-- dump date 20140618_184356 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1167634000001 ribonuclease G; Provisional; Region: PRK11712 1167634000002 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1167634000003 homodimer interface [polypeptide binding]; other site 1167634000004 oligonucleotide binding site [chemical binding]; other site 1167634000005 integrase; Provisional; Region: PRK09692 1167634000006 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1167634000007 active site 1167634000008 Int/Topo IB signature motif; other site 1167634000009 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1167634000010 Baseplate J-like protein; Region: Baseplate_J; cl01294 1167634000011 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 1167634000012 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1167634000013 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 1167634000014 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1167634000015 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1167634000016 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1167634000017 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1167634000018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 1167634000019 Terminase-like family; Region: Terminase_6; pfam03237 1167634000020 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1167634000021 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1167634000022 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1167634000023 putative active site [active] 1167634000024 NinB protein; Region: NinB; pfam05772 1167634000025 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1167634000026 ERF superfamily; Region: ERF; pfam04404 1167634000027 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1167634000028 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1167634000029 Methyltransferase domain; Region: Methyltransf_25; pfam13649 1167634000030 Helix-turn-helix domain; Region: HTH_17; cl17695 1167634000031 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1167634000032 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634000033 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634000034 metal binding site [ion binding]; metal-binding site 1167634000035 active site 1167634000036 I-site; other site 1167634000037 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1167634000038 TrkA-N domain; Region: TrkA_N; pfam02254 1167634000039 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1167634000040 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634000041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634000042 Walker A/P-loop; other site 1167634000043 ATP binding site [chemical binding]; other site 1167634000044 Q-loop/lid; other site 1167634000045 ABC transporter signature motif; other site 1167634000046 Walker B; other site 1167634000047 D-loop; other site 1167634000048 H-loop/switch region; other site 1167634000049 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1167634000050 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1167634000051 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1167634000052 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1167634000053 putative active site [active] 1167634000054 Flagellin N-methylase; Region: FliB; cl00497 1167634000055 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634000056 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1167634000057 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1167634000058 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1167634000059 putative active site [active] 1167634000060 putative metal binding site [ion binding]; other site 1167634000061 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634000062 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1167634000063 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1167634000064 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1167634000065 putative metal binding site; other site 1167634000066 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 1167634000067 putative active site [active] 1167634000068 putative metal binding site [ion binding]; other site 1167634000069 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634000070 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1167634000071 putative ADP-binding pocket [chemical binding]; other site 1167634000072 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1167634000073 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1167634000074 putative active site [active] 1167634000075 putative PHP Thumb interface [polypeptide binding]; other site 1167634000076 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1167634000077 generic binding surface I; other site 1167634000078 generic binding surface II; other site 1167634000079 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1167634000080 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1167634000081 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634000082 Walker A/P-loop; other site 1167634000083 ATP binding site [chemical binding]; other site 1167634000084 Q-loop/lid; other site 1167634000085 ABC transporter signature motif; other site 1167634000086 Walker B; other site 1167634000087 D-loop; other site 1167634000088 H-loop/switch region; other site 1167634000089 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1167634000090 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1167634000091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634000092 dimer interface [polypeptide binding]; other site 1167634000093 conserved gate region; other site 1167634000094 putative PBP binding loops; other site 1167634000095 ABC-ATPase subunit interface; other site 1167634000096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634000097 dimer interface [polypeptide binding]; other site 1167634000098 conserved gate region; other site 1167634000099 putative PBP binding loops; other site 1167634000100 ABC-ATPase subunit interface; other site 1167634000101 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1167634000102 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1167634000103 ATP binding site [chemical binding]; other site 1167634000104 putative Mg++ binding site [ion binding]; other site 1167634000105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634000106 nucleotide binding region [chemical binding]; other site 1167634000107 ATP-binding site [chemical binding]; other site 1167634000108 Helicase associated domain (HA2); Region: HA2; pfam04408 1167634000109 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1167634000110 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1167634000111 N-acetylglutamate synthase; Validated; Region: PRK05279 1167634000112 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1167634000113 putative feedback inhibition sensing region; other site 1167634000114 putative nucleotide binding site [chemical binding]; other site 1167634000115 putative substrate binding site [chemical binding]; other site 1167634000116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634000117 Coenzyme A binding pocket [chemical binding]; other site 1167634000118 oxidative damage protection protein; Provisional; Region: PRK05408 1167634000119 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1167634000120 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1167634000121 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1167634000122 transcriptional regulator PhoU; Provisional; Region: PRK11115 1167634000123 PhoU domain; Region: PhoU; pfam01895 1167634000124 PhoU domain; Region: PhoU; pfam01895 1167634000125 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1167634000126 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1167634000127 active site 1167634000128 dimer interface [polypeptide binding]; other site 1167634000129 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1167634000130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634000131 active site 1167634000132 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1167634000133 Amidase; Region: Amidase; cl11426 1167634000134 RmuC family; Region: RmuC; pfam02646 1167634000135 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; pfam10707 1167634000136 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1167634000137 active site 1167634000138 DNA binding site [nucleotide binding] 1167634000139 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1167634000140 ArsC family; Region: ArsC; pfam03960 1167634000141 putative catalytic residues [active] 1167634000142 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1167634000143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634000144 dimer interface [polypeptide binding]; other site 1167634000145 conserved gate region; other site 1167634000146 putative PBP binding loops; other site 1167634000147 ABC-ATPase subunit interface; other site 1167634000148 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1167634000149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634000150 dimer interface [polypeptide binding]; other site 1167634000151 conserved gate region; other site 1167634000152 putative PBP binding loops; other site 1167634000153 ABC-ATPase subunit interface; other site 1167634000154 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1167634000155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634000156 Walker A/P-loop; other site 1167634000157 ATP binding site [chemical binding]; other site 1167634000158 Q-loop/lid; other site 1167634000159 ABC transporter signature motif; other site 1167634000160 Walker B; other site 1167634000161 D-loop; other site 1167634000162 H-loop/switch region; other site 1167634000163 TOBE domain; Region: TOBE_2; pfam08402 1167634000164 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1167634000165 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1167634000166 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 1167634000167 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1167634000168 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1167634000169 apolar tunnel; other site 1167634000170 heme binding site [chemical binding]; other site 1167634000171 dimerization interface [polypeptide binding]; other site 1167634000172 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1167634000173 FtsX-like permease family; Region: FtsX; pfam02687 1167634000174 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1167634000175 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1167634000176 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1167634000177 DctM-like transporters; Region: DctM; pfam06808 1167634000178 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1167634000179 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 1167634000180 acetylornithine aminotransferase; Provisional; Region: PRK02627 1167634000181 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1167634000182 inhibitor-cofactor binding pocket; inhibition site 1167634000183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634000184 catalytic residue [active] 1167634000185 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1167634000186 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1167634000187 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1167634000188 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634000189 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1167634000190 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1167634000191 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634000192 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634000193 active site 1167634000194 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1167634000195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634000196 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1167634000197 putative dimerization interface [polypeptide binding]; other site 1167634000198 argininosuccinate synthase; Validated; Region: PRK05370 1167634000199 argininosuccinate synthase; Provisional; Region: PRK13820 1167634000200 K+ potassium transporter; Region: K_trans; cl15781 1167634000201 potassium uptake protein; Region: kup; TIGR00794 1167634000202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634000203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634000204 dimer interface [polypeptide binding]; other site 1167634000205 phosphorylation site [posttranslational modification] 1167634000206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634000207 ATP binding site [chemical binding]; other site 1167634000208 Mg2+ binding site [ion binding]; other site 1167634000209 G-X-G motif; other site 1167634000210 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634000211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634000212 active site 1167634000213 phosphorylation site [posttranslational modification] 1167634000214 intermolecular recognition site; other site 1167634000215 dimerization interface [polypeptide binding]; other site 1167634000216 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634000217 DNA binding site [nucleotide binding] 1167634000218 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1167634000219 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1167634000220 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1167634000221 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1167634000222 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1167634000223 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1167634000224 IHF dimer interface [polypeptide binding]; other site 1167634000225 IHF - DNA interface [nucleotide binding]; other site 1167634000226 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1167634000227 hypothetical protein; Provisional; Region: PRK05939 1167634000228 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1167634000229 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634000230 catalytic residue [active] 1167634000231 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1167634000232 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1167634000233 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1167634000234 ribonuclease R; Region: RNase_R; TIGR02063 1167634000235 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1167634000236 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1167634000237 RNB domain; Region: RNB; pfam00773 1167634000238 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1167634000239 RNA binding site [nucleotide binding]; other site 1167634000240 DTW domain; Region: DTW; cl01221 1167634000241 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1167634000242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634000243 Coenzyme A binding pocket [chemical binding]; other site 1167634000244 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634000245 EamA-like transporter family; Region: EamA; pfam00892 1167634000246 Predicted permeases [General function prediction only]; Region: COG0679 1167634000247 putative inner membrane protein; Provisional; Region: PRK11099 1167634000248 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1167634000249 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1167634000250 active site 1167634000251 FMN binding site [chemical binding]; other site 1167634000252 substrate binding site [chemical binding]; other site 1167634000253 3Fe-4S cluster binding site [ion binding]; other site 1167634000254 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1167634000255 PLD-like domain; Region: PLDc_2; pfam13091 1167634000256 putative active site [active] 1167634000257 catalytic site [active] 1167634000258 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1167634000259 PLD-like domain; Region: PLDc_2; pfam13091 1167634000260 putative active site [active] 1167634000261 catalytic site [active] 1167634000262 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1167634000263 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1167634000264 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1167634000265 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1167634000266 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1167634000267 aromatic amino acid exporter; Provisional; Region: PRK11689 1167634000268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634000269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634000270 metal binding site [ion binding]; metal-binding site 1167634000271 active site 1167634000272 I-site; other site 1167634000273 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1167634000274 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1167634000275 Baseplate J-like protein; Region: Baseplate_J; cl01294 1167634000276 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1167634000277 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 1167634000278 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1167634000279 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1167634000280 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1167634000281 Predicted transcriptional regulator [Transcription]; Region: COG2932 1167634000282 Catalytic site [active] 1167634000283 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1167634000284 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1167634000285 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1167634000286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634000287 Coenzyme A binding pocket [chemical binding]; other site 1167634000288 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1167634000289 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1167634000290 adenylosuccinate lyase; Provisional; Region: PRK09285 1167634000291 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1167634000292 tetramer interface [polypeptide binding]; other site 1167634000293 active site 1167634000294 putative glutathione S-transferase; Provisional; Region: PRK10357 1167634000295 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1167634000296 putative C-terminal domain interface [polypeptide binding]; other site 1167634000297 putative GSH binding site (G-site) [chemical binding]; other site 1167634000298 putative dimer interface [polypeptide binding]; other site 1167634000299 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1167634000300 dimer interface [polypeptide binding]; other site 1167634000301 N-terminal domain interface [polypeptide binding]; other site 1167634000302 putative substrate binding pocket (H-site) [chemical binding]; other site 1167634000303 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1167634000304 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1167634000305 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1167634000306 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1167634000307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634000308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634000309 dimerization interface [polypeptide binding]; other site 1167634000310 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634000311 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 1167634000312 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1167634000313 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1167634000314 ligand binding site [chemical binding]; other site 1167634000315 homodimer interface [polypeptide binding]; other site 1167634000316 NAD(P) binding site [chemical binding]; other site 1167634000317 trimer interface B [polypeptide binding]; other site 1167634000318 trimer interface A [polypeptide binding]; other site 1167634000319 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1167634000320 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1167634000321 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1167634000322 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1167634000323 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1167634000324 Cysteine-rich domain; Region: CCG; pfam02754 1167634000325 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1167634000326 FAD binding domain; Region: FAD_binding_4; pfam01565 1167634000327 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1167634000328 FAD binding domain; Region: FAD_binding_4; pfam01565 1167634000329 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1167634000330 FAD binding domain; Region: FAD_binding_4; pfam01565 1167634000331 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1167634000332 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1167634000333 protease TldD; Provisional; Region: tldD; PRK10735 1167634000334 H-NS histone family; Region: Histone_HNS; pfam00816 1167634000335 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1167634000336 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1167634000337 aminopeptidase N; Provisional; Region: pepN; PRK14015 1167634000338 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1167634000339 active site 1167634000340 Zn binding site [ion binding]; other site 1167634000341 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1167634000342 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1167634000343 AMP binding site [chemical binding]; other site 1167634000344 metal binding site [ion binding]; metal-binding site 1167634000345 active site 1167634000346 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1167634000347 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1167634000348 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1167634000349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634000350 catalytic residue [active] 1167634000351 homoserine dehydrogenase; Provisional; Region: PRK06349 1167634000352 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1167634000353 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1167634000354 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1167634000355 aminotransferase; Validated; Region: PRK08175 1167634000356 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634000357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634000358 homodimer interface [polypeptide binding]; other site 1167634000359 catalytic residue [active] 1167634000360 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 1167634000361 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1167634000362 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1167634000363 catalytic triad [active] 1167634000364 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1167634000365 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1167634000366 putative active site [active] 1167634000367 PhoH-like protein; Region: PhoH; pfam02562 1167634000368 Predicted small secreted protein [Function unknown]; Region: COG5510 1167634000369 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1167634000370 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1167634000371 Stress responsive A/B Barrel Domain; Region: Dabb; cl17744 1167634000372 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634000373 TM-ABC transporter signature motif; other site 1167634000374 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634000375 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634000376 TM-ABC transporter signature motif; other site 1167634000377 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634000378 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634000379 Walker A/P-loop; other site 1167634000380 ATP binding site [chemical binding]; other site 1167634000381 Q-loop/lid; other site 1167634000382 ABC transporter signature motif; other site 1167634000383 Walker B; other site 1167634000384 D-loop; other site 1167634000385 H-loop/switch region; other site 1167634000386 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634000387 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634000388 Walker A/P-loop; other site 1167634000389 ATP binding site [chemical binding]; other site 1167634000390 Q-loop/lid; other site 1167634000391 ABC transporter signature motif; other site 1167634000392 Walker B; other site 1167634000393 D-loop; other site 1167634000394 H-loop/switch region; other site 1167634000395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634000396 