-- dump date 20140618_184205 -- class Genbank::misc_feature -- table misc_feature_note -- id note 762376000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 762376000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 762376000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376000004 Walker A motif; other site 762376000005 ATP binding site [chemical binding]; other site 762376000006 Walker B motif; other site 762376000007 arginine finger; other site 762376000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 762376000009 DnaA box-binding interface [nucleotide binding]; other site 762376000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 762376000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 762376000012 putative DNA binding surface [nucleotide binding]; other site 762376000013 dimer interface [polypeptide binding]; other site 762376000014 beta-clamp/clamp loader binding surface; other site 762376000015 beta-clamp/translesion DNA polymerase binding surface; other site 762376000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 762376000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376000018 ATP binding site [chemical binding]; other site 762376000019 Mg2+ binding site [ion binding]; other site 762376000020 G-X-G motif; other site 762376000021 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 762376000022 anchoring element; other site 762376000023 dimer interface [polypeptide binding]; other site 762376000024 ATP binding site [chemical binding]; other site 762376000025 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 762376000026 active site 762376000027 putative metal-binding site [ion binding]; other site 762376000028 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762376000029 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376000030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376000031 DNA-binding site [nucleotide binding]; DNA binding site 762376000032 FCD domain; Region: FCD; pfam07729 762376000033 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 762376000034 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 762376000035 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376000036 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376000037 substrate binding pocket [chemical binding]; other site 762376000038 membrane-bound complex binding site; other site 762376000039 hinge residues; other site 762376000040 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376000041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376000042 dimer interface [polypeptide binding]; other site 762376000043 conserved gate region; other site 762376000044 putative PBP binding loops; other site 762376000045 ABC-ATPase subunit interface; other site 762376000046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376000047 dimer interface [polypeptide binding]; other site 762376000048 conserved gate region; other site 762376000049 putative PBP binding loops; other site 762376000050 ABC-ATPase subunit interface; other site 762376000051 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376000052 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376000053 Walker A/P-loop; other site 762376000054 ATP binding site [chemical binding]; other site 762376000055 Q-loop/lid; other site 762376000056 ABC transporter signature motif; other site 762376000057 Walker B; other site 762376000058 D-loop; other site 762376000059 H-loop/switch region; other site 762376000060 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 762376000061 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 762376000062 tetramer interface [polypeptide binding]; other site 762376000063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376000064 catalytic residue [active] 762376000065 aspartate aminotransferase; Provisional; Region: PRK06207 762376000066 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376000067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376000068 homodimer interface [polypeptide binding]; other site 762376000069 catalytic residue [active] 762376000070 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376000071 homotrimer interaction site [polypeptide binding]; other site 762376000072 putative active site [active] 762376000073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376000074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376000075 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376000076 putative effector binding pocket; other site 762376000077 dimerization interface [polypeptide binding]; other site 762376000078 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 762376000079 Isochorismatase family; Region: Isochorismatase; pfam00857 762376000080 catalytic triad [active] 762376000081 dimer interface [polypeptide binding]; other site 762376000082 conserved cis-peptide bond; other site 762376000083 Transmembrane secretion effector; Region: MFS_3; pfam05977 762376000084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000085 putative substrate translocation pore; other site 762376000086 Pirin-related protein [General function prediction only]; Region: COG1741 762376000087 Pirin; Region: Pirin; pfam02678 762376000088 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 762376000089 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 762376000090 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 762376000091 active site 762376000092 DoxX; Region: DoxX; pfam07681 762376000093 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376000094 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376000095 substrate binding pocket [chemical binding]; other site 762376000096 membrane-bound complex binding site; other site 762376000097 hinge residues; other site 762376000098 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376000099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376000100 dimer interface [polypeptide binding]; other site 762376000101 conserved gate region; other site 762376000102 putative PBP binding loops; other site 762376000103 ABC-ATPase subunit interface; other site 762376000104 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376000105 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376000106 Walker A/P-loop; other site 762376000107 ATP binding site [chemical binding]; other site 762376000108 Q-loop/lid; other site 762376000109 ABC transporter signature motif; other site 762376000110 Walker B; other site 762376000111 D-loop; other site 762376000112 H-loop/switch region; other site 762376000113 Amidase; Region: Amidase; cl11426 762376000114 Ectoine synthase; Region: Ectoine_synth; pfam06339 762376000115 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376000116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376000117 DNA-binding site [nucleotide binding]; DNA binding site 762376000118 FCD domain; Region: FCD; pfam07729 762376000119 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 762376000120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376000121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376000122 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 762376000123 putative substrate binding pocket [chemical binding]; other site 762376000124 putative dimerization interface [polypeptide binding]; other site 762376000125 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 762376000126 dimer interface [polypeptide binding]; other site 762376000127 putative metal binding site [ion binding]; other site 762376000128 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 762376000129 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376000130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376000131 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376000132 putative dimerization interface [polypeptide binding]; other site 762376000133 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376000134 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376000135 substrate binding pocket [chemical binding]; other site 762376000136 membrane-bound complex binding site; other site 762376000137 hinge residues; other site 762376000138 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376000139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376000140 dimer interface [polypeptide binding]; other site 762376000141 conserved gate region; other site 762376000142 putative PBP binding loops; other site 762376000143 ABC-ATPase subunit interface; other site 762376000144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376000145 dimer interface [polypeptide binding]; other site 762376000146 conserved gate region; other site 762376000147 putative PBP binding loops; other site 762376000148 ABC-ATPase subunit interface; other site 762376000149 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376000150 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376000151 Walker A/P-loop; other site 762376000152 ATP binding site [chemical binding]; other site 762376000153 Q-loop/lid; other site 762376000154 ABC transporter signature motif; other site 762376000155 Walker B; other site 762376000156 D-loop; other site 762376000157 H-loop/switch region; other site 762376000158 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 762376000159 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 762376000160 tetramer interface [polypeptide binding]; other site 762376000161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376000162 catalytic residue [active] 762376000163 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 762376000164 EamA-like transporter family; Region: EamA; pfam00892 762376000165 acylphosphatase; Provisional; Region: PRK14424 762376000166 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 762376000167 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 762376000168 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 762376000169 active site 762376000170 substrate binding site [chemical binding]; other site 762376000171 FMN binding site [chemical binding]; other site 762376000172 putative catalytic residues [active] 762376000173 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 762376000174 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 762376000175 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376000176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376000177 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 762376000178 cytosine deaminase; Validated; Region: PRK07572 762376000179 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 762376000180 active site 762376000181 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376000182 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 762376000183 TM-ABC transporter signature motif; other site 762376000184 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 762376000185 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376000186 TM-ABC transporter signature motif; other site 762376000187 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 762376000188 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 762376000189 Walker A/P-loop; other site 762376000190 ATP binding site [chemical binding]; other site 762376000191 Q-loop/lid; other site 762376000192 ABC transporter signature motif; other site 762376000193 Walker B; other site 762376000194 D-loop; other site 762376000195 H-loop/switch region; other site 762376000196 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 762376000197 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 762376000198 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 762376000199 putative ligand binding site [chemical binding]; other site 762376000200 Abi-like protein; Region: Abi_2; pfam07751 762376000201 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 762376000202 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 762376000203 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376000204 active site residue [active] 762376000205 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 762376000206 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 762376000207 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 762376000208 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 762376000209 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762376000210 NAD binding site [chemical binding]; other site 762376000211 putative active site [active] 762376000212 substrate binding site [chemical binding]; other site 762376000213 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376000214 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 762376000215 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 762376000216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376000217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376000218 major facilitator superfamily transporter; Provisional; Region: PRK05122 762376000219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000220 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 762376000221 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 762376000222 Proteins containing SET domain [General function prediction only]; Region: COG2940 762376000223 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 762376000224 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 762376000225 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376000226 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 762376000227 putative DNA binding site [nucleotide binding]; other site 762376000228 putative Zn2+ binding site [ion binding]; other site 762376000229 AsnC family; Region: AsnC_trans_reg; pfam01037 762376000230 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 762376000231 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376000232 PYR/PP interface [polypeptide binding]; other site 762376000233 dimer interface [polypeptide binding]; other site 762376000234 TPP binding site [chemical binding]; other site 762376000235 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376000236 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 762376000237 TPP-binding site [chemical binding]; other site 762376000238 dimer interface [polypeptide binding]; other site 762376000239 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 762376000240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376000241 NAD(P) binding site [chemical binding]; other site 762376000242 active site 762376000243 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376000244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376000245 dimer interface [polypeptide binding]; other site 762376000246 conserved gate region; other site 762376000247 putative PBP binding loops; other site 762376000248 ABC-ATPase subunit interface; other site 762376000249 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376000250 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762376000251 Walker A/P-loop; other site 762376000252 ATP binding site [chemical binding]; other site 762376000253 Q-loop/lid; other site 762376000254 ABC transporter signature motif; other site 762376000255 Walker B; other site 762376000256 D-loop; other site 762376000257 H-loop/switch region; other site 762376000258 NMT1/THI5 like; Region: NMT1; pfam09084 762376000259 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 762376000260 DNA topoisomerase III; Validated; Region: PRK08173 762376000261 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 762376000262 active site 762376000263 putative interdomain interaction site [polypeptide binding]; other site 762376000264 putative metal-binding site [ion binding]; other site 762376000265 putative nucleotide binding site [chemical binding]; other site 762376000266 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 762376000267 domain I; other site 762376000268 DNA binding groove [nucleotide binding] 762376000269 phosphate binding site [ion binding]; other site 762376000270 domain II; other site 762376000271 domain III; other site 762376000272 nucleotide binding site [chemical binding]; other site 762376000273 catalytic site [active] 762376000274 domain IV; other site 762376000275 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 762376000276 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 762376000277 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 762376000278 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 762376000279 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 762376000280 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 762376000281 active site 762376000282 HIGH motif; other site 762376000283 nucleotide binding site [chemical binding]; other site 762376000284 active site 762376000285 KMSKS motif; other site 762376000286 Protein of unknown function (DUF494); Region: DUF494; pfam04361 762376000287 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 762376000288 DctM-like transporters; Region: DctM; pfam06808 762376000289 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 762376000290 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 762376000291 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 762376000292 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 762376000293 dimer interface [polypeptide binding]; other site 762376000294 active site 762376000295 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376000296 substrate binding site [chemical binding]; other site 762376000297 catalytic residue [active] 762376000298 Predicted small secreted protein [Function unknown]; Region: COG5510 762376000299 CsbD-like; Region: CsbD; pfam05532 762376000300 PAS domain S-box; Region: sensory_box; TIGR00229 762376000301 PAS domain; Region: PAS; smart00091 762376000302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 762376000303 putative active site [active] 762376000304 heme pocket [chemical binding]; other site 762376000305 PAS domain S-box; Region: sensory_box; TIGR00229 762376000306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376000307 putative active site [active] 762376000308 heme pocket [chemical binding]; other site 762376000309 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376000310 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376000311 DNA binding residues [nucleotide binding] 762376000312 dimerization interface [polypeptide binding]; other site 762376000313 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376000314 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 762376000315 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376000316 inhibitor-cofactor binding pocket; inhibition site 762376000317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376000318 catalytic residue [active] 762376000319 Barstar_AU1054-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor AU1054 found in Burkholderia cenocepacia. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular...; Region: Barstar_AU1054-like; cd05140 762376000320 putative RNAase interaction site [polypeptide binding]; other site 762376000321 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376000322 dimerization interface [polypeptide binding]; other site 762376000323 putative DNA binding site [nucleotide binding]; other site 762376000324 putative Zn2+ binding site [ion binding]; other site 762376000325 Fic family protein [Function unknown]; Region: COG3177 762376000326 Fic/DOC family; Region: Fic; pfam02661 762376000327 Restriction endonuclease; Region: Mrr_cat; pfam04471 762376000328 maltose O-acetyltransferase; Provisional; Region: PRK10092 762376000329 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 762376000330 trimer interface [polypeptide binding]; other site 762376000331 active site 762376000332 substrate binding site [chemical binding]; other site 762376000333 CoA binding site [chemical binding]; other site 762376000334 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 762376000335 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 762376000336 Uncharacterized conserved protein [Function unknown]; Region: COG3339 762376000337 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 762376000338 Isochorismatase family; Region: Isochorismatase; pfam00857 762376000339 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 762376000340 catalytic triad [active] 762376000341 conserved cis-peptide bond; other site 762376000342 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 762376000343 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 762376000344 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376000345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376000346 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000347 dimerization interface [polypeptide binding]; other site 762376000348 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 762376000349 classical (c) SDRs; Region: SDR_c; cd05233 762376000350 NAD(P) binding site [chemical binding]; other site 762376000351 active site 762376000352 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376000353 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376000354 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376000355 N-terminal plug; other site 762376000356 ligand-binding site [chemical binding]; other site 762376000357 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376000358 FecR protein; Region: FecR; pfam04773 762376000359 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 762376000360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376000361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376000362 DNA binding residues [nucleotide binding] 762376000363 H+ Antiporter protein; Region: 2A0121; TIGR00900 762376000364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376000365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376000366 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376000367 putative dimerization interface [polypeptide binding]; other site 762376000368 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 762376000369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376000370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376000371 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376000372 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376000373 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376000374 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 762376000375 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376000376 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 762376000377 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376000378 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762376000379 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 762376000380 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762376000381 carboxyltransferase (CT) interaction site; other site 762376000382 biotinylation site [posttranslational modification]; other site 762376000383 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 762376000384 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 762376000385 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 762376000386 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 762376000387 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376000388 dimer interface [polypeptide binding]; other site 762376000389 active site 762376000390 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 762376000391 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 762376000392 isovaleryl-CoA dehydrogenase; Region: PLN02519 762376000393 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 762376000394 substrate binding site [chemical binding]; other site 762376000395 FAD binding site [chemical binding]; other site 762376000396 catalytic base [active] 762376000397 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376000398 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 762376000399 metal binding site [ion binding]; metal-binding site 762376000400 putative dimer interface [polypeptide binding]; other site 762376000401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376000402 hypothetical protein; Provisional; Region: PRK02237 762376000403 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 762376000404 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 762376000405 DNA binding residues [nucleotide binding] 762376000406 putative dimer interface [polypeptide binding]; other site 762376000407 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 762376000408 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376000409 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 762376000410 putative FMN binding site [chemical binding]; other site 762376000411 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 762376000412 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762376000413 homodimer interface [polypeptide binding]; other site 762376000414 substrate-cofactor binding pocket; other site 762376000415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376000416 catalytic residue [active] 762376000417 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-1; cd12808 762376000418 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376000419 catalytic site [active] 762376000420 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376000421 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376000422 putative ligand binding site [chemical binding]; other site 762376000423 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 762376000424 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 762376000425 catalytic residues [active] 762376000426 hinge region; other site 762376000427 alpha helical domain; other site 762376000428 Sporulation related domain; Region: SPOR; pfam05036 762376000429 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 762376000430 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 762376000431 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 762376000432 active site 762376000433 HIGH motif; other site 762376000434 KMSK motif region; other site 762376000435 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762376000436 tRNA binding surface [nucleotide binding]; other site 762376000437 anticodon binding site; other site 762376000438 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 762376000439 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 762376000440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376000441 dimer interface [polypeptide binding]; other site 762376000442 conserved gate region; other site 762376000443 putative PBP binding loops; other site 762376000444 ABC-ATPase subunit interface; other site 762376000445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376000446 dimer interface [polypeptide binding]; other site 762376000447 conserved gate region; other site 762376000448 putative PBP binding loops; other site 762376000449 ABC-ATPase subunit interface; other site 762376000450 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762376000451 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762376000452 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 762376000453 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 762376000454 Walker A/P-loop; other site 762376000455 ATP binding site [chemical binding]; other site 762376000456 Q-loop/lid; other site 762376000457 ABC transporter signature motif; other site 762376000458 Walker B; other site 762376000459 D-loop; other site 762376000460 H-loop/switch region; other site 762376000461 TOBE domain; Region: TOBE_2; pfam08402 762376000462 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 762376000463 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376000464 active site 762376000465 metal binding site [ion binding]; metal-binding site 762376000466 hexamer interface [polypeptide binding]; other site 762376000467 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762376000468 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762376000469 DNA binding site [nucleotide binding] 762376000470 domain linker motif; other site 762376000471 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 762376000472 putative dimerization interface [polypeptide binding]; other site 762376000473 putative ligand binding site [chemical binding]; other site 762376000474 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376000475 Amidase; Region: Amidase; pfam01425 762376000476 2-isopropylmalate synthase; Validated; Region: PRK03739 762376000477 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 762376000478 active site 762376000479 catalytic residues [active] 762376000480 metal binding site [ion binding]; metal-binding site 762376000481 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 762376000482 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 762376000483 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 762376000484 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 762376000485 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 762376000486 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 762376000487 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376000488 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000489 dimerization interface [polypeptide binding]; other site 762376000490 EamA-like transporter family; Region: EamA; pfam00892 762376000491 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 762376000492 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 762376000493 heme binding site [chemical binding]; other site 762376000494 ferroxidase pore; other site 762376000495 ferroxidase diiron center [ion binding]; other site 762376000496 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 762376000497 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 762376000498 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 762376000499 G1 box; other site 762376000500 putative GEF interaction site [polypeptide binding]; other site 762376000501 GTP/Mg2+ binding site [chemical binding]; other site 762376000502 Switch I region; other site 762376000503 G2 box; other site 762376000504 G3 box; other site 762376000505 Switch II region; other site 762376000506 G4 box; other site 762376000507 G5 box; other site 762376000508 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 762376000509 LysE type translocator; Region: LysE; cl00565 762376000510 helicase 45; Provisional; Region: PTZ00424 762376000511 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 762376000512 ATP binding site [chemical binding]; other site 762376000513 Mg++ binding site [ion binding]; other site 762376000514 motif III; other site 762376000515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376000516 nucleotide binding region [chemical binding]; other site 762376000517 ATP-binding site [chemical binding]; other site 762376000518 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 762376000519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 762376000520 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 762376000521 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 762376000522 active site 762376000523 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376000524 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376000525 Walker A/P-loop; other site 762376000526 ATP binding site [chemical binding]; other site 762376000527 Q-loop/lid; other site 762376000528 ABC transporter signature motif; other site 762376000529 Walker B; other site 762376000530 D-loop; other site 762376000531 H-loop/switch region; other site 762376000532 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376000533 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376000534 Walker A/P-loop; other site 762376000535 ATP binding site [chemical binding]; other site 762376000536 Q-loop/lid; other site 762376000537 ABC transporter signature motif; other site 762376000538 Walker B; other site 762376000539 D-loop; other site 762376000540 H-loop/switch region; other site 762376000541 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376000542 dipeptide transporter; Provisional; Region: PRK10913 762376000543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376000544 dimer interface [polypeptide binding]; other site 762376000545 conserved gate region; other site 762376000546 putative PBP binding loops; other site 762376000547 ABC-ATPase subunit interface; other site 762376000548 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376000549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376000550 dimer interface [polypeptide binding]; other site 762376000551 conserved gate region; other site 762376000552 putative PBP binding loops; other site 762376000553 ABC-ATPase subunit interface; other site 762376000554 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376000555 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376000556 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 762376000557 G1 box; other site 762376000558 GTP/Mg2+ binding site [chemical binding]; other site 762376000559 G2 box; other site 762376000560 Switch I region; other site 762376000561 G3 box; other site 762376000562 Switch II region; other site 762376000563 G4 box; other site 762376000564 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 762376000565 G5 box; other site 762376000566 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 762376000567 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376000568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376000569 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 762376000570 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762376000571 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376000572 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376000573 catalytic residue [active] 762376000574 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 762376000575 homotrimer interaction site [polypeptide binding]; other site 762376000576 putative active site [active] 762376000577 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376000578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376000579 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376000580 dimerization interface [polypeptide binding]; other site 762376000581 substrate binding pocket [chemical binding]; other site 762376000582 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 762376000583 stringent starvation protein A; Provisional; Region: sspA; PRK09481 762376000584 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 762376000585 C-terminal domain interface [polypeptide binding]; other site 762376000586 putative GSH binding site (G-site) [chemical binding]; other site 762376000587 dimer interface [polypeptide binding]; other site 762376000588 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 762376000589 dimer interface [polypeptide binding]; other site 762376000590 N-terminal domain interface [polypeptide binding]; other site 762376000591 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 762376000592 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 762376000593 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 762376000594 Qi binding site; other site 762376000595 intrachain domain interface; other site 762376000596 interchain domain interface [polypeptide binding]; other site 762376000597 heme bH binding site [chemical binding]; other site 762376000598 heme bL binding site [chemical binding]; other site 762376000599 Qo binding site; other site 762376000600 interchain domain interface [polypeptide binding]; other site 762376000601 intrachain domain interface; other site 762376000602 Qi binding site; other site 762376000603 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 762376000604 Qo binding site; other site 762376000605 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 762376000606 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 762376000607 [2Fe-2S] cluster binding site [ion binding]; other site 762376000608 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 762376000609 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 762376000610 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 762376000611 intersubunit interface [polypeptide binding]; other site 762376000612 active site 762376000613 Zn2+ binding site [ion binding]; other site 762376000614 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376000615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376000616 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376000617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000618 putative substrate translocation pore; other site 762376000619 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376000620 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376000621 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 762376000622 N-terminal domain interface [polypeptide binding]; other site 762376000623 dimer interface [polypeptide binding]; other site 762376000624 substrate binding pocket (H-site) [chemical binding]; other site 762376000625 Uncharacterized conserved protein [Function unknown]; Region: COG0327 762376000626 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 762376000627 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762376000628 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762376000629 protein binding site [polypeptide binding]; other site 762376000630 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 762376000631 sec-independent translocase; Provisional; Region: tatB; PRK00404 762376000632 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 762376000633 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 762376000634 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 762376000635 nucleotide binding site/active site [active] 762376000636 HIT family signature motif; other site 762376000637 catalytic residue [active] 762376000638 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 762376000639 metal binding site [ion binding]; metal-binding site 762376000640 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 762376000641 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 762376000642 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 762376000643 substrate binding site [chemical binding]; other site 762376000644 glutamase interaction surface [polypeptide binding]; other site 762376000645 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 762376000646 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 762376000647 catalytic residues [active] 762376000648 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 762376000649 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 762376000650 putative active site [active] 762376000651 oxyanion strand; other site 762376000652 catalytic triad [active] 762376000653 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 762376000654 putative active site pocket [active] 762376000655 4-fold oligomerization interface [polypeptide binding]; other site 762376000656 metal binding residues [ion binding]; metal-binding site 762376000657 3-fold/trimer interface [polypeptide binding]; other site 762376000658 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 762376000659 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376000660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376000661 homodimer interface [polypeptide binding]; other site 762376000662 catalytic residue [active] 762376000663 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 762376000664 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 762376000665 NAD binding site [chemical binding]; other site 762376000666 dimerization interface [polypeptide binding]; other site 762376000667 product binding site; other site 762376000668 substrate binding site [chemical binding]; other site 762376000669 zinc binding site [ion binding]; other site 762376000670 catalytic residues [active] 762376000671 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 762376000672 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 762376000673 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 762376000674 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 762376000675 hinge; other site 762376000676 active site 762376000677 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 762376000678 ABC-2 type transporter; Region: ABC2_membrane; cl17235 762376000679 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 762376000680 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 762376000681 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 762376000682 Walker A/P-loop; other site 762376000683 ATP binding site [chemical binding]; other site 762376000684 Q-loop/lid; other site 762376000685 ABC transporter signature motif; other site 762376000686 Walker B; other site 762376000687 D-loop; other site 762376000688 H-loop/switch region; other site 762376000689 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 762376000690 VacJ like lipoprotein; Region: VacJ; cl01073 762376000691 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 762376000692 mce related protein; Region: MCE; pfam02470 762376000693 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 762376000694 Permease; Region: Permease; pfam02405 762376000695 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 762376000696 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 762376000697 Walker A/P-loop; other site 762376000698 ATP binding site [chemical binding]; other site 762376000699 Q-loop/lid; other site 762376000700 ABC transporter signature motif; other site 762376000701 Walker B; other site 762376000702 D-loop; other site 762376000703 H-loop/switch region; other site 762376000704 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 762376000705 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 762376000706 FMN binding site [chemical binding]; other site 762376000707 substrate binding site [chemical binding]; other site 762376000708 putative catalytic residue [active] 762376000709 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376000710 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 762376000711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376000712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376000713 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 762376000714 putative dimerization interface [polypeptide binding]; other site 762376000715 OmpW family; Region: OmpW; cl17427 762376000716 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 762376000717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762376000718 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 762376000719 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 762376000720 active site 762376000721 dimer interface [polypeptide binding]; other site 762376000722 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 762376000723 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 762376000724 active site 762376000725 FMN binding site [chemical binding]; other site 762376000726 substrate binding site [chemical binding]; other site 762376000727 3Fe-4S cluster binding site [ion binding]; other site 762376000728 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 762376000729 domain interface; other site 762376000730 S-formylglutathione hydrolase; Region: PLN02442 762376000731 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 762376000732 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 762376000733 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376000734 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376000735 DNA binding residues [nucleotide binding] 762376000736 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 762376000737 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376000738 active site 762376000739 metal binding site [ion binding]; metal-binding site 762376000740 hexamer interface [polypeptide binding]; other site 762376000741 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762376000742 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 762376000743 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376000744 flexible hinge region; other site 762376000745 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762376000746 nudix motif; other site 762376000747 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 762376000748 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 762376000749 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 762376000750 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762376000751 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 762376000752 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 762376000753 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 762376000754 Subunit I/III interface [polypeptide binding]; other site 762376000755 D-pathway; other site 762376000756 Subunit I/VIIc interface [polypeptide binding]; other site 762376000757 Subunit I/IV interface [polypeptide binding]; other site 762376000758 Subunit I/II interface [polypeptide binding]; other site 762376000759 Low-spin heme (heme a) binding site [chemical binding]; other site 762376000760 Subunit I/VIIa interface [polypeptide binding]; other site 762376000761 Subunit I/VIa interface [polypeptide binding]; other site 762376000762 Dimer interface; other site 762376000763 Putative water exit pathway; other site 762376000764 Binuclear center (heme a3/CuB) [ion binding]; other site 762376000765 K-pathway; other site 762376000766 Subunit I/Vb interface [polypeptide binding]; other site 762376000767 Putative proton exit pathway; other site 762376000768 Subunit I/VIb interface; other site 762376000769 Subunit I/VIc interface [polypeptide binding]; other site 762376000770 Electron transfer pathway; other site 762376000771 Subunit I/VIIIb interface [polypeptide binding]; other site 762376000772 Subunit I/VIIb interface [polypeptide binding]; other site 762376000773 Coiled-coil domain-containing protein 56; Region: Coiled-coil_56; pfam09813 762376000774 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 762376000775 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 762376000776 Subunit III/VIIa interface [polypeptide binding]; other site 762376000777 Phospholipid binding site [chemical binding]; other site 762376000778 Subunit I/III interface [polypeptide binding]; other site 762376000779 Subunit III/VIb interface [polypeptide binding]; other site 762376000780 Subunit III/VIa interface; other site 762376000781 Subunit III/Vb interface [polypeptide binding]; other site 762376000782 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 762376000783 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 762376000784 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376000785 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 762376000786 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 762376000787 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 762376000788 UbiA prenyltransferase family; Region: UbiA; pfam01040 762376000789 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 762376000790 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 762376000791 Cu(I) binding site [ion binding]; other site 762376000792 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 762376000793 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 762376000794 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 762376000795 Substrate binding site; other site 762376000796 Mg++ binding site; other site 762376000797 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 762376000798 active site 762376000799 substrate binding site [chemical binding]; other site 762376000800 CoA binding site [chemical binding]; other site 762376000801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000802 putative substrate translocation pore; other site 762376000803 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 762376000804 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 762376000805 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 762376000806 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376000807 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376000808 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376000809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376000810 putative DNA binding site [nucleotide binding]; other site 762376000811 putative Zn2+ binding site [ion binding]; other site 762376000812 AsnC family; Region: AsnC_trans_reg; pfam01037 762376000813 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 762376000814 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 762376000815 glutaminase active site [active] 762376000816 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 762376000817 dimer interface [polypeptide binding]; other site 762376000818 active site 762376000819 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 762376000820 dimer interface [polypeptide binding]; other site 762376000821 active site 762376000822 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 762376000823 TrkA-N domain; Region: TrkA_N; pfam02254 762376000824 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 762376000825 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 762376000826 Vi polysaccharide biosynthesis protein TviD; Provisional; Region: PRK15180 762376000827 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 762376000828 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15179 762376000829 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 762376000830 putative ADP-binding pocket [chemical binding]; other site 762376000831 Vi polysaccharide export protein VexA; Provisional; Region: PRK15175 762376000832 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 762376000833 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 762376000834 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 762376000835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376000836 Q-loop/lid; other site 762376000837 ABC transporter signature motif; other site 762376000838 Walker B; other site 762376000839 D-loop; other site 762376000840 H-loop/switch region; other site 762376000841 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 762376000842 Vi polysaccharide export protein VexE; Provisional; Region: PRK15174 762376000843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762376000844 TPR motif; other site 762376000845 binding surface 762376000846 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 762376000847 putative acyl-acceptor binding pocket; other site 762376000848 Amb_all domain; Region: Amb_all; smart00656 762376000849 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376000850 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376000851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000852 OsmC-like protein; Region: OsmC; cl00767 762376000853 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376000854 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376000855 ligand binding site [chemical binding]; other site 762376000856 flexible hinge region; other site 762376000857 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 762376000858 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376000859 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376000860 putative ligand binding site [chemical binding]; other site 762376000861 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 762376000862 short chain dehydrogenase; Provisional; Region: PRK12829 762376000863 classical (c) SDRs; Region: SDR_c; cd05233 762376000864 NAD(P) binding site [chemical binding]; other site 762376000865 active site 762376000866 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 762376000867 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376000868 Ligand Binding Site [chemical binding]; other site 762376000869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376000870 S-adenosylmethionine binding site [chemical binding]; other site 762376000871 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376000872 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376000873 active site 762376000874 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 762376000875 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 762376000876 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376000877 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376000878 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376000879 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376000880 CoA binding domain; Region: CoA_binding_2; pfam13380 762376000881 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762376000882 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762376000883 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376000884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376000885 NAD(P) binding site [chemical binding]; other site 762376000886 active site 762376000887 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376000888 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376000889 active site 762376000890 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376000891 active site 2 [active] 762376000892 active site 1 [active] 762376000893 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 762376000894 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 762376000895 active site 762376000896 oxalacetate binding site [chemical binding]; other site 762376000897 citrylCoA binding site [chemical binding]; other site 762376000898 coenzyme A binding site [chemical binding]; other site 762376000899 catalytic triad [active] 762376000900 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376000901 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376000902 CHAT domain; Region: CHAT; cl17868 762376000903 PAS fold; Region: PAS_4; pfam08448 762376000904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376000905 putative active site [active] 762376000906 heme pocket [chemical binding]; other site 762376000907 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 762376000908 active site 762376000909 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762376000910 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762376000911 active site 762376000912 catalytic tetrad [active] 762376000913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376000914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376000915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376000916 dimerization interface [polypeptide binding]; other site 762376000917 ornithine cyclodeaminase; Validated; Region: PRK06141 762376000918 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 762376000919 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 762376000920 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376000921 tetramer interface [polypeptide binding]; other site 762376000922 active site 762376000923 catalytic triad [active] 762376000924 dimer interface [polypeptide binding]; other site 762376000925 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376000926 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 762376000927 AsnC family; Region: AsnC_trans_reg; pfam01037 762376000928 ornithine cyclodeaminase; Validated; Region: PRK07589 762376000929 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 762376000930 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 762376000931 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762376000932 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 762376000933 G1 box; other site 762376000934 Walker A motif; other site 762376000935 GTP/Mg2+ binding site [chemical binding]; other site 762376000936 G2 box; other site 762376000937 G3 box; other site 762376000938 Switch II region; other site 762376000939 G4 box; other site 762376000940 G5 box; other site 762376000941 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 762376000942 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 762376000943 oligomerization interface [polypeptide binding]; other site 762376000944 active site 762376000945 metal binding site [ion binding]; metal-binding site 762376000946 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 762376000947 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 762376000948 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376000949 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376000950 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 762376000951 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 762376000952 active site 762376000953 metal binding site [ion binding]; metal-binding site 762376000954 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762376000955 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 762376000956 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 762376000957 substrate binding site [chemical binding]; other site 762376000958 catalytic Zn binding site [ion binding]; other site 762376000959 NAD binding site [chemical binding]; other site 762376000960 structural Zn binding site [ion binding]; other site 762376000961 dimer interface [polypeptide binding]; other site 762376000962 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 762376000963 putative metal binding site [ion binding]; other site 762376000964 putative homodimer interface [polypeptide binding]; other site 762376000965 putative homotetramer interface [polypeptide binding]; other site 762376000966 putative homodimer-homodimer interface [polypeptide binding]; other site 762376000967 putative allosteric switch controlling residues; other site 762376000968 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 762376000969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376000970 DNA-binding site [nucleotide binding]; DNA binding site 762376000971 UTRA domain; Region: UTRA; pfam07702 762376000972 HutD; Region: HutD; pfam05962 762376000973 urocanate hydratase; Provisional; Region: PRK05414 762376000974 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 762376000975 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 762376000976 Na binding site [ion binding]; other site 762376000977 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 762376000978 active sites [active] 762376000979 tetramer interface [polypeptide binding]; other site 762376000980 imidazolonepropionase; Validated; Region: PRK09356 762376000981 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 762376000982 active site 762376000983 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 762376000984 active site 762376000985 catalytic triad [active] 762376000986 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376000987 dimer interface [polypeptide binding]; other site 762376000988 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376000989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000990 putative substrate translocation pore; other site 762376000991 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376000992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376000993 putative substrate translocation pore; other site 762376000994 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 762376000995 sulfite oxidase; Provisional; Region: PLN00177 762376000996 Moco binding site; other site 762376000997 metal coordination site [ion binding]; other site 762376000998 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 762376000999 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 762376001000 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 762376001001 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376001002 catalytic loop [active] 762376001003 iron binding site [ion binding]; other site 762376001004 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 762376001005 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376001006 catalytic loop [active] 762376001007 iron binding site [ion binding]; other site 762376001008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001009 DNA-binding site [nucleotide binding]; DNA binding site 762376001010 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376001011 FCD domain; Region: FCD; pfam07729 762376001012 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376001013 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 762376001014 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376001015 NAD(P) binding site [chemical binding]; other site 762376001016 catalytic residues [active] 762376001017 Domain of unknown function (DUF336); Region: DUF336; pfam03928 762376001018 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 762376001019 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376001020 catalytic loop [active] 762376001021 iron binding site [ion binding]; other site 762376001022 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 762376001023 FAD binding pocket [chemical binding]; other site 762376001024 FAD binding motif [chemical binding]; other site 762376001025 phosphate binding motif [ion binding]; other site 762376001026 beta-alpha-beta structure motif; other site 762376001027 NAD binding pocket [chemical binding]; other site 762376001028 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376001029 Ligand Binding Site [chemical binding]; other site 762376001030 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 762376001031 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762376001032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 762376001033 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376001034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376001035 Walker A/P-loop; other site 762376001036 ATP binding site [chemical binding]; other site 762376001037 Q-loop/lid; other site 762376001038 ABC transporter signature motif; other site 762376001039 Walker B; other site 762376001040 D-loop; other site 762376001041 H-loop/switch region; other site 762376001042 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 762376001043 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 762376001044 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 762376001045 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 762376001046 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 762376001047 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 762376001048 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 762376001049 NodB motif; other site 762376001050 active site 762376001051 catalytic site [active] 762376001052 metal binding site [ion binding]; metal-binding site 762376001053 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 762376001054 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 762376001055 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 762376001056 Uncharacterized conserved protein [Function unknown]; Region: COG5361 762376001057 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 762376001058 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762376001059 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762376001060 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762376001061 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762376001062 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 762376001063 molybdopterin cofactor binding site; other site 762376001064 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 762376001065 4Fe-4S binding domain; Region: Fer4; cl02805 762376001066 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 762376001067 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 762376001068 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 762376001069 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 762376001070 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 762376001071 selenocysteine synthase; Provisional; Region: PRK04311 762376001072 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 762376001073 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 762376001074 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376001075 catalytic residue [active] 762376001076 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 762376001077 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 762376001078 G1 box; other site 762376001079 putative GEF interaction site [polypeptide binding]; other site 762376001080 GTP/Mg2+ binding site [chemical binding]; other site 762376001081 Switch I region; other site 762376001082 G2 box; other site 762376001083 G3 box; other site 762376001084 Switch II region; other site 762376001085 G4 box; other site 762376001086 G5 box; other site 762376001087 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 762376001088 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 762376001089 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 762376001090 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 762376001091 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 762376001092 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762376001093 catalytic residues [active] 762376001094 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 762376001095 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 762376001096 selenophosphate synthetase; Provisional; Region: PRK00943 762376001097 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 762376001098 dimerization interface [polypeptide binding]; other site 762376001099 putative ATP binding site [chemical binding]; other site 762376001100 Sulfatase; Region: Sulfatase; cl17466 762376001101 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 762376001102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376001103 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001104 dimerization interface [polypeptide binding]; other site 762376001105 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 762376001106 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 762376001107 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 762376001108 putative catalytic residue [active] 762376001109 Protein of unknown function (DUF779); Region: DUF779; pfam05610 762376001110 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 762376001111 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376001112 NAD(P) binding site [chemical binding]; other site 762376001113 catalytic residues [active] 762376001114 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 762376001115 GAF domain; Region: GAF; pfam01590 762376001116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376001117 Walker A motif; other site 762376001118 ATP binding site [chemical binding]; other site 762376001119 Walker B motif; other site 762376001120 arginine finger; other site 762376001121 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762376001122 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 762376001123 active site 762376001124 ribulose/triose binding site [chemical binding]; other site 762376001125 phosphate binding site [ion binding]; other site 762376001126 substrate (anthranilate) binding pocket [chemical binding]; other site 762376001127 product (indole) binding pocket [chemical binding]; other site 762376001128 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 762376001129 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 762376001130 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 762376001131 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 762376001132 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 762376001133 glutamine binding [chemical binding]; other site 762376001134 catalytic triad [active] 762376001135 anthranilate synthase component I; Provisional; Region: PRK13565 762376001136 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 762376001137 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 762376001138 phosphoglycolate phosphatase; Provisional; Region: PRK13222 762376001139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376001140 motif II; other site 762376001141 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 762376001142 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 762376001143 substrate binding site [chemical binding]; other site 762376001144 hexamer interface [polypeptide binding]; other site 762376001145 metal binding site [ion binding]; metal-binding site 762376001146 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 762376001147 MltA specific insert domain; Region: MltA; smart00925 762376001148 3D domain; Region: 3D; pfam06725 762376001149 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 762376001150 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 762376001151 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 762376001152 dimerization domain [polypeptide binding]; other site 762376001153 dimer interface [polypeptide binding]; other site 762376001154 catalytic residues [active] 762376001155 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762376001156 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 762376001157 dimerization interface [polypeptide binding]; other site 762376001158 NAD binding site [chemical binding]; other site 762376001159 ligand binding site [chemical binding]; other site 762376001160 catalytic site [active] 762376001161 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 762376001162 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 762376001163 Ligand Binding Site [chemical binding]; other site 762376001164 TIGR00269 family protein; Region: TIGR00269 762376001165 Dihydroneopterin aldolase; Region: FolB; pfam02152 762376001166 active site 762376001167 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 762376001168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376001169 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 762376001170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376001172 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001173 dimerization interface [polypeptide binding]; other site 762376001174 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376001175 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 762376001176 putative ligand binding site [chemical binding]; other site 762376001177 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376001178 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376001179 TM-ABC transporter signature motif; other site 762376001180 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376001181 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376001182 TM-ABC transporter signature motif; other site 762376001183 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 762376001184 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376001185 Walker A/P-loop; other site 762376001186 ATP binding site [chemical binding]; other site 762376001187 Q-loop/lid; other site 762376001188 ABC transporter signature motif; other site 762376001189 Walker B; other site 762376001190 D-loop; other site 762376001191 H-loop/switch region; other site 762376001192 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 762376001193 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376001194 Walker A/P-loop; other site 762376001195 ATP binding site [chemical binding]; other site 762376001196 Q-loop/lid; other site 762376001197 ABC transporter signature motif; other site 762376001198 Walker B; other site 762376001199 D-loop; other site 762376001200 H-loop/switch region; other site 762376001201 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 762376001202 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 762376001203 multimer interface [polypeptide binding]; other site 762376001204 active site 762376001205 catalytic triad [active] 762376001206 dimer interface [polypeptide binding]; other site 762376001207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376001208 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762376001209 Walker A motif; other site 762376001210 ATP binding site [chemical binding]; other site 762376001211 Walker B motif; other site 762376001212 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 762376001213 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 762376001214 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 762376001215 metal ion-dependent adhesion site (MIDAS); other site 762376001216 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376001217 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 762376001218 ligand binding site [chemical binding]; other site 762376001219 regulator interaction site; other site 762376001220 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 762376001221 ANTAR domain; Region: ANTAR; pfam03861 762376001222 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376001223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376001225 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376001226 dimerization interface [polypeptide binding]; other site 762376001227 substrate binding pocket [chemical binding]; other site 762376001228 Transposase, Mutator family; Region: Transposase_mut; pfam00872 762376001229 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 762376001230 MULE transposase domain; Region: MULE; pfam10551 762376001231 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 762376001232 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 762376001233 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 762376001234 protein binding site [polypeptide binding]; other site 762376001235 enoyl-CoA hydratase; Provisional; Region: PRK05862 762376001236 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376001237 substrate binding site [chemical binding]; other site 762376001238 oxyanion hole (OAH) forming residues; other site 762376001239 trimer interface [polypeptide binding]; other site 762376001240 Uncharacterized conserved protein [Function unknown]; Region: COG5361 762376001241 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 762376001242 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 762376001243 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 762376001244 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 762376001245 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 762376001246 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 762376001247 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 762376001248 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 762376001249 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 762376001250 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 762376001251 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762376001252 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 762376001253 beta subunit interaction interface [polypeptide binding]; other site 762376001254 Walker A motif; other site 762376001255 ATP binding site [chemical binding]; other site 762376001256 Walker B motif; other site 762376001257 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762376001258 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 762376001259 core domain interface [polypeptide binding]; other site 762376001260 delta subunit interface [polypeptide binding]; other site 762376001261 epsilon subunit interface [polypeptide binding]; other site 762376001262 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 762376001263 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762376001264 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 762376001265 alpha subunit interaction interface [polypeptide binding]; other site 762376001266 Walker A motif; other site 762376001267 ATP binding site [chemical binding]; other site 762376001268 Walker B motif; other site 762376001269 inhibitor binding site; inhibition site 762376001270 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762376001271 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 762376001272 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 762376001273 gamma subunit interface [polypeptide binding]; other site 762376001274 epsilon subunit interface [polypeptide binding]; other site 762376001275 LBP interface [polypeptide binding]; other site 762376001276 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 762376001277 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 762376001278 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 762376001279 substrate binding site [chemical binding]; other site 762376001280 active site 762376001281 primosome assembly protein PriA; Validated; Region: PRK05580 762376001282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376001283 ATP binding site [chemical binding]; other site 762376001284 putative Mg++ binding site [ion binding]; other site 762376001285 helicase superfamily c-terminal domain; Region: HELICc; smart00490 762376001286 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 762376001287 Part of AAA domain; Region: AAA_19; pfam13245 762376001288 Family description; Region: UvrD_C_2; pfam13538 762376001289 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 762376001290 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 762376001291 putative active site [active] 762376001292 putative dimer interface [polypeptide binding]; other site 762376001293 Pleckstrin homology-like domain; Region: PH-like; cl17171 762376001294 Replication initiator protein A; Region: RPA; cl17860 762376001295 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 762376001296 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 762376001297 putative trimer interface [polypeptide binding]; other site 762376001298 putative CoA binding site [chemical binding]; other site 762376001299 Autotransporter beta-domain; Region: Autotransporter; pfam03797 762376001300 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 762376001301 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 762376001302 metal binding site [ion binding]; metal-binding site 762376001303 dimer interface [polypeptide binding]; other site 762376001304 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762376001305 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 762376001306 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376001307 Walker A/P-loop; other site 762376001308 ATP binding site [chemical binding]; other site 762376001309 Q-loop/lid; other site 762376001310 ABC transporter signature motif; other site 762376001311 Walker B; other site 762376001312 D-loop; other site 762376001313 H-loop/switch region; other site 762376001314 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 762376001315 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376001316 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376001317 Walker A/P-loop; other site 762376001318 ATP binding site [chemical binding]; other site 762376001319 Q-loop/lid; other site 762376001320 ABC transporter signature motif; other site 762376001321 Walker B; other site 762376001322 D-loop; other site 762376001323 H-loop/switch region; other site 762376001324 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376001325 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376001326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376001327 dimer interface [polypeptide binding]; other site 762376001328 conserved gate region; other site 762376001329 putative PBP binding loops; other site 762376001330 ABC-ATPase subunit interface; other site 762376001331 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376001332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376001333 dimer interface [polypeptide binding]; other site 762376001334 conserved gate region; other site 762376001335 putative PBP binding loops; other site 762376001336 ABC-ATPase subunit interface; other site 762376001337 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376001338 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376001339 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 762376001340 active site 762376001341 Zn binding site [ion binding]; other site 762376001342 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376001344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001345 dimerization interface [polypeptide binding]; other site 762376001346 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376001347 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376001348 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 762376001349 putative ATP binding site [chemical binding]; other site 762376001350 putative substrate binding site [chemical binding]; other site 762376001351 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376001352 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376001353 substrate binding site [chemical binding]; other site 762376001354 oxyanion hole (OAH) forming residues; other site 762376001355 trimer interface [polypeptide binding]; other site 762376001356 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 762376001357 enoyl-CoA hydratase; Provisional; Region: PRK06688 762376001358 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376001359 substrate binding site [chemical binding]; other site 762376001360 oxyanion hole (OAH) forming residues; other site 762376001361 trimer interface [polypeptide binding]; other site 762376001362 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 762376001363 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 762376001364 FMN binding site [chemical binding]; other site 762376001365 substrate binding site [chemical binding]; other site 762376001366 putative catalytic residue [active] 762376001367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376001368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376001369 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376001370 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376001371 active site 762376001372 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376001373 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376001374 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 762376001375 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376001376 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376001377 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376001378 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376001379 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 762376001380 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376001381 active site 762376001382 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 762376001383 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762376001384 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 762376001385 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376001386 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376001387 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376001388 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376001390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001391 dimerization interface [polypeptide binding]; other site 762376001392 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 762376001393 classical (c) SDRs; Region: SDR_c; cd05233 762376001394 NAD(P) binding site [chemical binding]; other site 762376001395 active site 762376001396 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 762376001397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001398 NAD(P) binding site [chemical binding]; other site 762376001399 active site 762376001400 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762376001401 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762376001402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376001403 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762376001404 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 762376001405 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 762376001406 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376001407 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376001408 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376001409 N-terminal plug; other site 762376001410 ligand-binding site [chemical binding]; other site 762376001411 fec operon regulator FecR; Reviewed; Region: PRK09774 762376001412 FecR protein; Region: FecR; pfam04773 762376001413 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376001414 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376001415 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376001416 DNA binding residues [nucleotide binding] 762376001417 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376001418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001419 DNA-binding site [nucleotide binding]; DNA binding site 762376001420 UTRA domain; Region: UTRA; pfam07702 762376001421 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 762376001422 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 762376001423 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 762376001424 nucleotide binding site [chemical binding]; other site 762376001425 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 762376001426 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 762376001427 ligand binding site [chemical binding]; other site 762376001428 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 762376001429 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 762376001430 Walker A/P-loop; other site 762376001431 ATP binding site [chemical binding]; other site 762376001432 Q-loop/lid; other site 762376001433 ABC transporter signature motif; other site 762376001434 Walker B; other site 762376001435 D-loop; other site 762376001436 H-loop/switch region; other site 762376001437 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 762376001438 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376001439 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 762376001440 TM-ABC transporter signature motif; other site 762376001441 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762376001442 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762376001443 active site 762376001444 catalytic tetrad [active] 762376001445 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 762376001446 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 762376001447 putative active site; other site 762376001448 catalytic residue [active] 762376001449 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 762376001450 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376001451 catalytic loop [active] 762376001452 iron binding site [ion binding]; other site 762376001453 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376001454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376001455 dimer interface [polypeptide binding]; other site 762376001456 phosphorylation site [posttranslational modification] 762376001457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376001458 ATP binding site [chemical binding]; other site 762376001459 Mg2+ binding site [ion binding]; other site 762376001460 G-X-G motif; other site 762376001461 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 762376001462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376001463 active site 762376001464 phosphorylation site [posttranslational modification] 762376001465 intermolecular recognition site; other site 762376001466 dimerization interface [polypeptide binding]; other site 762376001467 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376001468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376001469 active site 762376001470 phosphorylation site [posttranslational modification] 762376001471 intermolecular recognition site; other site 762376001472 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376001473 DNA binding residues [nucleotide binding] 762376001474 dimerization interface [polypeptide binding]; other site 762376001475 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 762376001476 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 762376001477 putative active site [active] 762376001478 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762376001479 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 762376001480 Walker A/P-loop; other site 762376001481 ATP binding site [chemical binding]; other site 762376001482 Q-loop/lid; other site 762376001483 ABC transporter signature motif; other site 762376001484 Walker B; other site 762376001485 D-loop; other site 762376001486 H-loop/switch region; other site 762376001487 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 762376001488 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376001489 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376001490 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 762376001491 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 762376001492 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 762376001493 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 762376001494 putative DNA binding site [nucleotide binding]; other site 762376001495 putative homodimer interface [polypeptide binding]; other site 762376001496 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 762376001497 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 762376001498 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 762376001499 active site 762376001500 DNA binding site [nucleotide binding] 762376001501 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 762376001502 DNA binding site [nucleotide binding] 762376001503 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 762376001504 nucleotide binding site [chemical binding]; other site 762376001505 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762376001506 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762376001507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001508 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762376001509 NAD(P) binding site [chemical binding]; other site 762376001510 active site 762376001511 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 762376001512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376001514 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376001515 putative effector binding pocket; other site 762376001516 dimerization interface [polypeptide binding]; other site 762376001517 Cupin domain; Region: Cupin_2; pfam07883 762376001518 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 762376001519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376001520 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376001521 DNA binding residues [nucleotide binding] 762376001522 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 762376001523 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762376001524 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762376001525 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 762376001526 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762376001527 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762376001528 short chain dehydrogenase; Provisional; Region: PRK06500 762376001529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001530 NAD(P) binding site [chemical binding]; other site 762376001531 active site 762376001532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376001534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376001535 dimerization interface [polypeptide binding]; other site 762376001536 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376001537 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 762376001538 Cupin domain; Region: Cupin_2; pfam07883 762376001539 Cupin domain; Region: Cupin_2; pfam07883 762376001540 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376001541 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376001542 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376001543 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 762376001544 putative ligand binding site [chemical binding]; other site 762376001545 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376001546 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376001547 TM-ABC transporter signature motif; other site 762376001548 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376001549 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376001550 TM-ABC transporter signature motif; other site 762376001551 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376001552 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376001553 Walker A/P-loop; other site 762376001554 ATP binding site [chemical binding]; other site 762376001555 Q-loop/lid; other site 762376001556 ABC transporter signature motif; other site 762376001557 Walker B; other site 762376001558 D-loop; other site 762376001559 H-loop/switch region; other site 762376001560 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376001561 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376001562 Walker A/P-loop; other site 762376001563 ATP binding site [chemical binding]; other site 762376001564 Q-loop/lid; other site 762376001565 ABC transporter signature motif; other site 762376001566 Walker B; other site 762376001567 D-loop; other site 762376001568 H-loop/switch region; other site 762376001569 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376001570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001571 DNA-binding site [nucleotide binding]; DNA binding site 762376001572 FCD domain; Region: FCD; pfam07729 762376001573 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 762376001574 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 762376001575 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376001577 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376001578 dimerization interface [polypeptide binding]; other site 762376001579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376001580 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 762376001581 active site 762376001582 Zn binding site [ion binding]; other site 762376001583 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 762376001584 glutamate--cysteine ligase; Provisional; Region: PRK02107 762376001585 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 762376001586 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762376001587 Serine hydrolase; Region: Ser_hydrolase; cl17834 762376001588 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376001589 DNA binding residues [nucleotide binding] 762376001590 Membrane transport protein; Region: Mem_trans; cl09117 762376001591 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 762376001592 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762376001593 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 762376001594 ligand binding site [chemical binding]; other site 762376001595 NAD binding site [chemical binding]; other site 762376001596 dimerization interface [polypeptide binding]; other site 762376001597 catalytic site [active] 762376001598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376001599 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 762376001600 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 762376001601 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376001602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001603 DNA-binding site [nucleotide binding]; DNA binding site 762376001604 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 762376001605 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 762376001606 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 762376001607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762376001608 muropeptide transporter; Reviewed; Region: ampG; PRK11902 762376001609 muropeptide transporter; Validated; Region: ampG; cl17669 762376001610 universal stress protein UspE; Provisional; Region: PRK11175 762376001611 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376001612 Ligand Binding Site [chemical binding]; other site 762376001613 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376001614 Ligand Binding Site [chemical binding]; other site 762376001615 Predicted membrane protein [Function unknown]; Region: COG2860 762376001616 UPF0126 domain; Region: UPF0126; pfam03458 762376001617 UPF0126 domain; Region: UPF0126; pfam03458 762376001618 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376001619 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001620 DNA-binding site [nucleotide binding]; DNA binding site 762376001621 FCD domain; Region: FCD; pfam07729 762376001622 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 762376001623 putative active site [active] 762376001624 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 762376001625 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 762376001626 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 762376001627 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 762376001628 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376001629 putative metal binding site [ion binding]; other site 762376001630 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376001632 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 762376001633 putative dimerization interface [polypeptide binding]; other site 762376001634 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376001635 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 762376001636 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 762376001637 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376001638 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376001639 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376001640 N-terminal plug; other site 762376001641 ligand-binding site [chemical binding]; other site 762376001642 fec operon regulator FecR; Reviewed; Region: PRK09774 762376001643 FecR protein; Region: FecR; pfam04773 762376001644 RNA polymerase sigma factor; Reviewed; Region: PRK12523 762376001645 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376001646 DNA binding residues [nucleotide binding] 762376001647 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 762376001648 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 762376001649 ligand binding site [chemical binding]; other site 762376001650 NAD binding site [chemical binding]; other site 762376001651 tetramer interface [polypeptide binding]; other site 762376001652 catalytic site [active] 762376001653 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 762376001654 L-serine binding site [chemical binding]; other site 762376001655 ACT domain interface; other site 762376001656 Protein of unknown function, DUF; Region: DUF411; cl01142 762376001657 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 762376001658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376001659 dimerization interface [polypeptide binding]; other site 762376001660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376001661 dimer interface [polypeptide binding]; other site 762376001662 phosphorylation site [posttranslational modification] 762376001663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376001664 ATP binding site [chemical binding]; other site 762376001665 Mg2+ binding site [ion binding]; other site 762376001666 G-X-G motif; other site 762376001667 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 762376001668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376001669 active site 762376001670 phosphorylation site [posttranslational modification] 762376001671 intermolecular recognition site; other site 762376001672 dimerization interface [polypeptide binding]; other site 762376001673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376001674 DNA binding site [nucleotide binding] 762376001675 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 762376001676 PAS domain; Region: PAS; smart00091 762376001677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376001678 dimer interface [polypeptide binding]; other site 762376001679 phosphorylation site [posttranslational modification] 762376001680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376001681 ATP binding site [chemical binding]; other site 762376001682 Mg2+ binding site [ion binding]; other site 762376001683 G-X-G motif; other site 762376001684 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 762376001685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376001686 active site 762376001687 phosphorylation site [posttranslational modification] 762376001688 intermolecular recognition site; other site 762376001689 dimerization interface [polypeptide binding]; other site 762376001690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376001691 DNA binding site [nucleotide binding] 762376001692 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 762376001693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376001694 S-adenosylmethionine binding site [chemical binding]; other site 762376001695 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 762376001696 SCP-2 sterol transfer family; Region: SCP2; pfam02036 762376001697 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 762376001698 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 762376001699 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 762376001700 dinuclear metal binding motif [ion binding]; other site 762376001701 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 762376001702 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 762376001703 active site 762376001704 nucleotide binding site [chemical binding]; other site 762376001705 HIGH motif; other site 762376001706 KMSKS motif; other site 762376001707 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 762376001708 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 762376001709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376001710 S-adenosylmethionine binding site [chemical binding]; other site 762376001711 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762376001712 dimer interface [polypeptide binding]; other site 762376001713 substrate binding site [chemical binding]; other site 762376001714 ATP binding site [chemical binding]; other site 762376001715 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 762376001716 ThiS interaction site; other site 762376001717 putative active site [active] 762376001718 tetramer interface [polypeptide binding]; other site 762376001719 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 762376001720 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 762376001721 cobalamin binding residues [chemical binding]; other site 762376001722 putative BtuC binding residues; other site 762376001723 dimer interface [polypeptide binding]; other site 762376001724 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 762376001725 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376001726 N-terminal plug; other site 762376001727 ligand-binding site [chemical binding]; other site 762376001728 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 762376001729 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 762376001730 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 762376001731 substrate binding pocket [chemical binding]; other site 762376001732 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 762376001733 B12 binding site [chemical binding]; other site 762376001734 cobalt ligand [ion binding]; other site 762376001735 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 762376001736 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 762376001737 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 762376001738 active site 762376001739 oxalacetate binding site [chemical binding]; other site 762376001740 citrylCoA binding site [chemical binding]; other site 762376001741 coenzyme A binding site [chemical binding]; other site 762376001742 catalytic triad [active] 762376001743 acyl-CoA synthetase; Validated; Region: PRK06188 762376001744 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376001745 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 762376001746 acyl-activating enzyme (AAE) consensus motif; other site 762376001747 putative AMP binding site [chemical binding]; other site 762376001748 putative active site [active] 762376001749 putative CoA binding site [chemical binding]; other site 762376001750 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376001751 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376001752 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376001753 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 762376001754 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 762376001755 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 762376001756 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 762376001757 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 762376001758 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376001760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376001761 dimerization interface [polypeptide binding]; other site 762376001762 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 762376001763 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376001764 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 762376001765 putative C-terminal domain interface [polypeptide binding]; other site 762376001766 putative GSH binding site (G-site) [chemical binding]; other site 762376001767 putative dimer interface [polypeptide binding]; other site 762376001768 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 762376001769 dimer interface [polypeptide binding]; other site 762376001770 N-terminal domain interface [polypeptide binding]; other site 762376001771 putative substrate binding pocket (H-site) [chemical binding]; other site 762376001772 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 762376001773 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376001774 classical (c) SDRs; Region: SDR_c; cd05233 762376001775 NAD(P) binding site [chemical binding]; other site 762376001776 active site 762376001777 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376001778 classical (c) SDRs; Region: SDR_c; cd05233 762376001779 NAD(P) binding site [chemical binding]; other site 762376001780 active site 762376001781 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376001782 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376001783 Walker A/P-loop; other site 762376001784 ATP binding site [chemical binding]; other site 762376001785 Q-loop/lid; other site 762376001786 ABC transporter signature motif; other site 762376001787 Walker B; other site 762376001788 D-loop; other site 762376001789 H-loop/switch region; other site 762376001790 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376001791 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376001792 Walker A/P-loop; other site 762376001793 ATP binding site [chemical binding]; other site 762376001794 Q-loop/lid; other site 762376001795 ABC transporter signature motif; other site 762376001796 Walker B; other site 762376001797 D-loop; other site 762376001798 H-loop/switch region; other site 762376001799 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376001800 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376001801 TM-ABC transporter signature motif; other site 762376001802 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376001803 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376001804 TM-ABC transporter signature motif; other site 762376001805 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376001806 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376001807 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376001808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001809 NAD(P) binding site [chemical binding]; other site 762376001810 active site 762376001811 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376001812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001813 DNA-binding site [nucleotide binding]; DNA binding site 762376001814 FCD domain; Region: FCD; pfam07729 762376001815 classical (c) SDRs; Region: SDR_c; cd05233 762376001816 NAD(P) binding site [chemical binding]; other site 762376001817 active site 762376001818 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 762376001819 active site clefts [active] 762376001820 zinc binding site [ion binding]; other site 762376001821 dimer interface [polypeptide binding]; other site 762376001822 psiF repeat; Region: PsiF_repeat; pfam07769 762376001823 psiF repeat; Region: PsiF_repeat; pfam07769 762376001824 indole acetimide hydrolase; Validated; Region: PRK07488 762376001825 Amidase; Region: Amidase; pfam01425 762376001826 Methyltransferase domain; Region: Methyltransf_31; pfam13847 762376001827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376001828 S-adenosylmethionine binding site [chemical binding]; other site 762376001829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376001830 salt bridge; other site 762376001831 non-specific DNA binding site [nucleotide binding]; other site 762376001832 sequence-specific DNA binding site [nucleotide binding]; other site 762376001833 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376001834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376001835 DNA-binding site [nucleotide binding]; DNA binding site 762376001836 FCD domain; Region: FCD; pfam07729 762376001837 acetolactate synthase catalytic subunit; Validated; Region: PRK06112 762376001838 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376001839 PYR/PP interface [polypeptide binding]; other site 762376001840 dimer interface [polypeptide binding]; other site 762376001841 TPP binding site [chemical binding]; other site 762376001842 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376001843 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 762376001844 TPP-binding site [chemical binding]; other site 762376001845 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 762376001846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001847 NAD(P) binding site [chemical binding]; other site 762376001848 active site 762376001849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376001850 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 762376001851 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762376001852 minor groove reading motif; other site 762376001853 helix-hairpin-helix signature motif; other site 762376001854 substrate binding pocket [chemical binding]; other site 762376001855 active site 762376001856 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 762376001857 DNA binding and oxoG recognition site [nucleotide binding] 762376001858 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 762376001859 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 762376001860 dimer interface [polypeptide binding]; other site 762376001861 PYR/PP interface [polypeptide binding]; other site 762376001862 TPP binding site [chemical binding]; other site 762376001863 substrate binding site [chemical binding]; other site 762376001864 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 762376001865 TPP-binding site; other site 762376001866 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 762376001867 glycerol kinase; Provisional; Region: glpK; PRK00047 762376001868 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 762376001869 N- and C-terminal domain interface [polypeptide binding]; other site 762376001870 homotetramer interface [polypeptide binding]; other site 762376001871 homodimer interface [polypeptide binding]; other site 762376001872 active site 762376001873 glycerol binding site [chemical binding]; other site 762376001874 FBP binding site [chemical binding]; other site 762376001875 MgATP binding site [chemical binding]; other site 762376001876 protein IIAGlc interface [polypeptide binding]; other site 762376001877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376001878 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376001879 putative substrate translocation pore; other site 762376001880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376001881 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 762376001882 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 762376001883 Pantoate-beta-alanine ligase; Region: PanC; cd00560 762376001884 pantoate--beta-alanine ligase; Region: panC; TIGR00018 762376001885 active site 762376001886 ATP-binding site [chemical binding]; other site 762376001887 pantoate-binding site; other site 762376001888 HXXH motif; other site 762376001889 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376001890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376001891 DNA binding residues [nucleotide binding] 762376001892 dimerization interface [polypeptide binding]; other site 762376001893 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 762376001894 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 762376001895 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 762376001896 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 762376001897 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 762376001898 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 762376001899 CoA-binding site [chemical binding]; other site 762376001900 ATP-binding [chemical binding]; other site 762376001901 hypothetical protein; Provisional; Region: PRK05287 762376001902 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376001903 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376001904 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376001905 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 762376001906 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 762376001907 Protein export membrane protein; Region: SecD_SecF; cl14618 762376001908 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 762376001909 short chain dehydrogenase; Provisional; Region: PRK12744 762376001910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376001911 NAD(P) binding site [chemical binding]; other site 762376001912 active site 762376001913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376001914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376001915 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 762376001916 putative effector binding pocket; other site 762376001917 putative dimerization interface [polypeptide binding]; other site 762376001918 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376001919 Amidase; Region: Amidase; cl11426 762376001920 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376001921 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 762376001922 putative ligand binding site [chemical binding]; other site 762376001923 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376001924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376001925 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376001926 putative dimerization interface [polypeptide binding]; other site 762376001927 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376001928 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376001929 TM-ABC transporter signature motif; other site 762376001930 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376001931 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376001932 TM-ABC transporter signature motif; other site 762376001933 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376001934 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376001935 Walker A/P-loop; other site 762376001936 ATP binding site [chemical binding]; other site 762376001937 Q-loop/lid; other site 762376001938 ABC transporter signature motif; other site 762376001939 Walker B; other site 762376001940 D-loop; other site 762376001941 H-loop/switch region; other site 762376001942 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376001943 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376001944 Walker A/P-loop; other site 762376001945 ATP binding site [chemical binding]; other site 762376001946 Q-loop/lid; other site 762376001947 ABC transporter signature motif; other site 762376001948 Walker B; other site 762376001949 D-loop; other site 762376001950 H-loop/switch region; other site 762376001951 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 762376001952 hypothetical protein; Provisional; Region: PRK08999 762376001953 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 762376001954 active site 762376001955 8-oxo-dGMP binding site [chemical binding]; other site 762376001956 nudix motif; other site 762376001957 metal binding site [ion binding]; metal-binding site 762376001958 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 762376001959 active site 762376001960 thiamine phosphate binding site [chemical binding]; other site 762376001961 pyrophosphate binding site [ion binding]; other site 762376001962 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 762376001963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376001964 Walker A motif; other site 762376001965 ATP binding site [chemical binding]; other site 762376001966 Walker B motif; other site 762376001967 arginine finger; other site 762376001968 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 762376001969 heterotetramer interface [polypeptide binding]; other site 762376001970 active site pocket [active] 762376001971 cleavage site 762376001972 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376001973 MarR family; Region: MarR; pfam01047 762376001974 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376001975 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 762376001976 putative ligand binding site [chemical binding]; other site 762376001977 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376001978 TM-ABC transporter signature motif; other site 762376001979 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376001980 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376001981 TM-ABC transporter signature motif; other site 762376001982 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376001983 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376001984 Walker A/P-loop; other site 762376001985 ATP binding site [chemical binding]; other site 762376001986 Q-loop/lid; other site 762376001987 ABC transporter signature motif; other site 762376001988 Walker B; other site 762376001989 D-loop; other site 762376001990 H-loop/switch region; other site 762376001991 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376001992 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376001993 Walker A/P-loop; other site 762376001994 ATP binding site [chemical binding]; other site 762376001995 Q-loop/lid; other site 762376001996 ABC transporter signature motif; other site 762376001997 Walker B; other site 762376001998 D-loop; other site 762376001999 H-loop/switch region; other site 762376002000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376002001 dimerization interface [polypeptide binding]; other site 762376002002 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 762376002003 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 762376002004 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 762376002005 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376002006 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376002007 metal binding site [ion binding]; metal-binding site 762376002008 active site 762376002009 I-site; other site 762376002010 PAS domain; Region: PAS_9; pfam13426 762376002011 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 762376002012 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376002013 PAS domain; Region: PAS_9; pfam13426 762376002014 putative active site [active] 762376002015 heme pocket [chemical binding]; other site 762376002016 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 762376002017 GAF domain; Region: GAF; cl17456 762376002018 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376002019 metal binding site [ion binding]; metal-binding site 762376002020 active site 762376002021 I-site; other site 762376002022 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376002023 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 762376002024 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 762376002025 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 762376002026 active site 762376002027 FMN binding site [chemical binding]; other site 762376002028 substrate binding site [chemical binding]; other site 762376002029 homotetramer interface [polypeptide binding]; other site 762376002030 catalytic residue [active] 762376002031 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376002032 classical (c) SDRs; Region: SDR_c; cd05233 762376002033 NAD(P) binding site [chemical binding]; other site 762376002034 active site 762376002035 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376002036 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376002037 substrate binding site [chemical binding]; other site 762376002038 oxyanion hole (OAH) forming residues; other site 762376002039 trimer interface [polypeptide binding]; other site 762376002040 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376002041 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376002042 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376002043 active site 762376002044 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376002045 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 762376002046 acyl-activating enzyme (AAE) consensus motif; other site 762376002047 AMP binding site [chemical binding]; other site 762376002048 active site 762376002049 CoA binding site [chemical binding]; other site 762376002050 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 762376002051 active site 762376002052 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376002053 homotrimer interaction site [polypeptide binding]; other site 762376002054 putative active site [active] 762376002055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376002056 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376002057 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376002058 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 762376002059 putative ligand binding site [chemical binding]; other site 762376002060 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 762376002061 SnoaL-like domain; Region: SnoaL_2; pfam12680 762376002062 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 762376002063 iron-sulfur cluster [ion binding]; other site 762376002064 [2Fe-2S] cluster binding site [ion binding]; other site 762376002065 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 762376002066 putative alpha subunit interface [polypeptide binding]; other site 762376002067 putative active site [active] 762376002068 putative substrate binding site [chemical binding]; other site 762376002069 Fe binding site [ion binding]; other site 762376002070 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 762376002071 inter-subunit interface; other site 762376002072 Isochorismatase family; Region: Isochorismatase; pfam00857 762376002073 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 762376002074 catalytic triad [active] 762376002075 conserved cis-peptide bond; other site 762376002076 short chain dehydrogenase; Provisional; Region: PRK08265 762376002077 classical (c) SDRs; Region: SDR_c; cd05233 762376002078 NAD(P) binding site [chemical binding]; other site 762376002079 active site 762376002080 Protein of unknown function (DUF342); Region: DUF342; pfam03961 762376002081 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 762376002082 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762376002083 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376002084 catalytic residue [active] 762376002085 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 762376002086 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376002087 inhibitor-cofactor binding pocket; inhibition site 762376002088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376002089 catalytic residue [active] 762376002090 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 762376002091 thiamine phosphate binding site [chemical binding]; other site 762376002092 active site 762376002093 pyrophosphate binding site [ion binding]; other site 762376002094 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 762376002095 substrate binding site [chemical binding]; other site 762376002096 ATP binding site [chemical binding]; other site 762376002097 Rubredoxin [Energy production and conversion]; Region: COG1773 762376002098 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 762376002099 iron binding site [ion binding]; other site 762376002100 hypothetical protein; Validated; Region: PRK00228 762376002101 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 762376002102 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762376002103 dihydroorotase; Provisional; Region: PRK07627 762376002104 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376002105 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376002106 active site 762376002107 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 762376002108 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762376002109 putative acyl-acceptor binding pocket; other site 762376002110 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 762376002111 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 762376002112 active site 762376002113 metal binding site [ion binding]; metal-binding site 762376002114 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 762376002115 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 762376002116 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 762376002117 Transglycosylase; Region: Transgly; cl17702 762376002118 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 762376002119 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 762376002120 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 762376002121 shikimate binding site; other site 762376002122 NAD(P) binding site [chemical binding]; other site 762376002123 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 762376002124 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376002125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376002126 Walker A/P-loop; other site 762376002127 ATP binding site [chemical binding]; other site 762376002128 Q-loop/lid; other site 762376002129 ABC transporter signature motif; other site 762376002130 Walker B; other site 762376002131 D-loop; other site 762376002132 H-loop/switch region; other site 762376002133 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 762376002134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376002135 dimer interface [polypeptide binding]; other site 762376002136 conserved gate region; other site 762376002137 ABC-ATPase subunit interface; other site 762376002138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 762376002139 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 762376002140 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 762376002141 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 762376002142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376002143 dimer interface [polypeptide binding]; other site 762376002144 phosphorylation site [posttranslational modification] 762376002145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376002146 ATP binding site [chemical binding]; other site 762376002147 Mg2+ binding site [ion binding]; other site 762376002148 G-X-G motif; other site 762376002149 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 762376002150 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 762376002151 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376002152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376002153 active site 762376002154 phosphorylation site [posttranslational modification] 762376002155 intermolecular recognition site; other site 762376002156 dimerization interface [polypeptide binding]; other site 762376002157 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376002158 DNA binding site [nucleotide binding] 762376002159 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 762376002160 RNB domain; Region: RNB; pfam00773 762376002161 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 762376002162 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376002163 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 762376002164 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762376002165 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376002166 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376002167 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 762376002168 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762376002169 catalytic residues [active] 762376002170 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 762376002171 Dehydroquinase class II; Region: DHquinase_II; pfam01220 762376002172 trimer interface [polypeptide binding]; other site 762376002173 active site 762376002174 dimer interface [polypeptide binding]; other site 762376002175 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 762376002176 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762376002177 carboxyltransferase (CT) interaction site; other site 762376002178 biotinylation site [posttranslational modification]; other site 762376002179 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 762376002180 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376002181 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 762376002182 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 762376002183 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 762376002184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376002185 S-adenosylmethionine binding site [chemical binding]; other site 762376002186 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 762376002187 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 762376002188 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 762376002189 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 762376002190 substrate binding site [chemical binding]; other site 762376002191 ATP binding site [chemical binding]; other site 762376002192 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 762376002193 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 762376002194 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 762376002195 DltD C-terminal region; Region: DltD_C; pfam04914 762376002196 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 762376002197 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 762376002198 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 762376002199 acyl-activating enzyme (AAE) consensus motif; other site 762376002200 AMP binding site [chemical binding]; other site 762376002201 YGGT family; Region: YGGT; pfam02325 762376002202 YGGT family; Region: YGGT; pfam02325 762376002203 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 762376002204 dimer interface [polypeptide binding]; other site 762376002205 putative radical transfer pathway; other site 762376002206 diiron center [ion binding]; other site 762376002207 tyrosyl radical; other site 762376002208 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 762376002209 ATP cone domain; Region: ATP-cone; pfam03477 762376002210 Class I ribonucleotide reductase; Region: RNR_I; cd01679 762376002211 active site 762376002212 dimer interface [polypeptide binding]; other site 762376002213 catalytic residues [active] 762376002214 effector binding site; other site 762376002215 R2 peptide binding site; other site 762376002216 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 762376002217 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 762376002218 dimer interface [polypeptide binding]; other site 762376002219 PYR/PP interface [polypeptide binding]; other site 762376002220 TPP binding site [chemical binding]; other site 762376002221 substrate binding site [chemical binding]; other site 762376002222 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 762376002223 TPP-binding site [chemical binding]; other site 762376002224 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 762376002225 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376002226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376002227 putative DNA binding site [nucleotide binding]; other site 762376002228 putative Zn2+ binding site [ion binding]; other site 762376002229 AsnC family; Region: AsnC_trans_reg; pfam01037 762376002230 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376002231 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762376002232 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762376002233 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 762376002234 catalytic site [active] 762376002235 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376002236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376002237 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376002238 putative dimerization interface [polypeptide binding]; other site 762376002239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376002240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376002241 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 762376002242 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762376002243 HIGH motif; other site 762376002244 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762376002245 active site 762376002246 KMSKS motif; other site 762376002247 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376002248 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762376002249 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762376002250 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762376002251 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376002252 Coenzyme A binding pocket [chemical binding]; other site 762376002253 Isochorismatase family; Region: Isochorismatase; pfam00857 762376002254 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 762376002255 catalytic triad [active] 762376002256 conserved cis-peptide bond; other site 762376002257 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376002258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376002259 dimer interface [polypeptide binding]; other site 762376002260 conserved gate region; other site 762376002261 putative PBP binding loops; other site 762376002262 ABC-ATPase subunit interface; other site 762376002263 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376002264 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762376002265 Walker A/P-loop; other site 762376002266 ATP binding site [chemical binding]; other site 762376002267 Q-loop/lid; other site 762376002268 ABC transporter signature motif; other site 762376002269 Walker B; other site 762376002270 D-loop; other site 762376002271 H-loop/switch region; other site 762376002272 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 762376002273 NMT1/THI5 like; Region: NMT1; pfam09084 762376002274 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 762376002275 putative hydrolase; Provisional; Region: PRK11460 762376002276 hypothetical protein; Provisional; Region: PRK05255 762376002277 peptidase PmbA; Provisional; Region: PRK11040 762376002278 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 762376002279 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 762376002280 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376002281 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376002282 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376002283 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376002284 TM-ABC transporter signature motif; other site 762376002285 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376002286 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376002287 TM-ABC transporter signature motif; other site 762376002288 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376002289 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376002290 Walker A/P-loop; other site 762376002291 ATP binding site [chemical binding]; other site 762376002292 Q-loop/lid; other site 762376002293 ABC transporter signature motif; other site 762376002294 Walker B; other site 762376002295 D-loop; other site 762376002296 H-loop/switch region; other site 762376002297 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376002298 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376002299 Walker A/P-loop; other site 762376002300 ATP binding site [chemical binding]; other site 762376002301 Q-loop/lid; other site 762376002302 ABC transporter signature motif; other site 762376002303 Walker B; other site 762376002304 D-loop; other site 762376002305 H-loop/switch region; other site 762376002306 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 762376002307 23S rRNA interface [nucleotide binding]; other site 762376002308 L3 interface [polypeptide binding]; other site 762376002309 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 762376002310 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 762376002311 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 762376002312 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 762376002313 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 762376002314 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 762376002315 putative peptidase; Provisional; Region: PRK11649 762376002316 Peptidase family M23; Region: Peptidase_M23; pfam01551 762376002317 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 762376002318 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 762376002319 active site 762376002320 HIGH motif; other site 762376002321 dimer interface [polypeptide binding]; other site 762376002322 KMSKS motif; other site 762376002323 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376002324 RNA binding surface [nucleotide binding]; other site 762376002325 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 762376002326 substrate binding site [chemical binding]; other site 762376002327 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376002328 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 762376002329 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 762376002330 dimer interface [polypeptide binding]; other site 762376002331 active site 762376002332 glycine-pyridoxal phosphate binding site [chemical binding]; other site 762376002333 folate binding site [chemical binding]; other site 762376002334 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 762376002335 ATP cone domain; Region: ATP-cone; pfam03477 762376002336 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376002337 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 762376002338 conserved cys residue [active] 762376002339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376002340 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 762376002341 Isochorismatase family; Region: Isochorismatase; pfam00857 762376002342 catalytic triad [active] 762376002343 conserved cis-peptide bond; other site 762376002344 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 762376002345 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 762376002346 catalytic motif [active] 762376002347 Zn binding site [ion binding]; other site 762376002348 RibD C-terminal domain; Region: RibD_C; cl17279 762376002349 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 762376002350 PrkA family serine protein kinase; Provisional; Region: PRK15455 762376002351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 762376002352 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 762376002353 hypothetical protein; Provisional; Region: PRK05325 762376002354 SpoVR family protein; Provisional; Region: PRK11767 762376002355 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 762376002356 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 762376002357 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376002358 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376002359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376002360 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376002361 putative dimerization interface [polypeptide binding]; other site 762376002362 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 762376002363 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 762376002364 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 762376002365 dimerization interface [polypeptide binding]; other site 762376002366 active site 762376002367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376002368 Protein of unknown function (DUF533); Region: DUF533; pfam04391 762376002369 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 762376002370 putative metal binding site [ion binding]; other site 762376002371 OsmC-like protein; Region: OsmC; pfam02566 762376002372 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 762376002373 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 762376002374 NAD binding site [chemical binding]; other site 762376002375 homotetramer interface [polypeptide binding]; other site 762376002376 homodimer interface [polypeptide binding]; other site 762376002377 substrate binding site [chemical binding]; other site 762376002378 active site 762376002379 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376002380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376002381 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376002382 dimerization interface [polypeptide binding]; other site 762376002383 substrate binding pocket [chemical binding]; other site 762376002384 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 762376002385 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 762376002386 putative active site [active] 762376002387 Zn binding site [ion binding]; other site 762376002388 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 762376002389 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 762376002390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376002391 catalytic residue [active] 762376002392 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 762376002393 Predicted transcriptional regulators [Transcription]; Region: COG1695 762376002394 Transcriptional regulator PadR-like family; Region: PadR; cl17335 762376002395 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 762376002396 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762376002397 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376002398 catalytic residue [active] 762376002399 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762376002400 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762376002401 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 762376002402 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 762376002403 RNA/DNA hybrid binding site [nucleotide binding]; other site 762376002404 active site 762376002405 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376002406 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376002407 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376002408 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 762376002409 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 762376002410 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 762376002411 active site 762376002412 catalytic site [active] 762376002413 substrate binding site [chemical binding]; other site 762376002414 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 762376002415 LexA regulated protein; Provisional; Region: PRK11675 762376002416 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 762376002417 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 762376002418 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 762376002419 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 762376002420 Ligand binding site; other site 762376002421 Putative Catalytic site; other site 762376002422 DXD motif; other site 762376002423 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 762376002424 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 762376002425 GtrA-like protein; Region: GtrA; pfam04138 762376002426 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 762376002427 putative active site [active] 762376002428 YdjC motif; other site 762376002429 Mg binding site [ion binding]; other site 762376002430 putative homodimer interface [polypeptide binding]; other site 762376002431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376002432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376002433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376002434 dimerization interface [polypeptide binding]; other site 762376002435 Predicted membrane protein [Function unknown]; Region: COG4125 762376002436 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 762376002437 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 762376002438 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376002439 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376002440 DNA-binding site [nucleotide binding]; DNA binding site 762376002441 FCD domain; Region: FCD; pfam07729 762376002442 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376002443 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376002444 TM-ABC transporter signature motif; other site 762376002445 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376002446 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376002447 TM-ABC transporter signature motif; other site 762376002448 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376002449 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376002450 putative ligand binding site [chemical binding]; other site 762376002451 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376002452 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376002453 Walker A/P-loop; other site 762376002454 ATP binding site [chemical binding]; other site 762376002455 Q-loop/lid; other site 762376002456 ABC transporter signature motif; other site 762376002457 Walker B; other site 762376002458 D-loop; other site 762376002459 H-loop/switch region; other site 762376002460 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376002461 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376002462 Walker A/P-loop; other site 762376002463 ATP binding site [chemical binding]; other site 762376002464 Q-loop/lid; other site 762376002465 ABC transporter signature motif; other site 762376002466 Walker B; other site 762376002467 D-loop; other site 762376002468 H-loop/switch region; other site 762376002469 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376002470 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762376002471 inhibitor site; inhibition site 762376002472 active site 762376002473 dimer interface [polypeptide binding]; other site 762376002474 catalytic residue [active] 762376002475 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762376002476 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762376002477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376002478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376002479 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 762376002480 putative dimerization interface [polypeptide binding]; other site 762376002481 LrgA family; Region: LrgA; cl00608 762376002482 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 762376002483 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376002484 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376002485 EamA-like transporter family; Region: EamA; pfam00892 762376002486 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376002487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376002488 DNA-binding site [nucleotide binding]; DNA binding site 762376002489 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376002490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376002491 homodimer interface [polypeptide binding]; other site 762376002492 catalytic residue [active] 762376002493 Putative phosphatase (DUF442); Region: DUF442; cl17385 762376002494 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376002495 Ligand Binding Site [chemical binding]; other site 762376002496 elongation factor G; Reviewed; Region: PRK00007 762376002497 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 762376002498 G1 box; other site 762376002499 putative GEF interaction site [polypeptide binding]; other site 762376002500 GTP/Mg2+ binding site [chemical binding]; other site 762376002501 Switch I region; other site 762376002502 G2 box; other site 762376002503 G3 box; other site 762376002504 Switch II region; other site 762376002505 G4 box; other site 762376002506 G5 box; other site 762376002507 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 762376002508 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 762376002509 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 762376002510 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376002511 EamA-like transporter family; Region: EamA; pfam00892 762376002512 EamA-like transporter family; Region: EamA; pfam00892 762376002513 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376002514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376002515 putative DNA binding site [nucleotide binding]; other site 762376002516 putative Zn2+ binding site [ion binding]; other site 762376002517 AsnC family; Region: AsnC_trans_reg; pfam01037 762376002518 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376002519 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; cl03910 762376002520 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 762376002521 putative deacylase active site [active] 762376002522 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 762376002523 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762376002524 Walker A/P-loop; other site 762376002525 ATP binding site [chemical binding]; other site 762376002526 Q-loop/lid; other site 762376002527 ABC transporter signature motif; other site 762376002528 Walker B; other site 762376002529 D-loop; other site 762376002530 H-loop/switch region; other site 762376002531 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 762376002532 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762376002533 ABC-ATPase subunit interface; other site 762376002534 dimer interface [polypeptide binding]; other site 762376002535 putative PBP binding regions; other site 762376002536 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 762376002537 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 762376002538 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376002539 ligand binding site [chemical binding]; other site 762376002540 translocation protein TolB; Provisional; Region: tolB; PRK02889 762376002541 TolB amino-terminal domain; Region: TolB_N; pfam04052 762376002542 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762376002543 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762376002544 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762376002545 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 762376002546 TolA protein; Region: tolA_full; TIGR02794 762376002547 TonB C terminal; Region: TonB_2; pfam13103 762376002548 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 762376002549 TolR protein; Region: tolR; TIGR02801 762376002550 TolQ protein; Region: tolQ; TIGR02796 762376002551 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 762376002552 active site 762376002553 prolyl-tRNA synthetase; Provisional; Region: PRK09194 762376002554 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 762376002555 dimer interface [polypeptide binding]; other site 762376002556 motif 1; other site 762376002557 active site 762376002558 motif 2; other site 762376002559 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 762376002560 putative deacylase active site [active] 762376002561 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762376002562 active site 762376002563 motif 3; other site 762376002564 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 762376002565 anticodon binding site; other site 762376002566 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 762376002567 putative active site [active] 762376002568 Ap4A binding site [chemical binding]; other site 762376002569 nudix motif; other site 762376002570 putative metal binding site [ion binding]; other site 762376002571 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 762376002572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376002573 active site 762376002574 phosphorylation site [posttranslational modification] 762376002575 intermolecular recognition site; other site 762376002576 dimerization interface [polypeptide binding]; other site 762376002577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376002578 DNA binding site [nucleotide binding] 762376002579 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 762376002580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376002581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376002582 dimer interface [polypeptide binding]; other site 762376002583 phosphorylation site [posttranslational modification] 762376002584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376002585 ATP binding site [chemical binding]; other site 762376002586 Mg2+ binding site [ion binding]; other site 762376002587 G-X-G motif; other site 762376002588 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 762376002589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 762376002590 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 762376002591 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 762376002592 putative ligand binding site [chemical binding]; other site 762376002593 NAD binding site [chemical binding]; other site 762376002594 dimerization interface [polypeptide binding]; other site 762376002595 catalytic site [active] 762376002596 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376002597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376002598 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 762376002599 putative effector binding pocket; other site 762376002600 putative dimerization interface [polypeptide binding]; other site 762376002601 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 762376002602 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762376002603 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376002604 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762376002605 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 762376002606 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376002607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 762376002608 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 762376002609 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 762376002610 Cell division protein ZapA; Region: ZapA; pfam05164 762376002611 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 762376002612 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 762376002613 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 762376002614 Cytochrome c; Region: Cytochrom_C; cl11414 762376002615 methionine sulfoxide reductase A; Provisional; Region: PRK14054 762376002616 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 762376002617 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 762376002618 dimer interface [polypeptide binding]; other site 762376002619 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 762376002620 active site 762376002621 Fe binding site [ion binding]; other site 762376002622 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 762376002623 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376002624 putative DNA binding site [nucleotide binding]; other site 762376002625 putative Zn2+ binding site [ion binding]; other site 762376002626 AsnC family; Region: AsnC_trans_reg; pfam01037 762376002627 Predicted membrane protein [Function unknown]; Region: COG3671 762376002628 SWI complex, BAF60b domains; Region: SWIB; smart00151 762376002629 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376002630 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 762376002631 metal binding site [ion binding]; metal-binding site 762376002632 putative dimer interface [polypeptide binding]; other site 762376002633 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 762376002634 active site 762376002635 substrate binding pocket [chemical binding]; other site 762376002636 dimer interface [polypeptide binding]; other site 762376002637 ABC transporter ATPase component; Reviewed; Region: PRK11147 762376002638 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376002639 ABC transporter; Region: ABC_tran_2; pfam12848 762376002640 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376002641 cell division protein MraZ; Reviewed; Region: PRK00326 762376002642 MraZ protein; Region: MraZ; pfam02381 762376002643 MraZ protein; Region: MraZ; pfam02381 762376002644 MraW methylase family; Region: Methyltransf_5; cl17771 762376002645 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 762376002646 cell division protein FtsL; Region: ftsL_broad; TIGR02209 762376002647 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 762376002648 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762376002649 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 762376002650 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 762376002651 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762376002652 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376002653 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376002654 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762376002655 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376002656 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376002657 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 762376002658 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 762376002659 Mg++ binding site [ion binding]; other site 762376002660 putative catalytic motif [active] 762376002661 putative substrate binding site [chemical binding]; other site 762376002662 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 762376002663 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 762376002664 NAD binding site [chemical binding]; other site 762376002665 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376002666 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376002667 cell division protein FtsW; Region: ftsW; TIGR02614 762376002668 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 762376002669 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 762376002670 active site 762376002671 homodimer interface [polypeptide binding]; other site 762376002672 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 762376002673 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762376002674 