domains
YP_001620410.1	this protein is similar to fructokinases, which catalyze the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate
YP_001620417.1	NADP-dependent alcohol dehydrogenases with a wide variety of substrate specificities
YP_001620418.1	chaperones protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates
YP_001620419.1	this protein is similar to glycolate oxidase, GlcD (EC 1.1.3.15 ), that preferentially oxidizes short-chain aliphatic hydroxy acids
YP_001620420.1	the phnA homolog in E. coli is a part of a large operon associated with alkylphosphonate uptake and carbon-phosphorus bond cleavage
YP_001620425.1	P-ATPases function to transport a variety of different compounds, including ions and phospholipids, across a membrane using ATP hydrolysis for energy
YP_001620427.1	The PTS (phosphoenolpyruvate-dependent sugar phosphotransferase) system is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars. One subunit of the PTS system is membrane-bound complex EII with sugar-specific permease activity. EII consists of at least three structurally distinct domains IIA, IIB and IIC. IIA domain carries the first permease-specific phosphorylation site, a histidine which is phosphorylated by phospho-HPr.
YP_001620433.1	PTS (phosphoenolpyruvate-dependent sugar phosphotransferase) system is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars. EI- enzyme I.
YP_001620434.1	The Fic (Filamentation induced by cAMP) protein was described in E. coli. The Fic protein is involved in the synthesis of p-aminobenzoate or folate. The Fic protein and cAMP were supposed to be involved in a new regulatory mechanism of cell division via folate metabolism
YP_001620436.1	this protein catalyses the methylation of conserved uracil residue at position 54 of tRNA molecule
YP_001620443.1	C-terminal part of this protein contains GGDEF domain that synthesizes cyclic di-GMP, which used as an intracellular signalling molecule
YP_001620445.1	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Majority of VWA-containing proteins are extracellular. A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands.
YP_001620447.1	C-terminal part of this protein contains GGDEF domain that synthesizes cyclic di-GMP, which used as an intracellular signalling molecule
YP_001620448.1	ATPases of P-type transport a variety of different compounds, including ions and phospholipids, across a membrane using ATP hydrolysis for energy
YP_001620452.1	this protein is a subunit of the acetyl-CoA carboxylase complex, that catalyzes the first step in the synthesis of long-chain fatty acids, which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association.
YP_001620453.1	this protein is a subunit of the acetyl-CoA carboxylase complex, that catalyzes the first step in the synthesis of long-chain fatty acids, which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association
YP_001620454.1	this protein is a subunit of the acetyl-CoA carboxylase complex, that catalyzes the first step in the synthesis of long-chain fatty acids, which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association
YP_001620455.1	this protein is a subunit of the acetyl-CoA carboxylase complex, that catalyzes the first step in the synthesis of long-chain fatty acids, which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association
YP_001620456.1	this protein initiates elongation in fatty acid biosynthesis. It is responsible for producing the multitude of fatty acid structures found in bacterial membranes
YP_001620457.1	this protein is involved in fatty acid biosynthesis and transfers the malonyl moeity from coenzyme A to acyl-carrier protein.
YP_001620458.1	fatty acid biosynthesis ptotein
YP_001620459.1	this enzyme catalyzes the condensation of malonyl-ACP with the growing fatty acid chain. This protein is a component of a number of enzymatic systems, e.g. fatty acid synthetase (FAS), which catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH
YP_001620460.1	FabZ is the primary dehydratase involved in fatty-acid elongation in the fatty acid biosynthesis of type II. It catalyses the dehydration of beta-hydroxyacyl acyl carrier protein (ACP) to trans 2-enoyl ACP
YP_001620461.1	this protein (also known as holocarboxylase synthetase) catalyses the covalent attachment of the biotin prosthetic group to a specific lysine of the biotin carboxyl carrier domain of biotin-dependent carboxylases in a two-step reaction
YP_001620462.1	thioredoxin reductase reduces oxidised thioredoxin in the presence of NADPH. Reduced thioredoxin serves as an electron donor for thioredoxin peroxidase which consequently reduces H2O2 to H2O.
YP_001620466.1	putative spermidine/putrescine transport system
YP_001620467.1	putative spermidine/putrescine transport system
YP_001620468.1	putative spermidine/putrescine transport system
YP_001620469.1	putative spermidine/putrescine transport system
YP_001620470.1	NusB protein is involved in the regulation of rRNA biosynthesis by transcriptional antitermination
YP_001620471.1	exonuclease VII catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield 5'-phosphomononucleotides
YP_001620472.1	exonuclease VII catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield 5'-phosphomononucleotides
YP_001620474.1	RecN is a DNA damage inducible protein involved in recombinational processes
YP_001620475.1	damage-inducible DNA polymerase with a very high error rate
YP_001620476.1	ATP-dependent RNA unwinding is needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation
YP_001620482.1	this enzyme synthesizes the major nonbilayer-prone membrane lipid alpha-monoglucosyldiacylglycerol in A.laidlawii. This protein is related to a large group of lipid glycosyltransferases and has homologs in related pathogenic bacteria. This enzyme is probably attached to the membrane by charge-charge and hydrophobic interactions
YP_001620484.1	such enzymes are involved in the maintenance of the appropriate protein tyrosine phosphorylation level that is essential for many cellular functions (e.g. signal transduction, cell cycle control, proliferation). Tyrosine-specific phosphatases catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. Low molecular weight protein-tyrosine phosphatases (or acid phosphatase) act on tyrosine phosphorylated proteins, low molecular weight aryl phosphates and natural and synthetic acyl phosphates
YP_001620486.1	this is the first enzyme in the NAD salvage synthesis from nicontinate (niacin). PncB catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid
YP_001620487.1	MATE (Multi Antimicrobial Extrusion) family proteins function as drug/sodium antiporters. These proteins mediate resistance to a wide range of cationic dyes, fluroquinolones, aminoglycosides and other structurally diverse antibodies and drugs
YP_001620488.1	this protein is involved in tRNA and rRNA base modification
YP_001620490.1	this enzyme is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate
YP_001620491.1	branched-chain amino acid transport system
YP_001620492.1	branched-chain amino acid transport system
YP_001620493.1	branched-chain amino acid transport system
YP_001620494.1	branched-chain amino acid transport system
YP_001620495.1	branched-chain amino acid transport system
YP_001620497.1	this protein performes thiolysis of acetoacetyl-CoA and is involved in biosynthetic pathways such as poly beta-hydroxybutyrate synthesis or steroid biogenesis