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634000397 NAD(P) binding site [chemical binding]; other site 1167634000398 active site 1167634000399 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1167634000400 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634000401 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1167634000402 putative ligand binding site [chemical binding]; other site 1167634000403 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634000404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634000405 NAD(P) binding site [chemical binding]; other site 1167634000406 active site 1167634000407 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634000408 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1167634000409 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634000410 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1167634000411 dimer interface [polypeptide binding]; other site 1167634000412 substrate binding site [chemical binding]; other site 1167634000413 metal binding sites [ion binding]; metal-binding site 1167634000414 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 1167634000415 HemY protein N-terminus; Region: HemY_N; pfam07219 1167634000416 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1167634000417 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1167634000418 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1167634000419 active site 1167634000420 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1167634000421 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1167634000422 domain interfaces; other site 1167634000423 active site 1167634000424 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1167634000425 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1167634000426 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1167634000427 CoA binding domain; Region: CoA_binding; smart00881 1167634000428 CoA-ligase; Region: Ligase_CoA; pfam00549 1167634000429 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1167634000430 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1167634000431 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1167634000432 CoA-ligase; Region: Ligase_CoA; pfam00549 1167634000433 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 1167634000434 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 1167634000435 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1167634000436 acyl-activating enzyme (AAE) consensus motif; other site 1167634000437 AMP binding site [chemical binding]; other site 1167634000438 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1167634000439 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1167634000440 putative trimer interface [polypeptide binding]; other site 1167634000441 putative CoA binding site [chemical binding]; other site 1167634000442 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1167634000443 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1167634000444 putative trimer interface [polypeptide binding]; other site 1167634000445 putative CoA binding site [chemical binding]; other site 1167634000446 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1167634000447 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1167634000448 THF binding site; other site 1167634000449 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1167634000450 substrate binding site [chemical binding]; other site 1167634000451 THF binding site; other site 1167634000452 zinc-binding site [ion binding]; other site 1167634000453 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1167634000454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634000455 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1167634000456 putative dimerization interface [polypeptide binding]; other site 1167634000457 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1167634000458 recombinase A; Provisional; Region: recA; PRK09354 1167634000459 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1167634000460 hexamer interface [polypeptide binding]; other site 1167634000461 Walker A motif; other site 1167634000462 ATP binding site [chemical binding]; other site 1167634000463 Walker B motif; other site 1167634000464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634000465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634000466 active site 1167634000467 phosphorylation site [posttranslational modification] 1167634000468 intermolecular recognition site; other site 1167634000469 dimerization interface [polypeptide binding]; other site 1167634000470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634000471 DNA binding site [nucleotide binding] 1167634000472 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1167634000473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634000474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634000475 dimer interface [polypeptide binding]; other site 1167634000476 phosphorylation site [posttranslational modification] 1167634000477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634000478 ATP binding site [chemical binding]; other site 1167634000479 G-X-G motif; other site 1167634000480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634000481 putative substrate translocation pore; other site 1167634000482 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1167634000483 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1167634000484 heme-binding site [chemical binding]; other site 1167634000485 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634000486 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634000487 metal binding site [ion binding]; metal-binding site 1167634000488 active site 1167634000489 I-site; other site 1167634000490 aspartate carbamoyltransferase; Provisional; Region: PRK11891 1167634000491 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1167634000492 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1167634000493 ATP-dependent protease La; Region: lon; TIGR00763 1167634000494 Predicted small secreted protein [Function unknown]; Region: COG5510 1167634000495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634000496 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1167634000497 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634000498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634000499 DNA-binding site [nucleotide binding]; DNA binding site 1167634000500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634000501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634000502 homodimer interface [polypeptide binding]; other site 1167634000503 catalytic residue [active] 1167634000504 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1167634000505 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634000506 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1167634000507 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634000508 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1167634000509 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1167634000510 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1167634000511 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1167634000512 replicative DNA helicase; Provisional; Region: PRK07004 1167634000513 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1167634000514 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1167634000515 Walker A motif; other site 1167634000516 ATP binding site [chemical binding]; other site 1167634000517 Walker B motif; other site 1167634000518 DNA binding loops [nucleotide binding] 1167634000519 serine/threonine protein kinase; Provisional; Region: PRK14879 1167634000520 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1167634000521 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1167634000522 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1167634000523 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1167634000524 primosomal replication protein N; Reviewed; Region: PRK00036 1167634000525 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1167634000526 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1167634000527 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1167634000528 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1167634000529 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1167634000530 TPP-binding site; other site 1167634000531 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1167634000532 PYR/PP interface [polypeptide binding]; other site 1167634000533 dimer interface [polypeptide binding]; other site 1167634000534 TPP binding site [chemical binding]; other site 1167634000535 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1167634000536 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1167634000537 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1167634000538 substrate binding pocket [chemical binding]; other site 1167634000539 chain length determination region; other site 1167634000540 substrate-Mg2+ binding site; other site 1167634000541 catalytic residues [active] 1167634000542 aspartate-rich region 1; other site 1167634000543 active site lid residues [active] 1167634000544 aspartate-rich region 2; other site 1167634000545 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1167634000546 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634000547 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1167634000548 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634000549 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1167634000550 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1167634000551 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1167634000552 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1167634000553 [2Fe-2S] cluster binding site [ion binding]; other site 1167634000554 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1167634000555 alpha subunit interface [polypeptide binding]; other site 1167634000556 active site 1167634000557 substrate binding site [chemical binding]; other site 1167634000558 Fe binding site [ion binding]; other site 1167634000559 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1167634000560 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1167634000561 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1167634000562 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1167634000563 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1167634000564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634000565 motif II; other site 1167634000566 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1167634000567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634000568 dimer interface [polypeptide binding]; other site 1167634000569 conserved gate region; other site 1167634000570 putative PBP binding loops; other site 1167634000571 ABC-ATPase subunit interface; other site 1167634000572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634000573 dimer interface [polypeptide binding]; other site 1167634000574 conserved gate region; other site 1167634000575 putative PBP binding loops; other site 1167634000576 ABC-ATPase subunit interface; other site 1167634000577 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1167634000578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634000579 Walker A/P-loop; other site 1167634000580 ATP binding site [chemical binding]; other site 1167634000581 Q-loop/lid; other site 1167634000582 ABC transporter signature motif; other site 1167634000583 Walker B; other site 1167634000584 D-loop; other site 1167634000585 H-loop/switch region; other site 1167634000586 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1167634000587 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634000588 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634000589 dimerization interface [polypeptide binding]; other site 1167634000590 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1167634000591 Zn2+ binding site [ion binding]; other site 1167634000592 Mg2+ binding site [ion binding]; other site 1167634000593 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1167634000594 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1167634000595 active site residue [active] 1167634000596 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1167634000597 active site residue [active] 1167634000598 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634000599 heat shock protein HtpX; Provisional; Region: PRK05457 1167634000600 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1167634000601 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1167634000602 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1167634000603 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1167634000604 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1167634000605 PhoU domain; Region: PhoU; pfam01895 1167634000606 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1167634000607 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1167634000608 DNA polymerase I; Provisional; Region: PRK05755 1167634000609 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1167634000610 active site 1167634000611 putative 5' ssDNA interaction site; other site 1167634000612 metal binding site 3; metal-binding site 1167634000613 metal binding site 1 [ion binding]; metal-binding site 1167634000614 metal binding site 2 [ion binding]; metal-binding site 1167634000615 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1167634000616 putative DNA binding site [nucleotide binding]; other site 1167634000617 putative metal binding site [ion binding]; other site 1167634000618 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1167634000619 active site 1167634000620 catalytic site [active] 1167634000621 substrate binding site [chemical binding]; other site 1167634000622 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1167634000623 active site 1167634000624 DNA binding site [nucleotide binding] 1167634000625 catalytic site [active] 1167634000626 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1167634000627 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1167634000628 amidohydrolase; Region: amidohydrolases; TIGR01891 1167634000629 putative metal binding site [ion binding]; other site 1167634000630 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634000631 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634000632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634000633 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634000634 dimerization interface [polypeptide binding]; other site 1167634000635 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634000636 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634000637 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634000638 dimerization interface [polypeptide binding]; other site 1167634000639 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1167634000640 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1167634000641 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1167634000642 G1 box; other site 1167634000643 putative GEF interaction site [polypeptide binding]; other site 1167634000644 GTP/Mg2+ binding site [chemical binding]; other site 1167634000645 Switch I region; other site 1167634000646 G2 box; other site 1167634000647 G3 box; other site 1167634000648 Switch II region; other site 1167634000649 G4 box; other site 1167634000650 G5 box; other site 1167634000651 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1167634000652 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1167634000653 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1167634000654 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1167634000655 RNA binding site [nucleotide binding]; other site 1167634000656 active site 1167634000657 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1167634000658 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1167634000659 translation initiation factor IF-2; Region: IF-2; TIGR00487 1167634000660 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1167634000661 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1167634000662 G1 box; other site 1167634000663 putative GEF interaction site [polypeptide binding]; other site 1167634000664 GTP/Mg2+ binding site [chemical binding]; other site 1167634000665 Switch I region; other site 1167634000666 G2 box; other site 1167634000667 G3 box; other site 1167634000668 Switch II region; other site 1167634000669 G4 box; other site 1167634000670 G5 box; other site 1167634000671 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1167634000672 Translation-initiation factor 2; Region: IF-2; pfam11987 1167634000673 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1167634000674 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1167634000675 NusA N-terminal domain; Region: NusA_N; pfam08529 1167634000676 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1167634000677 RNA binding site [nucleotide binding]; other site 1167634000678 homodimer interface [polypeptide binding]; other site 1167634000679 NusA-like KH domain; Region: KH_5; pfam13184 1167634000680 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1167634000681 G-X-X-G motif; other site 1167634000682 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1167634000683 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1167634000684 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1167634000685 Sm and related proteins; Region: Sm_like; cl00259 1167634000686 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1167634000687 putative oligomer interface [polypeptide binding]; other site 1167634000688 putative RNA binding site [nucleotide binding]; other site 1167634000689 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1167634000690 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1167634000691 RNA binding surface [nucleotide binding]; other site 1167634000692 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1167634000693 probable active site [active] 1167634000694 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1167634000695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634000696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634000697 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634000698 putative effector binding pocket; other site 1167634000699 dimerization interface [polypeptide binding]; other site 1167634000700 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1167634000701 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1167634000702 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1167634000703 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1167634000704 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1167634000705 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1167634000706 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634000707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634000708 active site 1167634000709 phosphorylation site [posttranslational modification] 1167634000710 intermolecular recognition site; other site 1167634000711 dimerization interface [polypeptide binding]; other site 1167634000712 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634000713 DNA binding site [nucleotide binding] 1167634000714 sensor protein QseC; Provisional; Region: PRK10337 1167634000715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634000716 dimer interface [polypeptide binding]; other site 1167634000717 phosphorylation site [posttranslational modification] 1167634000718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634000719 ATP binding site [chemical binding]; other site 1167634000720 Mg2+ binding site [ion binding]; other site 1167634000721 G-X-G motif; other site 1167634000722 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1167634000723 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1167634000724 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1167634000725 protein binding site [polypeptide binding]; other site 1167634000726 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1167634000727 protein binding site [polypeptide binding]; other site 1167634000728 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1167634000729 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1167634000730 C-terminal domain interface [polypeptide binding]; other site 1167634000731 GSH binding site (G-site) [chemical binding]; other site 1167634000732 putative dimer interface [polypeptide binding]; other site 1167634000733 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1167634000734 dimer interface [polypeptide binding]; other site 1167634000735 N-terminal domain interface [polypeptide binding]; other site 1167634000736 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1167634000737 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1167634000738 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1167634000739 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1167634000740 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1167634000741 hypothetical protein; Reviewed; Region: PRK00024 1167634000742 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1167634000743 MPN+ (JAMM) motif; other site 1167634000744 Zinc-binding site [ion binding]; other site 1167634000745 arylformamidase; Region: trp_arylform; TIGR03035 1167634000746 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1167634000747 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1167634000748 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1167634000749 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1167634000750 cation binding site [ion binding]; other site 1167634000751 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1167634000752 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1167634000753 active site 1167634000754 AMP binding site [chemical binding]; other site 1167634000755 homodimer interface [polypeptide binding]; other site 1167634000756 acyl-activating enzyme (AAE) consensus motif; other site 1167634000757 CoA binding site [chemical binding]; other site 1167634000758 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1167634000759 CoenzymeA binding site [chemical binding]; other site 1167634000760 subunit interaction site [polypeptide binding]; other site 1167634000761 PHB binding site; other site 1167634000762 enoyl-CoA hydratase; Provisional; Region: PRK08140 1167634000763 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634000764 substrate binding site [chemical binding]; other site 1167634000765 oxyanion hole (OAH) forming residues; other site 1167634000766 trimer interface [polypeptide binding]; other site 1167634000767 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 1167634000768 Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Region: ALDH_PAD-PaaZ; cd07127 1167634000769 NADP binding site [chemical binding]; other site 1167634000770 catalytic residues [active] 1167634000771 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1167634000772 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1167634000773 FAD binding pocket [chemical binding]; other site 1167634000774 FAD binding motif [chemical binding]; other site 1167634000775 phosphate binding motif [ion binding]; other site 1167634000776 beta-alpha-beta structure motif; other site 1167634000777 NAD(p) ribose binding residues [chemical binding]; other site 1167634000778 NAD binding pocket [chemical binding]; other site 1167634000779 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1167634000780 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1167634000781 catalytic loop [active] 1167634000782 iron binding site [ion binding]; other site 1167634000783 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1167634000784 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1167634000785 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1167634000786 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1167634000787 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1167634000788 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1167634000789 PaaX-like protein; Region: PaaX; pfam07848 1167634000790 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1167634000791 