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376002675 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376002676 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 762376002677 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 762376002678 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762376002679 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 762376002680 Cell division protein FtsQ; Region: FtsQ; pfam03799 762376002681 cell division protein FtsA; Region: ftsA; TIGR01174 762376002682 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762376002683 nucleotide binding site [chemical binding]; other site 762376002684 Cell division protein FtsA; Region: FtsA; pfam14450 762376002685 cell division protein FtsZ; Validated; Region: PRK09330 762376002686 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 762376002687 nucleotide binding site [chemical binding]; other site 762376002688 SulA interaction site; other site 762376002689 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 762376002690 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 762376002691 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 762376002692 Peptidase family M23; Region: Peptidase_M23; pfam01551 762376002693 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 762376002694 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 762376002695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 762376002696 nucleotide binding region [chemical binding]; other site 762376002697 ATP-binding site [chemical binding]; other site 762376002698 SEC-C motif; Region: SEC-C; pfam02810 762376002699 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 762376002700 AAA domain; Region: AAA_30; pfam13604 762376002701 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 762376002702 AAA domain; Region: AAA_12; pfam13087 762376002703 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 762376002704 putative active site [active] 762376002705 catalytic site [active] 762376002706 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376002707 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376002708 DNA-binding site [nucleotide binding]; DNA binding site 762376002709 FCD domain; Region: FCD; pfam07729 762376002710 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376002711 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 762376002712 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376002713 PYR/PP interface [polypeptide binding]; other site 762376002714 dimer interface [polypeptide binding]; other site 762376002715 TPP binding site [chemical binding]; other site 762376002716 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376002717 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 762376002718 TPP-binding site [chemical binding]; other site 762376002719 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 762376002720 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 762376002721 putative NAD(P) binding site [chemical binding]; other site 762376002722 putative active site [active] 762376002723 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376002724 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376002725 putative DNA binding site [nucleotide binding]; other site 762376002726 putative Zn2+ binding site [ion binding]; other site 762376002727 AsnC family; Region: AsnC_trans_reg; pfam01037 762376002728 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 762376002729 putative active site pocket [active] 762376002730 dimerization interface [polypeptide binding]; other site 762376002731 putative catalytic residue [active] 762376002732 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 762376002733 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 762376002734 MgtE intracellular N domain; Region: MgtE_N; smart00924 762376002735 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 762376002736 Divalent cation transporter; Region: MgtE; cl00786 762376002737 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 762376002738 Predicted membrane protein [Function unknown]; Region: COG2855 762376002739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376002740 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 762376002741 putative dimerization interface [polypeptide binding]; other site 762376002742 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376002743 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 762376002744 metal binding site [ion binding]; metal-binding site 762376002745 putative dimer interface [polypeptide binding]; other site 762376002746 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 762376002747 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 762376002748 acyl-activating enzyme (AAE) consensus motif; other site 762376002749 putative AMP binding site [chemical binding]; other site 762376002750 putative active site [active] 762376002751 putative CoA binding site [chemical binding]; other site 762376002752 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 762376002753 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 762376002754 active site 762376002755 dimerization interface [polypeptide binding]; other site 762376002756 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 762376002757 Uncharacterized conserved protein [Function unknown]; Region: COG4121 762376002758 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 762376002759 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 762376002760 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 762376002761 active site 762376002762 catalytic site [active] 762376002763 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 762376002764 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 762376002765 Walker A/P-loop; other site 762376002766 ATP binding site [chemical binding]; other site 762376002767 Q-loop/lid; other site 762376002768 ABC transporter signature motif; other site 762376002769 Walker B; other site 762376002770 D-loop; other site 762376002771 H-loop/switch region; other site 762376002772 NIL domain; Region: NIL; pfam09383 762376002773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376002774 dimer interface [polypeptide binding]; other site 762376002775 conserved gate region; other site 762376002776 ABC-ATPase subunit interface; other site 762376002777 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 762376002778 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762376002779 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 762376002780 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762376002781 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376002782 dimer interface [polypeptide binding]; other site 762376002783 putative CheW interface [polypeptide binding]; other site 762376002784 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376002785 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376002786 metal binding site [ion binding]; metal-binding site 762376002787 active site 762376002788 I-site; other site 762376002789 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 762376002790 DNA-binding interface [nucleotide binding]; DNA binding site 762376002791 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 762376002792 putative active site [active] 762376002793 Zn binding site [ion binding]; other site 762376002794 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 762376002795 putative active site [active] 762376002796 Zn binding site [ion binding]; other site 762376002797 citrate-proton symporter; Provisional; Region: PRK15075 762376002798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376002799 putative substrate translocation pore; other site 762376002800 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 762376002801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376002802 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376002803 putative substrate translocation pore; other site 762376002804 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 762376002805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376002806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376002807 dimerization interface [polypeptide binding]; other site 762376002808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376002809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376002810 DNA binding residues [nucleotide binding] 762376002811 dimerization interface [polypeptide binding]; other site 762376002812 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 762376002813 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376002814 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 762376002815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376002816 Zn binding site [ion binding]; other site 762376002817 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376002818 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376002819 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 762376002820 ferric uptake regulator; Provisional; Region: fur; PRK09462 762376002821 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762376002822 metal binding site 2 [ion binding]; metal-binding site 762376002823 putative DNA binding helix; other site 762376002824 metal binding site 1 [ion binding]; metal-binding site 762376002825 dimer interface [polypeptide binding]; other site 762376002826 structural Zn2+ binding site [ion binding]; other site 762376002827 Cupin domain; Region: Cupin_2; cl17218 762376002828 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376002829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376002830 Esterase/lipase [General function prediction only]; Region: COG1647 762376002831 TAP-like protein; Region: Abhydrolase_4; pfam08386 762376002832 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 762376002833 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 762376002834 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 762376002835 Sulfatase; Region: Sulfatase; pfam00884 762376002836 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 762376002837 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 762376002838 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376002839 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376002840 metal binding site [ion binding]; metal-binding site 762376002841 active site 762376002842 I-site; other site 762376002843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376002844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376002845 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376002846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376002847 NAD(P) binding site [chemical binding]; other site 762376002848 active site 762376002849 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376002850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376002851 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376002852 DNA binding residues [nucleotide binding] 762376002853 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376002854 FecR protein; Region: FecR; pfam04773 762376002855 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376002856 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376002857 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376002858 N-terminal plug; other site 762376002859 ligand-binding site [chemical binding]; other site 762376002860 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 762376002861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376002862 motif II; other site 762376002863 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376002864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376002865 putative DNA binding site [nucleotide binding]; other site 762376002866 putative Zn2+ binding site [ion binding]; other site 762376002867 AsnC family; Region: AsnC_trans_reg; pfam01037 762376002868 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 762376002869 aspartate aminotransferase; Provisional; Region: PRK06108 762376002870 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376002871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376002872 homodimer interface [polypeptide binding]; other site 762376002873 catalytic residue [active] 762376002874 acetylornithine deacetylase; Provisional; Region: PRK07522 762376002875 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 762376002876 metal binding site [ion binding]; metal-binding site 762376002877 putative dimer interface [polypeptide binding]; other site 762376002878 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376002879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376002880 putative substrate translocation pore; other site 762376002881 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 762376002882 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376002883 ligand binding site [chemical binding]; other site 762376002884 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 762376002885 aromatic arch; other site 762376002886 DCoH dimer interaction site [polypeptide binding]; other site 762376002887 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 762376002888 DCoH tetramer interaction site [polypeptide binding]; other site 762376002889 substrate binding site [chemical binding]; other site 762376002890 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376002891 MarR family; Region: MarR_2; pfam12802 762376002892 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 762376002893 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 762376002894 Mnd1 family; Region: Mnd1; pfam03962 762376002895 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 762376002896 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 762376002897 Substrate binding site; other site 762376002898 metal-binding site 762376002899 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 762376002900 Phosphotransferase enzyme family; Region: APH; pfam01636 762376002901 OstA-like protein; Region: OstA; cl00844 762376002902 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 762376002903 Organic solvent tolerance protein; Region: OstA_C; pfam04453 762376002904 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 762376002905 SurA N-terminal domain; Region: SurA_N; pfam09312 762376002906 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 762376002907 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 762376002908 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 762376002909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376002910 S-adenosylmethionine binding site [chemical binding]; other site 762376002911 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 762376002912 putative transposase OrfB; Reviewed; Region: PHA02517 762376002913 HTH-like domain; Region: HTH_21; pfam13276 762376002914 Integrase core domain; Region: rve; pfam00665 762376002915 Integrase core domain; Region: rve_2; pfam13333 762376002916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376002917 Helix-turn-helix domain; Region: HTH_28; pfam13518 762376002918 Helix-turn-helix domain; Region: HTH_28; pfam13518 762376002919 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 762376002920 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 762376002921 pyruvate kinase; Provisional; Region: PRK05826 762376002922 domain interfaces; other site 762376002923 active site 762376002924 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 762376002925 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 762376002926 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 762376002927 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376002928 active site 762376002929 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 762376002930 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 762376002931 active site 762376002932 catalytic residues [active] 762376002933 metal binding site [ion binding]; metal-binding site 762376002934 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376002935 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 762376002936 dimer interface [polypeptide binding]; other site 762376002937 active site 762376002938 metal binding site [ion binding]; metal-binding site 762376002939 glutathione binding site [chemical binding]; other site 762376002940 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376002941 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376002942 catalytic residue [active] 762376002943 Protein of unknown function DUF45; Region: DUF45; pfam01863 762376002944 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 762376002945 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762376002946 putative acyl-acceptor binding pocket; other site 762376002947 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 762376002948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376002949 active site 762376002950 motif I; other site 762376002951 motif II; other site 762376002952 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 762376002953 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 762376002954 dimer interface [polypeptide binding]; other site 762376002955 motif 1; other site 762376002956 active site 762376002957 motif 2; other site 762376002958 motif 3; other site 762376002959 enoyl-CoA hydratase; Provisional; Region: PRK08252 762376002960 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376002961 substrate binding site [chemical binding]; other site 762376002962 oxyanion hole (OAH) forming residues; other site 762376002963 trimer interface [polypeptide binding]; other site 762376002964 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 762376002965 Fumarase C-terminus; Region: Fumerase_C; pfam05683 762376002966 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376002967 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376002968 enoyl-CoA hydratase; Region: PLN02864 762376002969 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376002970 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 762376002971 dimer interaction site [polypeptide binding]; other site 762376002972 substrate-binding tunnel; other site 762376002973 active site 762376002974 catalytic site [active] 762376002975 substrate binding site [chemical binding]; other site 762376002976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376002977 NAD(P) binding site [chemical binding]; other site 762376002978 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 762376002979 active site 762376002980 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376002981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376002982 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376002983 putative dimerization interface [polypeptide binding]; other site 762376002984 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376002985 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 762376002986 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 762376002987 FMN binding site [chemical binding]; other site 762376002988 substrate binding site [chemical binding]; other site 762376002989 putative catalytic residue [active] 762376002990 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376002991 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 762376002992 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376002993 acyl-activating enzyme (AAE) consensus motif; other site 762376002994 AMP binding site [chemical binding]; other site 762376002995 active site 762376002996 CoA binding site [chemical binding]; other site 762376002997 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376002998 thiolase; Provisional; Region: PRK06158 762376002999 active site 762376003000 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376003001 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376003002 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376003003 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376003004 active site 762376003005 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376003006 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376003007 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376003008 active site 762376003009 enoyl-CoA hydratase; Provisional; Region: PRK08140 762376003010 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376003011 substrate binding site [chemical binding]; other site 762376003012 oxyanion hole (OAH) forming residues; other site 762376003013 trimer interface [polypeptide binding]; other site 762376003014 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 762376003015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376003017 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376003018 putative dimerization interface [polypeptide binding]; other site 762376003019 Uncharacterized conserved protein [Function unknown]; Region: COG3777 762376003020 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376003021 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376003022 active site 2 [active] 762376003023 active site 1 [active] 762376003024 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376003025 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376003026 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 762376003027 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 762376003028 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 762376003029 substrate binding site [chemical binding]; other site 762376003030 ATP binding site [chemical binding]; other site 762376003031 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 762376003032 catalytic center binding site [active] 762376003033 ATP binding site [chemical binding]; other site 762376003034 poly(A) polymerase; Region: pcnB; TIGR01942 762376003035 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 762376003036 active site 762376003037 NTP binding site [chemical binding]; other site 762376003038 metal binding triad [ion binding]; metal-binding site 762376003039 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 762376003040 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 762376003041 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 762376003042 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 762376003043 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 762376003044 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 762376003045 Walker A motif; other site 762376003046 ATP binding site [chemical binding]; other site 762376003047 Walker B motif; other site 762376003048 arginine finger; other site 762376003049 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 762376003050 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 762376003051 dimerization interface [polypeptide binding]; other site 762376003052 putative ATP binding site [chemical binding]; other site 762376003053 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 762376003054 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 762376003055 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 762376003056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376003057 ATP binding site [chemical binding]; other site 762376003058 Mg2+ binding site [ion binding]; other site 762376003059 G-X-G motif; other site 762376003060 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 762376003061 ATP binding site [chemical binding]; other site 762376003062 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 762376003063 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762376003064 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 762376003065 AMIN domain; Region: AMIN; pfam11741 762376003066 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 762376003067 active site 762376003068 metal binding site [ion binding]; metal-binding site 762376003069 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 762376003070 fumarate hydratase; Reviewed; Region: fumC; PRK00485 762376003071 Class II fumarases; Region: Fumarase_classII; cd01362 762376003072 active site 762376003073 tetramer interface [polypeptide binding]; other site 762376003074 Membrane transport protein; Region: Mem_trans; cl09117 762376003075 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376003076 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376003077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376003078 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003079 dimerization interface [polypeptide binding]; other site 762376003080 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 762376003081 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376003082 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376003083 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376003084 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376003085 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376003086 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376003087 active site 762376003088 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376003089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376003090 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 762376003091 putative dimerization interface [polypeptide binding]; other site 762376003092 putative substrate binding pocket [chemical binding]; other site 762376003093 putative transporter; Provisional; Region: PRK11660 762376003094 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 762376003095 Sulfate transporter family; Region: Sulfate_transp; pfam00916 762376003096 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 762376003097 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 762376003098 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 762376003099 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 762376003100 putative active site [active] 762376003101 putative substrate binding site [chemical binding]; other site 762376003102 putative cosubstrate binding site; other site 762376003103 catalytic site [active] 762376003104 hydroxyglutarate oxidase; Provisional; Region: PRK11728 762376003105 Predicted dehydrogenase [General function prediction only]; Region: COG0579 762376003106 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 762376003107 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 762376003108 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 762376003109 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 762376003110 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 762376003111 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 762376003112 putative active site pocket [active] 762376003113 dimerization interface [polypeptide binding]; other site 762376003114 putative catalytic residue [active] 762376003115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376003116 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376003117 putative substrate translocation pore; other site 762376003118 macrolide transporter subunit MacA; Provisional; Region: PRK11578 762376003119 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376003120 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376003121 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 762376003122 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762376003123 Walker A/P-loop; other site 762376003124 ATP binding site [chemical binding]; other site 762376003125 Q-loop/lid; other site 762376003126 ABC transporter signature motif; other site 762376003127 Walker B; other site 762376003128 D-loop; other site 762376003129 H-loop/switch region; other site 762376003130 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762376003131 FtsX-like permease family; Region: FtsX; pfam02687 762376003132 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 762376003133 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376003134 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376003135 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376003136 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376003137 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376003138 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376003139 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376003140 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376003141 enoyl-CoA hydratase; Provisional; Region: PRK06494 762376003142 substrate binding site [chemical binding]; other site 762376003143 oxyanion hole (OAH) forming residues; other site 762376003144 trimer interface [polypeptide binding]; other site 762376003145 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 762376003146 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 762376003147 putative ATP binding site [chemical binding]; other site 762376003148 putative substrate interface [chemical binding]; other site 762376003149 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 762376003150 [2Fe-2S] cluster binding site [ion binding]; other site 762376003151 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 762376003152 inter-subunit interface; other site 762376003153 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376003154 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 762376003155 iron-sulfur cluster [ion binding]; other site 762376003156 [2Fe-2S] cluster binding site [ion binding]; other site 762376003157 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 762376003158 putative alpha subunit interface [polypeptide binding]; other site 762376003159 putative active site [active] 762376003160 putative substrate binding site [chemical binding]; other site 762376003161 Fe binding site [ion binding]; other site 762376003162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376003164 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 762376003165 substrate binding pocket [chemical binding]; other site 762376003166 dimerization interface [polypeptide binding]; other site 762376003167 hypothetical protein; Provisional; Region: PRK07546 762376003168 substrate-cofactor binding pocket; other site 762376003169 homodimer interface [polypeptide binding]; other site 762376003170 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 762376003171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376003172 catalytic residue [active] 762376003173 aminodeoxychorismate synthase; Provisional; Region: PRK07508 762376003174 chorismate binding enzyme; Region: Chorismate_bind; cl10555 762376003175 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 762376003176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376003177 Walker A/P-loop; other site 762376003178 ATP binding site [chemical binding]; other site 762376003179 Q-loop/lid; other site 762376003180 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762376003181 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 762376003182 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762376003183 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762376003184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376003185 Walker A/P-loop; other site 762376003186 ATP binding site [chemical binding]; other site 762376003187 Q-loop/lid; other site 762376003188 ABC transporter signature motif; other site 762376003189 Walker B; other site 762376003190 D-loop; other site 762376003191 H-loop/switch region; other site 762376003192 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376003193 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376003194 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376003195 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 762376003196 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 762376003197 active site 762376003198 intersubunit interface [polypeptide binding]; other site 762376003199 catalytic residue [active] 762376003200 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 762376003201 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 762376003202 substrate binding site [chemical binding]; other site 762376003203 ATP binding site [chemical binding]; other site 762376003204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376003206 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376003207 putative effector binding pocket; other site 762376003208 dimerization interface [polypeptide binding]; other site 762376003209 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762376003210 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762376003211 active site 762376003212 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376003213 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376003214 Walker A/P-loop; other site 762376003215 ATP binding site [chemical binding]; other site 762376003216 Q-loop/lid; other site 762376003217 ABC transporter signature motif; other site 762376003218 Walker B; other site 762376003219 D-loop; other site 762376003220 H-loop/switch region; other site 762376003221 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376003222 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376003223 TM-ABC transporter signature motif; other site 762376003224 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376003225 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376003226 Walker A/P-loop; other site 762376003227 ATP binding site [chemical binding]; other site 762376003228 Q-loop/lid; other site 762376003229 ABC transporter signature motif; other site 762376003230 Walker B; other site 762376003231 D-loop; other site 762376003232 H-loop/switch region; other site 762376003233 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376003234 TM-ABC transporter signature motif; other site 762376003235 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376003236 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376003237 putative ligand binding site [chemical binding]; other site 762376003238 short chain dehydrogenase; Provisional; Region: PRK07577 762376003239 classical (c) SDRs; Region: SDR_c; cd05233 762376003240 NAD(P) binding site [chemical binding]; other site 762376003241 active site 762376003242 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 762376003243 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376003244 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376003245 short chain dehydrogenase; Validated; Region: PRK08264 762376003246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376003247 NAD(P) binding site [chemical binding]; other site 762376003248 active site 762376003249 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376003250 active site 762376003251 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 762376003252 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 762376003253 acyl-activating enzyme (AAE) consensus motif; other site 762376003254 putative AMP binding site [chemical binding]; other site 762376003255 putative active site [active] 762376003256 putative CoA binding site [chemical binding]; other site 762376003257 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 762376003258 inter-subunit interface; other site 762376003259 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 762376003260 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 762376003261 iron-sulfur cluster [ion binding]; other site 762376003262 [2Fe-2S] cluster binding site [ion binding]; other site 762376003263 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 762376003264 putative alpha subunit interface [polypeptide binding]; other site 762376003265 putative active site [active] 762376003266 putative substrate binding site [chemical binding]; other site 762376003267 Fe binding site [ion binding]; other site 762376003268 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 762376003269 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 762376003270 FMN-binding pocket [chemical binding]; other site 762376003271 flavin binding motif; other site 762376003272 phosphate binding motif [ion binding]; other site 762376003273 beta-alpha-beta structure motif; other site 762376003274 NAD binding pocket [chemical binding]; other site 762376003275 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376003276 catalytic loop [active] 762376003277 iron binding site [ion binding]; other site 762376003278 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 762376003279 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 762376003280 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 762376003281 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 762376003282 dimer interface [polypeptide binding]; other site 762376003283 PYR/PP interface [polypeptide binding]; other site 762376003284 TPP binding site [chemical binding]; other site 762376003285 substrate binding site [chemical binding]; other site 762376003286 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 762376003287 TPP-binding site; other site 762376003288 MarR family; Region: MarR_2; cl17246 762376003289 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376003290 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376003291 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376003292 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376003293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376003294 dimer interface [polypeptide binding]; other site 762376003295 conserved gate region; other site 762376003296 putative PBP binding loops; other site 762376003297 ABC-ATPase subunit interface; other site 762376003298 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762376003299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376003300 dimer interface [polypeptide binding]; other site 762376003301 conserved gate region; other site 762376003302 putative PBP binding loops; other site 762376003303 ABC-ATPase subunit interface; other site 762376003304 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376003305 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376003306 Walker A/P-loop; other site 762376003307 ATP binding site [chemical binding]; other site 762376003308 Q-loop/lid; other site 762376003309 ABC transporter signature motif; other site 762376003310 Walker B; other site 762376003311 D-loop; other site 762376003312 H-loop/switch region; other site 762376003313 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376003314 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376003315 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376003316 Walker A/P-loop; other site 762376003317 ATP binding site [chemical binding]; other site 762376003318 Q-loop/lid; other site 762376003319 ABC transporter signature motif; other site 762376003320 Walker B; other site 762376003321 D-loop; other site 762376003322 H-loop/switch region; other site 762376003323 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 762376003324 Cupin domain; Region: Cupin_2; cl17218 762376003325 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376003326 EamA-like transporter family; Region: EamA; pfam00892 762376003327 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376003328 EamA-like transporter family; Region: EamA; pfam00892 762376003329 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 762376003330 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376003331 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376003332 ABC transporter; Region: ABC_tran_2; pfam12848 762376003333 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376003334 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 762376003335 Isochorismatase family; Region: Isochorismatase; pfam00857 762376003336 catalytic triad [active] 762376003337 dimer interface [polypeptide binding]; other site 762376003338 conserved cis-peptide bond; other site 762376003339 cell division topological specificity factor MinE; Provisional; Region: PRK13989 762376003340 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 762376003341 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 762376003342 Switch I; other site 762376003343 Switch II; other site 762376003344 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 762376003345 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 762376003346 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 762376003347 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376003348 active site 762376003349 HIGH motif; other site 762376003350 nucleotide binding site [chemical binding]; other site 762376003351 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 762376003352 KMSKS motif; other site 762376003353 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 762376003354 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 762376003355 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 762376003356 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 762376003357 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 762376003358 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376003359 ATP binding site [chemical binding]; other site 762376003360 putative Mg++ binding site [ion binding]; other site 762376003361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376003362 nucleotide binding region [chemical binding]; other site 762376003363 ATP-binding site [chemical binding]; other site 762376003364 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 762376003365 HRDC domain; Region: HRDC; pfam00570 762376003366 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 762376003367 osmolarity response regulator; Provisional; Region: ompR; PRK09468 762376003368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376003369 active site 762376003370 phosphorylation site [posttranslational modification] 762376003371 intermolecular recognition site; other site 762376003372 dimerization interface [polypeptide binding]; other site 762376003373 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376003374 DNA binding site [nucleotide binding] 762376003375 sensor protein RstB; Provisional; Region: PRK10604 762376003376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376003377 ATP binding site [chemical binding]; other site 762376003378 Mg2+ binding site [ion binding]; other site 762376003379 G-X-G motif; other site 762376003380 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 762376003381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376003382 Walker A motif; other site 762376003383 ATP binding site [chemical binding]; other site 762376003384 Walker B motif; other site 762376003385 arginine finger; other site 762376003386 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 762376003387 serine racemase; Region: PLN02970 762376003388 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 762376003389 tetramer interface [polypeptide binding]; other site 762376003390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376003391 catalytic residue [active] 762376003392 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 762376003393 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 762376003394 putative NAD(P) binding site [chemical binding]; other site 762376003395 active site 762376003396 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 762376003397 RuvA N terminal domain; Region: RuvA_N; pfam01330 762376003398 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 762376003399 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 762376003400 active site 762376003401 putative DNA-binding cleft [nucleotide binding]; other site 762376003402 dimer interface [polypeptide binding]; other site 762376003403 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 762376003404 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 762376003405 purine monophosphate binding site [chemical binding]; other site 762376003406 dimer interface [polypeptide binding]; other site 762376003407 putative catalytic residues [active] 762376003408 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 762376003409 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 762376003410 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 762376003411 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 762376003412 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 762376003413 FMN binding site [chemical binding]; other site 762376003414 active site 762376003415 catalytic residues [active] 762376003416 substrate binding site [chemical binding]; other site 762376003417 hypothetical protein; Provisional; Region: PRK06996 762376003418 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 762376003419 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 762376003420 proline aminopeptidase P II; Provisional; Region: PRK10879 762376003421 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 762376003422 active site 762376003423 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 762376003424 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 762376003425 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 762376003426 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376003427 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 762376003428 Soluble P-type ATPase [General function prediction only]; Region: COG4087 762376003429 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 762376003430 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 762376003431 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 762376003432 trimer interface [polypeptide binding]; other site 762376003433 eyelet of channel; other site 762376003434 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 762376003435 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 762376003436 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 762376003437 DNA binding residues [nucleotide binding] 762376003438 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 762376003439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376003440 non-specific DNA binding site [nucleotide binding]; other site 762376003441 salt bridge; other site 762376003442 sequence-specific DNA binding site [nucleotide binding]; other site 762376003443 Cupin domain; Region: Cupin_2; pfam07883 762376003444 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 762376003445 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376003446 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 762376003447 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 762376003448 active site 762376003449 tetramer interface; other site 762376003450 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 762376003451 Peptidase family M48; Region: Peptidase_M48; cl12018 762376003452 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 762376003453 SnoaL-like domain; Region: SnoaL_3; pfam13474 762376003454 SnoaL-like domain; Region: SnoaL_2; pfam12680 762376003455 Zinc-finger domain; Region: zf-CHCC; cl01821 762376003456 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 762376003457 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 762376003458 homodimer interface [polypeptide binding]; other site 762376003459 substrate-cofactor binding pocket; other site 762376003460 catalytic residue [active] 762376003461 AzlC protein; Region: AzlC; pfam03591 762376003462 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 762376003463 helicase 45; Provisional; Region: PTZ00424 762376003464 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 762376003465 ATP binding site [chemical binding]; other site 762376003466 Mg++ binding site [ion binding]; other site 762376003467 motif III; other site 762376003468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376003469 nucleotide binding region [chemical binding]; other site 762376003470 ATP-binding site [chemical binding]; other site 762376003471 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762376003472 catalytic residues [active] 762376003473 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 762376003474 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 762376003475 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 762376003476 MPT binding site; other site 762376003477 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376003478 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376003479 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376003480 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376003481 Phasin protein; Region: Phasin_2; pfam09361 762376003482 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 762376003483 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 762376003484 quinone interaction residues [chemical binding]; other site 762376003485 active site 762376003486 catalytic residues [active] 762376003487 FMN binding site [chemical binding]; other site 762376003488 substrate binding site [chemical binding]; other site 762376003489 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 762376003490 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 762376003491 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 762376003492 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 762376003493 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 762376003494 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 762376003495 nudix motif; other site 762376003496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376003498 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376003499 putative effector binding pocket; other site 762376003500 dimerization interface [polypeptide binding]; other site 762376003501 Predicted membrane protein [Function unknown]; Region: COG2259 762376003502 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376003503 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 762376003504 putative kissing complex interaction region; other site 762376003505 putative RNA binding sites [nucleotide binding]; other site 762376003506 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 762376003507 ProQ/FINO family; Region: ProQ; pfam04352 762376003508 putative fimbrial protein TcfA; Provisional; Region: PRK15308 762376003509 putative fimbrial protein TcfA; Provisional; Region: PRK15308 762376003510 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 762376003511 putative fimbrial protein TcfA; Provisional; Region: PRK15308 762376003512 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 762376003513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376003514 dimer interface [polypeptide binding]; other site 762376003515 phosphorylation site [posttranslational modification] 762376003516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376003517 ATP binding site [chemical binding]; other site 762376003518 Mg2+ binding site [ion binding]; other site 762376003519 G-X-G motif; other site 762376003520 Response regulator receiver domain; Region: Response_reg; pfam00072 762376003521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376003522 active site 762376003523 phosphorylation site [posttranslational modification] 762376003524 intermolecular recognition site; other site 762376003525 dimerization interface [polypeptide binding]; other site 762376003526 Response regulator receiver domain; Region: Response_reg; pfam00072 762376003527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376003528 active site 762376003529 phosphorylation site [posttranslational modification] 762376003530 intermolecular recognition site; other site 762376003531 dimerization interface [polypeptide binding]; other site 762376003532 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376003533 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 762376003534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376003535 dimer interface [polypeptide binding]; other site 762376003536 phosphorylation site [posttranslational modification] 762376003537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376003538 ATP binding site [chemical binding]; other site 762376003539 Mg2+ binding site [ion binding]; other site 762376003540 G-X-G motif; other site 762376003541 Response regulator receiver domain; Region: Response_reg; pfam00072 762376003542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376003543 active site 762376003544 phosphorylation site [posttranslational modification] 762376003545 intermolecular recognition site; other site 762376003546 dimerization interface [polypeptide binding]; other site 762376003547 Autotransporter beta-domain; Region: Autotransporter; smart00869 762376003548 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 762376003549 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762376003550 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762376003551 Magnesium ion binding site [ion binding]; other site 762376003552 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 762376003553 ParB-like nuclease domain; Region: ParBc; pfam02195 762376003554 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 762376003555 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 762376003556 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 762376003557 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 762376003558 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762376003559 ssDNA binding site [nucleotide binding]; other site 762376003560 dimer interface [polypeptide binding]; other site 762376003561 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762376003562 DNA topoisomerase III; Provisional; Region: PRK07726 762376003563 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 762376003564 active site 762376003565 putative interdomain interaction site [polypeptide binding]; other site 762376003566 putative metal-binding site [ion binding]; other site 762376003567 putative nucleotide binding site [chemical binding]; other site 762376003568 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 762376003569 domain I; other site 762376003570 DNA binding groove [nucleotide binding] 762376003571 phosphate binding site [ion binding]; other site 762376003572 domain II; other site 762376003573 domain III; other site 762376003574 nucleotide binding site [chemical binding]; other site 762376003575 catalytic site [active] 762376003576 domain IV; other site 762376003577 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 762376003578 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 762376003579 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 762376003580 cofactor binding site; other site 762376003581 DNA binding site [nucleotide binding] 762376003582 substrate interaction site [chemical binding]; other site 762376003583 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 762376003584 putative transcriptional regulator MerR; Provisional; Region: PRK13752 762376003585 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 762376003586 DNA binding residues [nucleotide binding] 762376003587 dimer interface [polypeptide binding]; other site 762376003588 mercury binding site [ion binding]; other site 762376003589 putative mercuric transport protein; Provisional; Region: PRK13751 762376003590 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376003591 metal-binding site [ion binding] 762376003592 putative mercuric reductase; Provisional; Region: PRK13748 762376003593 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376003594 metal-binding site [ion binding] 762376003595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376003596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376003597 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376003598 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 762376003599 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 762376003600 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 762376003601 Domain of unknown function (DUF932); Region: DUF932; pfam06067 762376003602 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 762376003603 Methyltransferase domain; Region: Methyltransf_26; pfam13659 762376003604 S-adenosylmethionine binding site [chemical binding]; other site 762376003605 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762376003606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376003607 nucleotide binding region [chemical binding]; other site 762376003608 ATP-binding site [chemical binding]; other site 762376003609 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 762376003610 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762376003611 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 762376003612 ArsC family; Region: ArsC; pfam03960 762376003613 catalytic residues [active] 762376003614 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 762376003615 arsenical-resistance protein; Region: acr3; TIGR00832 762376003616 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762376003617 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 762376003618 active site 762376003619 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376003620 dimerization interface [polypeptide binding]; other site 762376003621 putative DNA binding site [nucleotide binding]; other site 762376003622 putative Zn2+ binding site [ion binding]; other site 762376003623 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 762376003624 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 762376003625 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762376003626 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376003627 catalytic residue [active] 762376003628 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 762376003629 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 762376003630 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 762376003631 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 762376003632 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 762376003633 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 762376003634 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 762376003635 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 762376003636 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 762376003637 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 762376003638 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 762376003639 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 762376003640 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 762376003641 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 762376003642 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 762376003643 Thioredoxin; Region: Thioredoxin_4; cl17273 762376003644 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 762376003645 MPN+ (JAMM) motif; other site 762376003646 Zinc-binding site [ion binding]; other site 762376003647 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 762376003648 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 762376003649 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 762376003650 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 762376003651 Protein of unknown function (DUF3742); Region: DUF3742; pfam12553 762376003652 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 762376003653 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 762376003654 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 762376003655 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 762376003656 Putative helicase; Region: TraI_2; pfam07514 762376003657 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 762376003658 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 762376003659 sensor kinase CusS; Provisional; Region: PRK09835 762376003660 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376003661 dimerization interface [polypeptide binding]; other site 762376003662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376003663 dimer interface [polypeptide binding]; other site 762376003664 phosphorylation site [posttranslational modification] 762376003665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376003666 ATP binding site [chemical binding]; other site 762376003667 Mg2+ binding site [ion binding]; other site 762376003668 G-X-G motif; other site 762376003669 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 762376003670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376003671 active site 762376003672 phosphorylation site [posttranslational modification] 762376003673 intermolecular recognition site; other site 762376003674 dimerization interface [polypeptide binding]; other site 762376003675 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376003676 DNA binding site [nucleotide binding] 762376003677 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 762376003678 Multicopper oxidase; Region: Cu-oxidase; pfam00394 762376003679 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 762376003680 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 762376003681 Predicted metal-binding protein [General function prediction only]; Region: COG3019 762376003682 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 762376003683 YHS domain; Region: YHS; pfam04945 762376003684 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 762376003685 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376003686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376003687 motif II; other site 762376003688 CopC domain; Region: CopC; pfam04234 762376003689 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 762376003690 Copper resistance protein K; Region: CopK; pfam11525 762376003691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376003693 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376003694 dimerization interface [polypeptide binding]; other site 762376003695 substrate binding pocket [chemical binding]; other site 762376003696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376003697 non-specific DNA binding site [nucleotide binding]; other site 762376003698 salt bridge; other site 762376003699 sequence-specific DNA binding site [nucleotide binding]; other site 762376003700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003702 dimerization interface [polypeptide binding]; other site 762376003703 Transposase domain (DUF772); Region: DUF772; pfam05598 762376003704 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 762376003705 DDE superfamily endonuclease; Region: DDE_4; cl17710 762376003706 Outer membrane efflux protein; Region: OEP; pfam02321 762376003707 Outer membrane efflux protein; Region: OEP; pfam02321 762376003708 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 762376003709 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376003710 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 762376003711 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 762376003712 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376003713 integrase; Provisional; Region: PRK09692 762376003714 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 762376003715 active site 762376003716 Int/Topo IB signature motif; other site 762376003717 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 762376003718 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376003719 catalytic loop [active] 762376003720 iron binding site [ion binding]; other site 762376003721 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 762376003722 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 762376003723 Iron-sulfur protein interface; other site 762376003724 proximal heme binding site [chemical binding]; other site 762376003725 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 762376003726 L-aspartate oxidase; Provisional; Region: PRK06175 762376003727 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 762376003728 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 762376003729 Fumarase C-terminus; Region: Fumerase_C; cl00795 762376003730 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 762376003731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376003733 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 762376003734 putative dimerization interface [polypeptide binding]; other site 762376003735 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376003736 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376003737 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 762376003738 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 762376003739 tetrameric interface [polypeptide binding]; other site 762376003740 NAD binding site [chemical binding]; other site 762376003741 catalytic residues [active] 762376003742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376003744 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376003745 putative effector binding pocket; other site 762376003746 dimerization interface [polypeptide binding]; other site 762376003747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376003748 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 762376003749 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376003750 PYR/PP interface [polypeptide binding]; other site 762376003751 dimer interface [polypeptide binding]; other site 762376003752 TPP binding site [chemical binding]; other site 762376003753 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376003754 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 762376003755 TPP-binding site [chemical binding]; other site 762376003756 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 762376003757 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 762376003758 tetramer interface [polypeptide binding]; other site 762376003759 heme binding pocket [chemical binding]; other site 762376003760 NADPH binding site [chemical binding]; other site 762376003761 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 762376003762 FAD binding domain; Region: FAD_binding_4; pfam01565 762376003763 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 762376003764 dihydrodipicolinate reductase; Provisional; Region: PRK00048 762376003765 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 762376003766 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 762376003767 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 762376003768 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 762376003769 ferric uptake regulator; Provisional; Region: fur; PRK09462 762376003770 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762376003771 metal binding site 2 [ion binding]; metal-binding site 762376003772 putative DNA binding helix; other site 762376003773 metal binding site 1 [ion binding]; metal-binding site 762376003774 dimer interface [polypeptide binding]; other site 762376003775 structural Zn2+ binding site [ion binding]; other site 762376003776 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 762376003777 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 762376003778 Walker A/P-loop; other site 762376003779 ATP binding site [chemical binding]; other site 762376003780 Q-loop/lid; other site 762376003781 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 762376003782 ABC transporter signature motif; other site 762376003783 Walker B; other site 762376003784 D-loop; other site 762376003785 H-loop/switch region; other site 762376003786 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 762376003787 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 762376003788 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 762376003789 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 762376003790 ferrochelatase; Reviewed; Region: hemH; PRK00035 762376003791 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 762376003792 C-terminal domain interface [polypeptide binding]; other site 762376003793 active site 762376003794 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 762376003795 active site 762376003796 N-terminal domain interface [polypeptide binding]; other site 762376003797 GrpE; Region: GrpE; pfam01025 762376003798 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 762376003799 dimer interface [polypeptide binding]; other site 762376003800 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 762376003801 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762376003802 catalytic residues [active] 762376003803 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 762376003804 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 762376003805 nucleotide binding site [chemical binding]; other site 762376003806 chaperone protein DnaJ; Provisional; Region: PRK10767 762376003807 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 762376003808 HSP70 interaction site [polypeptide binding]; other site 762376003809 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 762376003810 Zn binding sites [ion binding]; other site 762376003811 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 762376003812 dimer interface [polypeptide binding]; other site 762376003813 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762376003814 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 762376003815 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762376003816 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762376003817 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762376003818 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762376003819 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 762376003820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376003821 Coenzyme A binding pocket [chemical binding]; other site 762376003822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 762376003823 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762376003824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376003825 Walker A motif; other site 762376003826 ATP binding site [chemical binding]; other site 762376003827 Walker B motif; other site 762376003828 arginine finger; other site 762376003829 Cytochrome c553 [Energy production and conversion]; Region: COG2863 762376003830 Cytochrome c553 [Energy production and conversion]; Region: COG2863 762376003831 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 762376003832 isocitrate dehydrogenase; Validated; Region: PRK07362 762376003833 isocitrate dehydrogenase; Reviewed; Region: PRK07006 762376003834 O-Antigen ligase; Region: Wzy_C; pfam04932 762376003835 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 762376003836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376003837 dimerization interface [polypeptide binding]; other site 762376003838 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762376003839 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376003840 dimer interface [polypeptide binding]; other site 762376003841 putative CheW interface [polypeptide binding]; other site 762376003842 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376003843 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762376003844 dimer interface [polypeptide binding]; other site 762376003845 active site 762376003846 catalytic residue [active] 762376003847 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694 762376003848 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 762376003849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376003850 active site 762376003851 phosphorylation site [posttranslational modification] 762376003852 intermolecular recognition site; other site 762376003853 dimerization interface [polypeptide binding]; other site 762376003854 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376003855 DNA binding site [nucleotide binding] 762376003856 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 762376003857 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 762376003858 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 762376003859 Ligand Binding Site [chemical binding]; other site 762376003860 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 762376003861 GAF domain; Region: GAF_3; pfam13492 762376003862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376003863 dimer interface [polypeptide binding]; other site 762376003864 phosphorylation site [posttranslational modification] 762376003865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376003866 ATP binding site [chemical binding]; other site 762376003867 Mg2+ binding site [ion binding]; other site 762376003868 G-X-G motif; other site 762376003869 K+-transporting ATPase, c chain; Region: KdpC; cl00944 762376003870 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 762376003871 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376003872 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 762376003873 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 762376003874 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 762376003875 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 762376003876 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 762376003877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 762376003878 Smr domain; Region: Smr; pfam01713 762376003879 thioredoxin reductase; Provisional; Region: PRK10262 762376003880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376003881 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376003882 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 762376003883 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 762376003884 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 762376003885 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 762376003886 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 762376003887 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376003888 homotrimer interaction site [polypeptide binding]; other site 762376003889 putative active site [active] 762376003890 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 762376003891 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 762376003892 active site 762376003893 putative substrate binding pocket [chemical binding]; other site 762376003894 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376003895 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 762376003896 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 762376003897 putative active site [active] 762376003898 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 762376003899 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376003900 Walker A/P-loop; other site 762376003901 ATP binding site [chemical binding]; other site 762376003902 Q-loop/lid; other site 762376003903 ABC transporter signature motif; other site 762376003904 Walker B; other site 762376003905 D-loop; other site 762376003906 H-loop/switch region; other site 762376003907 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376003908 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376003909 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376003910 Walker A/P-loop; other site 762376003911 ATP binding site [chemical binding]; other site 762376003912 Q-loop/lid; other site 762376003913 ABC transporter signature motif; other site 762376003914 Walker B; other site 762376003915 D-loop; other site 762376003916 H-loop/switch region; other site 762376003917 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376003918 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376003919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376003920 dimer interface [polypeptide binding]; other site 762376003921 conserved gate region; other site 762376003922 putative PBP binding loops; other site 762376003923 ABC-ATPase subunit interface; other site 762376003924 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376003925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376003926 dimer interface [polypeptide binding]; other site 762376003927 conserved gate region; other site 762376003928 putative PBP binding loops; other site 762376003929 ABC-ATPase subunit interface; other site 762376003930 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376003931 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376003932 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 762376003933 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 762376003934 dimer interface [polypeptide binding]; other site 762376003935 active site 762376003936 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376003937 substrate binding site [chemical binding]; other site 762376003938 catalytic residue [active] 762376003939 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376003940 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 762376003941 putative active site [active] 762376003942 catalytic triad [active] 762376003943 putative dimer interface [polypeptide binding]; other site 762376003944 recombination factor protein RarA; Reviewed; Region: PRK13342 762376003945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376003946 Walker A motif; other site 762376003947 ATP binding site [chemical binding]; other site 762376003948 Walker B motif; other site 762376003949 arginine finger; other site 762376003950 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 762376003951 seryl-tRNA synthetase; Provisional; Region: PRK05431 762376003952 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 762376003953 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 762376003954 dimer interface [polypeptide binding]; other site 762376003955 active site 762376003956 motif 1; other site 762376003957 motif 2; other site 762376003958 motif 3; other site 762376003959 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 762376003960 cytosine deaminase; Provisional; Region: PRK05985 762376003961 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 762376003962 active site 762376003963 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376003964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376003965 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 762376003966 putative dimerization interface [polypeptide binding]; other site 762376003967 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 762376003968 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 762376003969 active site pocket [active] 762376003970 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376003971 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 762376003972 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 762376003973 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376003974 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 762376003975 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 762376003976 trimer interface [polypeptide binding]; other site 762376003977 eyelet of channel; other site 762376003978 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376003979 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376003980 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376003981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376003982 putative substrate translocation pore; other site 762376003983 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376003984 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 762376003985 putative active site [active] 762376003986 catalytic triad [active] 762376003987 putative dimer interface [polypeptide binding]; other site 762376003988 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 762376003989 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 762376003990 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 762376003991 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 762376003992 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 762376003993 NAD binding site [chemical binding]; other site 762376003994 homotetramer interface [polypeptide binding]; other site 762376003995 homodimer interface [polypeptide binding]; other site 762376003996 substrate binding site [chemical binding]; other site 762376003997 active site 762376003998 hypothetical protein; Validated; Region: PRK02101 762376003999 Predicted membrane protein [Function unknown]; Region: COG1289 762376004000 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 762376004001 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 762376004002 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 762376004003 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376004004 PYR/PP interface [polypeptide binding]; other site 762376004005 dimer interface [polypeptide binding]; other site 762376004006 TPP binding site [chemical binding]; other site 762376004007 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376004008 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 762376004009 TPP-binding site [chemical binding]; other site 762376004010 dimer interface [polypeptide binding]; other site 762376004011 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 762376004012 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 762376004013 putative valine binding site [chemical binding]; other site 762376004014 dimer interface [polypeptide binding]; other site 762376004015 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 762376004016 ketol-acid reductoisomerase; Provisional; Region: PRK05479 762376004017 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 762376004018 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 762376004019 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 762376004020 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 762376004021 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 762376004022 16S/18S rRNA binding site [nucleotide binding]; other site 762376004023 S13e-L30e interaction site [polypeptide binding]; other site 762376004024 25S rRNA binding site [nucleotide binding]; other site 762376004025 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 762376004026 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 762376004027 RNase E interface [polypeptide binding]; other site 762376004028 trimer interface [polypeptide binding]; other site 762376004029 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 762376004030 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 762376004031 RNase E interface [polypeptide binding]; other site 762376004032 trimer interface [polypeptide binding]; other site 762376004033 active site 762376004034 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 762376004035 putative nucleic acid binding region [nucleotide binding]; other site 762376004036 G-X-X-G motif; other site 762376004037 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 762376004038 RNA binding site [nucleotide binding]; other site 762376004039 domain interface; other site 762376004040 threonine dehydratase; Provisional; Region: PRK07334 762376004041 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 762376004042 tetramer interface [polypeptide binding]; other site 762376004043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376004044 catalytic residue [active] 762376004045 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 762376004046 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376004047 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376004048 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 762376004049 putative N-terminal domain interface [polypeptide binding]; other site 762376004050 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 762376004051 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376004052 putative active site [active] 762376004053 catalytic triad [active] 762376004054 putative dimer interface [polypeptide binding]; other site 762376004055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376004056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376004057 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 762376004058 putative substrate binding pocket [chemical binding]; other site 762376004059 putative dimerization interface [polypeptide binding]; other site 762376004060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762376004061 binding surface 762376004062 TPR motif; other site 762376004063 Tetratricopeptide repeat; Region: TPR_12; pfam13424 762376004064 TPR repeat; Region: TPR_11; pfam13414 762376004065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762376004066 binding surface 762376004067 TPR motif; other site 762376004068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762376004069 binding surface 762376004070 TPR motif; other site 762376004071 TPR repeat; Region: TPR_11; pfam13414 762376004072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 762376004073 binding surface 762376004074 RDD family; Region: RDD; pfam06271 762376004075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376004076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376004077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004078 dimerization interface [polypeptide binding]; other site 762376004079 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376004080 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376004081 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376004082 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 762376004083 active site 762376004084 catalytic residues [active] 762376004085 metal binding site [ion binding]; metal-binding site 762376004086 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376004087 Ligand Binding Site [chemical binding]; other site 762376004088 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 762376004089 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 762376004090 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 762376004091 NAD(P) binding site [chemical binding]; other site 762376004092 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 762376004093 triosephosphate isomerase; Provisional; Region: PRK14567 762376004094 substrate binding site [chemical binding]; other site 762376004095 dimer interface [polypeptide binding]; other site 762376004096 catalytic triad [active] 762376004097 Preprotein translocase SecG subunit; Region: SecG; pfam03840 762376004098 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376004099 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 762376004100 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 762376004101 putative active site [active] 762376004102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376004103 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 762376004104 active site 762376004105 motif I; other site 762376004106 motif II; other site 762376004107 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 762376004108 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 762376004109 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 762376004110 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 762376004111 Walker A/P-loop; other site 762376004112 ATP binding site [chemical binding]; other site 762376004113 Q-loop/lid; other site 762376004114 ABC transporter signature motif; other site 762376004115 Walker B; other site 762376004116 D-loop; other site 762376004117 H-loop/switch region; other site 762376004118 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 762376004119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004120 dimer interface [polypeptide binding]; other site 762376004121 conserved gate region; other site 762376004122 putative PBP binding loops; other site 762376004123 ABC-ATPase subunit interface; other site 762376004124 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 762376004125 Phosphoesterase family; Region: Phosphoesterase; pfam04185 762376004126 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376004127 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376004128 YadA-like C-terminal region; Region: YadA; pfam03895 762376004129 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376004130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376004131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004132 dimerization interface [polypeptide binding]; other site 762376004133 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 762376004134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 762376004135 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 762376004136 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 762376004137 phosphate binding site [ion binding]; other site 762376004138 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376004139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376004140 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 762376004141 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376004142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376004143 Walker A/P-loop; other site 762376004144 ATP binding site [chemical binding]; other site 762376004145 Q-loop/lid; other site 762376004146 ABC transporter signature motif; other site 762376004147 Walker B; other site 762376004148 D-loop; other site 762376004149 H-loop/switch region; other site 762376004150 TOBE domain; Region: TOBE_2; pfam08402 762376004151 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 762376004152 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 762376004153 NAD(P) binding site [chemical binding]; other site 762376004154 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376004155 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 762376004156 putative C-terminal domain interface [polypeptide binding]; other site 762376004157 putative GSH binding site (G-site) [chemical binding]; other site 762376004158 putative dimer interface [polypeptide binding]; other site 762376004159 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 762376004160 dimer interface [polypeptide binding]; other site 762376004161 N-terminal domain interface [polypeptide binding]; other site 762376004162 putative substrate binding pocket (H-site) [chemical binding]; other site 762376004163 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 762376004164 Dehydroquinase class II; Region: DHquinase_II; pfam01220 762376004165 trimer interface [polypeptide binding]; other site 762376004166 active site 762376004167 dimer interface [polypeptide binding]; other site 762376004168 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 762376004169 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 762376004170 putative ligand binding site [chemical binding]; other site 762376004171 NAD binding site [chemical binding]; other site 762376004172 dimerization interface [polypeptide binding]; other site 762376004173 catalytic site [active] 762376004174 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 762376004175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004176 dimer interface [polypeptide binding]; other site 762376004177 conserved gate region; other site 762376004178 putative PBP binding loops; other site 762376004179 ABC-ATPase subunit interface; other site 762376004180 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 762376004181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004182 putative PBP binding loops; other site 762376004183 dimer interface [polypeptide binding]; other site 762376004184 ABC-ATPase subunit interface; other site 762376004185 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 762376004186 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 762376004187 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376004188 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376004189 Walker A/P-loop; other site 762376004190 ATP binding site [chemical binding]; other site 762376004191 Q-loop/lid; other site 762376004192 ABC transporter signature motif; other site 762376004193 Walker B; other site 762376004194 D-loop; other site 762376004195 H-loop/switch region; other site 762376004196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004197 dimer interface [polypeptide binding]; other site 762376004198 conserved gate region; other site 762376004199 putative PBP binding loops; other site 762376004200 ABC-ATPase subunit interface; other site 762376004201 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376004202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004203 dimer interface [polypeptide binding]; other site 762376004204 conserved gate region; other site 762376004205 putative PBP binding loops; other site 762376004206 ABC-ATPase subunit interface; other site 762376004207 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376004208 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376004209 substrate binding pocket [chemical binding]; other site 762376004210 membrane-bound complex binding site; other site 762376004211 hinge residues; other site 762376004212 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376004213 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376004214 homotrimer interaction site [polypeptide binding]; other site 762376004215 putative active site [active] 762376004216 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 762376004217 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376004218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376004219 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 762376004220 putative substrate binding pocket [chemical binding]; other site 762376004221 dimerization interface [polypeptide binding]; other site 762376004222 acetylornithine deacetylase; Provisional; Region: PRK07522 762376004223 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 762376004224 metal binding site [ion binding]; metal-binding site 762376004225 putative dimer interface [polypeptide binding]; other site 762376004226 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 762376004227 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 762376004228 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 762376004229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376004230 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376004231 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376004232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376004233 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376004234 substrate binding site [chemical binding]; other site 762376004235 oxyanion hole (OAH) forming residues; other site 762376004236 trimer interface [polypeptide binding]; other site 762376004237 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762376004238 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 762376004239 NAD(P) binding site [chemical binding]; other site 762376004240 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376004241 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376004242 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376004243 active site 762376004244 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376004245 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376004246 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376004247 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376004248 non-specific DNA binding site [nucleotide binding]; other site 762376004249 salt bridge; other site 762376004250 sequence-specific DNA binding site [nucleotide binding]; other site 762376004251 Cupin domain; Region: Cupin_2; pfam07883 762376004252 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 762376004253 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 762376004254 active site 762376004255 putative substrate binding pocket [chemical binding]; other site 762376004256 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376004257 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376004258 Walker A/P-loop; other site 762376004259 ATP binding site [chemical binding]; other site 762376004260 Q-loop/lid; other site 762376004261 ABC transporter signature motif; other site 762376004262 Walker B; other site 762376004263 D-loop; other site 762376004264 H-loop/switch region; other site 762376004265 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 762376004266 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376004267 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376004268 Walker A/P-loop; other site 762376004269 ATP binding site [chemical binding]; other site 762376004270 Q-loop/lid; other site 762376004271 ABC transporter signature motif; other site 762376004272 Walker B; other site 762376004273 D-loop; other site 762376004274 H-loop/switch region; other site 762376004275 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376004276 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762376004277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004278 dimer interface [polypeptide binding]; other site 762376004279 conserved gate region; other site 762376004280 putative PBP binding loops; other site 762376004281 ABC-ATPase subunit interface; other site 762376004282 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376004283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004284 dimer interface [polypeptide binding]; other site 762376004285 conserved gate region; other site 762376004286 putative PBP binding loops; other site 762376004287 ABC-ATPase subunit interface; other site 762376004288 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376004289 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376004290 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376004291 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376004292 MlrC C-terminus; Region: MlrC_C; pfam07171 762376004293 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376004294 homotrimer interaction site [polypeptide binding]; other site 762376004295 putative active site [active] 762376004296 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376004297 hydroxyglutarate oxidase; Provisional; Region: PRK11728 762376004298 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 762376004299 dimer interface [polypeptide binding]; other site 762376004300 putative tRNA-binding site [nucleotide binding]; other site 762376004301 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 762376004302 dimer interface [polypeptide binding]; other site 762376004303 FMN binding site [chemical binding]; other site 762376004304 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 762376004305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 762376004306 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762376004307 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 762376004308 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 762376004309 META domain; Region: META; pfam03724 762376004310 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 762376004311 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376004312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376004313 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376004314 DNA binding residues [nucleotide binding] 762376004315 fec operon regulator FecR; Reviewed; Region: PRK09774 762376004316 FecR protein; Region: FecR; pfam04773 762376004317 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376004318 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376004319 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376004320 N-terminal plug; other site 762376004321 ligand-binding site [chemical binding]; other site 762376004322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 762376004323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376004324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376004325 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 762376004326 putative dimerization interface [polypeptide binding]; other site 762376004327 Sulfatase; Region: Sulfatase; cl17466 762376004328 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376004329 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376004330 Predicted membrane protein [Function unknown]; Region: COG1971 762376004331 Domain of unknown function DUF; Region: DUF204; pfam02659 762376004332 Domain of unknown function DUF; Region: DUF204; pfam02659 762376004333 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 762376004334 heme-binding site [chemical binding]; other site 762376004335 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 762376004336 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376004337 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376004338 ligand binding site [chemical binding]; other site 762376004339 flexible hinge region; other site 762376004340 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 762376004341 putative switch regulator; other site 762376004342 non-specific DNA interactions [nucleotide binding]; other site 762376004343 DNA binding site [nucleotide binding] 762376004344 sequence specific DNA binding site [nucleotide binding]; other site 762376004345 putative cAMP binding site [chemical binding]; other site 762376004346 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 762376004347 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 762376004348 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376004349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 762376004350 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 762376004351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376004352 Walker A/P-loop; other site 762376004353 ATP binding site [chemical binding]; other site 762376004354 Q-loop/lid; other site 762376004355 ABC transporter signature motif; other site 762376004356 Walker B; other site 762376004357 D-loop; other site 762376004358 H-loop/switch region; other site 762376004359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 762376004360 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762376004361 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376004362 N-terminal plug; other site 762376004363 ligand-binding site [chemical binding]; other site 762376004364 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376004365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376004366 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376004367 dimerization interface [polypeptide binding]; other site 762376004368 substrate binding pocket [chemical binding]; other site 762376004369 D-serine dehydratase; Provisional; Region: PRK02991 762376004370 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 762376004371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376004372 catalytic residue [active] 762376004373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376004374 D-galactonate transporter; Region: 2A0114; TIGR00893 762376004375 putative substrate translocation pore; other site 762376004376 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376004377 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376004378 MlrC C-terminus; Region: MlrC_C; pfam07171 762376004379 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 762376004380 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 762376004381 CGNR zinc finger; Region: zf-CGNR; pfam11706 762376004382 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762376004383 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376004384 PAS fold; Region: PAS_3; pfam08447 762376004385 putative active site [active] 762376004386 heme pocket [chemical binding]; other site 762376004387 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376004388 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376004389 metal binding site [ion binding]; metal-binding site 762376004390 active site 762376004391 I-site; other site 762376004392 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 762376004393 hydrophobic ligand binding site; other site 762376004394 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376004395 EamA-like transporter family; Region: EamA; pfam00892 762376004396 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376004397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376004398 DNA-binding site [nucleotide binding]; DNA binding site 762376004399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376004400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376004401 homodimer interface [polypeptide binding]; other site 762376004402 catalytic residue [active] 762376004403 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376004404 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376004405 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376004406 N-terminal plug; other site 762376004407 ligand-binding site [chemical binding]; other site 762376004408 fec operon regulator FecR; Reviewed; Region: PRK09774 762376004409 FecR protein; Region: FecR; pfam04773 762376004410 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376004411 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376004412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376004413 DNA binding residues [nucleotide binding] 762376004414 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376004415 FecR protein; Region: FecR; pfam04773 762376004416 RNA polymerase sigma factor; Provisional; Region: PRK12529 762376004417 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376004418 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376004419 DNA binding residues [nucleotide binding] 762376004420 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376004421 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 762376004422 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762376004423 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762376004424 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 762376004425 heme binding pocket [chemical binding]; other site 762376004426 heme ligand [chemical binding]; other site 762376004427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 762376004428 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376004429 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376004430 Walker A/P-loop; other site 762376004431 ATP binding site [chemical binding]; other site 762376004432 Q-loop/lid; other site 762376004433 ABC transporter signature motif; other site 762376004434 Walker B; other site 762376004435 D-loop; other site 762376004436 H-loop/switch region; other site 762376004437 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376004438 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376004439 Walker A/P-loop; other site 762376004440 ATP binding site [chemical binding]; other site 762376004441 Q-loop/lid; other site 762376004442 ABC transporter signature motif; other site 762376004443 Walker B; other site 762376004444 D-loop; other site 762376004445 H-loop/switch region; other site 762376004446 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376004447 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376004448 TM-ABC transporter signature motif; other site 762376004449 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376004450 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376004451 TM-ABC transporter signature motif; other site 762376004452 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376004453 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376004454 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 762376004455 Beta-lactamase; Region: Beta-lactamase; pfam00144 762376004456 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 762376004457 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 762376004458 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376004459 acyl-activating enzyme (AAE) consensus motif; other site 762376004460 AMP binding site [chemical binding]; other site 762376004461 active site 762376004462 CoA binding site [chemical binding]; other site 762376004463 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 762376004464 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 762376004465 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376004466 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 762376004467 DNA binding residues [nucleotide binding] 762376004468 dimerization interface [polypeptide binding]; other site 762376004469 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 762376004470 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 762376004471 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 762376004472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376004473 dimer interface [polypeptide binding]; other site 762376004474 phosphorylation site [posttranslational modification] 762376004475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376004476 ATP binding site [chemical binding]; other site 762376004477 Mg2+ binding site [ion binding]; other site 762376004478 G-X-G motif; other site 762376004479 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 762376004480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376004481 active site 762376004482 phosphorylation site [posttranslational modification] 762376004483 intermolecular recognition site; other site 762376004484 dimerization interface [polypeptide binding]; other site 762376004485 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376004486 DNA binding site [nucleotide binding] 762376004487 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 762376004488 Citrate transporter; Region: CitMHS; pfam03600 762376004489 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 762376004490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376004491 NAD(P) binding site [chemical binding]; other site 762376004492 active site 762376004493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376004494 non-specific DNA binding site [nucleotide binding]; other site 762376004495 salt bridge; other site 762376004496 sequence-specific DNA binding site [nucleotide binding]; other site 762376004497 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 762376004498 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376004499 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376004500 Sulfatase; Region: Sulfatase; pfam00884 762376004501 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376004502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376004503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004504 dimerization interface [polypeptide binding]; other site 762376004505 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376004506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004507 dimer interface [polypeptide binding]; other site 762376004508 conserved gate region; other site 762376004509 putative PBP binding loops; other site 762376004510 ABC-ATPase subunit interface; other site 762376004511 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376004512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004513 dimer interface [polypeptide binding]; other site 762376004514 conserved gate region; other site 762376004515 putative PBP binding loops; other site 762376004516 ABC-ATPase subunit interface; other site 762376004517 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 762376004518 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376004519 Walker A/P-loop; other site 762376004520 ATP binding site [chemical binding]; other site 762376004521 Q-loop/lid; other site 762376004522 ABC transporter signature motif; other site 762376004523 Walker B; other site 762376004524 D-loop; other site 762376004525 H-loop/switch region; other site 762376004526 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376004527 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376004528 Walker A/P-loop; other site 762376004529 ATP binding site [chemical binding]; other site 762376004530 Q-loop/lid; other site 762376004531 ABC transporter signature motif; other site 762376004532 Walker B; other site 762376004533 D-loop; other site 762376004534 H-loop/switch region; other site 762376004535 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376004536 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376004537 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376004538 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376004539 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376004540 MlrC C-terminus; Region: MlrC_C; pfam07171 762376004541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376004542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376004543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376004544 dimerization interface [polypeptide binding]; other site 762376004545 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376004546 classical (c) SDRs; Region: SDR_c; cd05233 762376004547 NAD(P) binding site [chemical binding]; other site 762376004548 active site 762376004549 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376004550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004551 dimer interface [polypeptide binding]; other site 762376004552 conserved gate region; other site 762376004553 putative PBP binding loops; other site 762376004554 ABC-ATPase subunit interface; other site 762376004555 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376004556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004557 dimer interface [polypeptide binding]; other site 762376004558 conserved gate region; other site 762376004559 putative PBP binding loops; other site 762376004560 ABC-ATPase subunit interface; other site 762376004561 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376004562 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762376004563 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762376004564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 762376004565 DNA binding site [nucleotide binding] 762376004566 domain linker motif; other site 762376004567 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 762376004568 putative dimerization interface [polypeptide binding]; other site 762376004569 putative ligand binding site [chemical binding]; other site 762376004570 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 762376004571 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 762376004572 histidinol dehydrogenase; Region: hisD; TIGR00069 762376004573 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 762376004574 NAD binding site [chemical binding]; other site 762376004575 dimerization interface [polypeptide binding]; other site 762376004576 product binding site; other site 762376004577 substrate binding site [chemical binding]; other site 762376004578 zinc binding site [ion binding]; other site 762376004579 catalytic residues [active] 762376004580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376004581 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376004582 NAD(P) binding site [chemical binding]; other site 762376004583 active site 762376004584 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 762376004585 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762376004586 NAD(P) binding site [chemical binding]; other site 762376004587 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376004588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004589 dimer interface [polypeptide binding]; other site 762376004590 conserved gate region; other site 762376004591 putative PBP binding loops; other site 762376004592 ABC-ATPase subunit interface; other site 762376004593 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376004594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004595 dimer interface [polypeptide binding]; other site 762376004596 conserved gate region; other site 762376004597 putative PBP binding loops; other site 762376004598 ABC-ATPase subunit interface; other site 762376004599 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 762376004600 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 762376004601 substrate binding pocket [chemical binding]; other site 762376004602 membrane-bound complex binding site; other site 762376004603 hinge residues; other site 762376004604 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376004605 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762376004606 Walker A/P-loop; other site 762376004607 ATP binding site [chemical binding]; other site 762376004608 Q-loop/lid; other site 762376004609 ABC transporter signature motif; other site 762376004610 Walker B; other site 762376004611 D-loop; other site 762376004612 H-loop/switch region; other site 762376004613 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 762376004614 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762376004615 tetramer interface [polypeptide binding]; other site 762376004616 TPP-binding site [chemical binding]; other site 762376004617 heterodimer interface [polypeptide binding]; other site 762376004618 phosphorylation loop region [posttranslational modification] 762376004619 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762376004620 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762376004621 alpha subunit interface [polypeptide binding]; other site 762376004622 TPP binding site [chemical binding]; other site 762376004623 heterodimer interface [polypeptide binding]; other site 762376004624 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376004625 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376004626 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 762376004627 active site 762376004628 metal binding site [ion binding]; metal-binding site 762376004629 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376004630 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 762376004631 E3 interaction surface; other site 762376004632 lipoyl attachment site [posttranslational modification]; other site 762376004633 e3 binding domain; Region: E3_binding; pfam02817 762376004634 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762376004635 DNA-binding site [nucleotide binding]; DNA binding site 762376004636 RNA-binding motif; other site 762376004637 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 762376004638 GAF domain; Region: GAF; pfam01590 762376004639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376004640 Walker A motif; other site 762376004641 ATP binding site [chemical binding]; other site 762376004642 Walker B motif; other site 762376004643 arginine finger; other site 762376004644 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 762376004645 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 762376004646 Hemerythrin-like domain; Region: Hr-like; cd12108 762376004647 Fe binding site [ion binding]; other site 762376004648 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 762376004649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 762376004650 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 762376004651 Protein of unknown function (DUF808); Region: DUF808; pfam05661 762376004652 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 762376004653 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376004654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004655 putative PBP binding loops; other site 762376004656 dimer interface [polypeptide binding]; other site 762376004657 ABC-ATPase subunit interface; other site 762376004658 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376004659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376004660 dimer interface [polypeptide binding]; other site 762376004661 conserved gate region; other site 762376004662 putative PBP binding loops; other site 762376004663 ABC-ATPase subunit interface; other site 762376004664 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376004665 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376004666 Walker A/P-loop; other site 762376004667 ATP binding site [chemical binding]; other site 762376004668 Q-loop/lid; other site 762376004669 ABC transporter signature motif; other site 762376004670 Walker B; other site 762376004671 D-loop; other site 762376004672 H-loop/switch region; other site 762376004673 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376004674 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376004675 Walker A/P-loop; other site 762376004676 ATP binding site [chemical binding]; other site 762376004677 Q-loop/lid; other site 762376004678 ABC transporter signature motif; other site 762376004679 Walker B; other site 762376004680 D-loop; other site 762376004681 H-loop/switch region; other site 762376004682 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376004683 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 762376004684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376004685 DNA-binding site [nucleotide binding]; DNA binding site 762376004686 FCD domain; Region: FCD; pfam07729 762376004687 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376004688 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376004689 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376004690 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 762376004691 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 762376004692 active site 762376004693 catalytic site [active] 762376004694 tetramer interface [polypeptide binding]; other site 762376004695 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 762376004696 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376004697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376004698 DNA-binding site [nucleotide binding]; DNA binding site 762376004699 FCD domain; Region: FCD; pfam07729 762376004700 Transposase, Mutator family; Region: Transposase_mut; pfam00872 762376004701 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 762376004702 MULE transposase domain; Region: MULE; pfam10551 762376004703 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376004704 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376004705 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 762376004706 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 762376004707 Catalytic domain of bacterial PuuE allantoinases, Helicobacter pylori peptidoglycan deacetylase (HpPgdA), and similar proteins; Region: CE4_PuuE_HpPgdA_like; cd10916 762376004708 active site 762376004709 catalytic site [active] 762376004710 tetramer interface [polypeptide binding]; other site 762376004711 Catalytic domain of bacterial PuuE allantoinases, Helicobacter pylori peptidoglycan deacetylase (HpPgdA), and similar proteins; Region: CE4_PuuE_HpPgdA_like; cd10916 762376004712 active site 762376004713 catalytic site [active] 762376004714 tetramer interface [polypeptide binding]; other site 762376004715 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 762376004716 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376004717 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376004718 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376004719 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376004720 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 762376004721 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 762376004722 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376004723 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376004724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376004725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376004726 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 762376004727 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 762376004728 dimer interface [polypeptide binding]; other site 762376004729 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376004730 metal binding site [ion binding]; metal-binding site 762376004731 BCCT family transporter; Region: BCCT; cl00569 762376004732 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376004733 multidrug efflux protein; Reviewed; Region: PRK09579 762376004734 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 762376004735 Predicted transcriptional regulator [Transcription]; Region: COG2345 762376004736 MarR family; Region: MarR_2; pfam12802 762376004737 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376004738 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 762376004739 multidrug efflux protein; Reviewed; Region: PRK09577 762376004740 Protein export membrane protein; Region: SecD_SecF; cl14618 762376004741 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 762376004742 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376004743 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376004744 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 762376004745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376004746 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 762376004747 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376004748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376004749 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376004750 dimerization interface [polypeptide binding]; other site 762376004751 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376004752 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 762376004753 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 762376004754 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376004755 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 762376004756 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 762376004757 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762376004758 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376004759 active site 762376004760 metal binding site [ion binding]; metal-binding site 762376004761 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 762376004762 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 762376004763 active site 762376004764 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376004765 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 762376004766 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376004767 CoenzymeA binding site [chemical binding]; other site 762376004768 subunit interaction site [polypeptide binding]; other site 762376004769 PHB binding site; other site 762376004770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376004771 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 762376004772 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 762376004773 trimer interface [polypeptide binding]; other site 762376004774 eyelet of channel; other site 762376004775 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 762376004776 NADH dehydrogenase subunit B; Validated; Region: PRK06411 762376004777 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 762376004778 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 762376004779 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 762376004780 NADH dehydrogenase subunit D; Validated; Region: PRK06075 762376004781 NADH dehydrogenase subunit E; Validated; Region: PRK07539 762376004782 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 762376004783 putative dimer interface [polypeptide binding]; other site 762376004784 [2Fe-2S] cluster binding site [ion binding]; other site 762376004785 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 762376004786 SLBB domain; Region: SLBB; pfam10531 762376004787 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 762376004788 NADH dehydrogenase subunit G; Validated; Region: PRK09129 762376004789 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376004790 catalytic loop [active] 762376004791 iron binding site [ion binding]; other site 762376004792 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 762376004793 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 762376004794 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 762376004795 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 762376004796 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 762376004797 4Fe-4S binding domain; Region: Fer4; cl02805 762376004798 4Fe-4S binding domain; Region: Fer4; cl02805 762376004799 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 762376004800 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 762376004801 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 762376004802 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 762376004803 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 762376004804 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 762376004805 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 762376004806 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 762376004807 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 762376004808 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 762376004809 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 762376004810 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376004811 N-terminal plug; other site 762376004812 ligand-binding site [chemical binding]; other site 762376004813 phosphoserine phosphatase SerB; Region: serB; TIGR00338 762376004814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376004815 motif II; other site 762376004816 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 762376004817 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 762376004818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376004819 ATP binding site [chemical binding]; other site 762376004820 putative Mg++ binding site [ion binding]; other site 762376004821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376004822 nucleotide binding region [chemical binding]; other site 762376004823 ATP-binding site [chemical binding]; other site 762376004824 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 762376004825 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 762376004826 substrate binding site; other site 762376004827 dimer interface; other site 762376004828 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 762376004829 homotrimer interaction site [polypeptide binding]; other site 762376004830 zinc binding site [ion binding]; other site 762376004831 CDP-binding sites; other site 762376004832 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 762376004833 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 762376004834 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376004835 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 762376004836 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762376004837 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 762376004838 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 762376004839 dimer interface [polypeptide binding]; other site 762376004840 decamer (pentamer of dimers) interface [polypeptide binding]; other site 762376004841 catalytic triad [active] 762376004842 peroxidatic and resolving cysteines [active] 762376004843 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376004844 dimerization interface [polypeptide binding]; other site 762376004845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376004846 dimer interface [polypeptide binding]; other site 762376004847 phosphorylation site [posttranslational modification] 762376004848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376004849 ATP binding site [chemical binding]; other site 762376004850 Mg2+ binding site [ion binding]; other site 762376004851 G-X-G motif; other site 762376004852 osmolarity response regulator; Provisional; Region: ompR; PRK09468 762376004853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376004854 active site 762376004855 phosphorylation site [posttranslational modification] 762376004856 intermolecular recognition site; other site 762376004857 dimerization interface [polypeptide binding]; other site 762376004858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376004859 DNA binding site [nucleotide binding] 762376004860 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 762376004861 Glycoprotease family; Region: Peptidase_M22; pfam00814 762376004862 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 762376004863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376004864 Coenzyme A binding pocket [chemical binding]; other site 762376004865 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 762376004866 Fe-S cluster binding site [ion binding]; other site 762376004867 active site 762376004868 lysophospholipid transporter LplT; Provisional; Region: PRK11195 762376004869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376004870 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762376004871 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 762376004872 Walker A/P-loop; other site 762376004873 ATP binding site [chemical binding]; other site 762376004874 Q-loop/lid; other site 762376004875 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 762376004876 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 762376004877 ABC transporter signature motif; other site 762376004878 Walker B; other site 762376004879 D-loop; other site 762376004880 H-loop/switch region; other site 762376004881 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 762376004882 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 762376004883 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 762376004884 nucleotide binding pocket [chemical binding]; other site 762376004885 K-X-D-G motif; other site 762376004886 catalytic site [active] 762376004887 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 762376004888 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 762376004889 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 762376004890 Dimer interface [polypeptide binding]; other site 762376004891 BRCT sequence motif; other site 762376004892 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 762376004893 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376004894 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376004895 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376004896 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762376004897 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762376004898 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 762376004899 active site 762376004900 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 762376004901 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 762376004902 active site 762376004903 iron coordination sites [ion binding]; other site 762376004904 substrate binding pocket [chemical binding]; other site 762376004905 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 762376004906 SurA N-terminal domain; Region: SurA_N_3; cl07813 762376004907 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 762376004908 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 762376004909 intracellular septation protein A; Reviewed; Region: PRK00259 762376004910 methionine sulfoxide reductase B; Provisional; Region: PRK00222 762376004911 SelR domain; Region: SelR; pfam01641 762376004912 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762376004913 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762376004914 Walker A/P-loop; other site 762376004915 ATP binding site [chemical binding]; other site 762376004916 Q-loop/lid; other site 762376004917 ABC transporter signature motif; other site 762376004918 Walker B; other site 762376004919 D-loop; other site 762376004920 H-loop/switch region; other site 762376004921 Cobalt transport protein; Region: CbiQ; cl00463 762376004922 BioY family; Region: BioY; pfam02632 762376004923 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376004924 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376004925 putative ligand binding site [chemical binding]; other site 762376004926 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 762376004927 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376004928 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376004929 TM-ABC transporter signature motif; other site 762376004930 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376004931 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376004932 TM-ABC transporter signature motif; other site 762376004933 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376004934 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376004935 Walker A/P-loop; other site 762376004936 ATP binding site [chemical binding]; other site 762376004937 Q-loop/lid; other site 762376004938 ABC transporter signature motif; other site 762376004939 Walker B; other site 762376004940 D-loop; other site 762376004941 H-loop/switch region; other site 762376004942 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376004943 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376004944 Walker A/P-loop; other site 762376004945 ATP binding site [chemical binding]; other site 762376004946 Q-loop/lid; other site 762376004947 ABC transporter signature motif; other site 762376004948 Walker B; other site 762376004949 D-loop; other site 762376004950 H-loop/switch region; other site 762376004951 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 762376004952 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 762376004953 Phosphoesterase family; Region: Phosphoesterase; pfam04185 762376004954 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376004955 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376004956 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 762376004957 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 762376004958 homodimer interface [polypeptide binding]; other site 762376004959 substrate-cofactor binding pocket; other site 762376004960 catalytic residue [active] 762376004961 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 762376004962 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 762376004963 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376004964 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376004965 TM-ABC transporter signature motif; other site 762376004966 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376004967 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376004968 TM-ABC transporter signature motif; other site 762376004969 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376004970 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376004971 putative ligand binding site [chemical binding]; other site 762376004972 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376004973 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376004974 Walker A/P-loop; other site 762376004975 ATP binding site [chemical binding]; other site 762376004976 Q-loop/lid; other site 762376004977 ABC transporter signature motif; other site 762376004978 Walker B; other site 762376004979 D-loop; other site 762376004980 H-loop/switch region; other site 762376004981 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376004982 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376004983 Walker A/P-loop; other site 762376004984 ATP binding site [chemical binding]; other site 762376004985 Q-loop/lid; other site 762376004986 ABC transporter signature motif; other site 762376004987 Walker B; other site 762376004988 D-loop; other site 762376004989 H-loop/switch region; other site 762376004990 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 762376004991 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762376004992 minor groove reading motif; other site 762376004993 helix-hairpin-helix signature motif; other site 762376004994 substrate binding pocket [chemical binding]; other site 762376004995 active site 762376004996 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 762376004997 ferredoxin; Provisional; Region: PRK08764 762376004998 Putative Fe-S cluster; Region: FeS; pfam04060 762376004999 4Fe-4S binding domain; Region: Fer4; pfam00037 762376005000 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 762376005001 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 762376005002 ferredoxin-NADP reductase; Provisional; Region: PRK10926 762376005003 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 762376005004 FAD binding pocket [chemical binding]; other site 762376005005 FAD binding motif [chemical binding]; other site 762376005006 phosphate binding motif [ion binding]; other site 762376005007 beta-alpha-beta structure motif; other site 762376005008 NAD binding pocket [chemical binding]; other site 762376005009 Ferredoxin [Energy production and conversion]; Region: COG1146 762376005010 4Fe-4S binding domain; Region: Fer4; cl02805 762376005011 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 762376005012 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 762376005013 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 762376005014 active site 762376005015 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 762376005016 homotrimer interaction site [polypeptide binding]; other site 762376005017 putative active site [active] 762376005018 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 762376005019 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 762376005020 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 762376005021 HD domain; Region: HD_4; pfam13328 762376005022 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 762376005023 synthetase active site [active] 762376005024 NTP binding site [chemical binding]; other site 762376005025 metal binding site [ion binding]; metal-binding site 762376005026 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 762376005027 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 762376005028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376005029 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376005030 putative substrate translocation pore; other site 762376005031 acetylornithine deacetylase; Provisional; Region: PRK07522 762376005032 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 762376005033 metal binding site [ion binding]; metal-binding site 762376005034 putative dimer interface [polypeptide binding]; other site 762376005035 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 762376005036 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 762376005037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005038 catalytic residue [active] 762376005039 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 762376005040 substrate binding site [chemical binding]; other site 762376005041 active site 762376005042 catalytic residues [active] 762376005043 heterodimer interface [polypeptide binding]; other site 762376005044 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 762376005045 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 762376005046 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 762376005047 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376005048 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 762376005049 galactarate dehydratase; Region: galactar-dH20; TIGR03248 762376005050 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 762376005051 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376005052 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762376005053 inhibitor site; inhibition site 762376005054 active site 762376005055 dimer interface [polypeptide binding]; other site 762376005056 catalytic residue [active] 762376005057 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376005058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376005059 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 762376005060 putative dimerization interface [polypeptide binding]; other site 762376005061 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 762376005062 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 762376005063 homodimer interface [polypeptide binding]; other site 762376005064 oligonucleotide binding site [chemical binding]; other site 762376005065 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 762376005066 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376005067 RNA binding surface [nucleotide binding]; other site 762376005068 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 762376005069 active site 762376005070 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 762376005071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376005072 motif II; other site 762376005073 TMAO/DMSO reductase; Reviewed; Region: PRK05363 762376005074 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 762376005075 Moco binding site; other site 762376005076 metal coordination site [ion binding]; other site 762376005077 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 762376005078 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 762376005079 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 762376005080 amidase catalytic site [active] 762376005081 Zn binding residues [ion binding]; other site 762376005082 substrate binding site [chemical binding]; other site 762376005083 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 762376005084 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 762376005085 putative SAM binding site [chemical binding]; other site 762376005086 homodimer interface [polypeptide binding]; other site 762376005087 Maf-like protein; Region: Maf; pfam02545 762376005088 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 762376005089 active site 762376005090 dimer interface [polypeptide binding]; other site 762376005091 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 762376005092 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 762376005093 putative phosphate acyltransferase; Provisional; Region: PRK05331 762376005094 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 762376005095 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762376005096 dimer interface [polypeptide binding]; other site 762376005097 active site 762376005098 CoA binding pocket [chemical binding]; other site 762376005099 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 762376005100 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 762376005101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376005102 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762376005103 NAD(P) binding site [chemical binding]; other site 762376005104 active site 762376005105 acyl carrier protein; Provisional; Region: acpP; PRK00982 762376005106 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 762376005107 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 762376005108 dimer interface [polypeptide binding]; other site 762376005109 active site 762376005110 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 762376005111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376005112 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376005113 DNA binding residues [nucleotide binding] 762376005114 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 762376005115 anti-sigma E factor; Provisional; Region: rseB; PRK09455 762376005116 MucB/RseB family; Region: MucB_RseB; pfam03888 762376005117 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 762376005118 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762376005119 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762376005120 protein binding site [polypeptide binding]; other site 762376005121 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762376005122 GTP-binding protein LepA; Provisional; Region: PRK05433 762376005123 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 762376005124 G1 box; other site 762376005125 putative GEF interaction site [polypeptide binding]; other site 762376005126 GTP/Mg2+ binding site [chemical binding]; other site 762376005127 Switch I region; other site 762376005128 G2 box; other site 762376005129 G3 box; other site 762376005130 Switch II region; other site 762376005131 G4 box; other site 762376005132 G5 box; other site 762376005133 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 762376005134 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 762376005135 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 762376005136 signal peptidase I; Provisional; Region: PRK10861 762376005137 HemY protein N-terminus; Region: HemY_N; pfam07219 762376005138 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762376005139 Catalytic site [active] 762376005140 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762376005141 ribonuclease III; Reviewed; Region: rnc; PRK00102 762376005142 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 762376005143 dimerization interface [polypeptide binding]; other site 762376005144 active site 762376005145 metal binding site [ion binding]; metal-binding site 762376005146 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 762376005147 dsRNA binding site [nucleotide binding]; other site 762376005148 GTPase Era; Reviewed; Region: era; PRK00089 762376005149 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 762376005150 G1 box; other site 762376005151 GTP/Mg2+ binding site [chemical binding]; other site 762376005152 Switch I region; other site 762376005153 G2 box; other site 762376005154 Switch II region; other site 762376005155 G3 box; other site 762376005156 G4 box; other site 762376005157 G5 box; other site 762376005158 KH domain; Region: KH_2; pfam07650 762376005159 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 762376005160 Recombination protein O N terminal; Region: RecO_N; pfam11967 762376005161 Recombination protein O C terminal; Region: RecO_C; pfam02565 762376005162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376005163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376005164 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376005165 putative dimerization interface [polypeptide binding]; other site 762376005166 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 762376005167 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 762376005168 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376005169 catalytic residue [active] 762376005170 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 762376005171 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 762376005172 active site 762376005173 Zn binding site [ion binding]; other site 762376005174 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376005175 TLC ATP/ADP transporter; Region: TLC; cl03940 762376005176 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762376005177 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762376005178 active site 762376005179 catalytic tetrad [active] 762376005180 YccA-like proteins; Region: YccA_like; cd10433 762376005181 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 762376005182 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 762376005183 multifunctional aminopeptidase A; Provisional; Region: PRK00913 762376005184 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 762376005185 interface (dimer of trimers) [polypeptide binding]; other site 762376005186 Substrate-binding/catalytic site; other site 762376005187 Zn-binding sites [ion binding]; other site 762376005188 Predicted permeases [General function prediction only]; Region: COG0795 762376005189 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 762376005190 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376005191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376005192 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376005193 dimerization interface [polypeptide binding]; other site 762376005194 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376005195 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376005196 putative ligand binding site [chemical binding]; other site 762376005197 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 762376005198 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 762376005199 tetrameric interface [polypeptide binding]; other site 762376005200 NAD binding site [chemical binding]; other site 762376005201 catalytic residues [active] 762376005202 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 762376005203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376005204 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 762376005205 substrate binding site [chemical binding]; other site 762376005206 dimerization interface [polypeptide binding]; other site 762376005207 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 762376005208 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 762376005209 NlpC/P60 family; Region: NLPC_P60; pfam00877 762376005210 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 762376005211 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376005212 acyl-activating enzyme (AAE) consensus motif; other site 762376005213 AMP binding site [chemical binding]; other site 762376005214 active site 762376005215 CoA binding site [chemical binding]; other site 762376005216 Domain of unknown function (DUF336); Region: DUF336; cl01249 762376005217 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 762376005218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376005219 putative substrate translocation pore; other site 762376005220 acetyl-CoA synthetase; Provisional; Region: PRK00174 762376005221 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 762376005222 active site 762376005223 CoA binding site [chemical binding]; other site 762376005224 acyl-activating enzyme (AAE) consensus motif; other site 762376005225 AMP binding site [chemical binding]; other site 762376005226 acetate binding site [chemical binding]; other site 762376005227 EamA-like transporter family; Region: EamA; pfam00892 762376005228 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376005229 EamA-like transporter family; Region: EamA; pfam00892 762376005230 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 762376005231 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 762376005232 tetramer interface [polypeptide binding]; other site 762376005233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005234 catalytic residue [active] 762376005235 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 762376005236 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376005237 inhibitor-cofactor binding pocket; inhibition site 762376005238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005239 catalytic residue [active] 762376005240 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376005241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376005242 DNA-binding site [nucleotide binding]; DNA binding site 762376005243 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376005244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 762376005245 DNA-binding site [nucleotide binding]; DNA binding site 762376005246 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376005247 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 762376005248 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 762376005249 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376005250 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376005251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376005252 dimer interface [polypeptide binding]; other site 762376005253 conserved gate region; other site 762376005254 putative PBP binding loops; other site 762376005255 ABC-ATPase subunit interface; other site 762376005256 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376005257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376005258 dimer interface [polypeptide binding]; other site 762376005259 conserved gate region; other site 762376005260 putative PBP binding loops; other site 762376005261 ABC-ATPase subunit interface; other site 762376005262 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376005263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376005264 Walker A/P-loop; other site 762376005265 ATP binding site [chemical binding]; other site 762376005266 Q-loop/lid; other site 762376005267 ABC transporter signature motif; other site 762376005268 Walker B; other site 762376005269 D-loop; other site 762376005270 H-loop/switch region; other site 762376005271 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376005272 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376005273 Walker A/P-loop; other site 762376005274 ATP binding site [chemical binding]; other site 762376005275 Q-loop/lid; other site 762376005276 ABC transporter signature motif; other site 762376005277 Walker B; other site 762376005278 D-loop; other site 762376005279 H-loop/switch region; other site 762376005280 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376005281 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 762376005282 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 762376005283 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 762376005284 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762376005285 putative NAD(P) binding site [chemical binding]; other site 762376005286 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 762376005287 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 762376005288 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 762376005289 active site 762376005290 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 762376005291 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 762376005292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376005293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762376005294 Coenzyme A binding pocket [chemical binding]; other site 762376005295 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376005296 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 762376005297 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 762376005298 putative active site [active] 762376005299 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cd04512 762376005300 active site 762376005301 dimer interface [polypeptide binding]; other site 762376005302 catalytic nucleophile [active] 762376005303 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 762376005304 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376005305 Walker A/P-loop; other site 762376005306 ATP binding site [chemical binding]; other site 762376005307 Q-loop/lid; other site 762376005308 ABC transporter signature motif; other site 762376005309 Walker B; other site 762376005310 D-loop; other site 762376005311 H-loop/switch region; other site 762376005312 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376005313 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376005314 Walker A/P-loop; other site 762376005315 ATP binding site [chemical binding]; other site 762376005316 Q-loop/lid; other site 762376005317 ABC transporter signature motif; other site 762376005318 Walker B; other site 762376005319 D-loop; other site 762376005320 H-loop/switch region; other site 762376005321 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376005322 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 762376005323 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 762376005324 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 762376005325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376005326 dimer interface [polypeptide binding]; other site 762376005327 conserved gate region; other site 762376005328 putative PBP binding loops; other site 762376005329 ABC-ATPase subunit interface; other site 762376005330 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 762376005331 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 762376005332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376005333 dimer interface [polypeptide binding]; other site 762376005334 conserved gate region; other site 