YP_001620498.1	3-ketoacyl-acyl carrier protein reductase (FabG) is involved in type II fatty acid biosynthesis
YP_001620499.1	beta-ketoacyl-acyl carrier protein synthase III (FabH), in general, initiates elongation in type II fatty acid synthase system and is responsible for producing the multitude of fatty acid structures found in bacterial membranes
YP_001620500.1	acetyl-CoA hydrolase catalyses the formation of acetate from acetyl-CoA
YP_001620503.1	this protein is related to the tRNA (uracil-5-)-methyltransferase
YP_001620506.1	DEAD box RNA helicase
YP_001620507.1	this protein is related to the tRNA (uracil-5-)-methyltransferase
YP_001620512.1	this enzyme uses ADP-glucose as the glucose donor
YP_001620513.1	GlgC is involved in the glycogen synthesis pathway. GlgC is also called ADP-glucose pyrophosphorylase
YP_001620514.1	Ig-like folded domains are usually found in bacterial surface proteins such as intimins. Intimin is a bacterial cell-adhesion molecule that mediates the intimate bacterial host-cell interaction
YP_001620523.1	this protein is an 1,4-alpha-glucan branching enzyme responsible for the transfer of chains of approximately seven alpha(1,4)-linked glucosyl residues to other similar chains (in new alpha-(1,6) linkages) in the biosynthesis of glycogen. The branching enzyme is responsible for the degree of alpha(1,6) branch linkages found in polysaccharides
YP_001620527.1	members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars
YP_001620529.1	the trigger factor is involved in protein export. Trigger factor is a ribosome-associated molecular chaperone and is the first chaperone interacting with nascent polypeptide and maintaining its open conformation
YP_001620530.1	the Lon serine proteases hydrolyse ATP to degrade protein substrates. In E. coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock
YP_001620531.1	YihA from E.coli is an essential protein involved in cell division control. Homologs of yihA are found in most Gram(+) and Gram(-) pathogenic bacteria, with the exception of Mycobacterium tuberculosis
YP_001620536.1	this is an ATP-dependent enzyme responsible for the addition of a polyglutamate tail to folate and folate derivatives. Plays a key role in the retention of the intracellular folate pool
YP_001620537.1	this protein catalyses the release of fatty acids from lysophsopholipids
YP_001620538.1	the Major Facilitator Superfamily (MFS) transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. MFS includes uniporters, symporters or antiporters of diverse specificity
YP_001620543.1	molecular chaperones protect proteins in the intracellular milieu from irreversible aggregation during synthesis and in times of cellular stress. DnaK is a component of he DnaK-DnaJ-GrpE chaperone system. GrpE is nucleotide exchange factor, stimulating the rate of ADP release 5000-fold.
YP_001620544.1	molecular chaperones protect proteins in the intracellular milieu from irreversible aggregation during synthesis and in times of cellular stress. DnaK is a component of he DnaK-DnaJ-GrpE chaperone system.
YP_001620545.1	molecular chaperones protect proteins in the intracellular milieu from irreversible aggregation during synthesis and in times of cellular stress. DnaK is a component of he DnaK-DnaJ-GrpE chaperone system.
YP_001620546.1	lipoic acid is the covalently attached cofactor of several multi-component enzyme complexes that catalyze key metabolic reactions. LplA catalyzes the attachment of lipoic acids to the target proteins
YP_001620547.1	predicted metal-binding, possibly nucleic acid-binding protein
YP_001620549.1	this protein is involved in cell envelope biogenesis
YP_001620550.1	N-terminal part of this protein is plsC (1-acyl-sn-glycerol-3-phosphate acyltransferase, EC 2.3.1.51) involved in lipid metabolism, while C-terminal part is occupied with Fur (ferric uptake regulator)
YP_001620551.1	this protein is an indispensable enzyme in the biosynthesis of NAD(+) and NADP(+). This enzyme synthesizes the immediate precursor of NAD
YP_001620552.1	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis. This protein contains NAD-synthase domain and an additional N-terminal amidohydrolase domain that prefer glutamine. Such two-domain structure of NAD-synthase is typical to eukaryotes and some prokaryotes
YP_001620553.1	this protein is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs. Catalyses reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate
YP_001620554.1	RecD is part of a RecBCD complex
YP_001620555.1	this protein is similar to phospholipase/carboxylesterase family
YP_001620556.1	this protein is involved in phenylalanine biosynthesis. This protein catalyses the decarboxylation of prephenate to phenylpyruvate
YP_001620562.1	this protein is highly similar to diadenosine hexa- (Ap6A) or tetraphosphate (Ap4A) hydrolases of NUDIX superfamily. NUDIX hydrolases (NUcleoside DIphosphate linked to some other moiety X) require a divalent cation, such as Mg2+ or Mn2+ for their activity
YP_001620563.1	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase (trmA)
YP_001620568.1	this protein catalyses the formation of cyclic AMP/GMP(cAMP/cGMP) from ATP/GTP
YP_001620573.1	serine recombinases perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases
YP_001620577.1	XerD and XerC are integrases, site-specific DNA breaking-rejoining enzymes with tyrosine active sites. Many integrases are associated with various mobile DNA elements (e.g. phages). In E. coli the XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids
YP_001620582.1	DNA restriction-modification mechanisms protect the organism against invading foreign DNA. Sequence-specific
YP_001620583.1	DNA restriction-modification mechanisms protect the organism against invading foreign DNA. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system
YP_001620584.1	DNA restriction-modification mechanisms protect the organism against invading foreign DNA. Sequence-specific
YP_001620587.1	E. coli plasmid protein ParB preferentially cleaves ssDNA. ParB also nicks supercoiled plasmid DNA preferably at sites with potential single-stranded character, like AT-rich regions and sequences that can form cruciform structures. ParB also exhibits 5--3 exonuclease activity
YP_001620593.1	this enzyme synthesizes S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is an important methyl donor for transmethylation and is also the propylamino donor in polyamine biosynthesis
YP_001620601.1	Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. Terminase large subunit possesses an endonuclease and ATPase activity
YP_001620603.1	the portal proteins form a channel through which the viral DNA is packaged into the capsid, and exits during infection
YP_001620605.1	this protein is similar to putative phage capsid proteins from Bacillus spp
YP_001620621.1	lysis protein that contains two predicted largely hydrophobic helices at the N-terminus
YP_001620625.1	McrBC system mediates sequence-specific restriction of cytosine-modified DNA. McrB has GTPase activity and high affinity to methylated DNA
YP_001620626.1	McrBC system mediates sequence-specific restriction of cytosine-modified DNA
YP_001620629.1	this protein participates in post-transcriptional control of mRNA stability and translational efficiency. It is also involved in the processing and maturation of ribosomal RNA precursors, and processing of phage and plasmid transcripts.