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1167634000792 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1167634000793 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1167634000794 catalytic site [active] 1167634000795 putative active site [active] 1167634000796 putative substrate binding site [chemical binding]; other site 1167634000797 dimer interface [polypeptide binding]; other site 1167634000798 Peptidase family M48; Region: Peptidase_M48; pfam01435 1167634000799 GTPase RsgA; Reviewed; Region: PRK00098 1167634000800 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1167634000801 RNA binding site [nucleotide binding]; other site 1167634000802 homodimer interface [polypeptide binding]; other site 1167634000803 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1167634000804 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1167634000805 GTP/Mg2+ binding site [chemical binding]; other site 1167634000806 G4 box; other site 1167634000807 G5 box; other site 1167634000808 G1 box; other site 1167634000809 Switch I region; other site 1167634000810 G2 box; other site 1167634000811 G3 box; other site 1167634000812 Switch II region; other site 1167634000813 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1167634000814 putative active site [active] 1167634000815 putative CoA binding site [chemical binding]; other site 1167634000816 nudix motif; other site 1167634000817 metal binding site [ion binding]; metal-binding site 1167634000818 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1167634000819 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1167634000820 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1167634000821 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1167634000822 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1167634000823 CysD dimerization site [polypeptide binding]; other site 1167634000824 G1 box; other site 1167634000825 putative GEF interaction site [polypeptide binding]; other site 1167634000826 GTP/Mg2+ binding site [chemical binding]; other site 1167634000827 Switch I region; other site 1167634000828 G2 box; other site 1167634000829 G3 box; other site 1167634000830 Switch II region; other site 1167634000831 G4 box; other site 1167634000832 G5 box; other site 1167634000833 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1167634000834 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1167634000835 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1167634000836 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1167634000837 Active Sites [active] 1167634000838 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1167634000839 Active Sites [active] 1167634000840 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1167634000841 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1167634000842 Walker A/P-loop; other site 1167634000843 ATP binding site [chemical binding]; other site 1167634000844 Q-loop/lid; other site 1167634000845 ABC transporter signature motif; other site 1167634000846 Walker B; other site 1167634000847 D-loop; other site 1167634000848 H-loop/switch region; other site 1167634000849 TOBE-like domain; Region: TOBE_3; pfam12857 1167634000850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634000851 dimer interface [polypeptide binding]; other site 1167634000852 conserved gate region; other site 1167634000853 putative PBP binding loops; other site 1167634000854 ABC-ATPase subunit interface; other site 1167634000855 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1167634000856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634000857 dimer interface [polypeptide binding]; other site 1167634000858 conserved gate region; other site 1167634000859 putative PBP binding loops; other site 1167634000860 ABC-ATPase subunit interface; other site 1167634000861 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1167634000862 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1167634000863 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1167634000864 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1167634000865 dimer interface [polypeptide binding]; other site 1167634000866 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1167634000867 catalytic triad [active] 1167634000868 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1167634000869 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1167634000870 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634000871 active site 1167634000872 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1167634000873 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1167634000874 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1167634000875 TrkA-C domain; Region: TrkA_C; pfam02080 1167634000876 TrkA-C domain; Region: TrkA_C; pfam02080 1167634000877 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1167634000878 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1167634000879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634000880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634000881 homodimer interface [polypeptide binding]; other site 1167634000882 catalytic residue [active] 1167634000883 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1167634000884 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1167634000885 TrkA-C domain; Region: TrkA_C; pfam02080 1167634000886 TrkA-C domain; Region: TrkA_C; pfam02080 1167634000887 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1167634000888 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1167634000889 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1167634000890 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1167634000891 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1167634000892 Ligand binding site [chemical binding]; other site 1167634000893 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1167634000894 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1167634000895 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1167634000896 putative active site [active] 1167634000897 Zn binding site [ion binding]; other site 1167634000898 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1167634000899 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1167634000900 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1167634000901 Putative cyclase; Region: Cyclase; cl00814 1167634000902 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1167634000903 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634000904 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634000905 cysteine synthase B; Region: cysM; TIGR01138 1167634000906 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1167634000907 dimer interface [polypeptide binding]; other site 1167634000908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634000909 catalytic residue [active] 1167634000910 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1167634000911 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1167634000912 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1167634000913 NADP binding site [chemical binding]; other site 1167634000914 homopentamer interface [polypeptide binding]; other site 1167634000915 substrate binding site [chemical binding]; other site 1167634000916 active site 1167634000917 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1167634000918 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1167634000919 putative ribose interaction site [chemical binding]; other site 1167634000920 putative ADP binding site [chemical binding]; other site 1167634000921 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1167634000922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1167634000923 binding surface 1167634000924 TPR motif; other site 1167634000925 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1167634000926 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1167634000927 IHF dimer interface [polypeptide binding]; other site 1167634000928 IHF - DNA interface [nucleotide binding]; other site 1167634000929 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1167634000930 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1167634000931 RNA binding site [nucleotide binding]; other site 1167634000932 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1167634000933 RNA binding site [nucleotide binding]; other site 1167634000934 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1167634000935 RNA binding site [nucleotide binding]; other site 1167634000936 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1167634000937 RNA binding site [nucleotide binding]; other site 1167634000938 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1167634000939 RNA binding site [nucleotide binding]; other site 1167634000940 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1167634000941 RNA binding site [nucleotide binding]; other site 1167634000942 cytidylate kinase; Provisional; Region: cmk; PRK00023 1167634000943 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1167634000944 CMP-binding site; other site 1167634000945 The sites determining sugar specificity; other site 1167634000946 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1167634000947 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1167634000948 hinge; other site 1167634000949 active site 1167634000950 prephenate dehydrogenase; Validated; Region: PRK08507 1167634000951 Prephenate dehydrogenase; Region: PDH; pfam02153 1167634000952 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1167634000953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634000954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634000955 homodimer interface [polypeptide binding]; other site 1167634000956 catalytic residue [active] 1167634000957 Chorismate mutase type II; Region: CM_2; cl00693 1167634000958 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1167634000959 Prephenate dehydratase; Region: PDT; pfam00800 1167634000960 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1167634000961 putative L-Phe binding site [chemical binding]; other site 1167634000962 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1167634000963 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634000964 catalytic residue [active] 1167634000965 DNA gyrase subunit A; Validated; Region: PRK05560 1167634000966 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1167634000967 CAP-like domain; other site 1167634000968 active site 1167634000969 primary dimer interface [polypeptide binding]; other site 1167634000970 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1167634000971 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1167634000972 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1167634000973 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1167634000974 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1167634000975 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1167634000976 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1167634000977 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1167634000978 ligand binding site [chemical binding]; other site 1167634000979 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1167634000980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634000981 S-adenosylmethionine binding site [chemical binding]; other site 1167634000982 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1167634000983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634000984 motif II; other site 1167634000985 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1167634000986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634000987 putative substrate translocation pore; other site 1167634000988 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1167634000989 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1167634000990 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1167634000991 active site 1167634000992 homodimer interface [polypeptide binding]; other site 1167634000993 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1167634000994 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 1167634000995 active site 1167634000996 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1167634000997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1167634000998 binding surface 1167634000999 TPR motif; other site 1167634001000 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 1167634001001 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1167634001002 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1167634001003 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1167634001004 acyl-activating enzyme (AAE) consensus motif; other site 1167634001005 AMP binding site [chemical binding]; other site 1167634001006 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 1167634001007 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634001008 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634001009 active site 1167634001010 hypothetical protein; Provisional; Region: PRK09936 1167634001011 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 1167634001012 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1167634001013 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1167634001014 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1167634001015 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1167634001016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1167634001017 MOSC domain; Region: MOSC; pfam03473 1167634001018 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1167634001019 dinuclear metal binding motif [ion binding]; other site 1167634001020 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1167634001021 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1167634001022 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 1167634001023 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634001024 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1167634001025 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1167634001026 Walker A/P-loop; other site 1167634001027 ATP binding site [chemical binding]; other site 1167634001028 Q-loop/lid; other site 1167634001029 ABC transporter signature motif; other site 1167634001030 Walker B; other site 1167634001031 D-loop; other site 1167634001032 H-loop/switch region; other site 1167634001033 cyanophycin synthetase; Provisional; Region: PRK14016 1167634001034 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1167634001035 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1167634001036 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1167634001037 cyanophycin synthetase; Provisional; Region: PRK14016 1167634001038 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1167634001039 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1167634001040 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1167634001041 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1167634001042 CsbD-like; Region: CsbD; cl17424 1167634001043 BON domain; Region: BON; pfam04972 1167634001044 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1167634001045 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1167634001046 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 1167634001047 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1167634001048 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1167634001049 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1167634001050 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1167634001051 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1167634001052 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1167634001053 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 1167634001054 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1167634001055 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1167634001056 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1167634001057 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1167634001058 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1167634001059 Iron permease FTR1 family; Region: FTR1; cl00475 1167634001060 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1167634001061 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1167634001062 Fe2+ transport protein; Region: Iron_transport; pfam10634 1167634001063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 1167634001064 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1167634001065 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1167634001066 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1167634001067 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1167634001068 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1167634001069 NAD(P) binding site [chemical binding]; other site 1167634001070 homotetramer interface [polypeptide binding]; other site 1167634001071 homodimer interface [polypeptide binding]; other site 1167634001072 active site 1167634001073 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1167634001074 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1167634001075 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1167634001076 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1167634001077 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1167634001078 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1167634001079 RNA binding surface [nucleotide binding]; other site 1167634001080 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1167634001081 active site 1167634001082 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1167634001083 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1167634001084 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1167634001085 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1167634001086 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1167634001087 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1167634001088 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1167634001089 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1167634001090 RNA binding site [nucleotide binding]; other site 1167634001091 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 1167634001092 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1167634001093 active site 1167634001094 HIGH motif; other site 1167634001095 dimer interface [polypeptide binding]; other site 1167634001096 KMSKS motif; other site 1167634001097 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1167634001098 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1167634001099 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1167634001100 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1167634001101 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1167634001102 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1167634001103 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634001104 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1167634001105 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634001106 N-terminal plug; other site 1167634001107 ligand-binding site [chemical binding]; other site 1167634001108 fec operon regulator FecR; Reviewed; Region: PRK09774 1167634001109 FecR protein; Region: FecR; pfam04773 1167634001110 RNA polymerase sigma factor; Provisional; Region: PRK12528 1167634001111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634001112 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634001113 DNA binding residues [nucleotide binding] 1167634001114 Predicted ATPase [General function prediction only]; Region: COG1485 1167634001115 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1167634001116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634001117 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1167634001118 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1167634001119 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1167634001120 E3 interaction surface; other site 1167634001121 lipoyl attachment site [posttranslational modification]; other site 1167634001122 e3 binding domain; Region: E3_binding; pfam02817 1167634001123 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1167634001124 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1167634001125 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1167634001126 TPP-binding site [chemical binding]; other site 1167634001127 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1167634001128 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1167634001129 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634001130 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1167634001131 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1167634001132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634001133 catalytic residue [active] 1167634001134 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1167634001135 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1167634001136 active site 1167634001137 catalytic site [active] 1167634001138 tetramer interface [polypeptide binding]; other site 1167634001139 putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590 1167634001140 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 1167634001141 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1167634001142 active site 1167634001143 metal binding site [ion binding]; metal-binding site 1167634001144 dimer interface [polypeptide binding]; other site 1167634001145 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 1167634001146 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 1167634001147 putative metal binding site [ion binding]; other site 1167634001148 Predicted membrane protein [Function unknown]; Region: COG1297 1167634001149 putative oligopeptide transporter, OPT family; Region: TIGR00733 1167634001150 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 1167634001151 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1167634001152 dimer interface [polypeptide binding]; other site 1167634001153 TPP-binding site [chemical binding]; other site 1167634001154 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1167634001155 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1167634001156 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1167634001157 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1167634001158 putative NAD(P) binding site [chemical binding]; other site 1167634001159 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1167634001160 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 1167634001161 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1167634001162 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1167634001163 dimer interface [polypeptide binding]; other site 1167634001164 active site 1167634001165 citrylCoA binding site [chemical binding]; other site 1167634001166 NADH binding [chemical binding]; other site 1167634001167 cationic pore residues; other site 1167634001168 oxalacetate/citrate binding site [chemical binding]; other site 1167634001169 coenzyme A binding site [chemical binding]; other site 1167634001170 catalytic triad [active] 1167634001171 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1167634001172 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1167634001173 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 1167634001174 L-aspartate oxidase; Provisional; Region: PRK06175 1167634001175 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1167634001176 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1167634001177 SdhC subunit interface [polypeptide binding]; other site 1167634001178 proximal heme binding site [chemical binding]; other site 1167634001179 cardiolipin binding site; other site 1167634001180 Iron-sulfur protein interface; other site 1167634001181 proximal quinone binding site [chemical binding]; other site 1167634001182 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1167634001183 Iron-sulfur protein interface; other site 1167634001184 proximal quinone binding site [chemical binding]; other site 1167634001185 SdhD (CybS) interface [polypeptide binding]; other site 1167634001186 proximal heme binding site [chemical binding]; other site 1167634001187 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1167634001188 