762376005335 putative PBP binding loops; other site 762376005336 ABC-ATPase subunit interface; other site 762376005337 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 762376005338 homodimer interface [polypeptide binding]; other site 762376005339 homotetramer interface [polypeptide binding]; other site 762376005340 active site pocket [active] 762376005341 cleavage site 762376005342 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 762376005343 SxDxEG motif; other site 762376005344 active site 762376005345 metal binding site [ion binding]; metal-binding site 762376005346 homopentamer interface [polypeptide binding]; other site 762376005347 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762376005348 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762376005349 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762376005350 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 762376005351 active site 762376005352 CTP synthetase; Validated; Region: pyrG; PRK05380 762376005353 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 762376005354 Catalytic site [active] 762376005355 active site 762376005356 UTP binding site [chemical binding]; other site 762376005357 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 762376005358 active site 762376005359 putative oxyanion hole; other site 762376005360 catalytic triad [active] 762376005361 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 762376005362 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 762376005363 enolase; Provisional; Region: eno; PRK00077 762376005364 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 762376005365 dimer interface [polypeptide binding]; other site 762376005366 metal binding site [ion binding]; metal-binding site 762376005367 substrate binding pocket [chemical binding]; other site 762376005368 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 762376005369 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 762376005370 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 762376005371 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 762376005372 dimerization interface [polypeptide binding]; other site 762376005373 domain crossover interface; other site 762376005374 redox-dependent activation switch; other site 762376005375 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 762376005376 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 762376005377 trimer interface [polypeptide binding]; other site 762376005378 putative metal binding site [ion binding]; other site 762376005379 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 762376005380 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 762376005381 active site 762376005382 acyl-activating enzyme (AAE) consensus motif; other site 762376005383 putative CoA binding site [chemical binding]; other site 762376005384 AMP binding site [chemical binding]; other site 762376005385 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376005386 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 762376005387 putative active site [active] 762376005388 putative metal binding site [ion binding]; other site 762376005389 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 762376005390 RDD family; Region: RDD; pfam06271 762376005391 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 762376005392 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 762376005393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376005394 Predicted membrane protein [Function unknown]; Region: COG1981 762376005395 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 762376005396 2-methylcitrate dehydratase; Region: prpD; TIGR02330 762376005397 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 762376005398 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 762376005399 dimer interface [polypeptide binding]; other site 762376005400 active site 762376005401 citrylCoA binding site [chemical binding]; other site 762376005402 oxalacetate/citrate binding site [chemical binding]; other site 762376005403 coenzyme A binding site [chemical binding]; other site 762376005404 catalytic triad [active] 762376005405 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 762376005406 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762376005407 tetramer interface [polypeptide binding]; other site 762376005408 active site 762376005409 Mg2+/Mn2+ binding site [ion binding]; other site 762376005410 malate dehydrogenase; Provisional; Region: PRK05442 762376005411 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 762376005412 NAD(P) binding site [chemical binding]; other site 762376005413 dimer interface [polypeptide binding]; other site 762376005414 malate binding site [chemical binding]; other site 762376005415 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376005416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376005417 DNA-binding site [nucleotide binding]; DNA binding site 762376005418 UTRA domain; Region: UTRA; pfam07702 762376005419 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 762376005420 Iron-sulfur protein interface; other site 762376005421 proximal quinone binding site [chemical binding]; other site 762376005422 SdhD (CybS) interface [polypeptide binding]; other site 762376005423 proximal heme binding site [chemical binding]; other site 762376005424 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 762376005425 SdhC subunit interface [polypeptide binding]; other site 762376005426 proximal heme binding site [chemical binding]; other site 762376005427 cardiolipin binding site; other site 762376005428 Iron-sulfur protein interface; other site 762376005429 proximal quinone binding site [chemical binding]; other site 762376005430 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 762376005431 L-aspartate oxidase; Provisional; Region: PRK06175 762376005432 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 762376005433 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 762376005434 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 762376005435 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 762376005436 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 762376005437 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 762376005438 dimer interface [polypeptide binding]; other site 762376005439 active site 762376005440 citrylCoA binding site [chemical binding]; other site 762376005441 NADH binding [chemical binding]; other site 762376005442 cationic pore residues; other site 762376005443 oxalacetate/citrate binding site [chemical binding]; other site 762376005444 coenzyme A binding site [chemical binding]; other site 762376005445 catalytic triad [active] 762376005446 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 762376005447 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 762376005448 Malic enzyme, N-terminal domain; Region: malic; pfam00390 762376005449 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 762376005450 putative NAD(P) binding site [chemical binding]; other site 762376005451 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 762376005452 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 762376005453 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 762376005454 dimer interface [polypeptide binding]; other site 762376005455 TPP-binding site [chemical binding]; other site 762376005456 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 762376005457 Predicted membrane protein [Function unknown]; Region: COG1297 762376005458 putative oligopeptide transporter, OPT family; Region: TIGR00733 762376005459 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 762376005460 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 762376005461 putative metal binding site [ion binding]; other site 762376005462 putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590 762376005463 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 762376005464 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762376005465 active site 762376005466 metal binding site [ion binding]; metal-binding site 762376005467 dimer interface [polypeptide binding]; other site 762376005468 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 762376005469 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 762376005470 active site 762376005471 catalytic site [active] 762376005472 tetramer interface [polypeptide binding]; other site 762376005473 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 762376005474 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 762376005475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005476 catalytic residue [active] 762376005477 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 762376005478 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 762376005479 putative DNA binding site [nucleotide binding]; other site 762376005480 putative Zn2+ binding site [ion binding]; other site 762376005481 AsnC family; Region: AsnC_trans_reg; pfam01037 762376005482 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 762376005483 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 762376005484 TPP-binding site [chemical binding]; other site 762376005485 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 762376005486 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 762376005487 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376005488 E3 interaction surface; other site 762376005489 lipoyl attachment site [posttranslational modification]; other site 762376005490 e3 binding domain; Region: E3_binding; pfam02817 762376005491 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762376005492 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 762376005493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376005494 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376005495 Predicted ATPase [General function prediction only]; Region: COG1485 762376005496 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376005497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376005498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376005499 DNA binding residues [nucleotide binding] 762376005500 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376005501 FecR protein; Region: FecR; pfam04773 762376005502 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376005503 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376005504 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376005505 N-terminal plug; other site 762376005506 ligand-binding site [chemical binding]; other site 762376005507 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 762376005508 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376005509 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 762376005510 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 762376005511 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 762376005512 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 762376005513 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 762376005514 active site 762376005515 HIGH motif; other site 762376005516 dimer interface [polypeptide binding]; other site 762376005517 KMSKS motif; other site 762376005518 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 762376005519 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 762376005520 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 762376005521 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 762376005522 RNA binding site [nucleotide binding]; other site 762376005523 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 762376005524 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 762376005525 ATP binding site [chemical binding]; other site 762376005526 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 762376005527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376005528 putative substrate translocation pore; other site 762376005529 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376005530 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 762376005531 conserved cys residue [active] 762376005532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376005533 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 762376005534 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762376005535 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376005536 RNA binding surface [nucleotide binding]; other site 762376005537 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 762376005538 active site 762376005539 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 762376005540 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 762376005541 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 762376005542 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 762376005543 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 762376005544 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 762376005545 NAD(P) binding site [chemical binding]; other site 762376005546 homotetramer interface [polypeptide binding]; other site 762376005547 homodimer interface [polypeptide binding]; other site 762376005548 active site 762376005549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 762376005550 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 762376005551 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 762376005552 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 762376005553 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 762376005554 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 762376005555 Fe2+ transport protein; Region: Iron_transport; pfam10634 762376005556 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 762376005557 Iron permease FTR1 family; Region: FTR1; cl00475 762376005558 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 762376005559 4Fe-4S binding domain; Region: Fer4_5; pfam12801 762376005560 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 762376005561 BON domain; Region: BON; pfam04972 762376005562 CsbD-like; Region: CsbD; cl17424 762376005563 cyanophycin synthetase; Provisional; Region: PRK14016 762376005564 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762376005565 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376005566 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376005567 cyanophycin synthetase; Provisional; Region: PRK14016 762376005568 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 762376005569 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376005570 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376005571 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762376005572 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762376005573 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 762376005574 Walker A/P-loop; other site 762376005575 ATP binding site [chemical binding]; other site 762376005576 Q-loop/lid; other site 762376005577 ABC transporter signature motif; other site 762376005578 Walker B; other site 762376005579 D-loop; other site 762376005580 H-loop/switch region; other site 762376005581 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 762376005582 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 762376005583 Protein of unknown function, DUF482; Region: DUF482; pfam04339 762376005584 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 762376005585 dinuclear metal binding motif [ion binding]; other site 762376005586 Transglycosylase SLT domain; Region: SLT_2; pfam13406 762376005587 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762376005588 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376005589 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 762376005590 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 762376005591 hypothetical protein; Provisional; Region: PRK09936 762376005592 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 762376005593 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 762376005594 active site 762376005595 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 762376005596 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 762376005597 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 762376005598 active site 762376005599 homodimer interface [polypeptide binding]; other site 762376005600 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376005601 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376005602 substrate binding site [chemical binding]; other site 762376005603 oxyanion hole (OAH) forming residues; other site 762376005604 trimer interface [polypeptide binding]; other site 762376005605 putative CoA-transferase; Provisional; Region: PRK11430 762376005606 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376005607 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376005608 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376005609 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376005610 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376005611 active site 762376005612 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376005613 CoA binding domain; Region: CoA_binding_2; pfam13380 762376005614 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762376005615 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762376005616 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376005617 active site 2 [active] 762376005618 active site 1 [active] 762376005619 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376005620 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 762376005621 NAD(P) binding site [chemical binding]; other site 762376005622 homotetramer interface [polypeptide binding]; other site 762376005623 homodimer interface [polypeptide binding]; other site 762376005624 active site 762376005625 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376005626 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376005627 enoyl-CoA hydratase; Region: PLN02864 762376005628 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376005629 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 762376005630 dimer interaction site [polypeptide binding]; other site 762376005631 substrate-binding tunnel; other site 762376005632 active site 762376005633 catalytic site [active] 762376005634 substrate binding site [chemical binding]; other site 762376005635 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 762376005636 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 762376005637 acyl-activating enzyme (AAE) consensus motif; other site 762376005638 putative AMP binding site [chemical binding]; other site 762376005639 putative active site [active] 762376005640 putative CoA binding site [chemical binding]; other site 762376005641 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376005642 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376005643 active site 762376005644 thiolase; Provisional; Region: PRK06158 762376005645 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376005646 active site 762376005647 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 762376005648 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376005649 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376005650 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376005651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376005652 putative substrate translocation pore; other site 762376005653 phosphoglycolate phosphatase; Provisional; Region: PRK13222 762376005654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376005655 motif II; other site 762376005656 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 762376005657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376005658 S-adenosylmethionine binding site [chemical binding]; other site 762376005659 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 762376005660 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376005661 ligand binding site [chemical binding]; other site 762376005662 DNA gyrase subunit A; Validated; Region: PRK05560 762376005663 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 762376005664 CAP-like domain; other site 762376005665 active site 762376005666 primary dimer interface [polypeptide binding]; other site 762376005667 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762376005668 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762376005669 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762376005670 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762376005671 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762376005672 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762376005673 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 762376005674 homodimer interface [polypeptide binding]; other site 762376005675 substrate-cofactor binding pocket; other site 762376005676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005677 catalytic residue [active] 762376005678 Chorismate mutase type II; Region: CM_2; cl00693 762376005679 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 762376005680 Prephenate dehydratase; Region: PDT; pfam00800 762376005681 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 762376005682 putative L-Phe binding site [chemical binding]; other site 762376005683 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 762376005684 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376005685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005686 homodimer interface [polypeptide binding]; other site 762376005687 catalytic residue [active] 762376005688 prephenate dehydrogenase; Validated; Region: PRK08507 762376005689 Prephenate dehydrogenase; Region: PDH; pfam02153 762376005690 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 762376005691 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 762376005692 hinge; other site 762376005693 active site 762376005694 cytidylate kinase; Provisional; Region: cmk; PRK00023 762376005695 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 762376005696 CMP-binding site; other site 762376005697 The sites determining sugar specificity; other site 762376005698 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 762376005699 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 762376005700 RNA binding site [nucleotide binding]; other site 762376005701 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 762376005702 RNA binding site [nucleotide binding]; other site 762376005703 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 762376005704 RNA binding site [nucleotide binding]; other site 762376005705 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 762376005706 RNA binding site [nucleotide binding]; other site 762376005707 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 762376005708 RNA binding site [nucleotide binding]; other site 762376005709 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 762376005710 RNA binding site [nucleotide binding]; other site 762376005711 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 762376005712 IHF dimer interface [polypeptide binding]; other site 762376005713 IHF - DNA interface [nucleotide binding]; other site 762376005714 tetratricopeptide repeat protein; Provisional; Region: PRK11788 762376005715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762376005716 binding surface 762376005717 TPR motif; other site 762376005718 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762376005719 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 762376005720 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 762376005721 putative ribose interaction site [chemical binding]; other site 762376005722 putative ADP binding site [chemical binding]; other site 762376005723 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 762376005724 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 762376005725 NADP binding site [chemical binding]; other site 762376005726 homopentamer interface [polypeptide binding]; other site 762376005727 substrate binding site [chemical binding]; other site 762376005728 active site 762376005729 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 762376005730 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 762376005731 cysteine synthase B; Region: cysM; TIGR01138 762376005732 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 762376005733 dimer interface [polypeptide binding]; other site 762376005734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005735 catalytic residue [active] 762376005736 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376005737 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376005738 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376005739 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376005740 Putative cyclase; Region: Cyclase; cl00814 762376005741 Putative cyclase; Region: Cyclase; cl00814 762376005742 Transglycosylase SLT domain; Region: SLT_2; pfam13406 762376005743 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762376005744 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376005745 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 762376005746 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 762376005747 putative active site [active] 762376005748 Zn binding site [ion binding]; other site 762376005749 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 762376005750 Ligand binding site [chemical binding]; other site 762376005751 Electron transfer flavoprotein domain; Region: ETF; pfam01012 762376005752 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 762376005753 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 762376005754 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 762376005755 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 762376005756 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 762376005757 TrkA-C domain; Region: TrkA_C; pfam02080 762376005758 TrkA-C domain; Region: TrkA_C; pfam02080 762376005759 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 762376005760 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 762376005761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376005762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376005763 homodimer interface [polypeptide binding]; other site 762376005764 catalytic residue [active] 762376005765 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 762376005766 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 762376005767 TrkA-C domain; Region: TrkA_C; pfam02080 762376005768 TrkA-C domain; Region: TrkA_C; pfam02080 762376005769 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 762376005770 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 762376005771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376005772 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376005773 putative dimerization interface [polypeptide binding]; other site 762376005774 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376005775 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376005776 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376005777 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376005778 substrate binding site [chemical binding]; other site 762376005779 oxyanion hole (OAH) forming residues; other site 762376005780 trimer interface [polypeptide binding]; other site 762376005781 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376005782 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 762376005783 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 762376005784 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376005785 active site 762376005786 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 762376005787 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 762376005788 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 762376005789 dimer interface [polypeptide binding]; other site 762376005790 decamer (pentamer of dimers) interface [polypeptide binding]; other site 762376005791 catalytic triad [active] 762376005792 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 762376005793 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 762376005794 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 762376005795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376005796 dimer interface [polypeptide binding]; other site 762376005797 conserved gate region; other site 762376005798 putative PBP binding loops; other site 762376005799 ABC-ATPase subunit interface; other site 762376005800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376005801 dimer interface [polypeptide binding]; other site 762376005802 conserved gate region; other site 762376005803 putative PBP binding loops; other site 762376005804 ABC-ATPase subunit interface; other site 762376005805 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 762376005806 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 762376005807 Walker A/P-loop; other site 762376005808 ATP binding site [chemical binding]; other site 762376005809 Q-loop/lid; other site 762376005810 ABC transporter signature motif; other site 762376005811 Walker B; other site 762376005812 D-loop; other site 762376005813 H-loop/switch region; other site 762376005814 TOBE-like domain; Region: TOBE_3; pfam12857 762376005815 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 762376005816 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 762376005817 Active Sites [active] 762376005818 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 762376005819 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 762376005820 Active Sites [active] 762376005821 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 762376005822 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 762376005823 CysD dimerization site [polypeptide binding]; other site 762376005824 G1 box; other site 762376005825 putative GEF interaction site [polypeptide binding]; other site 762376005826 GTP/Mg2+ binding site [chemical binding]; other site 762376005827 Switch I region; other site 762376005828 G2 box; other site 762376005829 G3 box; other site 762376005830 Switch II region; other site 762376005831 G4 box; other site 762376005832 G5 box; other site 762376005833 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 762376005834 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 762376005835 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 762376005836 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762376005837 FeS/SAM binding site; other site 762376005838 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 762376005839 EamA-like transporter family; Region: EamA; cl17759 762376005840 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 762376005841 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 762376005842 putative active site [active] 762376005843 putative CoA binding site [chemical binding]; other site 762376005844 nudix motif; other site 762376005845 metal binding site [ion binding]; metal-binding site 762376005846 GTPase RsgA; Reviewed; Region: PRK00098 762376005847 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 762376005848 RNA binding site [nucleotide binding]; other site 762376005849 homodimer interface [polypeptide binding]; other site 762376005850 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 762376005851 GTPase/Zn-binding domain interface [polypeptide binding]; other site 762376005852 GTP/Mg2+ binding site [chemical binding]; other site 762376005853 G4 box; other site 762376005854 G5 box; other site 762376005855 G1 box; other site 762376005856 Switch I region; other site 762376005857 G2 box; other site 762376005858 G3 box; other site 762376005859 Switch II region; other site 762376005860 Peptidase family M48; Region: Peptidase_M48; pfam01435 762376005861 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 762376005862 catalytic site [active] 762376005863 putative active site [active] 762376005864 putative substrate binding site [chemical binding]; other site 762376005865 dimer interface [polypeptide binding]; other site 762376005866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376005867 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 762376005868 Walker A motif; other site 762376005869 ATP binding site [chemical binding]; other site 762376005870 Walker B motif; other site 762376005871 arginine finger; other site 762376005872 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762376005873 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376005874 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 762376005875 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 762376005876 Uncharacterized conserved protein [Function unknown]; Region: COG0062 762376005877 PaaX-like protein; Region: PaaX; pfam07848 762376005878 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 762376005879 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 762376005880 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 762376005881 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 762376005882 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 762376005883 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 762376005884 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 762376005885 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 762376005886 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 762376005887 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 762376005888 FAD binding pocket [chemical binding]; other site 762376005889 FAD binding motif [chemical binding]; other site 762376005890 phosphate binding motif [ion binding]; other site 762376005891 beta-alpha-beta structure motif; other site 762376005892 NAD(p) ribose binding residues [chemical binding]; other site 762376005893 NAD binding pocket [chemical binding]; other site 762376005894 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 762376005895 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376005896 catalytic loop [active] 762376005897 iron binding site [ion binding]; other site 762376005898 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 762376005899 Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Region: ALDH_PAD-PaaZ; cd07127 762376005900 NADP binding site [chemical binding]; other site 762376005901 catalytic residues [active] 762376005902 enoyl-CoA hydratase; Provisional; Region: PRK08140 762376005903 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376005904 substrate binding site [chemical binding]; other site 762376005905 oxyanion hole (OAH) forming residues; other site 762376005906 trimer interface [polypeptide binding]; other site 762376005907 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376005908 CoenzymeA binding site [chemical binding]; other site 762376005909 subunit interaction site [polypeptide binding]; other site 762376005910 PHB binding site; other site 762376005911 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 762376005912 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 762376005913 active site 762376005914 AMP binding site [chemical binding]; other site 762376005915 homodimer interface [polypeptide binding]; other site 762376005916 acyl-activating enzyme (AAE) consensus motif; other site 762376005917 CoA binding site [chemical binding]; other site 762376005918 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 762376005919 cation binding site [ion binding]; other site 762376005920 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 762376005921 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 762376005922 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 762376005923 arylformamidase; Region: trp_arylform; TIGR03035 762376005924 hypothetical protein; Reviewed; Region: PRK00024 762376005925 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 762376005926 MPN+ (JAMM) motif; other site 762376005927 Zinc-binding site [ion binding]; other site 762376005928 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 762376005929 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 762376005930 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 762376005931 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 762376005932 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 762376005933 maleylacetoacetate isomerase; Region: maiA; TIGR01262 762376005934 C-terminal domain interface [polypeptide binding]; other site 762376005935 GSH binding site (G-site) [chemical binding]; other site 762376005936 putative dimer interface [polypeptide binding]; other site 762376005937 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 762376005938 dimer interface [polypeptide binding]; other site 762376005939 N-terminal domain interface [polypeptide binding]; other site 762376005940 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 762376005941 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 762376005942 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762376005943 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762376005944 protein binding site [polypeptide binding]; other site 762376005945 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762376005946 protein binding site [polypeptide binding]; other site 762376005947 sensor protein QseC; Provisional; Region: PRK10337 762376005948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376005949 dimer interface [polypeptide binding]; other site 762376005950 phosphorylation site [posttranslational modification] 762376005951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376005952 ATP binding site [chemical binding]; other site 762376005953 Mg2+ binding site [ion binding]; other site 762376005954 G-X-G motif; other site 762376005955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376005956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376005957 active site 762376005958 phosphorylation site [posttranslational modification] 762376005959 intermolecular recognition site; other site 762376005960 dimerization interface [polypeptide binding]; other site 762376005961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376005962 DNA binding site [nucleotide binding] 762376005963 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 762376005964 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762376005965 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 762376005966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376005967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376005968 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376005969 putative effector binding pocket; other site 762376005970 dimerization interface [polypeptide binding]; other site 762376005971 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 762376005972 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 762376005973 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376005974 RNA binding surface [nucleotide binding]; other site 762376005975 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 762376005976 probable active site [active] 762376005977 ribosome maturation protein RimP; Reviewed; Region: PRK00092 762376005978 Sm and related proteins; Region: Sm_like; cl00259 762376005979 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 762376005980 putative oligomer interface [polypeptide binding]; other site 762376005981 putative RNA binding site [nucleotide binding]; other site 762376005982 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 762376005983 NusA N-terminal domain; Region: NusA_N; pfam08529 762376005984 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 762376005985 RNA binding site [nucleotide binding]; other site 762376005986 homodimer interface [polypeptide binding]; other site 762376005987 NusA-like KH domain; Region: KH_5; pfam13184 762376005988 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 762376005989 G-X-X-G motif; other site 762376005990 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 762376005991 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 762376005992 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 762376005993 translation initiation factor IF-2; Region: IF-2; TIGR00487 762376005994 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 762376005995 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 762376005996 G1 box; other site 762376005997 putative GEF interaction site [polypeptide binding]; other site 762376005998 GTP/Mg2+ binding site [chemical binding]; other site 762376005999 Switch I region; other site 762376006000 G2 box; other site 762376006001 G3 box; other site 762376006002 Switch II region; other site 762376006003 G4 box; other site 762376006004 G5 box; other site 762376006005 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 762376006006 Translation-initiation factor 2; Region: IF-2; pfam11987 762376006007 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 762376006008 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 762376006009 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00020 762376006010 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 762376006011 RNA binding site [nucleotide binding]; other site 762376006012 active site 762376006013 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 762376006014 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 762376006015 G1 box; other site 762376006016 putative GEF interaction site [polypeptide binding]; other site 762376006017 GTP/Mg2+ binding site [chemical binding]; other site 762376006018 Switch I region; other site 762376006019 G2 box; other site 762376006020 G3 box; other site 762376006021 Switch II region; other site 762376006022 G4 box; other site 762376006023 G5 box; other site 762376006024 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 762376006025 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 762376006026 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 762376006027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376006028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376006029 dimerization interface [polypeptide binding]; other site 762376006030 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 762376006031 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 762376006032 octamer interface [polypeptide binding]; other site 762376006033 active site 762376006034 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 762376006035 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 762376006036 active site 762376006037 benzoate transport; Region: 2A0115; TIGR00895 762376006038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376006039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376006040 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 762376006041 NAD(P) binding site [chemical binding]; other site 762376006042 active site 762376006043 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376006044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376006045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376006046 dimerization interface [polypeptide binding]; other site 762376006047 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376006048 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 762376006049 amidohydrolase; Region: amidohydrolases; TIGR01891 762376006050 putative metal binding site [ion binding]; other site 762376006051 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 762376006052 DNA polymerase I; Provisional; Region: PRK05755 762376006053 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 762376006054 active site 762376006055 metal binding site 1 [ion binding]; metal-binding site 762376006056 putative 5' ssDNA interaction site; other site 762376006057 metal binding site 3; metal-binding site 762376006058 metal binding site 2 [ion binding]; metal-binding site 762376006059 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 762376006060 putative DNA binding site [nucleotide binding]; other site 762376006061 putative metal binding site [ion binding]; other site 762376006062 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 762376006063 active site 762376006064 catalytic site [active] 762376006065 substrate binding site [chemical binding]; other site 762376006066 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 762376006067 active site 762376006068 DNA binding site [nucleotide binding] 762376006069 catalytic site [active] 762376006070 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 762376006071 Dienelactone hydrolase family; Region: DLH; pfam01738 762376006072 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762376006073 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 762376006074 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 762376006075 PhoU domain; Region: PhoU; pfam01895 762376006076 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 762376006077 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 762376006078 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 762376006079 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 762376006080 heat shock protein HtpX; Provisional; Region: PRK05457 762376006081 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376006082 EamA-like transporter family; Region: EamA; cl17759 762376006083 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 762376006084 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 762376006085 active site residue [active] 762376006086 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 762376006087 active site residue [active] 762376006088 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376006089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376006090 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 762376006091 putative dimerization interface [polypeptide binding]; other site 762376006092 putative effector binding pocket; other site 762376006093 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376006094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376006095 putative substrate translocation pore; other site 762376006096 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 762376006097 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 762376006098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376006099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376006100 dimerization interface [polypeptide binding]; other site 762376006101 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 762376006102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376006103 Walker A/P-loop; other site 762376006104 ATP binding site [chemical binding]; other site 762376006105 Q-loop/lid; other site 762376006106 ABC transporter signature motif; other site 762376006107 Walker B; other site 762376006108 D-loop; other site 762376006109 H-loop/switch region; other site 762376006110 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 762376006111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376006112 dimer interface [polypeptide binding]; other site 762376006113 conserved gate region; other site 762376006114 putative PBP binding loops; other site 762376006115 ABC-ATPase subunit interface; other site 762376006116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376006117 dimer interface [polypeptide binding]; other site 762376006118 conserved gate region; other site 762376006119 putative PBP binding loops; other site 762376006120 ABC-ATPase subunit interface; other site 762376006121 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 762376006122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376006123 motif II; other site 762376006124 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 762376006125 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 762376006126 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762376006127 hydroxyglutarate oxidase; Provisional; Region: PRK11728 762376006128 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 762376006129 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 762376006130 putative hydrophobic ligand binding site [chemical binding]; other site 762376006131 protein interface [polypeptide binding]; other site 762376006132 gate; other site 762376006133 Dienelactone hydrolase family; Region: DLH; pfam01738 762376006134 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762376006135 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 762376006136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376006137 Zn binding site [ion binding]; other site 762376006138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376006139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376006140 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376006141 putative dimerization interface [polypeptide binding]; other site 762376006142 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376006143 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 762376006144 [2Fe-2S] cluster binding site [ion binding]; other site 762376006145 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 762376006146 alpha subunit interface [polypeptide binding]; other site 762376006147 active site 762376006148 substrate binding site [chemical binding]; other site 762376006149 Fe binding site [ion binding]; other site 762376006150 Acyltransferase family; Region: Acyl_transf_3; pfam01757 762376006151 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 762376006152 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376006153 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376006154 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 762376006155 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 762376006156 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 762376006157 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762376006158 substrate binding pocket [chemical binding]; other site 762376006159 chain length determination region; other site 762376006160 substrate-Mg2+ binding site; other site 762376006161 catalytic residues [active] 762376006162 aspartate-rich region 1; other site 762376006163 active site lid residues [active] 762376006164 aspartate-rich region 2; other site 762376006165 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 762376006166 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 762376006167 TPP-binding site; other site 762376006168 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762376006169 PYR/PP interface [polypeptide binding]; other site 762376006170 dimer interface [polypeptide binding]; other site 762376006171 TPP binding site [chemical binding]; other site 762376006172 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376006173 putative GTP cyclohydrolase; Provisional; Region: PRK13674 762376006174 Protein of unknown function (DUF817); Region: DUF817; pfam05675 762376006175 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 762376006176 primosomal replication protein N; Reviewed; Region: PRK00036 762376006177 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 762376006178 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 762376006179 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 762376006180 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 762376006181 serine/threonine protein kinase; Provisional; Region: PRK14879 762376006182 replicative DNA helicase; Provisional; Region: PRK07004 762376006183 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 762376006184 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 762376006185 Walker A motif; other site 762376006186 ATP binding site [chemical binding]; other site 762376006187 Walker B motif; other site 762376006188 DNA binding loops [nucleotide binding] 762376006189 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 762376006190 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 762376006191 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 762376006192 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 762376006193 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376006194 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 762376006195 AsnC family; Region: AsnC_trans_reg; pfam01037 762376006196 P-type ATPase of unknown pump specificity (type V); Region: P-ATPase-V; TIGR01657 762376006197 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 762376006198 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 762376006199 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376006200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376006201 DNA-binding site [nucleotide binding]; DNA binding site 762376006202 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376006203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376006204 homodimer interface [polypeptide binding]; other site 762376006205 catalytic residue [active] 762376006206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762376006207 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 762376006208 Predicted small secreted protein [Function unknown]; Region: COG5510 762376006209 aspartate carbamoyltransferase; Provisional; Region: PRK11891 762376006210 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762376006211 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762376006212 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 762376006213 heme-binding site [chemical binding]; other site 762376006214 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376006215 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376006216 metal binding site [ion binding]; metal-binding site 762376006217 active site 762376006218 I-site; other site 762376006219 recombination associated protein; Reviewed; Region: rdgC; PRK00321 762376006220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376006221 putative substrate translocation pore; other site 762376006222 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 762376006223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376006224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376006225 dimer interface [polypeptide binding]; other site 762376006226 phosphorylation site [posttranslational modification] 762376006227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376006228 ATP binding site [chemical binding]; other site 762376006229 G-X-G motif; other site 762376006230 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376006231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376006232 active site 762376006233 phosphorylation site [posttranslational modification] 762376006234 intermolecular recognition site; other site 762376006235 dimerization interface [polypeptide binding]; other site 762376006236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376006237 DNA binding site [nucleotide binding] 762376006238 recombinase A; Provisional; Region: recA; PRK09354 762376006239 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 762376006240 hexamer interface [polypeptide binding]; other site 762376006241 Walker A motif; other site 762376006242 ATP binding site [chemical binding]; other site 762376006243 Walker B motif; other site 762376006244 recombination regulator RecX; Reviewed; Region: recX; PRK00117 762376006245 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 762376006246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376006247 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 762376006248 putative dimerization interface [polypeptide binding]; other site 762376006249 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 762376006250 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 762376006251 THF binding site; other site 762376006252 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 762376006253 substrate binding site [chemical binding]; other site 762376006254 THF binding site; other site 762376006255 zinc-binding site [ion binding]; other site 762376006256 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 762376006257 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 762376006258 acyl-activating enzyme (AAE) consensus motif; other site 762376006259 AMP binding site [chemical binding]; other site 762376006260 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 762376006261 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762376006262 putative trimer interface [polypeptide binding]; other site 762376006263 putative CoA binding site [chemical binding]; other site 762376006264 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762376006265 putative trimer interface [polypeptide binding]; other site 762376006266 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762376006267 putative CoA binding site [chemical binding]; other site 762376006268 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762376006269 putative trimer interface [polypeptide binding]; other site 762376006270 putative CoA binding site [chemical binding]; other site 762376006271 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 762376006272 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 762376006273 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 762376006274 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 762376006275 CoA-ligase; Region: Ligase_CoA; pfam00549 762376006276 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 762376006277 CoA binding domain; Region: CoA_binding; smart00881 762376006278 CoA-ligase; Region: Ligase_CoA; pfam00549 762376006279 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 762376006280 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 762376006281 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 762376006282 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 762376006283 domain interfaces; other site 762376006284 active site 762376006285 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 762376006286 active site 762376006287 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 762376006288 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 762376006289 HemY protein N-terminus; Region: HemY_N; pfam07219 762376006290 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 762376006291 dimer interface [polypeptide binding]; other site 762376006292 substrate binding site [chemical binding]; other site 762376006293 metal binding sites [ion binding]; metal-binding site 762376006294 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376006295 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376006296 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376006297 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376006298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376006299 NAD(P) binding site [chemical binding]; other site 762376006300 active site 762376006301 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376006302 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376006303 putative ligand binding site [chemical binding]; other site 762376006304 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 762376006305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376006306 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376006307 NAD(P) binding site [chemical binding]; other site 762376006308 active site 762376006309 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376006310 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376006311 Walker A/P-loop; other site 762376006312 ATP binding site [chemical binding]; other site 762376006313 Q-loop/lid; other site 762376006314 ABC transporter signature motif; other site 762376006315 Walker B; other site 762376006316 D-loop; other site 762376006317 H-loop/switch region; other site 762376006318 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376006319 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376006320 Walker A/P-loop; other site 762376006321 ATP binding site [chemical binding]; other site 762376006322 Q-loop/lid; other site 762376006323 ABC transporter signature motif; other site 762376006324 Walker B; other site 762376006325 D-loop; other site 762376006326 H-loop/switch region; other site 762376006327 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376006328 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376006329 TM-ABC transporter signature motif; other site 762376006330 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376006331 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376006332 TM-ABC transporter signature motif; other site 762376006333 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 762376006334 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376006335 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376006336 Predicted small secreted protein [Function unknown]; Region: COG5510 762376006337 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 762376006338 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 762376006339 putative active site [active] 762376006340 PhoH-like protein; Region: PhoH; pfam02562 762376006341 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 762376006342 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 762376006343 catalytic triad [active] 762376006344 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 762376006345 aminotransferase; Validated; Region: PRK08175 762376006346 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376006347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376006348 homodimer interface [polypeptide binding]; other site 762376006349 catalytic residue [active] 762376006350 homoserine dehydrogenase; Provisional; Region: PRK06349 762376006351 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 762376006352 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 762376006353 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 762376006354 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 762376006355 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 762376006356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376006357 catalytic residue [active] 762376006358 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 762376006359 fructose-1,6-bisphosphatase family protein; Region: PLN02628 762376006360 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 762376006361 AMP binding site [chemical binding]; other site 762376006362 metal binding site [ion binding]; metal-binding site 762376006363 active site 762376006364 aminopeptidase N; Provisional; Region: pepN; PRK14015 762376006365 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 762376006366 active site 762376006367 Zn binding site [ion binding]; other site 762376006368 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 762376006369 H-NS histone family; Region: Histone_HNS; pfam00816 762376006370 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 762376006371 protease TldD; Provisional; Region: tldD; PRK10735 762376006372 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 762376006373 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 762376006374 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376006375 FAD binding domain; Region: FAD_binding_4; pfam01565 762376006376 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 762376006377 FAD binding domain; Region: FAD_binding_4; pfam01565 762376006378 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 762376006379 FAD binding domain; Region: FAD_binding_4; pfam01565 762376006380 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 762376006381 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 762376006382 Cysteine-rich domain; Region: CCG; pfam02754 762376006383 Cysteine-rich domain; Region: CCG; pfam02754 762376006384 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 762376006385 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 762376006386 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 762376006387 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 762376006388 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 762376006389 ligand binding site [chemical binding]; other site 762376006390 homodimer interface [polypeptide binding]; other site 762376006391 NAD(P) binding site [chemical binding]; other site 762376006392 trimer interface B [polypeptide binding]; other site 762376006393 trimer interface A [polypeptide binding]; other site 762376006394 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 762376006395 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376006396 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376006397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376006398 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376006399 dimerization interface [polypeptide binding]; other site 762376006400 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 762376006401 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 762376006402 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376006403 putative glutathione S-transferase; Provisional; Region: PRK10357 762376006404 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 762376006405 putative C-terminal domain interface [polypeptide binding]; other site 762376006406 putative GSH binding site (G-site) [chemical binding]; other site 762376006407 putative dimer interface [polypeptide binding]; other site 762376006408 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 762376006409 dimer interface [polypeptide binding]; other site 762376006410 N-terminal domain interface [polypeptide binding]; other site 762376006411 putative substrate binding pocket (H-site) [chemical binding]; other site 762376006412 adenylosuccinate lyase; Provisional; Region: PRK09285 762376006413 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 762376006414 tetramer interface [polypeptide binding]; other site 762376006415 active site 762376006416 Cytochrome C' Region: Cytochrom_C_2; pfam01322 762376006417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376006418 S-adenosylmethionine binding site [chemical binding]; other site 762376006419 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 762376006420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376006421 Coenzyme A binding pocket [chemical binding]; other site 762376006422 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 762376006423 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762376006424 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376006425 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376006426 metal binding site [ion binding]; metal-binding site 762376006427 active site 762376006428 I-site; other site 762376006429 aromatic amino acid exporter; Provisional; Region: PRK11689 762376006430 EamA-like transporter family; Region: EamA; pfam00892 762376006431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376006432 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 762376006433 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 762376006434 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 762376006435 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 762376006436 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 762376006437 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 762376006438 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 762376006439 putative active site [active] 762376006440 catalytic site [active] 762376006441 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 762376006442 putative active site [active] 762376006443 catalytic site [active] 762376006444 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 762376006445 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 762376006446 active site 762376006447 FMN binding site [chemical binding]; other site 762376006448 substrate binding site [chemical binding]; other site 762376006449 3Fe-4S cluster binding site [ion binding]; other site 762376006450 Sulphur transport; Region: Sulf_transp; pfam04143 762376006451 arsenical pump membrane protein; Provisional; Region: PRK15445 762376006452 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 762376006453 transmembrane helices; other site 762376006454 Predicted permeases [General function prediction only]; Region: COG0679 762376006455 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376006456 EamA-like transporter family; Region: EamA; pfam00892 762376006457 EamA-like transporter family; Region: EamA; pfam00892 762376006458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376006459 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762376006460 Coenzyme A binding pocket [chemical binding]; other site 762376006461 DTW domain; Region: DTW; cl01221 762376006462 ribonuclease R; Region: RNase_R; TIGR02063 762376006463 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762376006464 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762376006465 RNB domain; Region: RNB; pfam00773 762376006466 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 762376006467 RNA binding site [nucleotide binding]; other site 762376006468 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 762376006469 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 762376006470 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762376006471 hypothetical protein; Provisional; Region: PRK05939 762376006472 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376006473 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376006474 catalytic residue [active] 762376006475 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 762376006476 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 762376006477 IHF dimer interface [polypeptide binding]; other site 762376006478 IHF - DNA interface [nucleotide binding]; other site 762376006479 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 762376006480 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 762376006481 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 762376006482 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 762376006483 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 762376006484 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376006485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376006486 active site 762376006487 phosphorylation site [posttranslational modification] 762376006488 intermolecular recognition site; other site 762376006489 dimerization interface [polypeptide binding]; other site 762376006490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376006491 DNA binding site [nucleotide binding] 762376006492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376006493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376006494 dimer interface [polypeptide binding]; other site 762376006495 phosphorylation site [posttranslational modification] 762376006496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376006497 ATP binding site [chemical binding]; other site 762376006498 Mg2+ binding site [ion binding]; other site 762376006499 G-X-G motif; other site 762376006500 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 762376006501 potassium uptake protein; Region: kup; TIGR00794 762376006502 argininosuccinate synthase; Validated; Region: PRK05370 762376006503 argininosuccinate synthase; Provisional; Region: PRK13820 762376006504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376006505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376006506 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376006507 putative dimerization interface [polypeptide binding]; other site 762376006508 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 762376006509 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 762376006510 active site 762376006511 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376006512 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762376006513 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762376006514 ornithine carbamoyltransferase; Provisional; Region: PRK00779 762376006515 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762376006516 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762376006517 acetylornithine aminotransferase; Provisional; Region: PRK02627 762376006518 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376006519 inhibitor-cofactor binding pocket; inhibition site 762376006520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376006521 catalytic residue [active] 762376006522 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 762376006523 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376006524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376006525 DNA-binding site [nucleotide binding]; DNA binding site 762376006526 FCD domain; Region: FCD; pfam07729 762376006527 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376006528 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376006529 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376006530 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376006531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376006532 dimer interface [polypeptide binding]; other site 762376006533 conserved gate region; other site 762376006534 putative PBP binding loops; other site 762376006535 ABC-ATPase subunit interface; other site 762376006536 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762376006537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376006538 dimer interface [polypeptide binding]; other site 762376006539 conserved gate region; other site 762376006540 putative PBP binding loops; other site 762376006541 ABC-ATPase subunit interface; other site 762376006542 cytosine deaminase; Provisional; Region: PRK05985 762376006543 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 762376006544 active site 762376006545 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 762376006546 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376006547 active site 762376006548 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376006549 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376006550 Walker A/P-loop; other site 762376006551 ATP binding site [chemical binding]; other site 762376006552 Q-loop/lid; other site 762376006553 ABC transporter signature motif; other site 762376006554 Walker B; other site 762376006555 D-loop; other site 762376006556 H-loop/switch region; other site 762376006557 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376006558 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376006559 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376006560 Walker A/P-loop; other site 762376006561 ATP binding site [chemical binding]; other site 762376006562 Q-loop/lid; other site 762376006563 ABC transporter signature motif; other site 762376006564 Walker B; other site 762376006565 D-loop; other site 762376006566 H-loop/switch region; other site 762376006567 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376006568 DctM-like transporters; Region: DctM; pfam06808 762376006569 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 762376006570 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 762376006571 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 762376006572 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 762376006573 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 762376006574 FtsX-like permease family; Region: FtsX; pfam02687 762376006575 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 762376006576 apolar tunnel; other site 762376006577 heme binding site [chemical binding]; other site 762376006578 dimerization interface [polypeptide binding]; other site 762376006579 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 762376006580 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 762376006581 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 762376006582 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762376006583 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 762376006584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376006585 Walker A/P-loop; other site 762376006586 ATP binding site [chemical binding]; other site 762376006587 Q-loop/lid; other site 762376006588 ABC transporter signature motif; other site 762376006589 Walker B; other site 762376006590 D-loop; other site 762376006591 H-loop/switch region; other site 762376006592 TOBE domain; Region: TOBE_2; pfam08402 762376006593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376006594 dimer interface [polypeptide binding]; other site 762376006595 conserved gate region; other site 762376006596 putative PBP binding loops; other site 762376006597 ABC-ATPase subunit interface; other site 762376006598 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 762376006599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376006600 dimer interface [polypeptide binding]; other site 762376006601 conserved gate region; other site 762376006602 putative PBP binding loops; other site 762376006603 ABC-ATPase subunit interface; other site 762376006604 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 762376006605 ArsC family; Region: ArsC; pfam03960 762376006606 putative catalytic residues [active] 762376006607 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 762376006608 active site 762376006609 DNA binding site [nucleotide binding] 762376006610 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; pfam10707 762376006611 RmuC family; Region: RmuC; pfam02646 762376006612 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376006613 Amidase; Region: Amidase; cl11426 762376006614 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 762376006615 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376006616 active site 762376006617 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376006618 active site 762376006619 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 762376006620 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762376006621 active site 762376006622 dimer interface [polypeptide binding]; other site 762376006623 transcriptional regulator PhoU; Provisional; Region: PRK11115 762376006624 PhoU domain; Region: PhoU; pfam01895 762376006625 PhoU domain; Region: PhoU; pfam01895 762376006626 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 762376006627 Phosphoesterase family; Region: Phosphoesterase; pfam04185 762376006628 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376006629 oxidative damage protection protein; Provisional; Region: PRK05408 762376006630 N-acetylglutamate synthase; Validated; Region: PRK05279 762376006631 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 762376006632 putative feedback inhibition sensing region; other site 762376006633 putative nucleotide binding site [chemical binding]; other site 762376006634 putative substrate binding site [chemical binding]; other site 762376006635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376006636 Coenzyme A binding pocket [chemical binding]; other site 762376006637 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 762376006638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376006639 ATP binding site [chemical binding]; other site 762376006640 putative Mg++ binding site [ion binding]; other site 762376006641 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376006642 nucleotide binding region [chemical binding]; other site 762376006643 ATP-binding site [chemical binding]; other site 762376006644 Helicase associated domain (HA2); Region: HA2; pfam04408 762376006645 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 762376006646 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 762376006647 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 762376006648 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 762376006649 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 762376006650 putative active site [active] 762376006651 putative PHP Thumb interface [polypeptide binding]; other site 762376006652 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 762376006653 generic binding surface I; other site 762376006654 generic binding surface II; other site 762376006655 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376006656 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376006657 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 762376006658 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 762376006659 putative active site [active] 762376006660 putative metal binding site [ion binding]; other site 762376006661 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762376006662 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 762376006663 putative metal binding site; other site 762376006664 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376006665 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376006666 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 762376006667 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 762376006668 putative active site [active] 762376006669 putative metal binding site [ion binding]; other site 762376006670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376006671 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376006672 Flagellin N-methylase; Region: FliB; cl00497 762376006673 Uncharacterized conserved protein [Function unknown]; Region: COG1434 762376006674 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 762376006675 putative active site [active] 762376006676 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 762376006677 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762376006678 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762376006679 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 762376006680 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762376006681 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 762376006682 Walker A/P-loop; other site 762376006683 ATP binding site [chemical binding]; other site 762376006684 Q-loop/lid; other site 762376006685 ABC transporter signature motif; other site 762376006686 Walker B; other site 762376006687 D-loop; other site 762376006688 H-loop/switch region; other site 762376006689 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 762376006690 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 762376006691 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 762376006692 TrkA-N domain; Region: TrkA_N; pfam02254 762376006693 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376006694 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376006695 metal binding site [ion binding]; metal-binding site 762376006696 active site 762376006697 I-site; other site 762376006698 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 762376006699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376006700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376006701 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376006702 putative dimerization interface [polypeptide binding]; other site 762376006703 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 762376006704 DctM-like transporters; Region: DctM; pfam06808 762376006705 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 762376006706 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 762376006707 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 762376006708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376006709 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762376006710 NAD(P) binding site [chemical binding]; other site 762376006711 active site 762376006712 Helix-turn-helix domain; Region: HTH_17; pfam12728 762376006713 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 762376006714 DNA methylase; Region: N6_N4_Mtase; cl17433 762376006715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376006716 AAA domain; Region: AAA_23; pfam13476 762376006717 Walker A/P-loop; other site 762376006718 ATP binding site [chemical binding]; other site 762376006719 recombination associated protein; Reviewed; Region: rdgC; PRK00321 762376006720 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 762376006721 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 762376006722 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 762376006723 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 762376006724 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376006725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376006726 non-specific DNA binding site [nucleotide binding]; other site 762376006727 salt bridge; other site 762376006728 sequence-specific DNA binding site [nucleotide binding]; other site 762376006729 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 762376006730 Catalytic site [active] 762376006731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376006732 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376006733 non-specific DNA binding site [nucleotide binding]; other site 762376006734 salt bridge; other site 762376006735 sequence-specific DNA binding site [nucleotide binding]; other site 762376006736 HNH endonuclease; Region: HNH_3; pfam13392 762376006737 Nuclease-related domain; Region: NERD; pfam08378 762376006738 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 762376006739 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 762376006740 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 762376006741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 762376006742 Terminase-like family; Region: Terminase_6; pfam03237 762376006743 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 762376006744 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 762376006745 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 762376006746 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 762376006747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 762376006748 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 762376006749 Calicivirus minor structural protein; Region: Calici_MSP; pfam05752 762376006750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 762376006751 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 762376006752 LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cl06998 762376006753 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 762376006754 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 762376006755 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 762376006756 Phage-related minor tail protein [Function unknown]; Region: COG5281 762376006757 tape measure domain; Region: tape_meas_nterm; TIGR02675 762376006758 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 762376006759 Baseplate J-like protein; Region: Baseplate_J; cl01294 762376006760 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 762376006761 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376006762 active site 762376006763 DNA binding site [nucleotide binding] 762376006764 Int/Topo IB signature motif; other site 762376006765 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 762376006766 catalytic residue [active] 762376006767 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 762376006768 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 762376006769 active site 762376006770 Int/Topo IB signature motif; other site 762376006771 ribonuclease G; Provisional; Region: PRK11712 762376006772 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 762376006773 homodimer interface [polypeptide binding]; other site 762376006774 oligonucleotide binding site [chemical binding]; other site 762376006775 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 762376006776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376006777 active site 762376006778 phosphorylation site [posttranslational modification] 762376006779 intermolecular recognition site; other site 762376006780 dimerization interface [polypeptide binding]; other site 762376006781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376006782 Walker A motif; other site 762376006783 ATP binding site [chemical binding]; other site 762376006784 Walker B motif; other site 762376006785 arginine finger; other site 762376006786 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762376006787 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 762376006788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376006789 phosphorylation site [posttranslational modification] 762376006790 dimer interface [polypeptide binding]; other site 762376006791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376006792 ATP binding site [chemical binding]; other site 762376006793 Mg2+ binding site [ion binding]; other site 762376006794 G-X-G motif; other site 762376006795 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 762376006796 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 762376006797 Maf-like protein; Region: Maf; pfam02545 762376006798 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 762376006799 active site 762376006800 dimer interface [polypeptide binding]; other site 762376006801 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 762376006802 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 762376006803 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 762376006804 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 762376006805 active site 762376006806 (T/H)XGH motif; other site 762376006807 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 762376006808 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 762376006809 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 762376006810 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 762376006811 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 762376006812 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 762376006813 hypothetical protein; Validated; Region: PRK00110 762376006814 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762376006815 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 762376006816 Walker A motif; other site 762376006817 ATP binding site [chemical binding]; other site 762376006818 tartrate dehydrogenase; Region: TTC; TIGR02089 762376006819 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 762376006820 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 762376006821 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376006822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376006823 putative substrate translocation pore; other site 762376006824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376006825 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 762376006826 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376006827 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376006828 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 762376006829 MarR family; Region: MarR_2; cl17246 762376006830 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376006831 Predicted permeases [General function prediction only]; Region: RarD; COG2962 762376006832 EamA-like transporter family; Region: EamA; pfam00892 762376006833 EamA-like transporter family; Region: EamA; pfam00892 762376006834 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 762376006835 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 762376006836 NADP binding site [chemical binding]; other site 762376006837 dimer interface [polypeptide binding]; other site 762376006838 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 762376006839 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376006840 NAD(P) binding site [chemical binding]; other site 762376006841 catalytic residues [active] 762376006842 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 762376006843 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 762376006844 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376006845 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762376006846 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 762376006847 Cytochrome c; Region: Cytochrom_C; pfam00034 762376006848 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376006849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376006850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 762376006851 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 762376006852 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 762376006853 metal binding triad; other site 762376006854 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 762376006855 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 762376006856 metal binding triad; other site 762376006857 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 762376006858 TIGR02099 family protein; Region: TIGR02099 762376006859 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 762376006860 transcription termination factor Rho; Provisional; Region: rho; PRK09376 762376006861 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 762376006862 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 762376006863 RNA binding site [nucleotide binding]; other site 762376006864 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 762376006865 multimer interface [polypeptide binding]; other site 762376006866 Walker A motif; other site 762376006867 ATP binding site [chemical binding]; other site 762376006868 Walker B motif; other site 762376006869 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762376006870 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762376006871 catalytic residues [active] 762376006872 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 762376006873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376006874 ATP binding site [chemical binding]; other site 762376006875 Mg2+ binding site [ion binding]; other site 762376006876 G-X-G motif; other site 762376006877 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 762376006878 anchoring element; other site 762376006879 dimer interface [polypeptide binding]; other site 762376006880 ATP binding site [chemical binding]; other site 762376006881 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 762376006882 active site 762376006883 metal binding site [ion binding]; metal-binding site 762376006884 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762376006885 M penetrans paralogue family 26; Region: MpPF26; pfam07666 762376006886 YcxB-like protein; Region: YcxB; pfam14317 762376006887 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 762376006888 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 762376006889 CAP-like domain; other site 762376006890 active site 762376006891 primary dimer interface [polypeptide binding]; other site 762376006892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376006893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376006894 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 762376006895 Predicted membrane protein [Function unknown]; Region: COG2311 762376006896 Protein of unknown function (DUF418); Region: DUF418; pfam04235 762376006897 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 762376006898 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 762376006899 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 762376006900 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 762376006901 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 762376006902 hypothetical protein; Provisional; Region: PRK07483 762376006903 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376006904 inhibitor-cofactor binding pocket; inhibition site 762376006905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376006906 catalytic residue [active] 762376006907 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376006908 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 762376006909 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 762376006910 putative active site [active] 762376006911 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376006912 MarR family; Region: MarR; pfam01047 762376006913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376006914 Coenzyme A binding pocket [chemical binding]; other site 762376006915 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 762376006916 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376006917 inhibitor-cofactor binding pocket; inhibition site 762376006918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376006919 catalytic residue [active] 762376006920 Ectoine synthase; Region: Ectoine_synth; pfam06339 762376006921 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 762376006922 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 762376006923 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 762376006924 MOSC domain; Region: MOSC; pfam03473 762376006925 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376006926 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376006927 active site 762376006928 multidrug efflux system protein; Provisional; Region: PRK11431 762376006929 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 762376006930 tetramerization interface [polypeptide binding]; other site 762376006931 active site 762376006932 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 762376006933 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376006934 catalytic loop [active] 762376006935 iron binding site [ion binding]; other site 762376006936 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 762376006937 FAD binding pocket [chemical binding]; other site 762376006938 FAD binding motif [chemical binding]; other site 762376006939 phosphate binding motif [ion binding]; other site 762376006940 beta-alpha-beta structure motif; other site 762376006941 NAD binding pocket [chemical binding]; other site 762376006942 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 762376006943 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762376006944 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762376006945 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 762376006946 VirB7 interaction site; other site 762376006947 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 762376006948 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 762376006949 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 762376006950 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 762376006951 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762376006952 Walker A motif; other site 762376006953 ATP binding site [chemical binding]; other site 762376006954 Walker B motif; other site 762376006955 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 762376006956 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 762376006957 motif 1; other site 762376006958 active site 762376006959 motif 2; other site 762376006960 motif 3; other site 762376006961 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 762376006962 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 762376006963 CPxP motif; other site 762376006964 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 762376006965 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 762376006966 RimM N-terminal domain; Region: RimM; pfam01782 762376006967 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 762376006968 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 762376006969 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376006970 active site 762376006971 HIGH motif; other site 762376006972 nucleotide binding site [chemical binding]; other site 762376006973 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 762376006974 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 762376006975 active site 762376006976 KMSKS motif; other site 762376006977 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 762376006978 tRNA binding surface [nucleotide binding]; other site 762376006979 anticodon binding site; other site 762376006980 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 762376006981 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 762376006982 active site 762376006983 multimer interface [polypeptide binding]; other site 762376006984 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 762376006985 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 762376006986 FeS/SAM binding site; other site 762376006987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376006988 non-specific DNA binding site [nucleotide binding]; other site 762376006989 salt bridge; other site 762376006990 sequence-specific DNA binding site [nucleotide binding]; other site 762376006991 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 762376006992 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 762376006993 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 762376006994 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 762376006995 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 762376006996 dimer interface [polypeptide binding]; other site 762376006997 motif 1; other site 762376006998 active site 762376006999 motif 2; other site 762376007000 motif 3; other site 762376007001 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 762376007002 anticodon binding site; other site 762376007003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 762376007004 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 762376007005 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 762376007006 Trp docking motif [polypeptide binding]; other site 762376007007 active site 762376007008 GTP-binding protein Der; Reviewed; Region: PRK00093 762376007009 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 762376007010 G1 box; other site 762376007011 GTP/Mg2+ binding site [chemical binding]; other site 762376007012 Switch I region; other site 762376007013 G2 box; other site 762376007014 Switch II region; other site 762376007015 G3 box; other site 762376007016 G4 box; other site 762376007017 G5 box; other site 762376007018 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 762376007019 G1 box; other site 762376007020 GTP/Mg2+ binding site [chemical binding]; other site 762376007021 Switch I region; other site 762376007022 G2 box; other site 762376007023 G3 box; other site 762376007024 Switch II region; other site 762376007025 G4 box; other site 762376007026 G5 box; other site 762376007027 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 762376007028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376007029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376007030 homodimer interface [polypeptide binding]; other site 762376007031 catalytic residue [active] 762376007032 bacterial Hfq-like; Region: Hfq; cd01716 762376007033 hexamer interface [polypeptide binding]; other site 762376007034 Sm1 motif; other site 762376007035 RNA binding site [nucleotide binding]; other site 762376007036 Sm2 motif; other site 762376007037 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 762376007038 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 762376007039 HflX GTPase family; Region: HflX; cd01878 762376007040 G1 box; other site 762376007041 GTP/Mg2+ binding site [chemical binding]; other site 762376007042 Switch I region; other site 762376007043 G2 box; other site 762376007044 G3 box; other site 762376007045 Switch II region; other site 762376007046 G4 box; other site 762376007047 G5 box; other site 762376007048 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 762376007049 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 762376007050 HflK protein; Region: hflK; TIGR01933 762376007051 HflC protein; Region: hflC; TIGR01932 762376007052 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 762376007053 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 762376007054 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 762376007055 dimer interface [polypeptide binding]; other site 762376007056 motif 1; other site 762376007057 active site 762376007058 motif 2; other site 762376007059 motif 3; other site 762376007060 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 762376007061 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 762376007062 GDP-binding site [chemical binding]; other site 762376007063 ACT binding site; other site 762376007064 IMP binding site; other site 762376007065 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 762376007066 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762376007067 active site 762376007068 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 762376007069 DNA primase, catalytic core; Region: dnaG; TIGR01391 762376007070 CHC2 zinc finger; Region: zf-CHC2; pfam01807 762376007071 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 762376007072 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 762376007073 active site 762376007074 metal binding site [ion binding]; metal-binding site 762376007075 interdomain interaction site; other site 762376007076 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 762376007077 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 762376007078 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 762376007079 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 762376007080 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 762376007081 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 762376007082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376007083 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 762376007084 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376007085 DNA binding residues [nucleotide binding] 762376007086 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 762376007087 putative amphipathic alpha helix; other site 762376007088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376007090 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376007091 putative effector binding pocket; other site 762376007092 dimerization interface [polypeptide binding]; other site 762376007093 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376007094 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376007095 thiolase; Provisional; Region: PRK06158 762376007096 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376007097 active site 762376007098 Coenzyme A transferase; Region: CoA_trans; cl17247 762376007099 Coenzyme A transferase; Region: CoA_trans; cl17247 762376007100 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 762376007101 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 762376007102 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 762376007103 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376007104 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762376007105 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 762376007106 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762376007107 carboxyltransferase (CT) interaction site; other site 762376007108 biotinylation site [posttranslational modification]; other site 762376007109 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376007110 short chain dehydrogenase; Provisional; Region: PRK07791 762376007111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376007112 NAD(P) binding site [chemical binding]; other site 762376007113 active site 762376007114 enoyl-CoA hydratase; Region: PLN02864 762376007115 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376007116 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 762376007117 dimer interaction site [polypeptide binding]; other site 762376007118 substrate-binding tunnel; other site 762376007119 active site 762376007120 catalytic site [active] 762376007121 substrate binding site [chemical binding]; other site 762376007122 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 762376007123 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 762376007124 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 762376007125 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 762376007126 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 762376007127 phosphopeptide binding site; other site 762376007128 Type II/IV secretion system protein; Region: T2SE; pfam00437 762376007129 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 762376007130 ATP binding site [chemical binding]; other site 762376007131 Walker A motif; other site 762376007132 hexamer interface [polypeptide binding]; other site 762376007133 Walker B motif; other site 762376007134 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 762376007135 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 762376007136 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 762376007137 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 762376007138 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 762376007139 putative active site [active] 762376007140 putative substrate binding site [chemical binding]; other site 762376007141 ATP binding site [chemical binding]; other site 762376007142 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 762376007143 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 762376007144 FMN binding site [chemical binding]; other site 762376007145 active site 762376007146 catalytic residues [active] 762376007147 substrate binding site [chemical binding]; other site 762376007148 FOG: CBS domain [General function prediction only]; Region: COG0517 762376007149 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625 762376007150 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 762376007151 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 762376007152 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 762376007153 Uncharacterized conserved protein [Function unknown]; Region: COG0397 762376007154 hypothetical protein; Validated; Region: PRK00029 762376007155 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376007156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376007157 active site 762376007158 phosphorylation site [posttranslational modification] 762376007159 intermolecular recognition site; other site 762376007160 dimerization interface [polypeptide binding]; other site 762376007161 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 762376007162 DNA binding site [nucleotide binding] 762376007163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376007164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376007165 dimer interface [polypeptide binding]; other site 762376007166 phosphorylation site [posttranslational modification] 762376007167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376007168 ATP binding site [chemical binding]; other site 762376007169 Mg2+ binding site [ion binding]; other site 762376007170 G-X-G motif; other site 762376007171 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376007172 metal binding site [ion binding]; metal-binding site 762376007173 active site 762376007174 I-site; other site 762376007175 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376007176 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376007177 metal binding site [ion binding]; metal-binding site 762376007178 active site 762376007179 I-site; other site 762376007180 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376007181 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 762376007182 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 762376007183 Tetramer interface [polypeptide binding]; other site 762376007184 active site 762376007185 FMN-binding site [chemical binding]; other site 762376007186 Peptidase family M48; Region: Peptidase_M48; pfam01435 762376007187 regulatory protein CsrD; Provisional; Region: PRK11059 762376007188 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376007189 metal binding site [ion binding]; metal-binding site 762376007190 active site 762376007191 I-site; other site 762376007192 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376007193 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 762376007194 VCBS repeat; Region: VCBS_repeat; TIGR01965 762376007195 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 762376007196 Putative Ig domain; Region: He_PIG; pfam05345 762376007197 VCBS repeat; Region: VCBS_repeat; TIGR01965 762376007198 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 762376007199 Putative Ig domain; Region: He_PIG; pfam05345 762376007200 VCBS repeat; Region: VCBS_repeat; TIGR01965 762376007201 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 762376007202 metal ion-dependent adhesion site (MIDAS); other site 762376007203 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 762376007204 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 762376007205 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 762376007206 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 762376007207 Putative Ig domain; Region: He_PIG; pfam05345 762376007208 VCBS repeat; Region: VCBS_repeat; TIGR01965 762376007209 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 762376007210 VCBS repeat; Region: VCBS_repeat; TIGR01965 762376007211 VCBS repeat; Region: VCBS_repeat; TIGR01965 762376007212 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 762376007213 metal ion-dependent adhesion site (MIDAS); other site 762376007214 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 762376007215 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 762376007216 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376007217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376007218 DNA binding residues [nucleotide binding] 762376007219 dimerization interface [polypeptide binding]; other site 762376007220 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 762376007221 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376007222 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376007223 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 762376007224 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 762376007225 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762376007226 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 762376007227 Walker A/P-loop; other site 762376007228 ATP binding site [chemical binding]; other site 762376007229 Q-loop/lid; other site 762376007230 ABC transporter signature motif; other site 762376007231 Walker B; other site 762376007232 D-loop; other site 762376007233 H-loop/switch region; other site 762376007234 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 762376007235 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 762376007236 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 762376007237 substrate binding site [chemical binding]; other site 762376007238 ligand binding site [chemical binding]; other site 762376007239 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 762376007240 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 762376007241 substrate binding site [chemical binding]; other site 762376007242 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 762376007243 tartrate dehydrogenase; Region: TTC; TIGR02089 762376007244 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 762376007245 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 762376007246 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762376007247 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 762376007248 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 762376007249 dimerization interface 3.5A [polypeptide binding]; other site 762376007250 active site 762376007251 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 762376007252 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 762376007253 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 762376007254 active site 762376007255 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376007256 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376007257 metal binding site [ion binding]; metal-binding site 762376007258 active site 762376007259 I-site; other site 762376007260 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376007261 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 762376007262 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376007263 dimer interface [polypeptide binding]; other site 762376007264 putative CheW interface [polypeptide binding]; other site 762376007265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 762376007266 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 762376007267 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 762376007268 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 762376007269 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 762376007270 DctM-like transporters; Region: DctM; pfam06808 762376007271 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 762376007272 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762376007273 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762376007274 DNA binding site [nucleotide binding] 762376007275 domain linker motif; other site 762376007276 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 762376007277 putative dimerization interface [polypeptide binding]; other site 762376007278 putative ligand binding site [chemical binding]; other site 762376007279 Cupin domain; Region: Cupin_2; cl17218 762376007280 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376007281 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376007282 Walker A/P-loop; other site 762376007283 ATP binding site [chemical binding]; other site 762376007284 Q-loop/lid; other site 762376007285 ABC transporter signature motif; other site 762376007286 Walker B; other site 762376007287 D-loop; other site 762376007288 H-loop/switch region; other site 762376007289 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376007290 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376007291 Walker A/P-loop; other site 762376007292 ATP binding site [chemical binding]; other site 762376007293 Q-loop/lid; other site 762376007294 ABC transporter signature motif; other site 762376007295 Walker B; other site 762376007296 D-loop; other site 762376007297 H-loop/switch region; other site 762376007298 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376007299 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376007300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376007301 dimer interface [polypeptide binding]; other site 762376007302 conserved gate region; other site 762376007303 putative PBP binding loops; other site 762376007304 ABC-ATPase subunit interface; other site 762376007305 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376007306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376007307 dimer interface [polypeptide binding]; other site 762376007308 conserved gate region; other site 762376007309 putative PBP binding loops; other site 762376007310 ABC-ATPase subunit interface; other site 762376007311 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376007312 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 762376007313 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376007314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376007315 DNA-binding site [nucleotide binding]; DNA binding site 762376007316 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376007317 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 762376007318 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 762376007319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762376007320 FeS/SAM binding site; other site 762376007321 HemN C-terminal domain; Region: HemN_C; pfam06969 762376007322 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376007323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376007324 active site 762376007325 phosphorylation site [posttranslational modification] 762376007326 intermolecular recognition site; other site 762376007327 dimerization interface [polypeptide binding]; other site 762376007328 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376007329 DNA binding residues [nucleotide binding] 762376007330 dimerization interface [polypeptide binding]; other site 762376007331 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 762376007332 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 762376007333 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 762376007334 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 762376007335 active site 762376007336 dimer interface [polypeptide binding]; other site 762376007337 motif 1; other site 762376007338 motif 2; other site 762376007339 motif 3; other site 762376007340 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 762376007341 anticodon binding site; other site 762376007342 translation initiation factor IF-3; Region: infC; TIGR00168 762376007343 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 762376007344 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 762376007345 glutathione synthetase; Provisional; Region: PRK05246 762376007346 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 762376007347 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 762376007348 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 762376007349 active pocket/dimerization site; other site 762376007350 active site 762376007351 phosphorylation site [posttranslational modification] 762376007352 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 762376007353 dimerization domain swap beta strand [polypeptide binding]; other site 762376007354 regulatory protein interface [polypeptide binding]; other site 762376007355 active site 762376007356 regulatory phosphorylation site [posttranslational modification]; other site 762376007357 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 762376007358 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 762376007359 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 762376007360 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 762376007361 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 762376007362 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 762376007363 Nitrogen regulatory protein P-II; Region: P-II; smart00938 762376007364 Membrane fusogenic activity; Region: BMFP; pfam04380 762376007365 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 762376007366 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 762376007367 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 762376007368 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 762376007369 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 762376007370 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 762376007371 23S rRNA binding site [nucleotide binding]; other site 762376007372 L21 binding site [polypeptide binding]; other site 762376007373 L13 binding site [polypeptide binding]; other site 762376007374 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 762376007375 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 762376007376 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 762376007377 dimer interface [polypeptide binding]; other site 762376007378 motif 1; other site 762376007379 active site 762376007380 motif 2; other site 762376007381 motif 3; other site 762376007382 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 762376007383 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 762376007384 putative tRNA-binding site [nucleotide binding]; other site 762376007385 B3/4 domain; Region: B3_4; pfam03483 762376007386 tRNA synthetase B5 domain; Region: B5; smart00874 762376007387 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 762376007388 dimer interface [polypeptide binding]; other site 762376007389 motif 1; other site 762376007390 motif 3; other site 762376007391 motif 2; other site 762376007392 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 762376007393 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 762376007394 IHF - DNA interface [nucleotide binding]; other site 762376007395 IHF dimer interface [polypeptide binding]; other site 762376007396 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 762376007397 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 762376007398 DNA binding residues [nucleotide binding] 762376007399 putative acetyltransferase; Provisional; Region: PRK10514 762376007400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762376007401 Rhomboid family; Region: Rhomboid; pfam01694 762376007402 short chain dehydrogenase; Provisional; Region: PRK07478 762376007403 classical (c) SDRs; Region: SDR_c; cd05233 762376007404 NAD(P) binding site [chemical binding]; other site 762376007405 active site 762376007406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376007407 S-adenosylmethionine binding site [chemical binding]; other site 762376007408 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 762376007409 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 762376007410 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376007411 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376007412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376007413 dihydroxy-acid dehydratase; Validated; Region: PRK06131 762376007414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376007416 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 762376007417 putative dimerization interface [polypeptide binding]; other site 762376007418 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762376007419 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 762376007420 putative ligand binding site [chemical binding]; other site 762376007421 NAD binding site [chemical binding]; other site 762376007422 catalytic site [active] 762376007423 DoxX-like family; Region: DoxX_2; pfam13564 762376007424 Predicted transcriptional regulators [Transcription]; Region: COG1733 762376007425 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762376007426 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 762376007427 putative acetyltransferase; Provisional; Region: PRK03624 762376007428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376007429 Coenzyme A binding pocket [chemical binding]; other site 762376007430 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 762376007431 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 762376007432 active site 762376007433 Zn binding site [ion binding]; other site 762376007434 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376007435 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376007436 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 762376007437 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 762376007438 putative active site [active] 762376007439 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 762376007440 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376007441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376007442 putative DNA binding site [nucleotide binding]; other site 762376007443 putative Zn2+ binding site [ion binding]; other site 762376007444 AsnC family; Region: AsnC_trans_reg; pfam01037 762376007445 EamA-like transporter family; Region: EamA; pfam00892 762376007446 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376007447 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376007448 dimerization interface [polypeptide binding]; other site 762376007449 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 762376007450 putative active cleft [active] 762376007451 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376007452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376007453 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376007454 dimerization interface [polypeptide binding]; other site 762376007455 substrate binding pocket [chemical binding]; other site 762376007456 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376007457 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 762376007458 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 762376007459 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376007460 substrate binding pocket [chemical binding]; other site 762376007461 membrane-bound complex binding site; other site 762376007462 hinge residues; other site 762376007463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376007464 dimer interface [polypeptide binding]; other site 762376007465 ABC-ATPase subunit interface; other site 762376007466 putative PBP binding loops; other site 762376007467 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376007468 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762376007469 Walker A/P-loop; other site 762376007470 ATP binding site [chemical binding]; other site 762376007471 Q-loop/lid; other site 762376007472 ABC transporter signature motif; other site 762376007473 Walker B; other site 762376007474 D-loop; other site 762376007475 H-loop/switch region; other site 762376007476 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 762376007477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376007478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007479 dimerization interface [polypeptide binding]; other site 762376007480 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 762376007481 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 762376007482 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 762376007483 iron-sulfur cluster [ion binding]; other site 762376007484 [2Fe-2S] cluster binding site [ion binding]; other site 762376007485 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762376007486 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 762376007487 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 762376007488 Walker A/P-loop; other site 762376007489 ATP binding site [chemical binding]; other site 762376007490 Q-loop/lid; other site 762376007491 ABC transporter signature motif; other site 762376007492 Walker B; other site 762376007493 D-loop; other site 762376007494 H-loop/switch region; other site 762376007495 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762376007496 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762376007497 active site 762376007498 catalytic tetrad [active] 762376007499 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376007500 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 762376007501 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 762376007502 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 762376007503 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 762376007504 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376007505 active site 762376007506 metal binding site [ion binding]; metal-binding site 762376007507 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 762376007508 Transglycosylase; Region: Transgly; pfam00912 762376007509 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 762376007510 Cupin domain; Region: Cupin_2; pfam07883 762376007511 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376007512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376007513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376007514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376007515 putative substrate translocation pore; other site 762376007516 PgaD-like protein; Region: PgaD; pfam13994 762376007517 N-glycosyltransferase; Provisional; Region: PRK11204 762376007518 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 762376007519 DXD motif; other site 762376007520 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 762376007521 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 762376007522 putative active site [active] 762376007523 putative metal binding site [ion binding]; other site 762376007524 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 762376007525 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376007526 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376007527 metal binding site [ion binding]; metal-binding site 762376007528 active site 762376007529 I-site; other site 762376007530 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 762376007531 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762376007532 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376007533 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762376007534 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376007535 active site 762376007536 metal binding site [ion binding]; metal-binding site 762376007537 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 762376007538 putative switch regulator; other site 762376007539 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376007540 non-specific DNA interactions [nucleotide binding]; other site 762376007541 DNA binding site [nucleotide binding] 762376007542 sequence specific DNA binding site [nucleotide binding]; other site 762376007543 putative cAMP binding site [chemical binding]; other site 762376007544 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376007545 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376007546 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 762376007547 CoenzymeA binding site [chemical binding]; other site 762376007548 subunit interaction site [polypeptide binding]; other site 762376007549 PHB binding site; other site 762376007550 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 762376007551 active site 762376007552 DNA polymerase IV; Validated; Region: PRK02406 762376007553 DNA binding site [nucleotide binding] 762376007554 Yqey-like protein; Region: YqeY; pfam09424 762376007555 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 762376007556 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 762376007557 dimer interface [polypeptide binding]; other site 762376007558 active site 762376007559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376007560 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 762376007561 NAD(P) binding site [chemical binding]; other site 762376007562 active site 762376007563 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 762376007564 putative active site 1 [active] 762376007565 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 762376007566 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 762376007567 active site 762376007568 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 762376007569 Predicted exporter [General function prediction only]; Region: COG4258 762376007570 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 762376007571 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 762376007572 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 762376007573 active site 762376007574 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 762376007575 putative acyl-acceptor binding pocket; other site 762376007576 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762376007577 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762376007578 active site 762376007579 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376007580 AMP-binding enzyme; Region: AMP-binding; pfam00501 762376007581 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376007582 AMP binding site [chemical binding]; other site 762376007583 active site 762376007584 acyl-activating enzyme (AAE) consensus motif; other site 762376007585 acyl-activating enzyme (AAE) consensus motif; other site 762376007586 CoA binding site [chemical binding]; other site 762376007587 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 762376007588 active site 2 [active] 762376007589 dimer interface [polypeptide binding]; other site 762376007590 Predicted membrane protein [Function unknown]; Region: COG4648 762376007591 acyl carrier protein; Provisional; Region: PRK05350 762376007592 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762376007593 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 762376007594 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762376007595 putative acyl-acceptor binding pocket; other site 762376007596 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 762376007597 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 762376007598 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 762376007599 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 762376007600 heme-binding site [chemical binding]; other site 762376007601 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 762376007602 FAD binding pocket [chemical binding]; other site 762376007603 FAD binding motif [chemical binding]; other site 762376007604 phosphate binding motif [ion binding]; other site 762376007605 beta-alpha-beta structure motif; other site 762376007606 NAD binding pocket [chemical binding]; other site 762376007607 Heme binding pocket [chemical binding]; other site 762376007608 Predicted transcriptional regulator [Transcription]; Region: COG1959 762376007609 Transcriptional regulator; Region: Rrf2; cl17282 762376007610 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 762376007611 EamA-like transporter family; Region: EamA; pfam00892 762376007612 EamA-like transporter family; Region: EamA; pfam00892 762376007613 Proline dehydrogenase; Region: Pro_dh; cl03282 762376007614 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 762376007615 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 762376007616 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762376007617 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376007618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376007619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007620 dimerization interface [polypeptide binding]; other site 762376007621 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 762376007622 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376007623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376007624 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376007625 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 762376007626 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376007627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007628 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 762376007629 putative effector binding pocket; other site 762376007630 putative dimerization interface [polypeptide binding]; other site 762376007631 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376007632 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 762376007633 putative C-terminal domain interface [polypeptide binding]; other site 762376007634 putative GSH binding site (G-site) [chemical binding]; other site 762376007635 putative dimer interface [polypeptide binding]; other site 762376007636 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 762376007637 putative N-terminal domain interface [polypeptide binding]; other site 762376007638 putative dimer interface [polypeptide binding]; other site 762376007639 putative substrate binding pocket (H-site) [chemical binding]; other site 762376007640 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 762376007641 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 762376007642 Predicted transcriptional regulators [Transcription]; Region: COG1733 762376007643 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762376007644 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 762376007645 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 762376007646 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376007647 active site 762376007648 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 762376007649 acyl-CoA synthetase; Validated; Region: PRK08162 762376007650 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 762376007651 acyl-activating enzyme (AAE) consensus motif; other site 762376007652 putative active site [active] 762376007653 AMP binding site [chemical binding]; other site 762376007654 putative CoA binding site [chemical binding]; other site 762376007655 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376007656 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376007657 ligand binding site [chemical binding]; other site 762376007658 flexible hinge region; other site 762376007659 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 762376007660 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376007661 MarR family; Region: MarR_2; pfam12802 762376007662 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 762376007663 Uncharacterized conserved protein [Function unknown]; Region: COG1262 762376007664 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 762376007665 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376007666 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376007667 ligand binding site [chemical binding]; other site 762376007668 flexible hinge region; other site 762376007669 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 762376007670 putative switch regulator; other site 762376007671 non-specific DNA interactions [nucleotide binding]; other site 762376007672 DNA binding site [nucleotide binding] 762376007673 sequence specific DNA binding site [nucleotide binding]; other site 762376007674 putative cAMP binding site [chemical binding]; other site 762376007675 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 762376007676 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 762376007677 Multicopper oxidase; Region: Cu-oxidase; pfam00394 762376007678 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 762376007679 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 762376007680 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 762376007681 dimer interface [polypeptide binding]; other site 762376007682 TPP-binding site [chemical binding]; other site 762376007683 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376007684 glutathione reductase; Validated; Region: PRK06116 762376007685 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376007686 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376007687 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376007688 Protein of unknown function DUF72; Region: DUF72; pfam01904 762376007689 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376007690 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376007691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376007692 DNA-binding site [nucleotide binding]; DNA binding site 762376007693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376007694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376007695 homodimer interface [polypeptide binding]; other site 762376007696 catalytic residue [active] 762376007697 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376007698 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762376007699 EamA-like transporter family; Region: EamA; cl17759 762376007700 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376007701 EamA-like transporter family; Region: EamA; pfam00892 762376007702 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762376007703 catalytic residues [active] 762376007704 allantoate amidohydrolase; Reviewed; Region: PRK12890 762376007705 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762376007706 active site 762376007707 metal binding site [ion binding]; metal-binding site 762376007708 dimer interface [polypeptide binding]; other site 762376007709 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376007711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376007712 dimerization interface [polypeptide binding]; other site 762376007713 enoyl-CoA hydratase; Provisional; Region: PRK05995 762376007714 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376007715 substrate binding site [chemical binding]; other site 762376007716 oxyanion hole (OAH) forming residues; other site 762376007717 trimer interface [polypeptide binding]; other site 762376007718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376007719 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376007720 NAD(P) binding site [chemical binding]; other site 762376007721 active site 762376007722 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376007723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376007724 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 762376007725 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 762376007726 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 762376007727 active site 762376007728 acyl-activating enzyme (AAE) consensus motif; other site 762376007729 putative CoA binding site [chemical binding]; other site 762376007730 AMP binding site [chemical binding]; other site 762376007731 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 762376007732 active site 762376007733 substrate-binding site [chemical binding]; other site 762376007734 metal-binding site [ion binding] 762376007735 GTP binding site [chemical binding]; other site 762376007736 Methyltransferase domain; Region: Methyltransf_23; pfam13489 762376007737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376007738 S-adenosylmethionine binding site [chemical binding]; other site 762376007739 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 762376007740 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376007741 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376007742 Walker A/P-loop; other site 762376007743 ATP binding site [chemical binding]; other site 762376007744 Q-loop/lid; other site 762376007745 ABC transporter signature motif; other site 762376007746 Walker B; other site 762376007747 D-loop; other site 762376007748 H-loop/switch region; other site 762376007749 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376007750 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376007751 Walker A/P-loop; other site 762376007752 ATP binding site [chemical binding]; other site 762376007753 Q-loop/lid; other site 762376007754 ABC transporter signature motif; other site 762376007755 Walker B; other site 762376007756 D-loop; other site 762376007757 H-loop/switch region; other site 762376007758 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376007759 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376007760 TM-ABC transporter signature motif; other site 762376007761 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376007762 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376007763 TM-ABC transporter signature motif; other site 762376007764 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376007765 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376007766 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376007767 Amidase; Region: Amidase; pfam01425 762376007768 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376007769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376007770 DNA-binding site [nucleotide binding]; DNA binding site 762376007771 FCD domain; Region: FCD; pfam07729 762376007772 Amino acid synthesis; Region: AA_synth; pfam06684 762376007773 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376007774 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376007775 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762376007776 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376007777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376007778 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376007779 putative dimerization interface [polypeptide binding]; other site 762376007780 Protein of unknown function (DUF1629); Region: DUF1629; pfam07791 762376007781 short chain dehydrogenase; Provisional; Region: PRK08265 762376007782 classical (c) SDRs; Region: SDR_c; cd05233 762376007783 NAD(P) binding site [chemical binding]; other site 762376007784 active site 762376007785 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 762376007786 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 762376007787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762376007788 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 762376007789 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376007790 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376007791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376007792 putative Zn2+ binding site [ion binding]; other site 762376007793 putative DNA binding site [nucleotide binding]; other site 762376007794 Pirin-related protein [General function prediction only]; Region: COG1741 762376007795 Pirin; Region: Pirin; pfam02678 762376007796 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 762376007797 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 762376007798 putative active site [active] 762376007799 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 762376007800 4Fe-4S binding domain; Region: Fer4; pfam00037 762376007801 tetrathionate reductase subunit C; Provisional; Region: PRK14992 762376007802 tetrathionate reductase subunit A; Provisional; Region: PRK14991 762376007803 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762376007804 molybdopterin cofactor binding site; other site 762376007805 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762376007806 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 762376007807 putative molybdopterin cofactor binding site; other site 762376007808 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 762376007809 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 762376007810 TPR motif; other site 762376007811 Tetratricopeptide repeats; Region: TPR; smart00028 762376007812 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 762376007813 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 762376007814 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762376007815 catalytic residues [active] 762376007816 central insert; other site 762376007817 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 762376007818 CcmE; Region: CcmE; pfam03100 762376007819 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 762376007820 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 762376007821 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 762376007822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376007823 Walker A/P-loop; other site 762376007824 ATP binding site [chemical binding]; other site 762376007825 Q-loop/lid; other site 762376007826 ABC transporter signature motif; other site 762376007827 Walker B; other site 762376007828 D-loop; other site 762376007829 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 762376007830 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 762376007831 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 762376007832 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 762376007833 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 762376007834 [4Fe-4S] binding site [ion binding]; other site 762376007835 molybdopterin cofactor binding site; other site 762376007836 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 762376007837 molybdopterin cofactor binding site; other site 762376007838 NapD protein; Region: NapD; pfam03927 762376007839 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 762376007840 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376007842 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376007843 putative effector binding pocket; other site 762376007844 dimerization interface [polypeptide binding]; other site 762376007845 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 762376007846 trimer interface [polypeptide binding]; other site 762376007847 Haemagglutinin; Region: HIM; pfam05662 762376007848 Haemagglutinin; Region: HIM; pfam05662 762376007849 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 762376007850 trimer interface [polypeptide binding]; other site 762376007851 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 762376007852 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 762376007853 trimer interface [polypeptide binding]; other site 762376007854 YadA-like C-terminal region; Region: YadA; pfam03895 762376007855 protein-export membrane protein SecD; Region: secD; TIGR01129 762376007856 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 762376007857 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 762376007858 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376007859 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376007860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376007862 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376007863 putative dimerization interface [polypeptide binding]; other site 762376007864 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376007865 MarR family; Region: MarR_2; pfam12802 762376007866 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 762376007867 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 762376007868 XdhC Rossmann domain; Region: XdhC_C; pfam13478 762376007869 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 762376007870 Ligand binding site; other site 762376007871 metal-binding site 762376007872 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 762376007873 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376007874 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376007875 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 762376007876 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 762376007877 Isochorismatase family; Region: Isochorismatase; pfam00857 762376007878 catalytic triad [active] 762376007879 substrate binding site [chemical binding]; other site 762376007880 domain interfaces; other site 762376007881 conserved cis-peptide bond; other site 762376007882 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 762376007883 inter-subunit interface; other site 762376007884 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376007885 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 762376007886 iron-sulfur cluster [ion binding]; other site 762376007887 [2Fe-2S] cluster binding site [ion binding]; other site 762376007888 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 762376007889 putative alpha subunit interface [polypeptide binding]; other site 762376007890 putative active site [active] 762376007891 putative substrate binding site [chemical binding]; other site 762376007892 Fe binding site [ion binding]; other site 762376007893 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 762376007894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376007895 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 762376007896 [2Fe-2S] cluster binding site [ion binding]; other site 762376007897 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 762376007898 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 762376007899 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 762376007900 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 762376007901 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762376007902 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 762376007903 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 762376007904 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376007905 catalytic loop [active] 762376007906 iron binding site [ion binding]; other site 762376007907 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 762376007908 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 762376007909 putative hydrophobic ligand binding site [chemical binding]; other site 762376007910 NMT1/THI5 like; Region: NMT1; pfam09084 762376007911 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 762376007912 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376007913 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762376007914 Walker A/P-loop; other site 762376007915 ATP binding site [chemical binding]; other site 762376007916 Q-loop/lid; other site 762376007917 ABC transporter signature motif; other site 762376007918 Walker B; other site 762376007919 D-loop; other site 762376007920 H-loop/switch region; other site 762376007921 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376007922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376007923 dimer interface [polypeptide binding]; other site 762376007924 conserved gate region; other site 762376007925 putative PBP binding loops; other site 762376007926 ABC-ATPase subunit interface; other site 762376007927 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 762376007928 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 762376007929 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 762376007930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376007931 S-adenosylmethionine binding site [chemical binding]; other site 762376007932 Methyltransferase domain; Region: Methyltransf_23; pfam13489 762376007933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376007934 S-adenosylmethionine binding site [chemical binding]; other site 762376007935 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376007936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376007937 non-specific DNA binding site [nucleotide binding]; other site 762376007938 salt bridge; other site 762376007939 sequence-specific DNA binding site [nucleotide binding]; other site 762376007940 HipA N-terminal domain; Region: Couple_hipA; pfam13657 762376007941 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 762376007942 HipA-like N-terminal domain; Region: HipA_N; pfam07805 762376007943 HipA-like C-terminal domain; Region: HipA_C; pfam07804 762376007944 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376007945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376007946 DNA-binding site [nucleotide binding]; DNA binding site 762376007947 FCD domain; Region: FCD; pfam07729 762376007948 dihydroxy-acid dehydratase; Validated; Region: PRK06131 762376007949 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376007950 RNase II stability modulator; Provisional; Region: PRK10060 762376007951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376007952 putative active site [active] 762376007953 heme pocket [chemical binding]; other site 762376007954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376007955 metal binding site [ion binding]; metal-binding site 762376007956 active site 762376007957 I-site; other site 762376007958 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376007959 enoyl-CoA hydratase; Validated; Region: PRK08788 762376007960 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376007961 substrate binding site [chemical binding]; other site 762376007962 oxyanion hole (OAH) forming residues; other site 762376007963 trimer interface [polypeptide binding]; other site 762376007964 short chain dehydrogenase; Provisional; Region: PRK12937 762376007965 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 762376007966 NADP binding site [chemical binding]; other site 762376007967 homodimer interface [polypeptide binding]; other site 762376007968 active site 762376007969 substrate binding site [chemical binding]; other site 762376007970 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376007972 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 762376007973 putative effector binding pocket; other site 762376007974 putative dimerization interface [polypeptide binding]; other site 762376007975 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 762376007976 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 762376007977 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 762376007978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376007979 putative substrate translocation pore; other site 762376007980 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376007981 