YP_001620632.1	phospholipid biosynthesis protein
YP_001620633.1	this protein catalyses the Na(+)-dependent uptake of extracellular glutamate
YP_001620635.1	putative antimicrobial peptide transport system
YP_001620637.1	lipid metabolism
YP_001620638.1	this enzyme synthesizes pseudouridine from uracil in ribosomal RNA
YP_001620639.1	this enzyme synthesizes pseudouridine from uridine-516 in 16S ribosomal RNA
YP_001620640.1	putative transporter
YP_001620641.1	arginine transport system
YP_001620642.1	arginine transport system
YP_001620643.1	arginine transport system
YP_001620644.1	putative transporter
YP_001620645.1	short-chain alcohol dehydrogenase of unknown specificity
YP_001620646.1	oxidation of critical methionine residues leads to inactivation of many proteins. Methionine sulfoxide reductase B reduces B-stereoisomers of methionine sulfoxides during oxidative stress response
YP_001620647.1	this protein transfers a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan
YP_001620648.1	alpha-amylase is an essential enzyme in alpha-glucan metabolism, acting to catalyse the hydrolysis of alpha-1,4-glucosidic bonds of glycogen, starch and related polysaccharides
YP_001620649.1	alpha-amylase is an essential enzyme in alpha-glucan metabolism, acting to catalyse the hydrolysis of alpha-1,4-glucosidic bonds of glycogen, starch and related polysaccharides
YP_001620650.1	alpha-amylase is an essential enzyme in alpha-glucan metabolism, acting to catalyse the hydrolysis of alpha-1,4-glucosidic bonds of glycogen, starch and related polysaccharides
YP_001620651.1	sugar transport system
YP_001620652.1	sugar transport system
YP_001620653.1	sugar transport system
YP_001620659.1	alpha-amylase is an essential enzyme in alpha-glucan metabolism, acting to catalyse the hydrolysis of alpha-1,4-glucosidic bonds of glycogen, starch and related polysaccharides
YP_001620660.1	sugar transport system
YP_001620662.1	this protein protects cell against damage from endogenously-formed hydroxyperoxides, catalyses the reduction of hydroxyperoxides by glutathione: 2 Glutathione + H2O(2) = oxidised Glutathione + 2H2O
YP_001620663.1	N-terminal transmembrane anchor of this protein is followed by the CBS domain that binds ligands with an adenosyl group such as AMP, ATP and S-AdoMet. C-terminal domain is CorC_HlyC region, that is associated with various transporters
YP_001620665.1	Multi-domain protein. N-terminal domain forms the transmembrane anchor. The second domain is diguanylate-cyclase (DGC) or GGDEF domain, followed by the conserved C-terminal regulatory enzyme domain with catalytic activity of the metal dependent phosphohydrolase
YP_001620668.1	LepA has the unique function of back-translocating posttranslocational ribosomes. LepA recognizes ribosomes after a defective translocation reaction and induces a back-translocation, thus giving EF-G a second chance to translocate the tRNAs correctly
YP_001620670.1	this protein replaces HemF function under anaerobic conditions. HemN catalyses the anaerobic transformation of coproporhyrinogen-III into protoporphyrinogen-IX during porphyrin biosynthesis
YP_001620671.1	DNA breaking-rejoining enzyme. Contains tyrosine active site. Interacts with XerC
YP_001620672.1	this protein is involved in the purine and pyrimidine salvage pathway of nucleotide synthesis. It catalyses a phosphotransfer on ribose and deoxyribose, converting D-ribose 1-phosphate to D-ribose 5-phosphate, and 2-deoxy-D-ribose 1-phosphate to 2-deoxy-D-ribose 5-phosphate
YP_001620675.1	this enzyme nonverts thymidine (and to a lesser extent, 2'-deoxyuridine) to thymine (or uracil) and 2'-deoxyribose-1-phosphate
YP_001620678.1	monovalent cation/H+ antiporter
YP_001620681.1	phospholipid/glycerol acyltransferase
YP_001620682.1	this enzyme reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-methylenetetrahydrofolate which is then utilized by thymidylate synthase
YP_001620683.1	this enzyme catalyzes the reductive methylation of dUMP to dTMP with concomitant conversion of 5,10-methylenetetrahydrofolate to dihydrofolate: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. This provides the sole de novo pathway for production of dTMP and is the only enzyme in folate metabolism in which the 5,10-methylenetetrahydrofolate is oxidised during one-carbon transfer. The enzyme is essential for regulating the balanced supply of the 4 DNA precursors in normal DNA replication
YP_001620684.1	metal-dependent aminoacylase, which catalyse the final step in arginine biosynthesis
YP_001620686.1	this protein binds with high affinity to ssDNA and protect ssDNA intermediates during DNA metabolic pathways
YP_001620690.1	this enzyme is involved in the salvage of nucleotides and nucleosides
YP_001620691.1	this enzyme catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2-deoxyribose 5-phosphate. Deoxyribose-phophate aldolase appears to function in the catabolism of deoxyribonucleotides
YP_001620697.1	YchF may function as a GTP-dependent translational factor. YchF possess the TGS domain related to the RNA-binding proteins
YP_001620698.1	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells
YP_001620699.1	queuine tRNA-ribosyltransferases are also known as tRNA-guanine transglycosylase and guanine insertion enzyme. TGT modifies tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine
YP_001620702.1	nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor
YP_001620709.1	this protein is also known as glucan endo-1,3-beta-D-glucosidase. Hydrolyzes 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans such as laminarins, curdlans, paramylons, and pachymans, with very limited action on mixed-link (1,3-1,4-)-beta-D-glucans
YP_001620710.1	sugar transport system
YP_001620711.1	sugar transport system
YP_001620712.1	sugar transport system
YP_001620714.1	sugar transport system
YP_001620715.1	sugar transport system
YP_001620716.1	sugar transport system
YP_001620719.1	this protein is also known as glucan endo-1,3-beta-D-glucosidase. Hydrolyzes 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans such as laminarins, curdlans, paramylons, and pachymans, with very limited action on mixed-link (1,3-1,4-)-beta-D-glucans
YP_001620723.1	DsbA is a bacterial protein-folding factor for disulfide bonded secreted proteins.FrnE is a DsbA-like protein containing a CXXC motif. FrnE is presumed to be a dithiol-disulfide isomerase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins
YP_001620725.1	this enzyme cleaves medium sized peptides
YP_001620731.1	this protein increases tolerance to divalent metal ions such as cadmium, zinc, and cobalt. Protein forms efflux pump that remove these ions from cells
YP_001620732.1	2-nitropropane dioxygenase is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN
YP_001620734.1	ZIP family protein (divalent heavy-metal cations transporters)
YP_001620735.1	transcriptional repressor, may serve as global regulator
YP_001620739.1	this enzyme accelerates protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YP_001620745.1	rhodanese is a sulphurtransferase involved in cyanide detoxification
YP_001620747.1	rhodanese is a sulphurtransferase involved in cyanide detoxification
YP_001620753.1	probable GNAT family member
YP_001620755.1	this enzyme catalyzes the NADPH-dependent reduction of ammonia and L-2-amino-6-ketopimelate to form meso-diaminopimelate, the direct precursor of L-lysine
YP_001620757.1	this protein is related to diketogluconate reductase.