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634001189 DNA-binding site [nucleotide binding]; DNA binding site 1167634001190 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1167634001191 malate dehydrogenase; Provisional; Region: PRK05442 1167634001192 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1167634001193 NAD(P) binding site [chemical binding]; other site 1167634001194 dimer interface [polypeptide binding]; other site 1167634001195 malate binding site [chemical binding]; other site 1167634001196 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1167634001197 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1167634001198 tetramer interface [polypeptide binding]; other site 1167634001199 active site 1167634001200 Mg2+/Mn2+ binding site [ion binding]; other site 1167634001201 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1167634001202 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1167634001203 dimer interface [polypeptide binding]; other site 1167634001204 active site 1167634001205 citrylCoA binding site [chemical binding]; other site 1167634001206 oxalacetate/citrate binding site [chemical binding]; other site 1167634001207 coenzyme A binding site [chemical binding]; other site 1167634001208 catalytic triad [active] 1167634001209 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1167634001210 Predicted membrane protein [Function unknown]; Region: COG1981 1167634001211 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1167634001212 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1167634001213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634001214 RDD family; Region: RDD; pfam06271 1167634001215 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 1167634001216 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1167634001217 active site 1167634001218 putative substrate binding region [chemical binding]; other site 1167634001219 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1167634001220 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1167634001221 putative active site [active] 1167634001222 putative metal binding site [ion binding]; other site 1167634001223 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1167634001224 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 1167634001225 active site 1167634001226 acyl-activating enzyme (AAE) consensus motif; other site 1167634001227 putative CoA binding site [chemical binding]; other site 1167634001228 AMP binding site [chemical binding]; other site 1167634001229 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1167634001230 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1167634001231 trimer interface [polypeptide binding]; other site 1167634001232 putative metal binding site [ion binding]; other site 1167634001233 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1167634001234 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1167634001235 dimerization interface [polypeptide binding]; other site 1167634001236 domain crossover interface; other site 1167634001237 redox-dependent activation switch; other site 1167634001238 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1167634001239 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1167634001240 enolase; Provisional; Region: eno; PRK00077 1167634001241 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1167634001242 dimer interface [polypeptide binding]; other site 1167634001243 metal binding site [ion binding]; metal-binding site 1167634001244 substrate binding pocket [chemical binding]; other site 1167634001245 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1167634001246 CTP synthetase; Validated; Region: pyrG; PRK05380 1167634001247 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1167634001248 Catalytic site [active] 1167634001249 active site 1167634001250 UTP binding site [chemical binding]; other site 1167634001251 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1167634001252 active site 1167634001253 putative oxyanion hole; other site 1167634001254 catalytic triad [active] 1167634001255 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1167634001256 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1167634001257 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1167634001258 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1167634001259 active site 1167634001260 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 1167634001261 SxDxEG motif; other site 1167634001262 active site 1167634001263 metal binding site [ion binding]; metal-binding site 1167634001264 homopentamer interface [polypeptide binding]; other site 1167634001265 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1167634001266 homodimer interface [polypeptide binding]; other site 1167634001267 homotetramer interface [polypeptide binding]; other site 1167634001268 active site pocket [active] 1167634001269 cleavage site 1167634001270 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1167634001271 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1167634001272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634001273 dimer interface [polypeptide binding]; other site 1167634001274 conserved gate region; other site 1167634001275 putative PBP binding loops; other site 1167634001276 ABC-ATPase subunit interface; other site 1167634001277 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1167634001278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634001279 dimer interface [polypeptide binding]; other site 1167634001280 conserved gate region; other site 1167634001281 putative PBP binding loops; other site 1167634001282 ABC-ATPase subunit interface; other site 1167634001283 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1167634001284 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1167634001285 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1167634001286 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634001287 Walker A/P-loop; other site 1167634001288 ATP binding site [chemical binding]; other site 1167634001289 Q-loop/lid; other site 1167634001290 ABC transporter signature motif; other site 1167634001291 Walker B; other site 1167634001292 D-loop; other site 1167634001293 H-loop/switch region; other site 1167634001294 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634001295 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634001296 Walker A/P-loop; other site 1167634001297 ATP binding site [chemical binding]; other site 1167634001298 Q-loop/lid; other site 1167634001299 ABC transporter signature motif; other site 1167634001300 Walker B; other site 1167634001301 D-loop; other site 1167634001302 H-loop/switch region; other site 1167634001303 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634001304 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1167634001305 catalytic nucleophile [active] 1167634001306 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1167634001307 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1167634001308 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1167634001309 putative active site [active] 1167634001310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634001311 Coenzyme A binding pocket [chemical binding]; other site 1167634001312 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1167634001313 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1167634001314 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1167634001315 active site 1167634001316 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1167634001317 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1167634001318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634001319 NAD(P) binding site [chemical binding]; other site 1167634001320 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1167634001321 active site 1167634001322 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1167634001323 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634001324 DNA-binding site [nucleotide binding]; DNA binding site 1167634001325 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634001326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1167634001327 DNA-binding site [nucleotide binding]; DNA binding site 1167634001328 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1167634001329 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1167634001330 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1167634001331 inhibitor-cofactor binding pocket; inhibition site 1167634001332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634001333 catalytic residue [active] 1167634001334 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1167634001335 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1167634001336 tetramer interface [polypeptide binding]; other site 1167634001337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634001338 catalytic residue [active] 1167634001339 EamA-like transporter family; Region: EamA; pfam00892 1167634001340 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1167634001341 EamA-like transporter family; Region: EamA; pfam00892 1167634001342 acetyl-CoA synthetase; Provisional; Region: PRK00174 1167634001343 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1167634001344 active site 1167634001345 CoA binding site [chemical binding]; other site 1167634001346 acyl-activating enzyme (AAE) consensus motif; other site 1167634001347 AMP binding site [chemical binding]; other site 1167634001348 acetate binding site [chemical binding]; other site 1167634001349 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1167634001350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634001351 putative substrate translocation pore; other site 1167634001352 Domain of unknown function (DUF336); Region: DUF336; cl01249 1167634001353 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1167634001354 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634001355 acyl-activating enzyme (AAE) consensus motif; other site 1167634001356 AMP binding site [chemical binding]; other site 1167634001357 active site 1167634001358 CoA binding site [chemical binding]; other site 1167634001359 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1167634001360 NlpC/P60 family; Region: NLPC_P60; pfam00877 1167634001361 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 1167634001362 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 1167634001363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634001364 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1167634001365 substrate binding site [chemical binding]; other site 1167634001366 dimerization interface [polypeptide binding]; other site 1167634001367 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1167634001368 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1167634001369 tetrameric interface [polypeptide binding]; other site 1167634001370 NAD binding site [chemical binding]; other site 1167634001371 catalytic residues [active] 1167634001372 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634001373 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1167634001374 putative ligand binding site [chemical binding]; other site 1167634001375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634001376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634001377 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634001378 dimerization interface [polypeptide binding]; other site 1167634001379 Predicted permeases [General function prediction only]; Region: COG0795 1167634001380 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1167634001381 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1167634001382 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1167634001383 interface (dimer of trimers) [polypeptide binding]; other site 1167634001384 Substrate-binding/catalytic site; other site 1167634001385 Zn-binding sites [ion binding]; other site 1167634001386 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 1167634001387 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1167634001388 YccA-like proteins; Region: YccA_like; cd10433 1167634001389 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1167634001390 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1167634001391 active site 1167634001392 catalytic tetrad [active] 1167634001393 TLC ATP/ADP transporter; Region: TLC; cl03940 1167634001394 TLC ATP/ADP transporter; Region: TLC; cl03940 1167634001395 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634001396 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1167634001397 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1167634001398 active site 1167634001399 Zn binding site [ion binding]; other site 1167634001400 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1167634001401 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1167634001402 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634001403 catalytic residue [active] 1167634001404 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1167634001405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634001406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634001407 dimerization interface [polypeptide binding]; other site 1167634001408 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1167634001409 Recombination protein O N terminal; Region: RecO_N; pfam11967 1167634001410 Recombination protein O C terminal; Region: RecO_C; pfam02565 1167634001411 GTPase Era; Reviewed; Region: era; PRK00089 1167634001412 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1167634001413 G1 box; other site 1167634001414 GTP/Mg2+ binding site [chemical binding]; other site 1167634001415 Switch I region; other site 1167634001416 G2 box; other site 1167634001417 Switch II region; other site 1167634001418 G3 box; other site 1167634001419 G4 box; other site 1167634001420 G5 box; other site 1167634001421 KH domain; Region: KH_2; pfam07650 1167634001422 ribonuclease III; Reviewed; Region: rnc; PRK00102 1167634001423 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1167634001424 dimerization interface [polypeptide binding]; other site 1167634001425 active site 1167634001426 metal binding site [ion binding]; metal-binding site 1167634001427 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1167634001428 signal peptidase I; Provisional; Region: PRK10861 1167634001429 HemY protein N-terminus; Region: HemY_N; pfam07219 1167634001430 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1167634001431 Catalytic site [active] 1167634001432 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1167634001433 GTP-binding protein LepA; Provisional; Region: PRK05433 1167634001434 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1167634001435 G1 box; other site 1167634001436 putative GEF interaction site [polypeptide binding]; other site 1167634001437 GTP/Mg2+ binding site [chemical binding]; other site 1167634001438 Switch I region; other site 1167634001439 G2 box; other site 1167634001440 G3 box; other site 1167634001441 Switch II region; other site 1167634001442 G4 box; other site 1167634001443 G5 box; other site 1167634001444 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1167634001445 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1167634001446 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1167634001447 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1167634001448 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1167634001449 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1167634001450 protein binding site [polypeptide binding]; other site 1167634001451 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1167634001452 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1167634001453 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1167634001454 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1167634001455 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1167634001456 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634001457 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634001458 DNA binding residues [nucleotide binding] 1167634001459 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1167634001460 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1167634001461 dimer interface [polypeptide binding]; other site 1167634001462 active site 1167634001463 acyl carrier protein; Provisional; Region: acpP; PRK00982 1167634001464 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1167634001465 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1167634001466 NAD(P) binding site [chemical binding]; other site 1167634001467 homotetramer interface [polypeptide binding]; other site 1167634001468 homodimer interface [polypeptide binding]; other site 1167634001469 active site 1167634001470 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1167634001471 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1167634001472 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1167634001473 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1167634001474 dimer interface [polypeptide binding]; other site 1167634001475 active site 1167634001476 CoA binding pocket [chemical binding]; other site 1167634001477 putative phosphate acyltransferase; Provisional; Region: PRK05331 1167634001478 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1167634001479 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1167634001480 Maf-like protein; Region: Maf; pfam02545 1167634001481 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1167634001482 active site 1167634001483 dimer interface [polypeptide binding]; other site 1167634001484 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 1167634001485 putative SAM binding site [chemical binding]; other site 1167634001486 homodimer interface [polypeptide binding]; other site 1167634001487 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1167634001488 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1167634001489 amidase catalytic site [active] 1167634001490 Zn binding residues [ion binding]; other site 1167634001491 substrate binding site [chemical binding]; other site 1167634001492 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1167634001493 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1167634001494 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1167634001495 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1167634001496 Moco binding site; other site 1167634001497 metal coordination site [ion binding]; other site 1167634001498 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1167634001499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634001500 motif II; other site 1167634001501 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1167634001502 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1167634001503 RNA binding surface [nucleotide binding]; other site 1167634001504 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1167634001505 active site 1167634001506 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1167634001507 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1167634001508 homodimer interface [polypeptide binding]; other site 1167634001509 oligonucleotide binding site [chemical binding]; other site 1167634001510 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1167634001511 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1167634001512 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1167634001513 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1167634001514 substrate binding site [chemical binding]; other site 1167634001515 active site 1167634001516 catalytic residues [active] 1167634001517 heterodimer interface [polypeptide binding]; other site 1167634001518 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1167634001519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634001520 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1167634001521 catalytic residue [active] 1167634001522 acetylornithine deacetylase; Provisional; Region: PRK07522 1167634001523 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1167634001524 metal binding site [ion binding]; metal-binding site 1167634001525 putative dimer interface [polypeptide binding]; other site 1167634001526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634001527 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634001528 putative substrate translocation pore; other site 1167634001529 HD domain; Region: HD_4; pfam13328 1167634001530 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1167634001531 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1167634001532 synthetase active site [active] 1167634001533 NTP binding site [chemical binding]; other site 1167634001534 metal binding site [ion binding]; metal-binding site 1167634001535 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1167634001536 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1167634001537 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1167634001538 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1167634001539 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1167634001540 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1167634001541 homotrimer interaction site [polypeptide binding]; other site 1167634001542 putative active site [active] 1167634001543 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1167634001544 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1167634001545 active site 1167634001546 Ferredoxin [Energy production and conversion]; Region: COG1146 1167634001547 4Fe-4S binding domain; Region: Fer4; cl02805 1167634001548 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1167634001549 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1167634001550 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1167634001551 FAD binding pocket [chemical binding]; other site 1167634001552 FAD binding motif [chemical binding]; other site 1167634001553 phosphate binding motif [ion binding]; other site 1167634001554 beta-alpha-beta structure motif; other site 1167634001555 NAD binding pocket [chemical binding]; other site 1167634001556 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 1167634001557 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1167634001558 ferredoxin; Provisional; Region: PRK08764 1167634001559 Putative Fe-S cluster; Region: FeS; cl17515 1167634001560 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1167634001561 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1167634001562 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1167634001563 minor groove reading motif; other site 1167634001564 helix-hairpin-helix signature motif; other site 1167634001565 substrate binding pocket [chemical binding]; other site 1167634001566 active site 1167634001567 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1167634001568 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634001569 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634001570 Walker A/P-loop; other site 1167634001571 ATP binding site [chemical binding]; other site 1167634001572 Q-loop/lid; other site 1167634001573 ABC transporter signature motif; other site 1167634001574 Walker B; other site 1167634001575 D-loop; other site 1167634001576 H-loop/switch region; other site 1167634001577 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634001578 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634001579 Walker A/P-loop; other site 1167634001580 ATP binding site [chemical binding]; other site 1167634001581 Q-loop/lid; other site 1167634001582 ABC transporter signature motif; other site 1167634001583 Walker B; other site 1167634001584 D-loop; other site 1167634001585 H-loop/switch region; other site 1167634001586 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634001587 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1167634001588 putative ligand binding site [chemical binding]; other site 1167634001589 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634001590 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634001591 TM-ABC transporter signature motif; other site 1167634001592 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634001593 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634001594 TM-ABC