Amidase; Region: Amidase; pfam01425 762376007982 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376007983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376007984 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376007985 dimerization interface [polypeptide binding]; other site 762376007986 substrate binding pocket [chemical binding]; other site 762376007987 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 762376007988 nudix motif; other site 762376007989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376007990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376007991 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376007992 dimerization interface [polypeptide binding]; other site 762376007993 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 762376007994 active site 762376007995 intersubunit interface [polypeptide binding]; other site 762376007996 Zn2+ binding site [ion binding]; other site 762376007997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376007998 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376007999 putative substrate translocation pore; other site 762376008000 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 762376008001 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 762376008002 putative catalytic residue [active] 762376008003 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 762376008004 active sites [active] 762376008005 tetramer interface [polypeptide binding]; other site 762376008006 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 762376008007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376008008 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376008009 putative substrate translocation pore; other site 762376008010 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376008011 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376008012 active site 762376008013 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376008014 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376008015 active site 762376008016 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376008017 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376008018 urocanate hydratase; Provisional; Region: PRK05414 762376008019 Protein of unknown function (DUF917); Region: DUF917; pfam06032 762376008020 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376008021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008022 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376008023 putative dimerization interface [polypeptide binding]; other site 762376008024 allantoinase; Provisional; Region: PRK06189 762376008025 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376008026 active site 762376008027 allantoate amidohydrolase; Reviewed; Region: PRK12890 762376008028 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762376008029 active site 762376008030 metal binding site [ion binding]; metal-binding site 762376008031 dimer interface [polypeptide binding]; other site 762376008032 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376008033 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376008034 putative ligand binding site [chemical binding]; other site 762376008035 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376008036 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376008037 DNA-binding site [nucleotide binding]; DNA binding site 762376008038 UTRA domain; Region: UTRA; pfam07702 762376008039 acyl-CoA synthetase; Validated; Region: PRK06164 762376008040 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376008041 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376008042 AMP binding site [chemical binding]; other site 762376008043 active site 762376008044 acyl-activating enzyme (AAE) consensus motif; other site 762376008045 CoA binding site [chemical binding]; other site 762376008046 Putative cyclase; Region: Cyclase; pfam04199 762376008047 Putative cyclase; Region: Cyclase; cl00814 762376008048 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376008049 short chain dehydrogenase; Provisional; Region: PRK07577 762376008050 classical (c) SDRs; Region: SDR_c; cd05233 762376008051 NAD(P) binding site [chemical binding]; other site 762376008052 active site 762376008053 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 762376008054 conserved cys residue [active] 762376008055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376008056 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 762376008057 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 762376008058 conserved cys residue [active] 762376008059 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376008060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376008061 putative DNA binding site [nucleotide binding]; other site 762376008062 putative Zn2+ binding site [ion binding]; other site 762376008063 AsnC family; Region: AsnC_trans_reg; pfam01037 762376008064 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376008065 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762376008066 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 762376008067 Walker A/P-loop; other site 762376008068 ATP binding site [chemical binding]; other site 762376008069 Q-loop/lid; other site 762376008070 ABC transporter signature motif; other site 762376008071 Walker B; other site 762376008072 D-loop; other site 762376008073 H-loop/switch region; other site 762376008074 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376008075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376008076 DNA-binding site [nucleotide binding]; DNA binding site 762376008077 FCD domain; Region: FCD; pfam07729 762376008078 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762376008079 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 762376008080 active site 762376008081 metal binding site [ion binding]; metal-binding site 762376008082 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 762376008083 active site 762376008084 metal binding site [ion binding]; metal-binding site 762376008085 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 762376008086 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 762376008087 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 762376008088 NAD binding site [chemical binding]; other site 762376008089 catalytic residues [active] 762376008090 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376008091 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 762376008092 putative ligand binding site [chemical binding]; other site 762376008093 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376008094 TM-ABC transporter signature motif; other site 762376008095 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376008096 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376008097 TM-ABC transporter signature motif; other site 762376008098 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376008099 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376008100 Walker A/P-loop; other site 762376008101 ATP binding site [chemical binding]; other site 762376008102 Q-loop/lid; other site 762376008103 ABC transporter signature motif; other site 762376008104 Walker B; other site 762376008105 D-loop; other site 762376008106 H-loop/switch region; other site 762376008107 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376008108 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376008109 Walker A/P-loop; other site 762376008110 ATP binding site [chemical binding]; other site 762376008111 Q-loop/lid; other site 762376008112 ABC transporter signature motif; other site 762376008113 Walker B; other site 762376008114 D-loop; other site 762376008115 H-loop/switch region; other site 762376008116 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376008117 classical (c) SDRs; Region: SDR_c; cd05233 762376008118 NAD(P) binding site [chemical binding]; other site 762376008119 active site 762376008120 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762376008121 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376008122 dimerization interface [polypeptide binding]; other site 762376008123 putative DNA binding site [nucleotide binding]; other site 762376008124 putative Zn2+ binding site [ion binding]; other site 762376008125 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 762376008126 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762376008127 putative NAD(P) binding site [chemical binding]; other site 762376008128 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376008129 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376008130 N-terminal plug; other site 762376008131 ligand-binding site [chemical binding]; other site 762376008132 fec operon regulator FecR; Reviewed; Region: PRK09774 762376008133 FecR protein; Region: FecR; pfam04773 762376008134 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376008135 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376008136 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 762376008137 DNA binding residues [nucleotide binding] 762376008138 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376008139 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376008140 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376008141 N-terminal plug; other site 762376008142 ligand-binding site [chemical binding]; other site 762376008143 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376008144 FecR protein; Region: FecR; pfam04773 762376008145 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376008146 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376008147 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376008148 DNA binding residues [nucleotide binding] 762376008149 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 762376008150 methionine synthase; Provisional; Region: PRK01207 762376008151 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 762376008152 substrate binding site [chemical binding]; other site 762376008153 THF binding site; other site 762376008154 zinc-binding site [ion binding]; other site 762376008155 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 762376008156 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 762376008157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008158 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 762376008159 putative dimerization interface [polypeptide binding]; other site 762376008160 AAA domain; Region: AAA_11; pfam13086 762376008161 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376008162 ATP binding site [chemical binding]; other site 762376008163 AAA domain; Region: AAA_12; pfam13087 762376008164 Uncharacterized integral membrane protein [Function unknown]; Region: COG5594 762376008165 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762376008166 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 762376008167 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762376008168 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 762376008169 active site 762376008170 FMN binding site [chemical binding]; other site 762376008171 substrate binding site [chemical binding]; other site 762376008172 putative catalytic residue [active] 762376008173 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376008174 homotrimer interaction site [polypeptide binding]; other site 762376008175 putative active site [active] 762376008176 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376008177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008178 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376008179 dimerization interface [polypeptide binding]; other site 762376008180 substrate binding pocket [chemical binding]; other site 762376008181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376008182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376008183 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376008184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376008185 putative substrate translocation pore; other site 762376008186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376008187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008188 LysR substrate binding domain; Region: LysR_substrate; pfam03466 762376008189 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 762376008190 Penicillin amidase; Region: Penicil_amidase; pfam01804 762376008191 Penicillin G acylase (PGA) is the key enzyme in the industrial production of beta-lactam antibiotics. PGA hydrolyzes the side chain of penicillin G and related beta-lactam antibiotics releasing 6-amino penicillanic acid (6-APA), a building block in the...; Region: Ntn_PGA; cd03748 762376008192 active site 762376008193 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762376008194 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762376008195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376008196 Walker A/P-loop; other site 762376008197 ATP binding site [chemical binding]; other site 762376008198 Q-loop/lid; other site 762376008199 ABC transporter signature motif; other site 762376008200 Walker B; other site 762376008201 D-loop; other site 762376008202 H-loop/switch region; other site 762376008203 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762376008204 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762376008205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376008206 Walker A/P-loop; other site 762376008207 ATP binding site [chemical binding]; other site 762376008208 Q-loop/lid; other site 762376008209 ABC transporter signature motif; other site 762376008210 Walker B; other site 762376008211 D-loop; other site 762376008212 H-loop/switch region; other site 762376008213 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 762376008214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008216 dimerization interface [polypeptide binding]; other site 762376008217 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376008218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376008219 DNA-binding site [nucleotide binding]; DNA binding site 762376008220 FCD domain; Region: FCD; pfam07729 762376008221 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 762376008222 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376008223 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 762376008224 acyl-activating enzyme (AAE) consensus motif; other site 762376008225 acyl-activating enzyme (AAE) consensus motif; other site 762376008226 putative AMP binding site [chemical binding]; other site 762376008227 putative active site [active] 762376008228 putative CoA binding site [chemical binding]; other site 762376008229 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 762376008230 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376008231 active site 762376008232 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376008233 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376008234 Walker A/P-loop; other site 762376008235 ATP binding site [chemical binding]; other site 762376008236 Q-loop/lid; other site 762376008237 ABC transporter signature motif; other site 762376008238 Walker B; other site 762376008239 D-loop; other site 762376008240 H-loop/switch region; other site 762376008241 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376008242 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376008243 Walker A/P-loop; other site 762376008244 ATP binding site [chemical binding]; other site 762376008245 Q-loop/lid; other site 762376008246 ABC transporter signature motif; other site 762376008247 Walker B; other site 762376008248 D-loop; other site 762376008249 H-loop/switch region; other site 762376008250 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376008251 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376008252 TM-ABC transporter signature motif; other site 762376008253 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376008254 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376008255 TM-ABC transporter signature motif; other site 762376008256 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376008257 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376008258 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376008259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008261 dimerization interface [polypeptide binding]; other site 762376008262 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376008263 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376008264 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376008265 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376008266 active site 762376008267 catalytic site [active] 762376008268 N-formylglutamate amidohydrolase; Region: FGase; cl01522 762376008269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008270 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376008271 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376008272 putative effector binding pocket; other site 762376008273 dimerization interface [polypeptide binding]; other site 762376008274 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376008275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376008276 putative substrate translocation pore; other site 762376008277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376008278 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376008279 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 762376008280 inner membrane protein; Provisional; Region: PRK10995 762376008281 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 762376008282 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 762376008283 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 762376008284 active site 762376008285 non-prolyl cis peptide bond; other site 762376008286 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 762376008287 Na binding site [ion binding]; other site 762376008288 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 762376008289 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 762376008290 acyl-activating enzyme (AAE) consensus motif; other site 762376008291 putative AMP binding site [chemical binding]; other site 762376008292 putative active site [active] 762376008293 putative CoA binding site [chemical binding]; other site 762376008294 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376008295 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 762376008296 dimer interface [polypeptide binding]; other site 762376008297 active site 762376008298 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376008299 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376008300 putative ligand binding site [chemical binding]; other site 762376008301 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376008302 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008303 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008304 dimerization interface [polypeptide binding]; other site 762376008305 transcriptional regulator TraR; Provisional; Region: PRK13870 762376008306 Autoinducer binding domain; Region: Autoind_bind; pfam03472 762376008307 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376008308 DNA binding residues [nucleotide binding] 762376008309 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 762376008310 putative catalytic site [active] 762376008311 putative phosphate binding site [ion binding]; other site 762376008312 active site 762376008313 metal binding site A [ion binding]; metal-binding site 762376008314 DNA binding site [nucleotide binding] 762376008315 putative AP binding site [nucleotide binding]; other site 762376008316 putative metal binding site B [ion binding]; other site 762376008317 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 762376008318 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376008319 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376008320 MbtH-like protein; Region: MbtH; cl01279 762376008321 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 762376008322 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 762376008323 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 762376008324 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 762376008325 acyl-CoA synthetase; Validated; Region: PRK05850 762376008326 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 762376008327 acyl-activating enzyme (AAE) consensus motif; other site 762376008328 active site 762376008329 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 762376008330 Condensation domain; Region: Condensation; pfam00668 762376008331 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 762376008332 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 762376008333 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 762376008334 acyl-activating enzyme (AAE) consensus motif; other site 762376008335 AMP binding site [chemical binding]; other site 762376008336 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 762376008337 Condensation domain; Region: Condensation; pfam00668 762376008338 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 762376008339 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 762376008340 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 762376008341 acyl-activating enzyme (AAE) consensus motif; other site 762376008342 AMP binding site [chemical binding]; other site 762376008343 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 762376008344 Condensation domain; Region: Condensation; pfam00668 762376008345 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 762376008346 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 762376008347 Condensation domain; Region: Condensation; pfam00668 762376008348 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 762376008349 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 762376008350 acyl-activating enzyme (AAE) consensus motif; other site 762376008351 AMP binding site [chemical binding]; other site 762376008352 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 762376008353 Condensation domain; Region: Condensation; pfam00668 762376008354 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 762376008355 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 762376008356 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 762376008357 acyl-activating enzyme (AAE) consensus motif; other site 762376008358 AMP binding site [chemical binding]; other site 762376008359 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 762376008360 Condensation domain; Region: Condensation; pfam00668 762376008361 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 762376008362 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 762376008363 acyl-activating enzyme (AAE) consensus motif; other site 762376008364 AMP binding site [chemical binding]; other site 762376008365 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 762376008366 Thioesterase domain; Region: Thioesterase; pfam00975 762376008367 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376008368 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 762376008369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376008370 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 762376008371 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 762376008372 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 762376008373 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376008374 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376008375 N-terminal plug; other site 762376008376 ligand-binding site [chemical binding]; other site 762376008377 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376008378 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376008379 N-terminal plug; other site 762376008380 ligand-binding site [chemical binding]; other site 762376008381 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 762376008382 catalytic site [active] 762376008383 Penicillin amidase; Region: Penicil_amidase; pfam01804 762376008384 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 762376008385 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 762376008386 active site 762376008387 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 762376008388 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 762376008389 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 762376008390 Walker A/P-loop; other site 762376008391 ATP binding site [chemical binding]; other site 762376008392 Q-loop/lid; other site 762376008393 ABC transporter signature motif; other site 762376008394 Walker B; other site 762376008395 D-loop; other site 762376008396 H-loop/switch region; other site 762376008397 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 762376008398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376008399 NAD(P) binding site [chemical binding]; other site 762376008400 active site 762376008401 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376008402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376008403 DNA-binding site [nucleotide binding]; DNA binding site 762376008404 FCD domain; Region: FCD; pfam07729 762376008405 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376008406 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 762376008407 NAD(P) binding site [chemical binding]; other site 762376008408 catalytic residues [active] 762376008409 catalytic residues [active] 762376008410 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 762376008411 Lumazine binding domain; Region: Lum_binding; pfam00677 762376008412 Lumazine binding domain; Region: Lum_binding; pfam00677 762376008413 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 762376008414 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 762376008415 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376008416 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376008417 MlrC C-terminus; Region: MlrC_C; pfam07171 762376008418 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 762376008419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376008420 putative substrate translocation pore; other site 762376008421 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376008422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008424 dimerization interface [polypeptide binding]; other site 762376008425 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 762376008426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376008427 Coenzyme A binding pocket [chemical binding]; other site 762376008428 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762376008429 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376008430 Soluble P-type ATPase [General function prediction only]; Region: COG4087 762376008431 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 762376008432 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 762376008433 DNA binding residues [nucleotide binding] 762376008434 dimer interface [polypeptide binding]; other site 762376008435 putative metal binding site [ion binding]; other site 762376008436 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376008437 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376008438 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376008439 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376008440 DNA-binding site [nucleotide binding]; DNA binding site 762376008441 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376008442 enoyl-CoA hydratase; Provisional; Region: PRK06127 762376008443 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376008444 substrate binding site [chemical binding]; other site 762376008445 oxyanion hole (OAH) forming residues; other site 762376008446 trimer interface [polypeptide binding]; other site 762376008447 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376008448 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 762376008449 putative FMN binding site [chemical binding]; other site 762376008450 putative transposase OrfB; Reviewed; Region: PHA02517 762376008451 HTH-like domain; Region: HTH_21; pfam13276 762376008452 Integrase core domain; Region: rve; pfam00665 762376008453 Integrase core domain; Region: rve_2; pfam13333 762376008454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376008455 Helix-turn-helix domain; Region: HTH_28; pfam13518 762376008456 Helix-turn-helix domain; Region: HTH_28; pfam13518 762376008457 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 762376008458 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 762376008459 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762376008460 tetramer interface [polypeptide binding]; other site 762376008461 TPP-binding site [chemical binding]; other site 762376008462 heterodimer interface [polypeptide binding]; other site 762376008463 phosphorylation loop region [posttranslational modification] 762376008464 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762376008465 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762376008466 alpha subunit interface [polypeptide binding]; other site 762376008467 TPP binding site [chemical binding]; other site 762376008468 heterodimer interface [polypeptide binding]; other site 762376008469 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376008470 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376008471 E3 interaction surface; other site 762376008472 lipoyl attachment site [posttranslational modification]; other site 762376008473 e3 binding domain; Region: E3_binding; pfam02817 762376008474 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 762376008475 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762376008476 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 762376008477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376008478 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376008479 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376008480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008481 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376008482 dimerization interface [polypeptide binding]; other site 762376008483 substrate binding pocket [chemical binding]; other site 762376008484 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376008485 Amidase; Region: Amidase; cl11426 762376008486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376008487 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 762376008488 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376008489 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376008490 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376008491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008492 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376008493 putative dimerization interface [polypeptide binding]; other site 762376008494 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376008495 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376008496 active site 762376008497 catalytic site [active] 762376008498 The beta subunit of the Class III extradiol dioxygenase, 2-amino-5-chlorophenol 1,6-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 2-amino-5-chlorophenol; Region: 2A5CPDO_B; cd07372 762376008499 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 762376008500 putative active site [active] 762376008501 putative metal binding site [ion binding]; other site 762376008502 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 762376008503 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 762376008504 active site 762376008505 metal binding site [ion binding]; metal-binding site 762376008506 putative fumarate hydratase; Provisional; Region: PRK15392 762376008507 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 762376008508 Fumarase C-terminus; Region: Fumerase_C; pfam05683 762376008509 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376008510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376008511 putative substrate translocation pore; other site 762376008512 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 762376008513 maleylacetoacetate isomerase; Region: maiA; TIGR01262 762376008514 C-terminal domain interface [polypeptide binding]; other site 762376008515 GSH binding site (G-site) [chemical binding]; other site 762376008516 putative dimer interface [polypeptide binding]; other site 762376008517 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 762376008518 N-terminal domain interface [polypeptide binding]; other site 762376008519 substrate binding pocket (H-site) [chemical binding]; other site 762376008520 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376008521 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376008522 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762376008523 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 762376008524 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376008525 Zn binding site [ion binding]; other site 762376008526 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 762376008527 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 762376008528 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376008529 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376008530 DNA binding residues [nucleotide binding] 762376008531 dimerization interface [polypeptide binding]; other site 762376008532 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376008533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376008534 putative substrate translocation pore; other site 762376008535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376008536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008537 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 762376008538 putative effector binding pocket; other site 762376008539 putative dimerization interface [polypeptide binding]; other site 762376008540 argininosuccinate lyase; Provisional; Region: PRK00855 762376008541 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 762376008542 active sites [active] 762376008543 tetramer interface [polypeptide binding]; other site 762376008544 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 762376008545 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762376008546 NAD synthetase; Reviewed; Region: nadE; PRK02628 762376008547 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 762376008548 multimer interface [polypeptide binding]; other site 762376008549 active site 762376008550 catalytic triad [active] 762376008551 protein interface 1 [polypeptide binding]; other site 762376008552 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 762376008553 homodimer interface [polypeptide binding]; other site 762376008554 NAD binding pocket [chemical binding]; other site 762376008555 ATP binding pocket [chemical binding]; other site 762376008556 Mg binding site [ion binding]; other site 762376008557 active-site loop [active] 762376008558 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 762376008559 Nitrogen regulatory protein P-II; Region: P-II; smart00938 762376008560 type II secretion system protein F; Region: GspF; TIGR02120 762376008561 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 762376008562 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 762376008563 type II secretion system protein D; Region: type_II_gspD; TIGR02517 762376008564 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 762376008565 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 762376008566 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 762376008567 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 762376008568 type II secretion system protein E; Region: type_II_gspE; TIGR02533 762376008569 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 762376008570 Walker A motif; other site 762376008571 ATP binding site [chemical binding]; other site 762376008572 Walker B motif; other site 762376008573 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 762376008574 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 762376008575 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 762376008576 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 762376008577 GspL periplasmic domain; Region: GspL_C; cl14909 762376008578 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 762376008579 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 762376008580 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 762376008581 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 762376008582 Type II transport protein GspH; Region: GspH; pfam12019 762376008583 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 762376008584 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 762376008585 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 762376008586 Uncharacterized conserved protein [Function unknown]; Region: COG3379 762376008587 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 762376008588 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 762376008589 Phosphoesterase family; Region: Phosphoesterase; pfam04185 762376008590 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376008591 Domain of unknown function (DUF756); Region: DUF756; pfam05506 762376008592 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376008593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008594 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376008595 dimerization interface [polypeptide binding]; other site 762376008596 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 762376008597 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376008598 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 762376008599 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376008600 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376008601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376008602 dimer interface [polypeptide binding]; other site 762376008603 conserved gate region; other site 762376008604 putative PBP binding loops; other site 762376008605 ABC-ATPase subunit interface; other site 762376008606 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762376008607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376008608 dimer interface [polypeptide binding]; other site 762376008609 conserved gate region; other site 762376008610 putative PBP binding loops; other site 762376008611 ABC-ATPase subunit interface; other site 762376008612 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 762376008613 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376008614 Walker A/P-loop; other site 762376008615 ATP binding site [chemical binding]; other site 762376008616 Q-loop/lid; other site 762376008617 ABC transporter signature motif; other site 762376008618 Walker B; other site 762376008619 D-loop; other site 762376008620 H-loop/switch region; other site 762376008621 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376008622 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376008623 Walker A/P-loop; other site 762376008624 ATP binding site [chemical binding]; other site 762376008625 Q-loop/lid; other site 762376008626 ABC transporter signature motif; other site 762376008627 Walker B; other site 762376008628 D-loop; other site 762376008629 H-loop/switch region; other site 762376008630 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376008631 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376008632 YaeQ protein; Region: YaeQ; pfam07152 762376008633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376008634 PAS fold; Region: PAS_3; pfam08447 762376008635 putative active site [active] 762376008636 heme pocket [chemical binding]; other site 762376008637 PAS fold; Region: PAS_3; pfam08447 762376008638 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376008639 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376008640 metal binding site [ion binding]; metal-binding site 762376008641 active site 762376008642 I-site; other site 762376008643 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376008644 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376008645 DNA-binding site [nucleotide binding]; DNA binding site 762376008646 UTRA domain; Region: UTRA; pfam07702 762376008647 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376008648 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 762376008649 putative ligand binding site [chemical binding]; other site 762376008650 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376008651 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376008652 TM-ABC transporter signature motif; other site 762376008653 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376008654 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376008655 TM-ABC transporter signature motif; other site 762376008656 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376008657 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376008658 Walker A/P-loop; other site 762376008659 ATP binding site [chemical binding]; other site 762376008660 Q-loop/lid; other site 762376008661 ABC transporter signature motif; other site 762376008662 Walker B; other site 762376008663 D-loop; other site 762376008664 H-loop/switch region; other site 762376008665 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376008666 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376008667 Walker A/P-loop; other site 762376008668 ATP binding site [chemical binding]; other site 762376008669 Q-loop/lid; other site 762376008670 ABC transporter signature motif; other site 762376008671 Walker B; other site 762376008672 D-loop; other site 762376008673 H-loop/switch region; other site 762376008674 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 762376008675 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 762376008676 substrate binding site [chemical binding]; other site 762376008677 ligand binding site [chemical binding]; other site 762376008678 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 762376008679 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 762376008680 substrate binding site [chemical binding]; other site 762376008681 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 762376008682 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 762376008683 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 762376008684 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 762376008685 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 762376008686 Isochorismatase family; Region: Isochorismatase; pfam00857 762376008687 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 762376008688 catalytic triad [active] 762376008689 conserved cis-peptide bond; other site 762376008690 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 762376008691 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 762376008692 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762376008693 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 762376008694 tetramer interface [polypeptide binding]; other site 762376008695 active site 762376008696 Mg2+/Mn2+ binding site [ion binding]; other site 762376008697 Chorismate lyase; Region: Chor_lyase; cl01230 762376008698 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376008699 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 762376008700 putative active site [active] 762376008701 catalytic triad [active] 762376008702 putative dimer interface [polypeptide binding]; other site 762376008703 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376008704 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 762376008705 putative ligand binding site [chemical binding]; other site 762376008706 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376008707 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376008708 TM-ABC transporter signature motif; other site 762376008709 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376008710 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376008711 TM-ABC transporter signature motif; other site 762376008712 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376008713 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376008714 Walker A/P-loop; other site 762376008715 ATP binding site [chemical binding]; other site 762376008716 Q-loop/lid; other site 762376008717 ABC transporter signature motif; other site 762376008718 Walker B; other site 762376008719 D-loop; other site 762376008720 H-loop/switch region; other site 762376008721 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376008722 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376008723 Walker A/P-loop; other site 762376008724 ATP binding site [chemical binding]; other site 762376008725 Q-loop/lid; other site 762376008726 ABC transporter signature motif; other site 762376008727 Walker B; other site 762376008728 D-loop; other site 762376008729 H-loop/switch region; other site 762376008730 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376008731 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 762376008732 ligand binding site [chemical binding]; other site 762376008733 regulator interaction site; other site 762376008734 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 762376008735 ANTAR domain; Region: ANTAR; pfam03861 762376008736 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376008737 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376008738 MlrC C-terminus; Region: MlrC_C; pfam07171 762376008739 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 762376008740 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376008741 RNA binding surface [nucleotide binding]; other site 762376008742 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 762376008743 active site 762376008744 transcriptional regulator; Provisional; Region: PRK10632 762376008745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376008746 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376008747 putative effector binding pocket; other site 762376008748 dimerization interface [polypeptide binding]; other site 762376008749 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 762376008750 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376008751 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376008752 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 762376008753 Protein export membrane protein; Region: SecD_SecF; cl14618 762376008754 Protein export membrane protein; Region: SecD_SecF; cl14618 762376008755 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 762376008756 Predicted membrane protein [Function unknown]; Region: COG2261 762376008757 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 762376008758 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 762376008759 Cu(I) binding site [ion binding]; other site 762376008760 Methyltransferase domain; Region: Methyltransf_23; pfam13489 762376008761 Methyltransferase domain; Region: Methyltransf_11; pfam08241 762376008762 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 762376008763 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 762376008764 active site 762376008765 Zn binding site [ion binding]; other site 762376008766 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 762376008767 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 762376008768 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 762376008769 homodimer interface [polypeptide binding]; other site 762376008770 NADP binding site [chemical binding]; other site 762376008771 substrate binding site [chemical binding]; other site 762376008772 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 762376008773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376008774 active site 762376008775 phosphorylation site [posttranslational modification] 762376008776 intermolecular recognition site; other site 762376008777 dimerization interface [polypeptide binding]; other site 762376008778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376008779 DNA binding residues [nucleotide binding] 762376008780 dimerization interface [polypeptide binding]; other site 762376008781 PAS domain S-box; Region: sensory_box; TIGR00229 762376008782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376008783 putative active site [active] 762376008784 heme pocket [chemical binding]; other site 762376008785 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 762376008786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376008787 dimer interface [polypeptide binding]; other site 762376008788 phosphorylation site [posttranslational modification] 762376008789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376008790 ATP binding site [chemical binding]; other site 762376008791 Mg2+ binding site [ion binding]; other site 762376008792 G-X-G motif; other site 762376008793 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 762376008794 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 762376008795 dimer interface [polypeptide binding]; other site 762376008796 TPP-binding site [chemical binding]; other site 762376008797 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 762376008798 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376008799 E3 interaction surface; other site 762376008800 lipoyl attachment site [posttranslational modification]; other site 762376008801 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376008802 E3 interaction surface; other site 762376008803 lipoyl attachment site [posttranslational modification]; other site 762376008804 e3 binding domain; Region: E3_binding; pfam02817 762376008805 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 762376008806 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762376008807 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376008808 E3 interaction surface; other site 762376008809 lipoyl attachment site [posttranslational modification]; other site 762376008810 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 762376008811 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762376008812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376008813 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376008814 Putative motility protein; Region: YjfB_motility; pfam14070 762376008815 Helix-turn-helix domain; Region: HTH_37; pfam13744 762376008816 sequence-specific DNA binding site [nucleotide binding]; other site 762376008817 salt bridge; other site 762376008818 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 762376008819 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 762376008820 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 762376008821 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 762376008822 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376008823 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 762376008824 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376008825 DNA binding residues [nucleotide binding] 762376008826 transcriptional activator FlhD; Provisional; Region: PRK02909 762376008827 transcriptional activator FlhC; Provisional; Region: PRK12722 762376008828 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 762376008829 flagellar motor protein MotA; Validated; Region: PRK09110 762376008830 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 762376008831 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 762376008832 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376008833 ligand binding site [chemical binding]; other site 762376008834 Response regulator receiver domain; Region: Response_reg; pfam00072 762376008835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376008836 active site 762376008837 phosphorylation site [posttranslational modification] 762376008838 intermolecular recognition site; other site 762376008839 dimerization interface [polypeptide binding]; other site 762376008840 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 762376008841 putative binding surface; other site 762376008842 active site 762376008843 CheY binding; Region: CheY-binding; pfam09078 762376008844 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 762376008845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376008846 ATP binding site [chemical binding]; other site 762376008847 Mg2+ binding site [ion binding]; other site 762376008848 G-X-G motif; other site 762376008849 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 762376008850 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 762376008851 putative CheA interaction surface; other site 762376008852 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 762376008853 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 762376008854 dimer interface [polypeptide binding]; other site 762376008855 ligand binding site [chemical binding]; other site 762376008856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376008857 dimerization interface [polypeptide binding]; other site 762376008858 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376008859 dimer interface [polypeptide binding]; other site 762376008860 putative CheW interface [polypeptide binding]; other site 762376008861 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 762376008862 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 762376008863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376008864 S-adenosylmethionine binding site [chemical binding]; other site 762376008865 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 762376008866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376008867 active site 762376008868 phosphorylation site [posttranslational modification] 762376008869 intermolecular recognition site; other site 762376008870 dimerization interface [polypeptide binding]; other site 762376008871 CheB methylesterase; Region: CheB_methylest; pfam01339 762376008872 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 762376008873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376008874 active site 762376008875 phosphorylation site [posttranslational modification] 762376008876 intermolecular recognition site; other site 762376008877 dimerization interface [polypeptide binding]; other site 762376008878 chemotaxis regulator CheZ; Provisional; Region: PRK11166 762376008879 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376008880 dimer interface [polypeptide binding]; other site 762376008881 putative CheW interface [polypeptide binding]; other site 762376008882 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 762376008883 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 762376008884 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 762376008885 FHIPEP family; Region: FHIPEP; pfam00771 762376008886 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 762376008887 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762376008888 FlgN protein; Region: FlgN; pfam05130 762376008889 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 762376008890 SAF-like; Region: SAF_2; pfam13144 762376008891 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 762376008892 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 762376008893 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 762376008894 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 762376008895 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 762376008896 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 762376008897 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK12633 762376008898 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 762376008899 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 762376008900 flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637 762376008901 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 762376008902 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 762376008903 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 762376008904 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 762376008905 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 762376008906 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 762376008907 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 762376008908 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 762376008909 Flagellar L-ring protein; Region: FlgH; cl17277 762376008910 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 762376008911 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 762376008912 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 762376008913 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12713 762376008914 Rod binding protein; Region: Rod-binding; cl01626 762376008915 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 762376008916 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 762376008917 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 762376008918 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 762376008919 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 762376008920 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 762376008921 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 762376008922 dimer interface [polypeptide binding]; other site 762376008923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376008924 dimerization interface [polypeptide binding]; other site 762376008925 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376008926 dimer interface [polypeptide binding]; other site 762376008927 putative CheW interface [polypeptide binding]; other site 762376008928 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 762376008929 dimer interface [polypeptide binding]; other site 762376008930 ligand binding site [chemical binding]; other site 762376008931 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376008932 dimerization interface [polypeptide binding]; other site 762376008933 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762376008934 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376008935 dimer interface [polypeptide binding]; other site 762376008936 putative CheW interface [polypeptide binding]; other site 762376008937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376008938 dimerization interface [polypeptide binding]; other site 762376008939 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762376008940 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376008941 dimer interface [polypeptide binding]; other site 762376008942 putative CheW interface [polypeptide binding]; other site 762376008943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376008944 PAS fold; Region: PAS_3; pfam08447 762376008945 putative active site [active] 762376008946 heme pocket [chemical binding]; other site 762376008947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376008948 dimerization interface [polypeptide binding]; other site 762376008949 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762376008950 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376008951 dimer interface [polypeptide binding]; other site 762376008952 putative CheW interface [polypeptide binding]; other site 762376008953 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 762376008954 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 762376008955 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 762376008956 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 762376008957 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 762376008958 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 762376008959 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 762376008960 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 762376008961 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 762376008962 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 762376008963 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 762376008964 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 762376008965 Walker A motif/ATP binding site; other site 762376008966 Walker B motif; other site 762376008967 flagellar assembly protein H; Validated; Region: fliH; PRK05687 762376008968 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 762376008969 Flagellar assembly protein FliH; Region: FliH; pfam02108 762376008970 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 762376008971 FliG C-terminal domain; Region: FliG_C; pfam01706 762376008972 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 762376008973 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 762376008974 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 762376008975 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 762376008976 Flagellar regulator YcgR; Region: YcgR; pfam07317 762376008977 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 762376008978 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 762376008979 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 762376008980 Flagellar protein FliT; Region: FliT; pfam05400 762376008981 Flagellar protein FliS; Region: FliS; cl00654 762376008982 flagellar capping protein; Reviewed; Region: fliD; PRK08032 762376008983 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 762376008984 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 762376008985 FlaG protein; Region: FlaG; pfam03646 762376008986 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376008987 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376008988 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376008989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376008990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376008991 active site 762376008992 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376008993 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376008994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376008995 Cupin domain; Region: Cupin_2; pfam07883 762376008996 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 762376008997 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762376008998 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762376008999 Sporulation related domain; Region: SPOR; pfam05036 762376009000 Colicin V production protein; Region: Colicin_V; pfam02674 762376009001 amidophosphoribosyltransferase; Provisional; Region: PRK09246 762376009002 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 762376009003 active site 762376009004 tetramer interface [polypeptide binding]; other site 762376009005 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762376009006 active site 762376009007 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 762376009008 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 762376009009 MarC family integral membrane protein; Region: MarC; cl00919 762376009010 PII uridylyl-transferase; Provisional; Region: PRK03059 762376009011 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 762376009012 metal binding triad; other site 762376009013 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 762376009014 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762376009015 Zn2+ binding site [ion binding]; other site 762376009016 Mg2+ binding site [ion binding]; other site 762376009017 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 762376009018 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 762376009019 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 762376009020 active site 762376009021 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 762376009022 rRNA interaction site [nucleotide binding]; other site 762376009023 S8 interaction site; other site 762376009024 putative laminin-1 binding site; other site 762376009025 elongation factor Ts; Provisional; Region: tsf; PRK09377 762376009026 UBA/TS-N domain; Region: UBA; pfam00627 762376009027 Elongation factor TS; Region: EF_TS; pfam00889 762376009028 Elongation factor TS; Region: EF_TS; pfam00889 762376009029 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 762376009030 putative nucleotide binding site [chemical binding]; other site 762376009031 uridine monophosphate binding site [chemical binding]; other site 762376009032 homohexameric interface [polypeptide binding]; other site 762376009033 ribosome recycling factor; Reviewed; Region: frr; PRK00083 762376009034 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 762376009035 hinge region; other site 762376009036 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 762376009037 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 762376009038 catalytic residue [active] 762376009039 putative FPP diphosphate binding site; other site 762376009040 putative FPP binding hydrophobic cleft; other site 762376009041 dimer interface [polypeptide binding]; other site 762376009042 putative IPP diphosphate binding site; other site 762376009043 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 762376009044 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 762376009045 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 762376009046 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 762376009047 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 762376009048 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 762376009049 zinc metallopeptidase RseP; Provisional; Region: PRK10779 762376009050 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 762376009051 active site 762376009052 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 762376009053 protein binding site [polypeptide binding]; other site 762376009054 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 762376009055 putative substrate binding region [chemical binding]; other site 762376009056 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 762376009057 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762376009058 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762376009059 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762376009060 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762376009061 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 762376009062 Surface antigen; Region: Bac_surface_Ag; pfam01103 762376009063 periplasmic chaperone; Provisional; Region: PRK10780 762376009064 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 762376009065 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 762376009066 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 762376009067 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 762376009068 trimer interface [polypeptide binding]; other site 762376009069 active site 762376009070 UDP-GlcNAc binding site [chemical binding]; other site 762376009071 lipid binding site [chemical binding]; lipid-binding site 762376009072 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 762376009073 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 762376009074 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 762376009075 active site 762376009076 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 762376009077 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 762376009078 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 762376009079 RNA/DNA hybrid binding site [nucleotide binding]; other site 762376009080 active site 762376009081 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 762376009082 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762376009083 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 762376009084 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 762376009085 PEP synthetase regulatory protein; Provisional; Region: PRK05339 762376009086 phosphoenolpyruvate synthase; Validated; Region: PRK06464 762376009087 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 762376009088 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 762376009089 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 762376009090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376009091 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376009092 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 762376009093 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762376009094 DNA binding site [nucleotide binding] 762376009095 active site 762376009096 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 762376009097 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 762376009098 catalytic triad [active] 762376009099 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 762376009100 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 762376009101 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376009102 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376009103 metal binding site [ion binding]; metal-binding site 762376009104 active site 762376009105 I-site; other site 762376009106 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 762376009107 SmpB-tmRNA interface; other site 762376009108 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 762376009109 putative coenzyme Q binding site [chemical binding]; other site 762376009110 hypothetical protein; Validated; Region: PRK01777 762376009111 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376009112 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376009113 active site 762376009114 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 762376009115 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376009116 substrate binding site [chemical binding]; other site 762376009117 oxyanion hole (OAH) forming residues; other site 762376009118 trimer interface [polypeptide binding]; other site 762376009119 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 762376009120 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762376009121 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 762376009122 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376009123 CoenzymeA binding site [chemical binding]; other site 762376009124 subunit interaction site [polypeptide binding]; other site 762376009125 PHB binding site; other site 762376009126 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 762376009127 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 762376009128 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 762376009129 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 762376009130 YceG-like family; Region: YceG; pfam02618 762376009131 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 762376009132 dimerization interface [polypeptide binding]; other site 762376009133 thymidylate kinase; Validated; Region: tmk; PRK00698 762376009134 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 762376009135 TMP-binding site; other site 762376009136 ATP-binding site [chemical binding]; other site 762376009137 DNA polymerase III subunit delta'; Validated; Region: PRK06964 762376009138 DNA polymerase III subunit delta'; Validated; Region: PRK08485 762376009139 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 762376009140 active site 762376009141 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 762376009142 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 762376009143 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 762376009144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376009145 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376009146 DNA-binding site [nucleotide binding]; DNA binding site 762376009147 FCD domain; Region: FCD; pfam07729 762376009148 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 762376009149 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376009150 inhibitor-cofactor binding pocket; inhibition site 762376009151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376009152 catalytic residue [active] 762376009153 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 762376009154 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376009155 enoyl-CoA hydratase; Provisional; Region: PRK06127 762376009156 substrate binding site [chemical binding]; other site 762376009157 oxyanion hole (OAH) forming residues; other site 762376009158 trimer interface [polypeptide binding]; other site 762376009159 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376009160 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376009161 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376009162 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 762376009163 ligand binding site [chemical binding]; other site 762376009164 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376009165 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376009166 TM-ABC transporter signature motif; other site 762376009167 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376009168 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376009169 TM-ABC transporter signature motif; other site 762376009170 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376009171 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376009172 Walker A/P-loop; other site 762376009173 ATP binding site [chemical binding]; other site 762376009174 Q-loop/lid; other site 762376009175 ABC transporter signature motif; other site 762376009176 Walker B; other site 762376009177 D-loop; other site 762376009178 H-loop/switch region; other site 762376009179 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376009180 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376009181 Walker A/P-loop; other site 762376009182 ATP binding site [chemical binding]; other site 762376009183 Q-loop/lid; other site 762376009184 ABC transporter signature motif; other site 762376009185 Walker B; other site 762376009186 D-loop; other site 762376009187 H-loop/switch region; other site 762376009188 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376009189 Amidase; Region: Amidase; cl11426 762376009190 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376009191 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376009192 putative DNA binding site [nucleotide binding]; other site 762376009193 putative Zn2+ binding site [ion binding]; other site 762376009194 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376009195 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376009196 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376009197 substrate binding pocket [chemical binding]; other site 762376009198 membrane-bound complex binding site; other site 762376009199 hinge residues; other site 762376009200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376009201 dimer interface [polypeptide binding]; other site 762376009202 conserved gate region; other site 762376009203 putative PBP binding loops; other site 762376009204 ABC-ATPase subunit interface; other site 762376009205 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376009206 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376009207 Walker A/P-loop; other site 762376009208 ATP binding site [chemical binding]; other site 762376009209 Q-loop/lid; other site 762376009210 ABC transporter signature motif; other site 762376009211 Walker B; other site 762376009212 D-loop; other site 762376009213 H-loop/switch region; other site 762376009214 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 762376009215 putative active site [active] 762376009216 putative metal binding site [ion binding]; other site 762376009217 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 762376009218 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 762376009219 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 762376009220 NAD(P) binding site [chemical binding]; other site 762376009221 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 762376009222 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 762376009223 trimer interface [polypeptide binding]; other site 762376009224 eyelet of channel; other site 762376009225 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 762376009226 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 762376009227 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 762376009228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762376009229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376009230 Coenzyme A binding pocket [chemical binding]; other site 762376009231 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 762376009232 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 762376009233 C-terminal domain interface [polypeptide binding]; other site 762376009234 GSH binding site (G-site) [chemical binding]; other site 762376009235 dimer interface [polypeptide binding]; other site 762376009236 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 762376009237 N-terminal domain interface [polypeptide binding]; other site 762376009238 putative dimer interface [polypeptide binding]; other site 762376009239 active site 762376009240 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376009241 EamA-like transporter family; Region: EamA; pfam00892 762376009242 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 762376009243 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 762376009244 putative DNA binding site [nucleotide binding]; other site 762376009245 putative Zn2+ binding site [ion binding]; other site 762376009246 AsnC family; Region: AsnC_trans_reg; pfam01037 762376009247 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 762376009248 catalytic residues [active] 762376009249 dimer interface [polypeptide binding]; other site 762376009250 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376009251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376009252 putative substrate translocation pore; other site 762376009253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762376009254 TPR motif; other site 762376009255 TPR repeat; Region: TPR_11; pfam13414 762376009256 binding surface 762376009257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376009258 PAS domain; Region: PAS_9; pfam13426 762376009259 putative active site [active] 762376009260 heme pocket [chemical binding]; other site 762376009261 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 762376009262 DNA photolyase; Region: DNA_photolyase; pfam00875 762376009263 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376009264 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376009265 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 762376009266 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 762376009267 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 762376009268 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 762376009269 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 762376009270 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 762376009271 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 762376009272 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 762376009273 catalytic triad [active] 762376009274 Predicted membrane protein [Function unknown]; Region: COG2259 762376009275 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 762376009276 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 762376009277 ATP binding site [chemical binding]; other site 762376009278 Mg++ binding site [ion binding]; other site 762376009279 motif III; other site 762376009280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376009281 nucleotide binding region [chemical binding]; other site 762376009282 ATP-binding site [chemical binding]; other site 762376009283 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 762376009284 putative RNA binding site [nucleotide binding]; other site 762376009285 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376009286 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 762376009287 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376009288 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 762376009289 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376009290 PYR/PP interface [polypeptide binding]; other site 762376009291 dimer interface [polypeptide binding]; other site 762376009292 TPP binding site [chemical binding]; other site 762376009293 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376009294 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 762376009295 TPP-binding site; other site 762376009296 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 762376009297 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376009298 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 762376009299 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376009300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376009301 dimer interface [polypeptide binding]; other site 762376009302 conserved gate region; other site 762376009303 putative PBP binding loops; other site 762376009304 ABC-ATPase subunit interface; other site 762376009305 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 762376009306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376009307 dimer interface [polypeptide binding]; other site 762376009308 conserved gate region; other site 762376009309 putative PBP binding loops; other site 762376009310 ABC-ATPase subunit interface; other site 762376009311 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376009312 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376009313 Walker A/P-loop; other site 762376009314 ATP binding site [chemical binding]; other site 762376009315 Q-loop/lid; other site 762376009316 ABC transporter signature motif; other site 762376009317 Walker B; other site 762376009318 D-loop; other site 762376009319 H-loop/switch region; other site 762376009320 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376009321 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376009322 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376009323 Walker A/P-loop; other site 762376009324 ATP binding site [chemical binding]; other site 762376009325 Q-loop/lid; other site 762376009326 ABC transporter signature motif; other site 762376009327 Walker B; other site 762376009328 D-loop; other site 762376009329 H-loop/switch region; other site 762376009330 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376009331 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 762376009332 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 762376009333 active site 762376009334 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 762376009335 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 762376009336 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 762376009337 classical (c) SDRs; Region: SDR_c; cd05233 762376009338 NAD(P) binding site [chemical binding]; other site 762376009339 active site 762376009340 SnoaL-like domain; Region: SnoaL_2; pfam12680 762376009341 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 762376009342 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376009343 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376009344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376009345 DNA-binding site [nucleotide binding]; DNA binding site 762376009346 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376009347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376009348 homodimer interface [polypeptide binding]; other site 762376009349 catalytic residue [active] 762376009350 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376009351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376009352 dimer interface [polypeptide binding]; other site 762376009353 conserved gate region; other site 762376009354 putative PBP binding loops; other site 762376009355 ABC-ATPase subunit interface; other site 762376009356 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 762376009357 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762376009358 Walker A/P-loop; other site 762376009359 ATP binding site [chemical binding]; other site 762376009360 Q-loop/lid; other site 762376009361 ABC transporter signature motif; other site 762376009362 Walker B; other site 762376009363 D-loop; other site 762376009364 H-loop/switch region; other site 762376009365 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 762376009366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376009367 substrate binding pocket [chemical binding]; other site 762376009368 membrane-bound complex binding site; other site 762376009369 hinge residues; other site 762376009370 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 762376009371 homodecamer interface [polypeptide binding]; other site 762376009372 GTP cyclohydrolase I; Provisional; Region: PLN03044 762376009373 active site 762376009374 putative catalytic site residues [active] 762376009375 zinc binding site [ion binding]; other site 762376009376 GTP-CH-I/GFRP interaction surface; other site 762376009377 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376009378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376009379 active site 762376009380 phosphorylation site [posttranslational modification] 762376009381 intermolecular recognition site; other site 762376009382 dimerization interface [polypeptide binding]; other site 762376009383 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376009384 DNA binding residues [nucleotide binding] 762376009385 dimerization interface [polypeptide binding]; other site 762376009386 Cache domain; Region: Cache_2; pfam08269 762376009387 Histidine kinase; Region: HisKA_3; pfam07730 762376009388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376009389 ATP binding site [chemical binding]; other site 762376009390 Mg2+ binding site [ion binding]; other site 762376009391 G-X-G motif; other site 762376009392 carbon starvation protein A; Provisional; Region: PRK15015 762376009393 Carbon starvation protein CstA; Region: CstA; pfam02554 762376009394 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 762376009395 Protein of unknown function (DUF466); Region: DUF466; pfam04328 762376009396 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 762376009397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376009398 putative substrate translocation pore; other site 762376009399 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 762376009400 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 762376009401 dimerization interface [polypeptide binding]; other site 762376009402 DPS ferroxidase diiron center [ion binding]; other site 762376009403 ion pore; other site 762376009404 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376009405 methionine sulfoxide reductase A; Provisional; Region: PRK13014 762376009406 methionine sulfoxide reductase B; Provisional; Region: PRK00222 762376009407 SelR domain; Region: SelR; pfam01641 762376009408 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 762376009409 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 762376009410 Moco binding site; other site 762376009411 metal coordination site [ion binding]; other site 762376009412 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 762376009413 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 762376009414 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376009415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376009416 active site 762376009417 phosphorylation site [posttranslational modification] 762376009418 intermolecular recognition site; other site 762376009419 dimerization interface [polypeptide binding]; other site 762376009420 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376009421 DNA binding site [nucleotide binding] 762376009422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376009423 dimer interface [polypeptide binding]; other site 762376009424 phosphorylation site [posttranslational modification] 762376009425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376009426 ATP binding site [chemical binding]; other site 762376009427 Mg2+ binding site [ion binding]; other site 762376009428 G-X-G motif; other site 762376009429 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 762376009430 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 762376009431 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376009432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376009433 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 762376009434 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 762376009435 FMN binding site [chemical binding]; other site 762376009436 substrate binding site [chemical binding]; other site 762376009437 putative catalytic residue [active] 762376009438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762376009439 FeS/SAM binding site; other site 762376009440 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 762376009441 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 762376009442 ATP cone domain; Region: ATP-cone; pfam03477 762376009443 Class III ribonucleotide reductase; Region: RNR_III; cd01675 762376009444 effector binding site; other site 762376009445 active site 762376009446 Zn binding site [ion binding]; other site 762376009447 glycine loop; other site 762376009448 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 762376009449 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 762376009450 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376009451 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 762376009452 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 762376009453 dinuclear metal binding motif [ion binding]; other site 762376009454 hydroperoxidase II; Provisional; Region: katE; PRK11249 762376009455 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 762376009456 heme binding pocket [chemical binding]; other site 762376009457 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 762376009458 domain interactions; other site 762376009459 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 762376009460 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376009461 hypothetical protein; Provisional; Region: PRK07079 762376009462 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 762376009463 metal binding site [ion binding]; metal-binding site 762376009464 putative dimer interface [polypeptide binding]; other site 762376009465 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 762376009466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376009467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009468 dimerization interface [polypeptide binding]; other site 762376009469 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376009470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376009471 hypothetical protein; Provisional; Region: PRK07236 762376009472 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 762376009473 active site 762376009474 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 762376009475 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376009476 acyl-activating enzyme (AAE) consensus motif; other site 762376009477 AMP binding site [chemical binding]; other site 762376009478 active site 762376009479 CoA binding site [chemical binding]; other site 762376009480 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 762376009481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376009482 Zn binding site [ion binding]; other site 762376009483 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 762376009484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 762376009485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376009486 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376009487 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376009488 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376009489 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 762376009490 active site 762376009491 catalytic residues [active] 762376009492 metal binding site [ion binding]; metal-binding site 762376009493 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376009494 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376009495 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376009496 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 762376009497 Protein export membrane protein; Region: SecD_SecF; cl14618 762376009498 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 762376009499 Protein export membrane protein; Region: SecD_SecF; cl14618 762376009500 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376009501 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376009502 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 762376009503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376009504 RNA polymerase sigma factor; Reviewed; Region: PRK12527 762376009505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376009506 DNA binding residues [nucleotide binding] 762376009507 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376009508 FecR protein; Region: FecR; pfam04773 762376009509 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376009510 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376009511 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376009512 N-terminal plug; other site 762376009513 ligand-binding site [chemical binding]; other site 762376009514 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376009515 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 762376009516 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 762376009517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376009518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376009519 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376009520 dimerization interface [polypeptide binding]; other site 762376009521 putative effector binding pocket; other site 762376009522 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 762376009523 hypothetical protein; Provisional; Region: PRK07236 762376009524 Low affinity iron permease; Region: Iron_permease; pfam04120 762376009525 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 762376009526 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762376009527 NnrS protein; Region: NnrS; pfam05940 762376009528 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 762376009529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376009530 putative substrate translocation pore; other site 762376009531 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 762376009532 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 762376009533 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 762376009534 [4Fe-4S] binding site [ion binding]; other site 762376009535 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762376009536 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762376009537 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 762376009538 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 762376009539 molybdopterin cofactor binding site; other site 762376009540 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 762376009541 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 762376009542 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 762376009543 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 762376009544 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 762376009545 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 762376009546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762376009547 FeS/SAM binding site; other site 762376009548 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 762376009549 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 762376009550 active site clefts [active] 762376009551 zinc binding site [ion binding]; other site 762376009552 dimer interface [polypeptide binding]; other site 762376009553 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 762376009554 Walker A motif; other site 762376009555 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 762376009556 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 762376009557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376009558 dimerization interface [polypeptide binding]; other site 762376009559 GAF domain; Region: GAF; pfam01590 762376009560 Histidine kinase; Region: HisKA_3; pfam07730 762376009561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376009562 ATP binding site [chemical binding]; other site 762376009563 Mg2+ binding site [ion binding]; other site 762376009564 G-X-G motif; other site 762376009565 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376009566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376009567 active site 762376009568 phosphorylation site [posttranslational modification] 762376009569 intermolecular recognition site; other site 762376009570 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376009571 DNA binding residues [nucleotide binding] 762376009572 dimerization interface [polypeptide binding]; other site 762376009573 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376009574 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 762376009575 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376009576 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 762376009577 TPP-binding site [chemical binding]; other site 762376009578 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376009579 PYR/PP interface [polypeptide binding]; other site 762376009580 dimer interface [polypeptide binding]; other site 762376009581 TPP binding site [chemical binding]; other site 762376009582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376009583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009584 dimerization interface [polypeptide binding]; other site 762376009585 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 762376009586 Peptidase family U32; Region: Peptidase_U32; pfam01136 762376009587 putative protease; Provisional; Region: PRK15447 762376009588 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 762376009589 SCP-2 sterol transfer family; Region: SCP2; cl01225 762376009590 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 762376009591 classical (c) SDRs; Region: SDR_c; cd05233 762376009592 NAD(P) binding site [chemical binding]; other site 762376009593 active site 762376009594 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 762376009595 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762376009596 homodimer interface [polypeptide binding]; other site 762376009597 substrate-cofactor binding pocket; other site 762376009598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376009599 catalytic residue [active] 762376009600 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376009601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376009602 DNA-binding site [nucleotide binding]; DNA binding site 762376009603 FCD domain; Region: FCD; pfam07729 762376009604 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 762376009605 hypothetical protein; Validated; Region: PRK08245 762376009606 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376009607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376009608 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376009609 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762376009610 inhibitor site; inhibition site 762376009611 active site 762376009612 dimer interface [polypeptide binding]; other site 762376009613 catalytic residue [active] 762376009614 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376009615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376009616 DNA-binding site [nucleotide binding]; DNA binding site 762376009617 FCD domain; Region: FCD; pfam07729 762376009618 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 762376009619 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 762376009620 FMN-binding pocket [chemical binding]; other site 762376009621 flavin binding motif; other site 762376009622 phosphate binding motif [ion binding]; other site 762376009623 beta-alpha-beta structure motif; other site 762376009624 NAD binding pocket [chemical binding]; other site 762376009625 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376009626 catalytic loop [active] 762376009627 iron binding site [ion binding]; other site 762376009628 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376009629 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 762376009630 iron-sulfur cluster [ion binding]; other site 762376009631 [2Fe-2S] cluster binding site [ion binding]; other site 762376009632 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 762376009633 alpha subunit interface [polypeptide binding]; other site 762376009634 active site 762376009635 substrate binding site [chemical binding]; other site 762376009636 Fe binding site [ion binding]; other site 762376009637 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376009638 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376009639 putative ligand binding site [chemical binding]; other site 762376009640 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376009641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376009642 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 762376009643 substrate binding pocket [chemical binding]; other site 762376009644 dimerization interface [polypeptide binding]; other site 762376009645 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 762376009646 PAAR motif; Region: PAAR_motif; pfam05488 762376009647 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376009648 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376009649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376009650 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376009651 dimerization interface [polypeptide binding]; other site 762376009652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376009653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376009654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376009655 dimerization interface [polypeptide binding]; other site 762376009656 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376009657 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376009658 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376009659 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376009660 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376009661 active site 762376009662 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376009663 classical (c) SDRs; Region: SDR_c; cd05233 762376009664 NAD(P) binding site [chemical binding]; other site 762376009665 active site 762376009666 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 762376009667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376009668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376009669 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 762376009670 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 762376009671 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 762376009672 NmrA-like family; Region: NmrA; pfam05368 762376009673 NADP binding site [chemical binding]; other site 762376009674 active site 762376009675 regulatory binding site [polypeptide binding]; other site 762376009676 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376009677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376009678 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376009679 putative effector binding pocket; other site 762376009680 dimerization interface [polypeptide binding]; other site 762376009681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 762376009682 Coenzyme A binding pocket [chemical binding]; other site 762376009683 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 762376009684 dimer interface [polypeptide binding]; other site 762376009685 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376009686 metal binding site [ion binding]; metal-binding site 762376009687 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 762376009688 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 762376009689 putative ADP-ribose binding site [chemical binding]; other site 762376009690 putative active site [active] 762376009691 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 762376009692 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 762376009693 Autotransporter beta-domain; Region: Autotransporter; smart00869 762376009694 short chain dehydrogenase; Provisional; Region: PRK12746 762376009695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376009696 NAD(P) binding site [chemical binding]; other site 762376009697 active site 762376009698 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 762376009699 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376009700 acyl-activating enzyme (AAE) consensus motif; other site 762376009701 AMP binding site [chemical binding]; other site 762376009702 active site 762376009703 CoA binding site [chemical binding]; other site 762376009704 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376009705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376009706 dimer interface [polypeptide binding]; other site 762376009707 conserved gate region; other site 762376009708 putative PBP binding loops; other site 762376009709 ABC-ATPase subunit interface; other site 762376009710 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376009711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376009712 dimer interface [polypeptide binding]; other site 762376009713 conserved gate region; other site 762376009714 putative PBP binding loops; other site 762376009715 ABC-ATPase subunit interface; other site 762376009716 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376009717 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 762376009718 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376009719 CoenzymeA binding site [chemical binding]; other site 762376009720 subunit interaction site [polypeptide binding]; other site 762376009721 PHB binding site; other site 762376009722 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 762376009723 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762376009724 NAD(P) binding site [chemical binding]; other site 762376009725 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 762376009726 putative active site [active] 762376009727 Zn binding site [ion binding]; other site 762376009728 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 762376009729 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376009730 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376009731 substrate binding pocket [chemical binding]; other site 762376009732 membrane-bound complex binding site; other site 762376009733 hinge residues; other site 762376009734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376009735 dimer interface [polypeptide binding]; other site 762376009736 conserved gate region; other site 762376009737 putative PBP binding loops; other site 762376009738 ABC-ATPase subunit interface; other site 762376009739 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376009740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376009741 dimer interface [polypeptide binding]; other site 762376009742 conserved gate region; other site 762376009743 putative PBP binding loops; other site 762376009744 ABC-ATPase subunit interface; other site 762376009745 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376009746 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376009747 Walker A/P-loop; other site 762376009748 ATP binding site [chemical binding]; other site 762376009749 Q-loop/lid; other site 762376009750 ABC transporter signature motif; other site 762376009751 Walker B; other site 762376009752 D-loop; other site 762376009753 H-loop/switch region; other site 762376009754 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 762376009755 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376009756 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376009757 catalytic residue [active] 762376009758 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 762376009759 active site 762376009760 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 762376009761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376009762 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 762376009763 substrate binding site [chemical binding]; other site 762376009764 dimerization interface [polypeptide binding]; other site 762376009765 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 762376009766 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376009767 active site residue [active] 762376009768 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376009769 active site residue [active] 762376009770 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376009771 active site residue [active] 762376009772 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376009773 active site residue [active] 762376009774 Domain of unknown function (DUF336); Region: DUF336; cl01249 762376009775 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 762376009776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376009777 active site 762376009778 phosphorylation site [posttranslational modification] 762376009779 intermolecular recognition site; other site 762376009780 dimerization interface [polypeptide binding]; other site 762376009781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376009782 DNA binding residues [nucleotide binding] 762376009783 dimerization interface [polypeptide binding]; other site 762376009784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376009785 dimer interface [polypeptide binding]; other site 762376009786 phosphorylation site [posttranslational modification] 762376009787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376009788 ATP binding site [chemical binding]; other site 762376009789 Mg2+ binding site [ion binding]; other site 762376009790 G-X-G motif; other site 762376009791 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 762376009792 HPP family; Region: HPP; pfam04982 762376009793 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 762376009794 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376009795 MarR family; Region: MarR_2; pfam12802 762376009796 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 762376009797 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 762376009798 Cl- selectivity filter; other site 762376009799 Cl- binding residues [ion binding]; other site 762376009800 pore gating glutamate residue; other site 762376009801 dimer interface [polypeptide binding]; other site 762376009802 FOG: CBS domain [General function prediction only]; Region: COG0517 762376009803 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 762376009804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376009805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376009806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376009807 dimerization interface [polypeptide binding]; other site 762376009808 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 762376009809 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 762376009810 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376009811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376009812 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 762376009813 substrate binding pocket [chemical binding]; other site 762376009814 dimerization interface [polypeptide binding]; other site 762376009815 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 762376009816 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376009817 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 762376009818 acyl-activating enzyme (AAE) consensus motif; other site 762376009819 putative AMP binding site [chemical binding]; other site 762376009820 putative active site [active] 762376009821 putative CoA binding site [chemical binding]; other site 762376009822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376009823 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376009824 putative substrate translocation pore; other site 762376009825 lipid-transfer protein; Provisional; Region: PRK07855 762376009826 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376009827 active site 762376009828 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376009829 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 762376009830 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 762376009831 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762376009832 catalytic residues [active] 762376009833 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376009834 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376009835 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376009836 hypothetical protein; Validated; Region: PRK07586 762376009837 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376009838 PYR/PP interface [polypeptide binding]; other site 762376009839 dimer interface [polypeptide binding]; other site 762376009840 TPP binding site [chemical binding]; other site 762376009841 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 762376009842 TPP-binding site [chemical binding]; other site 762376009843 dimer interface [polypeptide binding]; other site 762376009844 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376009845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376009846 NAD(P) binding site [chemical binding]; other site 762376009847 active site 762376009848 Ycf48-like protein; Provisional; Region: PRK13684 762376009849 VPS10 domain; Region: VPS10; smart00602 762376009850 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 762376009851 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376009852 putative active site [active] 762376009853 putative metal binding site [ion binding]; other site 762376009854 Amino acid synthesis; Region: AA_synth; pfam06684 762376009855 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762376009856 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 762376009857 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 762376009858 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 762376009859 hypothetical protein; Provisional; Region: PRK07236 762376009860 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 762376009861 Sulfatase; Region: Sulfatase; cl17466 762376009862 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376009863 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376009864 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376009865 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376009866 substrate binding pocket [chemical binding]; other site 762376009867 membrane-bound complex binding site; other site 762376009868 hinge residues; other site 762376009869 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376009870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376009871 dimer interface [polypeptide binding]; other site 762376009872 conserved gate region; other site 762376009873 putative PBP binding loops; other site 762376009874 ABC-ATPase subunit interface; other site 762376009875 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376009876 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376009877 Walker A/P-loop; other site 762376009878 ATP binding site [chemical binding]; other site 762376009879 Q-loop/lid; other site 762376009880 ABC transporter signature motif; other site 762376009881 Walker B; other site 762376009882 D-loop; other site 762376009883 H-loop/switch region; other site 762376009884 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 762376009885 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762376009886 Walker A/P-loop; other site 762376009887 ATP binding site [chemical binding]; other site 762376009888 Q-loop/lid; other site 762376009889 ABC transporter signature motif; other site 762376009890 Walker B; other site 762376009891 D-loop; other site 762376009892 H-loop/switch region; other site 762376009893 FecCD transport family; Region: FecCD; pfam01032 762376009894 ABC-ATPase subunit interface; other site 762376009895 dimer interface [polypeptide binding]; other site 762376009896 putative PBP binding regions; other site 762376009897 FecCD transport family; Region: FecCD; pfam01032 762376009898 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 762376009899 dimer interface [polypeptide binding]; other site 762376009900 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 762376009901 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 762376009902 intersubunit interface [polypeptide binding]; other site 762376009903 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376009904 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376009905 N-terminal plug; other site 762376009906 ligand-binding site [chemical binding]; other site 762376009907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376009908 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376009909 putative substrate translocation pore; other site 762376009910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376009911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376009912 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376009913 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 762376009914 iron-sulfur cluster [ion binding]; other site 762376009915 [2Fe-2S] cluster binding site [ion binding]; other site 762376009916 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 762376009917 alpha subunit interface [polypeptide binding]; other site 762376009918 active site 762376009919 substrate binding site [chemical binding]; other site 762376009920 Fe binding site [ion binding]; other site 762376009921 siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950 762376009922 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 762376009923 IucA / IucC family; Region: IucA_IucC; pfam04183 762376009924 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 762376009925 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 762376009926 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 762376009927 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 762376009928 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376009929 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376009930 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376009931 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376009932 dimerization interface [polypeptide binding]; other site 762376009933 substrate binding pocket [chemical binding]; other site 762376009934 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 762376009935 multidrug efflux protein; Reviewed; Region: PRK09579 762376009936 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376009937 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376009938 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376009939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 762376009940 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 762376009941 Walker A/P-loop; other site 762376009942 ATP binding site [chemical binding]; other site 762376009943 Q-loop/lid; other site 762376009944 ABC transporter signature motif; other site 762376009945 Walker B; other site 762376009946 D-loop; other site 762376009947 H-loop/switch region; other site 762376009948 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 762376009949 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 762376009950 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 762376009951 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 762376009952 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 762376009953 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762376009954 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 762376009955 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 762376009956 threonine dehydratase; Reviewed; Region: PRK09224 762376009957 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 762376009958 tetramer interface [polypeptide binding]; other site 762376009959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376009960 catalytic residue [active] 762376009961 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 762376009962 putative Ile/Val binding site [chemical binding]; other site 762376009963 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 762376009964 putative Ile/Val binding site [chemical binding]; other site 762376009965 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 762376009966 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376009967 putative active site [active] 762376009968 catalytic residue [active] 762376009969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376009970 Fic family protein [Function unknown]; Region: COG3177 762376009971 Fic/DOC family; Region: Fic; pfam02661 762376009972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376009973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376009974 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376009975 putative dimerization interface [polypeptide binding]; other site 762376009976 thiamine pyrophosphate protein; Validated; Region: PRK08199 762376009977 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376009978 PYR/PP interface [polypeptide binding]; other site 762376009979 dimer interface [polypeptide binding]; other site 762376009980 TPP binding site [chemical binding]; other site 762376009981 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376009982 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 762376009983 TPP-binding site [chemical binding]; other site 762376009984 aldolase II superfamily protein; Provisional; Region: PRK07044 762376009985 intersubunit interface [polypeptide binding]; other site 762376009986 active site 762376009987 Zn2+ binding site [ion binding]; other site 762376009988 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376009989 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 762376009990 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 762376009991 NAD(P) binding site [chemical binding]; other site 762376009992 catalytic residues [active] 762376009993 allantoate amidohydrolase; Reviewed; Region: PRK12893 762376009994 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762376009995 active site 762376009996 metal binding site [ion binding]; metal-binding site 762376009997 dimer interface [polypeptide binding]; other site 762376009998 thiamine pyrophosphate protein; Validated; Region: PRK08199 762376009999 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376010000 PYR/PP interface [polypeptide binding]; other site 762376010001 dimer interface [polypeptide binding]; other site 762376010002 TPP binding site [chemical binding]; other site 762376010003 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376010004 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 762376010005 TPP-binding site [chemical binding]; other site 762376010006 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 762376010007 DctM-like transporters; Region: DctM; pfam06808 762376010008 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 762376010009 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 762376010010 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 762376010011 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 762376010012 Uncharacterized conserved protein [Function unknown]; Region: COG3391 762376010013 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 762376010014 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376010015 Walker A/P-loop; other site 762376010016 ATP binding site [chemical binding]; other site 762376010017 Q-loop/lid; other site 762376010018 ABC transporter signature motif; other site 762376010019 Walker B; other site 762376010020 D-loop; other site 762376010021 H-loop/switch region; other site 762376010022 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376010023 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376010024 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376010025 Walker A/P-loop; other site 762376010026 ATP binding site [chemical binding]; other site 762376010027 Q-loop/lid; other site 762376010028 ABC transporter signature motif; other site 762376010029 Walker B; other site 762376010030 D-loop; other site 762376010031 H-loop/switch region; other site 762376010032 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376010033 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376010034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376010035 dimer interface [polypeptide binding]; other site 762376010036 conserved gate region; other site 762376010037 putative PBP binding loops; other site 762376010038 ABC-ATPase subunit interface; other site 762376010039 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376010040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376010041 dimer interface [polypeptide binding]; other site 762376010042 conserved gate region; other site 762376010043 putative PBP binding loops; other site 762376010044 ABC-ATPase subunit interface; other site 762376010045 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 762376010046 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376010047 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376010048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376010049 DNA-binding site [nucleotide binding]; DNA binding site 762376010050 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376010051 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 762376010052 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 762376010053 active site 762376010054 Zn binding site [ion binding]; other site 762376010055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376010056 active site 762376010057 phosphorylation site [posttranslational modification] 762376010058 intermolecular recognition site; other site 762376010059 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376010060 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376010061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376010062 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376010063 putative dimerization interface [polypeptide binding]; other site 762376010064 Cupin domain; Region: Cupin_2; cl17218 762376010065 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376010066 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 762376010067 active site 762376010068 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 762376010069 Enoylreductase; Region: PKS_ER; smart00829 762376010070 NAD(P) binding site [chemical binding]; other site 762376010071 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376010072 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 762376010073 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 762376010074 trimer interface [polypeptide binding]; other site 762376010075 eyelet of channel; other site 762376010076 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 762376010077 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 762376010078 putative active site [active] 762376010079 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 762376010080 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 762376010081 active site 762376010082 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 762376010083 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376010084 Sulfatase; Region: Sulfatase; pfam00884 762376010085 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 762376010086 Uncharacterized conserved protein [Function unknown]; Region: COG1262 762376010087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376010088 DNA-binding site [nucleotide binding]; DNA binding site 762376010089 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376010090 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 762376010091 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 762376010092 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376010093 FAD binding domain; Region: FAD_binding_3; pfam01494 762376010094 hypothetical protein; Provisional; Region: PRK07236 762376010095 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762376010096 active site 762376010097 metal binding site [ion binding]; metal-binding site 762376010098 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 762376010099 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376010100 putative active site [active] 762376010101 putative metal binding site [ion binding]; other site 762376010102 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376010103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376010104 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 762376010105 putative effector binding pocket; other site 762376010106 putative dimerization interface [polypeptide binding]; other site 762376010107 Isochorismatase family; Region: Isochorismatase; pfam00857 762376010108 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 762376010109 catalytic triad [active] 762376010110 dimer interface [polypeptide binding]; other site 762376010111 conserved cis-peptide bond; other site 762376010112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376010113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376010114 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376010115 dimerization interface [polypeptide binding]; other site 762376010116 substrate binding pocket [chemical binding]; other site 762376010117 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 762376010118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376010119 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376010120 putative substrate translocation pore; other site 762376010121 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762376010122 classical (c) SDRs; Region: SDR_c; cd05233 762376010123 NAD(P) binding site [chemical binding]; other site 762376010124 active site 762376010125 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376010126 classical (c) SDRs; Region: SDR_c; cd05233 762376010127 NAD(P) binding site [chemical binding]; other site 762376010128 active site 762376010129 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376010130 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376010131 Walker A/P-loop; other site 762376010132 ATP binding site [chemical binding]; other site 762376010133 Q-loop/lid; other site 762376010134 ABC transporter signature motif; other site 762376010135 Walker B; other site 762376010136 D-loop; other site 762376010137 H-loop/switch region; other site 762376010138 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376010139 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376010140 Walker A/P-loop; other site 762376010141 ATP binding site [chemical binding]; other site 762376010142 Q-loop/lid; other site 762376010143 ABC transporter signature motif; other site 762376010144 Walker B; other site 762376010145 D-loop; other site 762376010146 H-loop/switch region; other site 762376010147 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376010148 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376010149 TM-ABC transporter signature motif; other site 762376010150 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376010151 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376010152 TM-ABC transporter signature motif; other site 762376010153 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376010154 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 762376010155 putative ligand binding site [chemical binding]; other site 762376010156 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 762376010157 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 762376010158 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 762376010159 active site 762376010160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376010161 S-adenosylmethionine binding site [chemical binding]; other site 762376010162 sulfite oxidase; Provisional; Region: PLN00177 762376010163 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 762376010164 Moco binding site; other site 762376010165 metal coordination site [ion binding]; other site 762376010166 dimerization interface [polypeptide binding]; other site 762376010167 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 762376010168 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376010169 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376010170 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376010171 N-terminal plug; other site 762376010172 ligand-binding site [chemical binding]; other site 762376010173 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376010174 FecR protein; Region: FecR; pfam04773 762376010175 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 762376010176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376010177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376010178 DNA binding residues [nucleotide binding] 762376010179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376010180 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 762376010181 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376010182 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376010183 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 762376010184 Protein export membrane protein; Region: SecD_SecF; cl14618 762376010185 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 762376010186 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 762376010187 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762376010188 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 762376010189 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 762376010190 dimerization domain [polypeptide binding]; other site 762376010191 dimer interface [polypeptide binding]; other site 762376010192 catalytic residues [active] 762376010193 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 762376010194 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 762376010195 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762376010196 catalytic residues [active] 762376010197 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 762376010198 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 762376010199 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 762376010200 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 762376010201 DsbD alpha interface [polypeptide binding]; other site 762376010202 catalytic residues [active] 762376010203 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 762376010204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376010205 active site 762376010206 phosphorylation site [posttranslational modification] 762376010207 intermolecular recognition site; other site 762376010208 dimerization interface [polypeptide binding]; other site 762376010209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376010210 DNA binding site [nucleotide binding] 762376010211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376010212 dimer interface [polypeptide binding]; other site 762376010213 phosphorylation site [posttranslational modification] 762376010214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376010215 ATP binding site [chemical binding]; other site 762376010216 Mg2+ binding site [ion binding]; other site 762376010217 G-X-G motif; other site 762376010218 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 762376010219 CGNR zinc finger; Region: zf-CGNR; pfam11706 762376010220 Epoxide hydrolase N terminus; Region: EHN; pfam06441 762376010221 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 762376010222 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376010223 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 762376010224 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376010225 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 762376010226 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376010227 N-terminal plug; other site 762376010228 ligand-binding site [chemical binding]; other site 762376010229 fec operon regulator FecR; Reviewed; Region: PRK09774 762376010230 FecR protein; Region: FecR; pfam04773 762376010231 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376010232 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376010233 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376010234 DNA binding residues [nucleotide binding] 762376010235 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 762376010236 Autotransporter beta-domain; Region: Autotransporter; pfam03797 762376010237 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 762376010238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376010239 putative substrate translocation pore; other site 762376010240 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376010241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376010242 DNA-binding site [nucleotide binding]; DNA binding site 762376010243 FCD domain; Region: FCD; pfam07729 762376010244 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376010245 Amidase; Region: Amidase; cl11426 762376010246 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376010247 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376010248 enoyl-CoA hydratase; Provisional; Region: PRK06127 762376010249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376010250 substrate binding site [chemical binding]; other site 762376010251 oxyanion hole (OAH) forming residues; other site 762376010252 trimer interface [polypeptide binding]; other site 762376010253 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 762376010254 putative active site [active] 762376010255 putative catalytic site [active] 762376010256 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 762376010257 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 762376010258 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376010259 N-terminal plug; other site 762376010260 ligand-binding site [chemical binding]; other site 762376010261 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 762376010262 PemK-like protein; Region: PemK; pfam02452 762376010263 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 762376010264 C-terminal domain interface [polypeptide binding]; other site 762376010265 GSH binding site (G-site) [chemical binding]; other site 762376010266 dimer interface [polypeptide binding]; other site 762376010267 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 762376010268 dimer interface [polypeptide binding]; other site 762376010269 N-terminal domain interface [polypeptide binding]; other site 762376010270 substrate binding pocket (H-site) [chemical binding]; other site 762376010271 Uncharacterized conserved protein [Function unknown]; Region: COG2353 762376010272 L-type amino acid transporter; Region: 2A0308; TIGR00911 762376010273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376010274 S-adenosylmethionine binding site [chemical binding]; other site 762376010275 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376010276 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376010277 active site 762376010278 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376010279 CoA binding domain; Region: CoA_binding_2; pfam13380 762376010280 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762376010281 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762376010282 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 762376010283 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376010284 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762376010285 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 762376010286 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376010287 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376010288 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762376010289 tetramerization interface [polypeptide binding]; other site 762376010290 NAD(P) binding site [chemical binding]; other site 762376010291 catalytic residues [active] 762376010292 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376010293 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376010294 putative ligand binding site [chemical binding]; other site 762376010295 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762376010296 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376010297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376010298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376010299 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376010300 putative dimerization interface [polypeptide binding]; other site 762376010301 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 762376010302 HipA-like N-terminal domain; Region: HipA_N; pfam07805 762376010303 HipA-like C-terminal domain; Region: HipA_C; pfam07804 762376010304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376010305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376010306 non-specific DNA binding site [nucleotide binding]; other site 762376010307 salt bridge; other site 762376010308 sequence-specific DNA binding site [nucleotide binding]; other site 762376010309 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 762376010310 dimer interface [polypeptide binding]; other site 762376010311 catalytic triad [active] 762376010312 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 762376010313 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376010314 RNA binding surface [nucleotide binding]; other site 762376010315 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 762376010316 active site 762376010317 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 762376010318 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 762376010319 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376010320 substrate binding pocket [chemical binding]; other site 762376010321 membrane-bound complex binding site; other site 762376010322 hinge residues; other site 762376010323 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 762376010324 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762376010325 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376010326 catalytic residue [active] 762376010327 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 762376010328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376010329 D-galactonate transporter; Region: 2A0114; TIGR00893 762376010330 putative substrate translocation pore; other site 762376010331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376010332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376010333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010334 dimerization interface [polypeptide binding]; other site 762376010335 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376010336 active site 762376010337 DNA binding site [nucleotide binding] 762376010338 Int/Topo IB signature motif; other site 762376010339 Cache domain; Region: Cache_1; pfam02743 762376010340 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376010341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376010342 metal binding site [ion binding]; metal-binding site 762376010343 active site 762376010344 I-site; other site 762376010345 Uncharacterized conserved protein [Function unknown]; Region: COG3791 762376010346 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 762376010347 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 762376010348 Rdx family; Region: Rdx; cl01407 762376010349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376010350 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 762376010351 putative substrate translocation pore; other site 762376010352 enoyl-CoA hydratase; Validated; Region: PRK08139 762376010353 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376010354 substrate binding site [chemical binding]; other site 762376010355 oxyanion hole (OAH) forming residues; other site 762376010356 trimer interface [polypeptide binding]; other site 762376010357 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 762376010358 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 762376010359 Chromate transporter; Region: Chromate_transp; pfam02417 762376010360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376010361 dimer interface [polypeptide binding]; other site 762376010362 phosphorylation site [posttranslational modification] 762376010363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376010364 ATP binding site [chemical binding]; other site 762376010365 Mg2+ binding site [ion binding]; other site 762376010366 G-X-G motif; other site 762376010367 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762376010368 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762376010369 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376010370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376010371 DNA-binding site [nucleotide binding]; DNA binding site 762376010372 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376010373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376010374 homodimer interface [polypeptide binding]; other site 762376010375 catalytic residue [active] 762376010376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376010377 Coenzyme A binding pocket [chemical binding]; other site 762376010378 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 762376010379 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762376010380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762376010381 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376010382 Sulfatase; Region: Sulfatase; pfam00884 762376010383 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 762376010384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376010385 motif II; other site 762376010386 Oxygen tolerance; Region: BatD; pfam13584 762376010387 von Willebrand factor type A domain; Region: VWA_2; pfam13519 762376010388 metal ion-dependent adhesion site (MIDAS); other site 762376010389 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 762376010390 metal ion-dependent adhesion site (MIDAS); other site 762376010391 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 762376010392 Protein of unknown function DUF58; Region: DUF58; pfam01882 762376010393 MoxR-like ATPases [General function prediction only]; Region: COG0714 762376010394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376010395 ATP binding site [chemical binding]; other site 762376010396 Walker A motif; other site 762376010397 Walker B motif; other site 762376010398 arginine finger; other site 762376010399 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 762376010400 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 762376010401 Uncharacterized conserved protein [Function unknown]; Region: COG1262 762376010402 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 762376010403 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 762376010404 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762376010405 Transporter associated domain; Region: CorC_HlyC; smart01091 762376010406 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 762376010407 MgtC family; Region: MgtC; pfam02308 762376010408 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376010409 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376010410 Walker A/P-loop; other site 762376010411 ATP binding site [chemical binding]; other site 762376010412 Q-loop/lid; other site 762376010413 ABC transporter signature motif; other site 762376010414 Walker B; other site 762376010415 D-loop; other site 762376010416 H-loop/switch region; other site 762376010417 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376010418 Walker A/P-loop; other site 762376010419 ATP binding site [chemical binding]; other site 762376010420 Q-loop/lid; other site 762376010421 ABC transporter signature motif; other site 762376010422 Walker B; other site 762376010423 D-loop; other site 762376010424 H-loop/switch region; other site 762376010425 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376010426 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 762376010427 putative catalytic site [active] 762376010428 putative metal binding site [ion binding]; other site 762376010429 putative phosphate binding site [ion binding]; other site 762376010430 cardiolipin synthase 2; Provisional; Region: PRK11263 762376010431 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 762376010432 putative active site [active] 762376010433 catalytic site [active] 762376010434 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 762376010435 putative active site [active] 762376010436 catalytic site [active] 762376010437 Predicted integral membrane protein [Function unknown]; Region: COG0392 762376010438 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 762376010439 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 762376010440 thiamine pyrophosphate protein; Provisional; Region: PRK08273 762376010441 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 762376010442 PYR/PP interface [polypeptide binding]; other site 762376010443 dimer interface [polypeptide binding]; other site 762376010444 tetramer interface [polypeptide binding]; other site 762376010445 TPP binding site [chemical binding]; other site 762376010446 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376010447 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 762376010448 TPP-binding site [chemical binding]; other site 762376010449 glycogen synthase; Provisional; Region: glgA; PRK00654 762376010450 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 762376010451 ADP-binding pocket [chemical binding]; other site 762376010452 homodimer interface [polypeptide binding]; other site 762376010453 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 762376010454 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 762376010455 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 762376010456 active site 762376010457 homodimer interface [polypeptide binding]; other site 762376010458 catalytic site [active] 762376010459 acceptor binding site [chemical binding]; other site 762376010460 trehalose synthase; Region: treS_nterm; TIGR02456 762376010461 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 762376010462 active site 762376010463 catalytic site [active] 762376010464 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 762376010465 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 762376010466 glycogen branching enzyme; Provisional; Region: PRK05402 762376010467 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 762376010468 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 762376010469 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 762376010470 active site 762376010471 catalytic site [active] 762376010472 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 762376010473 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 762376010474 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 762376010475 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 762376010476 active site 762376010477 catalytic site [active] 762376010478 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 762376010479 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 762376010480 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 762376010481 catalytic site [active] 762376010482 active site 762376010483 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 762376010484 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 762376010485 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 762376010486 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 762376010487 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 762376010488 active site 762376010489 catalytic site [active] 762376010490 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 762376010491 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376010492 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 762376010493 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 762376010494 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376010495 Ligand Binding Site [chemical binding]; other site 762376010496 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762376010497 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 762376010498 putative ligand binding site [chemical binding]; other site 762376010499 NAD binding site [chemical binding]; other site 762376010500 catalytic site [active] 762376010501 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 762376010502 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 762376010503 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 762376010504 active site 762376010505 DNA binding site [nucleotide binding] 762376010506 Int/Topo IB signature motif; other site 762376010507 catalytic residues [active] 762376010508 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 762376010509 dimerization interface [polypeptide binding]; other site 762376010510 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 762376010511 short chain dehydrogenase; Provisional; Region: PRK06701 762376010512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376010513 NAD(P) binding site [chemical binding]; other site 762376010514 active site 762376010515 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 762376010516 Domain of unknown function (DUF378); Region: DUF378; pfam04070 762376010517 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 762376010518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376010519 active site 762376010520 phosphorylation site [posttranslational modification] 762376010521 intermolecular recognition site; other site 762376010522 dimerization interface [polypeptide binding]; other site 762376010523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376010524 Walker A motif; other site 762376010525 ATP binding site [chemical binding]; other site 762376010526 Walker B motif; other site 762376010527 arginine finger; other site 762376010528 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762376010529 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 762376010530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376010531 Walker A motif; other site 762376010532 ATP binding site [chemical binding]; other site 762376010533 Walker B motif; other site 762376010534 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762376010535 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 762376010536 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 762376010537 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 762376010538 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 762376010539 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 762376010540 GAF domain; Region: GAF; pfam01590 762376010541 PAS domain S-box; Region: sensory_box; TIGR00229 762376010542 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 762376010543 putative active site [active] 762376010544 heme pocket [chemical binding]; other site 762376010545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376010546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376010547 putative active site [active] 762376010548 heme pocket [chemical binding]; other site 762376010549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376010550 dimer interface [polypeptide binding]; other site 762376010551 phosphorylation site [posttranslational modification] 762376010552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376010553 ATP binding site [chemical binding]; other site 762376010554 Mg2+ binding site [ion binding]; other site 762376010555 G-X-G motif; other site 762376010556 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 762376010557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376010558 active site 762376010559 phosphorylation site [posttranslational modification] 762376010560 intermolecular recognition site; other site 762376010561 dimerization interface [polypeptide binding]; other site 762376010562 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 762376010563 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376010564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376010565 putative substrate translocation pore; other site 762376010566 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 762376010567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376010568 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 762376010569 putative dimerization interface [polypeptide binding]; other site 762376010570 putative substrate binding pocket [chemical binding]; other site 762376010571 conserved hypothetical protein; Region: TIGR02231 762376010572 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 762376010573 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 762376010574 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 762376010575 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 762376010576 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 762376010577 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 762376010578 FAD binding pocket [chemical binding]; other site 762376010579 FAD binding motif [chemical binding]; other site 762376010580 phosphate binding motif [ion binding]; other site 762376010581 beta-alpha-beta structure motif; other site 762376010582 NAD binding pocket [chemical binding]; other site 762376010583 Response regulator receiver domain; Region: Response_reg; pfam00072 762376010584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376010585 active site 762376010586 phosphorylation site [posttranslational modification] 762376010587 intermolecular recognition site; other site 762376010588 dimerization interface [polypeptide binding]; other site 762376010589 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376010590 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 762376010591 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 762376010592 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376010593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376010594 hydroxyglutarate oxidase; Provisional; Region: PRK11728 762376010595 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762376010596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762376010597 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376010598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376010599 active site 762376010600 phosphorylation site [posttranslational modification] 762376010601 intermolecular recognition site; other site 762376010602 dimerization interface [polypeptide binding]; other site 762376010603 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376010604 DNA binding site [nucleotide binding] 762376010605 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 762376010606 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 762376010607 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 762376010608 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762376010609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376010610 Walker A/P-loop; other site 762376010611 ATP binding site [chemical binding]; other site 762376010612 Q-loop/lid; other site 762376010613 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376010614 ABC transporter signature motif; other site 762376010615 Walker