YP_001620760.1	members of this family are drug/sodium antiporters that mediate resistance to a wide range of cationic dyes, fluroquinolones, aminoglycosides and other structurally diverse antibodies and drugs
YP_001620764.1	putative multidrug resistance transport system
YP_001620765.1	putative multidrug resistance transport system
YP_001620766.1	putative multidrug resistance transport system
YP_001620768.1	tryptophan synthase catalyzes the last step in the biosynthesis of tryptophan: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O
YP_001620771.1	this protein is involved in a specialized system that confers resistance to Hg(II) on catalysing the reaction: Hg(II) + NADPH=Hg(0) + NADP + H
YP_001620777.1	DapB is involved in the biosynthesis of diaminopimelic acid, a component of bacterial cell walls, and the essential amino acid L-lysine. It catalyses generation of the tetrahydrodipicolinate: 2,3-dihydrodipicolinate + NAD(P)H = 2,3,4,5-tetrahydrodipicolinate + NAD(P)(+)
YP_001620778.1	this protein is the key enzyme in lysine biosynthesis via the diaminopimelate pathway. Catalyses the condensation of L-aspartate-beta-semialdehyde and pyruvate to dihydropicolinic acid
YP_001620779.1	this enzyme converts aspartyl phosphate to aspartate-semialdehyde
YP_001620780.1	this enzyme catalyzes the phosphorylation of aspartate. The latter can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine
YP_001620781.1	this enzyme catalyzes the final step in the lysine biosynthetic pathway converting meso-diaminopimelic acid (DAP) to L-lysine
YP_001620783.1	GGDEF domain function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule
YP_001620784.1	this enzyme catalyzes the irreversible and NADPH-dependent reductive deamination of GMP into IMP (inosine 5'-monophosphate). It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides
YP_001620785.1	ACP thioesterases terminate fatty acyl group extension via hydrolyzing an acyl group on a fatty acid
YP_001620788.1	this enzyme catalyses the interconversion of isopentenyl diphosphate and dimethylallyl diphosphate. Dimethylallyl phosphate is the initial substrate for the biosynthesis of carotenoids and other long chain isoprenoids
YP_001620789.1	this enzyme catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway
YP_001620790.1	this enzyme catalyzes the decarboxylation of mevalonate pyrophosphate to isopentyl pyrophosphate (IPP), the last step in the synthesis of IPP in the mevalonate pathway.Catalyzed reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2
YP_001620792.1	this enzyme accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues
YP_001620793.1	uncharacterized enzyme, probably involved in pigment biosynthesis
YP_001620794.1	putative magnesium transporter
YP_001620798.1	this enzyme can process single-stranded RNA, but is stalled by double-stranded structures such as stem-loops. Was found in degradosomes
YP_001620801.1	riboflavin is converted into catalytically active cofactors (FAD and FMN) by the actions of riboflavin kinase (EC:2.7.1.26), which converts it into FMN, and FAD synthetase (EC:2.7.7.2), which adenylates FMN to FAD
YP_001620802.1	this protein catalyzes the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Usually it makes psi55 in the T loop of tRNAs
YP_001620803.1	thioredoxin alters the redox state of proteins and in such a way regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors
YP_001620804.1	mismatch repair ATPase
YP_001620805.1	this protein cleaves RNA from DNA-RNA hybrids. It catalyses endonucleolytic cleavage to 5'-phospho-monoesters
YP_001620807.1	this enzyme is responsible for synthesis of pseudouridine from uracil in 23S rRNA
YP_001620811.1	this enzyme hydrolyzes dCMP into dUMP
YP_001620812.1	this enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine
YP_001620817.1	this enzyme appears to be able to cleave any D-amino acid (and glycine, which does not have distinct D/L forms) from charged tRNA
YP_001620821.1	this is ATP-independent intracellular protease that may hydrolyze small peptides to provide a nutritional source
YP_001620823.1	this protein is required for DNA recombination and repair
YP_001620829.1	this enzyme is responsible for the synthesis of UDP-glucose, a key compound in the biosynthesis of polysaccharides
YP_001620834.1	putative multidrug resistance transport system
YP_001620835.1	putative multidrug resistance transport system
YP_001620839.1	phosphoglucomutase (EC:5.4.2.2) is responsible for the conversion of D-glucose 1-phosphate to D-glucose 6-phosphate. The enzyme participates in both the breakdown and synthesis of glucose. Phosphomannomutase (EC:5.4.2.8) is involved in the conversion of D-mannose 1-phosphate to D-mannose 6-phosphate
YP_001620840.1	putative regulatory protein
YP_001620851.1	glutamine amidotransferase activity involves the removal of the ammonia group from a glutamate molecule and its subsequent transfer to a specific substrate, thus creating a new carbon-nitrogen group on the substrate
YP_001620856.1	choline kinase catalyses the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway
YP_001620861.1	the exact function of these proteins is not yet clear but they are capable of wrapping DNA and stabilizing it from denaturation under extreme environmental conditions
YP_001620862.1	this enzyme catalyzes the conversion of glycerol-3-phosphate into dihydroxyacetone phosphate
YP_001620865.1	this enzyme catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors
YP_001620866.1	this enzyme is responsible for synthesis of pseudouridine from uracil in ribosomal RNA
YP_001620868.1	this enzyme catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway (biosynthesis of aromatic amino acids from chorismate) and the catabolic quinate pathway
YP_001620869.1	this enzyme catalyzes the fifth step in the biosynthesis of aromatic amino acids from chorismate (the so-called shikimate pathway). The enzyme catalyzes the following reaction: ATP + shikimate = ADP + shikimate-3-phosphate
YP_001620870.1	this enzyme modifies tRNAs at A(37) to give isopentenyl A(37)
YP_001620871.1	this protein together with the MutS protein is a key component of the DNA repair machinery that corrects replication errors. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signalling complex for repair