transporter signature motif; other site 1167634001595 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1167634001596 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1167634001597 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1167634001598 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1167634001599 homodimer interface [polypeptide binding]; other site 1167634001600 substrate-cofactor binding pocket; other site 1167634001601 catalytic residue [active] 1167634001602 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1167634001603 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1167634001604 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1167634001605 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1167634001606 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1167634001607 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634001608 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634001609 Walker A/P-loop; other site 1167634001610 ATP binding site [chemical binding]; other site 1167634001611 Q-loop/lid; other site 1167634001612 ABC transporter signature motif; other site 1167634001613 Walker B; other site 1167634001614 D-loop; other site 1167634001615 H-loop/switch region; other site 1167634001616 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634001617 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634001618 TM-ABC transporter signature motif; other site 1167634001619 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634001620 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634001621 Walker A/P-loop; other site 1167634001622 ATP binding site [chemical binding]; other site 1167634001623 Q-loop/lid; other site 1167634001624 ABC transporter signature motif; other site 1167634001625 Walker B; other site 1167634001626 D-loop; other site 1167634001627 H-loop/switch region; other site 1167634001628 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1167634001629 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634001630 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634001631 TM-ABC transporter signature motif; other site 1167634001632 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1167634001633 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1167634001634 putative ligand binding site [chemical binding]; other site 1167634001635 BioY family; Region: BioY; pfam02632 1167634001636 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1167634001637 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1167634001638 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1167634001639 Walker A/P-loop; other site 1167634001640 ATP binding site [chemical binding]; other site 1167634001641 Q-loop/lid; other site 1167634001642 ABC transporter signature motif; other site 1167634001643 Walker B; other site 1167634001644 D-loop; other site 1167634001645 H-loop/switch region; other site 1167634001646 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1167634001647 SelR domain; Region: SelR; pfam01641 1167634001648 intracellular septation protein A; Reviewed; Region: PRK00259 1167634001649 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1167634001650 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1167634001651 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1167634001652 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1167634001653 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1167634001654 nucleotide binding pocket [chemical binding]; other site 1167634001655 K-X-D-G motif; other site 1167634001656 catalytic site [active] 1167634001657 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1167634001658 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1167634001659 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1167634001660 Dimer interface [polypeptide binding]; other site 1167634001661 BRCT sequence motif; other site 1167634001662 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1167634001663 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1167634001664 AAA domain; Region: AAA_23; pfam13476 1167634001665 Walker A/P-loop; other site 1167634001666 ATP binding site [chemical binding]; other site 1167634001667 Q-loop/lid; other site 1167634001668 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1167634001669 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1167634001670 ABC transporter signature motif; other site 1167634001671 Walker B; other site 1167634001672 D-loop; other site 1167634001673 H-loop/switch region; other site 1167634001674 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1167634001675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634001676 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1167634001677 Fe-S cluster binding site [ion binding]; other site 1167634001678 active site 1167634001679 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1167634001680 Glycoprotease family; Region: Peptidase_M22; pfam00814 1167634001681 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1167634001682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634001683 Coenzyme A binding pocket [chemical binding]; other site 1167634001684 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1167634001685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634001686 active site 1167634001687 phosphorylation site [posttranslational modification] 1167634001688 intermolecular recognition site; other site 1167634001689 dimerization interface [polypeptide binding]; other site 1167634001690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634001691 DNA binding site [nucleotide binding] 1167634001692 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634001693 dimerization interface [polypeptide binding]; other site 1167634001694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634001695 dimer interface [polypeptide binding]; other site 1167634001696 phosphorylation site [posttranslational modification] 1167634001697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634001698 ATP binding site [chemical binding]; other site 1167634001699 Mg2+ binding site [ion binding]; other site 1167634001700 G-X-G motif; other site 1167634001701 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1167634001702 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1167634001703 dimer interface [polypeptide binding]; other site 1167634001704 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1167634001705 catalytic triad [active] 1167634001706 peroxidatic and resolving cysteines [active] 1167634001707 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1167634001708 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1167634001709 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 1167634001710 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 1167634001711 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1167634001712 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1167634001713 homotrimer interaction site [polypeptide binding]; other site 1167634001714 zinc binding site [ion binding]; other site 1167634001715 CDP-binding sites; other site 1167634001716 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1167634001717 substrate binding site; other site 1167634001718 dimer interface; other site 1167634001719 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1167634001720 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1167634001721 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1167634001722 ATP binding site [chemical binding]; other site 1167634001723 putative Mg++ binding site [ion binding]; other site 1167634001724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634001725 nucleotide binding region [chemical binding]; other site 1167634001726 ATP-binding site [chemical binding]; other site 1167634001727 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1167634001728 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1167634001729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634001730 motif II; other site 1167634001731 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1167634001732 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634001733 N-terminal plug; other site 1167634001734 ligand-binding site [chemical binding]; other site 1167634001735 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 1167634001736 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1167634001737 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1167634001738 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1167634001739 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1167634001740 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1167634001741 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1167634001742 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1167634001743 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1167634001744 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1167634001745 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1167634001746 4Fe-4S binding domain; Region: Fer4; cl02805 1167634001747 4Fe-4S binding domain; Region: Fer4; cl02805 1167634001748 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1167634001749 NADH dehydrogenase subunit G; Validated; Region: PRK09129 1167634001750 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1167634001751 catalytic loop [active] 1167634001752 iron binding site [ion binding]; other site 1167634001753 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1167634001754 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 1167634001755 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1167634001756 SLBB domain; Region: SLBB; pfam10531 1167634001757 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1167634001758 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1167634001759 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1167634001760 putative dimer interface [polypeptide binding]; other site 1167634001761 [2Fe-2S] cluster binding site [ion binding]; other site 1167634001762 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1167634001763 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1167634001764 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1167634001765 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1167634001766 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1167634001767 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1167634001768 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1167634001769 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1167634001770 trimer interface [polypeptide binding]; other site 1167634001771 eyelet of channel; other site 1167634001772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634001773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634001774 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1167634001775 CoenzymeA binding site [chemical binding]; other site 1167634001776 subunit interaction site [polypeptide binding]; other site 1167634001777 PHB binding site; other site 1167634001778 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1167634001779 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1167634001780 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1167634001781 active site 1167634001782 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1167634001783 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1167634001784 active site 1167634001785 metal binding site [ion binding]; metal-binding site 1167634001786 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1167634001787 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1167634001788 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1167634001789 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1167634001790 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1167634001791 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 1167634001792 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634001793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634001794 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634001795 dimerization interface [polypeptide binding]; other site 1167634001796 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1167634001797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634001798 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1167634001799 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1167634001800 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1167634001801 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634001802 multidrug efflux protein; Reviewed; Region: PRK09577 1167634001803 Protein export membrane protein; Region: SecD_SecF; cl14618 1167634001804 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1167634001805 Predicted transcriptional regulator [Transcription]; Region: COG2345 1167634001806 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1167634001807 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1167634001808 multidrug efflux protein; Reviewed; Region: PRK09579 1167634001809 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1167634001810 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634001811 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634001812 BCCT family transporter; Region: BCCT; cl00569 1167634001813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634001814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634001815 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1167634001816 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1167634001817 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634001818 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1167634001819 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1167634001820 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1167634001821 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1167634001822 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1167634001823 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1167634001824 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1167634001825 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1167634001826 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634001827 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634001828 DNA-binding site [nucleotide binding]; DNA binding site 1167634001829 FCD domain; Region: FCD; pfam07729 1167634001830 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1167634001831 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634001832 Walker A/P-loop; other site 1167634001833 ATP binding site [chemical binding]; other site 1167634001834 Q-loop/lid; other site 1167634001835 ABC transporter signature motif; other site 1167634001836 Walker B; other site 1167634001837 D-loop; other site 1167634001838 H-loop/switch region; other site 1167634001839 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1167634001840 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634001841 Walker A/P-loop; other site 1167634001842 ATP binding site [chemical binding]; other site 1167634001843 Q-loop/lid; other site 1167634001844 ABC transporter signature motif; other site 1167634001845 Walker B; other site 1167634001846 D-loop; other site 1167634001847 H-loop/switch region; other site 1167634001848 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634001849 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1167634001850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634001851 dimer interface [polypeptide binding]; other site 1167634001852 conserved gate region; other site 1167634001853 putative PBP binding loops; other site 1167634001854 ABC-ATPase subunit interface; other site 1167634001855 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634001856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634001857 putative PBP binding loops; other site 1167634001858 dimer interface [polypeptide binding]; other site 1167634001859 ABC-ATPase subunit interface; other site 1167634001860 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1167634001861 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634001862 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1167634001863 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634001864 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1167634001865 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634001866 N-terminal plug; other site 1167634001867 ligand-binding site [chemical binding]; other site 1167634001868 beta-lactamase TEM; Provisional; Region: PRK15442 1167634001869 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1167634001870 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1167634001871 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634001872 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634001873 dimerization interface [polypeptide binding]; other site 1167634001874 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1167634001875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1167634001876 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1167634001877 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1167634001878 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1167634001879 Hemerythrin-like domain; Region: Hr-like; cd12108 1167634001880 Fe binding site [ion binding]; other site 1167634001881 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1167634001882 GAF domain; Region: GAF; pfam01590 1167634001883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634001884 Walker A motif; other site 1167634001885 ATP binding site [chemical binding]; other site 1167634001886 Walker B motif; other site 1167634001887 arginine finger; other site 1167634001888 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634001889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634001890 dimer interface [polypeptide binding]; other site 1167634001891 phosphorylation site [posttranslational modification] 1167634001892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634001893 ATP binding site [chemical binding]; other site 1167634001894 Mg2+ binding site [ion binding]; other site 1167634001895 G-X-G motif; other site 1167634001896 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1167634001897 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634001898 putative active site [active] 1167634001899 heme pocket [chemical binding]; other site 1167634001900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634001901 dimer interface [polypeptide binding]; other site 1167634001902 phosphorylation site [posttranslational modification] 1167634001903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634001904 ATP binding site [chemical binding]; other site 1167634001905 Mg2+ binding site [ion binding]; other site 1167634001906 G-X-G motif; other site 1167634001907 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634001908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634001909 active site 1167634001910 phosphorylation site [posttranslational modification] 1167634001911 intermolecular recognition site; other site 1167634001912 dimerization interface [polypeptide binding]; other site 1167634001913 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1167634001914 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1167634001915 active site 1167634001916 tetramer interface; other site 1167634001917 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634001918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634001919 active site 1167634001920 phosphorylation site [posttranslational modification] 1167634001921 intermolecular recognition site; other site 1167634001922 dimerization interface [polypeptide binding]; other site 1167634001923 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1167634001924 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1167634001925 active site 1167634001926 metal binding site [ion binding]; metal-binding site 1167634001927 short chain dehydrogenase; Provisional; Region: PRK07478 1167634001928 classical (c) SDRs; Region: SDR_c; cd05233 1167634001929 NAD(P) binding site [chemical binding]; other site 1167634001930 active site 1167634001931 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 1167634001932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634001933 NAD(P) binding site [chemical binding]; other site 1167634001934 active site 1167634001935 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1167634001936 Citrate transporter; Region: CitMHS; pfam03600 1167634001937 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1167634001938 catalytic triad [active] 1167634001939 putative active site [active] 1167634001940 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1167634001941 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 1167634001942 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1167634001943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634001944 active site 1167634001945 phosphorylation site [posttranslational modification] 1167634001946 intermolecular recognition site; other site 1167634001947 dimerization interface [polypeptide binding]; other site 1167634001948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634001949 DNA binding site [nucleotide binding] 1167634001950 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1167634001951 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1167634001952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634001953 dimer interface [polypeptide binding]; other site 1167634001954 phosphorylation site [posttranslational modification] 1167634001955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634001956 ATP binding site [chemical binding]; other site 1167634001957 Mg2+ binding site [ion binding]; other site 1167634001958 G-X-G motif; other site 1167634001959 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1167634001960 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1167634001961 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634001962 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634001963 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634001964 N-terminal plug; other site 1167634001965 ligand-binding site [chemical binding]; other site 1167634001966 fec operon regulator FecR; Reviewed; Region: PRK09774 1167634001967 FecR protein; Region: FecR; pfam04773 1167634001968 RNA polymerase sigma factor; Provisional; Region: PRK12528 1167634001969 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634001970 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634001971 DNA binding residues [nucleotide binding] 1167634001972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 1167634001973 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1167634001974 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634001975 N-terminal plug; other site 1167634001976 ligand-binding site [chemical binding]; other site 1167634001977 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634001978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634001979 Walker A/P-loop; other site 1167634001980 ATP binding site [chemical binding]; other site 1167634001981 Q-loop/lid; other site 1167634001982 ABC transporter signature motif; other site 1167634001983 Walker B; other site 1167634001984 D-loop; other site 1167634001985 H-loop/switch region; other site 1167634001986 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634001987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1167634001988 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1167634001989 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1167634001990 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1167634001991 ligand binding site [chemical binding]; other site 1167634001992 flexible hinge region; other site 1167634001993 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1167634001994 putative switch regulator; other site 1167634001995 non-specific DNA interactions [nucleotide binding]; other site 1167634001996 DNA binding site [nucleotide binding] 1167634001997 sequence specific DNA binding site [nucleotide binding]; other site 1167634001998 putative cAMP binding site [chemical binding]; other site 1167634001999 