B; other site 762376010616 D-loop; other site 762376010617 ABC transporter; Region: ABC_tran_2; pfam12848 762376010618 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376010619 Sulfatase; Region: Sulfatase; cl17466 762376010620 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376010621 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376010622 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376010623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376010624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010625 dimerization interface [polypeptide binding]; other site 762376010626 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376010627 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 762376010628 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 762376010629 Cytochrome P450; Region: p450; cl12078 762376010630 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 762376010631 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 762376010632 FMN-binding pocket [chemical binding]; other site 762376010633 flavin binding motif; other site 762376010634 phosphate binding motif [ion binding]; other site 762376010635 beta-alpha-beta structure motif; other site 762376010636 NAD binding pocket [chemical binding]; other site 762376010637 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376010638 catalytic loop [active] 762376010639 iron binding site [ion binding]; other site 762376010640 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 762376010641 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 762376010642 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 762376010643 phosphate binding site [ion binding]; other site 762376010644 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762376010645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376010646 Coenzyme A binding pocket [chemical binding]; other site 762376010647 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 762376010648 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376010649 putative active site [active] 762376010650 putative metal binding site [ion binding]; other site 762376010651 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376010652 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 762376010653 putative DNA binding site [nucleotide binding]; other site 762376010654 putative Zn2+ binding site [ion binding]; other site 762376010655 AsnC family; Region: AsnC_trans_reg; pfam01037 762376010656 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376010657 PAS domain S-box; Region: sensory_box; TIGR00229 762376010658 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376010659 putative active site [active] 762376010660 heme pocket [chemical binding]; other site 762376010661 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376010662 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376010663 metal binding site [ion binding]; metal-binding site 762376010664 active site 762376010665 I-site; other site 762376010666 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 762376010667 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762376010668 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 762376010669 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376010670 inhibitor-cofactor binding pocket; inhibition site 762376010671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376010672 catalytic residue [active] 762376010673 Arginase family; Region: Arginase; cd09989 762376010674 agmatinase; Region: agmatinase; TIGR01230 762376010675 active site 762376010676 Mn binding site [ion binding]; other site 762376010677 oligomer interface [polypeptide binding]; other site 762376010678 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376010679 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376010680 putative ligand binding site [chemical binding]; other site 762376010681 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 762376010682 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 762376010683 putative NAD(P) binding site [chemical binding]; other site 762376010684 catalytic Zn binding site [ion binding]; other site 762376010685 RES domain; Region: RES; cl02411 762376010686 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 762376010687 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 762376010688 Protein of unknown function (DUF423); Region: DUF423; pfam04241 762376010689 EamA-like transporter family; Region: EamA; pfam00892 762376010690 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376010691 EamA-like transporter family; Region: EamA; pfam00892 762376010692 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376010693 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376010694 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 762376010695 dimer interface [polypeptide binding]; other site 762376010696 N-terminal domain interface [polypeptide binding]; other site 762376010697 substrate binding pocket (H-site) [chemical binding]; other site 762376010698 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 762376010699 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 762376010700 glutathionine S-transferase; Provisional; Region: PRK10542 762376010701 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 762376010702 C-terminal domain interface [polypeptide binding]; other site 762376010703 GSH binding site (G-site) [chemical binding]; other site 762376010704 dimer interface [polypeptide binding]; other site 762376010705 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 762376010706 dimer interface [polypeptide binding]; other site 762376010707 N-terminal domain interface [polypeptide binding]; other site 762376010708 substrate binding pocket (H-site) [chemical binding]; other site 762376010709 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376010710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376010711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010712 dimerization interface [polypeptide binding]; other site 762376010713 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376010714 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 762376010715 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 762376010716 active site 762376010717 putative substrate binding pocket [chemical binding]; other site 762376010718 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376010719 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376010720 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376010721 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376010722 Walker A/P-loop; other site 762376010723 ATP binding site [chemical binding]; other site 762376010724 Q-loop/lid; other site 762376010725 ABC transporter signature motif; other site 762376010726 Walker B; other site 762376010727 D-loop; other site 762376010728 H-loop/switch region; other site 762376010729 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 762376010730 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376010731 Walker A/P-loop; other site 762376010732 ATP binding site [chemical binding]; other site 762376010733 Q-loop/lid; other site 762376010734 ABC transporter signature motif; other site 762376010735 Walker B; other site 762376010736 D-loop; other site 762376010737 H-loop/switch region; other site 762376010738 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 762376010739 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 762376010740 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376010741 TM-ABC transporter signature motif; other site 762376010742 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376010743 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376010744 TM-ABC transporter signature motif; other site 762376010745 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376010746 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 762376010747 dimerization interface [polypeptide binding]; other site 762376010748 ligand binding site [chemical binding]; other site 762376010749 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 762376010750 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 762376010751 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 762376010752 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762376010753 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762376010754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376010755 dimer interface [polypeptide binding]; other site 762376010756 conserved gate region; other site 762376010757 ABC-ATPase subunit interface; other site 762376010758 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 762376010759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376010760 dimer interface [polypeptide binding]; other site 762376010761 conserved gate region; other site 762376010762 putative PBP binding loops; other site 762376010763 ABC-ATPase subunit interface; other site 762376010764 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 762376010765 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 762376010766 Walker A/P-loop; other site 762376010767 ATP binding site [chemical binding]; other site 762376010768 Q-loop/lid; other site 762376010769 ABC transporter signature motif; other site 762376010770 Walker B; other site 762376010771 D-loop; other site 762376010772 H-loop/switch region; other site 762376010773 TOBE domain; Region: TOBE_2; pfam08402 762376010774 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 762376010775 Beta-lactamase; Region: Beta-lactamase; pfam00144 762376010776 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 762376010777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376010778 dimerization interface [polypeptide binding]; other site 762376010779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376010780 dimer interface [polypeptide binding]; other site 762376010781 phosphorylation site [posttranslational modification] 762376010782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376010783 ATP binding site [chemical binding]; other site 762376010784 Mg2+ binding site [ion binding]; other site 762376010785 G-X-G motif; other site 762376010786 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 762376010787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376010788 active site 762376010789 phosphorylation site [posttranslational modification] 762376010790 intermolecular recognition site; other site 762376010791 dimerization interface [polypeptide binding]; other site 762376010792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376010793 DNA binding site [nucleotide binding] 762376010794 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376010795 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 762376010796 dimerization interface [polypeptide binding]; other site 762376010797 ligand binding site [chemical binding]; other site 762376010798 Serine hydrolase; Region: Ser_hydrolase; pfam06821 762376010799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376010800 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 762376010801 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 762376010802 dimerization interface [polypeptide binding]; other site 762376010803 DPS ferroxidase diiron center [ion binding]; other site 762376010804 ion pore; other site 762376010805 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 762376010806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376010807 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 762376010808 dimerization interface [polypeptide binding]; other site 762376010809 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 762376010810 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 762376010811 generic binding surface II; other site 762376010812 ssDNA binding site; other site 762376010813 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376010814 ATP binding site [chemical binding]; other site 762376010815 putative Mg++ binding site [ion binding]; other site 762376010816 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376010817 nucleotide binding region [chemical binding]; other site 762376010818 ATP-binding site [chemical binding]; other site 762376010819 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376010820 homotrimer interaction site [polypeptide binding]; other site 762376010821 putative active site [active] 762376010822 Fic/DOC family; Region: Fic; cl00960 762376010823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376010824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376010825 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376010826 putative dimerization interface [polypeptide binding]; other site 762376010827 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 762376010828 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376010829 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 762376010830 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 762376010831 FAD binding pocket [chemical binding]; other site 762376010832 FAD binding motif [chemical binding]; other site 762376010833 phosphate binding motif [ion binding]; other site 762376010834 beta-alpha-beta structure motif; other site 762376010835 NAD binding pocket [chemical binding]; other site 762376010836 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 762376010837 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 762376010838 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 762376010839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376010840 dimer interface [polypeptide binding]; other site 762376010841 conserved gate region; other site 762376010842 putative PBP binding loops; other site 762376010843 ABC-ATPase subunit interface; other site 762376010844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376010845 dimer interface [polypeptide binding]; other site 762376010846 conserved gate region; other site 762376010847 putative PBP binding loops; other site 762376010848 ABC-ATPase subunit interface; other site 762376010849 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 762376010850 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 762376010851 Walker A/P-loop; other site 762376010852 ATP binding site [chemical binding]; other site 762376010853 Q-loop/lid; other site 762376010854 ABC transporter signature motif; other site 762376010855 Walker B; other site 762376010856 D-loop; other site 762376010857 H-loop/switch region; other site 762376010858 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376010859 Pirin-related protein [General function prediction only]; Region: COG1741 762376010860 Pirin; Region: Pirin; pfam02678 762376010861 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 762376010862 Pirin-related protein [General function prediction only]; Region: COG1741 762376010863 Pirin; Region: Pirin; pfam02678 762376010864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376010865 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 762376010866 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376010867 dimerization interface [polypeptide binding]; other site 762376010868 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 762376010869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376010870 active site 762376010871 phosphorylation site [posttranslational modification] 762376010872 intermolecular recognition site; other site 762376010873 dimerization interface [polypeptide binding]; other site 762376010874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376010875 Walker A motif; other site 762376010876 ATP binding site [chemical binding]; other site 762376010877 Walker B motif; other site 762376010878 arginine finger; other site 762376010879 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762376010880 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 762376010881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376010882 putative active site [active] 762376010883 heme pocket [chemical binding]; other site 762376010884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376010885 dimer interface [polypeptide binding]; other site 762376010886 phosphorylation site [posttranslational modification] 762376010887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376010888 ATP binding site [chemical binding]; other site 762376010889 Mg2+ binding site [ion binding]; other site 762376010890 G-X-G motif; other site 762376010891 glutamine synthetase; Provisional; Region: glnA; PRK09469 762376010892 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 762376010893 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 762376010894 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 762376010895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762376010896 FeS/SAM binding site; other site 762376010897 HemN C-terminal domain; Region: HemN_C; pfam06969 762376010898 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 762376010899 active site 762376010900 dimerization interface [polypeptide binding]; other site 762376010901 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376010902 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 762376010903 FOG: CBS domain [General function prediction only]; Region: COG0517 762376010904 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376010905 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376010906 metal binding site [ion binding]; metal-binding site 762376010907 active site 762376010908 I-site; other site 762376010909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376010910 dimerization interface [polypeptide binding]; other site 762376010911 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376010912 dimer interface [polypeptide binding]; other site 762376010913 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 762376010914 putative CheW interface [polypeptide binding]; other site 762376010915 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376010916 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376010917 active site 762376010918 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 762376010919 ribonuclease PH; Reviewed; Region: rph; PRK00173 762376010920 Ribonuclease PH; Region: RNase_PH_bact; cd11362 762376010921 hexamer interface [polypeptide binding]; other site 762376010922 active site 762376010923 hypothetical protein; Provisional; Region: PRK11820 762376010924 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 762376010925 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 762376010926 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 762376010927 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 762376010928 lysine transporter; Provisional; Region: PRK10836 762376010929 AMP nucleosidase; Provisional; Region: PRK08292 762376010930 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 762376010931 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 762376010932 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 762376010933 NlpC/P60 family; Region: NLPC_P60; pfam00877 762376010934 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 762376010935 classical (c) SDRs; Region: SDR_c; cd05233 762376010936 NAD(P) binding site [chemical binding]; other site 762376010937 active site 762376010938 Cytochrome c; Region: Cytochrom_C; cl11414 762376010939 Cytochrome c; Region: Cytochrom_C; cl11414 762376010940 Cytochrome c [Energy production and conversion]; Region: COG3258 762376010941 Cytochrome c; Region: Cytochrom_C; pfam00034 762376010942 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 762376010943 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 762376010944 catalytic site [active] 762376010945 G-X2-G-X-G-K; other site 762376010946 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 762376010947 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 762376010948 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762376010949 Zn2+ binding site [ion binding]; other site 762376010950 Mg2+ binding site [ion binding]; other site 762376010951 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 762376010952 synthetase active site [active] 762376010953 NTP binding site [chemical binding]; other site 762376010954 metal binding site [ion binding]; metal-binding site 762376010955 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 762376010956 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 762376010957 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 762376010958 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376010959 Walker A/P-loop; other site 762376010960 ATP binding site [chemical binding]; other site 762376010961 Q-loop/lid; other site 762376010962 ABC transporter signature motif; other site 762376010963 Walker B; other site 762376010964 D-loop; other site 762376010965 H-loop/switch region; other site 762376010966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376010967 dimer interface [polypeptide binding]; other site 762376010968 conserved gate region; other site 762376010969 putative PBP binding loops; other site 762376010970 ABC-ATPase subunit interface; other site 762376010971 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 762376010972 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376010973 substrate binding pocket [chemical binding]; other site 762376010974 membrane-bound complex binding site; other site 762376010975 hinge residues; other site 762376010976 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 762376010977 5-oxoprolinase; Region: PLN02666 762376010978 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 762376010979 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 762376010980 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 762376010981 MarR family; Region: MarR_2; cl17246 762376010982 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 762376010983 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 762376010984 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 762376010985 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 762376010986 putative NADH binding site [chemical binding]; other site 762376010987 putative active site [active] 762376010988 nudix motif; other site 762376010989 putative metal binding site [ion binding]; other site 762376010990 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 762376010991 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 762376010992 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 762376010993 DctM-like transporters; Region: DctM; pfam06808 762376010994 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 762376010995 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 762376010996 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 762376010997 trimer interface [polypeptide binding]; other site 762376010998 eyelet of channel; other site 762376010999 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376011000 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376011001 Walker A/P-loop; other site 762376011002 ATP binding site [chemical binding]; other site 762376011003 Q-loop/lid; other site 762376011004 ABC transporter signature motif; other site 762376011005 Walker B; other site 762376011006 D-loop; other site 762376011007 H-loop/switch region; other site 762376011008 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376011009 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376011010 Walker A/P-loop; other site 762376011011 ATP binding site [chemical binding]; other site 762376011012 Q-loop/lid; other site 762376011013 ABC transporter signature motif; other site 762376011014 Walker B; other site 762376011015 D-loop; other site 762376011016 H-loop/switch region; other site 762376011017 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376011018 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376011019 TM-ABC transporter signature motif; other site 762376011020 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376011021 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376011022 TM-ABC transporter signature motif; other site 762376011023 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376011024 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 762376011025 putative ligand binding site [chemical binding]; other site 762376011026 hypothetical protein; Provisional; Region: PRK05463 762376011027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011028 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 762376011029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376011030 dimerization interface [polypeptide binding]; other site 762376011031 amidase; Provisional; Region: PRK07056 762376011032 Amidase; Region: Amidase; cl11426 762376011033 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 762376011034 DctM-like transporters; Region: DctM; pfam06808 762376011035 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 762376011036 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 762376011037 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 762376011038 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011039 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011040 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376011041 dimerization interface [polypeptide binding]; other site 762376011042 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376011043 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 762376011044 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 762376011045 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 762376011046 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 762376011047 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 762376011048 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 762376011049 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376011050 motif II; other site 762376011051 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376011052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011053 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376011054 dimerization interface [polypeptide binding]; other site 762376011055 substrate binding pocket [chemical binding]; other site 762376011056 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376011057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376011058 Walker A/P-loop; other site 762376011059 ATP binding site [chemical binding]; other site 762376011060 Q-loop/lid; other site 762376011061 ABC transporter signature motif; other site 762376011062 Walker B; other site 762376011063 D-loop; other site 762376011064 H-loop/switch region; other site 762376011065 TOBE domain; Region: TOBE_2; pfam08402 762376011066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 762376011067 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 762376011068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376011069 dimer interface [polypeptide binding]; other site 762376011070 conserved gate region; other site 762376011071 putative PBP binding loops; other site 762376011072 ABC-ATPase subunit interface; other site 762376011073 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 762376011074 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 762376011075 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 762376011076 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762376011077 Walker A/P-loop; other site 762376011078 ATP binding site [chemical binding]; other site 762376011079 Q-loop/lid; other site 762376011080 ABC transporter signature motif; other site 762376011081 Walker B; other site 762376011082 D-loop; other site 762376011083 H-loop/switch region; other site 762376011084 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 762376011085 active site 762376011086 catalytic triad [active] 762376011087 oxyanion hole [active] 762376011088 switch loop; other site 762376011089 SurA N-terminal domain; Region: SurA_N_3; pfam13624 762376011090 periplasmic folding chaperone; Provisional; Region: PRK10788 762376011091 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 762376011092 glutamate carboxypeptidase; Reviewed; Region: PRK06133 762376011093 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 762376011094 metal binding site [ion binding]; metal-binding site 762376011095 dimer interface [polypeptide binding]; other site 762376011096 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 762376011097 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 762376011098 putative active site [active] 762376011099 catalytic site [active] 762376011100 putative metal binding site [ion binding]; other site 762376011101 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 762376011102 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 762376011103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376011104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376011105 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376011106 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 762376011107 catalytic triad [active] 762376011108 dimer interface [polypeptide binding]; other site 762376011109 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376011110 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376011111 metal-binding site [ion binding] 762376011112 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 762376011113 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 762376011114 DNA binding residues [nucleotide binding] 762376011115 dimer interface [polypeptide binding]; other site 762376011116 copper binding site [ion binding]; other site 762376011117 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 762376011118 TRAM domain; Region: TRAM; cl01282 762376011119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376011120 S-adenosylmethionine binding site [chemical binding]; other site 762376011121 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376011122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011123 putative substrate translocation pore; other site 762376011124 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376011125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011126 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376011127 dimerization interface [polypeptide binding]; other site 762376011128 substrate binding pocket [chemical binding]; other site 762376011129 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 762376011130 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 762376011131 active site 762376011132 catalytic site [active] 762376011133 substrate binding site [chemical binding]; other site 762376011134 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 762376011135 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 762376011136 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762376011137 Peptidase family M23; Region: Peptidase_M23; pfam01551 762376011138 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 762376011139 Methyltransferase domain; Region: Methyltransf_18; pfam12847 762376011140 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 762376011141 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 762376011142 UGMP family protein; Validated; Region: PRK09604 762376011143 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 762376011144 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 762376011145 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 762376011146 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 762376011147 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 762376011148 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762376011149 catalytic residues [active] 762376011150 Uncharacterized conserved protein [Function unknown]; Region: COG1739 762376011151 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 762376011152 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 762376011153 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376011154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376011155 dimer interface [polypeptide binding]; other site 762376011156 conserved gate region; other site 762376011157 putative PBP binding loops; other site 762376011158 ABC-ATPase subunit interface; other site 762376011159 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 762376011160 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 762376011161 substrate binding pocket [chemical binding]; other site 762376011162 membrane-bound complex binding site; other site 762376011163 hinge residues; other site 762376011164 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376011165 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762376011166 Walker A/P-loop; other site 762376011167 ATP binding site [chemical binding]; other site 762376011168 Q-loop/lid; other site 762376011169 ABC transporter signature motif; other site 762376011170 Walker B; other site 762376011171 D-loop; other site 762376011172 H-loop/switch region; other site 762376011173 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376011174 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376011175 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376011176 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 762376011177 putative active site [active] 762376011178 putative catalytic site [active] 762376011179 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376011180 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376011181 substrate binding site [chemical binding]; other site 762376011182 oxyanion hole (OAH) forming residues; other site 762376011183 trimer interface [polypeptide binding]; other site 762376011184 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376011185 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376011186 thiolase; Provisional; Region: PRK06158 762376011187 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376011188 active site 762376011189 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376011190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376011191 NAD(P) binding site [chemical binding]; other site 762376011192 active site 762376011193 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 762376011194 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376011195 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376011196 ABC transporter; Region: ABC_tran_2; pfam12848 762376011197 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376011198 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 762376011199 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 762376011200 NADP binding site [chemical binding]; other site 762376011201 dimer interface [polypeptide binding]; other site 762376011202 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 762376011203 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376011204 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376011205 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376011206 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011208 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011209 dimerization interface [polypeptide binding]; other site 762376011210 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 762376011211 dimer interface [polypeptide binding]; other site 762376011212 catalytic triad [active] 762376011213 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 762376011214 nucleoside/Zn binding site; other site 762376011215 dimer interface [polypeptide binding]; other site 762376011216 catalytic motif [active] 762376011217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 762376011218 motif II; other site 762376011219 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 762376011220 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 762376011221 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 762376011222 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 762376011223 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 762376011224 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 762376011225 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 762376011226 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 762376011227 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 762376011228 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 762376011229 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376011230 Protein of unknown function (DUF342); Region: DUF342; pfam03961 762376011231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011232 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376011233 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376011234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376011235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376011236 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 762376011237 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376011238 active site 762376011239 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376011240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376011241 Walker A/P-loop; other site 762376011242 ATP binding site [chemical binding]; other site 762376011243 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376011244 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 762376011245 active site 762376011246 metal binding site [ion binding]; metal-binding site 762376011247 DNA binding site [nucleotide binding] 762376011248 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376011249 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376011250 active site 762376011251 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376011252 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376011253 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376011254 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376011255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011257 dimerization interface [polypeptide binding]; other site 762376011258 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 762376011259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376011260 hydroxyglutarate oxidase; Provisional; Region: PRK11728 762376011261 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 762376011262 putative DNA binding site [nucleotide binding]; other site 762376011263 putative Zn2+ binding site [ion binding]; other site 762376011264 AsnC family; Region: AsnC_trans_reg; pfam01037 762376011265 Protein of unknown function (DUF502); Region: DUF502; cl01107 762376011266 S4 domain; Region: S4_2; pfam13275 762376011267 Restriction endonuclease; Region: Mrr_cat; pfam04471 762376011268 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 762376011269 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376011270 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376011271 active site 762376011272 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 762376011273 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 762376011274 glucose-1-dehydrogenase; Provisional; Region: PRK08936 762376011275 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 762376011276 NAD binding site [chemical binding]; other site 762376011277 homodimer interface [polypeptide binding]; other site 762376011278 active site 762376011279 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 762376011280 GAF domain; Region: GAF; pfam01590 762376011281 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376011282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376011283 metal binding site [ion binding]; metal-binding site 762376011284 active site 762376011285 I-site; other site 762376011286 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 762376011287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376011288 substrate binding pocket [chemical binding]; other site 762376011289 hinge residues; other site 762376011290 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762376011291 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376011292 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 762376011293 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376011294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011296 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376011297 putative dimerization interface [polypeptide binding]; other site 762376011298 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762376011299 PGAP1-like protein; Region: PGAP1; pfam07819 762376011300 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762376011301 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 762376011302 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 762376011303 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 762376011304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376011305 dimer interface [polypeptide binding]; other site 762376011306 conserved gate region; other site 762376011307 putative PBP binding loops; other site 762376011308 ABC-ATPase subunit interface; other site 762376011309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376011310 dimer interface [polypeptide binding]; other site 762376011311 putative PBP binding loops; other site 762376011312 ABC-ATPase subunit interface; other site 762376011313 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 762376011314 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 762376011315 Walker A/P-loop; other site 762376011316 ATP binding site [chemical binding]; other site 762376011317 Q-loop/lid; other site 762376011318 ABC transporter signature motif; other site 762376011319 Walker B; other site 762376011320 D-loop; other site 762376011321 H-loop/switch region; other site 762376011322 TOBE domain; Region: TOBE_2; pfam08402 762376011323 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 762376011324 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 762376011325 Walker A/P-loop; other site 762376011326 ATP binding site [chemical binding]; other site 762376011327 Q-loop/lid; other site 762376011328 ABC transporter signature motif; other site 762376011329 Walker B; other site 762376011330 D-loop; other site 762376011331 H-loop/switch region; other site 762376011332 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 762376011333 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 762376011334 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 762376011335 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 762376011336 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762376011337 Zn2+ binding site [ion binding]; other site 762376011338 Mg2+ binding site [ion binding]; other site 762376011339 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 762376011340 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 762376011341 potential catalytic triad [active] 762376011342 conserved cys residue [active] 762376011343 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 762376011344 Prostaglandin dehydrogenases; Region: PGDH; cd05288 762376011345 NAD(P) binding site [chemical binding]; other site 762376011346 substrate binding site [chemical binding]; other site 762376011347 dimer interface [polypeptide binding]; other site 762376011348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376011349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376011350 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376011351 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376011352 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762376011353 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762376011354 Walker A/P-loop; other site 762376011355 ATP binding site [chemical binding]; other site 762376011356 Q-loop/lid; other site 762376011357 ABC transporter signature motif; other site 762376011358 Walker B; other site 762376011359 D-loop; other site 762376011360 H-loop/switch region; other site 762376011361 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762376011362 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 762376011363 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 762376011364 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 762376011365 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 762376011366 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376011367 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 762376011368 DNA binding site [nucleotide binding] 762376011369 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 762376011370 putative deacylase active site [active] 762376011371 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 762376011372 NRDE protein; Region: NRDE; cl01315 762376011373 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 762376011374 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 762376011375 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 762376011376 active site 762376011377 catalytic site [active] 762376011378 MAPEG family; Region: MAPEG; cl09190 762376011379 CAAX protease self-immunity; Region: Abi; pfam02517 762376011380 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762376011381 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 762376011382 FMN binding site [chemical binding]; other site 762376011383 active site 762376011384 substrate binding site [chemical binding]; other site 762376011385 catalytic residue [active] 762376011386 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376011387 dimerization interface [polypeptide binding]; other site 762376011388 putative DNA binding site [nucleotide binding]; other site 762376011389 putative Zn2+ binding site [ion binding]; other site 762376011390 amidase; Provisional; Region: PRK07487 762376011391 Amidase; Region: Amidase; cl11426 762376011392 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376011393 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 762376011394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011396 dimerization interface [polypeptide binding]; other site 762376011397 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 762376011398 hypothetical protein; Provisional; Region: PRK09256 762376011399 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 762376011400 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 762376011401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762376011402 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 762376011403 active site 762376011404 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376011405 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 762376011406 Fusaric acid resistance protein family; Region: FUSC; pfam04632 762376011407 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 762376011408 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 762376011409 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376011410 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376011411 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 762376011412 Predicted esterase [General function prediction only]; Region: COG0400 762376011413 putative hydrolase; Provisional; Region: PRK11460 762376011414 lysine transporter; Provisional; Region: PRK10836 762376011415 Uncharacterized conserved protein [Function unknown]; Region: COG4544 762376011416 DNA Polymerase Y-family; Region: PolY_like; cd03468 762376011417 active site 762376011418 DNA binding site [nucleotide binding] 762376011419 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 762376011420 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 762376011421 putative active site [active] 762376011422 putative PHP Thumb interface [polypeptide binding]; other site 762376011423 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 762376011424 generic binding surface II; other site 762376011425 generic binding surface I; other site 762376011426 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 762376011427 active site 762376011428 catalytic triad [active] 762376011429 oxyanion hole [active] 762376011430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011432 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376011433 putative effector binding pocket; other site 762376011434 dimerization interface [polypeptide binding]; other site 762376011435 peptidase; Reviewed; Region: PRK13004 762376011436 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762376011437 metal binding site [ion binding]; metal-binding site 762376011438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011439 D-galactonate transporter; Region: 2A0114; TIGR00893 762376011440 putative substrate translocation pore; other site 762376011441 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 762376011442 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762376011443 tetramer interface [polypeptide binding]; other site 762376011444 active site 762376011445 catalytic triad [active] 762376011446 dimer interface [polypeptide binding]; other site 762376011447 allantoate amidohydrolase; Reviewed; Region: PRK12893 762376011448 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762376011449 active site 762376011450 metal binding site [ion binding]; metal-binding site 762376011451 dimer interface [polypeptide binding]; other site 762376011452 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 762376011453 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 762376011454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376011455 catalytic residue [active] 762376011456 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376011457 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 762376011458 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 762376011459 putative active site [active] 762376011460 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 762376011461 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376011464 dimerization interface [polypeptide binding]; other site 762376011465 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376011466 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376011467 Walker A/P-loop; other site 762376011468 ATP binding site [chemical binding]; other site 762376011469 Q-loop/lid; other site 762376011470 ABC transporter signature motif; other site 762376011471 Walker B; other site 762376011472 D-loop; other site 762376011473 H-loop/switch region; other site 762376011474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376011475 dimer interface [polypeptide binding]; other site 762376011476 conserved gate region; other site 762376011477 putative PBP binding loops; other site 762376011478 ABC-ATPase subunit interface; other site 762376011479 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376011480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376011481 dimer interface [polypeptide binding]; other site 762376011482 conserved gate region; other site 762376011483 putative PBP binding loops; other site 762376011484 ABC-ATPase subunit interface; other site 762376011485 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376011486 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376011487 substrate binding pocket [chemical binding]; other site 762376011488 membrane-bound complex binding site; other site 762376011489 hinge residues; other site 762376011490 aspartate aminotransferase; Provisional; Region: PRK05764 762376011491 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376011492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376011493 homodimer interface [polypeptide binding]; other site 762376011494 catalytic residue [active] 762376011495 hypothetical protein; Validated; Region: PRK06201 762376011496 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 762376011497 Cupin; Region: Cupin_6; pfam12852 762376011498 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376011499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376011500 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 762376011501 Cytochrome P450; Region: p450; cl12078 762376011502 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 762376011503 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 762376011504 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 762376011505 FMN-binding pocket [chemical binding]; other site 762376011506 flavin binding motif; other site 762376011507 phosphate binding motif [ion binding]; other site 762376011508 beta-alpha-beta structure motif; other site 762376011509 NAD binding pocket [chemical binding]; other site 762376011510 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376011511 catalytic loop [active] 762376011512 iron binding site [ion binding]; other site 762376011513 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376011514 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376011515 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u11; cd10942 762376011516 putative active site [active] 762376011517 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 762376011518 Integrase core domain; Region: rve_3; cl15866 762376011519 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 762376011520 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 762376011521 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376011522 active site 762376011523 HIGH motif; other site 762376011524 nucleotide binding site [chemical binding]; other site 762376011525 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376011526 active site 762376011527 KMSKS motif; other site 762376011528 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762376011529 tRNA binding surface [nucleotide binding]; other site 762376011530 anticodon binding site; other site 762376011531 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464 762376011532 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 762376011533 FeS/SAM binding site; other site 762376011534 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 762376011535 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 762376011536 Cytochrome c; Region: Cytochrom_C; pfam00034 762376011537 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011539 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 762376011540 putative effector binding pocket; other site 762376011541 putative dimerization interface [polypeptide binding]; other site 762376011542 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 762376011543 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 762376011544 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762376011545 putative NAD(P) binding site [chemical binding]; other site 762376011546 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 762376011547 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762376011548 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762376011549 Uncharacterized conserved protein [Function unknown]; Region: COG3791 762376011550 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 762376011551 dimer interface [polypeptide binding]; other site 762376011552 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376011553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011554 putative substrate translocation pore; other site 762376011555 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376011556 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 762376011557 metal binding site [ion binding]; metal-binding site 762376011558 putative dimer interface [polypeptide binding]; other site 762376011559 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376011560 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376011561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376011562 DNA-binding site [nucleotide binding]; DNA binding site 762376011563 FCD domain; Region: FCD; pfam07729 762376011564 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376011565 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 762376011566 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376011567 choline dehydrogenase; Validated; Region: PRK02106 762376011568 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376011569 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376011570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011571 putative substrate translocation pore; other site 762376011572 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762376011573 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762376011574 active site 762376011575 catalytic tetrad [active] 762376011576 Beta-lactamase; Region: Beta-lactamase; pfam00144 762376011577 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 762376011578 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 762376011579 homodimer interface [polypeptide binding]; other site 762376011580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376011581 catalytic residue [active] 762376011582 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376011583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376011584 DNA-binding site [nucleotide binding]; DNA binding site 762376011585 FCD domain; Region: FCD; pfam07729 762376011586 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 762376011587 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376011588 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376011589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376011590 dimer interface [polypeptide binding]; other site 762376011591 conserved gate region; other site 762376011592 putative PBP binding loops; other site 762376011593 ABC-ATPase subunit interface; other site 762376011594 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376011595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376011596 dimer interface [polypeptide binding]; other site 762376011597 conserved gate region; other site 762376011598 putative PBP binding loops; other site 762376011599 ABC-ATPase subunit interface; other site 762376011600 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376011601 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376011602 Walker A/P-loop; other site 762376011603 ATP binding site [chemical binding]; other site 762376011604 Q-loop/lid; other site 762376011605 ABC transporter signature motif; other site 762376011606 Walker B; other site 762376011607 D-loop; other site 762376011608 H-loop/switch region; other site 762376011609 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376011610 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376011611 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376011612 Walker A/P-loop; other site 762376011613 ATP binding site [chemical binding]; other site 762376011614 Q-loop/lid; other site 762376011615 ABC transporter signature motif; other site 762376011616 Walker B; other site 762376011617 D-loop; other site 762376011618 H-loop/switch region; other site 762376011619 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376011620 hypothetical protein; Provisional; Region: PRK07079 762376011621 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 762376011622 metal binding site [ion binding]; metal-binding site 762376011623 putative dimer interface [polypeptide binding]; other site 762376011624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011626 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376011627 putative effector binding pocket; other site 762376011628 dimerization interface [polypeptide binding]; other site 762376011629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 762376011630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376011631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376011632 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 762376011633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376011634 Uncharacterized conserved protein [Function unknown]; Region: COG1683 762376011635 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376011636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376011637 Uncharacterized conserved protein [Function unknown]; Region: COG1432 762376011638 LabA_like proteins; Region: LabA_like; cd06167 762376011639 putative metal binding site [ion binding]; other site 762376011640 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 762376011641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762376011642 flagellar motor protein MotA; Validated; Region: PRK08124 762376011643 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 762376011644 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376011645 ligand binding site [chemical binding]; other site 762376011646 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 762376011647 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376011648 ligand binding site [chemical binding]; other site 762376011649 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 762376011650 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376011651 Uncharacterized conserved protein [Function unknown]; Region: COG5361 762376011652 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 762376011653 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 762376011654 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376011655 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376011656 putative DNA binding site [nucleotide binding]; other site 762376011657 putative Zn2+ binding site [ion binding]; other site 762376011658 AsnC family; Region: AsnC_trans_reg; pfam01037 762376011659 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376011660 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 762376011661 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 762376011662 high affinity sulphate transporter 1; Region: sulP; TIGR00815 762376011663 Sulfate transporter family; Region: Sulfate_transp; pfam00916 762376011664 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 762376011665 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 762376011666 YCII-related domain; Region: YCII; cl00999 762376011667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 762376011668 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 762376011669 putative hydrophobic ligand binding site [chemical binding]; other site 762376011670 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 762376011671 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376011672 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 762376011673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376011674 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 762376011675 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376011676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376011677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376011678 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376011679 EamA-like transporter family; Region: EamA; pfam00892 762376011680 EamA-like transporter family; Region: EamA; pfam00892 762376011681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011682 putative substrate translocation pore; other site 762376011683 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 762376011684 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011686 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011687 dimerization interface [polypeptide binding]; other site 762376011688 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 762376011689 short chain dehydrogenase; Provisional; Region: PRK06500 762376011690 classical (c) SDRs; Region: SDR_c; cd05233 762376011691 NAD(P) binding site [chemical binding]; other site 762376011692 active site 762376011693 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 762376011694 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376011695 MarR family; Region: MarR; pfam01047 762376011696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762376011697 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762376011698 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 762376011699 dimer interface [polypeptide binding]; other site 762376011700 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376011701 ligand binding site [chemical binding]; other site 762376011702 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 762376011703 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 762376011704 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 762376011705 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 762376011706 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 762376011707 tetracycline repressor protein TetR; Provisional; Region: PRK13756 762376011708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376011709 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 762376011710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011711 putative substrate translocation pore; other site 762376011712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376011713 PQQ-like domain; Region: PQQ_2; pfam13360 762376011714 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376011715 dimer interface [polypeptide binding]; other site 762376011716 phosphorylation site [posttranslational modification] 762376011717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376011718 ATP binding site [chemical binding]; other site 762376011719 Mg2+ binding site [ion binding]; other site 762376011720 G-X-G motif; other site 762376011721 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376011722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376011723 active site 762376011724 phosphorylation site [posttranslational modification] 762376011725 intermolecular recognition site; other site 762376011726 dimerization interface [polypeptide binding]; other site 762376011727 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376011728 DNA binding site [nucleotide binding] 762376011729 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 762376011730 active sites [active] 762376011731 tetramer interface [polypeptide binding]; other site 762376011732 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376011733 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 762376011734 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 762376011735 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 762376011736 transcriptional regulator; Provisional; Region: PRK10632 762376011737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011738 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376011739 putative effector binding pocket; other site 762376011740 dimerization interface [polypeptide binding]; other site 762376011741 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 762376011742 Domain of unknown function (DUF802); Region: DUF802; pfam05650 762376011743 Domain of unknown function (DUF802); Region: DUF802; pfam05650 762376011744 hypothetical protein; Provisional; Region: PRK09040 762376011745 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376011746 ligand binding site [chemical binding]; other site 762376011747 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 762376011748 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 762376011749 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 762376011750 active site 762376011751 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376011752 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376011753 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 762376011754 putative C-terminal domain interface [polypeptide binding]; other site 762376011755 putative GSH binding site (G-site) [chemical binding]; other site 762376011756 putative dimer interface [polypeptide binding]; other site 762376011757 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 762376011758 putative N-terminal domain interface [polypeptide binding]; other site 762376011759 putative dimer interface [polypeptide binding]; other site 762376011760 putative substrate binding pocket (H-site) [chemical binding]; other site 762376011761 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 762376011762 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 762376011763 E-class dimer interface [polypeptide binding]; other site 762376011764 P-class dimer interface [polypeptide binding]; other site 762376011765 active site 762376011766 Cu2+ binding site [ion binding]; other site 762376011767 Zn2+ binding site [ion binding]; other site 762376011768 Predicted membrane protein [Function unknown]; Region: COG2733 762376011769 GntP family permease; Region: GntP_permease; pfam02447 762376011770 fructuronate transporter; Provisional; Region: PRK10034; cl15264 762376011771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011773 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376011774 putative effector binding pocket; other site 762376011775 dimerization interface [polypeptide binding]; other site 762376011776 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 762376011777 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376011778 substrate binding site [chemical binding]; other site 762376011779 oxyanion hole (OAH) forming residues; other site 762376011780 trimer interface [polypeptide binding]; other site 762376011781 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376011782 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376011783 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376011784 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 762376011785 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376011786 dimer interface [polypeptide binding]; other site 762376011787 active site 762376011788 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376011789 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376011790 active site 762376011791 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376011792 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376011793 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376011794 active site 762376011795 AMP-binding domain protein; Validated; Region: PRK07529 762376011796 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376011797 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 762376011798 acyl-activating enzyme (AAE) consensus motif; other site 762376011799 putative AMP binding site [chemical binding]; other site 762376011800 putative active site [active] 762376011801 putative CoA binding site [chemical binding]; other site 762376011802 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376011803 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376011804 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762376011805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376011806 Walker A/P-loop; other site 762376011807 ATP binding site [chemical binding]; other site 762376011808 Q-loop/lid; other site 762376011809 ABC transporter signature motif; other site 762376011810 Walker B; other site 762376011811 D-loop; other site 762376011812 H-loop/switch region; other site 762376011813 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 762376011814 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376011815 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376011816 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376011817 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376011818 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376011819 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376011820 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376011821 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 762376011822 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 762376011823 Autotransporter beta-domain; Region: Autotransporter; pfam03797 762376011824 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 762376011825 putative NAD(P) binding site [chemical binding]; other site 762376011826 homodimer interface [polypeptide binding]; other site 762376011827 transcriptional regulator; Provisional; Region: PRK10632 762376011828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011829 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 762376011830 putative effector binding pocket; other site 762376011831 putative dimerization interface [polypeptide binding]; other site 762376011832 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376011833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011834 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376011835 dimerization interface [polypeptide binding]; other site 762376011836 substrate binding pocket [chemical binding]; other site 762376011837 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 762376011838 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762376011839 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 762376011840 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 762376011841 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 762376011842 putative NAD(P) binding site [chemical binding]; other site 762376011843 putative substrate binding site [chemical binding]; other site 762376011844 catalytic Zn binding site [ion binding]; other site 762376011845 structural Zn binding site [ion binding]; other site 762376011846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376011848 putative substrate translocation pore; other site 762376011849 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 762376011850 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 762376011851 DNA binding residues [nucleotide binding] 762376011852 putative dimer interface [polypeptide binding]; other site 762376011853 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 762376011854 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 762376011855 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376011856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376011857 DNA-binding site [nucleotide binding]; DNA binding site 762376011858 FCD domain; Region: FCD; pfam07729 762376011859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011861 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376011862 dimerization interface [polypeptide binding]; other site 762376011863 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 762376011864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376011865 methionine gamma-lyase; Validated; Region: PRK07049 762376011866 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762376011867 homodimer interface [polypeptide binding]; other site 762376011868 substrate-cofactor binding pocket; other site 762376011869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376011870 catalytic residue [active] 762376011871 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 762376011872 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376011873 putative DNA binding site [nucleotide binding]; other site 762376011874 putative Zn2+ binding site [ion binding]; other site 762376011875 AsnC family; Region: AsnC_trans_reg; pfam01037 762376011876 Response regulator receiver domain; Region: Response_reg; pfam00072 762376011877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376011878 active site 762376011879 phosphorylation site [posttranslational modification] 762376011880 intermolecular recognition site; other site 762376011881 dimerization interface [polypeptide binding]; other site 762376011882 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376011883 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376011884 metal binding site [ion binding]; metal-binding site 762376011885 active site 762376011886 I-site; other site 762376011887 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 762376011888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376011889 phosphorylation site [posttranslational modification] 762376011890 intermolecular recognition site; other site 762376011891 CheB methylesterase; Region: CheB_methylest; pfam01339 762376011892 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 762376011893 putative binding surface; other site 762376011894 active site 762376011895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376011896 ATP binding site [chemical binding]; other site 762376011897 Mg2+ binding site [ion binding]; other site 762376011898 G-X-G motif; other site 762376011899 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 762376011900 Response regulator receiver domain; Region: Response_reg; pfam00072 762376011901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376011902 active site 762376011903 phosphorylation site [posttranslational modification] 762376011904 intermolecular recognition site; other site 762376011905 dimerization interface [polypeptide binding]; other site 762376011906 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 762376011907 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 762376011908 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 762376011909 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 762376011910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762376011911 binding surface 762376011912 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 762376011913 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 762376011914 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 762376011915 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376011916 dimerization interface [polypeptide binding]; other site 762376011917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376011918 dimer interface [polypeptide binding]; other site 762376011919 putative CheW interface [polypeptide binding]; other site 762376011920 amidase; Provisional; Region: PRK07486 762376011921 Amidase; Region: Amidase; pfam01425 762376011922 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 762376011923 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 762376011924 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 762376011925 AAA domain; Region: AAA_33; pfam13671 762376011926 AAA domain; Region: AAA_17; pfam13207 762376011927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011929 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 762376011930 putative effector binding pocket; other site 762376011931 putative dimerization interface [polypeptide binding]; other site 762376011932 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 762376011933 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 762376011934 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762376011935 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 762376011936 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 762376011937 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376011938 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 762376011939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376011940 Coenzyme A binding pocket [chemical binding]; other site 762376011941 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762376011942 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376011943 Walker A/P-loop; other site 762376011944 ATP binding site [chemical binding]; other site 762376011945 Q-loop/lid; other site 762376011946 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376011947 ABC transporter signature motif; other site 762376011948 Walker B; other site 762376011949 D-loop; other site 762376011950 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376011951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376011952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011953 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376011954 dimerization interface [polypeptide binding]; other site 762376011955 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376011956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376011957 dimer interface [polypeptide binding]; other site 762376011958 conserved gate region; other site 762376011959 putative PBP binding loops; other site 762376011960 ABC-ATPase subunit interface; other site 762376011961 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376011962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376011963 dimer interface [polypeptide binding]; other site 762376011964 conserved gate region; other site 762376011965 putative PBP binding loops; other site 762376011966 ABC-ATPase subunit interface; other site 762376011967 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376011968 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376011969 Walker A/P-loop; other site 762376011970 ATP binding site [chemical binding]; other site 762376011971 Q-loop/lid; other site 762376011972 ABC transporter signature motif; other site 762376011973 Walker B; other site 762376011974 D-loop; other site 762376011975 H-loop/switch region; other site 762376011976 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376011977 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376011978 Walker A/P-loop; other site 762376011979 ATP binding site [chemical binding]; other site 762376011980 Q-loop/lid; other site 762376011981 ABC transporter signature motif; other site 762376011982 Walker B; other site 762376011983 D-loop; other site 762376011984 H-loop/switch region; other site 762376011985 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376011986 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 762376011987 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376011988 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376011989 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 762376011990 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 762376011991 putative active site [active] 762376011992 putative metal binding site [ion binding]; other site 762376011993 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 762376011994 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376011995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376011996 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376011997 putative effector binding pocket; other site 762376011998 dimerization interface [polypeptide binding]; other site 762376011999 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 762376012000 dimer interface [polypeptide binding]; other site 762376012001 FMN binding site [chemical binding]; other site 762376012002 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762376012003 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 762376012004 putative NAD(P) binding site [chemical binding]; other site 762376012005 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376012006 CoenzymeA binding site [chemical binding]; other site 762376012007 subunit interaction site [polypeptide binding]; other site 762376012008 PHB binding site; other site 762376012009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376012010 putative substrate translocation pore; other site 762376012011 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376012012 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 762376012013 dimer interface [polypeptide binding]; other site 762376012014 active site 762376012015 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 762376012016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376012017 NAD(P) binding site [chemical binding]; other site 762376012018 active site 762376012019 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376012020 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 762376012021 conserved cys residue [active] 762376012022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376012023 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 762376012024 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376012025 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 762376012026 active site 1 [active] 762376012027 dimer interface [polypeptide binding]; other site 762376012028 hexamer interface [polypeptide binding]; other site 762376012029 active site 2 [active] 762376012030 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762376012031 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 762376012032 aminoglycoside resistance protein; Provisional; Region: PRK13746 762376012033 active site 762376012034 NTP binding site [chemical binding]; other site 762376012035 metal binding triad [ion binding]; metal-binding site 762376012036 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 762376012037 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376012038 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376012039 N-terminal plug; other site 762376012040 ligand-binding site [chemical binding]; other site 762376012041 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376012042 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 762376012043 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 762376012044 DNA binding residues [nucleotide binding] 762376012045 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376012046 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376012047 N-terminal plug; other site 762376012048 ligand-binding site [chemical binding]; other site 762376012049 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376012050 FecR protein; Region: FecR; pfam04773 762376012051 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376012052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376012053 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376012054 DNA binding residues [nucleotide binding] 762376012055 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376012056 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 762376012057 homotrimer interaction site [polypeptide binding]; other site 762376012058 putative active site [active] 762376012059 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012061 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012062 dimerization interface [polypeptide binding]; other site 762376012063 Sulfatase; Region: Sulfatase; cl17466 762376012064 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376012065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376012066 GMP synthase; Reviewed; Region: guaA; PRK00074 762376012067 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 762376012068 AMP/PPi binding site [chemical binding]; other site 762376012069 candidate oxyanion hole; other site 762376012070 catalytic triad [active] 762376012071 potential glutamine specificity residues [chemical binding]; other site 762376012072 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 762376012073 ATP Binding subdomain [chemical binding]; other site 762376012074 Ligand Binding sites [chemical binding]; other site 762376012075 Dimerization subdomain; other site 762376012076 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 762376012077 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 762376012078 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 762376012079 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 762376012080 active site 762376012081 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 762376012082 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376012083 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 762376012084 conserved cys residue [active] 762376012085 Protein of unknown function, DUF393; Region: DUF393; pfam04134 762376012086 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 762376012087 active site clefts [active] 762376012088 zinc binding site [ion binding]; other site 762376012089 dimer interface [polypeptide binding]; other site 762376012090 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 762376012091 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376012092 ligand binding site [chemical binding]; other site 762376012093 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 762376012094 homotrimer interaction site [polypeptide binding]; other site 762376012095 putative active site [active] 762376012096 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376012097 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 762376012098 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 762376012099 active site 762376012100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012102 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376012103 putative dimerization interface [polypeptide binding]; other site 762376012104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012107 dimerization interface [polypeptide binding]; other site 762376012108 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 762376012109 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 762376012110 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376012111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376012112 dimer interface [polypeptide binding]; other site 762376012113 conserved gate region; other site 762376012114 putative PBP binding loops; other site 762376012115 ABC-ATPase subunit interface; other site 762376012116 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376012117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376012118 dimer interface [polypeptide binding]; other site 762376012119 conserved gate region; other site 762376012120 putative PBP binding loops; other site 762376012121 ABC-ATPase subunit interface; other site 762376012122 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376012123 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376012124 Walker A/P-loop; other site 762376012125 ATP binding site [chemical binding]; other site 762376012126 Q-loop/lid; other site 762376012127 ABC transporter signature motif; other site 762376012128 Walker B; other site 762376012129 D-loop; other site 762376012130 H-loop/switch region; other site 762376012131 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376012132 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376012133 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376012134 Walker A/P-loop; other site 762376012135 ATP binding site [chemical binding]; other site 762376012136 Q-loop/lid; other site 762376012137 ABC transporter signature motif; other site 762376012138 Walker B; other site 762376012139 D-loop; other site 762376012140 H-loop/switch region; other site 762376012141 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 762376012142 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376012143 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376012144 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 762376012145 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 762376012146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 762376012147 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376012148 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 762376012149 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376012150 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 762376012151 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376012152 Methyltransferase domain; Region: Methyltransf_32; pfam13679 762376012153 Methyltransferase domain; Region: Methyltransf_31; pfam13847 762376012154 Uncharacterized conserved protein [Function unknown]; Region: COG4933 762376012155 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 762376012156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376012157 Transposase; Region: HTH_Tnp_1; cl17663 762376012158 putative transposase OrfB; Reviewed; Region: PHA02517 762376012159 HTH-like domain; Region: HTH_21; pfam13276 762376012160 Integrase core domain; Region: rve; pfam00665 762376012161 Integrase core domain; Region: rve_3; pfam13683 762376012162 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376012163 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012165 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376012166 putative dimerization interface [polypeptide binding]; other site 762376012167 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 762376012168 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012169 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012170 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376012171 dimerization interface [polypeptide binding]; other site 762376012172 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376012173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376012174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012176 LysR substrate binding domain; Region: LysR_substrate; pfam03466 762376012177 dimerization interface [polypeptide binding]; other site 762376012178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376012179 D-galactonate transporter; Region: 2A0114; TIGR00893 762376012180 putative substrate translocation pore; other site 762376012181 classical (c) SDRs; Region: SDR_c; cd05233 762376012182 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 762376012183 NAD(P) binding site [chemical binding]; other site 762376012184 active site 762376012185 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 762376012186 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376012187 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762376012188 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 762376012189 Isochorismatase family; Region: Isochorismatase; pfam00857 762376012190 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 762376012191 catalytic triad [active] 762376012192 conserved cis-peptide bond; other site 762376012193 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 762376012194 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 762376012195 conserved cys residue [active] 762376012196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376012197 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376012198 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376012199 putative DNA binding site [nucleotide binding]; other site 762376012200 putative Zn2+ binding site [ion binding]; other site 762376012201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376012202 Coenzyme A binding pocket [chemical binding]; other site 762376012203 EamA-like transporter family; Region: EamA; pfam00892 762376012204 HD domain; Region: HD_3; pfam13023 762376012205 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 762376012206 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762376012207 tetramer interface [polypeptide binding]; other site 762376012208 catalytic Zn binding site [ion binding]; other site 762376012209 NADP binding site [chemical binding]; other site 762376012210 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 762376012211 Peptidase family M48; Region: Peptidase_M48; cl12018 762376012212 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376012213 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376012214 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376012215 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376012216 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376012217 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 762376012218 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 762376012219 Autotransporter beta-domain; Region: Autotransporter; smart00869 762376012220 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 762376012221 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 762376012222 phosphate binding site [ion binding]; other site 762376012223 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 762376012224 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376012225 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376012226 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 762376012227 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376012228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376012229 DNA-binding site [nucleotide binding]; DNA binding site 762376012230 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376012231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376012232 homodimer interface [polypeptide binding]; other site 762376012233 catalytic residue [active] 762376012234 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376012235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376012236 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 762376012237 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376012238 catalytic loop [active] 762376012239 iron binding site [ion binding]; other site 762376012240 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 762376012241 FAD binding pocket [chemical binding]; other site 762376012242 conserved FAD binding motif [chemical binding]; other site 762376012243 phosphate binding motif [ion binding]; other site 762376012244 beta-alpha-beta structure motif; other site 762376012245 NAD binding pocket [chemical binding]; other site 762376012246 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 762376012247 active site 762376012248 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 762376012249 B12 binding site [chemical binding]; other site 762376012250 Radical SAM superfamily; Region: Radical_SAM; pfam04055 762376012251 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376012252 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376012253 metal binding site [ion binding]; metal-binding site 762376012254 active site 762376012255 I-site; other site 762376012256 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 762376012257 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 762376012258 active site 762376012259 substrate binding site [chemical binding]; other site 762376012260 Mg2+ binding site [ion binding]; other site 762376012261 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 762376012262 dimer interface [polypeptide binding]; other site 762376012263 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 762376012264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762376012265 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376012266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376012267 metal binding site [ion binding]; metal-binding site 762376012268 active site 762376012269 I-site; other site 762376012270 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 762376012271 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 762376012272 nucleoside/Zn binding site; other site 762376012273 dimer interface [polypeptide binding]; other site 762376012274 catalytic motif [active] 762376012275 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 762376012276 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 762376012277 putative active site [active] 762376012278 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376012279 FAD binding domain; Region: FAD_binding_4; pfam01565 762376012280 Berberine and berberine like; Region: BBE; pfam08031 762376012281 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 762376012282 NodB motif; other site 762376012283 putative active site [active] 762376012284 putative catalytic site [active] 762376012285 putative Zn binding site [ion binding]; other site 762376012286 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 762376012287 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 762376012288 hypothetical protein; Provisional; Region: PRK06184 762376012289 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 762376012290 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 762376012291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012292 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376012293 dimerization interface [polypeptide binding]; other site 762376012294 Sulfatase; Region: Sulfatase; cl17466 762376012295 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376012296 Cupin domain; Region: Cupin_2; pfam07883 762376012297 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376012298 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 762376012299 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 762376012300 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376012301 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 762376012302 hypothetical protein; Provisional; Region: PRK07907 762376012303 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 762376012304 metal binding site [ion binding]; metal-binding site 762376012305 putative dimer interface [polypeptide binding]; other site 762376012306 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 762376012307 dimer interface [polypeptide binding]; other site 762376012308 ligand binding site [chemical binding]; other site 762376012309 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376012310 dimerization interface [polypeptide binding]; other site 762376012311 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 762376012312 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376012313 dimer interface [polypeptide binding]; other site 762376012314 putative CheW interface [polypeptide binding]; other site 762376012315 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376012316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376012317 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 762376012318 DNA binding residues [nucleotide binding] 762376012319 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376012320 FecR protein; Region: FecR; pfam04773 762376012321 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376012322 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376012323 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376012324 N-terminal plug; other site 762376012325 ligand-binding site [chemical binding]; other site 762376012326 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 762376012327 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 762376012328 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 762376012329 dimerization interface [polypeptide binding]; other site 762376012330 ATP binding site [chemical binding]; other site 762376012331 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 762376012332 dimerization interface [polypeptide binding]; other site 762376012333 ATP binding site [chemical binding]; other site 762376012334 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 762376012335 putative active site [active] 762376012336 catalytic triad [active] 762376012337 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 762376012338 DctM-like transporters; Region: DctM; pfam06808 762376012339 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 762376012340 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 762376012341 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 762376012342 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 762376012343 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 762376012344 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 762376012345 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 762376012346 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 762376012347 active site 762376012348 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 762376012349 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762376012350 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762376012351 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 762376012352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376012353 S-adenosylmethionine binding site [chemical binding]; other site 762376012354 choline dehydrogenase; Validated; Region: PRK02106 762376012355 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376012356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376012359 dimerization interface [polypeptide binding]; other site 762376012360 nitrite reductase subunit NirD; Provisional; Region: PRK14989 762376012361 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 762376012362 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 762376012363 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 762376012364 Bacterial transcriptional activator domain; Region: BTAD; smart01043 762376012365 Predicted integral membrane protein [Function unknown]; Region: COG5616 762376012366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762376012367 TPR motif; other site 762376012368 binding surface 762376012369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376012370 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 762376012371 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 762376012372 homodimer interface [polypeptide binding]; other site 762376012373 substrate-cofactor binding pocket; other site 762376012374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376012375 catalytic residue [active] 762376012376 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376012377 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376012378 Walker A/P-loop; other site 762376012379 ATP binding site [chemical binding]; other site 762376012380 Q-loop/lid; other site 762376012381 ABC transporter signature motif; other site 762376012382 Walker B; other site 762376012383 D-loop; other site 762376012384 H-loop/switch region; other site 762376012385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 762376012386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376012387 putative PBP binding loops; other site 762376012388 dimer interface [polypeptide binding]; other site 762376012389 ABC-ATPase subunit interface; other site 762376012390 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376012391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376012392 dimer interface [polypeptide binding]; other site 762376012393 conserved gate region; other site 762376012394 putative PBP binding loops; other site 762376012395 ABC-ATPase subunit interface; other site 762376012396 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 762376012397 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376012398 substrate binding pocket [chemical binding]; other site 762376012399 membrane-bound complex binding site; other site 762376012400 hinge residues; other site 762376012401 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012403 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376012404 dimerization interface [polypeptide binding]; other site 762376012405 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 762376012406 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762376012407 DNA binding site [nucleotide binding] 762376012408 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 762376012409 putative ligand binding site [chemical binding]; other site 762376012410 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 762376012411 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 762376012412 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 762376012413 DctM-like transporters; Region: DctM; pfam06808 762376012414 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 762376012415 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 762376012416 dimer interface [polypeptide binding]; other site 762376012417 substrate binding site [chemical binding]; other site 762376012418 metal binding site [ion binding]; metal-binding site 762376012419 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 762376012420 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 762376012421 dimer interface [polypeptide binding]; other site 762376012422 active site 762376012423 catalytic residue [active] 762376012424 metal binding site [ion binding]; metal-binding site 762376012425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 762376012426 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376012427 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376012428 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376012429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376012430 NAD(P) binding site [chemical binding]; other site 762376012431 active site 762376012432 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 762376012433 active site 762376012434 catalytic site [active] 762376012435 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376012436 active site 762376012437 catalytic site [active] 762376012438 lipid-transfer protein; Provisional; Region: PRK08256 762376012439 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376012440 active site 762376012441 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 762376012442 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 762376012443 FMN binding site [chemical binding]; other site 762376012444 substrate binding site [chemical binding]; other site 762376012445 putative catalytic residue [active] 762376012446 AAA ATPase domain; Region: AAA_16; pfam13191 762376012447 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 762376012448 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376012449 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376012450 DNA binding residues [nucleotide binding] 762376012451 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376012452 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376012453 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376012454 active site 762376012455 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376012456 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376012457 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376012458 active site 762376012459 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376012460 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376012461 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376012462 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376012463 substrate binding site [chemical binding]; other site 762376012464 oxyanion hole (OAH) forming residues; other site 762376012465 trimer interface [polypeptide binding]; other site 762376012466 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376012467 enoyl-CoA hydratase; Provisional; Region: PRK06688 762376012468 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376012469 substrate binding site [chemical binding]; other site 762376012470 oxyanion hole (OAH) forming residues; other site 762376012471 trimer interface [polypeptide binding]; other site 762376012472 hypothetical protein; Provisional; Region: PRK08204 762376012473 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376012474 active site 762376012475 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376012476 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 762376012477 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 762376012478 trimer interface [polypeptide binding]; other site 762376012479 eyelet of channel; other site 762376012480 hypothetical protein; Provisional; Region: PRK08204 762376012481 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376012482 active site 762376012483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012485 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376012486 putative effector binding pocket; other site 762376012487 dimerization interface [polypeptide binding]; other site 762376012488 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 762376012489 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376012490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376012491 DNA-binding site [nucleotide binding]; DNA binding site 762376012492 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376012493 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 762376012494 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 762376012495 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 762376012496 active site 762376012497 NAD binding site [chemical binding]; other site 762376012498 metal binding site [ion binding]; metal-binding site 762376012499 succinic semialdehyde dehydrogenase; Region: PLN02278 762376012500 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762376012501 tetramerization interface [polypeptide binding]; other site 762376012502 NAD(P) binding site [chemical binding]; other site 762376012503 catalytic residues [active] 762376012504 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 762376012505 tartrate dehydrogenase; Region: TTC; TIGR02089 762376012506 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376012507 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 762376012508 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 762376012509 Competence protein; Region: Competence; pfam03772 762376012510 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762376012511 short chain dehydrogenase; Provisional; Region: PRK07791 762376012512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376012513 NAD(P) binding site [chemical binding]; other site 762376012514 active site 762376012515 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 762376012516 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376012517 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 762376012518 acyl-activating enzyme (AAE) consensus motif; other site 762376012519 putative AMP binding site [chemical binding]; other site 762376012520 putative active site [active] 762376012521 acyl-activating enzyme (AAE) consensus motif; other site 762376012522 putative CoA binding site [chemical binding]; other site 762376012523 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376012524 active site 2 [active] 762376012525 active site 1 [active] 762376012526 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376012527 active site 762376012528 catalytic site [active] 762376012529 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376012530 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376012531 thiolase; Provisional; Region: PRK06158 762376012532 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376012533 active site 762376012534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376012535 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 762376012536 benzoate transporter; Region: benE; TIGR00843 762376012537 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376012538 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762376012539 active site 762376012540 metal binding site [ion binding]; metal-binding site 762376012541 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 762376012542 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376012543 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 762376012544 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 762376012545 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376012546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376012547 dimer interface [polypeptide binding]; other site 762376012548 conserved gate region; other site 762376012549 ABC-ATPase subunit interface; other site 762376012550 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376012551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376012552 dimer interface [polypeptide binding]; other site 762376012553 putative PBP binding loops; other site 762376012554 ABC-ATPase subunit interface; other site 762376012555 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376012556 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762376012557 Walker A/P-loop; other site 762376012558 ATP binding site [chemical binding]; other site 762376012559 Q-loop/lid; other site 762376012560 ABC transporter signature motif; other site 762376012561 Walker B; other site 762376012562 D-loop; other site 762376012563 H-loop/switch region; other site 762376012564 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376012565 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 762376012566 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 762376012567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376012568 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 762376012569 [2Fe-2S] cluster binding site [ion binding]; other site 762376012570 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376012571 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 762376012572 iron-sulfur cluster [ion binding]; other site 762376012573 [2Fe-2S] cluster binding site [ion binding]; other site 762376012574 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 762376012575 putative alpha subunit interface [polypeptide binding]; other site 762376012576 putative active site [active] 762376012577 putative substrate binding site [chemical binding]; other site 762376012578 Fe binding site [ion binding]; other site 762376012579 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 762376012580 inter-subunit interface; other site 762376012581 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 762376012582 Cupin domain; Region: Cupin_2; cl17218 762376012583 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 762376012584 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 762376012585 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 762376012586 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376012587 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376012588 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376012589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376012590 DNA-binding site [nucleotide binding]; DNA binding site 762376012591 FCD domain; Region: FCD; pfam07729 762376012592 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 762376012593 substrate binding site [chemical binding]; other site 762376012594 multimerization interface [polypeptide binding]; other site 762376012595 ATP binding site [chemical binding]; other site 762376012596 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 762376012597 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376012598 N-terminal plug; other site 762376012599 ligand-binding site [chemical binding]; other site 762376012600 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 762376012601 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 762376012602 active site 762376012603 metal binding site [ion binding]; metal-binding site 762376012604 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762376012605 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 762376012606 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762376012607 Walker A/P-loop; other site 762376012608 ATP binding site [chemical binding]; other site 762376012609 Q-loop/lid; other site 762376012610 ABC transporter signature motif; other site 762376012611 Walker B; other site 762376012612 D-loop; other site 762376012613 H-loop/switch region; other site 762376012614 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762376012615 ABC-ATPase subunit interface; other site 762376012616 dimer interface [polypeptide binding]; other site 762376012617 putative PBP binding regions; other site 762376012618 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 762376012619 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762376012620 ABC-ATPase subunit interface; other site 762376012621 dimer interface [polypeptide binding]; other site 762376012622 putative PBP binding regions; other site 762376012623 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 762376012624 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 762376012625 putative ligand binding residues [chemical binding]; other site 762376012626 enterobactin receptor protein; Provisional; Region: PRK13483 762376012627 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376012628 N-terminal plug; other site 762376012629 ligand-binding site [chemical binding]; other site 762376012630 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376012631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376012632 active site 762376012633 phosphorylation site [posttranslational modification] 762376012634 intermolecular recognition site; other site 762376012635 dimerization interface [polypeptide binding]; other site 762376012636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376012637 DNA binding site [nucleotide binding] 762376012638 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376012639 dimerization interface [polypeptide binding]; other site 762376012640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376012641 dimer interface [polypeptide binding]; other site 762376012642 phosphorylation site [posttranslational modification] 762376012643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376012644 ATP binding site [chemical binding]; other site 762376012645 Mg2+ binding site [ion binding]; other site 762376012646 G-X-G motif; other site 762376012647 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 762376012648 active site 762376012649 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 762376012650 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762376012651 Walker A/P-loop; other site 762376012652 ATP binding site [chemical binding]; other site 762376012653 Q-loop/lid; other site 762376012654 ABC transporter signature motif; other site 762376012655 Walker B; other site 762376012656 D-loop; other site 762376012657 H-loop/switch region; other site 762376012658 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 762376012659 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762376012660 FtsX-like permease family; Region: FtsX; pfam02687 762376012661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 762376012662 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 762376012663 DHH family; Region: DHH; pfam01368 762376012664 DHHA1 domain; Region: DHHA1; pfam02272 762376012665 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 762376012666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376012667 putative substrate translocation pore; other site 762376012668 peptide chain release factor 2; Provisional; Region: PRK08787 762376012669 This domain is found in peptide chain release factors; Region: PCRF; smart00937 762376012670 RF-1 domain; Region: RF-1; pfam00472 762376012671 short chain dehydrogenase; Provisional; Region: PRK07023 762376012672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376012673 NAD(P) binding site [chemical binding]; other site 762376012674 active site 762376012675 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 762376012676 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 762376012677 dimer interface [polypeptide binding]; other site 762376012678 putative anticodon binding site; other site 762376012679 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 762376012680 motif 1; other site 762376012681 active site 762376012682 motif 2; other site 762376012683 motif 3; other site 762376012684 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376012685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376012686 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376012687 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 762376012688 dimer interface [polypeptide binding]; other site 762376012689 active site 762376012690 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 762376012691 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376012692 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 762376012693 acyl-activating enzyme (AAE) consensus motif; other site 762376012694 putative AMP binding site [chemical binding]; other site 762376012695 putative active site [active] 762376012696 putative CoA binding site [chemical binding]; other site 762376012697 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376012698 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376012699 Walker A/P-loop; other site 762376012700 ATP binding site [chemical binding]; other site 762376012701 Q-loop/lid; other site 762376012702 ABC transporter signature motif; other site 762376012703 Walker B; other site 762376012704 D-loop; other site 762376012705 H-loop/switch region; other site 762376012706 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 762376012707 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376012708 putative ligand binding site [chemical binding]; other site 762376012709 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376012710 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376012711 TM-ABC transporter signature motif; other site 762376012712 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376012713 TM-ABC transporter signature motif; other site 762376012714 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376012715 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376012716 Walker A/P-loop; other site 762376012717 ATP binding site [chemical binding]; other site 762376012718 Q-loop/lid; other site 762376012719 ABC transporter signature motif; other site 762376012720 Walker B; other site 762376012721 D-loop; other site 762376012722 H-loop/switch region; other site 762376012723 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376012724 enoyl-CoA hydratase; Provisional; Region: PRK06688 762376012725 substrate binding site [chemical binding]; other site 762376012726 oxyanion hole (OAH) forming residues; other site 762376012727 trimer interface [polypeptide binding]; other site 762376012728 enoyl-CoA hydratase; Provisional; Region: PRK06688 762376012729 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376012730 substrate binding site [chemical binding]; other site 762376012731 oxyanion hole (OAH) forming residues; other site 762376012732 trimer interface [polypeptide binding]; other site 762376012733 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376012734 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376012735 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376012736 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 762376012737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012738 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376012739 putative dimerization interface [polypeptide binding]; other site 762376012740 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 762376012741 active site 762376012742 dimer interfaces [polypeptide binding]; other site 762376012743 catalytic residues [active] 762376012744 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 762376012745 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 762376012746 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376012747 catalytic loop [active] 762376012748 iron binding site [ion binding]; other site 762376012749 chaperone protein HscA; Provisional; Region: hscA; PRK05183 762376012750 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 762376012751 nucleotide binding site [chemical binding]; other site 762376012752 co-chaperone HscB; Provisional; Region: hscB; PRK03578 762376012753 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 762376012754 HSP70 interaction site [polypeptide binding]; other site 762376012755 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 762376012756 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 762376012757 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 762376012758 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 762376012759 trimerization site [polypeptide binding]; other site 762376012760 active site 762376012761 cysteine desulfurase; Provisional; Region: PRK14012 762376012762 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 762376012763 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376012764 catalytic residue [active] 762376012765 Predicted transcriptional regulator [Transcription]; Region: COG1959 762376012766 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 762376012767 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 762376012768 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762376012769 active site 762376012770 excinuclease ABC subunit B; Provisional; Region: PRK05298 762376012771 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376012772 ATP binding site [chemical binding]; other site 762376012773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376012774 nucleotide binding region [chemical binding]; other site 762376012775 ATP-binding site [chemical binding]; other site 762376012776 Ultra-violet resistance protein B; Region: UvrB; pfam12344 762376012777 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 762376012778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376012779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376012780 homodimer interface [polypeptide binding]; other site 762376012781 catalytic residue [active] 762376012782 LexA repressor; Validated; Region: PRK00215 762376012783 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 762376012784 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 762376012785 Catalytic site [active] 762376012786 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 762376012787 Found in ATP-dependent protease La (LON); Region: LON; smart00464 762376012788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376012789 Walker A motif; other site 762376012790 ATP binding site [chemical binding]; other site 762376012791 Walker B motif; other site 762376012792 arginine finger; other site 762376012793 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 762376012794 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 762376012795 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 762376012796 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 762376012797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376012798 Walker A motif; other site 762376012799 ATP binding site [chemical binding]; other site 762376012800 Walker B motif; other site 762376012801 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 762376012802 Clp protease; Region: CLP_protease; pfam00574 762376012803 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 762376012804 oligomer interface [polypeptide binding]; other site 762376012805 active site residues [active] 762376012806 trigger factor; Provisional; Region: tig; PRK01490 762376012807 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 762376012808 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 762376012809 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 762376012810 hypothetical protein; Provisional; Region: PRK05208 762376012811 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762376012812 DNA-binding site [nucleotide binding]; DNA binding site 762376012813 RNA-binding motif; other site 762376012814 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 762376012815 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762376012816 DNA-binding site [nucleotide binding]; DNA binding site 762376012817 RNA-binding motif; other site 762376012818 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 762376012819 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376012820 homotrimer interaction site [polypeptide binding]; other site 762376012821 putative active site [active] 762376012822 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 762376012823 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 762376012824 active site 762376012825 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376012826 dimer interface [polypeptide binding]; other site 762376012827 substrate binding site [chemical binding]; other site 762376012828 catalytic residue [active] 762376012829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012831 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 762376012832 putative effector binding pocket; other site 762376012833 putative dimerization interface [polypeptide binding]; other site 762376012834 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376012835 homotrimer interaction site [polypeptide binding]; other site 762376012836 putative active site [active] 762376012837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376012838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376012839 putative substrate translocation pore; other site 762376012840 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 762376012841 mce related protein; Region: MCE; pfam02470 762376012842 mce related protein; Region: MCE; pfam02470 762376012843 mce related protein; Region: MCE; pfam02470 762376012844 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762376012845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376012846 Coenzyme A binding pocket [chemical binding]; other site 762376012847 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 762376012848 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 762376012849 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 762376012850 MgtC family; Region: MgtC; pfam02308 762376012851 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 762376012852 amphipathic channel; other site 762376012853 Asn-Pro-Ala signature motifs; other site 762376012854 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376012855 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 762376012856 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 762376012857 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 762376012858 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 762376012859 dinuclear metal binding motif [ion binding]; other site 762376012860 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 762376012861 Phage holin family 2; Region: Phage_holin_2; pfam04550 762376012862 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 762376012863 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 762376012864 Phage-related minor tail protein [Function unknown]; Region: COG5281 762376012865 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 762376012866 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 762376012867 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 762376012868 Phage tail protein; Region: Phage_tail_3; pfam08813 762376012869 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 762376012870 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 762376012871 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 762376012872 oligomerization interface [polypeptide binding]; other site 762376012873 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 762376012874 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 762376012875 Phage capsid family; Region: Phage_capsid; pfam05065 762376012876 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 762376012877 oligomer interface [polypeptide binding]; other site 762376012878 active site residues [active] 762376012879 Phage portal protein; Region: Phage_portal; pfam04860 762376012880 Phage-related protein [Function unknown]; Region: COG4695; cl01923 762376012881 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 762376012882 Terminase small subunit; Region: Terminase_2; cl01513 762376012883 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 762376012884 active site 762376012885 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 762376012886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 762376012887 Protein of unknown function (DUF1376); Region: DUF1376; pfam07120 762376012888 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 762376012889 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 762376012890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 762376012891 Predicted transcriptional regulator [Transcription]; Region: COG2932 762376012892 non-specific DNA binding site [nucleotide binding]; other site 762376012893 salt bridge; other site 762376012894 sequence-specific DNA binding site [nucleotide binding]; other site 762376012895 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 762376012896 Catalytic site [active] 762376012897 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762376012898 DNA-binding site [nucleotide binding]; DNA binding site 762376012899 RNA-binding motif; other site 762376012900 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 762376012901 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 762376012902 ASCH domain; Region: ASCH; pfam04266 762376012903 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376012904 active site 762376012905 DNA binding site [nucleotide binding] 762376012906 Int/Topo IB signature motif; other site 762376012907 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 762376012908 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376012909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376012910 homodimer interface [polypeptide binding]; other site 762376012911 catalytic residue [active] 762376012912 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 762376012913 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 762376012914 trimer interface [polypeptide binding]; other site 762376012915 active site 762376012916 substrate binding site [chemical binding]; other site 762376012917 CoA binding site [chemical binding]; other site 762376012918 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 762376012919 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 762376012920 metal binding site [ion binding]; metal-binding site 762376012921 dimer interface [polypeptide binding]; other site 762376012922 HemK family putative methylases; Region: hemK_fam; TIGR00536 762376012923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376012924 S-adenosylmethionine binding site [chemical binding]; other site 762376012925 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 762376012926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376012927 Walker A/P-loop; other site 762376012928 ATP binding site [chemical binding]; other site 762376012929 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376012930 ABC transporter; Region: ABC_tran_2; pfam12848 762376012931 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762376012932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376012933 RNA polymerase sigma factor; Reviewed; Region: PRK12527 762376012934 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 762376012935 DNA binding residues [nucleotide binding] 762376012936 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376012937 FecR protein; Region: FecR; pfam04773 762376012938 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376012939 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762376012940 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762376012941 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 762376012942 Chorismate mutase type II; Region: CM_2; cl00693 762376012943 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 762376012944 Part of AAA domain; Region: AAA_19; pfam13245 762376012945 Family description; Region: UvrD_C_2; pfam13538 762376012946 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 762376012947 Fatty acid desaturase; Region: FA_desaturase; pfam00487 762376012948 Di-iron ligands [ion binding]; other site 762376012949 Transposase; Region: DDE_Tnp_ISL3; pfam01610 762376012950 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 762376012951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376012952 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 762376012953 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 762376012954 active site 762376012955 substrate binding site [chemical binding]; other site 762376012956 cosubstrate binding site; other site 762376012957 catalytic site [active] 762376012958 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 762376012959 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 762376012960 active site 762376012961 Riboflavin kinase; Region: Flavokinase; smart00904 762376012962 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 762376012963 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376012964 active site 762376012965 HIGH motif; other site 762376012966 nucleotide binding site [chemical binding]; other site 762376012967 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 762376012968 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 762376012969 active site 762376012970 KMSKS motif; other site 762376012971 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 762376012972 tRNA binding surface [nucleotide binding]; other site 762376012973 anticodon binding site; other site 762376012974 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 762376012975 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 762376012976 lipoprotein signal peptidase; Provisional; Region: PRK14787 762376012977 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 762376012978 Flavoprotein; Region: Flavoprotein; pfam02441 762376012979 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 762376012980 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 762376012981 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376012982 AroM protein; Region: AroM; cl17601 762376012983 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 762376012984 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 762376012985 active site pocket [active] 762376012986 oxyanion hole [active] 762376012987 catalytic triad [active] 762376012988 active site nucleophile [active] 762376012989 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376012990 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376012991 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376012992 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376012993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376012994 LysR substrate binding domain; Region: LysR_substrate; pfam03466 762376012995 dimerization interface [polypeptide binding]; other site 762376012996 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376012997 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376012998 Amidase; Region: Amidase; cl11426 762376012999 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 762376013000 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 762376013001 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762376013002 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 762376013003 dUTPase; Region: dUTPase_2; pfam08761 762376013004 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 762376013005 active site 762376013006 homodimer interface [polypeptide binding]; other site 762376013007 metal binding site [ion binding]; metal-binding site 762376013008 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 762376013009 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 762376013010 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 762376013011 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013013 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376013014 putative effector binding pocket; other site 762376013015 dimerization interface [polypeptide binding]; other site 762376013016 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013017 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 762376013018 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 762376013019 active site 762376013020 dimer interface [polypeptide binding]; other site 762376013021 metal binding site [ion binding]; metal-binding site 762376013022 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762376013023 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 762376013024 active site 762376013025 FMN binding site [chemical binding]; other site 762376013026 substrate binding site [chemical binding]; other site 762376013027 homotetramer interface [polypeptide binding]; other site 762376013028 catalytic residue [active] 762376013029 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376013030 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376013031 Walker A/P-loop; other site 762376013032 ATP binding site [chemical binding]; other site 762376013033 Q-loop/lid; other site 762376013034 ABC transporter signature motif; other site 762376013035 Walker B; other site 762376013036 D-loop; other site 762376013037 H-loop/switch region; other site 762376013038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376013039 dimer interface [polypeptide binding]; other site 762376013040 conserved gate region; other site 762376013041 putative PBP binding loops; other site 762376013042 ABC-ATPase subunit interface; other site 762376013043 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376013044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376013045 dimer interface [polypeptide binding]; other site 762376013046 conserved gate region; other site 762376013047 putative PBP binding loops; other site 762376013048 ABC-ATPase subunit interface; other site 762376013049 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376013050 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376013051 substrate binding pocket [chemical binding]; other site 762376013052 membrane-bound complex binding site; other site 762376013053 hinge residues; other site 762376013054 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376013055 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376013056 putative ligand binding site [chemical binding]; other site 762376013057 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 762376013058 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 762376013059 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 762376013060 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013062 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376013063 putative effector binding pocket; other site 762376013064 dimerization interface [polypeptide binding]; other site 762376013065 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 762376013066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013068 dimerization interface [polypeptide binding]; other site 762376013069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376013070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376013071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376013072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376013073 putative substrate translocation pore; other site 762376013074 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 762376013075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376013076 DNA-binding site [nucleotide binding]; DNA binding site 762376013077 FCD domain; Region: FCD; pfam07729 762376013078 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013079 enoyl-CoA hydratase; Provisional; Region: PRK06127 762376013080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376013081 substrate binding site [chemical binding]; other site 762376013082 oxyanion hole (OAH) forming residues; other site 762376013083 trimer interface [polypeptide binding]; other site 762376013084 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376013085 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376013086 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376013087 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376013088 Walker A/P-loop; other site 762376013089 ATP binding site [chemical binding]; other site 762376013090 Q-loop/lid; other site 762376013091 ABC transporter signature motif; other site 762376013092 Walker B; other site 762376013093 D-loop; other site 762376013094 H-loop/switch region; other site 762376013095 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376013096 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376013097 Walker A/P-loop; other site 762376013098 ATP binding site [chemical binding]; other site 762376013099 Q-loop/lid; other site 762376013100 ABC transporter signature motif; other site 762376013101 Walker B; other site 762376013102 D-loop; other site 762376013103 H-loop/switch region; other site 762376013104 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376013105 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376013106 TM-ABC transporter signature motif; other site 762376013107 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376013108 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376013109 TM-ABC transporter signature motif; other site 762376013110 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376013111 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 762376013112 dimerization interface [polypeptide binding]; other site 762376013113 ligand binding site [chemical binding]; other site 762376013114 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 762376013115 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 762376013116 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 762376013117 Glutamate binding site [chemical binding]; other site 762376013118 NAD binding site [chemical binding]; other site 762376013119 catalytic residues [active] 762376013120 Protein of unknown function (DUF330); Region: DUF330; pfam03886 762376013121 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 762376013122 mce related protein; Region: MCE; pfam02470 762376013123 mce related protein; Region: MCE; pfam02470 762376013124 mce related protein; Region: MCE; pfam02470 762376013125 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 762376013126 Paraquat-inducible protein A; Region: PqiA; pfam04403 762376013127 Paraquat-inducible protein A; Region: PqiA; pfam04403 762376013128 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 762376013129 Clp amino terminal domain; Region: Clp_N; pfam02861 762376013130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376013131 Walker A motif; other site 762376013132 ATP binding site [chemical binding]; other site 762376013133 Walker B motif; other site 762376013134 arginine finger; other site 762376013135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376013136 Walker A motif; other site 762376013137 ATP binding site [chemical binding]; other site 762376013138 Walker B motif; other site 762376013139 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 762376013140 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 762376013141 Transglycosylase; Region: Transgly; pfam00912 762376013142 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 762376013143 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 762376013144 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 762376013145 MG2 domain; Region: A2M_N; pfam01835 762376013146 Alpha-2-macroglobulin family; Region: A2M; pfam00207 762376013147 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 762376013148 surface patch; other site 762376013149 thioester region; other site 762376013150 specificity defining residues; other site 762376013151 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 762376013152 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762376013153 DNA-binding site [nucleotide binding]; DNA binding site 762376013154 RNA-binding motif; other site 762376013155 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 762376013156 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 762376013157 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376013158 dimer interface [polypeptide binding]; other site 762376013159 active site 762376013160 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 762376013161 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 762376013162 putative ion selectivity filter; other site 762376013163 putative pore gating glutamate residue; other site 762376013164 putative H+/Cl- coupling transport residue; other site 762376013165 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 762376013166 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 762376013167 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376013168 dimerization interface [polypeptide binding]; other site 762376013169 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376013170 dimer interface [polypeptide binding]; other site 762376013171 putative CheW interface [polypeptide binding]; other site 762376013172 superoxide dismutase; Provisional; Region: PRK10543 762376013173 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 762376013174 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 762376013175 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 762376013176 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 762376013177 generic binding surface II; other site 762376013178 generic binding surface I; other site 762376013179 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 762376013180 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 762376013181 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 762376013182 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 762376013183 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 762376013184 Uncharacterized conserved protein [Function unknown]; Region: COG2835 762376013185 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 762376013186 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 762376013187 Ligand binding site; other site 762376013188 oligomer interface; other site 762376013189 adenylate kinase; Reviewed; Region: adk; PRK00279 762376013190 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 762376013191 AMP-binding site [chemical binding]; other site 762376013192 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 762376013193 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 762376013194 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 762376013195 NAD binding site [chemical binding]; other site 762376013196 homodimer interface [polypeptide binding]; other site 762376013197 homotetramer interface [polypeptide binding]; other site 762376013198 active site 762376013199 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 762376013200 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 762376013201 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376013202 FecR protein; Region: FecR; pfam04773 762376013203 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 762376013204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013206 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376013207 putative effector binding pocket; other site 762376013208 dimerization interface [polypeptide binding]; other site 762376013209 choline dehydrogenase; Validated; Region: PRK02106 762376013210 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376013211 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376013212 Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Region: ALDH_PsfA-ACA09737; cd07120 762376013213 NAD(P) binding site [chemical binding]; other site 762376013214 catalytic residues [active] 762376013215 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 762376013216 heme binding pocket [chemical binding]; other site 762376013217 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376013218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013220 dimerization interface [polypeptide binding]; other site 762376013221 diaminopimelate decarboxylase; Provisional; Region: PRK11165 762376013222 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 762376013223 active site 762376013224 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376013225 substrate binding site [chemical binding]; other site 762376013226 catalytic residues [active] 762376013227 dimer interface [polypeptide binding]; other site 762376013228 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 762376013229 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013230 dihydroxy-acid dehydratase; Validated; Region: PRK06131 762376013231 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 762376013232 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376013233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376013234 DNA-binding site [nucleotide binding]; DNA binding site 762376013235 FCD domain; Region: FCD; pfam07729 762376013236 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376013237 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762376013238 inhibitor site; inhibition site 762376013239 active site 762376013240 dimer interface [polypeptide binding]; other site 762376013241 catalytic residue [active] 762376013242 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013243 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013244 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762376013245 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 762376013246 putative ligand binding site [chemical binding]; other site 762376013247 NAD binding site [chemical binding]; other site 762376013248 catalytic site [active] 762376013249 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376013250 DNA repair protein RadA; Provisional; Region: PRK11823 762376013251 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 762376013252 Walker A motif/ATP binding site; other site 762376013253 ATP binding site [chemical binding]; other site 762376013254 Walker B motif; other site 762376013255 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 762376013256 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 762376013257 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376013258 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 762376013259 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 762376013260 putative active site [active] 762376013261 putative metal binding site [ion binding]; other site 762376013262 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 762376013263 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 762376013264 NAD binding site [chemical binding]; other site 762376013265 catalytic residues [active] 762376013266 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 762376013267 putative substrate binding pocket [chemical binding]; other site 762376013268 trimer interface [polypeptide binding]; other site 762376013269 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376013270 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376013271 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 762376013272 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376013273 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376013274 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 762376013275 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376013276 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762376013277 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013278 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 762376013279 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376013280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013282 dimerization interface [polypeptide binding]; other site 762376013283 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 762376013284 active site 1 [active] 762376013285 dimer interface [polypeptide binding]; other site 762376013286 hexamer interface [polypeptide binding]; other site 762376013287 active site 2 [active] 762376013288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013290 dimerization interface [polypeptide binding]; other site 762376013291 short chain dehydrogenase; Provisional; Region: PRK07577 762376013292 classical (c) SDRs; Region: SDR_c; cd05233 762376013293 NAD(P) binding site [chemical binding]; other site 762376013294 active site 762376013295 alanine racemase; Reviewed; Region: alr; PRK00053 762376013296 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 762376013297 active site 762376013298 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376013299 substrate binding site [chemical binding]; other site 762376013300 catalytic residues [active] 762376013301 dimer interface [polypeptide binding]; other site 762376013302 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 