YP_001620872.1	this protein together with the MutL protein is a key component of the DNA repair machinery that corrects replication errors. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signalling complex for repair
YP_001620875.1	probable hydrolase
YP_001620877.1	putative multidrug resistance transport system
YP_001620878.1	putative multidrug resistance transport system
YP_001620879.1	multifunctional enzyme that plays a role in homologous recombination, DNA repair and induction of the SOS response. In homologous recombination, the protein functions as a DNA-dependent ATPase, promoting synapsis, heteroduplex formation and strand exchange between homologous DNAs
YP_001620880.1	this enzyme catalyses the conversion ofCDP-diacylglycerol and glycerol-3-phosphate to CMP and 3-(3-phosphatidyl)-glycerol 1-phosphate in the biosynthesis of acidic phospholipids
YP_001620884.1	bipartite protein. N-terminal part contains seven predicted transmembrane helices, that could be essential for bacterial competence in uptake of extracellular DNA. C-terminal part of this protein is ComEC hydrolase of metallo-beta-lactamase superfamily
YP_001620885.1	extracellular surface-anchored protein; DNA binding and uptake
YP_001620890.1	GreA promotes transcription elongation by stimulating an endogenous, endonucleolytic transcript cleavage activity of the RNA polymerase (RNAP). This protein induces cleavage of 3'-RNA fragments 2A#3 nt in length and can only prevent the formation of arrested complexes
YP_001620899.1	GGDEF domain function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule
YP_001620900.1	this protein exchanges Na+ for H+ in an electroneutral manner, and this activity is carried out by a family of Na+/H+ exchangers. This antiporter eject protons from cells, effectively eliminating excess acid from actively metabolising cells
YP_001620901.1	this protein reduces chromate accumulation and is essential for chromate resistance
YP_001620928.1	putative lipid A export transport system
YP_001620931.1	DNA primase synthesizes the RNA primers for the Okazaki fragments in lagging strand DNA synthesis
YP_001620933.1	this protein is required for the damage avoidance-tolerance pathway(s). The RecO protein may contain a mononucleotide-binding fold
YP_001620935.1	this is a small homotetrameric zinc metalloprotein, that may act on deoxycytidine as well as cytidine
YP_001620937.1	ATPase, predicted
YP_001620941.1	putative enterochelin transport system
YP_001620942.1	putative enterochelin transport system
YP_001620943.1	putative enterochelin transport system
YP_001620944.1	putative enterochelin transport system
YP_001620948.1	this enzyme catalyses the first step in the pentose pathway, i.e. the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH
YP_001620949.1	this is an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways (PPP)
YP_001620950.1	putative divalent metal ion transporter
YP_001620951.1	putative divalent metal ion transporter
YP_001620952.1	NADH:quinone oxidoreductase respiratory complex
YP_001620953.1	FMN-binding domain protein of the NADH:quinone oxidoreductase respiratory complex
YP_001620954.1	NADH:quinone oxidoreductase respiratory complex
YP_001620955.1	NADH:quinone oxidoreductase respiratory complex
YP_001620956.1	NADH:quinone oxidoreductase respiratory complex
YP_001620957.1	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The D subunit appears to be located in the central stalk of V1 complex
YP_001620958.1	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The B subunits along with the A subunits form the catalytic core of the V1 complex
YP_001620959.1	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The A subunits along with the B subunits form the catalytic core of the V1 complex
YP_001620967.1	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. Subunit epsilon may be important for for connecting the rotor of F1 (gamma subunit) to the rotor of F0 (C subunit)
YP_001620968.1	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. Beta subunits along with the alpha subunits form the catalytic core of the F1 complex
YP_001620969.1	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. Gamma subunit forms the central shaft that connects the F0 rotary motor to the F1 catalytic core
YP_001620970.1	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. Alpha subunits along with the beta subunits form the catalytic core of the F1 complex
YP_001620971.1	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. This subunit appears to be part of the peripheral stalk that holds the F1 complex alpha3beta3 catalytic core stationary against the torque of the rotating central stalk, and links subunit A of the F0 complex with the F1 complex
YP_001620972.1	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. This subunit appears to be part of the peripheral stalk that holds the F1 complex alpha3beta3 catalytic core stationary against the torque of the rotating central stalk, and links subunit A of the F0 complex with the F1 complex
YP_001620973.1	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. Ten C subunits form an oligomeric ring that makes up the F0 rotor
YP_001620974.1	F-ATPases are composed of two linked complexes: the F1 ATPase complex is the catalytic core, while the F0 ATPase complex is the membrane-embedded proton channel. The subunit A is a key component of the proton channel, and may play a direct role in the translocation of protons across the membrane
YP_001620979.1	probable multidrug transport system
YP_001620980.1	probable multidrug transport system
YP_001620984.1	this protein is a tripeptide aminopeptidase with a substrate preference for hydrophobic peptides
YP_001620990.1	mechanosensitive channels provide protection against hypo-osmotic shock, responding both to stretching of the cell membrane and to membrane depolarisation
YP_001620993.1	putative extracellular peptidase S26B
YP_001620996.1	putative extracellular peptidase S26B
YP_001621000.1	this protein contains GGDEF and EAL domains, both involved in the signal transduction. In particular, GGDEF domain function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule, while EAL domain is a candidate for a diguanylate phosphodiesterase function in diverse bacterial signaling proteins
YP_001621001.1	this protein contains EAL domain, which is a candidate for a diguanylate phosphodiesterase function in diverse bacterial signaling protein.