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1167634002000 apolar tunnel; other site 1167634002001 heme binding site [chemical binding]; other site 1167634002002 dimerization interface [polypeptide binding]; other site 1167634002003 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 1167634002004 META domain; Region: META; pfam03724 1167634002005 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 1167634002006 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1167634002007 AAA domain; Region: AAA_11; pfam13086 1167634002008 Part of AAA domain; Region: AAA_19; pfam13245 1167634002009 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1167634002010 AAA domain; Region: AAA_12; pfam13087 1167634002011 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1167634002012 putative active site [active] 1167634002013 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 1167634002014 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1167634002015 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1167634002016 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1167634002017 dimer interface [polypeptide binding]; other site 1167634002018 FMN binding site [chemical binding]; other site 1167634002019 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1167634002020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634002021 dimer interface [polypeptide binding]; other site 1167634002022 putative CheW interface [polypeptide binding]; other site 1167634002023 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1167634002024 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 1167634002025 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1167634002026 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1167634002027 ligand binding site [chemical binding]; other site 1167634002028 protein translocase, SecG subunit; Region: secG; TIGR00810 1167634002029 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1167634002030 triosephosphate isomerase; Provisional; Region: PRK14567 1167634002031 substrate binding site [chemical binding]; other site 1167634002032 dimer interface [polypeptide binding]; other site 1167634002033 catalytic triad [active] 1167634002034 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1167634002035 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1167634002036 NAD(P) binding site [chemical binding]; other site 1167634002037 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1167634002038 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634002039 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634002040 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634002041 dimerization interface [polypeptide binding]; other site 1167634002042 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1167634002043 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1167634002044 putative active site [active] 1167634002045 catalytic triad [active] 1167634002046 putative dimer interface [polypeptide binding]; other site 1167634002047 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1167634002048 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1167634002049 active site 1167634002050 DNA binding site [nucleotide binding] 1167634002051 Int/Topo IB signature motif; other site 1167634002052 tape measure domain; Region: tape_meas_nterm; TIGR02675 1167634002053 Phage major tail protein 2; Region: Phage_tail_2; cl11463 1167634002054 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1167634002055 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1167634002056 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1167634002057 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1167634002058 Phage terminase large subunit; Region: Terminase_3; cl12054 1167634002059 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1167634002060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1167634002061 Predicted transcriptional regulator [Transcription]; Region: COG2932 1167634002062 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1167634002063 Catalytic site [active] 1167634002064 AAA domain; Region: AAA_24; pfam13479 1167634002065 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1167634002066 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1167634002067 dimer interface [polypeptide binding]; other site 1167634002068 ssDNA binding site [nucleotide binding]; other site 1167634002069 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1167634002070 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1167634002071 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1167634002072 putative active site [active] 1167634002073 putative NTP binding site [chemical binding]; other site 1167634002074 putative nucleic acid binding site [nucleotide binding]; other site 1167634002075 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1167634002076 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 1167634002077 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 1167634002078 PIN domain; Region: PIN_3; pfam13470 1167634002079 threonine dehydratase; Provisional; Region: PRK07334 1167634002080 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1167634002081 tetramer interface [polypeptide binding]; other site 1167634002082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634002083 catalytic residue [active] 1167634002084 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1167634002085 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1167634002086 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1167634002087 RNase E interface [polypeptide binding]; other site 1167634002088 trimer interface [polypeptide binding]; other site 1167634002089 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1167634002090 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1167634002091 RNase E interface [polypeptide binding]; other site 1167634002092 trimer interface [polypeptide binding]; other site 1167634002093 active site 1167634002094 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1167634002095 putative nucleic acid binding region [nucleotide binding]; other site 1167634002096 G-X-X-G motif; other site 1167634002097 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1167634002098 RNA binding site [nucleotide binding]; other site 1167634002099 domain interface; other site 1167634002100 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1167634002101 16S/18S rRNA binding site [nucleotide binding]; other site 1167634002102 S13e-L30e interaction site [polypeptide binding]; other site 1167634002103 25S rRNA binding site [nucleotide binding]; other site 1167634002104 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1167634002105 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1167634002106 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1167634002107 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1167634002108 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1167634002109 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1167634002110 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1167634002111 putative valine binding site [chemical binding]; other site 1167634002112 dimer interface [polypeptide binding]; other site 1167634002113 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1167634002114 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 1167634002115 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1167634002116 PYR/PP interface [polypeptide binding]; other site 1167634002117 dimer interface [polypeptide binding]; other site 1167634002118 TPP binding site [chemical binding]; other site 1167634002119 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1167634002120 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1167634002121 TPP-binding site [chemical binding]; other site 1167634002122 dimer interface [polypeptide binding]; other site 1167634002123 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1167634002124 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1167634002125 hypothetical protein; Validated; Region: PRK02101 1167634002126 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1167634002127 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1167634002128 NAD binding site [chemical binding]; other site 1167634002129 homotetramer interface [polypeptide binding]; other site 1167634002130 homodimer interface [polypeptide binding]; other site 1167634002131 substrate binding site [chemical binding]; other site 1167634002132 active site 1167634002133 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1167634002134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634002135 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1167634002136 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634002137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634002138 Walker A/P-loop; other site 1167634002139 ATP binding site [chemical binding]; other site 1167634002140 Q-loop/lid; other site 1167634002141 ABC transporter signature motif; other site 1167634002142 Walker B; other site 1167634002143 D-loop; other site 1167634002144 H-loop/switch region; other site 1167634002145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634002146 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1167634002147 Walker A/P-loop; other site 1167634002148 ATP binding site [chemical binding]; other site 1167634002149 Q-loop/lid; other site 1167634002150 ABC transporter signature motif; other site 1167634002151 Walker B; other site 1167634002152 D-loop; other site 1167634002153 H-loop/switch region; other site 1167634002154 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1167634002155 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1167634002156 ABC-ATPase subunit interface; other site 1167634002157 dimer interface [polypeptide binding]; other site 1167634002158 putative PBP binding regions; other site 1167634002159 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1167634002160 ABC-ATPase subunit interface; other site 1167634002161 dimer interface [polypeptide binding]; other site 1167634002162 putative PBP binding regions; other site 1167634002163 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1167634002164 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1167634002165 Walker A/P-loop; other site 1167634002166 ATP binding site [chemical binding]; other site 1167634002167 Q-loop/lid; other site 1167634002168 ABC transporter signature motif; other site 1167634002169 Walker B; other site 1167634002170 D-loop; other site 1167634002171 H-loop/switch region; other site 1167634002172 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1167634002173 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1167634002174 putative ligand binding residues [chemical binding]; other site 1167634002175 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634002176 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634002177 N-terminal plug; other site 1167634002178 ligand-binding site [chemical binding]; other site 1167634002179 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634002180 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1167634002181 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1167634002182 inhibitor site; inhibition site 1167634002183 active site 1167634002184 dimer interface [polypeptide binding]; other site 1167634002185 catalytic residue [active] 1167634002186 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1167634002187 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1167634002188 active site pocket [active] 1167634002189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634002190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634002191 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 1167634002192 putative dimerization interface [polypeptide binding]; other site 1167634002193 cytosine deaminase; Provisional; Region: PRK05985 1167634002194 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1167634002195 active site 1167634002196 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1167634002197 seryl-tRNA synthetase; Provisional; Region: PRK05431 1167634002198 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1167634002199 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1167634002200 dimer interface [polypeptide binding]; other site 1167634002201 active site 1167634002202 motif 1; other site 1167634002203 motif 2; other site 1167634002204 motif 3; other site 1167634002205 recombination factor protein RarA; Reviewed; Region: PRK13342 1167634002206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634002207 Walker A motif; other site 1167634002208 ATP binding site [chemical binding]; other site 1167634002209 Walker B motif; other site 1167634002210 arginine finger; other site 1167634002211 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1167634002212 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1167634002213 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1167634002214 putative active site [active] 1167634002215 catalytic triad [active] 1167634002216 putative dimer interface [polypeptide binding]; other site 1167634002217 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1167634002218 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1167634002219 dimer interface [polypeptide binding]; other site 1167634002220 active site 1167634002221 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1167634002222 substrate binding site [chemical binding]; other site 1167634002223 catalytic residue [active] 1167634002224 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1167634002225 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1167634002226 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634002227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634002228 dimer interface [polypeptide binding]; other site 1167634002229 conserved gate region; other site 1167634002230 putative PBP binding loops; other site 1167634002231 ABC-ATPase subunit interface; other site 1167634002232 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1167634002233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634002234 dimer interface [polypeptide binding]; other site 1167634002235 conserved gate region; other site 1167634002236 putative PBP binding loops; other site 1167634002237 ABC-ATPase subunit interface; other site 1167634002238 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1167634002239 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634002240 Walker A/P-loop; other site 1167634002241 ATP binding site [chemical binding]; other site 1167634002242 Q-loop/lid; other site 1167634002243 ABC transporter signature motif; other site 1167634002244 Walker B; other site 1167634002245 D-loop; other site 1167634002246 H-loop/switch region; other site 1167634002247 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634002248 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1167634002249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634002250 Walker A/P-loop; other site 1167634002251 ATP binding site [chemical binding]; other site 1167634002252 Q-loop/lid; other site 1167634002253 ABC transporter signature motif; other site 1167634002254 Walker B; other site 1167634002255 D-loop; other site 1167634002256 H-loop/switch region; other site 1167634002257 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634002258 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1167634002259 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1167634002260 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1167634002261 putative active site [active] 1167634002262 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1167634002263 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1167634002264 active site 1167634002265 putative substrate binding pocket [chemical binding]; other site 1167634002266 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1167634002267 homotrimer interaction site [polypeptide binding]; other site 1167634002268 putative active site [active] 1167634002269 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1167634002270 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1167634002271 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1167634002272 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1167634002273 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1167634002274 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1167634002275 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1167634002276 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634002277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1167634002278 Smr domain; Region: Smr; pfam01713 1167634002279 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1167634002280 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1167634002281 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 1167634002282 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 1167634002283 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1167634002284 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1167634002285 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1167634002286 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1167634002287 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1167634002288 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1167634002289 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1167634002290 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1167634002291 Ligand Binding Site [chemical binding]; other site 1167634002292 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1167634002293 GAF domain; Region: GAF_3; pfam13492 1167634002294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634002295 dimer interface [polypeptide binding]; other site 1167634002296 phosphorylation site [posttranslational modification] 1167634002297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634002298 ATP binding site [chemical binding]; other site 1167634002299 Mg2+ binding site [ion binding]; other site 1167634002300 G-X-G motif; other site 1167634002301 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1167634002302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634002303 active site 1167634002304 phosphorylation site [posttranslational modification] 1167634002305 intermolecular recognition site; other site 1167634002306 dimerization interface [polypeptide binding]; other site 1167634002307 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634002308 DNA binding site [nucleotide binding] 1167634002309 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694 1167634002310 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1167634002311 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1167634002312 dimer interface [polypeptide binding]; other site 1167634002313 active site 1167634002314 catalytic residue [active] 1167634002315 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1167634002316 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634002317 dimerization interface [polypeptide binding]; other site 1167634002318 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1167634002319 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634002320 dimer interface [polypeptide binding]; other site 1167634002321 putative CheW interface [polypeptide binding]; other site 1167634002322 O-Antigen ligase; Region: Wzy_C; pfam04932 1167634002323 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1167634002324 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1167634002325 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1167634002326 isocitrate dehydrogenase; Validated; Region: PRK07362 1167634002327 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1167634002328 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1167634002329 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1167634002330 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1167634002331 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1167634002332 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1167634002333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634002334 Walker A motif; other site 1167634002335 ATP binding site [chemical binding]; other site 1167634002336 Walker B motif; other site 1167634002337 arginine finger; other site 1167634002338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1167634002339 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1167634002340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634002341 Coenzyme A binding pocket [chemical binding]; other site 1167634002342 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1167634002343 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1167634002344 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1167634002345 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1167634002346 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1167634002347 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1167634002348 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1167634002349 chaperone protein DnaJ; Provisional; Region: PRK10767 1167634002350 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1167634002351 HSP70 interaction site [polypeptide binding]; other site 1167634002352 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1167634002353 Zn binding sites [ion binding]; other site 1167634002354 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1167634002355 dimer interface [polypeptide binding]; other site 1167634002356 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1167634002357 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1167634002358 nucleotide binding site [chemical binding]; other site 1167634002359 NEF interaction site [polypeptide binding]; other site 1167634002360 SBD interface [polypeptide binding]; other site 1167634002361 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1167634002362 catalytic residues [active] 1167634002363 GrpE; Region: GrpE; pfam01025 1167634002364 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1167634002365 dimer interface [polypeptide binding]; other site 1167634002366 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1167634002367 ferrochelatase; Reviewed; Region: hemH; PRK00035 1167634002368 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1167634002369 C-terminal domain interface [polypeptide binding]; other site 1167634002370 active site 1167634002371 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1167634002372 active site 1167634002373 N-terminal domain interface [polypeptide binding]; other site 1167634002374 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1167634002375 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1167634002376 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 1167634002377 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1167634002378 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1167634002379 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1167634002380 Walker A/P-loop; other site 1167634002381 ATP binding site [chemical binding]; other site 1167634002382 Q-loop/lid; other site 1167634002383 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1167634002384 ABC transporter signature motif; other site 1167634002385 Walker B; other site 1167634002386 D-loop; other site 1167634002387 H-loop/switch region; other site 1167634002388 ferric uptake regulator; Provisional; Region: fur; PRK09462 1167634002389 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1167634002390 metal binding site 2 [ion binding]; metal-binding site 1167634002391 putative DNA binding helix; other site 1167634002392 metal binding site 1 [ion binding]; metal-binding site 1167634002393 dimer interface [polypeptide binding]; other site 1167634002394 structural Zn2+ binding site [ion binding]; other site 1167634002395 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1167634002396 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1167634002397 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1167634002398 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1167634002399 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1167634002400 