762376013303 active site lid residues [active] 762376013304 substrate binding pocket [chemical binding]; other site 762376013305 catalytic residues [active] 762376013306 substrate-Mg2+ binding site; other site 762376013307 aspartate-rich region 1; other site 762376013308 aspartate-rich region 2; other site 762376013309 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 762376013310 active site lid residues [active] 762376013311 substrate binding pocket [chemical binding]; other site 762376013312 catalytic residues [active] 762376013313 substrate-Mg2+ binding site; other site 762376013314 aspartate-rich region 1; other site 762376013315 aspartate-rich region 2; other site 762376013316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762376013317 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 762376013318 chromosome condensation membrane protein; Provisional; Region: PRK14196 762376013319 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 762376013320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 762376013321 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 762376013322 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 762376013323 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 762376013324 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 762376013325 ApbE family; Region: ApbE; pfam02424 762376013326 Flavodoxin; Region: Flavodoxin_1; pfam00258 762376013327 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 762376013328 FAD binding pocket [chemical binding]; other site 762376013329 FAD binding motif [chemical binding]; other site 762376013330 catalytic residues [active] 762376013331 NAD binding pocket [chemical binding]; other site 762376013332 phosphate binding motif [ion binding]; other site 762376013333 beta-alpha-beta structure motif; other site 762376013334 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013335 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 762376013336 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 762376013337 active site 762376013338 putative substrate binding pocket [chemical binding]; other site 762376013339 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376013340 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013341 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013342 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013343 dimerization interface [polypeptide binding]; other site 762376013344 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 762376013345 putative hydrophobic ligand binding site [chemical binding]; other site 762376013346 protein interface [polypeptide binding]; other site 762376013347 gate; other site 762376013348 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 762376013349 hypothetical protein; Provisional; Region: PRK02399 762376013350 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 762376013351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376013352 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 762376013353 DNA-binding interface [nucleotide binding]; DNA binding site 762376013354 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376013355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376013356 DNA-binding site [nucleotide binding]; DNA binding site 762376013357 FCD domain; Region: FCD; pfam07729 762376013358 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762376013359 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 762376013360 NAD binding site [chemical binding]; other site 762376013361 hypothetical protein; Validated; Region: PRK06201 762376013362 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 762376013363 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013364 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376013365 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 762376013366 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376013367 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376013368 Sulfatase; Region: Sulfatase; cl17466 762376013369 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376013370 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013371 3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399 762376013372 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376013373 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 762376013374 NAD(P) binding site [chemical binding]; other site 762376013375 catalytic residues [active] 762376013376 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 762376013377 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 762376013378 dimer interface [polypeptide binding]; other site 762376013379 active site 762376013380 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 762376013381 iron-sulfur cluster [ion binding]; other site 762376013382 [2Fe-2S] cluster binding site [ion binding]; other site 762376013383 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 762376013384 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376013385 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 762376013386 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 762376013387 Clp amino terminal domain; Region: Clp_N; pfam02861 762376013388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376013389 Walker A motif; other site 762376013390 ATP binding site [chemical binding]; other site 762376013391 Walker B motif; other site 762376013392 arginine finger; other site 762376013393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376013394 Walker A motif; other site 762376013395 ATP binding site [chemical binding]; other site 762376013396 Walker B motif; other site 762376013397 arginine finger; other site 762376013398 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762376013399 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 762376013400 putative active site pocket [active] 762376013401 dimerization interface [polypeptide binding]; other site 762376013402 putative catalytic residue [active] 762376013403 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 762376013404 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376013405 ligand binding site [chemical binding]; other site 762376013406 flexible hinge region; other site 762376013407 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 762376013408 putative switch regulator; other site 762376013409 non-specific DNA interactions [nucleotide binding]; other site 762376013410 DNA binding site [nucleotide binding] 762376013411 sequence specific DNA binding site [nucleotide binding]; other site 762376013412 putative cAMP binding site [chemical binding]; other site 762376013413 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 762376013414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376013415 putative substrate translocation pore; other site 762376013416 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376013417 dimerization interface [polypeptide binding]; other site 762376013418 putative DNA binding site [nucleotide binding]; other site 762376013419 putative Zn2+ binding site [ion binding]; other site 762376013420 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 762376013421 putative hydrophobic ligand binding site [chemical binding]; other site 762376013422 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 762376013423 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376013424 catalytic loop [active] 762376013425 iron binding site [ion binding]; other site 762376013426 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 762376013427 dimer interface [polypeptide binding]; other site 762376013428 ADP-ribose binding site [chemical binding]; other site 762376013429 active site 762376013430 nudix motif; other site 762376013431 metal binding site [ion binding]; metal-binding site 762376013432 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 762376013433 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762376013434 putative NAD(P) binding site [chemical binding]; other site 762376013435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013437 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013438 dimerization interface [polypeptide binding]; other site 762376013439 putative chaperone; Provisional; Region: PRK11678 762376013440 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 762376013441 nucleotide binding site [chemical binding]; other site 762376013442 putative NEF/HSP70 interaction site [polypeptide binding]; other site 762376013443 SBD interface [polypeptide binding]; other site 762376013444 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 762376013445 muropeptide transporter; Validated; Region: ampG; cl17669 762376013446 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 762376013447 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376013448 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376013449 N-terminal plug; other site 762376013450 ligand-binding site [chemical binding]; other site 762376013451 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376013452 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 762376013453 Isochorismatase family; Region: Isochorismatase; pfam00857 762376013454 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 762376013455 catalytic triad [active] 762376013456 conserved cis-peptide bond; other site 762376013457 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 762376013458 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376013459 SnoaL-like domain; Region: SnoaL_2; pfam12680 762376013460 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762376013461 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762376013462 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376013463 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 762376013464 putative C-terminal domain interface [polypeptide binding]; other site 762376013465 putative GSH binding site (G-site) [chemical binding]; other site 762376013466 putative dimer interface [polypeptide binding]; other site 762376013467 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 762376013468 putative N-terminal domain interface [polypeptide binding]; other site 762376013469 putative dimer interface [polypeptide binding]; other site 762376013470 putative substrate binding pocket (H-site) [chemical binding]; other site 762376013471 OsmC-like protein; Region: OsmC; cl00767 762376013472 NlpE N-terminal domain; Region: NlpE; pfam04170 762376013473 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 762376013474 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376013475 substrate binding pocket [chemical binding]; other site 762376013476 hinge residues; other site 762376013477 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 762376013478 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 762376013479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376013480 putative active site [active] 762376013481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376013482 heme pocket [chemical binding]; other site 762376013483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376013484 dimer interface [polypeptide binding]; other site 762376013485 phosphorylation site [posttranslational modification] 762376013486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376013487 ATP binding site [chemical binding]; other site 762376013488 G-X-G motif; other site 762376013489 Response regulator receiver domain; Region: Response_reg; pfam00072 762376013490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376013491 active site 762376013492 phosphorylation site [posttranslational modification] 762376013493 intermolecular recognition site; other site 762376013494 dimerization interface [polypeptide binding]; other site 762376013495 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 762376013496 substrate binding site [chemical binding]; other site 762376013497 activation loop (A-loop); other site 762376013498 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762376013499 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376013500 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376013501 catalytic residue [active] 762376013502 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376013503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376013504 dimerization interface [polypeptide binding]; other site 762376013505 putative DNA binding site [nucleotide binding]; other site 762376013506 putative Zn2+ binding site [ion binding]; other site 762376013507 AsnC family; Region: AsnC_trans_reg; pfam01037 762376013508 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 762376013509 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 762376013510 trimer interface [polypeptide binding]; other site 762376013511 eyelet of channel; other site 762376013512 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376013513 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376013514 DNA binding site [nucleotide binding] 762376013515 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 762376013516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376013517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376013518 putative transposase OrfB; Reviewed; Region: PHA02517 762376013519 HTH-like domain; Region: HTH_21; pfam13276 762376013520 Integrase core domain; Region: rve; pfam00665 762376013521 Integrase core domain; Region: rve_3; pfam13683 762376013522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376013523 Transposase; Region: HTH_Tnp_1; cl17663 762376013524 haemagglutination activity domain; Region: Haemagg_act; pfam05860 762376013525 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 762376013526 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 762376013527 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 762376013528 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 762376013529 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 762376013530 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 762376013531 MarR family; Region: MarR_2; cl17246 762376013532 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 762376013533 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376013534 Walker A/P-loop; other site 762376013535 ATP binding site [chemical binding]; other site 762376013536 Q-loop/lid; other site 762376013537 ABC transporter signature motif; other site 762376013538 Walker B; other site 762376013539 D-loop; other site 762376013540 H-loop/switch region; other site 762376013541 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762376013542 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376013543 Walker A/P-loop; other site 762376013544 ATP binding site [chemical binding]; other site 762376013545 Q-loop/lid; other site 762376013546 ABC transporter signature motif; other site 762376013547 Walker B; other site 762376013548 D-loop; other site 762376013549 H-loop/switch region; other site 762376013550 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376013551 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376013552 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 762376013553 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376013554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376013555 dimer interface [polypeptide binding]; other site 762376013556 conserved gate region; other site 762376013557 putative PBP binding loops; other site 762376013558 ABC-ATPase subunit interface; other site 762376013559 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762376013560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376013561 dimer interface [polypeptide binding]; other site 762376013562 conserved gate region; other site 762376013563 putative PBP binding loops; other site 762376013564 ABC-ATPase subunit interface; other site 762376013565 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_5; cd06232 762376013566 putative active site [active] 762376013567 Zn binding site [ion binding]; other site 762376013568 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762376013569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376013570 Coenzyme A binding pocket [chemical binding]; other site 762376013571 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 762376013572 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762376013573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376013574 S-adenosylmethionine binding site [chemical binding]; other site 762376013575 Transglycosylase SLT domain; Region: SLT_2; pfam13406 762376013576 murein hydrolase B; Provisional; Region: PRK10760; cl17906 762376013577 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 762376013578 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 762376013579 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 762376013580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376013583 dimerization interface [polypeptide binding]; other site 762376013584 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 762376013585 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 762376013586 active site 762376013587 purine riboside binding site [chemical binding]; other site 762376013588 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 762376013589 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 762376013590 substrate binding pocket [chemical binding]; other site 762376013591 catalytic triad [active] 762376013592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013593 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376013594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376013595 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376013596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376013597 putative substrate translocation pore; other site 762376013598 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 762376013599 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376013600 metal binding site [ion binding]; metal-binding site 762376013601 putative dimer interface [polypeptide binding]; other site 762376013602 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762376013603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376013604 Coenzyme A binding pocket [chemical binding]; other site 762376013605 putative L-aspartate dehydrogenase; Provisional; Region: PRK13302 762376013606 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 762376013607 Domain of unknown function DUF108; Region: DUF108; pfam01958 762376013608 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 762376013609 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 762376013610 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 762376013611 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376013612 RNA binding surface [nucleotide binding]; other site 762376013613 translation initiation factor Sui1; Validated; Region: PRK06824 762376013614 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 762376013615 putative rRNA binding site [nucleotide binding]; other site 762376013616 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 762376013617 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 762376013618 methionine gamma-lyase; Provisional; Region: PRK07503 762376013619 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762376013620 homodimer interface [polypeptide binding]; other site 762376013621 substrate-cofactor binding pocket; other site 762376013622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376013623 catalytic residue [active] 762376013624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376013625 dimer interface [polypeptide binding]; other site 762376013626 conserved gate region; other site 762376013627 ABC-ATPase subunit interface; other site 762376013628 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 762376013629 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 762376013630 Walker A/P-loop; other site 762376013631 ATP binding site [chemical binding]; other site 762376013632 Q-loop/lid; other site 762376013633 ABC transporter signature motif; other site 762376013634 Walker B; other site 762376013635 D-loop; other site 762376013636 H-loop/switch region; other site 762376013637 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 762376013638 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762376013639 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 762376013640 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 762376013641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376013642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376013643 putative substrate translocation pore; other site 762376013644 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376013645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376013646 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 762376013647 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 762376013648 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376013649 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 762376013650 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376013651 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 762376013652 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 762376013653 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 762376013654 hydroxyglutarate oxidase; Provisional; Region: PRK11728 762376013655 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 762376013656 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 762376013657 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 762376013658 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 762376013659 active site 762376013660 catalytic residues [active] 762376013661 metal binding site [ion binding]; metal-binding site 762376013662 DmpG-like communication domain; Region: DmpG_comm; pfam07836 762376013663 acetaldehyde dehydrogenase; Validated; Region: PRK08300 762376013664 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 762376013665 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 762376013666 DctM-like transporters; Region: DctM; pfam06808 762376013667 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 762376013668 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 762376013669 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 762376013670 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 762376013671 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376013672 FAD binding domain; Region: FAD_binding_4; pfam01565 762376013673 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376013674 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376013675 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376013676 L-aspartate oxidase; Provisional; Region: PRK09077 762376013677 L-aspartate oxidase; Provisional; Region: PRK06175 762376013678 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 762376013679 quinolinate synthetase; Provisional; Region: PRK09375 762376013680 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 762376013681 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 762376013682 multidrug resistance protein MdtN; Provisional; Region: PRK10476 762376013683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376013684 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376013685 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 762376013686 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 762376013687 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 762376013688 putative hydrophobic ligand binding site [chemical binding]; other site 762376013689 tellurite resistance protein TehB; Provisional; Region: PRK12335 762376013690 Uncharacterized conserved protein [Function unknown]; Region: COG5649 762376013691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376013694 dimerization interface [polypeptide binding]; other site 762376013695 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013696 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 762376013697 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 762376013698 active site 762376013699 putative substrate binding pocket [chemical binding]; other site 762376013700 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376013701 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376013702 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376013703 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013704 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 762376013705 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 762376013706 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 762376013707 active site 762376013708 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376013709 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 762376013710 conserved cys residue [active] 762376013711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376013712 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 762376013713 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 762376013714 putative dimer interface [polypeptide binding]; other site 762376013715 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376013716 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 762376013717 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 762376013718 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 762376013719 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 762376013720 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 762376013721 Cupin domain; Region: Cupin_2; cl17218 762376013722 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376013723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376013724 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376013725 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376013726 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 762376013727 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 762376013728 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 762376013729 DNA binding residues [nucleotide binding] 762376013730 putative dimer interface [polypeptide binding]; other site 762376013731 putative metal binding residues [ion binding]; other site 762376013732 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 762376013733 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 762376013734 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 762376013735 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376013736 putative C-terminal domain interface [polypeptide binding]; other site 762376013737 putative GSH binding site (G-site) [chemical binding]; other site 762376013738 putative dimer interface [polypeptide binding]; other site 762376013739 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 762376013740 putative N-terminal domain interface [polypeptide binding]; other site 762376013741 putative dimer interface [polypeptide binding]; other site 762376013742 putative substrate binding pocket (H-site) [chemical binding]; other site 762376013743 ABC-2 type transporter; Region: ABC2_membrane; cl17235 762376013744 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 762376013745 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762376013746 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762376013747 Walker A/P-loop; other site 762376013748 ATP binding site [chemical binding]; other site 762376013749 Q-loop/lid; other site 762376013750 ABC transporter signature motif; other site 762376013751 Walker B; other site 762376013752 D-loop; other site 762376013753 H-loop/switch region; other site 762376013754 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376013755 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762376013756 inhibitor site; inhibition site 762376013757 active site 762376013758 dimer interface [polypeptide binding]; other site 762376013759 catalytic residue [active] 762376013760 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 762376013761 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 762376013762 putative active site pocket [active] 762376013763 putative metal binding site [ion binding]; other site 762376013764 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 762376013765 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 762376013766 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376013768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013769 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 762376013770 putative dimerization interface [polypeptide binding]; other site 762376013771 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 762376013772 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 762376013773 PhnA protein; Region: PhnA; pfam03831 762376013774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 762376013775 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 762376013776 4Fe-4S binding domain; Region: Fer4_5; pfam12801 762376013777 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 762376013778 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 762376013779 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 762376013780 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 762376013781 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 762376013782 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 762376013783 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 762376013784 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 762376013785 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 762376013786 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 762376013787 Low-spin heme binding site [chemical binding]; other site 762376013788 Putative water exit pathway; other site 762376013789 Binuclear center (active site) [active] 762376013790 Putative proton exit pathway; other site 762376013791 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 762376013792 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762376013793 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376013794 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 762376013795 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376013796 inhibitor-cofactor binding pocket; inhibition site 762376013797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376013798 catalytic residue [active] 762376013799 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 762376013800 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 762376013801 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376013802 catalytic residue [active] 762376013803 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376013804 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 762376013805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376013806 S-adenosylmethionine binding site [chemical binding]; other site 762376013807 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 762376013808 AAA domain; Region: AAA_26; pfam13500 762376013809 isocitrate lyase; Provisional; Region: PRK15063 762376013810 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762376013811 tetramer interface [polypeptide binding]; other site 762376013812 active site 762376013813 Mg2+/Mn2+ binding site [ion binding]; other site 762376013814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 762376013815 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 762376013816 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 762376013817 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 762376013818 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 762376013819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376013820 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376013821 putative substrate translocation pore; other site 762376013822 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 762376013823 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 762376013824 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 762376013825 GIY-YIG motif/motif A; other site 762376013826 active site 762376013827 catalytic site [active] 762376013828 putative DNA binding site [nucleotide binding]; other site 762376013829 metal binding site [ion binding]; metal-binding site 762376013830 UvrB/uvrC motif; Region: UVR; pfam02151 762376013831 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 762376013832 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 762376013833 beta-hexosaminidase; Provisional; Region: PRK05337 762376013834 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 762376013835 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 762376013836 active site 762376013837 hydrophilic channel; other site 762376013838 dimerization interface [polypeptide binding]; other site 762376013839 catalytic residues [active] 762376013840 active site lid [active] 762376013841 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 762376013842 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 762376013843 Protein export membrane protein; Region: SecD_SecF; cl14618 762376013844 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 762376013845 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376013846 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376013847 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376013848 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 762376013849 DNA binding site [nucleotide binding] 762376013850 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 762376013851 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 762376013852 Patatin phospholipase; Region: DUF3734; pfam12536 762376013853 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 762376013854 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 762376013855 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 762376013856 TOBE domain; Region: TOBE; cl01440 762376013857 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 762376013858 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376013859 Walker A/P-loop; other site 762376013860 ATP binding site [chemical binding]; other site 762376013861 ABC transporter; Region: ABC_tran; pfam00005 762376013862 Q-loop/lid; other site 762376013863 ABC transporter signature motif; other site 762376013864 Walker B; other site 762376013865 D-loop; other site 762376013866 H-loop/switch region; other site 762376013867 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 762376013868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376013869 putative PBP binding loops; other site 762376013870 ABC-ATPase subunit interface; other site 762376013871 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 762376013872 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762376013873 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 762376013874 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 762376013875 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 762376013876 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 762376013877 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 762376013878 spermidine synthase; Provisional; Region: PRK03612 762376013879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376013880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762376013881 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 762376013882 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376013883 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 762376013884 NAD(P) binding pocket [chemical binding]; other site 762376013885 hydroxyglutarate oxidase; Provisional; Region: PRK11728 762376013886 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 762376013887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376013888 Walker A/P-loop; other site 762376013889 ATP binding site [chemical binding]; other site 762376013890 Q-loop/lid; other site 762376013891 ABC transporter signature motif; other site 762376013892 Walker B; other site 762376013893 D-loop; other site 762376013894 H-loop/switch region; other site 762376013895 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376013896 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 762376013897 TM-ABC transporter signature motif; other site 762376013898 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 762376013899 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 762376013900 zinc binding site [ion binding]; other site 762376013901 putative ligand binding site [chemical binding]; other site 762376013902 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762376013903 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762376013904 active site 762376013905 catalytic tetrad [active] 762376013906 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376013907 malonyl-CoA synthase; Validated; Region: PRK07514 762376013908 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 762376013909 acyl-activating enzyme (AAE) consensus motif; other site 762376013910 active site 762376013911 AMP binding site [chemical binding]; other site 762376013912 CoA binding site [chemical binding]; other site 762376013913 enoyl-CoA hydratase; Provisional; Region: PRK06127 762376013914 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376013915 substrate binding site [chemical binding]; other site 762376013916 oxyanion hole (OAH) forming residues; other site 762376013917 trimer interface [polypeptide binding]; other site 762376013918 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 762376013919 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 762376013920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376013921 DNA-binding site [nucleotide binding]; DNA binding site 762376013922 FCD domain; Region: FCD; pfam07729 762376013923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762376013924 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376013925 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376013926 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376013927 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376013928 active site 762376013929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376013930 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 762376013931 CoA binding domain; Region: CoA_binding_2; pfam13380 762376013932 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762376013933 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762376013934 enoyl-CoA hydratase; Provisional; Region: PRK08290 762376013935 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376013936 substrate binding site [chemical binding]; other site 762376013937 oxyanion hole (OAH) forming residues; other site 762376013938 trimer interface [polypeptide binding]; other site 762376013939 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376013940 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376013941 beta-ketothiolase; Provisional; Region: PRK09051 762376013942 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376013943 dimer interface [polypeptide binding]; other site 762376013944 active site 762376013945 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376013946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376013947 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376013948 dimerization interface [polypeptide binding]; other site 762376013949 substrate binding pocket [chemical binding]; other site 762376013950 FOG: CBS domain [General function prediction only]; Region: COG0517 762376013951 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 762376013952 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 762376013953 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 762376013954 substrate binding site [chemical binding]; other site 762376013955 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 762376013956 substrate binding site [chemical binding]; other site 762376013957 ligand binding site [chemical binding]; other site 762376013958 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762376013959 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376013960 catalytic residue [active] 762376013961 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376013962 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376013963 N-terminal plug; other site 762376013964 ligand-binding site [chemical binding]; other site 762376013965 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376013966 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376013967 MlrC C-terminus; Region: MlrC_C; pfam07171 762376013968 allantoate amidohydrolase; Reviewed; Region: PRK09290 762376013969 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 762376013970 active site 762376013971 metal binding site [ion binding]; metal-binding site 762376013972 dimer interface [polypeptide binding]; other site 762376013973 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376013974 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376013975 Walker A/P-loop; other site 762376013976 ATP binding site [chemical binding]; other site 762376013977 Q-loop/lid; other site 762376013978 ABC transporter signature motif; other site 762376013979 Walker B; other site 762376013980 D-loop; other site 762376013981 H-loop/switch region; other site 762376013982 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376013983 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376013984 Walker A/P-loop; other site 762376013985 ATP binding site [chemical binding]; other site 762376013986 Q-loop/lid; other site 762376013987 ABC transporter signature motif; other site 762376013988 Walker B; other site 762376013989 D-loop; other site 762376013990 H-loop/switch region; other site 762376013991 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376013992 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376013993 TM-ABC transporter signature motif; other site 762376013994 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376013995 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376013996 TM-ABC transporter signature motif; other site 762376013997 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376013998 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376013999 putative ligand binding site [chemical binding]; other site 762376014000 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376014001 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376014002 DNA-binding site [nucleotide binding]; DNA binding site 762376014003 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376014004 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014005 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 762376014006 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376014007 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 762376014008 acyl-activating enzyme (AAE) consensus motif; other site 762376014009 putative AMP binding site [chemical binding]; other site 762376014010 putative active site [active] 762376014011 putative CoA binding site [chemical binding]; other site 762376014012 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 762376014013 short chain dehydrogenase; Provisional; Region: PRK07677 762376014014 NAD(P) binding site [chemical binding]; other site 762376014015 substrate binding site [chemical binding]; other site 762376014016 homotetramer interface [polypeptide binding]; other site 762376014017 active site 762376014018 homodimer interface [polypeptide binding]; other site 762376014019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376014020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376014021 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376014022 putative effector binding pocket; other site 762376014023 dimerization interface [polypeptide binding]; other site 762376014024 aconitate hydratase; Provisional; Region: acnA; PRK12881 762376014025 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 762376014026 substrate binding site [chemical binding]; other site 762376014027 ligand binding site [chemical binding]; other site 762376014028 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 762376014029 substrate binding site [chemical binding]; other site 762376014030 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 762376014031 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 762376014032 putative active site [active] 762376014033 metal binding site [ion binding]; metal-binding site 762376014034 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 762376014035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 762376014036 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 762376014037 elongation factor P; Validated; Region: PRK00529 762376014038 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 762376014039 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 762376014040 RNA binding site [nucleotide binding]; other site 762376014041 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 762376014042 RNA binding site [nucleotide binding]; other site 762376014043 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 762376014044 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 762376014045 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 762376014046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376014047 Walker A motif; other site 762376014048 ATP binding site [chemical binding]; other site 762376014049 Walker B motif; other site 762376014050 arginine finger; other site 762376014051 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 762376014052 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 762376014053 TPR repeat; Region: TPR_11; pfam13414 762376014054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762376014055 binding surface 762376014056 TPR motif; other site 762376014057 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 762376014058 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 762376014059 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 762376014060 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 762376014061 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 762376014062 ATP binding site [chemical binding]; other site 762376014063 Walker A motif; other site 762376014064 hexamer interface [polypeptide binding]; other site 762376014065 Walker B motif; other site 762376014066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376014067 Response regulator receiver domain; Region: Response_reg; pfam00072 762376014068 active site 762376014069 phosphorylation site [posttranslational modification] 762376014070 intermolecular recognition site; other site 762376014071 dimerization interface [polypeptide binding]; other site 762376014072 AAA domain; Region: AAA_31; pfam13614 762376014073 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 762376014074 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 762376014075 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 762376014076 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 762376014077 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 762376014078 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 762376014079 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 762376014080 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 762376014081 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 762376014082 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 762376014083 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 762376014084 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 762376014085 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376014086 MarR family; Region: MarR_2; pfam12802 762376014087 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376014088 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376014089 Walker A/P-loop; other site 762376014090 ATP binding site [chemical binding]; other site 762376014091 Q-loop/lid; other site 762376014092 ABC transporter signature motif; other site 762376014093 Walker B; other site 762376014094 D-loop; other site 762376014095 H-loop/switch region; other site 762376014096 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376014097 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376014098 Walker A/P-loop; other site 762376014099 ATP binding site [chemical binding]; other site 762376014100 Q-loop/lid; other site 762376014101 ABC transporter signature motif; other site 762376014102 Walker B; other site 762376014103 D-loop; other site 762376014104 H-loop/switch region; other site 762376014105 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762376014106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376014107 dimer interface [polypeptide binding]; other site 762376014108 conserved gate region; other site 762376014109 putative PBP binding loops; other site 762376014110 ABC-ATPase subunit interface; other site 762376014111 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376014112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376014113 dimer interface [polypeptide binding]; other site 762376014114 conserved gate region; other site 762376014115 putative PBP binding loops; other site 762376014116 ABC-ATPase subunit interface; other site 762376014117 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 762376014118 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376014119 Staphylococcal nuclease homologues; Region: SNc; smart00318 762376014120 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 762376014121 Catalytic site; other site 762376014122 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 762376014123 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 762376014124 oligomer interface [polypeptide binding]; other site 762376014125 metal binding site [ion binding]; metal-binding site 762376014126 metal binding site [ion binding]; metal-binding site 762376014127 putative Cl binding site [ion binding]; other site 762376014128 basic sphincter; other site 762376014129 hydrophobic gate; other site 762376014130 periplasmic entrance; other site 762376014131 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 762376014132 Part of AAA domain; Region: AAA_19; pfam13245 762376014133 Family description; Region: UvrD_C_2; pfam13538 762376014134 Protein of unknown function DUF72; Region: DUF72; pfam01904 762376014135 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376014136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376014137 DNA-binding site [nucleotide binding]; DNA binding site 762376014138 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376014139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376014140 homodimer interface [polypeptide binding]; other site 762376014141 catalytic residue [active] 762376014142 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 762376014143 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376014144 inhibitor-cofactor binding pocket; inhibition site 762376014145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376014146 catalytic residue [active] 762376014147 succinic semialdehyde dehydrogenase; Region: PLN02278 762376014148 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762376014149 tetramerization interface [polypeptide binding]; other site 762376014150 NAD(P) binding site [chemical binding]; other site 762376014151 catalytic residues [active] 762376014152 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 762376014153 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 762376014154 active site 762376014155 putative lithium-binding site [ion binding]; other site 762376014156 substrate binding site [chemical binding]; other site 762376014157 NAD-dependent deacetylase; Provisional; Region: PRK05333 762376014158 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 762376014159 NAD+ binding site [chemical binding]; other site 762376014160 substrate binding site [chemical binding]; other site 762376014161 Zn binding site [ion binding]; other site 762376014162 serine O-acetyltransferase; Region: cysE; TIGR01172 762376014163 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 762376014164 trimer interface [polypeptide binding]; other site 762376014165 active site 762376014166 substrate binding site [chemical binding]; other site 762376014167 CoA binding site [chemical binding]; other site 762376014168 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 762376014169 UDP-glucose 4-epimerase; Region: PLN02240 762376014170 NAD binding site [chemical binding]; other site 762376014171 homodimer interface [polypeptide binding]; other site 762376014172 active site 762376014173 substrate binding site [chemical binding]; other site 762376014174 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 762376014175 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 762376014176 active site 762376014177 dimer interface [polypeptide binding]; other site 762376014178 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 762376014179 dimer interface [polypeptide binding]; other site 762376014180 active site 762376014181 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 762376014182 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 762376014183 active site 762376014184 substrate binding site [chemical binding]; other site 762376014185 metal binding site [ion binding]; metal-binding site 762376014186 tyrosine kinase; Provisional; Region: PRK11519 762376014187 Chain length determinant protein; Region: Wzz; pfam02706 762376014188 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 762376014189 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762376014190 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 762376014191 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 762376014192 SLBB domain; Region: SLBB; pfam10531 762376014193 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 762376014194 Bacterial sugar transferase; Region: Bac_transf; pfam02397 762376014195 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762376014196 nudix motif; other site 762376014197 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 762376014198 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 762376014199 Substrate binding site; other site 762376014200 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 762376014201 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 762376014202 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 762376014203 NADP-binding site; other site 762376014204 homotetramer interface [polypeptide binding]; other site 762376014205 substrate binding site [chemical binding]; other site 762376014206 homodimer interface [polypeptide binding]; other site 762376014207 active site 762376014208 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 762376014209 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 762376014210 NADP binding site [chemical binding]; other site 762376014211 active site 762376014212 putative substrate binding site [chemical binding]; other site 762376014213 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 762376014214 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 762376014215 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762376014216 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 762376014217 metal-binding site 762376014218 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 762376014219 O-Antigen ligase; Region: Wzy_C; pfam04932 762376014220 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376014221 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 762376014222 putative ADP-binding pocket [chemical binding]; other site 762376014223 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 762376014224 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762376014225 putative metal binding site; other site 762376014226 putative acyl transferase; Provisional; Region: PRK10502 762376014227 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 762376014228 putative trimer interface [polypeptide binding]; other site 762376014229 putative active site [active] 762376014230 putative substrate binding site [chemical binding]; other site 762376014231 putative CoA binding site [chemical binding]; other site 762376014232 putative glycosyl transferase; Provisional; Region: PRK10307 762376014233 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 762376014234 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376014235 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376014236 dimerization interface [polypeptide binding]; other site 762376014237 DNA binding residues [nucleotide binding] 762376014238 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376014239 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376014240 DNA binding residues [nucleotide binding] 762376014241 dimerization interface [polypeptide binding]; other site 762376014242 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 762376014243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376014244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376014245 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 762376014246 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376014247 active site 762376014248 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 762376014249 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 762376014250 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376014251 dimer interface [polypeptide binding]; other site 762376014252 active site 762376014253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376014254 fatty oxidation complex, alpha subunit FadB; Region: FadB; TIGR02437 762376014255 substrate binding site [chemical binding]; other site 762376014256 oxyanion hole (OAH) forming residues; other site 762376014257 trimer interface [polypeptide binding]; other site 762376014258 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376014259 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376014260 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 762376014261 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 762376014262 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376014263 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376014264 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376014265 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376014266 substrate binding site [chemical binding]; other site 762376014267 oxyanion hole (OAH) forming residues; other site 762376014268 trimer interface [polypeptide binding]; other site 762376014269 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 762376014270 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376014271 dimer interface [polypeptide binding]; other site 762376014272 active site 762376014273 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376014274 active site 2 [active] 762376014275 active site 1 [active] 762376014276 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 762376014277 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 762376014278 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 762376014279 acyl-activating enzyme (AAE) consensus motif; other site 762376014280 putative AMP binding site [chemical binding]; other site 762376014281 putative active site [active] 762376014282 putative CoA binding site [chemical binding]; other site 762376014283 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376014284 Sulfatase; Region: Sulfatase; cl17466 762376014285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014286 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376014287 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 762376014288 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376014289 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376014290 N-terminal plug; other site 762376014291 ligand-binding site [chemical binding]; other site 762376014292 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 762376014293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 762376014294 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 762376014295 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 762376014296 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376014297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376014298 DNA-binding site [nucleotide binding]; DNA binding site 762376014299 UTRA domain; Region: UTRA; pfam07702 762376014300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376014301 DNA-binding site [nucleotide binding]; DNA binding site 762376014302 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376014303 FCD domain; Region: FCD; pfam07729 762376014304 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376014305 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376014306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014307 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 762376014308 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376014309 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376014310 acyl-activating enzyme (AAE) consensus motif; other site 762376014311 acyl-activating enzyme (AAE) consensus motif; other site 762376014312 AMP binding site [chemical binding]; other site 762376014313 active site 762376014314 CoA binding site [chemical binding]; other site 762376014315 Coenzyme A transferase; Region: CoA_trans; cl17247 762376014316 Coenzyme A transferase; Region: CoA_trans; smart00882 762376014317 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376014318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376014319 substrate binding site [chemical binding]; other site 762376014320 oxyanion hole (OAH) forming residues; other site 762376014321 trimer interface [polypeptide binding]; other site 762376014322 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376014323 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376014324 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014325 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376014326 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376014327 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376014328 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 762376014329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376014330 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376014331 non-specific DNA binding site [nucleotide binding]; other site 762376014332 salt bridge; other site 762376014333 sequence-specific DNA binding site [nucleotide binding]; other site 762376014334 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 762376014335 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 762376014336 Uncharacterized conserved protein [Function unknown]; Region: COG5361 762376014337 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 762376014338 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 762376014339 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 762376014340 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376014341 active site residue [active] 762376014342 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762376014343 Walker A motif; other site 762376014344 aspartate kinase; Reviewed; Region: PRK06635 762376014345 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 762376014346 putative Mg ion binding site [ion binding]; other site 762376014347 putative aspartate binding site [chemical binding]; other site 762376014348 putative catalytic residues [active] 762376014349 putative nucleotide binding site [chemical binding]; other site 762376014350 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 762376014351 putative allosteric regulatory site; other site 762376014352 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 762376014353 putative allosteric regulatory residue; other site 762376014354 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 762376014355 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 762376014356 Ligand Binding Site [chemical binding]; other site 762376014357 TilS substrate binding domain; Region: TilS; pfam09179 762376014358 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 762376014359 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 762376014360 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762376014361 endonuclease III; Region: ENDO3c; smart00478 762376014362 minor groove reading motif; other site 762376014363 helix-hairpin-helix signature motif; other site 762376014364 substrate binding pocket [chemical binding]; other site 762376014365 active site 762376014366 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 762376014367 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762376014368 active site 762376014369 HIGH motif; other site 762376014370 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762376014371 KMSKS motif; other site 762376014372 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 762376014373 tRNA binding surface [nucleotide binding]; other site 762376014374 anticodon binding site; other site 762376014375 TPR repeat; Region: TPR_11; pfam13414 762376014376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762376014377 binding surface 762376014378 TPR motif; other site 762376014379 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 762376014380 substrate binding site [chemical binding]; other site 762376014381 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 762376014382 putative active site [active] 762376014383 putative metal binding site [ion binding]; other site 762376014384 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 762376014385 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 762376014386 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 762376014387 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762376014388 Transporter associated domain; Region: CorC_HlyC; pfam03471 762376014389 azurin; Region: azurin; TIGR02695 762376014390 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 762376014391 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 762376014392 4Fe-4S binding domain; Region: Fer4_5; pfam12801 762376014393 nitrous-oxide reductase; Validated; Region: PRK02888 762376014394 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 762376014395 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 762376014396 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 762376014397 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762376014398 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762376014399 Walker A/P-loop; other site 762376014400 ATP binding site [chemical binding]; other site 762376014401 Q-loop/lid; other site 762376014402 ABC transporter signature motif; other site 762376014403 Walker B; other site 762376014404 D-loop; other site 762376014405 H-loop/switch region; other site 762376014406 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 762376014407 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 762376014408 NosL; Region: NosL; cl01769 762376014409 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 762376014410 ApbE family; Region: ApbE; pfam02424 762376014411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376014412 Helix-turn-helix domain; Region: HTH_28; pfam13518 762376014413 Helix-turn-helix domain; Region: HTH_28; pfam13518 762376014414 putative transposase OrfB; Reviewed; Region: PHA02517 762376014415 HTH-like domain; Region: HTH_21; pfam13276 762376014416 Integrase core domain; Region: rve; pfam00665 762376014417 Integrase core domain; Region: rve_2; pfam13333 762376014418 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 762376014419 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 762376014420 active site 762376014421 dimerization interface [polypeptide binding]; other site 762376014422 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 762376014423 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 762376014424 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014425 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376014426 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376014427 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 762376014428 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762376014429 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 762376014430 Imelysin; Region: Peptidase_M75; cl09159 762376014431 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 762376014432 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 762376014433 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 762376014434 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376014435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376014436 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376014437 putative dimerization interface [polypeptide binding]; other site 762376014438 aldolase II superfamily protein; Provisional; Region: PRK07044 762376014439 intersubunit interface [polypeptide binding]; other site 762376014440 active site 762376014441 Zn2+ binding site [ion binding]; other site 762376014442 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014443 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 762376014444 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762376014445 NAD binding site [chemical binding]; other site 762376014446 ligand binding site [chemical binding]; other site 762376014447 catalytic site [active] 762376014448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376014449 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376014450 putative substrate translocation pore; other site 762376014451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376014452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376014453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376014454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376014455 dimerization interface [polypeptide binding]; other site 762376014456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376014457 DNA-binding site [nucleotide binding]; DNA binding site 762376014458 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 762376014459 FCD domain; Region: FCD; pfam07729 762376014460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 762376014461 Predicted flavoprotein [General function prediction only]; Region: COG0431 762376014462 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762376014463 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 762376014464 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 762376014465 Dodecin; Region: Dodecin; pfam07311 762376014466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376014467 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376014468 putative effector binding pocket; other site 762376014469 dimerization interface [polypeptide binding]; other site 762376014470 short chain dehydrogenase; Provisional; Region: PRK06125 762376014471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376014472 NAD(P) binding site [chemical binding]; other site 762376014473 active site 762376014474 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 762376014475 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 762376014476 putative NAD(P) binding site [chemical binding]; other site 762376014477 dimer interface [polypeptide binding]; other site 762376014478 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 762376014479 active site 762376014480 catalytic residues [active] 762376014481 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376014482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376014483 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376014484 dimerization interface [polypeptide binding]; other site 762376014485 substrate binding pocket [chemical binding]; other site 762376014486 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 762376014487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376014488 NAD(P) binding site [chemical binding]; other site 762376014489 active site 762376014490 fumarylacetoacetase; Region: PLN02856 762376014491 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 762376014492 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376014493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014494 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 762376014495 MutS domain I; Region: MutS_I; pfam01624 762376014496 MutS domain II; Region: MutS_II; pfam05188 762376014497 MutS domain III; Region: MutS_III; pfam05192 762376014498 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 762376014499 Walker A/P-loop; other site 762376014500 ATP binding site [chemical binding]; other site 762376014501 Q-loop/lid; other site 762376014502 ABC transporter signature motif; other site 762376014503 Walker B; other site 762376014504 D-loop; other site 762376014505 H-loop/switch region; other site 762376014506 Cupin superfamily protein; Region: Cupin_4; pfam08007 762376014507 Cupin-like domain; Region: Cupin_8; pfam13621 762376014508 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 762376014509 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 762376014510 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762376014511 dihydrodipicolinate synthase; Region: dapA; TIGR00674 762376014512 dimer interface [polypeptide binding]; other site 762376014513 active site 762376014514 catalytic residue [active] 762376014515 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 762376014516 Peptidase family M50; Region: Peptidase_M50; pfam02163 762376014517 active site 762376014518 putative substrate binding region [chemical binding]; other site 762376014519 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 762376014520 Predicted metalloprotease [General function prediction only]; Region: COG2321 762376014521 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 762376014522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376014523 putative DNA binding site [nucleotide binding]; other site 762376014524 putative Zn2+ binding site [ion binding]; other site 762376014525 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 762376014526 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762376014527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376014528 Coenzyme A binding pocket [chemical binding]; other site 762376014529 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 762376014530 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 762376014531 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 762376014532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376014533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376014534 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376014535 putative dimerization interface [polypeptide binding]; other site 762376014536 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 762376014537 active site 762376014538 catalytic residues [active] 762376014539 metal binding site [ion binding]; metal-binding site 762376014540 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 762376014541 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 762376014542 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 762376014543 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 762376014544 DctM-like transporters; Region: DctM; pfam06808 762376014545 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 762376014546 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376014547 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376014548 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014549 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 762376014550 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 762376014551 Baseplate J-like protein; Region: Baseplate_J; cl01294 762376014552 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 762376014553 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 762376014554 Predicted transcriptional regulator [Transcription]; Region: COG2932 762376014555 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 762376014556 Catalytic site [active] 762376014557 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 762376014558 active site 762376014559 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 762376014560 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 762376014561 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 762376014562 putative active site [active] 762376014563 catalytic site [active] 762376014564 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 762376014565 putative active site [active] 762376014566 catalytic site [active] 762376014567 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376014568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376014569 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376014570 putative dimerization interface [polypeptide binding]; other site 762376014571 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376014572 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376014573 substrate binding site [chemical binding]; other site 762376014574 oxyanion hole (OAH) forming residues; other site 762376014575 trimer interface [polypeptide binding]; other site 762376014576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014577 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376014578 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376014579 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014580 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376014581 CoenzymeA binding site [chemical binding]; other site 762376014582 subunit interaction site [polypeptide binding]; other site 762376014583 PHB binding site; other site 762376014584 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376014585 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 762376014586 substrate binding site [chemical binding]; other site 762376014587 oxyanion hole (OAH) forming residues; other site 762376014588 trimer interface [polypeptide binding]; other site 762376014589 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376014590 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376014591 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376014592 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376014593 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376014594 active site 762376014595 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376014596 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376014597 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376014598 active site 762376014599 Coenzyme A transferase; Region: CoA_trans; cl17247 762376014600 Coenzyme A transferase; Region: CoA_trans; cl17247 762376014601 thiolase; Provisional; Region: PRK06158 762376014602 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376014603 active site 762376014604 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376014605 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376014606 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376014607 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762376014608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376014609 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376014610 EamA-like transporter family; Region: EamA; pfam00892 762376014611 Uncharacterized conserved protein [Function unknown]; Region: COG3542 762376014612 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376014613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376014614 DNA-binding site [nucleotide binding]; DNA binding site 762376014615 FCD domain; Region: FCD; pfam07729 762376014616 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014617 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 762376014618 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376014619 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 762376014620 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 762376014621 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 762376014622 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 762376014623 Ligand binding site; other site 762376014624 Putative Catalytic site; other site 762376014625 DXD motif; other site 762376014626 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 762376014627 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 762376014628 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376014629 Outer membrane efflux protein; Region: OEP; pfam02321 762376014630 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 762376014631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376014632 active site 762376014633 phosphorylation site [posttranslational modification] 762376014634 intermolecular recognition site; other site 762376014635 dimerization interface [polypeptide binding]; other site 762376014636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376014637 DNA binding site [nucleotide binding] 762376014638 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 762376014639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 762376014640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376014641 dimer interface [polypeptide binding]; other site 762376014642 phosphorylation site [posttranslational modification] 762376014643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376014644 ATP binding site [chemical binding]; other site 762376014645 Mg2+ binding site [ion binding]; other site 762376014646 G-X-G motif; other site 762376014647 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 762376014648 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 762376014649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 762376014650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376014651 membrane-bound complex binding site; other site 762376014652 hinge residues; other site 762376014653 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 762376014654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376014655 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 762376014656 substrate binding pocket [chemical binding]; other site 762376014657 dimerization interface [polypeptide binding]; other site 762376014658 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 762376014659 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 762376014660 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 762376014661 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 762376014662 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 762376014663 thiamine pyrophosphate protein; Validated; Region: PRK08199 762376014664 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376014665 PYR/PP interface [polypeptide binding]; other site 762376014666 dimer interface [polypeptide binding]; other site 762376014667 TPP binding site [chemical binding]; other site 762376014668 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376014669 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 762376014670 TPP-binding site [chemical binding]; other site 762376014671 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 762376014672 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 762376014673 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 762376014674 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376014675 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376014676 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376014677 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376014678 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376014679 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 762376014680 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 762376014681 active site 762376014682 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 762376014683 dimer interface [polypeptide binding]; other site 762376014684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014685 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 762376014686 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014687 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 762376014688 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376014689 PRC-barrel domain; Region: PRC; pfam05239 762376014690 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762376014691 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 762376014692 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376014693 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376014694 OsmC-like protein; Region: OsmC; pfam02566 762376014695 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014696 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376014697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376014698 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 762376014699 Cysteine-rich domain; Region: CCG; pfam02754 762376014700 Cysteine-rich domain; Region: CCG; pfam02754 762376014701 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376014702 FAD binding domain; Region: FAD_binding_4; pfam01565 762376014703 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 762376014704 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 762376014705 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 762376014706 NAD(P) binding site [chemical binding]; other site 762376014707 active site 762376014708 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014709 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 762376014710 Strictosidine synthase; Region: Str_synth; pfam03088 762376014711 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 762376014712 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376014713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376014714 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376014715 putative dimerization interface [polypeptide binding]; other site 762376014716 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 762376014717 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 762376014718 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 762376014719 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762376014720 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 762376014721 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 762376014722 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762376014723 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 762376014724 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 762376014725 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 762376014726 XdhC Rossmann domain; Region: XdhC_C; pfam13478 762376014727 YcfA-like protein; Region: YcfA; pfam07927 762376014728 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 762376014729 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 762376014730 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376014731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376014732 sequence-specific DNA binding site [nucleotide binding]; other site 762376014733 salt bridge; other site 762376014734 Cupin domain; Region: Cupin_2; pfam07883 762376014735 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 762376014736 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376014737 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376014738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376014739 dimer interface [polypeptide binding]; other site 762376014740 conserved gate region; other site 762376014741 putative PBP binding loops; other site 762376014742 ABC-ATPase subunit interface; other site 762376014743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376014744 dimer interface [polypeptide binding]; other site 762376014745 conserved gate region; other site 762376014746 putative PBP binding loops; other site 762376014747 ABC-ATPase subunit interface; other site 762376014748 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376014749 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376014750 substrate binding pocket [chemical binding]; other site 762376014751 membrane-bound complex binding site; other site 762376014752 hinge residues; other site 762376014753 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376014754 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376014755 Walker A/P-loop; other site 762376014756 ATP binding site [chemical binding]; other site 762376014757 Q-loop/lid; other site 762376014758 ABC transporter signature motif; other site 762376014759 Walker B; other site 762376014760 D-loop; other site 762376014761 H-loop/switch region; other site 762376014762 aldehyde dehydrogenase family 7 member; Region: PLN02315 762376014763 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 762376014764 tetrameric interface [polypeptide binding]; other site 762376014765 NAD binding site [chemical binding]; other site 762376014766 catalytic residues [active] 762376014767 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 762376014768 substrate binding site [chemical binding]; other site 762376014769 dimerization interface [polypeptide binding]; other site 762376014770 active site 762376014771 calcium binding site [ion binding]; other site 762376014772 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 762376014773 dimer interface [polypeptide binding]; other site 762376014774 pyridoxal binding site [chemical binding]; other site 762376014775 ATP binding site [chemical binding]; other site 762376014776 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 762376014777 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 762376014778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376014779 non-specific DNA binding site [nucleotide binding]; other site 762376014780 salt bridge; other site 762376014781 sequence-specific DNA binding site [nucleotide binding]; other site 762376014782 Cupin domain; Region: Cupin_2; pfam07883 762376014783 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 762376014784 intersubunit interface [polypeptide binding]; other site 762376014785 active site 762376014786 Zn2+ binding site [ion binding]; other site 762376014787 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376014788 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376014789 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 762376014790 N-terminal domain interface [polypeptide binding]; other site 762376014791 dimer interface [polypeptide binding]; other site 762376014792 substrate binding pocket (H-site) [chemical binding]; other site 762376014793 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014794 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376014795 dimerization interface [polypeptide binding]; other site 762376014796 putative DNA binding site [nucleotide binding]; other site 762376014797 putative Zn2+ binding site [ion binding]; other site 762376014798 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 762376014799 putative metal binding site [ion binding]; other site 762376014800 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 762376014801 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762376014802 active site 762376014803 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 762376014804 arsenical-resistance protein; Region: acr3; TIGR00832 762376014805 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376014806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376014807 putative substrate translocation pore; other site 762376014808 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 762376014809 ArsC family; Region: ArsC; pfam03960 762376014810 catalytic residues [active] 762376014811 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 762376014812 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762376014813 Nuclease-related domain; Region: NERD; pfam08378 762376014814 SEC-C motif; Region: SEC-C; pfam02810 762376014815 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376014816 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376014817 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 762376014818 DNA binding residues [nucleotide binding] 762376014819 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376014820 FecR protein; Region: FecR; pfam04773 762376014821 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376014822 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376014823 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376014824 N-terminal plug; other site 762376014825 ligand-binding site [chemical binding]; other site 762376014826 RNA polymerase sigma factor; Reviewed; Region: PRK12523 762376014827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376014828 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 762376014829 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376014830 FecR protein; Region: FecR; pfam04773 762376014831 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376014832 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376014833 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376014834 N-terminal plug; other site 762376014835 ligand-binding site [chemical binding]; other site 762376014836 Putative amidotransferase; Region: DUF4066; pfam13278 762376014837 conserved cys residue [active] 762376014838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376014839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376014840 Uncharacterized conserved protein [Function unknown]; Region: COG2128 762376014841 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762376014842 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 762376014843 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 762376014844 Autotransporter beta-domain; Region: Autotransporter; pfam03797 762376014845 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 762376014846 active site 762376014847 homotetramer interface [polypeptide binding]; other site 762376014848 homodimer interface [polypeptide binding]; other site 762376014849 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 762376014850 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376014851 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 762376014852 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376014853 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376014854 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376014855 N-terminal plug; other site 762376014856 ligand-binding site [chemical binding]; other site 762376014857 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376014858 FecR protein; Region: FecR; pfam04773 762376014859 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376014860 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376014861 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376014862 DNA binding residues [nucleotide binding] 762376014863 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376014864 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376014865 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 762376014866 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376014867 dimer interface [polypeptide binding]; other site 762376014868 active site 762376014869 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376014870 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376014871 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376014872 active site 762376014873 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376014874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376014875 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376014876 dimerization interface [polypeptide binding]; other site 762376014877 substrate binding pocket [chemical binding]; other site 762376014878 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014879 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014880 enoyl-CoA hydratase; Provisional; Region: PRK09245 762376014881 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376014882 substrate binding site [chemical binding]; other site 762376014883 oxyanion hole (OAH) forming residues; other site 762376014884 trimer interface [polypeptide binding]; other site 762376014885 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376014886 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376014887 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376014889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376014890 LysR substrate binding domain; Region: LysR_substrate; pfam03466 762376014891 dimerization interface [polypeptide binding]; other site 762376014892 short chain dehydrogenase; Provisional; Region: PRK07791 762376014893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376014894 NAD(P) binding site [chemical binding]; other site 762376014895 active site 762376014896 enoyl-CoA hydratase; Region: PLN02864 762376014897 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376014898 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 762376014899 dimer interaction site [polypeptide binding]; other site 762376014900 substrate-binding tunnel; other site 762376014901 active site 762376014902 catalytic site [active] 762376014903 substrate binding site [chemical binding]; other site 762376014904 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 762376014905 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 762376014906 dimer interface [polypeptide binding]; other site 762376014907 active site 762376014908 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376014909 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376014910 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 762376014911 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376014912 active site 762376014913 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376014914 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376014915 active site 762376014916 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376014917 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376014918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014919 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 762376014920 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 762376014921 active site residues [active] 762376014922 dimer interface [polypeptide binding]; other site 762376014923 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 762376014924 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 762376014925 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 762376014926 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 762376014927 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376014928 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 762376014929 acyl-activating enzyme (AAE) consensus motif; other site 762376014930 putative AMP binding site [chemical binding]; other site 762376014931 putative active site [active] 762376014932 putative CoA binding site [chemical binding]; other site 762376014933 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376014934 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376014935 active site 762376014936 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376014937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376014938 NAD(P) binding site [chemical binding]; other site 762376014939 active site 762376014940 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 762376014941 active site 762376014942 catalytic site [active] 762376014943 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376014944 active site 762376014945 catalytic site [active] 762376014946 lipid-transfer protein; Provisional; Region: PRK08256 762376014947 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376014948 active site 762376014949 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 762376014950 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376014951 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 762376014952 acyl-activating enzyme (AAE) consensus motif; other site 762376014953 acyl-activating enzyme (AAE) consensus motif; other site 762376014954 putative AMP binding site [chemical binding]; other site 762376014955 putative active site [active] 762376014956 putative CoA binding site [chemical binding]; other site 762376014957 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 762376014958 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376014959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376014960 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376014961 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376014962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376014963 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376014964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376014965 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376014966 dimerization interface [polypeptide binding]; other site 762376014967 substrate binding pocket [chemical binding]; other site 762376014968 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376014969 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376014970 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376014971 active site 762376014972 catalytic site [active] 762376014973 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376014974 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 762376014975 active site 1 [active] 762376014976 dimer interface [polypeptide binding]; other site 762376014977 hexamer interface [polypeptide binding]; other site 762376014978 active site 2 [active] 762376014979 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 762376014980 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 762376014981 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 762376014982 Walker A/P-loop; other site 762376014983 ATP binding site [chemical binding]; other site 762376014984 Q-loop/lid; other site 762376014985 ABC transporter signature motif; other site 762376014986 Walker B; other site 762376014987 D-loop; other site 762376014988 H-loop/switch region; other site 762376014989 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 762376014990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376014991 dimer interface [polypeptide binding]; other site 762376014992 conserved gate region; other site 762376014993 putative PBP binding loops; other site 762376014994 ABC-ATPase subunit interface; other site 762376014995 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 762376014996 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 762376014997 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 762376014998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376014999 S-adenosylmethionine binding site [chemical binding]; other site 762376015000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376015001 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 762376015002 putative substrate translocation pore; other site 762376015003 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 762376015004 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 762376015005 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376015006 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 762376015007 putative ligand binding site [chemical binding]; other site 762376015008 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376015009 TM-ABC transporter signature motif; other site 762376015010 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376015011 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376015012 TM-ABC transporter signature motif; other site 762376015013 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376015014 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376015015 Walker A/P-loop; other site 762376015016 ATP binding site [chemical binding]; other site 762376015017 Q-loop/lid; other site 762376015018 ABC transporter signature motif; other site 762376015019 Walker B; other site 762376015020 D-loop; other site 762376015021 H-loop/switch region; other site 762376015022 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 762376015023 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 762376015024 Sulfate transporter family; Region: Sulfate_transp; pfam00916 762376015025 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 762376015026 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 762376015027 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762376015028 tetramer interface [polypeptide binding]; other site 762376015029 active site 762376015030 Mg2+/Mn2+ binding site [ion binding]; other site 762376015031 Hemerythrin-like domain; Region: Hr-like; cd12108 762376015032 Fe binding site [ion binding]; other site 762376015033 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 762376015034 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 762376015035 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 762376015036 bacterial (prokaryotic) histone like domain; Region: BHL; smart00411 762376015037 IHF dimer interface [polypeptide binding]; other site 762376015038 IHF - DNA interface [nucleotide binding]; other site 762376015039 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376015040 MarR family; Region: MarR; pfam01047 762376015041 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376015042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376015043 putative substrate translocation pore; other site 762376015044 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 762376015045 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 762376015046 HIGH motif; other site 762376015047 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 762376015048 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762376015049 active site 762376015050 KMSKS motif; other site 762376015051 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 762376015052 tRNA binding surface [nucleotide binding]; other site 762376015053 Lipopolysaccharide-assembly; Region: LptE; cl01125 762376015054 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 762376015055 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 762376015056 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 762376015057 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 762376015058 putative catalytic cysteine [active] 762376015059 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376015060 amidase; Provisional; Region: PRK07487 762376015061 Amidase; Region: Amidase; cl11426 762376015062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376015063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376015064 LysR substrate binding domain; Region: LysR_substrate; pfam03466 762376015065 dimerization interface [polypeptide binding]; other site 762376015066 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376015067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376015068 putative substrate translocation pore; other site 762376015069 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 762376015070 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376015071 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376015072 Predicted acetyltransferase [General function prediction only]; Region: COG2388 762376015073 hypothetical protein; Provisional; Region: PRK01842 762376015074 SEC-C motif; Region: SEC-C; pfam02810 762376015075 hypothetical protein; Provisional; Region: PRK06486 762376015076 intersubunit interface [polypeptide binding]; other site 762376015077 active site 762376015078 Zn2+ binding site [ion binding]; other site 762376015079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376015080 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376015081 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 762376015082 dimerization interface [polypeptide binding]; other site 762376015083 substrate binding pocket [chemical binding]; other site 762376015084 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 762376015085 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 762376015086 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 762376015087 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376015088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376015089 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 762376015090 putative dimerization interface [polypeptide binding]; other site 762376015091 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 762376015092 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 762376015093 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762376015094 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 762376015095 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 762376015096 homodimer interface [polypeptide binding]; other site 762376015097 chemical substrate binding site [chemical binding]; other site 762376015098 oligomer interface [polypeptide binding]; other site 762376015099 metal binding site [ion binding]; metal-binding site 762376015100 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 762376015101 active site 762376015102 catalytic site [active] 762376015103 substrate binding site [chemical binding]; other site 762376015104 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 762376015105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376015106 PAS domain; Region: PAS_9; pfam13426 762376015107 putative active site [active] 762376015108 heme pocket [chemical binding]; other site 762376015109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762376015110 PAS domain; Region: PAS_9; pfam13426 762376015111 putative active site [active] 762376015112 heme pocket [chemical binding]; other site 762376015113 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376015114 dimer interface [polypeptide binding]; other site 762376015115 putative CheW interface [polypeptide binding]; other site 762376015116 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 762376015117 glutathione s-transferase; Provisional; Region: PTZ00057 762376015118 GSH binding site (G-site) [chemical binding]; other site 762376015119 C-terminal domain interface [polypeptide binding]; other site 762376015120 dimer interface [polypeptide binding]; other site 762376015121 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 762376015122 dimer interface [polypeptide binding]; other site 762376015123 N-terminal domain interface [polypeptide binding]; other site 762376015124 substrate binding pocket (H-site) [chemical binding]; other site 762376015125 Pleckstrin homology-like domain; Region: PH-like; cl17171 762376015126 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376015127 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 762376015128 conserved cys residue [active] 762376015129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376015130 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 762376015131 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 762376015132 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376015133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376015134 Walker A/P-loop; other site 762376015135 ATP binding site [chemical binding]; other site 762376015136 Q-loop/lid; other site 762376015137 ABC transporter signature motif; other site 762376015138 Walker B; other site 762376015139 D-loop; other site 762376015140 H-loop/switch region; other site 762376015141 TOBE domain; Region: TOBE_2; pfam08402 762376015142 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 762376015143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015144 dimer interface [polypeptide binding]; other site 762376015145 conserved gate region; other site 762376015146 putative PBP binding loops; other site 762376015147 ABC-ATPase subunit interface; other site 762376015148 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 762376015149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015150 dimer interface [polypeptide binding]; other site 762376015151 conserved gate region; other site 762376015152 putative PBP binding loops; other site 762376015153 ABC-ATPase subunit interface; other site 762376015154 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 762376015155 Proline racemase; Region: Pro_racemase; pfam05544 762376015156 choline dehydrogenase; Validated; Region: PRK02106 762376015157 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376015158 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 762376015159 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 762376015160 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 762376015161 shikimate binding site; other site 762376015162 NAD(P) binding site [chemical binding]; other site 762376015163 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762376015164 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 762376015165 PYR/PP interface [polypeptide binding]; other site 762376015166 dimer interface [polypeptide binding]; other site 762376015167 TPP binding site [chemical binding]; other site 762376015168 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376015169 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 762376015170 TPP-binding site [chemical binding]; other site 762376015171 dimer interface [polypeptide binding]; other site 762376015172 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376015173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376015174 DNA-binding site [nucleotide binding]; DNA binding site 762376015175 FCD domain; Region: FCD; pfam07729 762376015176 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 762376015177 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 762376015178 dimer interface [polypeptide binding]; other site 762376015179 active site 762376015180 metal binding site [ion binding]; metal-binding site 762376015181 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 762376015182 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 762376015183 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376015184 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376015185 short chain dehydrogenase; Provisional; Region: PRK12829 762376015186 classical (c) SDRs; Region: SDR_c; cd05233 762376015187 NAD(P) binding site [chemical binding]; other site 762376015188 active site 762376015189 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376015190 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376015191 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376015192 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376015193 TM-ABC transporter signature motif; other site 762376015194 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376015195 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376015196 TM-ABC transporter signature motif; other site 762376015197 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376015198 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376015199 Walker A/P-loop; other site 762376015200 ATP binding site [chemical binding]; other site 762376015201 Q-loop/lid; other site 762376015202 ABC transporter signature motif; other site 762376015203 Walker B; other site 762376015204 D-loop; other site 762376015205 H-loop/switch region; other site 762376015206 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376015207 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376015208 Walker A/P-loop; other site 762376015209 ATP binding site [chemical binding]; other site 762376015210 Q-loop/lid; other site 762376015211 ABC transporter signature motif; other site 762376015212 Walker B; other site 762376015213 D-loop; other site 762376015214 H-loop/switch region; other site 762376015215 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 762376015216 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 762376015217 NAD(P) binding site [chemical binding]; other site 762376015218 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762376015219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376015220 NAD(P) binding site [chemical binding]; other site 762376015221 active site 762376015222 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 762376015223 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762376015224 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762376015225 active site 762376015226 catalytic tetrad [active] 762376015227 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 762376015228 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376015229 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376015230 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 762376015231 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 762376015232 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376015233 catalytic residue [active] 762376015234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015235 dimer interface [polypeptide binding]; other site 762376015236 conserved gate region; other site 762376015237 putative PBP binding loops; other site 762376015238 ABC-ATPase subunit interface; other site 762376015239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015240 dimer interface [polypeptide binding]; other site 762376015241 ABC-ATPase subunit interface; other site 762376015242 putative PBP binding loops; other site 762376015243 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376015244 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376015245 Walker A/P-loop; other site 762376015246 ATP binding site [chemical binding]; other site 762376015247 Q-loop/lid; other site 762376015248 ABC transporter signature motif; other site 762376015249 Walker B; other site 762376015250 D-loop; other site 762376015251 H-loop/switch region; other site 762376015252 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376015253 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376015254 substrate binding pocket [chemical binding]; other site 762376015255 membrane-bound complex binding site; other site 762376015256 hinge residues; other site 762376015257 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 762376015258 homotrimer interaction site [polypeptide binding]; other site 762376015259 putative active site [active] 762376015260 Predicted deacylase [General function prediction only]; Region: COG3608 762376015261 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 762376015262 active site 762376015263 Zn binding site [ion binding]; other site 762376015264 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762376015265 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762376015266 DNA binding site [nucleotide binding] 762376015267 domain linker motif; other site 762376015268 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 762376015269 putative dimerization interface [polypeptide binding]; other site 762376015270 putative ligand binding site [chemical binding]; other site 762376015271 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762376015272 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376015273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376015274 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 762376015275 putative effector binding pocket; other site 762376015276 putative dimerization interface [polypeptide binding]; other site 762376015277 Isochorismatase family; Region: Isochorismatase; pfam00857 762376015278 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 762376015279 catalytic triad [active] 762376015280 dimer interface [polypeptide binding]; other site 762376015281 conserved cis-peptide bond; other site 762376015282 Isochorismatase family; Region: Isochorismatase; pfam00857 762376015283 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 762376015284 catalytic triad [active] 762376015285 dimer interface [polypeptide binding]; other site 762376015286 conserved cis-peptide bond; other site 762376015287 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 762376015288 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 762376015289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 762376015290 Lysine efflux permease [General function prediction only]; Region: COG1279 762376015291 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376015292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376015293 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 762376015294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762376015295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376015296 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376015297 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376015298 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376015299 Walker A/P-loop; other site 762376015300 ATP binding site [chemical binding]; other site 762376015301 Q-loop/lid; other site 762376015302 ABC transporter signature motif; other site 762376015303 Walker B; other site 762376015304 D-loop; other site 762376015305 H-loop/switch region; other site 762376015306 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376015307 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376015308 TM-ABC transporter signature motif; other site 762376015309 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376015310 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376015311 Walker A/P-loop; other site 762376015312 ATP binding site [chemical binding]; other site 762376015313 Q-loop/lid; other site 762376015314 ABC transporter signature motif; other site 762376015315 Walker B; other site 762376015316 D-loop; other site 762376015317 H-loop/switch region; other site 762376015318 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376015319 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376015320 TM-ABC transporter signature motif; other site 762376015321 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376015322 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376015323 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 762376015324 acyl-CoA synthetase; Validated; Region: PRK06145 762376015325 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376015326 acyl-activating enzyme (AAE) consensus motif; other site 762376015327 AMP binding site [chemical binding]; other site 762376015328 active site 762376015329 CoA binding site [chemical binding]; other site 762376015330 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376015331 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376015332 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376015333 active site 762376015334 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 762376015335 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376015336 E3 interaction surface; other site 762376015337 lipoyl attachment site [posttranslational modification]; other site 762376015338 e3 binding domain; Region: E3_binding; pfam02817 762376015339 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762376015340 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376015341 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376015342 substrate binding site [chemical binding]; other site 762376015343 oxyanion hole (OAH) forming residues; other site 762376015344 trimer interface [polypeptide binding]; other site 762376015345 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762376015346 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762376015347 alpha subunit interface [polypeptide binding]; other site 762376015348 TPP binding site [chemical binding]; other site 762376015349 heterodimer interface [polypeptide binding]; other site 762376015350 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376015351 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 762376015352 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762376015353 tetramer interface [polypeptide binding]; other site 762376015354 TPP-binding site [chemical binding]; other site 762376015355 heterodimer interface [polypeptide binding]; other site 762376015356 phosphorylation loop region [posttranslational modification] 762376015357 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376015358 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376015359 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376015360 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376015361 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376015362 substrate binding site [chemical binding]; other site 762376015363 oxyanion hole (OAH) forming residues; other site 762376015364 trimer interface [polypeptide binding]; other site 762376015365 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376015366 CoA binding domain; Region: CoA_binding_2; pfam13380 762376015367 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762376015368 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762376015369 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376015370 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376015371 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376015372 active site 762376015373 enoyl-CoA hydratase; Provisional; Region: PRK09245 762376015374 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376015375 substrate binding site [chemical binding]; other site 762376015376 oxyanion hole (OAH) forming residues; other site 762376015377 trimer interface [polypeptide binding]; other site 762376015378 thiolase; Provisional; Region: PRK06158 762376015379 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376015380 active site 762376015381 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376015382 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376015383 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376015384 active site 762376015385 catalytic site [active] 762376015386 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376015387 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376015388 active site 762376015389 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376015390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376015391 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 762376015392 putative substrate binding pocket [chemical binding]; other site 762376015393 dimerization interface [polypeptide binding]; other site 762376015394 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 762376015395 putative active site [active] 762376015396 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762376015397 carboxyltransferase (CT) interaction site; other site 762376015398 biotinylation site [posttranslational modification]; other site 762376015399 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 762376015400 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376015401 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762376015402 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 762376015403 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 762376015404 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 762376015405 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 762376015406 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 762376015407 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762376015408 Zn2+ binding site [ion binding]; other site 762376015409 Mg2+ binding site [ion binding]; other site 762376015410 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376015411 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376015412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376015413 DNA binding residues [nucleotide binding] 762376015414 fec operon regulator FecR; Reviewed; Region: PRK09774 762376015415 FecR protein; Region: FecR; pfam04773 762376015416 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376015417 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376015418 N-terminal plug; other site 762376015419 ligand-binding site [chemical binding]; other site 762376015420 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376015421 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 762376015422 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 762376015423 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376015424 nucleotide binding region [chemical binding]; other site 762376015425 ATP-binding site [chemical binding]; other site 762376015426 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 762376015427 active site 762376015428 putative substrate binding region [chemical binding]; other site 762376015429 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376015430 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376015431 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 762376015432 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 762376015433 SapC; Region: SapC; pfam07277 762376015434 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 762376015435 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376015436 active site 762376015437 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376015438 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376015439 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376015440 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 762376015441 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376015442 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 762376015443 acyl-activating enzyme (AAE) consensus motif; other site 762376015444 putative AMP binding site [chemical binding]; other site 762376015445 putative active site [active] 762376015446 putative CoA binding site [chemical binding]; other site 762376015447 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376015448 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376015449 ligand binding site [chemical binding]; other site 762376015450 flexible hinge region; other site 762376015451 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 762376015452 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 762376015453 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 762376015454 active site 762376015455 oxalacetate binding site [chemical binding]; other site 762376015456 citrylCoA binding site [chemical binding]; other site 762376015457 coenzyme A binding site [chemical binding]; other site 762376015458 catalytic triad [active] 762376015459 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376015460 CoA binding domain; Region: CoA_binding_2; pfam13380 762376015461 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762376015462 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762376015463 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376015464 active site 2 [active] 762376015465 active site 1 [active] 762376015466 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376015467 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376015468 active site 762376015469 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376015470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376015471 NAD(P) binding site [chemical binding]; other site 762376015472 active site 762376015473 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376015474 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376015475 active site 762376015476 catalytic site [active] 762376015477 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376015478 active site 2 [active] 762376015479 active site 1 [active] 762376015480 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376015481 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376015482 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376015483 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376015484 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376015485 active site 762376015486 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376015487 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376015488 CoA binding domain; Region: CoA_binding_2; pfam13380 762376015489 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762376015490 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762376015491 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376015492 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376015493 substrate binding site [chemical binding]; other site 762376015494 oxyanion hole (OAH) forming residues; other site 762376015495 trimer interface [polypeptide binding]; other site 762376015496 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 762376015497 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376015498 enoyl-CoA hydratase; Provisional; Region: PRK06495 762376015499 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376015500 substrate binding site [chemical binding]; other site 762376015501 oxyanion hole (OAH) forming residues; other site 762376015502 trimer interface [polypeptide binding]; other site 762376015503 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 762376015504 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 762376015505 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 762376015506 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 762376015507 Ligand binding site [chemical binding]; other site 762376015508 Electron transfer flavoprotein domain; Region: ETF; pfam01012 762376015509 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376015510 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376015511 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376015512 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376015513 active site 762376015514 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 762376015515 putative active site [active] 762376015516 putative catalytic site [active] 762376015517 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376015518 active site 2 [active] 762376015519 active site 1 [active] 762376015520 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 762376015521 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376015522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376015523 DNA-binding site [nucleotide binding]; DNA binding site 762376015524 UTRA domain; Region: UTRA; pfam07702 762376015525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376015526 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376015527 putative substrate translocation pore; other site 762376015528 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376015529 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 762376015530 classical (c) SDRs; Region: SDR_c; cd05233 762376015531 NAD(P) binding site [chemical binding]; other site 762376015532 active site 762376015533 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376015534 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 762376015535 NAD(P) binding site [chemical binding]; other site 762376015536 catalytic residues [active] 762376015537 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 762376015538 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 762376015539 FMN-binding pocket [chemical binding]; other site 762376015540 flavin binding motif; other site 762376015541 phosphate binding motif [ion binding]; other site 762376015542 beta-alpha-beta structure motif; other site 762376015543 NAD binding pocket [chemical binding]; other site 762376015544 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376015545 catalytic loop [active] 762376015546 iron binding site [ion binding]; other site 762376015547 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 762376015548 Cytochrome P450; Region: p450; cl12078 762376015549 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 762376015550 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 762376015551 Walker A/P-loop; other site 762376015552 ATP binding site [chemical binding]; other site 762376015553 Q-loop/lid; other site 762376015554 ABC transporter signature motif; other site 762376015555 Walker B; other site 762376015556 D-loop; other site 762376015557 H-loop/switch region; other site 762376015558 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 762376015559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015560 dimer interface [polypeptide binding]; other site 762376015561 conserved gate region; other site 762376015562 putative PBP binding loops; other site 762376015563 ABC-ATPase subunit interface; other site 762376015564 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 762376015565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015566 dimer interface [polypeptide binding]; other site 762376015567 conserved gate region; other site 762376015568 putative PBP binding loops; other site 762376015569 ABC-ATPase subunit interface; other site 762376015570 PBP superfamily domain; Region: PBP_like_2; cl17296 762376015571 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 762376015572 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 762376015573 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 762376015574 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 762376015575 putative active site [active] 762376015576 catalytic site [active] 762376015577 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 762376015578 putative domain interface [polypeptide binding]; other site 762376015579 putative active site [active] 762376015580 catalytic site [active] 762376015581 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 762376015582 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762376015583 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 762376015584 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 762376015585 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 762376015586 active site 762376015587 substrate binding site [chemical binding]; other site 762376015588 metal binding site [ion binding]; metal-binding site 762376015589 dihydropteroate synthase; Region: DHPS; TIGR01496 762376015590 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 762376015591 substrate binding pocket [chemical binding]; other site 762376015592 dimer interface [polypeptide binding]; other site 762376015593 inhibitor binding site; inhibition site 762376015594 FtsH Extracellular; Region: FtsH_ext; pfam06480 762376015595 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 762376015596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376015597 Walker A motif; other site 762376015598 ATP binding site [chemical binding]; other site 762376015599 Walker B motif; other site 762376015600 arginine finger; other site 762376015601 Peptidase family M41; Region: Peptidase_M41; pfam01434 762376015602 FtsJ-like methyltransferase; Region: FtsJ; cl17430 762376015603 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 762376015604 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 762376015605 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 762376015606 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 762376015607 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 762376015608 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 762376015609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376015610 dimerization interface [polypeptide binding]; other site 762376015611 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 762376015612 dimer interface [polypeptide binding]; other site 762376015613 putative CheW interface [polypeptide binding]; other site 762376015614 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 762376015615 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 762376015616 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 762376015617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015618 dimer interface [polypeptide binding]; other site 762376015619 conserved gate region; other site 762376015620 putative PBP binding loops; other site 762376015621 ABC-ATPase subunit interface; other site 762376015622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015623 dimer interface [polypeptide binding]; other site 762376015624 conserved gate region; other site 762376015625 putative PBP binding loops; other site 762376015626 ABC-ATPase subunit interface; other site 762376015627 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376015628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376015629 Walker A/P-loop; other site 762376015630 ATP binding site [chemical binding]; other site 762376015631 Q-loop/lid; other site 762376015632 ABC transporter signature motif; other site 762376015633 Walker B; other site 762376015634 D-loop; other site 762376015635 H-loop/switch region; other site 762376015636 TOBE domain; Region: TOBE_2; pfam08402 762376015637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376015638 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376015639 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376015640 dimerization interface [polypeptide binding]; other site 762376015641 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762376015642 catalytic core [active] 762376015643 short chain dehydrogenase; Provisional; Region: PRK07024 762376015644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376015645 NAD(P) binding site [chemical binding]; other site 762376015646 active site 762376015647 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 762376015648 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376015649 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 762376015650 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 762376015651 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376015652 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762376015653 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 762376015654 IMP binding site; other site 762376015655 dimer interface [polypeptide binding]; other site 762376015656 interdomain contacts; other site 762376015657 partial ornithine binding site; other site 762376015658 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 762376015659 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 762376015660 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 762376015661 catalytic site [active] 762376015662 subunit interface [polypeptide binding]; other site 762376015663 transaldolase-like protein; Provisional; Region: PTZ00411 762376015664 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 762376015665 active site 762376015666 dimer interface [polypeptide binding]; other site 762376015667 catalytic residue [active] 762376015668 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 762376015669 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762376015670 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376015671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015672 dimer interface [polypeptide binding]; other site 762376015673 conserved gate region; other site 762376015674 putative PBP binding loops; other site 762376015675 ABC-ATPase subunit interface; other site 762376015676 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376015677 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762376015678 Walker A/P-loop; other site 762376015679 ATP binding site [chemical binding]; other site 762376015680 Q-loop/lid; other site 762376015681 ABC transporter signature motif; other site 762376015682 Walker B; other site 762376015683 D-loop; other site 762376015684 H-loop/switch region; other site 762376015685 NMT1-like family; Region: NMT1_2; pfam13379 762376015686 NMT1/THI5 like; Region: NMT1; pfam09084 762376015687 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376015688 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376015689 recombination protein RecR; Reviewed; Region: recR; PRK00076 762376015690 RecR protein; Region: RecR; pfam02132 762376015691 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 762376015692 putative active site [active] 762376015693 putative metal-binding site [ion binding]; other site 762376015694 tetramer interface [polypeptide binding]; other site 762376015695 hypothetical protein; Validated; Region: PRK00153 762376015696 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 762376015697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376015698 Walker A motif; other site 762376015699 ATP binding site [chemical binding]; other site 762376015700 Walker B motif; other site 762376015701 arginine finger; other site 762376015702 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 762376015703 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 762376015704 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 762376015705 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 762376015706 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 762376015707 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 762376015708 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 762376015709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015710 ABC-ATPase subunit interface; other site 762376015711 putative PBP binding loops; other site 762376015712 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 762376015713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015714 dimer interface [polypeptide binding]; other site 762376015715 conserved gate region; other site 762376015716 putative PBP binding loops; other site 762376015717 ABC-ATPase subunit interface; other site 762376015718 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 762376015719 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 762376015720 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376015721 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 762376015722 Walker A/P-loop; other site 762376015723 ATP binding site [chemical binding]; other site 762376015724 Q-loop/lid; other site 762376015725 ABC transporter signature motif; other site 762376015726 Walker B; other site 762376015727 D-loop; other site 762376015728 H-loop/switch region; other site 762376015729 TOBE domain; Region: TOBE_2; pfam08402 762376015730 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376015731 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376015732 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376015733 Part of AAA domain; Region: AAA_19; pfam13245 762376015734 Family description; Region: UvrD_C_2; pfam13538 762376015735 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 762376015736 probable DNA repair protein; Region: TIGR03623 762376015737 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 762376015738 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 762376015739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376015740 putative substrate translocation pore; other site 762376015741 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 762376015742 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 762376015743 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 762376015744 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 762376015745 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 762376015746 NAD binding site [chemical binding]; other site 762376015747 substrate binding site [chemical binding]; other site 762376015748 catalytic Zn binding site [ion binding]; other site 762376015749 tetramer interface [polypeptide binding]; other site 762376015750 structural Zn binding site [ion binding]; other site 762376015751 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 762376015752 intracellular protease, PfpI family; Region: PfpI; TIGR01382 762376015753 conserved cys residue [active] 762376015754 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 762376015755 putative deacylase active site [active] 762376015756 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 762376015757 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376015758 active site 762376015759 DNA binding site [nucleotide binding] 762376015760 Int/Topo IB signature motif; other site 762376015761 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376015762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376015763 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015764 dimerization interface [polypeptide binding]; other site 762376015765 thiamine pyrophosphate protein; Validated; Region: PRK08199 762376015766 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376015767 PYR/PP interface [polypeptide binding]; other site 762376015768 dimer interface [polypeptide binding]; other site 762376015769 TPP binding site [chemical binding]; other site 762376015770 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376015771 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 762376015772 TPP-binding site [chemical binding]; other site 762376015773 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 762376015774 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376015775 FAD binding site [chemical binding]; other site 762376015776 substrate binding pocket [chemical binding]; other site 762376015777 catalytic base [active] 762376015778 SnoaL-like domain; Region: SnoaL_2; pfam12680 762376015779 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 762376015780 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 762376015781 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 762376015782 putative active site [active] 762376015783 putative catalytic site [active] 762376015784 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 762376015785 4Fe-4S binding domain; Region: Fer4; pfam00037 762376015786 4Fe-4S binding domain; Region: Fer4; pfam00037 762376015787 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 762376015788 dimerization interface [polypeptide binding]; other site 762376015789 FAD binding pocket [chemical binding]; other site 762376015790 FAD binding motif [chemical binding]; other site 762376015791 catalytic residues [active] 762376015792 NAD binding pocket [chemical binding]; other site 762376015793 phosphate binding motif [ion binding]; other site 762376015794 beta-alpha-beta structure motif; other site 762376015795 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 762376015796 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 762376015797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376015798 substrate binding site [chemical binding]; other site 762376015799 oxyanion hole (OAH) forming residues; other site 762376015800 trimer interface [polypeptide binding]; other site 762376015801 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 762376015802 oxyanion hole (OAH) forming residues; other site 762376015803 trimer interface [polypeptide binding]; other site 762376015804 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 762376015805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376015806 non-specific DNA binding site [nucleotide binding]; other site 762376015807 salt bridge; other site 762376015808 sequence-specific DNA binding site [nucleotide binding]; other site 762376015809 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 762376015810 ADP binding site [chemical binding]; other site 762376015811 magnesium binding site [ion binding]; other site 762376015812 putative shikimate binding site; other site 762376015813 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 762376015814 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376015815 acyl-activating enzyme (AAE) consensus motif; other site 762376015816 AMP binding site [chemical binding]; other site 762376015817 active site 762376015818 CoA binding site [chemical binding]; other site 762376015819 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376015820 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376015821 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 762376015822 putative ligand binding site [chemical binding]; other site 762376015823 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376015824 TM-ABC transporter signature motif; other site 762376015825 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376015826 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376015827 TM-ABC transporter signature motif; other site 762376015828 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376015829 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376015830 Walker A/P-loop; other site 762376015831 ATP binding site [chemical binding]; other site 762376015832 Q-loop/lid; other site 762376015833 ABC transporter signature motif; other site 762376015834 Walker B; other site 762376015835 D-loop; other site 762376015836 H-loop/switch region; other site 762376015837 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376015838 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376015839 Walker A/P-loop; other site 762376015840 ATP binding site [chemical binding]; other site 762376015841 Q-loop/lid; other site 762376015842 ABC transporter signature motif; other site 762376015843 Walker B; other site 762376015844 D-loop; other site 762376015845 H-loop/switch region; other site 762376015846 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376015847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376015848 Walker A/P-loop; other site 762376015849 ATP binding site [chemical binding]; other site 762376015850 Q-loop/lid; other site 762376015851 ABC transporter signature motif; other site 762376015852 Walker B; other site 762376015853 D-loop; other site 762376015854 H-loop/switch region; other site 762376015855 TOBE domain; Region: TOBE_2; pfam08402 762376015856 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 762376015857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015858 dimer interface [polypeptide binding]; other site 762376015859 conserved gate region; other site 762376015860 putative PBP binding loops; other site 762376015861 ABC-ATPase subunit interface; other site 762376015862 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 762376015863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015864 dimer interface [polypeptide binding]; other site 762376015865 conserved gate region; other site 762376015866 putative PBP binding loops; other site 762376015867 ABC-ATPase subunit interface; other site 762376015868 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 762376015869 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 762376015870 active site 762376015871 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 762376015872 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762376015873 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376015874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376015875 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015876 dimerization interface [polypeptide binding]; other site 762376015877 hypothetical protein; Validated; Region: PRK07586 762376015878 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376015879 PYR/PP interface [polypeptide binding]; other site 762376015880 dimer interface [polypeptide binding]; other site 762376015881 TPP binding site [chemical binding]; other site 762376015882 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 762376015883 TPP-binding site [chemical binding]; other site 762376015884 dimer interface [polypeptide binding]; other site 762376015885 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376015886 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376015887 Walker A/P-loop; other site 762376015888 ATP binding site [chemical binding]; other site 762376015889 Q-loop/lid; other site 762376015890 ABC transporter signature motif; other site 762376015891 Walker B; other site 762376015892 D-loop; other site 762376015893 H-loop/switch region; other site 762376015894 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376015895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015896 dimer interface [polypeptide binding]; other site 762376015897 conserved gate region; other site 762376015898 putative PBP binding loops; other site 762376015899 ABC-ATPase subunit interface; other site 762376015900 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376015901 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376015902 substrate binding pocket [chemical binding]; other site 762376015903 membrane-bound complex binding site; other site 762376015904 hinge residues; other site 762376015905 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 762376015906 agmatinase; Region: agmatinase; TIGR01230 762376015907 oligomer interface [polypeptide binding]; other site 762376015908 putative active site [active] 762376015909 Mn binding site [ion binding]; other site 762376015910 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376015911 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376015912 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376015913 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 762376015914 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376015915 substrate binding pocket [chemical binding]; other site 762376015916 membrane-bound complex binding site; other site 762376015917 hinge residues; other site 762376015918 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376015919 Coenzyme A transferase; Region: CoA_trans; cl17247 762376015920 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 762376015921 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 762376015922 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376015923 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376015924 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 762376015925 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 762376015926 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 762376015927 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762376015928 AIR carboxylase; Region: AIRC; pfam00731 762376015929 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 762376015930 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 762376015931 ATP binding site [chemical binding]; other site 762376015932 active site 762376015933 substrate binding site [chemical binding]; other site 762376015934 Uncharacterized conserved protein [Function unknown]; Region: COG3791 762376015935 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 762376015936 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 762376015937 intersubunit interface [polypeptide binding]; other site 762376015938 active site 762376015939 zinc binding site [ion binding]; other site 762376015940 Na+ binding site [ion binding]; other site 762376015941 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 762376015942 Strictosidine synthase; Region: Str_synth; pfam03088 762376015943 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 762376015944 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 762376015945 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376015946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 762376015947 MOSC domain; Region: MOSC; pfam03473 762376015948 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 762376015949 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376015950 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 762376015951 active site 762376015952 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 762376015953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376015954 Walker A/P-loop; other site 762376015955 ATP binding site [chemical binding]; other site 762376015956 Q-loop/lid; other site 762376015957 ABC transporter signature motif; other site 762376015958 Walker