YP_001621006.1	putative lipopolysaccharide biosynthesis protein
YP_001621007.1	this enzyme hydrolyses peptides of 7 and 17 amino acids with fairly broad specificity
YP_001621009.1	this protein is a DNA helicase that functions in the nucleotide excision repair and is a endonuclease that makes the 3' incision next to DNA damage
YP_001621011.1	NAD-binding protein
YP_001621012.1	integral membrane component
YP_001621014.1	this protein is NAD-dependent enzyme that catalyzes the final step in anaerobic glycolysis in which pyruvate is converted to L-lactate
YP_001621022.1	this enzyme catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc
YP_001621023.1	this enzyme converts glucosamine-6-phosphate to glucosamine-1-phosphate as part of the pathway toward UDP-N-acetylglucosamine for peptidoglycan and lipopolysaccharides
YP_001621024.1	possible polysaccharide transport protein
YP_001621025.1	this enzyme catalyses the production of UDP-ManNAc from UDP-GlcNAc
YP_001621029.1	this enzyme catalyses the production of UDP-ManNAc from UDP-GlcNAc
YP_001621034.1	putative carbamoylphosphate synthase large subunit
YP_001621038.1	this protein interconverts UDP-glucose and UDP-galactose which are precursors of glucose- and galactose-containing exopolysaccharides
YP_001621048.1	this enzyme is responsible for the conversion of D-glucose 1-phosphate to D-glucose 6-phosphate. The enzyme participates in both the breakdown and synthesis of glucose
YP_001621050.1	ROK (Repressor, ORF, Kinase) family groups transcriptional repressors, sugar kinases and yet uncharacterized ORFs. This family includes N-acetylglucosamine repressor, nagC, from E. coli; glucokinase EC:2.7.1.2 from Streptomyces coelicolor; fructokinase EC:2.7.1.4 from Streptococcus mutans. The repressor proteins contains N-terminal HTH DNA-binding domain
YP_001621052.1	probable sugar transport system
YP_001621053.1	probable sugar transport system
YP_001621054.1	probable sugar transport system
YP_001621055.1	ATP-dependent DNA helicase, uvrD-type
YP_001621058.1	this protein is a member of a distinct group of short helix-turn-helix proteins. This group includes the characterized member HigA, without which the killer protein HigB cannot be cloned. The hig (host inhibition of growth) system is noted to be unusual in that killer protein is encoded by the upstream member of the gene pair
YP_001621059.1	several plasmids with proteic killer gene systems have been reported. All of them encode a stable toxin and an unstable antidote. Upon loss of the plasmid, the less stable inhibitor is inactivated more rapidly than the toxin, allowing the toxin to be activated. The activation of those systems result in cell filamentation and cessation of viable cell production. It has been verified that both the stable killer and the unstable inhibitor of the systems are short polypeptides. This family corresponds to the toxin
YP_001621068.1	this protein recognises the double-stranded unmethylated sequence GATC and cleaves before G-1
YP_001621069.1	this is probable N-4 cytosine-specific or N-6 adenine-specific DNA methylase
YP_001621071.1	serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme
YP_001621072.1	this protein catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic pyrophosphate (PPi). MutT pyrophosphohydrolase is important in preventing errors in DNA replication by hydrolyzing mutagenic nucleotides such as 8-oxo-dGTP (a product of oxidative damage), which can mispair with template adenine during DNA replication, to guanine nucleotides
YP_001621076.1	this enzyme catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP: ADP + phosphoenolpyruvate = ATP + pyruvate
YP_001621077.1	this enzyme catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6- bisphosphate, a key regulatory step in the glycolytic pathway
YP_001621078.1	this enzyme catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6- bisphosphate, a key regulatory step in the glycolytic pathway
YP_001621079.1	glutamate dehydrogenases are a broadly distributed group of enzymes that catalyse the reversible oxidative deamination of glutamate to ketoglutarate and ammonia
YP_001621081.1	this protein catalyzes the NAD-dependent reversible reductive amination of pyruvate into alanine
YP_001621083.1	metal ion uptake regulatory protein
YP_001621084.1	metal ions transport system
YP_001621085.1	metal ions transport system
YP_001621086.1	metal ion binding lipoprotein
YP_001621087.1	this protein function is the repair of DNA containing O6-alkylated guanine by transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. Protein is also able to repair O-4-methylthymine
YP_001621090.1	LrgA and LrgB proteins are both thought to control murein hydrolase activity and penicillin tolerance
YP_001621091.1	LrgA protein has been hypothesised to export murein hydrolases
YP_001621092.1	bifunctional protein: diaminohydroxyphosphoribosylaminopyrimidine deaminase / aminodioxyphosphoribosylaminopyrimidine reductase
YP_001621093.1	electron transfer flavoproteins serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. Electron transfer flavoproteins are heterodimeric proteins composed of an alpha and beta subunit, and contain an FAD cofactor and AMP
YP_001621094.1	electron transfer flavoproteins serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. Electron transfer flavoproteins are heterodimeric proteins composed of an alpha and beta subunit, and contain an FAD cofactor and AMP
YP_001621100.1	peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process
YP_001621109.1	this protein participates in cell protection from stress by controlling the aggregation and denaturation of vital cellular structures
YP_001621110.1	this family consists of the N-terminal region of exopolyphosphatase (Ppx) [EC:3.6.1.11] and guanosine pentaphosphate phospho-hydrolase (GppA) [EC:3.6.1.40]
YP_001621112.1	this protein contains GGDEF and EAL domains that both participate in signal transduction. GGDEF domain function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule. EAL domain is found in diverse bacterial signalling proteins and is a good candidate for a diguanylate phosphodiesterase function.
YP_001621116.1	probable heavy metal ion transporting ATPase
YP_001621117.1	probable metal ion transporting ATPase
YP_001621118.1	glutamine amidotransferase activity involves the removal of the ammonia group from a glutamate molecule and its subsequent transfer to a specific substrate, thus creating a new carbon-nitrogen group on the substrate. PfpI, is a putative intracellular cysteine protease. DJ-1 was previously described in eukaryotes as oncogene
YP_001621119.1	this enzyme is involved in the recycling of the components of S-adenosylmethionine after it has donated one of its two non-ribose sulphur ligands to an acceptor. In the case when 5'-methylthioadenosine is used as the substrate the corresponding reaction is the first step of the methionine salvage pathway in bacteria
YP_001621120.1	uridine kinase catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP
YP_001621124.1	putative phosphatidate cytidylyltransferase [EC:2.7.7.41], that catalyzes the synthesis of CDP-diacylglycerol from CTP and phosphatidate (PA): CDP-diacylglycerol is an important branch point intermediate.