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1167634002401 FAD binding domain; Region: FAD_binding_4; pfam01565 1167634002402 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1167634002403 integrase; Provisional; Region: PRK09692 1167634002404 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1167634002405 active site 1167634002406 Int/Topo IB signature motif; other site 1167634002407 transcriptional regulator; Provisional; Region: PRK10632 1167634002408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634002409 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634002410 putative effector binding pocket; other site 1167634002411 dimerization interface [polypeptide binding]; other site 1167634002412 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1167634002413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634002414 putative substrate translocation pore; other site 1167634002415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634002416 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1167634002417 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634002418 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634002419 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1167634002420 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1167634002421 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1167634002422 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1167634002423 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1167634002424 D-pathway; other site 1167634002425 Putative ubiquinol binding site [chemical binding]; other site 1167634002426 Low-spin heme (heme b) binding site [chemical binding]; other site 1167634002427 Putative water exit pathway; other site 1167634002428 Binuclear center (heme o3/CuB) [ion binding]; other site 1167634002429 K-pathway; other site 1167634002430 Putative proton exit pathway; other site 1167634002431 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1167634002432 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1167634002433 HAMP domain; Region: HAMP; pfam00672 1167634002434 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634002435 dimer interface [polypeptide binding]; other site 1167634002436 putative CheW interface [polypeptide binding]; other site 1167634002437 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1167634002438 Putative helicase; Region: TraI_2; pfam07514 1167634002439 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1167634002440 RES domain; Region: RES; smart00953 1167634002441 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1167634002442 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1167634002443 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1167634002444 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 1167634002445 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1167634002446 catalytic residues [active] 1167634002447 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1167634002448 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1167634002449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1167634002450 Walker A motif; other site 1167634002451 ATP binding site [chemical binding]; other site 1167634002452 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1167634002453 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1167634002454 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 1167634002455 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 1167634002456 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1167634002457 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 1167634002458 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 1167634002459 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 1167634002460 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1167634002461 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1167634002462 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 1167634002463 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1167634002464 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 1167634002465 integrating conjugative element protein, PFL_4695 family; Region: ICE_PFL_4695; TIGR03765 1167634002466 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1167634002467 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1167634002468 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1167634002469 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1167634002470 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1167634002471 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634002472 nucleotide binding region [chemical binding]; other site 1167634002473 ATP-binding site [chemical binding]; other site 1167634002474 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1167634002475 S-adenosylmethionine binding site [chemical binding]; other site 1167634002476 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 1167634002477 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1167634002478 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1167634002479 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 1167634002480 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1167634002481 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1167634002482 DNA topoisomerase III; Provisional; Region: PRK07726 1167634002483 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1167634002484 active site 1167634002485 putative interdomain interaction site [polypeptide binding]; other site 1167634002486 putative metal-binding site [ion binding]; other site 1167634002487 putative nucleotide binding site [chemical binding]; other site 1167634002488 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1167634002489 domain I; other site 1167634002490 DNA binding groove [nucleotide binding] 1167634002491 phosphate binding site [ion binding]; other site 1167634002492 domain II; other site 1167634002493 domain III; other site 1167634002494 nucleotide binding site [chemical binding]; other site 1167634002495 catalytic site [active] 1167634002496 domain IV; other site 1167634002497 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1167634002498 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1167634002499 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1167634002500 ssDNA binding site [nucleotide binding]; other site 1167634002501 dimer interface [polypeptide binding]; other site 1167634002502 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1167634002503 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 1167634002504 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 1167634002505 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1167634002506 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1167634002507 ParB-like nuclease domain; Region: ParBc; pfam02195 1167634002508 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1167634002509 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1167634002510 Magnesium ion binding site [ion binding]; other site 1167634002511 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1167634002512 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1167634002513 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1167634002514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634002515 Coenzyme A binding pocket [chemical binding]; other site 1167634002516 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634002517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634002518 DNA-binding site [nucleotide binding]; DNA binding site 1167634002519 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634002520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634002521 homodimer interface [polypeptide binding]; other site 1167634002522 catalytic residue [active] 1167634002523 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1167634002524 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1167634002525 integrase; Provisional; Region: PRK09692 1167634002526 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1167634002527 active site 1167634002528 Int/Topo IB signature motif; other site 1167634002529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1167634002530 Helix-turn-helix domain; Region: HTH_38; pfam13936 1167634002531 Helix-turn-helix domain; Region: HTH_17; pfam12728 1167634002532 Integrase core domain; Region: rve; pfam00665 1167634002533 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1167634002534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634002535 Walker A motif; other site 1167634002536 ATP binding site [chemical binding]; other site 1167634002537 Walker B motif; other site 1167634002538 arginine finger; other site 1167634002539 Outer membrane efflux protein; Region: OEP; pfam02321 1167634002540 Outer membrane efflux protein; Region: OEP; pfam02321 1167634002541 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1167634002542 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1167634002543 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1167634002544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1167634002545 HTH-like domain; Region: HTH_21; pfam13276 1167634002546 Integrase core domain; Region: rve; pfam00665 1167634002547 Integrase core domain; Region: rve_3; pfam13683 1167634002548 Transposase; Region: HTH_Tnp_1; pfam01527 1167634002549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634002550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634002551 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1167634002552 dimerization interface [polypeptide binding]; other site 1167634002553 substrate binding pocket [chemical binding]; other site 1167634002554 Copper resistance protein K; Region: CopK; pfam11525 1167634002555 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1167634002556 CopC domain; Region: CopC; pfam04234 1167634002557 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1167634002558 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1167634002559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634002560 motif II; other site 1167634002561 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 1167634002562 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1167634002563 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1167634002564 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1167634002565 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1167634002566 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1167634002567 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1167634002568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634002569 active site 1167634002570 phosphorylation site [posttranslational modification] 1167634002571 intermolecular recognition site; other site 1167634002572 dimerization interface [polypeptide binding]; other site 1167634002573 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634002574 DNA binding site [nucleotide binding] 1167634002575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634002576 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634002577 dimerization interface [polypeptide binding]; other site 1167634002578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634002579 dimer interface [polypeptide binding]; other site 1167634002580 phosphorylation site [posttranslational modification] 1167634002581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634002582 ATP binding site [chemical binding]; other site 1167634002583 Mg2+ binding site [ion binding]; other site 1167634002584 G-X-G motif; other site 1167634002585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634002586 putative DNA binding site [nucleotide binding]; other site 1167634002587 putative Zn2+ binding site [ion binding]; other site 1167634002588 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1167634002589 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634002590 putative metal binding site [ion binding]; other site 1167634002591 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1167634002592 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1167634002593 active site 1167634002594 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1167634002595 arsenical-resistance protein; Region: acr3; TIGR00832 1167634002596 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1167634002597 ArsC family; Region: ArsC; pfam03960 1167634002598 catalytic residues [active] 1167634002599 Predicted transcriptional regulators [Transcription]; Region: COG1695 1167634002600 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1167634002601 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1167634002602 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1167634002603 Chromate transporter; Region: Chromate_transp; pfam02417 1167634002604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634002605 Coenzyme A binding pocket [chemical binding]; other site 1167634002606 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1167634002607 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634002608 HlyD family secretion protein; Region: HlyD; pfam00529 1167634002609 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634002610 Putative helicase; Region: TraI_2; pfam07514 1167634002611 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1167634002612 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1167634002613 RES domain; Region: RES; smart00953 1167634002614 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1167634002615 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1167634002616 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1167634002617 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 1167634002618 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1167634002619 MPN+ (JAMM) motif; other site 1167634002620 Zinc-binding site [ion binding]; other site 1167634002621 Thioredoxin; Region: Thioredoxin_4; cl17273 1167634002622 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1167634002623 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1167634002624 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1167634002625 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1167634002626 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 1167634002627 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1167634002628 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 1167634002629 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 1167634002630 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 1167634002631 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1167634002632 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1167634002633 DNA binding domain, excisionase family; Region: excise; TIGR01764 1167634002634 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 1167634002635 HORMA domain; Region: HORMA; pfam02301 1167634002636 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 1167634002637 active site 1167634002638 NTP binding site [chemical binding]; other site 1167634002639 metal binding triad [ion binding]; metal-binding site 1167634002640 AAA domain; Region: AAA_23; pfam13476 1167634002641 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1167634002642 AAA domain; Region: AAA_21; pfam13304 1167634002643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634002644 ABC transporter signature motif; other site 1167634002645 Walker B; other site 1167634002646 D-loop; other site 1167634002647 H-loop/switch region; other site 1167634002648 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 1167634002649 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1167634002650 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 1167634002651 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 1167634002652 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1167634002653 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1167634002654 catalytic residue [active] 1167634002655 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1167634002656 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1167634002657 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1167634002658 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634002659 nucleotide binding region [chemical binding]; other site 1167634002660 ATP-binding site [chemical binding]; other site 1167634002661 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1167634002662 S-adenosylmethionine binding site [chemical binding]; other site 1167634002663 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 1167634002664 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1167634002665 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1167634002666 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1167634002667 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 1167634002668 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1167634002669 putative mercuric reductase; Provisional; Region: PRK13748 1167634002670 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1167634002671 metal-binding site [ion binding] 1167634002672 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1167634002673 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634002674 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1167634002675 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1167634002676 metal-binding site [ion binding] 1167634002677 putative mercuric transport protein; Provisional; Region: PRK13751 1167634002678 putative transcriptional regulator MerR; Provisional; Region: PRK13752 1167634002679 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 1167634002680 DNA binding residues [nucleotide binding] 1167634002681 dimer interface [polypeptide binding]; other site 1167634002682 mercury binding site [ion binding]; other site 1167634002683 Herpesvirus UL36 tegument protein; Region: Herpes_UL36; pfam03586 1167634002684 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1167634002685 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1167634002686 metal-binding site [ion binding] 1167634002687 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1167634002688 metal-binding site [ion binding] 1167634002689 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1167634002690 metal-binding site [ion binding] 1167634002691 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1167634002692 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1167634002693 metal-binding site [ion binding] 1167634002694 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1167634002695 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1167634002696 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1167634002697 DNA binding residues [nucleotide binding] 1167634002698 dimer interface [polypeptide binding]; other site 1167634002699 putative metal binding site [ion binding]; other site 1167634002700 Cation efflux family; Region: Cation_efflux; cl00316 1167634002701 DNA topoisomerase III; Provisional; Region: PRK07726 1167634002702 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1167634002703 active site 1167634002704 putative interdomain interaction site [polypeptide binding]; other site 1167634002705 putative metal-binding site [ion binding]; other site 1167634002706 putative nucleotide binding site [chemical binding]; other site 1167634002707 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1167634002708 domain I; other site 1167634002709 DNA binding groove [nucleotide binding] 1167634002710 phosphate binding site [ion binding]; other site 1167634002711 domain II; other site 1167634002712 domain III; other site 1167634002713 nucleotide binding site [chemical binding]; other site 1167634002714 catalytic site [active] 1167634002715 domain IV; other site 1167634002716 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1167634002717 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1167634002718 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1167634002719 dimer interface [polypeptide binding]; other site 1167634002720 ssDNA binding site [nucleotide binding]; other site 1167634002721 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1167634002722 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 1167634002723 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 1167634002724 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1167634002725 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1167634002726 ParB-like nuclease domain; Region: ParBc; pfam02195 1167634002727 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1167634002728 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1167634002729 Magnesium ion binding site [ion binding]; other site 1167634002730 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1167634002731 integrase; Provisional; Region: PRK09692 1167634002732 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1167634002733 active site 1167634002734 Int/Topo IB signature motif; other site 1167634002735 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1167634002736 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634002737 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1167634002738 dimerization interface [polypeptide binding]; other site 1167634002739 substrate binding pocket [chemical binding]; other site 1167634002740 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1167634002741 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1167634002742 NAD binding site [chemical binding]; other site 1167634002743 catalytic Zn binding site [ion binding]; other site 1167634002744 structural Zn binding site [ion binding]; other site 1167634002745 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1167634002746 excinuclease ABC subunit B; Provisional; Region: PRK05298 1167634002747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1167634002748 ATP binding site [chemical binding]; other site 1167634002749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634002750 nucleotide binding region [chemical binding]; other site 1167634002751 ATP-binding site [chemical binding]; other site 1167634002752 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1167634002753 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634002754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634002755 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634002756 putative effector binding pocket; other site 1167634002757 dimerization interface [polypeptide binding]; other site 1167634002758 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1167634002759 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1167634002760 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1167634002761 putative active site [active] 1167634002762 catalytic triad [active] 1167634002763 putative dimer interface [polypeptide binding]; other site 1167634002764 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1167634002765 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1167634002766 substrate binding site [chemical binding]; other site 1167634002767 catalytic Zn binding site [ion binding]; other site 1167634002768 NAD binding site [chemical binding]; other site 1167634002769 structural Zn binding site [ion binding]; other site 1167634002770 dimer interface [polypeptide binding]; other site 1167634002771 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634002772 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1167634002773 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 1167634002774 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1167634002775 S-formylglutathione hydrolase; Region: PLN02442 1167634002776 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1167634002777 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634002778 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634002779 recombination factor protein RarA; Reviewed; Region: PRK13342 1167634002780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634002781 Walker A motif; other site 1167634002782 ATP binding site [chemical binding]; other site 1167634002783 Walker B motif; other site 1167634002784 arginine finger; other site 1167634002785 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1167634002786 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1167634002787 