B; other site 762376015959 D-loop; other site 762376015960 H-loop/switch region; other site 762376015961 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 762376015962 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376015963 Walker A/P-loop; other site 762376015964 ATP binding site [chemical binding]; other site 762376015965 Q-loop/lid; other site 762376015966 ABC transporter signature motif; other site 762376015967 Walker B; other site 762376015968 D-loop; other site 762376015969 H-loop/switch region; other site 762376015970 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376015971 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 762376015972 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 762376015973 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 762376015974 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 762376015975 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 762376015976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376015977 DNA-binding site [nucleotide binding]; DNA binding site 762376015978 UTRA domain; Region: UTRA; pfam07702 762376015979 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376015980 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 762376015981 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376015982 active site 762376015983 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 762376015984 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 762376015985 AAA domain; Region: AAA_18; pfam13238 762376015986 active site 762376015987 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376015988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376015989 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376015990 dimerization interface [polypeptide binding]; other site 762376015991 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 762376015992 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376015993 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376015994 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 762376015995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376015996 dimer interface [polypeptide binding]; other site 762376015997 conserved gate region; other site 762376015998 ABC-ATPase subunit interface; other site 762376015999 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 762376016000 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 762376016001 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 762376016002 Walker A/P-loop; other site 762376016003 ATP binding site [chemical binding]; other site 762376016004 Q-loop/lid; other site 762376016005 ABC transporter signature motif; other site 762376016006 Walker B; other site 762376016007 D-loop; other site 762376016008 H-loop/switch region; other site 762376016009 Uncharacterized conserved protein [Function unknown]; Region: COG3791 762376016010 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376016011 dimerization interface [polypeptide binding]; other site 762376016012 putative DNA binding site [nucleotide binding]; other site 762376016013 putative Zn2+ binding site [ion binding]; other site 762376016014 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 762376016015 putative hydrophobic ligand binding site [chemical binding]; other site 762376016016 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 762376016017 rRNA binding site [nucleotide binding]; other site 762376016018 predicted 30S ribosome binding site; other site 762376016019 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 762376016020 Peptidase family M23; Region: Peptidase_M23; pfam01551 762376016021 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 762376016022 MPT binding site; other site 762376016023 trimer interface [polypeptide binding]; other site 762376016024 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 762376016025 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 762376016026 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 762376016027 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 762376016028 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 762376016029 catalytic residues [active] 762376016030 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376016031 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 762376016032 putative C-terminal domain interface [polypeptide binding]; other site 762376016033 putative GSH binding site (G-site) [chemical binding]; other site 762376016034 putative dimer interface [polypeptide binding]; other site 762376016035 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 762376016036 dimer interface [polypeptide binding]; other site 762376016037 N-terminal domain interface [polypeptide binding]; other site 762376016038 putative substrate binding pocket (H-site) [chemical binding]; other site 762376016039 AzlC protein; Region: AzlC; pfam03591 762376016040 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 762376016041 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 762376016042 HSP70 interaction site [polypeptide binding]; other site 762376016043 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 762376016044 substrate binding site [polypeptide binding]; other site 762376016045 dimer interface [polypeptide binding]; other site 762376016046 Cupin domain; Region: Cupin_2; cl17218 762376016047 glutathione S-transferase; Provisional; Region: PRK15113 762376016048 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 762376016049 C-terminal domain interface [polypeptide binding]; other site 762376016050 GSH binding site (G-site) [chemical binding]; other site 762376016051 dimer interface [polypeptide binding]; other site 762376016052 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 762376016053 substrate binding pocket (H-site) [chemical binding]; other site 762376016054 N-terminal domain interface [polypeptide binding]; other site 762376016055 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 762376016056 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376016057 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 762376016058 phosphate acetyltransferase; Provisional; Region: PRK11890 762376016059 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 762376016060 propionate/acetate kinase; Provisional; Region: PRK12379 762376016061 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 762376016062 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 762376016063 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 762376016064 NAD binding site [chemical binding]; other site 762376016065 homotetramer interface [polypeptide binding]; other site 762376016066 homodimer interface [polypeptide binding]; other site 762376016067 substrate binding site [chemical binding]; other site 762376016068 active site 762376016069 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 762376016070 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 762376016071 Sulfate transporter family; Region: Sulfate_transp; pfam00916 762376016072 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 762376016073 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 762376016074 Phosphoglycerate kinase; Region: PGK; pfam00162 762376016075 substrate binding site [chemical binding]; other site 762376016076 hinge regions; other site 762376016077 ADP binding site [chemical binding]; other site 762376016078 catalytic site [active] 762376016079 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 762376016080 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 762376016081 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 762376016082 transketolase; Reviewed; Region: PRK12753 762376016083 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 762376016084 TPP-binding site [chemical binding]; other site 762376016085 dimer interface [polypeptide binding]; other site 762376016086 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762376016087 PYR/PP interface [polypeptide binding]; other site 762376016088 dimer interface [polypeptide binding]; other site 762376016089 TPP binding site [chemical binding]; other site 762376016090 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376016091 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 762376016092 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 762376016093 putative RNAase interaction site [polypeptide binding]; other site 762376016094 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 762376016095 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 762376016096 active site 762376016097 nucleophile elbow; other site 762376016098 malic enzyme; Reviewed; Region: PRK12862 762376016099 Malic enzyme, N-terminal domain; Region: malic; pfam00390 762376016100 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 762376016101 putative NAD(P) binding site [chemical binding]; other site 762376016102 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 762376016103 aminotransferase; Validated; Region: PRK07337 762376016104 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376016105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376016106 homodimer interface [polypeptide binding]; other site 762376016107 catalytic residue [active] 762376016108 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 762376016109 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762376016110 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376016111 catalytic residue [active] 762376016112 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 762376016113 Abi-like protein; Region: Abi_2; pfam07751 762376016114 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 762376016115 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 762376016116 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 762376016117 [4Fe-4S] binding site [ion binding]; other site 762376016118 molybdopterin cofactor binding site; other site 762376016119 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 762376016120 molybdopterin cofactor binding site; other site 762376016121 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 762376016122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 762376016123 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376016124 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376016125 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762376016126 Walker A/P-loop; other site 762376016127 ATP binding site [chemical binding]; other site 762376016128 Q-loop/lid; other site 762376016129 ABC transporter signature motif; other site 762376016130 Walker B; other site 762376016131 D-loop; other site 762376016132 H-loop/switch region; other site 762376016133 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376016134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376016135 dimer interface [polypeptide binding]; other site 762376016136 conserved gate region; other site 762376016137 putative PBP binding loops; other site 762376016138 ABC-ATPase subunit interface; other site 762376016139 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 762376016140 NMT1-like family; Region: NMT1_2; pfam13379 762376016141 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 762376016142 ANTAR domain; Region: ANTAR; pfam03861 762376016143 siroheme synthase; Provisional; Region: cysG; PRK10637 762376016144 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 762376016145 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 762376016146 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 762376016147 active site 762376016148 SAM binding site [chemical binding]; other site 762376016149 homodimer interface [polypeptide binding]; other site 762376016150 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762376016151 active site 762376016152 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 762376016153 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 762376016154 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376016155 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376016156 putative ligand binding site [chemical binding]; other site 762376016157 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376016158 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376016159 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376016160 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 762376016161 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 762376016162 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 762376016163 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 762376016164 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376016165 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376016166 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 762376016167 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 762376016168 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376016169 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376016170 active site 762376016171 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376016172 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376016173 substrate binding site [chemical binding]; other site 762376016174 oxyanion hole (OAH) forming residues; other site 762376016175 trimer interface [polypeptide binding]; other site 762376016176 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 762376016177 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376016178 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762376016179 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 762376016180 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762376016181 carboxyltransferase (CT) interaction site; other site 762376016182 biotinylation site [posttranslational modification]; other site 762376016183 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 762376016184 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376016185 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376016186 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376016187 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 762376016188 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 762376016189 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 762376016190 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 762376016191 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 762376016192 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 762376016193 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 762376016194 Protein export membrane protein; Region: SecD_SecF; pfam02355 762376016195 putative transposase OrfB; Reviewed; Region: PHA02517 762376016196 HTH-like domain; Region: HTH_21; pfam13276 762376016197 Integrase core domain; Region: rve; pfam00665 762376016198 Integrase core domain; Region: rve_2; pfam13333 762376016199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376016200 Helix-turn-helix domain; Region: HTH_28; pfam13518 762376016201 Helix-turn-helix domain; Region: HTH_28; pfam13518 762376016202 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 762376016203 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 762376016204 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 762376016205 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 762376016206 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 762376016207 active site 762376016208 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 762376016209 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 762376016210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762376016211 FeS/SAM binding site; other site 762376016212 TRAM domain; Region: TRAM; pfam01938 762376016213 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 762376016214 PhoH-like protein; Region: PhoH; pfam02562 762376016215 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 762376016216 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 762376016217 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762376016218 Transporter associated domain; Region: CorC_HlyC; smart01091 762376016219 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 762376016220 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 762376016221 putative active site [active] 762376016222 catalytic triad [active] 762376016223 putative dimer interface [polypeptide binding]; other site 762376016224 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762376016225 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762376016226 active site 762376016227 catalytic tetrad [active] 762376016228 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 762376016229 PAS domain; Region: PAS_9; pfam13426 762376016230 PAS domain S-box; Region: sensory_box; TIGR00229 762376016231 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376016232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376016233 DNA binding residues [nucleotide binding] 762376016234 dimerization interface [polypeptide binding]; other site 762376016235 biotin synthase; Region: bioB; TIGR00433 762376016236 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762376016237 FeS/SAM binding site; other site 762376016238 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 762376016239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376016240 putative MFS family transporter protein; Provisional; Region: PRK03633 762376016241 putative substrate translocation pore; other site 762376016242 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 762376016243 catalytic triad [active] 762376016244 dimer interface [polypeptide binding]; other site 762376016245 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 762376016246 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 762376016247 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 762376016248 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 762376016249 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 762376016250 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 762376016251 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 762376016252 trimer interface [polypeptide binding]; other site 762376016253 dimer interface [polypeptide binding]; other site 762376016254 putative active site [active] 762376016255 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 762376016256 MoaE interaction surface [polypeptide binding]; other site 762376016257 MoeB interaction surface [polypeptide binding]; other site 762376016258 thiocarboxylated glycine; other site 762376016259 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 762376016260 MoaE homodimer interface [polypeptide binding]; other site 762376016261 MoaD interaction [polypeptide binding]; other site 762376016262 active site residues [active] 762376016263 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 762376016264 MPT binding site; other site 762376016265 trimer interface [polypeptide binding]; other site 762376016266 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 762376016267 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 762376016268 dimer interface [polypeptide binding]; other site 762376016269 putative functional site; other site 762376016270 putative MPT binding site; other site 762376016271 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 762376016272 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 762376016273 GTP binding site; other site 762376016274 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 762376016275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762376016276 FeS/SAM binding site; other site 762376016277 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 762376016278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016279 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 762376016280 PBP superfamily domain; Region: PBP_like; pfam12727 762376016281 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 762376016282 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 762376016283 putative dimer interface [polypeptide binding]; other site 762376016284 [2Fe-2S] cluster binding site [ion binding]; other site 762376016285 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 762376016286 putative dimer interface [polypeptide binding]; other site 762376016287 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 762376016288 SLBB domain; Region: SLBB; pfam10531 762376016289 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 762376016290 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 762376016291 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376016292 catalytic loop [active] 762376016293 iron binding site [ion binding]; other site 762376016294 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 762376016295 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 762376016296 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 762376016297 [4Fe-4S] binding site [ion binding]; other site 762376016298 molybdopterin cofactor binding site; other site 762376016299 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 762376016300 molybdopterin cofactor binding site; other site 762376016301 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 762376016302 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 762376016303 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376016304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376016305 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 762376016306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376016307 S-adenosylmethionine binding site [chemical binding]; other site 762376016308 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 762376016309 Chromate transporter; Region: Chromate_transp; pfam02417 762376016310 Chromate transporter; Region: Chromate_transp; pfam02417 762376016311 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376016312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376016313 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 762376016314 putative dimerization interface [polypeptide binding]; other site 762376016315 putative substrate binding pocket [chemical binding]; other site 762376016316 glutamate racemase; Provisional; Region: PRK00865 762376016317 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376016318 Ligand Binding Site [chemical binding]; other site 762376016319 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762376016320 Ligand Binding Site [chemical binding]; other site 762376016321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376016322 ATP binding site [chemical binding]; other site 762376016323 Mg2+ binding site [ion binding]; other site 762376016324 G-X-G motif; other site 762376016325 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376016326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376016327 active site 762376016328 phosphorylation site [posttranslational modification] 762376016329 intermolecular recognition site; other site 762376016330 dimerization interface [polypeptide binding]; other site 762376016331 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376016332 DNA binding site [nucleotide binding] 762376016333 Predicted membrane protein [Function unknown]; Region: COG3212 762376016334 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 762376016335 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 762376016336 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 762376016337 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 762376016338 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 762376016339 FAD binding pocket [chemical binding]; other site 762376016340 FAD binding motif [chemical binding]; other site 762376016341 phosphate binding motif [ion binding]; other site 762376016342 beta-alpha-beta structure motif; other site 762376016343 NAD binding pocket [chemical binding]; other site 762376016344 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 762376016345 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762376016346 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 762376016347 putative NAD(P) binding site [chemical binding]; other site 762376016348 putative active site [active] 762376016349 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 762376016350 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 762376016351 acyl-CoA synthetase; Validated; Region: PRK08162 762376016352 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 762376016353 acyl-activating enzyme (AAE) consensus motif; other site 762376016354 putative active site [active] 762376016355 AMP binding site [chemical binding]; other site 762376016356 putative CoA binding site [chemical binding]; other site 762376016357 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376016358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376016359 DNA-binding site [nucleotide binding]; DNA binding site 762376016360 UTRA domain; Region: UTRA; pfam07702 762376016361 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376016362 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 762376016363 putative ligand binding site [chemical binding]; other site 762376016364 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 762376016365 dinuclear metal binding motif [ion binding]; other site 762376016366 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376016367 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376016368 TM-ABC transporter signature motif; other site 762376016369 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376016370 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376016371 TM-ABC transporter signature motif; other site 762376016372 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376016373 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376016374 Walker A/P-loop; other site 762376016375 ATP binding site [chemical binding]; other site 762376016376 Q-loop/lid; other site 762376016377 ABC transporter signature motif; other site 762376016378 Walker B; other site 762376016379 D-loop; other site 762376016380 H-loop/switch region; other site 762376016381 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376016382 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376016383 Walker A/P-loop; other site 762376016384 ATP binding site [chemical binding]; other site 762376016385 Q-loop/lid; other site 762376016386 ABC transporter signature motif; other site 762376016387 Walker B; other site 762376016388 D-loop; other site 762376016389 H-loop/switch region; other site 762376016390 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 762376016391 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376016392 nucleophilic elbow; other site 762376016393 catalytic triad; other site 762376016394 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376016395 homotrimer interaction site [polypeptide binding]; other site 762376016396 putative active site [active] 762376016397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376016398 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376016399 NAD(P) binding site [chemical binding]; other site 762376016400 active site 762376016401 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376016402 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376016403 active site 762376016404 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 762376016405 Phosphotransferase enzyme family; Region: APH; pfam01636 762376016406 putative active site [active] 762376016407 putative substrate binding site [chemical binding]; other site 762376016408 ATP binding site [chemical binding]; other site 762376016409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762376016410 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 762376016411 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 762376016412 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 762376016413 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376016414 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376016415 DNA binding residues [nucleotide binding] 762376016416 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 762376016417 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376016418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376016419 DNA-binding site [nucleotide binding]; DNA binding site 762376016420 FCD domain; Region: FCD; pfam07729 762376016421 urea carboxylase; Region: urea_carbox; TIGR02712 762376016422 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376016423 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762376016424 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 762376016425 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 762376016426 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 762376016427 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762376016428 carboxyltransferase (CT) interaction site; other site 762376016429 biotinylation site [posttranslational modification]; other site 762376016430 allophanate hydrolase; Provisional; Region: PRK08186 762376016431 Amidase; Region: Amidase; pfam01425 762376016432 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376016433 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 762376016434 putative ligand binding site [chemical binding]; other site 762376016435 HEAT repeats; Region: HEAT_2; pfam13646 762376016436 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376016437 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376016438 TM-ABC transporter signature motif; other site 762376016439 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376016440 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376016441 TM-ABC transporter signature motif; other site 762376016442 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 762376016443 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376016444 Walker A/P-loop; other site 762376016445 ATP binding site [chemical binding]; other site 762376016446 Q-loop/lid; other site 762376016447 ABC transporter signature motif; other site 762376016448 Walker B; other site 762376016449 D-loop; other site 762376016450 H-loop/switch region; other site 762376016451 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 762376016452 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376016453 Walker A/P-loop; other site 762376016454 ATP binding site [chemical binding]; other site 762376016455 Q-loop/lid; other site 762376016456 ABC transporter signature motif; other site 762376016457 Walker B; other site 762376016458 D-loop; other site 762376016459 H-loop/switch region; other site 762376016460 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 762376016461 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376016462 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376016463 N-terminal plug; other site 762376016464 ligand-binding site [chemical binding]; other site 762376016465 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 762376016466 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 762376016467 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 762376016468 ArsC family; Region: ArsC; pfam03960 762376016469 catalytic residues [active] 762376016470 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 762376016471 active site 762376016472 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376016473 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 762376016474 tartrate dehydrogenase; Region: TTC; TIGR02089 762376016475 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 762376016476 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 762376016477 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762376016478 DNA binding site [nucleotide binding] 762376016479 active site 762376016480 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 762376016481 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 762376016482 AlkA N-terminal domain; Region: AlkA_N; pfam06029 762376016483 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 762376016484 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762376016485 minor groove reading motif; other site 762376016486 helix-hairpin-helix signature motif; other site 762376016487 substrate binding pocket [chemical binding]; other site 762376016488 active site 762376016489 transcriptional activator TtdR; Provisional; Region: PRK09801 762376016490 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376016491 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 762376016492 putative effector binding pocket; other site 762376016493 putative dimerization interface [polypeptide binding]; other site 762376016494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 762376016495 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 762376016496 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 762376016497 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762376016498 Walker A/P-loop; other site 762376016499 ATP binding site [chemical binding]; other site 762376016500 Q-loop/lid; other site 762376016501 ABC transporter signature motif; other site 762376016502 Walker B; other site 762376016503 D-loop; other site 762376016504 H-loop/switch region; other site 762376016505 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 762376016506 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762376016507 ABC-ATPase subunit interface; other site 762376016508 dimer interface [polypeptide binding]; other site 762376016509 putative PBP binding regions; other site 762376016510 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 762376016511 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 762376016512 putative hemin binding site; other site 762376016513 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 762376016514 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 762376016515 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 762376016516 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376016517 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 762376016518 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376016519 N-terminal plug; other site 762376016520 ligand-binding site [chemical binding]; other site 762376016521 fec operon regulator FecR; Reviewed; Region: PRK09774 762376016522 FecR protein; Region: FecR; pfam04773 762376016523 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376016524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376016525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376016526 DNA binding residues [nucleotide binding] 762376016527 Predicted integral membrane protein [Function unknown]; Region: COG5615 762376016528 Predicted transcriptional regulator [Transcription]; Region: COG2378 762376016529 HTH domain; Region: HTH_11; pfam08279 762376016530 WYL domain; Region: WYL; pfam13280 762376016531 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376016532 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 762376016533 putative dimer interface [polypeptide binding]; other site 762376016534 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 762376016535 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 762376016536 kynureninase; Region: kynureninase; TIGR01814 762376016537 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376016538 catalytic residue [active] 762376016539 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376016540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376016541 putative DNA binding site [nucleotide binding]; other site 762376016542 putative Zn2+ binding site [ion binding]; other site 762376016543 AsnC family; Region: AsnC_trans_reg; pfam01037 762376016544 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 762376016545 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 762376016546 putative active site pocket [active] 762376016547 cleavage site 762376016548 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762376016549 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376016550 substrate binding pocket [chemical binding]; other site 762376016551 membrane-bound complex binding site; other site 762376016552 hinge residues; other site 762376016553 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762376016554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376016555 dimer interface [polypeptide binding]; other site 762376016556 conserved gate region; other site 762376016557 putative PBP binding loops; other site 762376016558 ABC-ATPase subunit interface; other site 762376016559 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376016560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376016561 Walker A/P-loop; other site 762376016562 ATP binding site [chemical binding]; other site 762376016563 Q-loop/lid; other site 762376016564 ABC transporter signature motif; other site 762376016565 Walker B; other site 762376016566 D-loop; other site 762376016567 H-loop/switch region; other site 762376016568 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 762376016569 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376016570 N-terminal plug; other site 762376016571 ligand-binding site [chemical binding]; other site 762376016572 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762376016573 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 762376016574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376016575 Walker A/P-loop; other site 762376016576 ATP binding site [chemical binding]; other site 762376016577 Q-loop/lid; other site 762376016578 ABC transporter signature motif; other site 762376016579 Walker B; other site 762376016580 D-loop; other site 762376016581 H-loop/switch region; other site 762376016582 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 762376016583 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762376016584 ABC-ATPase subunit interface; other site 762376016585 dimer interface [polypeptide binding]; other site 762376016586 putative PBP binding regions; other site 762376016587 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 762376016588 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 762376016589 intersubunit interface [polypeptide binding]; other site 762376016590 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376016591 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376016592 ligand binding site [chemical binding]; other site 762376016593 flexible hinge region; other site 762376016594 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 762376016595 putative switch regulator; other site 762376016596 non-specific DNA interactions [nucleotide binding]; other site 762376016597 DNA binding site [nucleotide binding] 762376016598 sequence specific DNA binding site [nucleotide binding]; other site 762376016599 putative cAMP binding site [chemical binding]; other site 762376016600 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762376016601 Peptidase family M23; Region: Peptidase_M23; pfam01551 762376016602 MASE1; Region: MASE1; cl17823 762376016603 PAS fold; Region: PAS_3; pfam08447 762376016604 Esterase/lipase [General function prediction only]; Region: COG1647 762376016605 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 762376016606 CoA binding site [chemical binding]; other site 762376016607 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 762376016608 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 762376016609 Cu(I) binding site [ion binding]; other site 762376016610 Protein of unknown function (DUF461); Region: DUF461; pfam04314 762376016611 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376016612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376016613 ATP binding site [chemical binding]; other site 762376016614 G-X-G motif; other site 762376016615 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 762376016616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376016617 active site 762376016618 phosphorylation site [posttranslational modification] 762376016619 intermolecular recognition site; other site 762376016620 dimerization interface [polypeptide binding]; other site 762376016621 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762376016622 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 762376016623 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 762376016624 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 762376016625 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 762376016626 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 762376016627 D-pathway; other site 762376016628 Putative ubiquinol binding site [chemical binding]; other site 762376016629 Low-spin heme (heme b) binding site [chemical binding]; other site 762376016630 Putative water exit pathway; other site 762376016631 Binuclear center (heme o3/CuB) [ion binding]; other site 762376016632 K-pathway; other site 762376016633 Putative proton exit pathway; other site 762376016634 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 762376016635 Subunit I/III interface [polypeptide binding]; other site 762376016636 Subunit III/IV interface [polypeptide binding]; other site 762376016637 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 762376016638 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 762376016639 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 762376016640 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 762376016641 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 762376016642 NifQ; Region: NifQ; pfam04891 762376016643 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762376016644 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376016645 N-terminal plug; other site 762376016646 ligand-binding site [chemical binding]; other site 762376016647 SlyX; Region: SlyX; pfam04102 762376016648 malic enzyme; Reviewed; Region: PRK12861 762376016649 Malic enzyme, N-terminal domain; Region: malic; pfam00390 762376016650 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 762376016651 putative NAD(P) binding site [chemical binding]; other site 762376016652 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 762376016653 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376016654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376016655 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016656 dimerization interface [polypeptide binding]; other site 762376016657 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 762376016658 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376016659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376016660 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376016661 EamA-like transporter family; Region: EamA; pfam00892 762376016662 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376016663 MarR family; Region: MarR_2; pfam12802 762376016664 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 762376016665 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 762376016666 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376016668 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376016669 putative dimerization interface [polypeptide binding]; other site 762376016670 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376016671 short chain dehydrogenase; Provisional; Region: PRK06180 762376016672 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 762376016673 NADP binding site [chemical binding]; other site 762376016674 active site 762376016675 steroid binding site; other site 762376016676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376016677 Coenzyme A binding pocket [chemical binding]; other site 762376016678 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376016679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376016680 non-specific DNA binding site [nucleotide binding]; other site 762376016681 salt bridge; other site 762376016682 sequence-specific DNA binding site [nucleotide binding]; other site 762376016683 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 762376016684 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 762376016685 putative active site [active] 762376016686 catalytic site [active] 762376016687 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 762376016688 putative active site [active] 762376016689 catalytic site [active] 762376016690 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 762376016691 Uncharacterized conserved protein [Function unknown]; Region: COG1262 762376016692 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 762376016693 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 762376016694 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376016695 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 762376016696 short chain dehydrogenase; Provisional; Region: PRK06123 762376016697 classical (c) SDRs; Region: SDR_c; cd05233 762376016698 NAD(P) binding site [chemical binding]; other site 762376016699 active site 762376016700 MgtC family; Region: MgtC; pfam02308 762376016701 short chain dehydrogenase; Provisional; Region: PRK06125 762376016702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376016703 NAD(P) binding site [chemical binding]; other site 762376016704 active site 762376016705 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 762376016706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376016707 motif II; other site 762376016708 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762376016709 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376016710 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 762376016711 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 762376016712 DNA interaction; other site 762376016713 Metal-binding active site; metal-binding site 762376016714 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 762376016715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376016716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376016717 aconitate hydratase; Provisional; Region: acnA; PRK12881 762376016718 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 762376016719 substrate binding site [chemical binding]; other site 762376016720 ligand binding site [chemical binding]; other site 762376016721 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 762376016722 substrate binding site [chemical binding]; other site 762376016723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376016724 DNA-binding site [nucleotide binding]; DNA binding site 762376016725 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376016726 FCD domain; Region: FCD; pfam07729 762376016727 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376016728 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376016729 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376016730 N-terminal plug; other site 762376016731 ligand-binding site [chemical binding]; other site 762376016732 fec operon regulator FecR; Reviewed; Region: PRK09774 762376016733 FecR protein; Region: FecR; pfam04773 762376016734 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376016735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376016736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376016737 DNA binding residues [nucleotide binding] 762376016738 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376016739 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376016740 N-terminal plug; other site 762376016741 ligand-binding site [chemical binding]; other site 762376016742 fec operon regulator FecR; Reviewed; Region: PRK09774 762376016743 FecR protein; Region: FecR; pfam04773 762376016744 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376016745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376016746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376016747 DNA binding residues [nucleotide binding] 762376016748 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376016749 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376016750 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376016751 N-terminal plug; other site 762376016752 ligand-binding site [chemical binding]; other site 762376016753 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376016754 FecR protein; Region: FecR; pfam04773 762376016755 RNA polymerase sigma factor; Reviewed; Region: PRK12527 762376016756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376016757 DNA binding residues [nucleotide binding] 762376016758 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 762376016759 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 762376016760 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376016761 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 762376016762 SPFH domain / Band 7 family; Region: Band_7; pfam01145 762376016763 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 762376016764 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 762376016765 active site 762376016766 Zn binding site [ion binding]; other site 762376016767 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 762376016768 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376016769 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376016770 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 762376016771 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 762376016772 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376016773 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 762376016774 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376016775 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376016776 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 762376016777 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 762376016778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376016779 S-adenosylmethionine binding site [chemical binding]; other site 762376016780 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 762376016781 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 762376016782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376016783 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016784 dimerization interface [polypeptide binding]; other site 762376016785 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 762376016786 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 762376016787 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 762376016788 active site 762376016789 Zn binding site [ion binding]; other site 762376016790 cell density-dependent motility repressor; Provisional; Region: PRK10082 762376016791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376016792 LysR substrate binding domain; Region: LysR_substrate; pfam03466 762376016793 dimerization interface [polypeptide binding]; other site 762376016794 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 762376016795 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376016796 inhibitor-cofactor binding pocket; inhibition site 762376016797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376016798 catalytic residue [active] 762376016799 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 762376016800 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376016801 substrate binding pocket [chemical binding]; other site 762376016802 membrane-bound complex binding site; other site 762376016803 hinge residues; other site 762376016804 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376016805 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 762376016806 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 762376016807 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 762376016808 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 762376016809 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 762376016810 D-pathway; other site 762376016811 Putative ubiquinol binding site [chemical binding]; other site 762376016812 Low-spin heme (heme b) binding site [chemical binding]; other site 762376016813 Putative water exit pathway; other site 762376016814 Binuclear center (heme o3/CuB) [ion binding]; other site 762376016815 K-pathway; other site 762376016816 Putative proton exit pathway; other site 762376016817 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 762376016818 Subunit I/III interface [polypeptide binding]; other site 762376016819 Subunit III/IV interface [polypeptide binding]; other site 762376016820 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 762376016821 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 762376016822 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 762376016823 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 762376016824 trimer interface [polypeptide binding]; other site 762376016825 eyelet of channel; other site 762376016826 Putative ParB-like nuclease; Region: ParBc_2; cl17538 762376016827 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376016828 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376016829 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 762376016830 N-terminal domain interface [polypeptide binding]; other site 762376016831 HTH domain; Region: HTH_11; pfam08279 762376016832 WYL domain; Region: WYL; pfam13280 762376016833 transcriptional regulator RcsB; Provisional; Region: PRK10840 762376016834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376016835 active site 762376016836 phosphorylation site [posttranslational modification] 762376016837 intermolecular recognition site; other site 762376016838 dimerization interface [polypeptide binding]; other site 762376016839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376016840 DNA binding residues [nucleotide binding] 762376016841 dimerization interface [polypeptide binding]; other site 762376016842 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 762376016843 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 762376016844 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 762376016845 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376016846 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376016847 MarR family; Region: MarR_2; pfam12802 762376016848 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 762376016849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 762376016850 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762376016851 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762376016852 active site 762376016853 metal binding site [ion binding]; metal-binding site 762376016854 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376016855 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376016856 N-terminal plug; other site 762376016857 ligand-binding site [chemical binding]; other site 762376016858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 762376016859 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762376016860 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762376016861 active site 762376016862 catalytic tetrad [active] 762376016863 Mucin-like glycoprotein; Region: Mucin; pfam01456 762376016864 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376016865 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376016866 N-terminal plug; other site 762376016867 ligand-binding site [chemical binding]; other site 762376016868 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 762376016869 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762376016870 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376016871 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 762376016872 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762376016873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376016874 DNA-binding site [nucleotide binding]; DNA binding site 762376016875 UTRA domain; Region: UTRA; pfam07702 762376016876 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 762376016877 aldolase II superfamily protein; Provisional; Region: PRK07044 762376016878 intersubunit interface [polypeptide binding]; other site 762376016879 active site 762376016880 Zn2+ binding site [ion binding]; other site 762376016881 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 762376016882 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376016883 acyl-activating enzyme (AAE) consensus motif; other site 762376016884 AMP binding site [chemical binding]; other site 762376016885 active site 762376016886 CoA binding site [chemical binding]; other site 762376016887 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376016888 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376016889 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 762376016890 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376016891 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376016892 active site 762376016893 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376016894 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376016895 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376016896 active site 762376016897 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376016898 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 762376016899 substrate binding site [chemical binding]; other site 762376016900 oxyanion hole (OAH) forming residues; other site 762376016901 trimer interface [polypeptide binding]; other site 762376016902 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376016903 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376016904 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376016905 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 762376016906 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376016907 dimer interface [polypeptide binding]; other site 762376016908 active site 762376016909 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376016910 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376016912 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376016913 putative dimerization interface [polypeptide binding]; other site 762376016914 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376016915 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376016916 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376016917 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376016918 substrate binding site [chemical binding]; other site 762376016919 oxyanion hole (OAH) forming residues; other site 762376016920 trimer interface [polypeptide binding]; other site 762376016921 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376016923 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376016924 putative dimerization interface [polypeptide binding]; other site 762376016925 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376016926 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376016927 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376016928 thiolase; Provisional; Region: PRK06158 762376016929 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376016930 active site 762376016931 short chain dehydrogenase; Provisional; Region: PRK07791 762376016932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376016933 NAD(P) binding site [chemical binding]; other site 762376016934 active site 762376016935 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376016936 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376016937 active site 2 [active] 762376016938 active site 1 [active] 762376016939 Coenzyme A transferase; Region: CoA_trans; cl17247 762376016940 Coenzyme A transferase; Region: CoA_trans; cl17247 762376016941 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376016942 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376016943 active site 762376016944 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376016945 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376016946 active site 762376016947 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376016948 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762376016949 tetramerization interface [polypeptide binding]; other site 762376016950 NAD(P) binding site [chemical binding]; other site 762376016951 catalytic residues [active] 762376016952 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376016953 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762376016954 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376016955 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376016956 acetyl-CoA acetyltransferase; Provisional; Region: PRK12578 762376016957 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376016958 active site 762376016959 LysE type translocator; Region: LysE; cl00565 762376016960 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 762376016961 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 762376016962 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 762376016963 DsrE/DsrF-like family; Region: DrsE; cl00672 762376016964 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 762376016965 active site 762376016966 metal binding site [ion binding]; metal-binding site 762376016967 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 762376016968 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762376016969 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 762376016970 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762376016971 catalytic residues [active] 762376016972 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 762376016973 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 762376016974 Predicted secreted protein [Function unknown]; Region: COG5501 762376016975 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 762376016976 Cytochrome c; Region: Cytochrom_C; pfam00034 762376016977 Cytochrome c551/c552 [Energy production and conversion]; Region: COG4654 762376016978 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 762376016979 Moco binding site; other site 762376016980 metal coordination site [ion binding]; other site 762376016981 dimerization interface [polypeptide binding]; other site 762376016982 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 762376016983 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 762376016984 Cytochrome c; Region: Cytochrom_C; cl11414 762376016985 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376016986 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762376016987 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762376016988 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 762376016989 active site 762376016990 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376016991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376016992 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376016993 dimerization interface [polypeptide binding]; other site 762376016994 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376016995 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 762376016996 substrate binding site [chemical binding]; other site 762376016997 active site 762376016998 catalytic residues [active] 762376016999 heterodimer interface [polypeptide binding]; other site 762376017000 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 762376017001 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 762376017002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376017003 catalytic residue [active] 762376017004 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376017005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017006 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017007 dimerization interface [polypeptide binding]; other site 762376017008 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 762376017009 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 762376017010 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 762376017011 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376017012 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376017013 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376017014 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376017015 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376017016 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 762376017017 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762376017018 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 762376017019 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 762376017020 LytTr DNA-binding domain; Region: LytTR; smart00850 762376017021 Beta-lactamase; Region: Beta-lactamase; cl17358 762376017022 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 762376017023 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 762376017024 Beta-lactamase; Region: Beta-lactamase; pfam00144 762376017025 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 762376017026 Autotransporter beta-domain; Region: Autotransporter; pfam03797 762376017027 Methyltransferase domain; Region: Methyltransf_23; pfam13489 762376017028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376017029 S-adenosylmethionine binding site [chemical binding]; other site 762376017030 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 762376017031 XFP N-terminal domain; Region: XFP_N; pfam09364 762376017032 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 762376017033 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762376017034 Beta-Casp domain; Region: Beta-Casp; smart01027 762376017035 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 762376017036 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376017037 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376017038 N-terminal plug; other site 762376017039 ligand-binding site [chemical binding]; other site 762376017040 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 762376017041 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 762376017042 putative ligand binding residues [chemical binding]; other site 762376017043 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 762376017044 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 762376017045 Walker A/P-loop; other site 762376017046 ATP binding site [chemical binding]; other site 762376017047 Q-loop/lid; other site 762376017048 ABC transporter signature motif; other site 762376017049 Walker B; other site 762376017050 D-loop; other site 762376017051 H-loop/switch region; other site 762376017052 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762376017053 ABC-ATPase subunit interface; other site 762376017054 dimer interface [polypeptide binding]; other site 762376017055 putative PBP binding regions; other site 762376017056 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 762376017057 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762376017058 ABC-ATPase subunit interface; other site 762376017059 dimer interface [polypeptide binding]; other site 762376017060 putative PBP binding regions; other site 762376017061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376017062 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762376017063 Walker A/P-loop; other site 762376017064 ATP binding site [chemical binding]; other site 762376017065 Q-loop/lid; other site 762376017066 ABC transporter signature motif; other site 762376017067 Walker B; other site 762376017068 D-loop; other site 762376017069 H-loop/switch region; other site 762376017070 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762376017071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376017072 Walker A/P-loop; other site 762376017073 ATP binding site [chemical binding]; other site 762376017074 Q-loop/lid; other site 762376017075 ABC transporter signature motif; other site 762376017076 Walker B; other site 762376017077 D-loop; other site 762376017078 H-loop/switch region; other site 762376017079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376017080 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 762376017081 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376017082 C-terminal domain interface [polypeptide binding]; other site 762376017083 GSH binding site (G-site) [chemical binding]; other site 762376017084 dimer interface [polypeptide binding]; other site 762376017085 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 762376017086 dimer interface [polypeptide binding]; other site 762376017087 N-terminal domain interface [polypeptide binding]; other site 762376017088 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 762376017089 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 762376017090 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376017091 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 762376017092 C-terminal domain interface [polypeptide binding]; other site 762376017093 GSH binding site (G-site) [chemical binding]; other site 762376017094 dimer interface [polypeptide binding]; other site 762376017095 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 762376017096 N-terminal domain interface [polypeptide binding]; other site 762376017097 dimer interface [polypeptide binding]; other site 762376017098 substrate binding pocket (H-site) [chemical binding]; other site 762376017099 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 762376017100 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 762376017101 active site 762376017102 oxalacetate binding site [chemical binding]; other site 762376017103 citrylCoA binding site [chemical binding]; other site 762376017104 coenzyme A binding site [chemical binding]; other site 762376017105 catalytic triad [active] 762376017106 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 762376017107 CoA binding domain; Region: CoA_binding_2; pfam13380 762376017108 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762376017109 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762376017110 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376017111 active site 2 [active] 762376017112 active site 1 [active] 762376017113 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376017114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376017115 NAD(P) binding site [chemical binding]; other site 762376017116 active site 762376017117 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376017118 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376017119 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 762376017120 NAD(P) binding site [chemical binding]; other site 762376017121 catalytic residues [active] 762376017122 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 762376017123 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 762376017124 active site 762376017125 NAD binding site [chemical binding]; other site 762376017126 metal binding site [ion binding]; metal-binding site 762376017127 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376017128 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 762376017129 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 762376017130 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 762376017131 FMN binding site [chemical binding]; other site 762376017132 substrate binding site [chemical binding]; other site 762376017133 putative catalytic residue [active] 762376017134 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376017135 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376017136 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376017137 active site 762376017138 RNA polymerase sigma factor; Reviewed; Region: PRK12527 762376017139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376017140 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376017141 DNA binding residues [nucleotide binding] 762376017142 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376017143 FecR protein; Region: FecR; pfam04773 762376017144 Secretin and TonB N terminus short domain; Region: STN; pfam07660 762376017145 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376017146 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376017147 N-terminal plug; other site 762376017148 ligand-binding site [chemical binding]; other site 762376017149 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 762376017150 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762376017151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376017152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376017153 Putative cyclase; Region: Cyclase; pfam04199 762376017154 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376017155 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017157 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376017158 putative effector binding pocket; other site 762376017159 dimerization interface [polypeptide binding]; other site 762376017160 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376017161 MarR family; Region: MarR; pfam01047 762376017162 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 762376017163 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 762376017164 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 762376017165 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762376017166 catalytic residues [active] 762376017167 Uncharacterized secreted protein [Function unknown]; Region: COG5430 762376017168 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 762376017169 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 762376017170 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 762376017171 PapC N-terminal domain; Region: PapC_N; pfam13954 762376017172 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 762376017173 PapC C-terminal domain; Region: PapC_C; pfam13953 762376017174 Spore Coat Protein U domain; Region: SCPU; cl02253 762376017175 Spore Coat Protein U domain; Region: SCPU; pfam05229 762376017176 putative mechanosensitive channel protein; Provisional; Region: PRK11465 762376017177 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762376017178 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376017179 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376017180 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 762376017181 dimer interface [polypeptide binding]; other site 762376017182 N-terminal domain interface [polypeptide binding]; other site 762376017183 substrate binding pocket (H-site) [chemical binding]; other site 762376017184 Predicted transcriptional regulators [Transcription]; Region: COG1733 762376017185 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762376017186 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 762376017187 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 762376017188 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 762376017189 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 762376017190 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 762376017191 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 762376017192 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 762376017193 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376017194 N-terminal plug; other site 762376017195 ligand-binding site [chemical binding]; other site 762376017196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017197 LysR substrate binding domain; Region: LysR_substrate; pfam03466 762376017198 dimerization interface [polypeptide binding]; other site 762376017199 acetylornithine deacetylase; Provisional; Region: PRK07522 762376017200 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 762376017201 metal binding site [ion binding]; metal-binding site 762376017202 putative dimer interface [polypeptide binding]; other site 762376017203 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376017204 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 762376017205 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762376017206 PYR/PP interface [polypeptide binding]; other site 762376017207 dimer interface [polypeptide binding]; other site 762376017208 TPP binding site [chemical binding]; other site 762376017209 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762376017210 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 762376017211 TPP-binding site [chemical binding]; other site 762376017212 aspartate aminotransferase; Provisional; Region: PRK05764 762376017213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376017214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376017215 homodimer interface [polypeptide binding]; other site 762376017216 catalytic residue [active] 762376017217 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376017220 dimerization interface [polypeptide binding]; other site 762376017221 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376017222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376017223 DNA-binding site [nucleotide binding]; DNA binding site 762376017224 FCD domain; Region: FCD; pfam07729 762376017225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376017226 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376017227 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376017228 MlrC C-terminus; Region: MlrC_C; pfam07171 762376017229 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 762376017230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376017231 catalytic residue [active] 762376017232 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376017233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376017234 Walker A/P-loop; other site 762376017235 ATP binding site [chemical binding]; other site 762376017236 Q-loop/lid; other site 762376017237 ABC transporter signature motif; other site 762376017238 Walker B; other site 762376017239 D-loop; other site 762376017240 H-loop/switch region; other site 762376017241 TOBE domain; Region: TOBE_2; pfam08402 762376017242 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 762376017243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376017244 dimer interface [polypeptide binding]; other site 762376017245 conserved gate region; other site 762376017246 ABC-ATPase subunit interface; other site 762376017247 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 762376017248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376017249 dimer interface [polypeptide binding]; other site 762376017250 conserved gate region; other site 762376017251 putative PBP binding loops; other site 762376017252 ABC-ATPase subunit interface; other site 762376017253 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 762376017254 active site 762376017255 Mn binding site [ion binding]; other site 762376017256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376017257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376017258 putative substrate translocation pore; other site 762376017259 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376017260 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376017261 metal binding site [ion binding]; metal-binding site 762376017262 active site 762376017263 I-site; other site 762376017264 EamA-like transporter family; Region: EamA; pfam00892 762376017265 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762376017266 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762376017267 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 762376017268 Predicted transcriptional regulator [Transcription]; Region: COG1959 762376017269 Transcriptional regulator; Region: Rrf2; pfam02082 762376017270 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376017271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376017272 putative substrate translocation pore; other site 762376017273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376017274 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017276 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 762376017277 putative effector binding pocket; other site 762376017278 putative dimerization interface [polypeptide binding]; other site 762376017279 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 762376017280 oligomerisation interface [polypeptide binding]; other site 762376017281 mobile loop; other site 762376017282 roof hairpin; other site 762376017283 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 762376017284 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 762376017285 ring oligomerisation interface [polypeptide binding]; other site 762376017286 ATP/Mg binding site [chemical binding]; other site 762376017287 stacking interactions; other site 762376017288 hinge regions; other site 762376017289 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 762376017290 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376017291 MarR family; Region: MarR_2; pfam12802 762376017292 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376017293 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376017294 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762376017295 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762376017296 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 762376017297 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 762376017298 NAD binding site [chemical binding]; other site 762376017299 catalytic residues [active] 762376017300 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376017301 homotrimer interaction site [polypeptide binding]; other site 762376017302 putative active site [active] 762376017303 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376017304 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017305 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017306 dimerization interface [polypeptide binding]; other site 762376017307 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 762376017308 Amidohydrolase; Region: Amidohydro_2; pfam04909 762376017309 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 762376017310 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 762376017311 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 762376017312 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 762376017313 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 762376017314 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 762376017315 putative active site pocket [active] 762376017316 putative metal binding site [ion binding]; other site 762376017317 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 762376017318 galactarate dehydratase; Region: galactar-dH20; TIGR03248 762376017319 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 762376017320 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376017321 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376017322 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 762376017323 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 762376017324 NAD binding site [chemical binding]; other site 762376017325 homotetramer interface [polypeptide binding]; other site 762376017326 homodimer interface [polypeptide binding]; other site 762376017327 active site 762376017328 DctM-like transporters; Region: DctM; pfam06808 762376017329 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 762376017330 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 762376017331 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 762376017332 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 762376017333 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 762376017334 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 762376017335 putative NAD(P) binding site [chemical binding]; other site 762376017336 catalytic Zn binding site [ion binding]; other site 762376017337 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376017338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376017339 DNA-binding site [nucleotide binding]; DNA binding site 762376017340 FCD domain; Region: FCD; pfam07729 762376017341 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 762376017342 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 762376017343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376017344 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 762376017345 active site 762376017346 dimer interface [polypeptide binding]; other site 762376017347 Competence-damaged protein; Region: CinA; pfam02464 762376017348 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 762376017349 tetramer interfaces [polypeptide binding]; other site 762376017350 binuclear metal-binding site [ion binding]; other site 762376017351 thiamine monophosphate kinase; Provisional; Region: PRK05731 762376017352 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 762376017353 ATP binding site [chemical binding]; other site 762376017354 dimerization interface [polypeptide binding]; other site 762376017355 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 762376017356 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 762376017357 homopentamer interface [polypeptide binding]; other site 762376017358 active site 762376017359 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 762376017360 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 762376017361 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 762376017362 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 762376017363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 762376017364 motif II; other site 762376017365 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376017366 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376017367 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376017368 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 762376017369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376017370 substrate binding pocket [chemical binding]; other site 762376017371 membrane-bound complex binding site; other site 762376017372 hinge residues; other site 762376017373 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 762376017374 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 762376017375 Walker A/P-loop; other site 762376017376 ATP binding site [chemical binding]; other site 762376017377 Q-loop/lid; other site 762376017378 ABC transporter signature motif; other site 762376017379 Walker B; other site 762376017380 D-loop; other site 762376017381 H-loop/switch region; other site 762376017382 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 762376017383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376017384 dimer interface [polypeptide binding]; other site 762376017385 conserved gate region; other site 762376017386 ABC-ATPase subunit interface; other site 762376017387 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 762376017388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376017389 dimer interface [polypeptide binding]; other site 762376017390 conserved gate region; other site 762376017391 ABC-ATPase subunit interface; other site 762376017392 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 762376017393 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376017394 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376017395 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376017396 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376017397 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 762376017398 Autotransporter beta-domain; Region: Autotransporter; pfam03797 762376017399 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 762376017400 putative active site [active] 762376017401 putative metal binding residues [ion binding]; other site 762376017402 signature motif; other site 762376017403 putative triphosphate binding site [ion binding]; other site 762376017404 CHAD domain; Region: CHAD; pfam05235 762376017405 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 762376017406 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 762376017407 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762376017408 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 762376017409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376017410 S-adenosylmethionine binding site [chemical binding]; other site 762376017411 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 762376017412 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 762376017413 active site 762376017414 (T/H)XGH motif; other site 762376017415 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 762376017416 Benzoate membrane transport protein; Region: BenE; pfam03594 762376017417 benzoate transporter; Region: benE; TIGR00843 762376017418 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 762376017419 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 762376017420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376017421 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376017422 putative substrate translocation pore; other site 762376017423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376017424 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762376017425 MarR family; Region: MarR; pfam01047 762376017426 MarR family; Region: MarR_2; cl17246 762376017427 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376017428 Src Homology 3 domain superfamily; Region: SH3; cl17036 762376017429 Src Homology 3 domain superfamily; Region: SH3; cl17036 762376017430 peptide ligand binding site [polypeptide binding]; other site 762376017431 GTP-binding protein YchF; Reviewed; Region: PRK09601 762376017432 YchF GTPase; Region: YchF; cd01900 762376017433 G1 box; other site 762376017434 GTP/Mg2+ binding site [chemical binding]; other site 762376017435 Switch I region; other site 762376017436 G2 box; other site 762376017437 Switch II region; other site 762376017438 G3 box; other site 762376017439 G4 box; other site 762376017440 G5 box; other site 762376017441 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 762376017442 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 762376017443 putative active site [active] 762376017444 catalytic residue [active] 762376017445 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 762376017446 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 762376017447 5S rRNA interface [nucleotide binding]; other site 762376017448 CTC domain interface [polypeptide binding]; other site 762376017449 L16 interface [polypeptide binding]; other site 762376017450 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 762376017451 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 762376017452 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762376017453 active site 762376017454 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Region: ispE; TIGR00154 762376017455 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 762376017456 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 762376017457 TPR repeat; Region: TPR_11; pfam13414 762376017458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762376017459 binding surface 762376017460 TPR motif; other site 762376017461 TPR repeat; Region: TPR_11; pfam13414 762376017462 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 762376017463 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 762376017464 DNA binding site [nucleotide binding] 762376017465 catalytic residue [active] 762376017466 H2TH interface [polypeptide binding]; other site 762376017467 putative catalytic residues [active] 762376017468 turnover-facilitating residue; other site 762376017469 intercalation triad [nucleotide binding]; other site 762376017470 8OG recognition residue [nucleotide binding]; other site 762376017471 putative reading head residues; other site 762376017472 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 762376017473 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 762376017474 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762376017475 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 762376017476 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 762376017477 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 762376017478 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017480 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 762376017481 substrate binding pocket [chemical binding]; other site 762376017482 dimerization interface [polypeptide binding]; other site 762376017483 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 762376017484 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 762376017485 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 762376017486 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376017487 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 762376017488 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 762376017489 putative acyl-acceptor binding pocket; other site 762376017490 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 762376017491 Sulfatase; Region: Sulfatase; pfam00884 762376017492 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376017493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376017494 DNA-binding site [nucleotide binding]; DNA binding site 762376017495 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376017496 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 762376017497 active site 762376017498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376017499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 762376017500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376017501 dimer interface [polypeptide binding]; other site 762376017502 phosphorylation site [posttranslational modification] 762376017503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376017504 ATP binding site [chemical binding]; other site 762376017505 Mg2+ binding site [ion binding]; other site 762376017506 G-X-G motif; other site 762376017507 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376017508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376017509 active site 762376017510 phosphorylation site [posttranslational modification] 762376017511 intermolecular recognition site; other site 762376017512 dimerization interface [polypeptide binding]; other site 762376017513 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376017514 DNA binding site [nucleotide binding] 762376017515 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376017516 FAD binding domain; Region: FAD_binding_4; pfam01565 762376017517 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762376017518 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 762376017519 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 762376017520 active site 762376017521 substrate binding site [chemical binding]; other site 762376017522 metal binding site [ion binding]; metal-binding site 762376017523 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 762376017524 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 762376017525 active site 762376017526 dimer interface [polypeptide binding]; other site 762376017527 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 762376017528 dimer interface [polypeptide binding]; other site 762376017529 active site 762376017530 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 762376017531 putative ADP-binding pocket [chemical binding]; other site 762376017532 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376017533 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 762376017534 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 762376017535 putative ADP-binding pocket [chemical binding]; other site 762376017536 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376017537 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 762376017538 putative ADP-binding pocket [chemical binding]; other site 762376017539 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 762376017540 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 762376017541 active site 762376017542 dimer interface [polypeptide binding]; other site 762376017543 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 762376017544 Ligand Binding Site [chemical binding]; other site 762376017545 Molecular Tunnel; other site 762376017546 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376017547 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 762376017548 putative ADP-binding pocket [chemical binding]; other site 762376017549 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 762376017550 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 762376017551 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 762376017552 NAD binding site [chemical binding]; other site 762376017553 substrate binding site [chemical binding]; other site 762376017554 homodimer interface [polypeptide binding]; other site 762376017555 active site 762376017556 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 762376017557 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 762376017558 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 762376017559 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 762376017560 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 762376017561 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 762376017562 Mg++ binding site [ion binding]; other site 762376017563 putative catalytic motif [active] 762376017564 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 762376017565 diiron binding motif [ion binding]; other site 762376017566 OsmC-like protein; Region: OsmC; cl00767 762376017567 thymidylate synthase; Provisional; Region: thyA; PRK13821 762376017568 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 762376017569 dimerization interface [polypeptide binding]; other site 762376017570 active site 762376017571 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 762376017572 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 762376017573 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376017574 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376017575 metal binding site [ion binding]; metal-binding site 762376017576 active site 762376017577 I-site; other site 762376017578 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376017579 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 762376017580 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 762376017581 folate binding site [chemical binding]; other site 762376017582 NADP+ binding site [chemical binding]; other site 762376017583 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376017584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376017585 DNA-binding site [nucleotide binding]; DNA binding site 762376017586 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376017587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376017588 homodimer interface [polypeptide binding]; other site 762376017589 catalytic residue [active] 762376017590 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 762376017591 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376017592 inhibitor-cofactor binding pocket; inhibition site 762376017593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376017594 catalytic residue [active] 762376017595 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 762376017596 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 762376017597 tetrameric interface [polypeptide binding]; other site 762376017598 NAD binding site [chemical binding]; other site 762376017599 catalytic residues [active] 762376017600 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376017601 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376017602 MlrC C-terminus; Region: MlrC_C; pfam07171 762376017603 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 762376017604 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762376017605 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376017606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376017607 dimer interface [polypeptide binding]; other site 762376017608 conserved gate region; other site 762376017609 putative PBP binding loops; other site 762376017610 ABC-ATPase subunit interface; other site 762376017611 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 762376017612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376017613 dimer interface [polypeptide binding]; other site 762376017614 conserved gate region; other site 762376017615 putative PBP binding loops; other site 762376017616 ABC-ATPase subunit interface; other site 762376017617 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376017618 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376017619 Walker A/P-loop; other site 762376017620 ATP binding site [chemical binding]; other site 762376017621 Q-loop/lid; other site 762376017622 ABC transporter signature motif; other site 762376017623 Walker B; other site 762376017624 D-loop; other site 762376017625 H-loop/switch region; other site 762376017626 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376017627 Walker A/P-loop; other site 762376017628 ATP binding site [chemical binding]; other site 762376017629 Q-loop/lid; other site 762376017630 ABC transporter signature motif; other site 762376017631 Walker B; other site 762376017632 D-loop; other site 762376017633 H-loop/switch region; other site 762376017634 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762376017635 amidase; Provisional; Region: PRK07042 762376017636 Amidase; Region: Amidase; cl11426 762376017637 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376017638 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376017639 MlrC C-terminus; Region: MlrC_C; pfam07171 762376017640 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 762376017641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 762376017642 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 762376017643 glycine dehydrogenase; Provisional; Region: PRK05367 762376017644 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 762376017645 tetramer interface [polypeptide binding]; other site 762376017646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376017647 catalytic residue [active] 762376017648 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 762376017649 tetramer interface [polypeptide binding]; other site 762376017650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376017651 catalytic residue [active] 762376017652 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 762376017653 lipoyl attachment site [posttranslational modification]; other site 762376017654 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 762376017655 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 762376017656 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 762376017657 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 762376017658 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 762376017659 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 762376017660 Predicted flavoproteins [General function prediction only]; Region: COG2081 762376017661 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 762376017662 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 762376017663 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376017664 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376017665 catalytic residue [active] 762376017666 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 762376017667 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762376017668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376017669 Coenzyme A binding pocket [chemical binding]; other site 762376017670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762376017671 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376017672 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376017673 metal binding site [ion binding]; metal-binding site 762376017674 active site 762376017675 I-site; other site 762376017676 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762376017677 active site 762376017678 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762376017679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376017680 Coenzyme A binding pocket [chemical binding]; other site 762376017681 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 762376017682 trimer interface [polypeptide binding]; other site 762376017683 active site 762376017684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 762376017685 Family of unknown function (DUF490); Region: DUF490; pfam04357 762376017686 Surface antigen; Region: Bac_surface_Ag; pfam01103 762376017687 Domain of unknown function DUF59; Region: DUF59; pfam01883 762376017688 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 762376017689 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 762376017690 Walker A motif; other site 762376017691 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 762376017692 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 762376017693 active site 762376017694 HIGH motif; other site 762376017695 KMSKS motif; other site 762376017696 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 762376017697 tRNA binding surface [nucleotide binding]; other site 762376017698 anticodon binding site; other site 762376017699 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 762376017700 dimer interface [polypeptide binding]; other site 762376017701 putative tRNA-binding site [nucleotide binding]; other site 762376017702 rhodanese superfamily protein; Provisional; Region: PRK05320 762376017703 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376017704 active site residue [active] 762376017705 META domain; Region: META; pfam03724 762376017706 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 762376017707 META domain; Region: META; pfam03724 762376017708 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 762376017709 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376017710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376017711 sequence-specific DNA binding site [nucleotide binding]; other site 762376017712 salt bridge; other site 762376017713 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376017714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376017715 phosphorylation site [posttranslational modification] 762376017716 intermolecular recognition site; other site 762376017717 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 762376017718 DNA binding site [nucleotide binding] 762376017719 voltage-gated potassium channel; Provisional; Region: PRK10537 762376017720 Ion channel; Region: Ion_trans_2; pfam07885 762376017721 TrkA-N domain; Region: TrkA_N; pfam02254 762376017722 phage resistance protein; Provisional; Region: PRK10551 762376017723 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 762376017724 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376017725 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376017726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376017727 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 762376017728 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 762376017729 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 762376017730 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376017731 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762376017732 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762376017733 Walker A/P-loop; other site 762376017734 ATP binding site [chemical binding]; other site 762376017735 Q-loop/lid; other site 762376017736 ABC transporter signature motif; other site 762376017737 Walker B; other site 762376017738 D-loop; other site 762376017739 H-loop/switch region; other site 762376017740 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762376017741 Walker A/P-loop; other site 762376017742 ATP binding site [chemical binding]; other site 762376017743 Q-loop/lid; other site 762376017744 ABC transporter signature motif; other site 762376017745 Walker B; other site 762376017746 D-loop; other site 762376017747 H-loop/switch region; other site 762376017748 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 762376017749 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 762376017750 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762376017751 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 762376017752 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 762376017753 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 762376017754 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 762376017755 NAD(P) binding site [chemical binding]; other site 762376017756 homotetramer interface [polypeptide binding]; other site 762376017757 homodimer interface [polypeptide binding]; other site 762376017758 active site 762376017759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017760 LysR family transcriptional regulator; Provisional; Region: PRK14997 762376017761 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376017762 putative effector binding pocket; other site 762376017763 dimerization interface [polypeptide binding]; other site 762376017764 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 762376017765 dimer interface [polypeptide binding]; other site 762376017766 FMN binding site [chemical binding]; other site 762376017767 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376017768 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 762376017769 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 762376017770 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 762376017771 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 762376017772 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376017773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376017774 DNA-binding site [nucleotide binding]; DNA binding site 762376017775 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376017776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376017777 homodimer interface [polypeptide binding]; other site 762376017778 catalytic residue [active] 762376017779 RNA polymerase sigma factor; Provisional; Region: PRK12528 762376017780 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376017781 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 762376017782 DNA binding residues [nucleotide binding] 762376017783 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376017784 FecR protein; Region: FecR; pfam04773 762376017785 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376017786 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376017787 N-terminal plug; other site 762376017788 ligand-binding site [chemical binding]; other site 762376017789 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376017790 tricarballylate utilization protein B; Provisional; Region: PRK15033 762376017791 precorrin 3B synthase CobZ; Region: CobZ_N-term; TIGR02485 762376017792 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017794 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 762376017795 putative dimerization interface [polypeptide binding]; other site 762376017796 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762376017797 Cytochrome c; Region: Cytochrom_C; pfam00034 762376017798 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762376017799 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762376017800 Cytochrome c; Region: Cytochrom_C; pfam00034 762376017801 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376017802 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 762376017803 C-terminal domain interface [polypeptide binding]; other site 762376017804 GSH binding site (G-site) [chemical binding]; other site 762376017805 dimer interface [polypeptide binding]; other site 762376017806 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 762376017807 dimer interface [polypeptide binding]; other site 762376017808 N-terminal domain interface [polypeptide binding]; other site 762376017809 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 762376017810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 762376017811 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 762376017812 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 762376017813 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 762376017814 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 762376017815 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 762376017816 Clp amino terminal domain; Region: Clp_N; pfam02861 762376017817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376017818 Walker A motif; other site 762376017819 ATP binding site [chemical binding]; other site 762376017820 Walker B motif; other site 762376017821 arginine finger; other site 762376017822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376017823 Walker A motif; other site 762376017824 ATP binding site [chemical binding]; other site 762376017825 Walker B motif; other site 762376017826 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 762376017827 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 762376017828 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 762376017829 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 762376017830 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 762376017831 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 762376017832 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 762376017833 Protein of unknown function (DUF877); Region: DUF877; pfam05943 762376017834 Protein of unknown function (DUF770); Region: DUF770; pfam05591 762376017835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762376017836 TPR motif; other site 762376017837 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 762376017838 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 762376017839 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 762376017840 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 762376017841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 762376017842 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 762376017843 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 762376017844 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 762376017845 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 762376017846 putative metal dependent hydrolase; Provisional; Region: PRK11598 762376017847 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 762376017848 putative active site [active] 762376017849 catalytic site [active] 762376017850 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 762376017851 putative active site [active] 762376017852 catalytic site [active] 762376017853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 762376017854 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 762376017855 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 762376017856 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 762376017857 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 762376017858 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 762376017859 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 762376017860 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 762376017861 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 762376017862 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 762376017863 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 762376017864 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 762376017865 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376017866 ligand binding site [chemical binding]; other site 762376017867 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 762376017868 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 762376017869 PAAR motif; Region: PAAR_motif; pfam05488 762376017870 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 762376017871 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 762376017872 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 762376017873 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 762376017874 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376017875 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376017876 metal binding site [ion binding]; metal-binding site 762376017877 active site 762376017878 I-site; other site 762376017879 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 762376017880 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 762376017881 dimer interface [polypeptide binding]; other site 762376017882 PYR/PP interface [polypeptide binding]; other site 762376017883 TPP binding site [chemical binding]; other site 762376017884 substrate binding site [chemical binding]; other site 762376017885 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 762376017886 TPP-binding site; other site 762376017887 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 762376017888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017890 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 762376017891 putative substrate binding pocket [chemical binding]; other site 762376017892 dimerization interface [polypeptide binding]; other site 762376017893 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017894 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017895 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 762376017896 putative dimerization interface [polypeptide binding]; other site 762376017897 Amino acid synthesis; Region: AA_synth; pfam06684 762376017898 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 762376017899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376017900 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 762376017901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376017902 Walker A motif; other site 762376017903 ATP binding site [chemical binding]; other site 762376017904 Walker B motif; other site 762376017905 arginine finger; other site 762376017906 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762376017907 SnoaL-like domain; Region: SnoaL_2; pfam12680 762376017908 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 762376017909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 762376017910 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376017911 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376017912 DNA-binding site [nucleotide binding]; DNA binding site 762376017913 FCD domain; Region: FCD; pfam07729 762376017914 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 762376017915 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 762376017916 substrate binding site [chemical binding]; other site 762376017917 ligand binding site [chemical binding]; other site 762376017918 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 762376017919 substrate binding site [chemical binding]; other site 762376017920 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 762376017921 Peptidase family M48; Region: Peptidase_M48; cl12018 762376017922 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 762376017923 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 762376017924 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 762376017925 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 762376017926 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017928 LysR substrate binding domain; Region: LysR_substrate; pfam03466 762376017929 dimerization interface [polypeptide binding]; other site 762376017930 cytosine deaminase; Provisional; Region: PRK05985 762376017931 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 762376017932 active site 762376017933 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 762376017934 Na binding site [ion binding]; other site 762376017935 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376017936 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376017937 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 762376017938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376017939 active site 762376017940 phosphorylation site [posttranslational modification] 762376017941 intermolecular recognition site; other site 762376017942 dimerization interface [polypeptide binding]; other site 762376017943 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376017944 DNA binding site [nucleotide binding] 762376017945 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 762376017946 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376017947 dimerization interface [polypeptide binding]; other site 762376017948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376017949 dimer interface [polypeptide binding]; other site 762376017950 phosphorylation site [posttranslational modification] 762376017951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376017952 ATP binding site [chemical binding]; other site 762376017953 Mg2+ binding site [ion binding]; other site 762376017954 G-X-G motif; other site 762376017955 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 762376017956 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 762376017957 Multicopper oxidase; Region: Cu-oxidase; pfam00394 762376017958 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 762376017959 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 762376017960 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762376017961 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376017962 metal-binding site [ion binding] 762376017963 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762376017964 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376017965 metal-binding site [ion binding] 762376017966 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376017967 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 762376017968 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 762376017969 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 762376017970 active sites [active] 762376017971 tetramer interface [polypeptide binding]; other site 762376017972 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 762376017973 Prostaglandin dehydrogenases; Region: PGDH; cd05288 762376017974 NAD(P) binding site [chemical binding]; other site 762376017975 substrate binding site [chemical binding]; other site 762376017976 dimer interface [polypeptide binding]; other site 762376017977 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 762376017978 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762376017979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017981 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376017982 dimerization interface [polypeptide binding]; other site 762376017983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376017984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376017985 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376017986 dimerization interface [polypeptide binding]; other site 762376017987 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 762376017988 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 762376017989 acyl-activating enzyme (AAE) consensus motif; other site 762376017990 putative AMP binding site [chemical binding]; other site 762376017991 putative active site [active] 762376017992 putative CoA binding site [chemical binding]; other site 762376017993 aldolase II superfamily protein; Provisional; Region: PRK07044 762376017994 active site 762376017995 intersubunit interface [polypeptide binding]; other site 762376017996 Zn2+ binding site [ion binding]; other site 762376017997 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 762376017998 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 762376017999 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 762376018000 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 762376018001 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018002 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 762376018003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 762376018004 Patatin-like phospholipase; Region: Patatin; pfam01734 762376018005 benzoate transporter; Region: benE; TIGR00843 762376018006 Benzoate membrane transport protein; Region: BenE; pfam03594 762376018007 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 762376018008 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 762376018009 dimer interface [polypeptide binding]; other site 762376018010 active site 762376018011 glycine-pyridoxal phosphate binding site [chemical binding]; other site 762376018012 folate binding site [chemical binding]; other site 762376018013 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376018014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376018015 DNA-binding site [nucleotide binding]; DNA binding site 762376018016 Protein of unknown function (DUF3984); Region: DUF3984; pfam13136 762376018017 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376018018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376018019 homodimer interface [polypeptide binding]; other site 762376018020 catalytic residue [active] 762376018021 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 762376018022 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376018023 catalytic residue [active] 762376018024 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 762376018025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018026 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376018027 dimerization interface [polypeptide binding]; other site 762376018028 substrate binding pocket [chemical binding]; other site 762376018029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376018030 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376018031 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 762376018032 inhibitor site; inhibition site 762376018033 active site 762376018034 dimer interface [polypeptide binding]; other site 762376018035 catalytic residue [active] 762376018036 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 762376018037 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018038 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376018039 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376018040 DNA-binding site [nucleotide binding]; DNA binding site 762376018041 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376018042 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 762376018043 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 762376018044 catalytic triad [active] 762376018045 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 762376018046 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376018047 catalytic residue [active] 762376018048 Cupin; Region: Cupin_6; pfam12852 762376018049 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376018050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376018051 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 762376018052 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 762376018053 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376018054 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 762376018055 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 762376018056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376018057 DNA-binding site [nucleotide binding]; DNA binding site 762376018058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376018059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376018060 homodimer interface [polypeptide binding]; other site 762376018061 catalytic residue [active] 762376018062 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 762376018063 lysine decarboxylase LdcC; Provisional; Region: PRK15399 762376018064 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376018065 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376018066 catalytic residue [active] 762376018067 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 762376018068 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 762376018069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018070 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 762376018071 putative dimerization interface [polypeptide binding]; other site 762376018072 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762376018073 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762376018074 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 762376018075 active site 762376018076 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376018077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376018078 dimer interface [polypeptide binding]; other site 762376018079 conserved gate region; other site 762376018080 ABC-ATPase subunit interface; other site 762376018081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 762376018082 NMT1/THI5 like; Region: NMT1; pfam09084 762376018083 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376018084 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762376018085 Walker A/P-loop; other site 762376018086 ATP binding site [chemical binding]; other site 762376018087 Q-loop/lid; other site 762376018088 ABC transporter signature motif; other site 762376018089 Walker B; other site 762376018090 D-loop; other site 762376018091 H-loop/switch region; other site 762376018092 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762376018093 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376018094 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 762376018095 AsnC family; Region: AsnC_trans_reg; pfam01037 762376018096 Histidine kinase; Region: His_kinase; pfam06580 762376018097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 762376018098 ATP binding site [chemical binding]; other site 762376018099 Mg2+ binding site [ion binding]; other site 762376018100 G-X-G motif; other site 762376018101 Response regulator receiver domain; Region: Response_reg; pfam00072 762376018102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376018103 active site 762376018104 phosphorylation site [posttranslational modification] 762376018105 intermolecular recognition site; other site 762376018106 dimerization interface [polypeptide binding]; other site 762376018107 LytTr DNA-binding domain; Region: LytTR; smart00850 762376018108 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 762376018109 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 762376018110 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018111 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376018112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018114 dimerization interface [polypeptide binding]; other site 762376018115 Cache domain; Region: Cache_1; pfam02743 762376018116 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376018117 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376018118 metal binding site [ion binding]; metal-binding site 762376018119 active site 762376018120 I-site; other site 762376018121 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018122 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376018123 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376018124 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 762376018125 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376018126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376018127 homodimer interface [polypeptide binding]; other site 762376018128 catalytic residue [active] 762376018129 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762376018130 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376018131 metal binding site [ion binding]; metal-binding site 762376018132 enoyl-CoA hydratase; Provisional; Region: PRK09245 762376018133 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376018134 substrate binding site [chemical binding]; other site 762376018135 oxyanion hole (OAH) forming residues; other site 762376018136 trimer interface [polypeptide binding]; other site 762376018137 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376018138 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376018139 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376018140 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376018141 active site 762376018142 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376018143 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376018144 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018145 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018146 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762376018147 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 762376018148 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376018149 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762376018150 conserved cys residue [active] 762376018151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376018152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376018153 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762376018154 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 762376018155 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 762376018156 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 762376018157 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 762376018158 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 762376018159 molybdopterin cofactor binding site [chemical binding]; other site 762376018160 substrate binding site [chemical binding]; other site 762376018161 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 762376018162 molybdopterin cofactor binding site; other site 762376018163 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018164 short chain dehydrogenase; Provisional; Region: PRK06125 762376018165 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 762376018166 putative NAD(P) binding site [chemical binding]; other site 762376018167 putative active site [active] 762376018168 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762376018169 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762376018170 dimer interface [polypeptide binding]; other site 762376018171 active site 762376018172 catalytic residue [active] 762376018173 cystathionine beta-lyase; Provisional; Region: PRK09028 762376018174 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762376018175 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762376018176 catalytic residue [active] 762376018177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018178 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 762376018179 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376018180 dimerization interface [polypeptide binding]; other site 762376018181 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376018182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376018183 dimerization interface [polypeptide binding]; other site 762376018184 putative DNA binding site [nucleotide binding]; other site 762376018185 putative Zn2+ binding site [ion binding]; other site 762376018186 AsnC family; Region: AsnC_trans_reg; pfam01037 762376018187 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 762376018188 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 762376018189 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 762376018190 thiS-thiF/thiG interaction site; other site 762376018191 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 762376018192 BON domain; Region: BON; pfam04972 762376018193 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762376018194 signal recognition particle protein; Provisional; Region: PRK10867 762376018195 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 762376018196 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 762376018197 GTP binding site [chemical binding]; other site 762376018198 Signal peptide binding domain; Region: SRP_SPB; pfam02978 762376018199 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 762376018200 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 762376018201 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 762376018202 amidase catalytic site [active] 762376018203 Zn binding residues [ion binding]; other site 762376018204 substrate binding site [chemical binding]; other site 762376018205 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376018206 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 762376018207 putative C-terminal domain interface [polypeptide binding]; other site 762376018208 putative GSH binding site (G-site) [chemical binding]; other site 762376018209 putative dimer interface [polypeptide binding]; other site 762376018210 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 762376018211 putative N-terminal domain interface [polypeptide binding]; other site 762376018212 putative dimer interface [polypeptide binding]; other site 762376018213 putative substrate binding pocket (H-site) [chemical binding]; other site 762376018214 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376018215 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376018216 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376018217 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 762376018218 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 762376018219 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 762376018220 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 762376018221 active site 762376018222 intersubunit interface [polypeptide binding]; other site 762376018223 catalytic residue [active] 762376018224 galactonate dehydratase; Provisional; Region: PRK14017 762376018225 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 762376018226 putative active site pocket [active] 762376018227 putative metal binding site [ion binding]; other site 762376018228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376018229 D-galactonate transporter; Region: 2A0114; TIGR00893 762376018230 putative substrate translocation pore; other site 762376018231 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376018232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376018233 putative substrate translocation pore; other site 762376018234 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376018235 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376018236 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376018237 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376018238 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 762376018239 non-specific DNA interactions [nucleotide binding]; other site 762376018240 DNA binding site [nucleotide binding] 762376018241 sequence specific DNA binding site [nucleotide binding]; other site 762376018242 putative cAMP binding site [chemical binding]; other site 762376018243 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376018244 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376018245 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376018246 active site 762376018247 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018248 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018249 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376018250 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376018251 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376018252 active site 762376018253 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 762376018254 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 762376018255 NADP binding site [chemical binding]; other site 762376018256 dimer interface [polypeptide binding]; other site 762376018257 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376018258 CoA binding domain; Region: CoA_binding_2; pfam13380 762376018259 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762376018260 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762376018261 HipA N-terminal domain; Region: Couple_hipA; pfam13657 762376018262 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 762376018263 HipA-like N-terminal domain; Region: HipA_N; pfam07805 762376018264 HipA-like C-terminal domain; Region: HipA_C; pfam07804 762376018265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376018266 non-specific DNA binding site [nucleotide binding]; other site 762376018267 salt bridge; other site 762376018268 sequence-specific DNA binding site [nucleotide binding]; other site 762376018269 heat shock protein 90; Provisional; Region: PRK05218 762376018270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376018271 ATP binding site [chemical binding]; other site 762376018272 Mg2+ binding site [ion binding]; other site 762376018273 G-X-G motif; other site 762376018274 DKNYY family; Region: DKNYY; pfam13644 762376018275 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 762376018276 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 762376018277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376018278 motif II; other site 762376018279 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018280 glutathionine S-transferase; Provisional; Region: PRK10542 762376018281 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 762376018282 C-terminal domain interface [polypeptide binding]; other site 762376018283 GSH binding site (G-site) [chemical binding]; other site 762376018284 dimer interface [polypeptide binding]; other site 762376018285 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 762376018286 dimer interface [polypeptide binding]; other site 762376018287 N-terminal domain interface [polypeptide binding]; other site 762376018288 substrate binding pocket (H-site) [chemical binding]; other site 762376018289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376018290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018291 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376018292 dimerization interface [polypeptide binding]; other site 762376018293 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 762376018294 multidrug resistance protein MdtN; Provisional; Region: PRK10476 762376018295 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376018296 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376018297 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 762376018298 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 762376018299 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 762376018300 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 762376018301 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376018302 substrate binding pocket [chemical binding]; other site 762376018303 membrane-bound complex binding site; other site 762376018304 hinge residues; other site 762376018305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376018306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018308 dimerization interface [polypeptide binding]; other site 762376018309 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018310 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376018311 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376018312 MlrC C-terminus; Region: MlrC_C; pfam07171 762376018313 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 762376018314 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376018315 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 762376018316 Walker A/P-loop; other site 762376018317 ATP binding site [chemical binding]; other site 762376018318 Q-loop/lid; other site 762376018319 ABC transporter signature motif; other site 762376018320 Walker B; other site 762376018321 D-loop; other site 762376018322 H-loop/switch region; other site 762376018323 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 762376018324 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376018325 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 762376018326 TM-ABC transporter signature motif; other site 762376018327 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 762376018328 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 762376018329 nucleotide binding site [chemical binding]; other site 762376018330 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 762376018331 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376018332 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376018333 putative ligand binding site [chemical binding]; other site 762376018334 short chain dehydrogenase; Provisional; Region: PRK12829 762376018335 classical (c) SDRs; Region: SDR_c; cd05233 762376018336 NAD(P) binding site [chemical binding]; other site 762376018337 active site 762376018338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376018339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018341 dimerization interface [polypeptide binding]; other site 762376018342 Uncharacterized conserved protein [Function unknown]; Region: COG5361 762376018343 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 762376018344 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 762376018345 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 762376018346 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 762376018347 Cupin domain; Region: Cupin_2; cl17218 762376018348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376018349 putative substrate translocation pore; other site 762376018350 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376018351 KWG Leptospira; Region: KWG; pfam07656 762376018352 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762376018353 tetramer interface [polypeptide binding]; other site 762376018354 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 762376018355 active site 762376018356 Mg2+/Mn2+ binding site [ion binding]; other site 762376018357 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 762376018358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018359 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 762376018360 putative dimerization interface [polypeptide binding]; other site 762376018361 putative substrate binding pocket [chemical binding]; other site 762376018362 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 762376018363 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 762376018364 FAD binding pocket [chemical binding]; other site 762376018365 FAD binding motif [chemical binding]; other site 762376018366 phosphate binding motif [ion binding]; other site 762376018367 NAD binding pocket [chemical binding]; other site 762376018368 Predicted transcriptional regulators [Transcription]; Region: COG1695 762376018369 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 762376018370 EamA-like transporter family; Region: EamA; pfam00892 762376018371 EamA-like transporter family; Region: EamA; pfam00892 762376018372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376018373 salt bridge; other site 762376018374 non-specific DNA binding site [nucleotide binding]; other site 762376018375 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376018376 sequence-specific DNA binding site [nucleotide binding]; other site 762376018377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376018378 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762376018379 putative substrate translocation pore; other site 762376018380 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 762376018381 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762376018382 Domain of unknown function DUF20; Region: UPF0118; pfam01594 762376018383 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376018384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018385 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 762376018386 putative effector binding pocket; other site 762376018387 putative dimerization interface [polypeptide binding]; other site 762376018388 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762376018389 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762376018390 HlyD family secretion protein; Region: HlyD_3; pfam13437 762376018391 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 762376018392 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 762376018393 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 762376018394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018396 dimerization interface [polypeptide binding]; other site 762376018397 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 762376018398 Cupin domain; Region: Cupin_2; pfam07883 762376018399 Cupin domain; Region: Cupin_2; cl17218 762376018400 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376018401 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376018402 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 762376018403 maleylacetoacetate isomerase; Region: maiA; TIGR01262 762376018404 C-terminal domain interface [polypeptide binding]; other site 762376018405 GSH binding site (G-site) [chemical binding]; other site 762376018406 putative dimer interface [polypeptide binding]; other site 762376018407 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 762376018408 dimer interface [polypeptide binding]; other site 762376018409 N-terminal domain interface [polypeptide binding]; other site 762376018410 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 762376018411 Chorismate mutase type II; Region: CM_2; pfam01817 762376018412 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018413 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 762376018414 salicylate hydroxylase; Provisional; Region: PRK08163 762376018415 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 762376018416 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376018417 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 762376018418 putative ligand binding site [chemical binding]; other site 762376018419 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376018420 TM-ABC transporter signature motif; other site 762376018421 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376018422 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376018423 TM-ABC transporter signature motif; other site 762376018424 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376018425 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376018426 Walker A/P-loop; other site 762376018427 ATP binding site [chemical binding]; other site 762376018428 Q-loop/lid; other site 762376018429 ABC transporter signature motif; other site 762376018430 Walker B; other site 762376018431 D-loop; other site 762376018432 H-loop/switch region; other site 762376018433 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376018434 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376018435 Walker A/P-loop; other site 762376018436 ATP binding site [chemical binding]; other site 762376018437 Q-loop/lid; other site 762376018438 ABC transporter signature motif; other site 762376018439 Walker B; other site 762376018440 D-loop; other site 762376018441 H-loop/switch region; other site 762376018442 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 762376018443 dimer interface [polypeptide binding]; other site 762376018444 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376018445 ligand binding site [chemical binding]; other site 762376018446 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018447 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376018448 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376018449 substrate binding site [chemical binding]; other site 762376018450 oxyanion hole (OAH) forming residues; other site 762376018451 trimer interface [polypeptide binding]; other site 762376018452 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376018453 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376018454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376018455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018456 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018457 dimerization interface [polypeptide binding]; other site 762376018458 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018459 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 762376018460 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 762376018461 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376018462 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762376018463 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 762376018464 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762376018465 carboxyltransferase (CT) interaction site; other site 762376018466 biotinylation site [posttranslational modification]; other site 762376018467 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376018468 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376018469 active site 762376018470 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 762376018471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 762376018472 substrate binding site [chemical binding]; other site 762376018473 oxyanion hole (OAH) forming residues; other site 762376018474 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762376018475 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762376018476 Walker A/P-loop; other site 762376018477 ATP binding site [chemical binding]; other site 762376018478 Q-loop/lid; other site 762376018479 ABC transporter signature motif; other site 762376018480 Walker B; other site 762376018481 D-loop; other site 762376018482 H-loop/switch region; other site 762376018483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376018484 dimer interface [polypeptide binding]; other site 762376018485 conserved gate region; other site 762376018486 putative PBP binding loops; other site 762376018487 ABC-ATPase subunit interface; other site 762376018488 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 762376018489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376018490 conserved gate region; other site 762376018491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376018492 dimer interface [polypeptide binding]; other site 762376018493 conserved gate region; other site 762376018494 putative PBP binding loops; other site 762376018495 ABC-ATPase subunit interface; other site 762376018496 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 762376018497 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376018498 substrate binding pocket [chemical binding]; other site 762376018499 membrane-bound complex binding site; other site 762376018500 hinge residues; other site 762376018501 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 762376018502 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762376018503 Walker A/P-loop; other site 762376018504 ATP binding site [chemical binding]; other site 762376018505 Q-loop/lid; other site 762376018506 ABC transporter signature motif; other site 762376018507 Walker B; other site 762376018508 D-loop; other site 762376018509 H-loop/switch region; other site 762376018510 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 762376018511 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 762376018512 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 762376018513 2'-5' RNA ligase; Provisional; Region: PRK15124 762376018514 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 762376018515 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 762376018516 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 762376018517 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 762376018518 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 762376018519 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376018520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376018521 DNA-binding site [nucleotide binding]; DNA binding site 762376018522 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376018523 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376018524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376018525 NAD(P) binding site [chemical binding]; other site 762376018526 active site 762376018527 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 762376018528 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 762376018529 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 762376018530 shikimate binding site; other site 762376018531 NAD(P) binding site [chemical binding]; other site 762376018532 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376018533 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 762376018534 putative ligand binding site [chemical binding]; other site 762376018535 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376018536 TM-ABC transporter signature motif; other site 762376018537 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376018538 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376018539 TM-ABC transporter signature motif; other site 762376018540 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376018541 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376018542 Walker A/P-loop; other site 762376018543 ATP binding site [chemical binding]; other site 762376018544 Q-loop/lid; other site 762376018545 ABC transporter signature motif; other site 762376018546 Walker B; other site 762376018547 D-loop; other site 762376018548 H-loop/switch region; other site 762376018549 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376018550 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376018551 Walker A/P-loop; other site 762376018552 ATP binding site [chemical binding]; other site 762376018553 Q-loop/lid; other site 762376018554 ABC transporter signature motif; other site 762376018555 Walker B; other site 762376018556 D-loop; other site 762376018557 H-loop/switch region; other site 762376018558 short chain dehydrogenase; Provisional; Region: PRK06841 762376018559 classical (c) SDRs; Region: SDR_c; cd05233 762376018560 NAD(P) binding site [chemical binding]; other site 762376018561 active site 762376018562 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 762376018563 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762376018564 tetramer interface [polypeptide binding]; other site 762376018565 TPP-binding site [chemical binding]; other site 762376018566 heterodimer interface [polypeptide binding]; other site 762376018567 phosphorylation loop region [posttranslational modification] 762376018568 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762376018569 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762376018570 alpha subunit interface [polypeptide binding]; other site 762376018571 TPP binding site [chemical binding]; other site 762376018572 heterodimer interface [polypeptide binding]; other site 762376018573 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762376018574 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 762376018575 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376018576 active site 762376018577 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762376018578 E3 interaction surface; other site 762376018579 lipoyl attachment site [posttranslational modification]; other site 762376018580 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 762376018581 e3 binding domain; Region: E3_binding; pfam02817 762376018582 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762376018583 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 762376018584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762376018585 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762376018586 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376018587 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018588 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018589 dimerization interface [polypeptide binding]; other site 762376018590 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 762376018591 