YP_001621125.1	this enzyme generates undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_001621126.1	this enzyme catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction
YP_001621129.1	this protein dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. RRF is believed to bind the ribosome at the A-site in a manner that mimics tRNA, but the specific mechanisms remain unclear
YP_001621130.1	this protein converts UMP to UDP by adding a phosphate from ATP. It is the first step in pyrimidine biosynthesis
YP_001621133.1	dUTPase hydrolyzes dUTP to dUMP and pyrophosphate, simultaneously reducing dUTP levels and providing the dUMP for dTTP biosynthesis. dUTPase decreases the intracellular concentration of dUPT so that uracil cannot be incorporated into DNA
YP_001621135.1	XerD-like integrases are DNA breaking-rejoining enzymes involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid inheritance
YP_001621136.1	the function of gid proteins is unknown. They are closely related to gidA (glucose-inhibited division protein A)
YP_001621137.1	members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The superfamily can be subdivided into two major groups: water-selective channels called aquaporins and glycerol uptake facilitators
YP_001621140.1	this protein is a DNA repair enzyme that excises uracil residues from DNA by cleaving the N-glycosylic bond. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or deamination of cytosine
YP_001621141.1	probable peptidase, S24 family
YP_001621142.1	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The D subunit appears to be located in the central stalk of V1 complex
YP_001621143.1	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The B subunits along with the A subunits form the catalytic core of the V1 complex
YP_001621144.1	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The A subunits along with the B subunits form the catalytic core of the V1 complex
YP_001621146.1	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The F subunit is part of V1 complex and is required for the assembly and activity of V-ATPase
YP_001621148.1	the V-ATPases are composed of two linked complexes: the V1 complex contains the catalytic core that hydrolyses/synthesizes ATP, and the V0 complex that forms the membrane-spanning pore. The I subunit is found in the V0 complex and is a transmembrane glycoprotein required for the assembly and proton transport activity of the ATPase complex
YP_001621151.1	this enzyme plays an important role in glycolysis and gluconeogenesis by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-diphospho-glycerate
YP_001621155.1	this protein catalyzes the reduction of arsenate to arsenite, and thus extends resistance to include arsenate that is basically provided by ArsA and ArsB genes
YP_001621156.1	this enzyme hydrolyses peptides of 7 and 17 amino acids with fairly broad specificity
YP_001621158.1	this protein contains GGDEF and EAL domains that both participate in signal transduction. GGDEF domain function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule. EAL domain is found in diverse bacterial signalling proteins and is a good candidate for a diguanylate phosphodiesterase function
YP_001621163.1	tRNA (guanine-N1-)-methyltransferase is one of several nucleases operating together with the tRNA-modifying enzymes before the formation of the mature tRNA. It catalyses the reaction: methylating guanosine(G) to N1-methylguanine (1-methylguanosine (m1G)) at position 37 of tRNAs that read CUN (leucine), CCN(proline), and CGG (arginine) codons
YP_001621164.1	this protein is essential for efficient processing of 16S rRNA
YP_001621169.1	this protein catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis
YP_001621173.1	this protein is required for thiazole synthesis in the thiamine biosynthesis pathway
YP_001621174.1	putative GAF sensor protein
YP_001621176.1	N-acetylglucosaminylphosphatidylinositol deacetylase (EC:3.5.1.89) catalyzes the second step in glycosylphosphatidylinositol-anchor biosynthesis
YP_001621179.1	this protein reduces oxidised thioredoxin in the presence of NADPH. Reduced thioredoxin serves as an electron donor for thioredoxin peroxidase which consequently reduces H2O2 to H2O
YP_001621181.1	this protein is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate
YP_001621182.1	the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) is a major carbohydrate transport system in bacteria. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. Sugar-specific permease consists of at least three structurally distinct domains (IIA, IIB, and IIC).
YP_001621184.1	this protein is an enzyme that catalyses the formation of ATP to ADP and vice versa. In the second step of the second phase in glycolysis, 1,3-diphosphoglycerate is converted to 3-phosphoglycerate, forming one molecule of ATP
YP_001621188.1	sulphur assimilation protein complex
YP_001621189.1	sulphur assimilation protein complex
YP_001621190.1	sulphur assimilation protein complex
YP_001621191.1	sulphur assimilation protein complex
YP_001621192.1	sulphur assimilation protein complex, ABC transport system ATPase component
YP_001621194.1	putative oligopeptide transport system
YP_001621195.1	putative oligopeptide transport system
YP_001621196.1	putative oligopeptide transport system
YP_001621197.1	putative oligopeptide transport system
YP_001621198.1	putative oligopeptide transport system
YP_001621203.1	this enzyme catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia
YP_001621209.1	uncharacterized transport system
YP_001621210.1	uncharacterized transport system
YP_001621211.1	uncharacterized transport system
YP_001621212.1	mutidrug resistance transport system
YP_001621213.1	mutidrug resistance transport system
YP_001621214.1	Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system
YP_001621222.1	this protein is required for the folding of newly synthesised polypeptides in the crowded cellular environment
YP_001621223.1	this protein is required for the folding of newly synthesised polypeptides in the crowded cellular environment
YP_001621225.1	probable amino acid transport system
YP_001621226.1	probable amino acid transport system
YP_001621227.1	putative copper transporting ATPase
YP_001621228.1	extracellular domain has putative restriction endonuclease activity
YP_001621231.1	ATPase, putative
YP_001621233.1	heavy metal cation transporting ATPase, putative
YP_001621238.1	YolD-like proteins were predicted to be functionally equivalent to the UmuD subunit of polymerase V from Gram-negative bacteria
YP_001621239.1	DNA damage repair protein
YP_001621244.1	type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. Type I enzymes have three different subunits subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzyme with restriction, methylase and ATPase activities
YP_001621246.1	type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. Type I enzymes have three different subunits subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzyme with restriction, methylase and ATPase activities
YP_001621247.1	type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. Type I enzymes have three different subunits subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzyme with restriction, methylase and ATPase activities
YP_001621252.1	this transporter is active in low external Mg2+ concentrations and pump the ion into the cytoplasm
YP_001621254.1	spermidine/putrescine transport system compound
YP_001621255.1	spermidine/putrescine transport system compound
YP_001621256.1	spermidine/putrescine transport system compound
YP_001621257.1	spermidine/putrescine transport system compound
YP_001621260.1	ribonucleoside-diphosphate reductase catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides: It provides the precursors necessary for DNA synthesis