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762376018592 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376018593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018594 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018595 dimerization interface [polypeptide binding]; other site 762376018596 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 762376018597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376018598 Coenzyme A binding pocket [chemical binding]; other site 762376018599 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376018600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 762376018601 putative substrate translocation pore; other site 762376018602 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 762376018603 Ligand Binding Site [chemical binding]; other site 762376018604 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 762376018605 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 762376018606 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 762376018607 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376018608 DNA binding residues [nucleotide binding] 762376018609 fec operon regulator FecR; Reviewed; Region: PRK09774 762376018610 FecR protein; Region: FecR; pfam04773 762376018611 Secretin and TonB N terminus short domain; Region: STN; smart00965 762376018612 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 762376018613 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376018614 N-terminal plug; other site 762376018615 ligand-binding site [chemical binding]; other site 762376018616 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 762376018617 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376018618 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376018619 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 762376018620 short chain dehydrogenase; Provisional; Region: PRK07577 762376018621 classical (c) SDRs; Region: SDR_c; cd05233 762376018622 NAD(P) binding site [chemical binding]; other site 762376018623 active site 762376018624 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 762376018625 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376018626 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376018627 Coenzyme A transferase; Region: CoA_trans; cl17247 762376018628 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 762376018629 Muconolactone delta-isomerase; Region: MIase; cl01992 762376018630 YciI-like protein; Reviewed; Region: PRK12863 762376018631 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 762376018632 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762376018633 Putative cyclase; Region: Cyclase; pfam04199 762376018634 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 762376018635 Flavoprotein; Region: Flavoprotein; pfam02441 762376018636 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 762376018637 putative GSH binding site [chemical binding]; other site 762376018638 catalytic residues [active] 762376018639 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 762376018640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762376018641 S-adenosylmethionine binding site [chemical binding]; other site 762376018642 peptide chain release factor 1; Validated; Region: prfA; PRK00591 762376018643 This domain is found in peptide chain release factors; Region: PCRF; smart00937 762376018644 RF-1 domain; Region: RF-1; pfam00472 762376018645 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 762376018646 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 762376018647 tRNA; other site 762376018648 putative tRNA binding site [nucleotide binding]; other site 762376018649 putative NADP binding site [chemical binding]; other site 762376018650 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 762376018651 Isochorismatase family; Region: Isochorismatase; pfam00857 762376018652 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 762376018653 catalytic triad [active] 762376018654 conserved cis-peptide bond; other site 762376018655 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018656 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376018657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018658 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 762376018659 dimerization interface [polypeptide binding]; other site 762376018660 substrate binding pocket [chemical binding]; other site 762376018661 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 762376018662 Mechanosensitive ion channel; Region: MS_channel; pfam00924 762376018663 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762376018664 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762376018665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376018666 Walker A/P-loop; other site 762376018667 ATP binding site [chemical binding]; other site 762376018668 Q-loop/lid; other site 762376018669 ABC transporter signature motif; other site 762376018670 Walker B; other site 762376018671 D-loop; other site 762376018672 H-loop/switch region; other site 762376018673 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 762376018674 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376018675 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376018676 motif II; other site 762376018677 Abi-like protein; Region: Abi_2; pfam07751 762376018678 RNA polymerase sigma factor; Provisional; Region: PRK11922 762376018679 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376018680 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 762376018681 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 762376018682 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376018683 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 762376018684 putative DNA binding site [nucleotide binding]; other site 762376018685 putative Zn2+ binding site [ion binding]; other site 762376018686 AsnC family; Region: AsnC_trans_reg; pfam01037 762376018687 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376018688 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 762376018689 EamA-like transporter family; Region: EamA; pfam00892 762376018690 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018691 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 762376018692 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 762376018693 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 762376018694 active site 762376018695 catalytic residues [active] 762376018696 metal binding site [ion binding]; metal-binding site 762376018697 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376018698 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376018699 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376018700 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376018701 Walker A/P-loop; other site 762376018702 ATP binding site [chemical binding]; other site 762376018703 Q-loop/lid; other site 762376018704 ABC transporter signature motif; other site 762376018705 Walker B; other site 762376018706 D-loop; other site 762376018707 H-loop/switch region; other site 762376018708 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376018709 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376018710 TM-ABC transporter signature motif; other site 762376018711 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376018712 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376018713 Walker A/P-loop; other site 762376018714 ATP binding site [chemical binding]; other site 762376018715 Q-loop/lid; other site 762376018716 ABC transporter signature motif; other site 762376018717 Walker B; other site 762376018718 D-loop; other site 762376018719 H-loop/switch region; other site 762376018720 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376018721 TM-ABC transporter signature motif; other site 762376018722 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376018723 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376018724 choline dehydrogenase; Validated; Region: PRK02106 762376018725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376018726 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 762376018727 succinic semialdehyde dehydrogenase; Region: PLN02278 762376018728 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762376018729 tetramerization interface [polypeptide binding]; other site 762376018730 NAD(P) binding site [chemical binding]; other site 762376018731 catalytic residues [active] 762376018732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376018733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018734 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 762376018735 putative dimerization interface [polypeptide binding]; other site 762376018736 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 762376018737 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 762376018738 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 762376018739 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376018740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376018741 DNA-binding site [nucleotide binding]; DNA binding site 762376018742 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376018743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 762376018744 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376018745 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762376018746 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 762376018747 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 762376018748 putative NAD(P) binding site [chemical binding]; other site 762376018749 active site 762376018750 putative substrate binding site [chemical binding]; other site 762376018751 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 762376018752 putative aldolase; Validated; Region: PRK08130 762376018753 intersubunit interface [polypeptide binding]; other site 762376018754 active site 762376018755 Zn2+ binding site [ion binding]; other site 762376018756 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376018757 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762376018758 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 762376018759 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 762376018760 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376018761 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376018762 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376018763 TM-ABC transporter signature motif; other site 762376018764 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376018765 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376018766 TM-ABC transporter signature motif; other site 762376018767 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376018768 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376018769 Walker A/P-loop; other site 762376018770 ATP binding site [chemical binding]; other site 762376018771 Q-loop/lid; other site 762376018772 ABC transporter signature motif; other site 762376018773 Walker B; other site 762376018774 D-loop; other site 762376018775 H-loop/switch region; other site 762376018776 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376018777 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376018778 Walker A/P-loop; other site 762376018779 ATP binding site [chemical binding]; other site 762376018780 Q-loop/lid; other site 762376018781 ABC transporter signature motif; other site 762376018782 Walker B; other site 762376018783 D-loop; other site 762376018784 H-loop/switch region; other site 762376018785 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376018786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376018787 DNA-binding site [nucleotide binding]; DNA binding site 762376018788 FCD domain; Region: FCD; pfam07729 762376018789 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376018790 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762376018791 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 762376018792 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762376018793 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 762376018794 Isochorismatase family; Region: Isochorismatase; pfam00857 762376018795 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 762376018796 catalytic triad [active] 762376018797 conserved cis-peptide bond; other site 762376018798 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 762376018799 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762376018800 Cyclic amidohydrolases, including hydantoinase, dihydropyrimidinase, allantoinase, and dihydroorotase, are involved in the metabolism of pyrimidines and purines, sharing the property of hydrolyzing the cyclic amide bond of each substrate to the...; Region: Cyclic_amidohydrolases; cd01302 762376018801 active site 762376018802 tetramer interface [polypeptide binding]; other site 762376018803 aconitate hydratase; Validated; Region: PRK09277 762376018804 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 762376018805 substrate binding site [chemical binding]; other site 762376018806 ligand binding site [chemical binding]; other site 762376018807 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 762376018808 substrate binding site [chemical binding]; other site 762376018809 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376018810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376018811 DNA-binding site [nucleotide binding]; DNA binding site 762376018812 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376018813 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762376018814 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 762376018815 tetramer interface [polypeptide binding]; other site 762376018816 active site 762376018817 Mg2+/Mn2+ binding site [ion binding]; other site 762376018818 classical (c) SDRs; Region: SDR_c; cd05233 762376018819 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 762376018820 NAD(P) binding site [chemical binding]; other site 762376018821 active site 762376018822 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 762376018823 classical (c) SDRs; Region: SDR_c; cd05233 762376018824 NAD(P) binding site [chemical binding]; other site 762376018825 active site 762376018826 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018827 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 762376018828 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376018829 N-terminal plug; other site 762376018830 ligand-binding site [chemical binding]; other site 762376018831 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 762376018832 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 762376018833 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 762376018834 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 762376018835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376018836 ATP binding site [chemical binding]; other site 762376018837 Mg2+ binding site [ion binding]; other site 762376018838 G-X-G motif; other site 762376018839 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376018840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376018841 active site 762376018842 phosphorylation site [posttranslational modification] 762376018843 intermolecular recognition site; other site 762376018844 dimerization interface [polypeptide binding]; other site 762376018845 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376018846 DNA binding residues [nucleotide binding] 762376018847 dimerization interface [polypeptide binding]; other site 762376018848 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 762376018849 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 762376018850 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376018851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376018852 active site 762376018853 phosphorylation site [posttranslational modification] 762376018854 intermolecular recognition site; other site 762376018855 dimerization interface [polypeptide binding]; other site 762376018856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376018857 DNA binding residues [nucleotide binding] 762376018858 dimerization interface [polypeptide binding]; other site 762376018859 PAS fold; Region: PAS_4; pfam08448 762376018860 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 762376018861 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376018862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376018863 dimer interface [polypeptide binding]; other site 762376018864 phosphorylation site [posttranslational modification] 762376018865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376018866 ATP binding site [chemical binding]; other site 762376018867 Mg2+ binding site [ion binding]; other site 762376018868 G-X-G motif; other site 762376018869 Response regulator receiver domain; Region: Response_reg; pfam00072 762376018870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376018871 active site 762376018872 phosphorylation site [posttranslational modification] 762376018873 intermolecular recognition site; other site 762376018874 dimerization interface [polypeptide binding]; other site 762376018875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762376018876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376018877 dimer interface [polypeptide binding]; other site 762376018878 phosphorylation site [posttranslational modification] 762376018879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376018880 ATP binding site [chemical binding]; other site 762376018881 Mg2+ binding site [ion binding]; other site 762376018882 G-X-G motif; other site 762376018883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376018884 Response regulator receiver domain; Region: Response_reg; pfam00072 762376018885 active site 762376018886 phosphorylation site [posttranslational modification] 762376018887 intermolecular recognition site; other site 762376018888 dimerization interface [polypeptide binding]; other site 762376018889 Fimbrial protein; Region: Fimbrial; cl01416 762376018890 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 762376018891 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 762376018892 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 762376018893 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 762376018894 PapC N-terminal domain; Region: PapC_N; pfam13954 762376018895 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 762376018896 PapC C-terminal domain; Region: PapC_C; pfam13953 762376018897 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 762376018898 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 762376018899 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 762376018900 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 762376018901 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 762376018902 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 762376018903 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 762376018904 PapC N-terminal domain; Region: PapC_N; pfam13954 762376018905 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 762376018906 PapC C-terminal domain; Region: PapC_C; pfam13953 762376018907 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 762376018908 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 762376018909 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 762376018910 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 762376018911 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 762376018912 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 762376018913 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 762376018914 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 762376018915 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 762376018916 Surface antigen; Region: Bac_surface_Ag; pfam01103 762376018917 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 762376018918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376018919 active site 762376018920 phosphorylation site [posttranslational modification] 762376018921 intermolecular recognition site; other site 762376018922 dimerization interface [polypeptide binding]; other site 762376018923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 762376018924 DNA binding residues [nucleotide binding] 762376018925 dimerization interface [polypeptide binding]; other site 762376018926 PAS domain S-box; Region: sensory_box; TIGR00229 762376018927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376018928 dimer interface [polypeptide binding]; other site 762376018929 phosphorylation site [posttranslational modification] 762376018930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376018931 ATP binding site [chemical binding]; other site 762376018932 Mg2+ binding site [ion binding]; other site 762376018933 G-X-G motif; other site 762376018934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376018935 active site 762376018936 phosphorylation site [posttranslational modification] 762376018937 intermolecular recognition site; other site 762376018938 Hpt domain; Region: Hpt; pfam01627 762376018939 Sulfatase; Region: Sulfatase; cl17466 762376018940 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376018941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376018942 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376018943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376018944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376018945 dimerization interface [polypeptide binding]; other site 762376018946 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376018947 MarR family; Region: MarR_2; cl17246 762376018948 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376018949 Sulfatase; Region: Sulfatase; cl17466 762376018950 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 762376018951 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 762376018952 putative active site [active] 762376018953 putative metal binding site [ion binding]; other site 762376018954 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 762376018955 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 762376018956 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762376018957 substrate binding pocket [chemical binding]; other site 762376018958 chain length determination region; other site 762376018959 substrate-Mg2+ binding site; other site 762376018960 catalytic residues [active] 762376018961 aspartate-rich region 1; other site 762376018962 active site lid residues [active] 762376018963 aspartate-rich region 2; other site 762376018964 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 762376018965 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376018966 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376018967 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376018968 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376018969 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 762376018970 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 762376018971 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 762376018972 GTPase CgtA; Reviewed; Region: obgE; PRK12299 762376018973 GTP1/OBG; Region: GTP1_OBG; pfam01018 762376018974 Obg GTPase; Region: Obg; cd01898 762376018975 G1 box; other site 762376018976 GTP/Mg2+ binding site [chemical binding]; other site 762376018977 Switch I region; other site 762376018978 G2 box; other site 762376018979 G3 box; other site 762376018980 Switch II region; other site 762376018981 G4 box; other site 762376018982 G5 box; other site 762376018983 gamma-glutamyl kinase; Provisional; Region: PRK05429 762376018984 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 762376018985 nucleotide binding site [chemical binding]; other site 762376018986 homotetrameric interface [polypeptide binding]; other site 762376018987 putative phosphate binding site [ion binding]; other site 762376018988 putative allosteric binding site; other site 762376018989 PUA domain; Region: PUA; pfam01472 762376018990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376018991 non-specific DNA binding site [nucleotide binding]; other site 762376018992 salt bridge; other site 762376018993 sequence-specific DNA binding site [nucleotide binding]; other site 762376018994 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 762376018995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376018996 non-specific DNA binding site [nucleotide binding]; other site 762376018997 salt bridge; other site 762376018998 sequence-specific DNA binding site [nucleotide binding]; other site 762376018999 putative transposase OrfB; Reviewed; Region: PHA02517 762376019000 HTH-like domain; Region: HTH_21; pfam13276 762376019001 Integrase core domain; Region: rve; pfam00665 762376019002 Integrase core domain; Region: rve_2; pfam13333 762376019003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376019004 Helix-turn-helix domain; Region: HTH_28; pfam13518 762376019005 Helix-turn-helix domain; Region: HTH_28; pfam13518 762376019006 protein-export membrane protein SecD; Region: secD; TIGR01129 762376019007 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 762376019008 ThiC-associated domain; Region: ThiC-associated; pfam13667 762376019009 ThiC family; Region: ThiC; pfam01964 762376019010 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376019011 FAD binding domain; Region: FAD_binding_4; pfam01565 762376019012 Transcriptional regulators [Transcription]; Region: FadR; COG2186 762376019013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376019014 DNA-binding site [nucleotide binding]; DNA binding site 762376019015 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 762376019016 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 762376019017 metal binding site [ion binding]; metal-binding site 762376019018 active site 762376019019 I-site; other site 762376019020 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 762376019021 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 762376019022 ATP binding site [chemical binding]; other site 762376019023 substrate interface [chemical binding]; other site 762376019024 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 762376019025 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 762376019026 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 762376019027 protein binding site [polypeptide binding]; other site 762376019028 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 762376019029 Catalytic dyad [active] 762376019030 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 762376019031 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 762376019032 Peptidase family M23; Region: Peptidase_M23; pfam01551 762376019033 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762376019034 catalytic core [active] 762376019035 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762376019036 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762376019037 active site residue [active] 762376019038 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 762376019039 GSH binding site [chemical binding]; other site 762376019040 catalytic residues [active] 762376019041 preprotein translocase subunit SecB; Validated; Region: PRK05751 762376019042 SecA binding site; other site 762376019043 Preprotein binding site; other site 762376019044 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 762376019045 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 762376019046 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 762376019047 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376019048 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 762376019049 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 762376019050 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 762376019051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376019052 S-adenosylmethionine binding site [chemical binding]; other site 762376019053 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 762376019054 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 762376019055 Cation transport protein; Region: TrkH; cl17365 762376019056 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 762376019057 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 762376019058 TrkA-N domain; Region: TrkA_N; pfam02254 762376019059 TrkA-C domain; Region: TrkA_C; pfam02080 762376019060 TrkA-N domain; Region: TrkA_N; pfam02254 762376019061 TrkA-C domain; Region: TrkA_C; pfam02080 762376019062 Response regulator receiver domain; Region: Response_reg; pfam00072 762376019063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376019064 active site 762376019065 phosphorylation site [posttranslational modification] 762376019066 intermolecular recognition site; other site 762376019067 dimerization interface [polypeptide binding]; other site 762376019068 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 762376019069 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762376019070 dimerization interface [polypeptide binding]; other site 762376019071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376019072 dimer interface [polypeptide binding]; other site 762376019073 phosphorylation site [posttranslational modification] 762376019074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376019075 ATP binding site [chemical binding]; other site 762376019076 Mg2+ binding site [ion binding]; other site 762376019077 G-X-G motif; other site 762376019078 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 762376019079 16S rRNA methyltransferase B; Provisional; Region: PRK10901 762376019080 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 762376019081 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376019082 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376019083 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 762376019084 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376019085 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376019086 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376019087 substrate binding site [chemical binding]; other site 762376019088 oxyanion hole (OAH) forming residues; other site 762376019089 trimer interface [polypeptide binding]; other site 762376019090 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 762376019091 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 762376019092 B12 binding site [chemical binding]; other site 762376019093 cobalt ligand [ion binding]; other site 762376019094 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376019095 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376019096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376019097 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762376019098 Walker A/P-loop; other site 762376019099 ATP binding site [chemical binding]; other site 762376019100 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376019101 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376019102 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 762376019103 putative ligand binding site [chemical binding]; other site 762376019104 oxidase reductase; Provisional; Region: PTZ00273 762376019105 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 762376019106 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 762376019107 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376019108 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 762376019109 NAD(P) binding site [chemical binding]; other site 762376019110 catalytic residues [active] 762376019111 catalytic residues [active] 762376019112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019113 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 762376019114 NAD(P) binding site [chemical binding]; other site 762376019115 active site 762376019116 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 762376019117 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 762376019118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376019119 active site 762376019120 phosphorylation site [posttranslational modification] 762376019121 intermolecular recognition site; other site 762376019122 dimerization interface [polypeptide binding]; other site 762376019123 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376019124 DNA binding site [nucleotide binding] 762376019125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376019126 dimer interface [polypeptide binding]; other site 762376019127 phosphorylation site [posttranslational modification] 762376019128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376019129 ATP binding site [chemical binding]; other site 762376019130 Mg2+ binding site [ion binding]; other site 762376019131 G-X-G motif; other site 762376019132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376019133 non-specific DNA binding site [nucleotide binding]; other site 762376019134 salt bridge; other site 762376019135 sequence-specific DNA binding site [nucleotide binding]; other site 762376019136 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 762376019137 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 762376019138 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762376019139 FeS/SAM binding site; other site 762376019140 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 762376019141 Predicted transcriptional regulators [Transcription]; Region: COG1733 762376019142 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376019143 putative Zn2+ binding site [ion binding]; other site 762376019144 putative DNA binding site [nucleotide binding]; other site 762376019145 Ferritin-like domain; Region: Ferritin; pfam00210 762376019146 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 762376019147 dinuclear metal binding motif [ion binding]; other site 762376019148 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 762376019149 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 762376019150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 762376019151 motif II; other site 762376019152 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 762376019153 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 762376019154 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 762376019155 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 762376019156 putative active site [active] 762376019157 substrate binding site [chemical binding]; other site 762376019158 putative cosubstrate binding site; other site 762376019159 catalytic site [active] 762376019160 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 762376019161 substrate binding site [chemical binding]; other site 762376019162 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 762376019163 active site 762376019164 catalytic residues [active] 762376019165 metal binding site [ion binding]; metal-binding site 762376019166 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 762376019167 DNA protecting protein DprA; Region: dprA; TIGR00732 762376019168 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 762376019169 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 762376019170 active site 762376019171 catalytic residues [active] 762376019172 metal binding site [ion binding]; metal-binding site 762376019173 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762376019174 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 762376019175 substrate binding pocket [chemical binding]; other site 762376019176 membrane-bound complex binding site; other site 762376019177 hinge residues; other site 762376019178 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376019179 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 762376019180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376019181 homodimer interface [polypeptide binding]; other site 762376019182 catalytic residue [active] 762376019183 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 762376019184 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376019185 catalytic residue [active] 762376019186 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376019187 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 762376019188 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376019189 FAD binding domain; Region: FAD_binding_4; pfam01565 762376019190 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 762376019191 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 762376019192 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 762376019193 Cysteine-rich domain; Region: CCG; pfam02754 762376019194 Cysteine-rich domain; Region: CCG; pfam02754 762376019195 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 762376019196 Predicted membrane protein [Function unknown]; Region: COG1238 762376019197 threonine dehydratase; Reviewed; Region: PRK09224 762376019198 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 762376019199 tetramer interface [polypeptide binding]; other site 762376019200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376019201 catalytic residue [active] 762376019202 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 762376019203 putative Ile/Val binding site [chemical binding]; other site 762376019204 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 762376019205 putative Ile/Val binding site [chemical binding]; other site 762376019206 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 762376019207 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 762376019208 trimer interface [polypeptide binding]; other site 762376019209 eyelet of channel; other site 762376019210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762376019211 Helix-turn-helix domain; Region: HTH_28; pfam13518 762376019212 Helix-turn-helix domain; Region: HTH_28; pfam13518 762376019213 putative transposase OrfB; Reviewed; Region: PHA02517 762376019214 HTH-like domain; Region: HTH_21; pfam13276 762376019215 Integrase core domain; Region: rve; pfam00665 762376019216 Integrase core domain; Region: rve_2; pfam13333 762376019217 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 762376019218 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376019219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376019220 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 762376019221 putative effector binding pocket; other site 762376019222 dimerization interface [polypeptide binding]; other site 762376019223 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762376019224 active site 762376019225 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 762376019226 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762376019227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376019228 Walker A/P-loop; other site 762376019229 ATP binding site [chemical binding]; other site 762376019230 Q-loop/lid; other site 762376019231 ABC transporter signature motif; other site 762376019232 Walker B; other site 762376019233 D-loop; other site 762376019234 H-loop/switch region; other site 762376019235 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 762376019236 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762376019237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376019238 Walker A/P-loop; other site 762376019239 ATP binding site [chemical binding]; other site 762376019240 Q-loop/lid; other site 762376019241 ABC transporter signature motif; other site 762376019242 Walker B; other site 762376019243 D-loop; other site 762376019244 H-loop/switch region; other site 762376019245 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 762376019246 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 762376019247 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 762376019248 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 762376019249 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 762376019250 Predicted transcriptional regulators [Transcription]; Region: COG1510 762376019251 MarR family; Region: MarR_2; pfam12802 762376019252 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 762376019253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019254 ATP-grasp domain; Region: ATP-grasp; pfam02222 762376019255 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 762376019256 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 762376019257 putative active site [active] 762376019258 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 762376019259 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 762376019260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376019261 active site 762376019262 motif I; other site 762376019263 motif II; other site 762376019264 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 762376019265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 762376019266 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 762376019267 OstA-like protein; Region: OstA; pfam03968 762376019268 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 762376019269 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 762376019270 Walker A/P-loop; other site 762376019271 ATP binding site [chemical binding]; other site 762376019272 Q-loop/lid; other site 762376019273 ABC transporter signature motif; other site 762376019274 Walker B; other site 762376019275 D-loop; other site 762376019276 H-loop/switch region; other site 762376019277 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 762376019278 30S subunit binding site; other site 762376019279 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 762376019280 active site 762376019281 phosphorylation site [posttranslational modification] 762376019282 HPr kinase/phosphorylase; Provisional; Region: PRK05428 762376019283 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 762376019284 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 762376019285 Hpr binding site; other site 762376019286 active site 762376019287 homohexamer subunit interaction site [polypeptide binding]; other site 762376019288 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 762376019289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376019290 DNA-binding site [nucleotide binding]; DNA binding site 762376019291 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376019292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376019293 homodimer interface [polypeptide binding]; other site 762376019294 catalytic residue [active] 762376019295 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762376019296 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762376019297 Cytochrome c; Region: Cytochrom_C; pfam00034 762376019298 Cytochrome c; Region: Cytochrom_C; cl11414 762376019299 Cytochrome c; Region: Cytochrom_C; cl11414 762376019300 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 762376019301 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 762376019302 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 762376019303 Sporulation related domain; Region: SPOR; pfam05036 762376019304 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 762376019305 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762376019306 DNA binding site [nucleotide binding] 762376019307 active site 762376019308 Predicted methyltransferases [General function prediction only]; Region: COG0313 762376019309 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 762376019310 putative SAM binding site [chemical binding]; other site 762376019311 putative homodimer interface [polypeptide binding]; other site 762376019312 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 762376019313 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 762376019314 dimer interface [polypeptide binding]; other site 762376019315 active site 762376019316 outer membrane lipoprotein; Provisional; Region: PRK11023 762376019317 BON domain; Region: BON; pfam04972 762376019318 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 762376019319 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762376019320 catalytic residues [active] 762376019321 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 762376019322 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762376019323 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 762376019324 homohexameric interface [polypeptide binding]; other site 762376019325 feedback inhibition sensing region; other site 762376019326 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 762376019327 nucleotide binding site [chemical binding]; other site 762376019328 N-acetyl-L-glutamate binding site [chemical binding]; other site 762376019329 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 762376019330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762376019331 motif II; other site 762376019332 division inhibitor protein; Provisional; Region: slmA; PRK09480 762376019333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376019334 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 762376019335 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 762376019336 transmembrane helices; other site 762376019337 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 762376019338 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 762376019339 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 762376019340 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762376019341 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 762376019342 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 762376019343 rod shape-determining protein MreC; Provisional; Region: PRK13922 762376019344 rod shape-determining protein MreC; Region: MreC; pfam04085 762376019345 rod shape-determining protein MreB; Provisional; Region: PRK13927 762376019346 MreB and similar proteins; Region: MreB_like; cd10225 762376019347 nucleotide binding site [chemical binding]; other site 762376019348 Mg binding site [ion binding]; other site 762376019349 putative protofilament interaction site [polypeptide binding]; other site 762376019350 RodZ interaction site [polypeptide binding]; other site 762376019351 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 762376019352 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 762376019353 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376019354 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 762376019355 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 762376019356 GatB domain; Region: GatB_Yqey; smart00845 762376019357 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 762376019358 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 762376019359 putative active site [active] 762376019360 homotetrameric interface [polypeptide binding]; other site 762376019361 metal binding site [ion binding]; metal-binding site 762376019362 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762376019363 active site 762376019364 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 762376019365 putative active site [active] 762376019366 putative catalytic site [active] 762376019367 putative DNA binding site [nucleotide binding]; other site 762376019368 putative phosphate binding site [ion binding]; other site 762376019369 metal binding site A [ion binding]; metal-binding site 762376019370 putative AP binding site [nucleotide binding]; other site 762376019371 putative metal binding site B [ion binding]; other site 762376019372 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376019373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376019374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019375 dimerization interface [polypeptide binding]; other site 762376019376 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 762376019377 glutamate dehydrogenase; Provisional; Region: PRK09414 762376019378 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 762376019379 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 762376019380 NAD(P) binding site [chemical binding]; other site 762376019381 Protein of unknown function (DUF461); Region: DUF461; pfam04314 762376019382 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 762376019383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376019384 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019385 dimerization interface [polypeptide binding]; other site 762376019386 LysE type translocator; Region: LysE; cl00565 762376019387 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 762376019388 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 762376019389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376019390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376019391 dimerization interface [polypeptide binding]; other site 762376019392 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376019393 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 762376019394 putative ligand binding site [chemical binding]; other site 762376019395 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376019396 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376019397 TM-ABC transporter signature motif; other site 762376019398 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376019399 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376019400 TM-ABC transporter signature motif; other site 762376019401 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376019402 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376019403 Walker A/P-loop; other site 762376019404 ATP binding site [chemical binding]; other site 762376019405 Q-loop/lid; other site 762376019406 ABC transporter signature motif; other site 762376019407 Walker B; other site 762376019408 D-loop; other site 762376019409 H-loop/switch region; other site 762376019410 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376019411 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376019412 Walker A/P-loop; other site 762376019413 ATP binding site [chemical binding]; other site 762376019414 Q-loop/lid; other site 762376019415 ABC transporter signature motif; other site 762376019416 Walker B; other site 762376019417 D-loop; other site 762376019418 H-loop/switch region; other site 762376019419 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 762376019420 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376019421 MarR family; Region: MarR; pfam01047 762376019422 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762376019423 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762376019424 ligand binding site [chemical binding]; other site 762376019425 flexible hinge region; other site 762376019426 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 762376019427 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 762376019428 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376019429 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 762376019430 acyl-activating enzyme (AAE) consensus motif; other site 762376019431 putative AMP binding site [chemical binding]; other site 762376019432 putative active site [active] 762376019433 putative CoA binding site [chemical binding]; other site 762376019434 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376019435 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376019436 Walker A/P-loop; other site 762376019437 ATP binding site [chemical binding]; other site 762376019438 Q-loop/lid; other site 762376019439 ABC transporter signature motif; other site 762376019440 Walker B; other site 762376019441 D-loop; other site 762376019442 H-loop/switch region; other site 762376019443 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376019444 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376019445 TM-ABC transporter signature motif; other site 762376019446 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376019447 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376019448 TM-ABC transporter signature motif; other site 762376019449 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 762376019450 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376019451 putative ligand binding site [chemical binding]; other site 762376019452 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376019453 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376019454 Walker A/P-loop; other site 762376019455 ATP binding site [chemical binding]; other site 762376019456 Q-loop/lid; other site 762376019457 ABC transporter signature motif; other site 762376019458 Walker B; other site 762376019459 D-loop; other site 762376019460 H-loop/switch region; other site 762376019461 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 762376019462 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 762376019463 acyl-activating enzyme (AAE) consensus motif; other site 762376019464 AMP binding site [chemical binding]; other site 762376019465 active site 762376019466 CoA binding site [chemical binding]; other site 762376019467 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376019468 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 762376019469 Predicted transporter component [General function prediction only]; Region: COG2391 762376019470 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 762376019471 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376019472 dimerization interface [polypeptide binding]; other site 762376019473 putative DNA binding site [nucleotide binding]; other site 762376019474 putative Zn2+ binding site [ion binding]; other site 762376019475 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 762376019476 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 762376019477 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 762376019478 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 762376019479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376019480 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762376019481 Coenzyme A binding pocket [chemical binding]; other site 762376019482 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 762376019483 nucleotide binding site/active site [active] 762376019484 HIT family signature motif; other site 762376019485 catalytic residue [active] 762376019486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376019487 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 762376019488 putative ADP-binding pocket [chemical binding]; other site 762376019489 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 762376019490 Protein of unknown function, DUF488; Region: DUF488; cl01246 762376019491 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 762376019492 classical (c) SDRs; Region: SDR_c; cd05233 762376019493 NAD(P) binding site [chemical binding]; other site 762376019494 active site 762376019495 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 762376019496 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 762376019497 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 762376019498 N-terminal plug; other site 762376019499 ligand-binding site [chemical binding]; other site 762376019500 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 762376019501 FecR protein; Region: FecR; pfam04773 762376019502 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 762376019503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762376019504 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762376019505 DNA binding residues [nucleotide binding] 762376019506 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 762376019507 ligand binding site [chemical binding]; other site 762376019508 active site 762376019509 UGI interface [polypeptide binding]; other site 762376019510 catalytic site [active] 762376019511 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 762376019512 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 762376019513 ATP binding site [chemical binding]; other site 762376019514 Mg++ binding site [ion binding]; other site 762376019515 motif III; other site 762376019516 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762376019517 nucleotide binding region [chemical binding]; other site 762376019518 ATP-binding site [chemical binding]; other site 762376019519 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 762376019520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762376019521 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13297 762376019522 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 762376019523 active site 762376019524 NTP binding site [chemical binding]; other site 762376019525 metal binding triad [ion binding]; metal-binding site 762376019526 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 762376019527 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 762376019528 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762376019529 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376019530 catalytic residue [active] 762376019531 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 762376019532 Uncharacterized conserved protein [Function unknown]; Region: COG2308 762376019533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 762376019534 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 762376019535 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 762376019536 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 762376019537 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 762376019538 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 762376019539 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 762376019540 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376019541 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376019542 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 762376019543 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376019544 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 762376019545 putative active site [active] 762376019546 putative catalytic site [active] 762376019547 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 762376019548 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376019549 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376019550 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376019551 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 762376019552 FAD binding site [chemical binding]; other site 762376019553 Membrane protein of unknown function; Region: DUF360; pfam04020 762376019554 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 762376019555 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 762376019556 homotetramer interface [polypeptide binding]; other site 762376019557 ligand binding site [chemical binding]; other site 762376019558 catalytic site [active] 762376019559 NAD binding site [chemical binding]; other site 762376019560 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376019561 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 762376019562 Predicted Fe-S protein [General function prediction only]; Region: COG3313 762376019563 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376019564 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 762376019565 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 762376019566 substrate binding site [chemical binding]; other site 762376019567 isopropylmalate isomerase large subunit; Provisional; Region: PRK12466 762376019568 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 762376019569 substrate binding site [chemical binding]; other site 762376019570 ligand binding site [chemical binding]; other site 762376019571 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376019572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376019573 transcriptional activator TtdR; Provisional; Region: PRK09801 762376019574 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 762376019575 putative effector binding pocket; other site 762376019576 putative dimerization interface [polypeptide binding]; other site 762376019577 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376019578 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 762376019579 AsnC family; Region: AsnC_trans_reg; pfam01037 762376019580 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 762376019581 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 762376019582 metabolite-proton symporter; Region: 2A0106; TIGR00883 762376019583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376019584 putative substrate translocation pore; other site 762376019585 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762376019586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376019587 D-loop; other site 762376019588 Amidase; Region: Amidase; cl11426 762376019589 H-loop/switch region; other site 762376019590 S-adenosylmethionine synthetase; Validated; Region: PRK05250 762376019591 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 762376019592 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 762376019593 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 762376019594 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 762376019595 putative acyl-acceptor binding pocket; other site 762376019596 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 762376019597 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 762376019598 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 762376019599 putative acyl-acceptor binding pocket; other site 762376019600 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 762376019601 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 762376019602 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 762376019603 Protein of unknown function, DUF484; Region: DUF484; cl17449 762376019604 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 762376019605 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376019606 active site 762376019607 DNA binding site [nucleotide binding] 762376019608 Int/Topo IB signature motif; other site 762376019609 High-affinity nickel-transport protein; Region: NicO; cl00964 762376019610 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 762376019611 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 762376019612 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 762376019613 metal binding site [ion binding]; metal-binding site 762376019614 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 762376019615 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 762376019616 ABC-ATPase subunit interface; other site 762376019617 putative PBP binding regions; other site 762376019618 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762376019619 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 762376019620 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762376019621 metal binding site 2 [ion binding]; metal-binding site 762376019622 putative DNA binding helix; other site 762376019623 metal binding site 1 [ion binding]; metal-binding site 762376019624 dimer interface [polypeptide binding]; other site 762376019625 structural Zn2+ binding site [ion binding]; other site 762376019626 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 762376019627 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 762376019628 P-loop, Walker A motif; other site 762376019629 Base recognition motif; other site 762376019630 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 762376019631 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 762376019632 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 762376019633 active site 762376019634 HslU subunit interaction site [polypeptide binding]; other site 762376019635 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 762376019636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376019637 Walker A motif; other site 762376019638 ATP binding site [chemical binding]; other site 762376019639 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 762376019640 Walker B motif; other site 762376019641 arginine finger; other site 762376019642 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 762376019643 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 762376019644 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 762376019645 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 762376019646 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 762376019647 NADP binding site [chemical binding]; other site 762376019648 active site 762376019649 putative substrate binding site [chemical binding]; other site 762376019650 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 762376019651 lipoyl synthase; Provisional; Region: PRK05481 762376019652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762376019653 FeS/SAM binding site; other site 762376019654 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762376019655 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376019656 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 762376019657 Sel1-like repeats; Region: SEL1; smart00671 762376019658 Sel1-like repeats; Region: SEL1; smart00671 762376019659 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 762376019660 hypothetical protein; Provisional; Region: PRK02047 762376019661 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 762376019662 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 762376019663 homodimer interface [polypeptide binding]; other site 762376019664 substrate-cofactor binding pocket; other site 762376019665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376019666 catalytic residue [active] 762376019667 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 762376019668 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 762376019669 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 762376019670 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 762376019671 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 762376019672 conserved cys residue [active] 762376019673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376019674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376019675 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762376019676 Zn2+ binding site [ion binding]; other site 762376019677 Mg2+ binding site [ion binding]; other site 762376019678 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762376019679 Protein of unknown function (DUF330); Region: DUF330; cl01135 762376019680 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 762376019681 mce related protein; Region: MCE; pfam02470 762376019682 Arabidopsis broad-spectrum mildew resistance protein RPW8; Region: RPW8; pfam05659 762376019683 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 762376019684 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 762376019685 Walker A/P-loop; other site 762376019686 ATP binding site [chemical binding]; other site 762376019687 Q-loop/lid; other site 762376019688 ABC transporter signature motif; other site 762376019689 Walker B; other site 762376019690 D-loop; other site 762376019691 H-loop/switch region; other site 762376019692 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 762376019693 Permease; Region: Permease; pfam02405 762376019694 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 762376019695 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 762376019696 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 762376019697 pantothenate kinase; Reviewed; Region: PRK13328 762376019698 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 762376019699 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 762376019700 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762376019701 lipopolysaccharide heptosyltransferase I; Region: heptsyl_trn_I; TIGR02193 762376019702 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 762376019703 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 762376019704 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 762376019705 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762376019706 putative trimer interface [polypeptide binding]; other site 762376019707 putative CoA binding site [chemical binding]; other site 762376019708 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 762376019709 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762376019710 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762376019711 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 762376019712 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 762376019713 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 762376019714 putative trimer interface [polypeptide binding]; other site 762376019715 putative active site [active] 762376019716 putative substrate binding site [chemical binding]; other site 762376019717 putative CoA binding site [chemical binding]; other site 762376019718 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 762376019719 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 762376019720 inhibitor-cofactor binding pocket; inhibition site 762376019721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376019722 catalytic residue [active] 762376019723 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 762376019724 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 762376019725 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376019726 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762376019727 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 762376019728 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 762376019729 Ligand Binding Site [chemical binding]; other site 762376019730 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 762376019731 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 762376019732 putative active site [active] 762376019733 oxyanion strand; other site 762376019734 catalytic triad [active] 762376019735 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 762376019736 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 762376019737 substrate binding site [chemical binding]; other site 762376019738 glutamase interaction surface [polypeptide binding]; other site 762376019739 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 762376019740 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 762376019741 NAD(P) binding site [chemical binding]; other site 762376019742 homodimer interface [polypeptide binding]; other site 762376019743 substrate binding site [chemical binding]; other site 762376019744 active site 762376019745 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 762376019746 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 762376019747 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 762376019748 putative NAD(P) binding site [chemical binding]; other site 762376019749 active site 762376019750 putative substrate binding site [chemical binding]; other site 762376019751 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 762376019752 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 762376019753 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 762376019754 active site 762376019755 homodimer interface [polypeptide binding]; other site 762376019756 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762376019757 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 762376019758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019759 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762376019760 NAD(P) binding site [chemical binding]; other site 762376019761 active site 762376019762 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 762376019763 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 762376019764 Mg++ binding site [ion binding]; other site 762376019765 putative catalytic motif [active] 762376019766 putative substrate binding site [chemical binding]; other site 762376019767 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 762376019768 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 762376019769 putative trimer interface [polypeptide binding]; other site 762376019770 putative CoA binding site [chemical binding]; other site 762376019771 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 762376019772 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 762376019773 NAD(P) binding site [chemical binding]; other site 762376019774 homodimer interface [polypeptide binding]; other site 762376019775 substrate binding site [chemical binding]; other site 762376019776 active site 762376019777 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 762376019778 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 762376019779 NAD binding site [chemical binding]; other site 762376019780 substrate binding site [chemical binding]; other site 762376019781 homodimer interface [polypeptide binding]; other site 762376019782 active site 762376019783 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 762376019784 putative hydrophobic ligand binding site [chemical binding]; other site 762376019785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376019786 putative substrate translocation pore; other site 762376019787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376019788 EamA-like transporter family; Region: EamA; pfam00892 762376019789 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762376019790 EamA-like transporter family; Region: EamA; pfam00892 762376019791 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 762376019792 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 762376019793 substrate binding site; other site 762376019794 tetramer interface; other site 762376019795 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 762376019796 Methyltransferase domain; Region: Methyltransf_23; pfam13489 762376019797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376019798 S-adenosylmethionine binding site [chemical binding]; other site 762376019799 Methyltransferase domain; Region: Methyltransf_23; pfam13489 762376019800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376019801 S-adenosylmethionine binding site [chemical binding]; other site 762376019802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376019803 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 762376019804 NAD(P) binding site [chemical binding]; other site 762376019805 active site 762376019806 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 762376019807 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 762376019808 Ligand binding site; other site 762376019809 Putative Catalytic site; other site 762376019810 DXD motif; other site 762376019811 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762376019812 PYR/PP interface [polypeptide binding]; other site 762376019813 dimer interface [polypeptide binding]; other site 762376019814 TPP binding site [chemical binding]; other site 762376019815 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 762376019816 TPP-binding site [chemical binding]; other site 762376019817 dimer interface [polypeptide binding]; other site 762376019818 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 762376019819 putative active site [active] 762376019820 catalytic site [active] 762376019821 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 762376019822 putative active site [active] 762376019823 catalytic site [active] 762376019824 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 762376019825 putative catalytic site [active] 762376019826 putative metal binding site [ion binding]; other site 762376019827 putative phosphate binding site [ion binding]; other site 762376019828 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 762376019829 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 762376019830 dimer interface [polypeptide binding]; other site 762376019831 anticodon binding site; other site 762376019832 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 762376019833 homodimer interface [polypeptide binding]; other site 762376019834 motif 1; other site 762376019835 active site 762376019836 motif 2; other site 762376019837 GAD domain; Region: GAD; pfam02938 762376019838 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 762376019839 motif 3; other site 762376019840 Uncharacterized conserved protein [Function unknown]; Region: COG2928 762376019841 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 762376019842 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 762376019843 Uncharacterized conserved protein [Function unknown]; Region: COG5476 762376019844 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 762376019845 MlrC C-terminus; Region: MlrC_C; pfam07171 762376019846 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376019847 hypothetical protein; Provisional; Region: PRK07483 762376019848 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762376019849 inhibitor-cofactor binding pocket; inhibition site 762376019850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376019851 catalytic residue [active] 762376019852 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762376019853 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 762376019854 putative active site [active] 762376019855 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 762376019856 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 762376019857 dimer interface [polypeptide binding]; other site 762376019858 active site 762376019859 Fatty acid desaturase; Region: FA_desaturase; pfam00487 762376019860 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 762376019861 putative di-iron ligands [ion binding]; other site 762376019862 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 762376019863 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 762376019864 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762376019865 dihydrodipicolinate synthase; Region: dapA; TIGR00674 762376019866 dimer interface [polypeptide binding]; other site 762376019867 active site 762376019868 catalytic residue [active] 762376019869 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 762376019870 GAF domain; Region: GAF_2; pfam13185 762376019871 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 762376019872 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376019873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376019874 homodimer interface [polypeptide binding]; other site 762376019875 catalytic residue [active] 762376019876 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 762376019877 UbiA prenyltransferase family; Region: UbiA; pfam01040 762376019878 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 762376019879 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 762376019880 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 762376019881 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 762376019882 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 762376019883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376019884 DNA-binding site [nucleotide binding]; DNA binding site 762376019885 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 762376019886 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 762376019887 active site 762376019888 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376019889 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 762376019890 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 762376019891 catalytic triad [active] 762376019892 conserved cis-peptide bond; other site 762376019893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376019894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376019895 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 762376019896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376019897 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762376019898 Walker A motif; other site 762376019899 ATP binding site [chemical binding]; other site 762376019900 Walker B motif; other site 762376019901 arginine finger; other site 762376019902 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 762376019903 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 762376019904 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 762376019905 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762376019906 ATP binding site [chemical binding]; other site 762376019907 putative Mg++ binding site [ion binding]; other site 762376019908 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 762376019909 nucleotide binding region [chemical binding]; other site 762376019910 ATP-binding site [chemical binding]; other site 762376019911 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 762376019912 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762376019913 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 762376019914 HsdM N-terminal domain; Region: HsdM_N; pfam12161 762376019915 Methyltransferase domain; Region: Methyltransf_26; pfam13659 762376019916 S-adenosylmethionine binding site [chemical binding]; other site 762376019917 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 762376019918 Domain of unknown function (DUF955); Region: DUF955; cl01076 762376019919 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 762376019920 active site 762376019921 thymidylate synthase; Provisional; Region: thyA; PRK00956 762376019922 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 762376019923 ligand binding site [chemical binding]; other site 762376019924 active site 762376019925 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 762376019926 putative metal binding site [ion binding]; other site 762376019927 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 762376019928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 762376019929 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 762376019930 active site 762376019931 catalytic residues [active] 762376019932 DNA binding site [nucleotide binding] 762376019933 Int/Topo IB signature motif; other site 762376019934 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 762376019935 active site 762376019936 catalytic residues [active] 762376019937 DNA binding site [nucleotide binding] 762376019938 Int/Topo IB signature motif; other site 762376019939 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 762376019940 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762376019941 dimer interface [polypeptide binding]; other site 762376019942 ssDNA binding site [nucleotide binding]; other site 762376019943 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762376019944 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762376019945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376019946 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 762376019947 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762376019948 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762376019949 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 762376019950 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 762376019951 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 762376019952 putative C-terminal domain interface [polypeptide binding]; other site 762376019953 putative GSH binding site (G-site) [chemical binding]; other site 762376019954 putative dimer interface [polypeptide binding]; other site 762376019955 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 762376019956 putative N-terminal domain interface [polypeptide binding]; other site 762376019957 putative dimer interface [polypeptide binding]; other site 762376019958 putative substrate binding pocket (H-site) [chemical binding]; other site 762376019959 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376019960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376019961 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762376019962 dimerization interface [polypeptide binding]; other site 762376019963 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376019964 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376019965 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 762376019966 metal binding site [ion binding]; metal-binding site 762376019967 putative dimer interface [polypeptide binding]; other site 762376019968 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 762376019969 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762376019970 Zn2+ binding site [ion binding]; other site 762376019971 Mg2+ binding site [ion binding]; other site 762376019972 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 762376019973 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 762376019974 active site 762376019975 dimer interface [polypeptide binding]; other site 762376019976 metal binding site [ion binding]; metal-binding site 762376019977 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 762376019978 shikimate kinase; Reviewed; Region: aroK; PRK00131 762376019979 ADP binding site [chemical binding]; other site 762376019980 magnesium binding site [ion binding]; other site 762376019981 putative shikimate binding site; other site 762376019982 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 762376019983 Transglycosylase; Region: Transgly; pfam00912 762376019984 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 762376019985 frataxin-like protein; Provisional; Region: cyaY; PRK00446 762376019986 putative iron binding site [ion binding]; other site 762376019987 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 762376019988 diaminopimelate decarboxylase; Region: lysA; TIGR01048 762376019989 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 762376019990 active site 762376019991 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762376019992 substrate binding site [chemical binding]; other site 762376019993 catalytic residues [active] 762376019994 dimer interface [polypeptide binding]; other site 762376019995 PEGA domain; Region: PEGA; pfam08308 762376019996 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 762376019997 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 762376019998 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 762376019999 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 762376020000 hypothetical protein; Provisional; Region: PRK07033 762376020001 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 762376020002 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 762376020003 ligand binding site [chemical binding]; other site 762376020004 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 762376020005 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 762376020006 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 762376020007 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 762376020008 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 762376020009 phosphopeptide binding site; other site 762376020010 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 762376020011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376020012 Walker A motif; other site 762376020013 ATP binding site [chemical binding]; other site 762376020014 Walker B motif; other site 762376020015 arginine finger; other site 762376020016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376020017 Walker A motif; other site 762376020018 ATP binding site [chemical binding]; other site 762376020019 Walker B motif; other site 762376020020 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762376020021 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 762376020022 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 762376020023 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 762376020024 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 762376020025 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 762376020026 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 762376020027 ImpE protein; Region: ImpE; pfam07024 762376020028 Protein of unknown function (DUF796); Region: DUF796; pfam05638 762376020029 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 762376020030 Protein of unknown function (DUF877); Region: DUF877; pfam05943 762376020031 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 762376020032 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 762376020033 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 762376020034 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 762376020035 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 762376020036 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 762376020037 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 762376020038 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 762376020039 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 762376020040 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376020041 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376020042 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376020043 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376020044 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376020045 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 762376020046 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376020047 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 762376020048 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 762376020049 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 762376020050 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 762376020051 ResB-like family; Region: ResB; pfam05140 762376020052 Cytochrome c553 [Energy production and conversion]; Region: COG2863 762376020053 Cytochrome c; Region: Cytochrom_C; cl11414 762376020054 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 762376020055 G1 box; other site 762376020056 GTP/Mg2+ binding site [chemical binding]; other site 762376020057 Switch I region; other site 762376020058 G2 box; other site 762376020059 G3 box; other site 762376020060 Switch II region; other site 762376020061 G4 box; other site 762376020062 G5 box; other site 762376020063 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 762376020064 dimer interface [polypeptide binding]; other site 762376020065 active site 762376020066 aspartate-rich active site metal binding site; other site 762376020067 allosteric magnesium binding site [ion binding]; other site 762376020068 Schiff base residues; other site 762376020069 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 762376020070 EamA-like transporter family; Region: EamA; pfam00892 762376020071 EamA-like transporter family; Region: EamA; pfam00892 762376020072 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376020073 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376020074 Walker A/P-loop; other site 762376020075 ATP binding site [chemical binding]; other site 762376020076 Q-loop/lid; other site 762376020077 ABC transporter signature motif; other site 762376020078 Walker B; other site 762376020079 D-loop; other site 762376020080 H-loop/switch region; other site 762376020081 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376020082 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376020083 TM-ABC transporter signature motif; other site 762376020084 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376020085 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376020086 Walker A/P-loop; other site 762376020087 ATP binding site [chemical binding]; other site 762376020088 Q-loop/lid; other site 762376020089 ABC transporter signature motif; other site 762376020090 Walker B; other site 762376020091 D-loop; other site 762376020092 H-loop/switch region; other site 762376020093 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376020094 TM-ABC transporter signature motif; other site 762376020095 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376020096 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762376020097 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 762376020098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376020099 NAD(P) binding site [chemical binding]; other site 762376020100 active site 762376020101 putative succinate dehydrogenase; Reviewed; Region: PRK12842 762376020102 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 762376020103 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376020104 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376020105 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376020106 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 762376020107 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 762376020108 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 762376020109 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 762376020110 DsbD alpha interface [polypeptide binding]; other site 762376020111 catalytic residues [active] 762376020112 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 762376020113 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 762376020114 nucleotide binding site/active site [active] 762376020115 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 762376020116 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 762376020117 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 762376020118 alphaNTD homodimer interface [polypeptide binding]; other site 762376020119 alphaNTD - beta interaction site [polypeptide binding]; other site 762376020120 alphaNTD - beta' interaction site [polypeptide binding]; other site 762376020121 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 762376020122 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 762376020123 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 762376020124 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762376020125 RNA binding surface [nucleotide binding]; other site 762376020126 30S ribosomal protein S11; Validated; Region: PRK05309 762376020127 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 762376020128 30S ribosomal protein S13; Region: bact_S13; TIGR03631 762376020129 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 762376020130 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 762376020131 rRNA binding site [nucleotide binding]; other site 762376020132 predicted 30S ribosome binding site; other site 762376020133 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 762376020134 SecY translocase; Region: SecY; pfam00344 762376020135 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 762376020136 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 762376020137 23S rRNA binding site [nucleotide binding]; other site 762376020138 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 762376020139 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 762376020140 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 762376020141 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 762376020142 5S rRNA interface [nucleotide binding]; other site 762376020143 L27 interface [polypeptide binding]; other site 762376020144 23S rRNA interface [nucleotide binding]; other site 762376020145 L5 interface [polypeptide binding]; other site 762376020146 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 762376020147 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762376020148 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762376020149 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 762376020150 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 762376020151 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 762376020152 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 762376020153 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 762376020154 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 762376020155 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 762376020156 RNA binding site [nucleotide binding]; other site 762376020157 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 762376020158 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 762376020159 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376020160 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 762376020161 tetramerization interface [polypeptide binding]; other site 762376020162 NAD(P) binding site [chemical binding]; other site 762376020163 catalytic residues [active] 762376020164 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 762376020165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376020166 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762376020167 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376020168 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 762376020169 putative ligand binding site [chemical binding]; other site 762376020170 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376020171 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376020172 Walker A/P-loop; other site 762376020173 ATP binding site [chemical binding]; other site 762376020174 Q-loop/lid; other site 762376020175 ABC transporter signature motif; other site 762376020176 Walker B; other site 762376020177 D-loop; other site 762376020178 H-loop/switch region; other site 762376020179 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376020180 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376020181 Walker A/P-loop; other site 762376020182 ATP binding site [chemical binding]; other site 762376020183 Q-loop/lid; other site 762376020184 ABC transporter signature motif; other site 762376020185 Walker B; other site 762376020186 D-loop; other site 762376020187 H-loop/switch region; other site 762376020188 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376020189 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376020190 TM-ABC transporter signature motif; other site 762376020191 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376020192 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376020193 TM-ABC transporter signature motif; other site 762376020194 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 762376020195 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 762376020196 23S rRNA interface [nucleotide binding]; other site 762376020197 putative translocon interaction site; other site 762376020198 signal recognition particle (SRP54) interaction site; other site 762376020199 L23 interface [polypeptide binding]; other site 762376020200 trigger factor interaction site; other site 762376020201 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 762376020202 23S rRNA interface [nucleotide binding]; other site 762376020203 5S rRNA interface [nucleotide binding]; other site 762376020204 putative antibiotic binding site [chemical binding]; other site 762376020205 L25 interface [polypeptide binding]; other site 762376020206 L27 interface [polypeptide binding]; other site 762376020207 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 762376020208 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 762376020209 G-X-X-G motif; other site 762376020210 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 762376020211 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 762376020212 putative translocon binding site; other site 762376020213 protein-rRNA interface [nucleotide binding]; other site 762376020214 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 762376020215 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 762376020216 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 762376020217 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 762376020218 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 762376020219 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 762376020220 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 762376020221 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 762376020222 elongation factor Tu; Reviewed; Region: PRK00049 762376020223 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 762376020224 G1 box; other site 762376020225 GEF interaction site [polypeptide binding]; other site 762376020226 GTP/Mg2+ binding site [chemical binding]; other site 762376020227 Switch I region; other site 762376020228 G2 box; other site 762376020229 G3 box; other site 762376020230 Switch II region; other site 762376020231 G4 box; other site 762376020232 G5 box; other site 762376020233 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 762376020234 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 762376020235 Antibiotic Binding Site [chemical binding]; other site 762376020236 elongation factor G; Reviewed; Region: PRK00007 762376020237 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 762376020238 G1 box; other site 762376020239 putative GEF interaction site [polypeptide binding]; other site 762376020240 GTP/Mg2+ binding site [chemical binding]; other site 762376020241 Switch I region; other site 762376020242 G2 box; other site 762376020243 G3 box; other site 762376020244 Switch II region; other site 762376020245 G4 box; other site 762376020246 G5 box; other site 762376020247 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 762376020248 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 762376020249 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 762376020250 30S ribosomal protein S7; Validated; Region: PRK05302 762376020251 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 762376020252 S17 interaction site [polypeptide binding]; other site 762376020253 S8 interaction site; other site 762376020254 16S rRNA interaction site [nucleotide binding]; other site 762376020255 streptomycin interaction site [chemical binding]; other site 762376020256 23S rRNA interaction site [nucleotide binding]; other site 762376020257 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 762376020258 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376020259 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376020260 DNA binding site [nucleotide binding] 762376020261 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762376020262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376020263 active site 762376020264 phosphorylation site [posttranslational modification] 762376020265 intermolecular recognition site; other site 762376020266 dimerization interface [polypeptide binding]; other site 762376020267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376020268 DNA binding site [nucleotide binding] 762376020269 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762376020270 FecR protein; Region: FecR; pfam04773 762376020271 CHASE2 domain; Region: CHASE2; pfam05226 762376020272 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 762376020273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 762376020274 putative active site [active] 762376020275 heme pocket [chemical binding]; other site 762376020276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376020277 dimer interface [polypeptide binding]; other site 762376020278 phosphorylation site [posttranslational modification] 762376020279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376020280 ATP binding site [chemical binding]; other site 762376020281 Mg2+ binding site [ion binding]; other site 762376020282 G-X-G motif; other site 762376020283 PEGA domain; Region: PEGA; pfam08308 762376020284 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 762376020285 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 762376020286 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 762376020287 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 762376020288 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 762376020289 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 762376020290 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 762376020291 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 762376020292 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 762376020293 DNA binding site [nucleotide binding] 762376020294 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 762376020295 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 762376020296 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 762376020297 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 762376020298 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 762376020299 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 762376020300 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 762376020301 RPB3 interaction site [polypeptide binding]; other site 762376020302 RPB1 interaction site [polypeptide binding]; other site 762376020303 RPB11 interaction site [polypeptide binding]; other site 762376020304 RPB10 interaction site [polypeptide binding]; other site 762376020305 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 762376020306 core dimer interface [polypeptide binding]; other site 762376020307 peripheral dimer interface [polypeptide binding]; other site 762376020308 L10 interface [polypeptide binding]; other site 762376020309 L11 interface [polypeptide binding]; other site 762376020310 putative EF-Tu interaction site [polypeptide binding]; other site 762376020311 putative EF-G interaction site [polypeptide binding]; other site 762376020312 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 762376020313 23S rRNA interface [nucleotide binding]; other site 762376020314 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 762376020315 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 762376020316 mRNA/rRNA interface [nucleotide binding]; other site 762376020317 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 762376020318 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 762376020319 23S rRNA interface [nucleotide binding]; other site 762376020320 L7/L12 interface [polypeptide binding]; other site 762376020321 putative thiostrepton binding site; other site 762376020322 L25 interface [polypeptide binding]; other site 762376020323 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 762376020324 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 762376020325 putative homodimer interface [polypeptide binding]; other site 762376020326 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 762376020327 heterodimer interface [polypeptide binding]; other site 762376020328 homodimer interface [polypeptide binding]; other site 762376020329 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 762376020330 elongation factor Tu; Reviewed; Region: PRK00049 762376020331 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 762376020332 G1 box; other site 762376020333 GEF interaction site [polypeptide binding]; other site 762376020334 GTP/Mg2+ binding site [chemical binding]; other site 762376020335 Switch I region; other site 762376020336 G2 box; other site 762376020337 G3 box; other site 762376020338 Switch II region; other site 762376020339 G4 box; other site 762376020340 G5 box; other site 762376020341 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 762376020342 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 762376020343 Antibiotic Binding Site [chemical binding]; other site 762376020344 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 762376020345 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 762376020346 putative active site [active] 762376020347 metal binding site [ion binding]; metal-binding site 762376020348 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762376020349 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 762376020350 NAD(P) binding site [chemical binding]; other site 762376020351 catalytic residues [active] 762376020352 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 762376020353 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 762376020354 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 762376020355 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 762376020356 active site 762376020357 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 762376020358 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762376020359 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762376020360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376020361 Walker A/P-loop; other site 762376020362 ATP binding site [chemical binding]; other site 762376020363 Q-loop/lid; other site 762376020364 ABC transporter signature motif; other site 762376020365 Walker B; other site 762376020366 D-loop; other site 762376020367 H-loop/switch region; other site 762376020368 TOBE domain; Region: TOBE_2; pfam08402 762376020369 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 762376020370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376020371 dimer interface [polypeptide binding]; other site 762376020372 conserved gate region; other site 762376020373 putative PBP binding loops; other site 762376020374 ABC-ATPase subunit interface; other site 762376020375 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 762376020376 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 762376020377 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 762376020378 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376020379 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 762376020380 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762376020381 homodimer interface [polypeptide binding]; other site 762376020382 substrate-cofactor binding pocket; other site 762376020383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376020384 catalytic residue [active] 762376020385 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376020386 active site residue [active] 762376020387 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376020388 active site residue [active] 762376020389 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 762376020390 active site residue [active] 762376020391 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 762376020392 active site residue [active] 762376020393 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 762376020394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376020395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376020396 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 762376020397 putative dimerization interface [polypeptide binding]; other site 762376020398 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 762376020399 active site 762376020400 homotetramer interface [polypeptide binding]; other site 762376020401 homodimer interface [polypeptide binding]; other site 762376020402 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 762376020403 ParB-like nuclease domain; Region: ParB; smart00470 762376020404 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762376020405 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762376020406 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762376020407 P-loop; other site 762376020408 Magnesium ion binding site [ion binding]; other site 762376020409 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762376020410 Magnesium ion binding site [ion binding]; other site 762376020411 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 762376020412 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 762376020413 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 762376020414 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 762376020415 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 762376020416 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762376020417 DNA-binding site [nucleotide binding]; DNA binding site 762376020418 RNA-binding motif; other site 762376020419 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 762376020420 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 762376020421 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 762376020422 methionine aminotransferase; Validated; Region: PRK09082 762376020423 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762376020424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762376020425 homodimer interface [polypeptide binding]; other site 762376020426 catalytic residue [active] 762376020427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 762376020428 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 762376020429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376020430 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 762376020431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762376020432 dimer interface [polypeptide binding]; other site 762376020433 phosphorylation site [posttranslational modification] 762376020434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762376020435 ATP binding site [chemical binding]; other site 762376020436 Mg2+ binding site [ion binding]; other site 762376020437 G-X-G motif; other site 762376020438 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 762376020439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762376020440 active site 762376020441 phosphorylation site [posttranslational modification] 762376020442 intermolecular recognition site; other site 762376020443 dimerization interface [polypeptide binding]; other site 762376020444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762376020445 DNA binding site [nucleotide binding] 762376020446 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 762376020447 Cl- selectivity filter; other site 762376020448 Cl- binding residues [ion binding]; other site 762376020449 pore gating glutamate residue; other site 762376020450 dimer interface [polypeptide binding]; other site 762376020451 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762376020452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762376020453 Coenzyme A binding pocket [chemical binding]; other site 762376020454 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 762376020455 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 762376020456 trmE is a tRNA modification GTPase; Region: trmE; cd04164 762376020457 G1 box; other site 762376020458 GTP/Mg2+ binding site [chemical binding]; other site 762376020459 Switch I region; other site 762376020460 G2 box; other site 762376020461 Switch II region; other site 762376020462 G3 box; other site 762376020463 G4 box; other site 762376020464 G5 box; other site 762376020465 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 762376020466 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 762376020467 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 762376020468 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762376020469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376020470 dimer interface [polypeptide binding]; other site 762376020471 conserved gate region; other site 762376020472 putative PBP binding loops; other site 762376020473 ABC-ATPase subunit interface; other site 762376020474 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762376020475 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 762376020476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762376020477 dimer interface [polypeptide binding]; other site 762376020478 conserved gate region; other site 762376020479 putative PBP binding loops; other site 762376020480 ABC-ATPase subunit interface; other site 762376020481 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762376020482 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376020483 Walker A/P-loop; other site 762376020484 ATP binding site [chemical binding]; other site 762376020485 Q-loop/lid; other site 762376020486 ABC transporter signature motif; other site 762376020487 Walker B; other site 762376020488 D-loop; other site 762376020489 H-loop/switch region; other site 762376020490 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 762376020491 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 762376020492 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762376020493 Walker A/P-loop; other site 762376020494 ATP binding site [chemical binding]; other site 762376020495 Q-loop/lid; other site 762376020496 ABC transporter signature motif; other site 762376020497 Walker B; other site 762376020498 D-loop; other site 762376020499 H-loop/switch region; other site 762376020500 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 762376020501 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762376020502 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 762376020503 metal binding site [ion binding]; metal-binding site 762376020504 putative dimer interface [polypeptide binding]; other site 762376020505 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 762376020506 homotrimer interaction site [polypeptide binding]; other site 762376020507 putative active site [active] 762376020508 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376020509 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 762376020510 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376020511 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376020512 Transcriptional regulators [Transcription]; Region: GntR; COG1802 762376020513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762376020514 DNA-binding site [nucleotide binding]; DNA binding site 762376020515 FCD domain; Region: FCD; pfam07729 762376020516 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 762376020517 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 762376020518 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 762376020519 NMT1-like family; Region: NMT1_2; pfam13379 762376020520 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 762376020521 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 762376020522 Walker A/P-loop; other site 762376020523 ATP binding site [chemical binding]; other site 762376020524 Q-loop/lid; other site 762376020525 ABC transporter signature motif; other site 762376020526 Walker B; other site 762376020527 D-loop; other site 762376020528 H-loop/switch region; other site 762376020529 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762376020530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 762376020531 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 762376020532 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 762376020533 tetramer interface [polypeptide binding]; other site 762376020534 heme binding pocket [chemical binding]; other site 762376020535 NADPH binding site [chemical binding]; other site 762376020536 membrane protein insertase; Provisional; Region: PRK01318 762376020537 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 762376020538 Haemolytic domain; Region: Haemolytic; pfam01809 762376020539 ribonuclease P; Reviewed; Region: rnpA; PRK00038 762376020540 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 762376020541 TrfA protein; Region: TrfA; pfam07042 762376020542 Replication initiator protein A; Region: RPA; cl17860 762376020543 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 762376020544 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762376020545 dimer interface [polypeptide binding]; other site 762376020546 ssDNA binding site [nucleotide binding]; other site 762376020547 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762376020548 conjugal transfer protein TrbA; Provisional; Region: PRK13890 762376020549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376020550 salt bridge; other site 762376020551 non-specific DNA binding site [nucleotide binding]; other site 762376020552 sequence-specific DNA binding site [nucleotide binding]; other site 762376020553 conjugal transfer ATPase TrbB; Provisional; Region: PRK13894 762376020554 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 762376020555 ATP binding site [chemical binding]; other site 762376020556 Walker A motif; other site 762376020557 hexamer interface [polypeptide binding]; other site 762376020558 Walker B motif; other site 762376020559 conjugal transfer protein TrbC; Provisional; Region: PRK13892 762376020560 conjugal transfer protein TrbD; Provisional; Region: PRK13823 762376020561 conjugal transfer protein TrbE; Provisional; Region: PRK13891 762376020562 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 762376020563 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762376020564 Walker A motif; other site 762376020565 ATP binding site [chemical binding]; other site 762376020566 conjugal transfer protein TrbF; Provisional; Region: PRK13887 762376020567 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 762376020568 VirB7 interaction site; other site 762376020569 conjugal transfer protein TrbH; Provisional; Region: PRK13883 762376020570 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 762376020571 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 762376020572 conjugal transfer protein TrbI; Provisional; Region: PRK13881 762376020573 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 762376020574 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 762376020575 conjugal transfer protein TrbJ; Provisional; Region: PRK13879 762376020576 entry exclusion lipoprotein TrbK; Region: TrbK_RP4; TIGR04359 762376020577 P-type conjugative transfer protein TrbL; Region: TrbL_P; TIGR02783 762376020578 conjugal transfer protein TrbM; Provisional; Region: PRK13893 762376020579 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762376020580 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376020581 catalytic residue [active] 762376020582 conjugal transfer protein TrbP; Provisional; Region: PRK13882 762376020583 TraX protein; Region: TraX; pfam05857 762376020584 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 762376020585 ligand binding site [chemical binding]; other site 762376020586 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 762376020587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 762376020588 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 762376020589 DNA binding residues [nucleotide binding] 762376020590 Integrase core domain; Region: rve; pfam00665 762376020591 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 762376020592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376020593 Walker A motif; other site 762376020594 ATP binding site [chemical binding]; other site 762376020595 Walker B motif; other site 762376020596 arginine finger; other site 762376020597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762376020598 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376020599 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 762376020600 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 762376020601 active site 762376020602 dimer interface [polypeptide binding]; other site 762376020603 metal binding site [ion binding]; metal-binding site 762376020604 Dienelactone hydrolase family; Region: DLH; pfam01738 762376020605 Tripartite tricarboxylate transporter family receptor; Region: TctC; pfam03401 762376020606 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 762376020607 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 762376020608 octamer interface [polypeptide binding]; other site 762376020609 active site 762376020610 chlorocatechol 1,2-dioxygenases (1,2-CCDs) (type II enzymes) are homodimeric intradiol dioxygenases that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is part...; Region: 1,2-CCD; cd03462 762376020611 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 762376020612 dimer interface [polypeptide binding]; other site 762376020613 active site 762376020614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376020615 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 762376020616 The C-terminal substrate binding domain of LysR-type transcriptional regulator, CbnR, involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_CbnR; cd08486 762376020617 dimerization interface [polypeptide binding]; other site 762376020618 putative substrate binding pocket [chemical binding]; other site 762376020619 Helix-turn-helix domain; Region: HTH_18; pfam12833 762376020620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376020621 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376020622 YCII-related domain; Region: YCII; pfam03795 762376020623 N-terminal domain of MhqB, a type I extradiol dioxygenase, and similar proteins; Region: MhqB_like_N; cd08344 762376020624 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 762376020625 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762376020626 putative active site [active] 762376020627 putative metal binding site [ion binding]; other site 762376020628 NIPSNAP; Region: NIPSNAP; pfam07978 762376020629 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376020630 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762376020631 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 762376020632 NMT1/THI5 like; Region: NMT1; pfam09084 762376020633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376020634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376020635 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 762376020636 substrate binding pocket [chemical binding]; other site 762376020637 dimerization interface [polypeptide binding]; other site 762376020638 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376020639 Q-loop/lid; other site 762376020640 ABC transporter signature motif; other site 762376020641 Walker B; other site 762376020642 D-loop; other site 762376020643 H-loop/switch region; other site 762376020644 Transposase domain (DUF772); Region: DUF772; pfam05598 762376020645 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 762376020646 DDE superfamily endonuclease; Region: DDE_4; cl17710 762376020647 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 762376020648 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376020649 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376020650 Walker A/P-loop; other site 762376020651 ATP binding site [chemical binding]; other site 762376020652 Q-loop/lid; other site 762376020653 ABC transporter signature motif; other site 762376020654 Walker B; other site 762376020655 D-loop; other site 762376020656 H-loop/switch region; other site 762376020657 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 762376020658 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376020659 TM-ABC transporter signature motif; other site 762376020660 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376020661 TM-ABC transporter signature motif; other site 762376020662 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 762376020663 [2Fe-2S] cluster binding site [ion binding]; other site 762376020664 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376020665 Transposase domain (DUF772); Region: DUF772; pfam05598 762376020666 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 762376020667 DDE superfamily endonuclease; Region: DDE_4; cl17710 762376020668 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 762376020669 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762376020670 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376020671 This alignment model represents the N-terminal rieske iron-sulfur domain of the oxygenase alpha subunit (NagG) of salicylate 5-hydroxylase (S5H). S5H converts salicylate (2-hydroxybenzoate), a metabolic intermediate of phenanthrene, to gentisate (2; Region: Rieske_RO_Alpha_S5H; cd03539 762376020672 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 762376020673 putative alpha subunit interface [polypeptide binding]; other site 762376020674 putative active site [active] 762376020675 putative substrate binding site [chemical binding]; other site 762376020676 Fe binding site [ion binding]; other site 762376020677 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 762376020678 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 762376020679 catalytic loop [active] 762376020680 iron binding site [ion binding]; other site 762376020681 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 762376020682 FAD binding pocket [chemical binding]; other site 762376020683 FAD binding motif [chemical binding]; other site 762376020684 phosphate binding motif [ion binding]; other site 762376020685 beta-alpha-beta structure motif; other site 762376020686 NAD binding pocket [chemical binding]; other site 762376020687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376020688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376020689 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 762376020690 substrate binding pocket [chemical binding]; other site 762376020691 dimerization interface [polypeptide binding]; other site 762376020692 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376020693 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 762376020694 putative ligand binding site [chemical binding]; other site 762376020695 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762376020696 putative DNA binding site [nucleotide binding]; other site 762376020697 putative Zn2+ binding site [ion binding]; other site 762376020698 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 762376020699 inter-subunit interface; other site 762376020700 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 762376020701 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 762376020702 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 762376020703 putative alpha subunit interface [polypeptide binding]; other site 762376020704 putative active site [active] 762376020705 putative substrate binding site [chemical binding]; other site 762376020706 Fe binding site [ion binding]; other site 762376020707 Transposase; Region: DDE_Tnp_ISL3; pfam01610 762376020708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376020709 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762376020710 Walker A motif; other site 762376020711 ATP binding site [chemical binding]; other site 762376020712 Walker B motif; other site 762376020713 Transposase; Region: DDE_Tnp_ISL3; pfam01610 762376020714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 762376020715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 762376020716 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 762376020717 DNA binding residues [nucleotide binding] 762376020718 Integrase core domain; Region: rve; pfam00665 762376020719 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 762376020720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376020721 Walker A motif; other site 762376020722 ATP binding site [chemical binding]; other site 762376020723 Walker B motif; other site 762376020724 arginine finger; other site 762376020725 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 762376020726 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 762376020727 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 762376020728 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 762376020729 Protein of unknown function, DUF462; Region: DUF462; cl01190 762376020730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 762376020731 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 762376020732 active site 762376020733 metal binding site [ion binding]; metal-binding site 762376020734 interdomain interaction site; other site 762376020735 DNA topoisomerase III; Provisional; Region: PRK07726 762376020736 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 762376020737 active site 762376020738 putative interdomain interaction site [polypeptide binding]; other site 762376020739 putative metal-binding site [ion binding]; other site 762376020740 putative nucleotide binding site [chemical binding]; other site 762376020741 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 762376020742 domain I; other site 762376020743 DNA binding groove [nucleotide binding] 762376020744 phosphate binding site [ion binding]; other site 762376020745 domain II; other site 762376020746 domain III; other site 762376020747 nucleotide binding site [chemical binding]; other site 762376020748 catalytic site [active] 762376020749 domain IV; other site 762376020750 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 762376020751 conjugal transfer peptidase TraF; Provisional; Region: PRK13884 762376020752 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 762376020753 conjugal transfer coupling protein TraG; Provisional; Region: PRK13880 762376020754 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762376020755 Walker A motif; other site 762376020756 ATP binding site [chemical binding]; other site 762376020757 Walker B motif; other site 762376020758 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 762376020759 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 762376020760 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 762376020761 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 762376020762 P-loop; other site 762376020763 conjugal transfer protein TraM; Provisional; Region: PRK13895 762376020764 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 762376020765 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 762376020766 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 762376020767 ParB-like nuclease domain; Region: ParB; smart00470 762376020768 KorB domain; Region: KorB; pfam08535 762376020769 KorB C-terminal beta-barrel domain; Region: KorB_C; pfam06613 762376020770 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762376020771 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 762376020772 P-loop; other site 762376020773 Magnesium ion binding site [ion binding]; other site 762376020774 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762376020775 Magnesium ion binding site [ion binding]; other site 762376020776 conjugal transfer protein TrbA; Provisional; Region: PRK13890 762376020777 Protein of unknown function (DUF2761); Region: DUF2761; pfam10959 762376020778 Antirestriction protein; Region: Antirestrict; pfam03230 762376020779 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 762376020780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 762376020781 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 762376020782 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 762376020783 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376020784 active site 762376020785 DNA binding site [nucleotide binding] 762376020786 Int/Topo IB signature motif; other site 762376020787 glycerate kinase; Region: TIGR00045 762376020788 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 762376020789 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 762376020790 active site 762376020791 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376020792 metal-binding site [ion binding] 762376020793 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376020794 metal-binding site [ion binding] 762376020795 Heavy-metal-associated domain; Region: HMA; pfam00403 762376020796 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762376020797 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 762376020798 metal-binding site [ion binding] 762376020799 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762376020800 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 762376020801 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 762376020802 DNA binding residues [nucleotide binding] 762376020803 dimer interface [polypeptide binding]; other site 762376020804 putative metal binding site [ion binding]; other site 762376020805 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 762376020806 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 762376020807 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 762376020808 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 762376020809 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 762376020810 Iron permease FTR1 family; Region: FTR1; cl00475 762376020811 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 762376020812 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 762376020813 Initiator Replication protein; Region: Rep_3; pfam01051 762376020814 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762376020815 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 762376020816 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376020817 active site 762376020818 Int/Topo IB signature motif; other site 762376020819 DNA binding site [nucleotide binding] 762376020820 thiolase; Provisional; Region: PRK06158 762376020821 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376020822 active site 762376020823 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376020824 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376020825 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376020826 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376020827 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376020828 active site 762376020829 catalytic site [active] 762376020830 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 762376020831 active site 762376020832 catalytic site [active] 762376020833 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 762376020834 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376020835 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376020836 Integrase core domain; Region: rve; pfam00665 762376020837 Integrase core domain; Region: rve_3; pfam13683 762376020838 enoyl-CoA hydratase; Provisional; Region: PRK09245 762376020839 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376020840 substrate binding site [chemical binding]; other site 762376020841 oxyanion hole (OAH) forming residues; other site 762376020842 trimer interface [polypeptide binding]; other site 762376020843 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376020844 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376020845 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376020846 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376020847 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376020848 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376020849 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762376020850 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 762376020851 active site 762376020852 FMN binding site [chemical binding]; other site 762376020853 substrate binding site [chemical binding]; other site 762376020854 homotetramer interface [polypeptide binding]; other site 762376020855 catalytic residue [active] 762376020856 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 762376020857 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 762376020858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376020859 NAD(P) binding site [chemical binding]; other site 762376020860 active site 762376020861 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 762376020862 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 762376020863 Walker A/P-loop; other site 762376020864 ATP binding site [chemical binding]; other site 762376020865 Q-loop/lid; other site 762376020866 ABC transporter signature motif; other site 762376020867 Walker B; other site 762376020868 D-loop; other site 762376020869 H-loop/switch region; other site 762376020870 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 762376020871 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 762376020872 Walker A/P-loop; other site 762376020873 ATP binding site [chemical binding]; other site 762376020874 Q-loop/lid; other site 762376020875 ABC transporter signature motif; other site 762376020876 Walker B; other site 762376020877 D-loop; other site 762376020878 H-loop/switch region; other site 762376020879 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376020880 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 762376020881 TM-ABC transporter signature motif; other site 762376020882 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762376020883 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 762376020884 TM-ABC transporter signature motif; other site 762376020885 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 762376020886 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 762376020887 putative ligand binding site [chemical binding]; other site 762376020888 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376020889 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762376020890 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376020891 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376020892 substrate binding site [chemical binding]; other site 762376020893 oxyanion hole (OAH) forming residues; other site 762376020894 trimer interface [polypeptide binding]; other site 762376020895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376020896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376020897 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376020898 dimerization interface [polypeptide binding]; other site 762376020899 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 762376020900 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 762376020901 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 762376020902 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 762376020903 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 762376020904 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762376020905 CoenzymeA binding site [chemical binding]; other site 762376020906 subunit interaction site [polypeptide binding]; other site 762376020907 PHB binding site; other site 762376020908 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376020909 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376020910 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376020911 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 762376020912 Bacterial transcriptional regulator; Region: IclR; pfam01614 762376020913 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 762376020914 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 762376020915 NADP binding site [chemical binding]; other site 762376020916 dimer interface [polypeptide binding]; other site 762376020917 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376020918 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 762376020919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376020920 NAD(P) binding site [chemical binding]; other site 762376020921 active site 762376020922 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376020923 active site 2 [active] 762376020924 active site 1 [active] 762376020925 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376020926 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376020927 active site 762376020928 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376020929 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376020930 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376020931 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376020932 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 762376020933 substrate binding site [chemical binding]; other site 762376020934 oxyanion hole (OAH) forming residues; other site 762376020935 trimer interface [polypeptide binding]; other site 762376020936 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762376020937 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 762376020938 active site 762376020939 FMN binding site [chemical binding]; other site 762376020940 2,4-decadienoyl-CoA binding site; other site 762376020941 catalytic residue [active] 762376020942 4Fe-4S cluster binding site [ion binding]; other site 762376020943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762376020944 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376020945 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376020946 substrate binding site [chemical binding]; other site 762376020947 oxyanion hole (OAH) forming residues; other site 762376020948 trimer interface [polypeptide binding]; other site 762376020949 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762376020950 MarR family; Region: MarR_2; pfam12802 762376020951 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 762376020952 Ligand binding site [chemical binding]; other site 762376020953 Electron transfer flavoprotein domain; Region: ETF; pfam01012 762376020954 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 762376020955 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 762376020956 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 762376020957 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376020958 substrate binding site [chemical binding]; other site 762376020959 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 762376020960 oxyanion hole (OAH) forming residues; other site 762376020961 trimer interface [polypeptide binding]; other site 762376020962 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 762376020963 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376020964 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 762376020965 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 762376020966 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 762376020967 dimer interface [polypeptide binding]; other site 762376020968 active site 762376020969 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 762376020970 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 762376020971 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762376020972 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762376020973 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 762376020974 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762376020975 carboxyltransferase (CT) interaction site; other site 762376020976 biotinylation site [posttranslational modification]; other site 762376020977 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 762376020978 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762376020979 substrate binding site [chemical binding]; other site 762376020980 oxyanion hole (OAH) forming residues; other site 762376020981 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376020982 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376020983 active site 762376020984 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 762376020985 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376020986 CoA binding domain; Region: CoA_binding_2; pfam13380 762376020987 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762376020988 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762376020989 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 762376020990 Transcriptional regulator [Transcription]; Region: IclR; COG1414 762376020991 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376020992 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376020993 thiolase; Provisional; Region: PRK06158 762376020994 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376020995 active site 762376020996 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 762376020997 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 762376020998 active site 762376020999 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 762376021000 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376021001 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376021002 active site 762376021003 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 762376021004 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 762376021005 FMN binding site [chemical binding]; other site 762376021006 substrate binding site [chemical binding]; other site 762376021007 putative catalytic residue [active] 762376021008 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376021009 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 762376021010 CoA-transferase family III; Region: CoA_transf_3; pfam02515 762376021011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762376021012 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 762376021013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762376021014 putative substrate translocation pore; other site 762376021015 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762376021016 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 762376021017 NAD binding site [chemical binding]; other site 762376021018 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762376021019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762376021020 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762376021021 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 762376021022 putative ligand binding site [chemical binding]; other site 762376021023 NAD binding site [chemical binding]; other site 762376021024 catalytic site [active] 762376021025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762376021026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762376021027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762376021028 dimerization interface [polypeptide binding]; other site 762376021029 putative succinate dehydrogenase; Reviewed; Region: PRK12842 762376021030 Predicted oxidoreductase [General function prediction only]; Region: COG3573 762376021031 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 762376021032 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 762376021033 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 762376021034 active site 762376021035 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762376021036 active site 2 [active] 762376021037 active site 1 [active] 762376021038 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 762376021039 CoA binding domain; Region: CoA_binding_2; pfam13380 762376021040 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 762376021041 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 762376021042 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 762376021043 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 762376021044 DUF35 OB-fold domain; Region: DUF35; pfam01796 762376021045 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 762376021046 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 762376021047 active site 762376021048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 762376021049 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 762376021050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762376021051 Walker A motif; other site 762376021052 ATP binding site [chemical binding]; other site 762376021053 Walker B motif; other site 762376021054 arginine finger; other site 762376021055 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 762376021056 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 762376021057 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 762376021058 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 762376021059 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 762376021060 active site 762376021061 DNA binding site [nucleotide binding] 762376021062 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 762376021063 DNA binding site [nucleotide binding] 762376021064 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 762376021065 nucleotide binding site [chemical binding]; other site 762376021066 replicative DNA helicase; Provisional; Region: PRK05973 762376021067 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 762376021068 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762376021069 active site 762376021070 DNA binding site [nucleotide binding] 762376021071 Int/Topo IB signature motif; other site 762376021072 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 762376021073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762376021074 S-adenosylmethionine binding site [chemical binding]; other site 762376021075 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762376021076 Coenzyme A binding pocket [chemical binding]; other site 762376021077 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 762376021078 ParA-like protein; Provisional; Region: PHA02518 762376021079 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 762376021080 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 762376021081 Int/Topo IB signature motif; other site 762376021082 DNA binding site [nucleotide binding] 762376021083 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 762376021084 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 762376021085 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 762376021086 recombination associated protein; Reviewed; Region: rdgC; PRK00321 762376021087 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 762376021088 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 762376021089 cofactor binding site; other site 762376021090 DNA binding site [nucleotide binding] 762376021091 substrate interaction site [chemical binding]; other site 762376021092 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 762376021093 Mrr N-terminal domain; Region: Mrr_N; pfam14338 762376021094 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 762376021095 DNA methylase; Region: N6_N4_Mtase; pfam01555 762376021096 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 762376021097 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 762376021098 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 762376021099 active site 762376021100 substrate binding site [chemical binding]; other site 762376021101 Mg2+ binding site [ion binding]; other site 762376021102 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 762376021103 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 762376021104 AAA-like domain; Region: AAA_10; pfam12846 762376021105 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 762376021106 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 762376021107 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 762376021108 active site 762376021109 catalytic residues [active] 762376021110 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 762376021111 Autotransporter beta-domain; Region: Autotransporter; pfam03797 762376021112 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 762376021113 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 762376021114 Ligand Binding Site [chemical binding]; other site 762376021115 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 762376021116 E3 Ubiquitin ligase; Region: GIDE; pfam12483 762376021117 PilS N terminal; Region: PilS; pfam08805 762376021118 Type II/IV secretion system protein; Region: T2SE; pfam00437 762376021119 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762376021120 Walker A motif; other site 762376021121 ATP binding site [chemical binding]; other site 762376021122 Walker B motif; other site 762376021123 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 762376021124 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 762376021125 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 762376021126 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 762376021127 Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524 762376021128 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762376021129 Walker A motif; other site 762376021130 ATP binding site [chemical binding]; other site 762376021131 Walker B motif; other site 762376021132 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762376021133 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 762376021134 PRTRC system protein D; Region: PRTRC_D; TIGR03739 762376021135 Mg binding site [ion binding]; other site 762376021136 nucleotide binding site [chemical binding]; other site 762376021137 putative protofilament interface [polypeptide binding]; other site 762376021138 Family description; Region: UvrD_C_2; pfam13538 762376021139 translation initiation factor 2; Provisional; Region: infB; CHL00189 762376021140 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 762376021141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376021142 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762376021143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762376021144 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 762376021145 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 762376021146 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 762376021147 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 762376021148 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 762376021149 HipA N-terminal domain; Region: Couple_hipA; pfam13657 762376021150 HipA-like N-terminal domain; Region: HipA_N; pfam07805 762376021151 HipA-like C-terminal domain; Region: HipA_C; pfam07804 762376021152 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376021153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376021154 non-specific DNA binding site [nucleotide binding]; other site 762376021155 salt bridge; other site 762376021156 sequence-specific DNA binding site [nucleotide binding]; other site 762376021157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762376021158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762376021159 non-specific DNA binding site [nucleotide binding]; other site 762376021160 salt bridge; other site 762376021161 sequence-specific DNA binding site [nucleotide binding]; other site 762376021162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 762376021163 HipA N-terminal domain; Region: Couple_hipA; cl11853 762376021164 HipA-like N-terminal domain; Region: HipA_N; pfam07805 762376021165 HipA-like C-terminal domain; Region: HipA_C; pfam07804 762376021166 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 762376021167 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 762376021168 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 762376021169 active site 762376021170 metal binding site [ion binding]; metal-binding site 762376021171 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 762376021172 domain I; other site 762376021173 DNA binding groove [nucleotide binding] 762376021174 phosphate binding site [ion binding]; other site 762376021175 domain II; other site 762376021176 domain III; other site 762376021177 nucleotide binding site [chemical binding]; other site 762376021178 catalytic site [active] 762376021179 domain IV; other site 762376021180 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762376021181 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 762376021182 Helicase_C-like; Region: Helicase_C_4; pfam13871 762376021183 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 762376021184 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 762376021185 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762376021186 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 762376021187 N-acetyl-D-glucosamine binding site [chemical binding]; other site 762376021188 catalytic residue [active] 762376021189 DNA primase, catalytic core; Region: dnaG; TIGR01391 762376021190 CHC2 zinc finger; Region: zf-CHC2; pfam01807 762376021191 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 762376021192 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 762376021193 active site 762376021194 metal binding site [ion binding]; metal-binding site 762376021195 interdomain interaction site; other site 762376021196 H-NS histone family; Region: Histone_HNS; pfam00816 762376021197 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 762376021198 HD domain; Region: HD_3; cl17350 762376021199 ParA-like protein; Provisional; Region: PHA02518 762376021200 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762376021201 P-loop; other site 762376021202 Magnesium ion binding site [ion binding]; other site 762376021203 ParB-like nuclease domain; Region: ParB; smart00470