YP_001621261.1	ribonucleoside-diphosphate reductase catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides: It provides the precursors necessary for DNA synthesis
YP_001621262.1	ribonucleoside-diphosphate reductase catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides: It provides the precursors necessary for DNA synthesis
YP_001621263.1	this enzyme produces a glycine-centred radical in the ribonucleotide triphosphate reductase (anaerobic)
YP_001621265.1	putative 6-aminohexanoate-dimer hydrolase
YP_001621268.1	signal transduction
YP_001621269.1	DNA-binding response regulator
YP_001621270.1	PhoU is a regulatory protein of unknown mechanism for high-affinity phosphate ABC transporter systems
YP_001621271.1	phosphate transport system
YP_001621272.1	phosphate transport system
YP_001621273.1	phosphate transport system
YP_001621274.1	phosphate transport system
YP_001621275.1	putative transporter
YP_001621276.1	putative multidrug resistance transport system
YP_001621278.1	this protein catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes
YP_001621280.1	dihydrolipoamide dehydrogenase is a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system
YP_001621281.1	pyruvate/2-oxoglutarate dehydrogenase complex E2 component
YP_001621285.1	RelE and RelB proteins form a toxin-antitoxin system; RelE represses translation, probably through binding ribosomes. RelB stably binds RelE, presumably deactivating it
YP_001621287.1	agmatinase hydrolyses agmatine to putrescine, the precursor for the biosynthesis of higher polyamines, spermidine and spermine
YP_001621288.1	lysine decarboxylase catalyses the removal of COOH groups from lysine using pyridoxal phosphate as a co-factor
YP_001621290.1	this is a DNA repair enzyme that excises uracil residues from DNA by cleaving the N-glycosylic bond. Uracil in DNA can arise as a result of misincorportation of dUMP residues by DNA polymerase or deamination of cytosine
YP_001621292.1	GTP cyclohydrolase II (RibA, [EC: 3.5.4.25]) catalyses the first committed step in the biosynthesis of riboflavin. The enzyme converts GTP and water to formate, 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)- pyrimidine and pyrophosphate, and requires magnesium as a cofactor. The RibB protein (3,4-dihydroxy-2-butanone 4-phosphate synthase) synthesizes 3,4-dihydroxy-2-butanone 4-phosphate that serves as the biosynthetic precursor for the xylene ring of riboflavin
YP_001621294.1	putative amino acid transport system
YP_001621295.1	putative amino acid transport system
YP_001621296.1	putative amino acid transport system
YP_001621298.1	polyprenyl synthetase enzymes catalyze a 1'4-condensation between 5 carbon isoprene units
YP_001621299.1	this protein contains GGDEF and PAS domains. GGDEF domain function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule in a wide variety of bacteria. PAS domains are also involved in many signalling proteins where they are used as a signal sensor domain.
YP_001621302.1	this protein is involved in purine ribonucleotide biosynthesis
YP_001621309.1	this protein transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of pp-binding. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP
YP_001621311.1	this enzyme reduces oxidised thioredoxin in the presence of NADPH
YP_001621312.1	prolipoprotein diacylglyceryl transferase (lgt) catalyzes the first step in lipoprotein biogenesis, it transfers the n-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins. The Lgt forms an integral membrane domain that localizes at the N-terminal part of this protein. C-terminal part is occupied with the putative phosphatase domain
YP_001621313.1	this is the sensor in a multicomponent phosphorelay system in control of carbohydrate metabolism
YP_001621315.1	nucleotide excision repair complex
YP_001621316.1	this enzyme catalyzes the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing NAD(+) as a cofactor
YP_001621317.1	REP family helicases catalyse ATP dependent unwinding of double stranded DNA to single stranded DNA
YP_001621319.1	UvrD is involved in promoting the post-incision steps of nucleotide excision repair, including turnover of the UvrBC incision complex
YP_001621322.1	this enzyme cleaves proteins that are heavily sialylated
YP_001621323.1	this enzyme catalyses the acetylation of the N-terminal alanine of ribosomal protein S18
YP_001621326.1	this enzyme is involved in glycolysis and in gluconeogenesis and catalyse the conversion of D-glucose 6-phosphate to D-fructose 6-phosphate
YP_001621333.1	5-formyltetrahydrofolate cyclo-ligase (or methenyl-THF synthetase) catalyses the interchange of 5-formyltetrahydrofolate (5-FTHF) to 5-10-methenyltetrahydrofolate, this requires ATP and Mg2+
YP_001621334.1	GGDEF domain function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule in a wide variety of bacteria
YP_001621340.1	this enzyme catalyzes the hydrolysis of all of the commonly occuring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates
YP_001621341.1	ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway
YP_001621345.1	this enzyme catalyses the reduction of the 5,6-double bond of a uridine residue on tRNA. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA.
YP_001621350.1	Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea
YP_001621351.1	probable cell cycle control RR-type ATPase
YP_001621353.1	probable cell division protease
YP_001621362.1	putative fructose bisphosphate aldolase, a glycolytic enzyme that catalyzes the reversible aldol cleavage or condensation of fructose-1,6-bisphosphate into dihydroxyacetone-phosphate and glyceraldehyde 3-phosphate
YP_001621363.1	this enzyme hydrolyzes the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent ammonia to the acceptor substrate at the synthetase domain to form an aminated product
YP_001621367.1	this protein seems to play a role in a recombinational process of DNA repair
YP_001621369.1	the full-length product of the dnaX gene in E. coli encodes the DNA polymerase III tau subunit. A translational frameshift leads to early termination and a truncated protein subunit gamma, about 1/3 shorter than tau and present in roughly equal amounts
YP_001621370.1	this protein may play a role in tRNA processing and may be directly or indirectly involved in regulating ribosome function
YP_001621373.1	DHH family proteins are predicted to perform a phosphoesterase function
YP_001621377.1	putative sugar transport system
YP_001621378.1	putative sugar transport system
YP_001621379.1	putative sugar transport system
YP_001621380.1	putative sugar transport system
YP_001621382.1	this enzyme catalyzes the conversion of two molecules of geranylgeranyl diphosphate into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate
YP_001621383.1	this protein is an enzyme of carotenoid biosynthesis that converts phytoene into zeta-carotene via the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene
YP_001621387.1	this protein provides the protection against damage from endogenously-formed hydroxyperoxides, catalyses the reduction of hydroxyperoxides by glutathione
YP_001621391.1	dak2 domain is the predicted phosphatase
YP_001621393.1	this is a DNA repair enzyme. It binds to UV-damaged DNA containing pyrimidine dimers and, upon absorbing a near-UV photon (300 to 500 nm), breaks the cyclobutane ring joining the two pyrimidines of the dimer
YP_001621395.1	the RmuC is a DNA recombination protein, while it#s molecular function is unclear. It is suspected that it is either a structural protein that protects DNA against nuclease action, or is itself involved in DNA cleavage at the regions of DNA secondary structures
YP_001621397.1	predicted RNA binding protein
YP_001621399.1	RNAse P is a site specific endonuclease that generates mature tRNAs by cleaving-off the leader sequences at their 5'ends. In bacteria RNase P is known to be composed of two components: a large (about 400 base pairs) RNA (gene rnpB) and a small protein (119 to 133 amino acids) (gene rnpA)