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1167634002788 Thioredoxin; Region: Thioredoxin_4; pfam13462 1167634002789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634002790 Walker A/P-loop; other site 1167634002791 ATP binding site [chemical binding]; other site 1167634002792 Q-loop/lid; other site 1167634002793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634002794 ABC transporter signature motif; other site 1167634002795 Walker B; other site 1167634002796 D-loop; other site 1167634002797 H-loop/switch region; other site 1167634002798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634002799 AAA domain; Region: AAA_21; pfam13304 1167634002800 Walker A/P-loop; other site 1167634002801 ATP binding site [chemical binding]; other site 1167634002802 Q-loop/lid; other site 1167634002803 ABC transporter signature motif; other site 1167634002804 Walker B; other site 1167634002805 D-loop; other site 1167634002806 H-loop/switch region; other site 1167634002807 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1167634002808 Putative helicase; Region: TraI_2; pfam07514 1167634002809 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1167634002810 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1167634002811 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1167634002812 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 1167634002813 Protein of unknown function (DUF3742); Region: DUF3742; pfam12553 1167634002814 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1167634002815 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1167634002816 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1167634002817 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 1167634002818 RadC-like JAB domain; Region: RadC; pfam04002 1167634002819 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1167634002820 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1167634002821 catalytic residues [active] 1167634002822 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1167634002823 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1167634002824 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1167634002825 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1167634002826 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 1167634002827 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1167634002828 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 1167634002829 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 1167634002830 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 1167634002831 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1167634002832 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1167634002833 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 1167634002834 AAA domain; Region: AAA_23; pfam13476 1167634002835 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1167634002836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634002837 ABC transporter signature motif; other site 1167634002838 Walker B; other site 1167634002839 D-loop; other site 1167634002840 H-loop/switch region; other site 1167634002841 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 1167634002842 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1167634002843 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 1167634002844 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 1167634002845 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1167634002846 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1167634002847 catalytic residue [active] 1167634002848 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1167634002849 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1167634002850 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1167634002851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634002852 Walker A/P-loop; other site 1167634002853 ATP binding site [chemical binding]; other site 1167634002854 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1167634002855 putative active site [active] 1167634002856 putative metal-binding site [ion binding]; other site 1167634002857 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1167634002858 Part of AAA domain; Region: AAA_19; pfam13245 1167634002859 Family description; Region: UvrD_C_2; pfam13538 1167634002860 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1167634002861 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634002862 nucleotide binding region [chemical binding]; other site 1167634002863 ATP-binding site [chemical binding]; other site 1167634002864 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1167634002865 S-adenosylmethionine binding site [chemical binding]; other site 1167634002866 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 1167634002867 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1167634002868 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1167634002869 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1167634002870 DNA topoisomerase III; Provisional; Region: PRK07726 1167634002871 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1167634002872 active site 1167634002873 putative interdomain interaction site [polypeptide binding]; other site 1167634002874 putative metal-binding site [ion binding]; other site 1167634002875 putative nucleotide binding site [chemical binding]; other site 1167634002876 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1167634002877 domain I; other site 1167634002878 DNA binding groove [nucleotide binding] 1167634002879 phosphate binding site [ion binding]; other site 1167634002880 domain II; other site 1167634002881 domain III; other site 1167634002882 nucleotide binding site [chemical binding]; other site 1167634002883 catalytic site [active] 1167634002884 domain IV; other site 1167634002885 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1167634002886 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1167634002887 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1167634002888 ssDNA binding site [nucleotide binding]; other site 1167634002889 dimer interface [polypeptide binding]; other site 1167634002890 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1167634002891 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 1167634002892 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 1167634002893 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1167634002894 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1167634002895 ParB-like nuclease domain; Region: ParBc; pfam02195 1167634002896 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1167634002897 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1167634002898 Magnesium ion binding site [ion binding]; other site 1167634002899 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1167634002900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634002901 dimerization interface [polypeptide binding]; other site 1167634002902 putative DNA binding site [nucleotide binding]; other site 1167634002903 putative Zn2+ binding site [ion binding]; other site 1167634002904 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1167634002905 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1167634002906 active site 1167634002907 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1167634002908 arsenical-resistance protein; Region: acr3; TIGR00832 1167634002909 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634002910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634002911 putative substrate translocation pore; other site 1167634002912 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1167634002913 ArsC family; Region: ArsC; pfam03960 1167634002914 catalytic residues [active] 1167634002915 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 1167634002916 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1167634002917 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 1167634002918 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1167634002919 Predicted membrane protein [Function unknown]; Region: COG2259 1167634002920 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634002921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634002922 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634002923 putative effector binding pocket; other site 1167634002924 dimerization interface [polypeptide binding]; other site 1167634002925 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1167634002926 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1167634002927 nudix motif; other site 1167634002928 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1167634002929 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1167634002930 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1167634002931 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1167634002932 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1167634002933 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1167634002934 quinone interaction residues [chemical binding]; other site 1167634002935 active site 1167634002936 catalytic residues [active] 1167634002937 FMN binding site [chemical binding]; other site 1167634002938 substrate binding site [chemical binding]; other site 1167634002939 Phasin protein; Region: Phasin_2; pfam09361 1167634002940 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634002941 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1167634002942 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634002943 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634002944 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1167634002945 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 1167634002946 MPT binding site; other site 1167634002947 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 1167634002948 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1167634002949 catalytic residues [active] 1167634002950 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1167634002951 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1167634002952 ATP binding site [chemical binding]; other site 1167634002953 Mg++ binding site [ion binding]; other site 1167634002954 motif III; other site 1167634002955 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634002956 nucleotide binding region [chemical binding]; other site 1167634002957 ATP-binding site [chemical binding]; other site 1167634002958 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634002959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634002960 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634002961 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634002962 N-terminal plug; other site 1167634002963 ligand-binding site [chemical binding]; other site 1167634002964 muropeptide transporter; Validated; Region: ampG; cl17669 1167634002965 hypothetical protein; Provisional; Region: PRK07588 1167634002966 hypothetical protein; Provisional; Region: PRK07236 1167634002967 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634002968 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1167634002969 AzlC protein; Region: AzlC; pfam03591 1167634002970 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1167634002971 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1167634002972 homodimer interface [polypeptide binding]; other site 1167634002973 substrate-cofactor binding pocket; other site 1167634002974 catalytic residue [active] 1167634002975 Zinc-finger domain; Region: zf-CHCC; cl01821 1167634002976 SnoaL-like domain; Region: SnoaL_3; pfam13474 1167634002977 SnoaL-like domain; Region: SnoaL_2; pfam12680 1167634002978 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1167634002979 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1167634002980 Peptidase family M48; Region: Peptidase_M48; pfam01435 1167634002981 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1167634002982 active site 1167634002983 tetramer interface; other site 1167634002984 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1167634002985 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1167634002986 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1167634002987 eyelet of channel; other site 1167634002988 trimer interface [polypeptide binding]; other site 1167634002989 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1167634002990 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1167634002991 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1167634002992 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1167634002993 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1167634002994 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1167634002995 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1167634002996 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1167634002997 proline aminopeptidase P II; Provisional; Region: PRK10879 1167634002998 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1167634002999 active site 1167634003000 hypothetical protein; Provisional; Region: PRK06996 1167634003001 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634003002 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1167634003003 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1167634003004 FMN binding site [chemical binding]; other site 1167634003005 active site 1167634003006 catalytic residues [active] 1167634003007 substrate binding site [chemical binding]; other site 1167634003008 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1167634003009 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1167634003010 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1167634003011 purine monophosphate binding site [chemical binding]; other site 1167634003012 dimer interface [polypeptide binding]; other site 1167634003013 putative catalytic residues [active] 1167634003014 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1167634003015 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1167634003016 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1167634003017 active site 1167634003018 putative DNA-binding cleft [nucleotide binding]; other site 1167634003019 dimer interface [polypeptide binding]; other site 1167634003020 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1167634003021 RuvA N terminal domain; Region: RuvA_N; pfam01330 1167634003022 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1167634003023 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1167634003024 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1167634003025 putative NAD(P) binding site [chemical binding]; other site 1167634003026 active site 1167634003027 serine racemase; Region: PLN02970 1167634003028 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1167634003029 tetramer interface [polypeptide binding]; other site 1167634003030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634003031 catalytic residue [active] 1167634003032 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1167634003033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634003034 Walker A motif; other site 1167634003035 ATP binding site [chemical binding]; other site 1167634003036 Walker B motif; other site 1167634003037 arginine finger; other site 1167634003038 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1167634003039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634003040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634003041 ATP binding site [chemical binding]; other site 1167634003042 Mg2+ binding site [ion binding]; other site 1167634003043 G-X-G motif; other site 1167634003044 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1167634003045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634003046 active site 1167634003047 phosphorylation site [posttranslational modification] 1167634003048 intermolecular recognition site; other site 1167634003049 dimerization interface [polypeptide binding]; other site 1167634003050 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634003051 DNA binding site [nucleotide binding] 1167634003052 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1167634003053 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1167634003054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1167634003055 ATP binding site [chemical binding]; other site 1167634003056 putative Mg++ binding site [ion binding]; other site 1167634003057 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634003058 nucleotide binding region [chemical binding]; other site 1167634003059 ATP-binding site [chemical binding]; other site 1167634003060 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1167634003061 HRDC domain; Region: HRDC; pfam00570 1167634003062 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1167634003063 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1167634003064 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1167634003065 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1167634003066 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1167634003067 active site 1167634003068 HIGH motif; other site 1167634003069 nucleotide binding site [chemical binding]; other site 1167634003070 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1167634003071 KMSKS motif; other site 1167634003072 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1167634003073 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1167634003074 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1167634003075 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1167634003076 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1167634003077 Switch I; other site 1167634003078 Switch II; other site 1167634003079 cell division topological specificity factor MinE; Provisional; Region: PRK13989 1167634003080 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1167634003081 Isochorismatase family; Region: Isochorismatase; pfam00857 1167634003082 catalytic triad [active] 1167634003083 conserved cis-peptide bond; other site 1167634003084 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1167634003085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634003086 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634003087 ABC transporter; Region: ABC_tran_2; pfam12848 1167634003088 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634003089 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1167634003090 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634003091 EamA-like transporter family; Region: EamA; pfam00892 1167634003092 EamA-like transporter family; Region: EamA; pfam00892 1167634003093 Cupin domain; Region: Cupin_2; cl17218 1167634003094 Helix-turn-helix domain; Region: HTH_18; pfam12833 1167634003095 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1167634003096 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634003097 Walker A/P-loop; other site 1167634003098 ATP binding site [chemical binding]; other site 1167634003099 Q-loop/lid; other site 1167634003100 ABC transporter signature motif; other site 1167634003101 Walker B; other site 1167634003102 D-loop; other site 1167634003103 H-loop/switch region; other site 1167634003104 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634003105 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1167634003106 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634003107 Walker A/P-loop; other site 1167634003108 ATP binding site [chemical binding]; other site 1167634003109 Q-loop/lid; other site 1167634003110 ABC transporter signature motif; other site 1167634003111 Walker B; other site 1167634003112 D-loop; other site 1167634003113 H-loop/switch region; other site 1167634003114 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634003115 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1167634003116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634003117 dimer interface [polypeptide binding]; other site 1167634003118 conserved gate region; other site 1167634003119 putative PBP binding loops; other site 1167634003120 ABC-ATPase subunit interface; other site 1167634003121 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634003122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634003123 dimer interface [polypeptide binding]; other site 1167634003124 conserved gate region; other site 1167634003125 putative PBP binding loops; other site 1167634003126 ABC-ATPase subunit interface; other site 1167634003127 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1167634003128 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1167634003129 MarR family; Region: MarR_2; cl17246 1167634003130 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1167634003131 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 1167634003132 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1167634003133 dimer interface [polypeptide binding]; other site 1167634003134 PYR/PP interface [polypeptide binding]; other site 1167634003135 TPP binding site [chemical binding]; other site 1167634003136 substrate binding site [chemical binding]; other site 1167634003137 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 1167634003138 TPP-binding site; other site 1167634003139 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 1167634003140 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1167634003141 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1167634003142 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1167634003143 FMN-binding pocket [chemical binding]; other site 1167634003144 flavin binding motif; other site 1167634003145 phosphate binding motif [ion binding]; other site 1167634003146 beta-alpha-beta structure motif; other site 1167634003147 NAD binding pocket [chemical binding]; other site 1167634003148 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1167634003149 catalytic loop [active] 1167634003150 iron binding site [ion binding]; other site 1167634003151 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1167634003152 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 1167634003153 iron-sulfur cluster [ion binding]; other site 1167634003154 [2Fe-2S] cluster binding site [ion binding]; other site 1167634003155 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1167634003156 putative alpha subunit interface [polypeptide binding]; other site 1167634003157 putative active site [active] 1167634003158 putative substrate binding site [chemical binding]; other site 1167634003159 Fe binding site [ion binding]; other site 1167634003160 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1167634003161 inter-subunit interface; other site 1167634003162 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1167634003163 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1167634003164 acyl-activating enzyme (AAE) consensus motif; other site 1167634003165 putative AMP binding site [chemical binding]; other site 1167634003166 putative active site [active] 1167634003167 putative CoA binding site [chemical binding]; other site 1167634003168 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1167634003169 active site 1167634003170 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1167634003171 DUF35 OB-fold domain; Region: DUF35; pfam01796 1167634003172 short chain dehydrogenase; Validated; Region: PRK08264 1167634003173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634003174 NAD(P) binding site [chemical binding]; other site 1167634003175 active site 1167634003176 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1167634003177 short chain dehydrogenase; Provisional; Region: PRK07577 1167634003178 classical (c) SDRs; Region: SDR_c; cd05233 1167634003179 NAD(P) binding site [chemical binding]; other site 1167634003180 active site 1167634003181 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1167634003182 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1167634003183 putative ligand binding site [chemical binding]; other site 1167634003184 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634003185 TM-ABC transporter signature motif; other site 1167634003186 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634003187 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634003188 TM-ABC transporter signature motif; other site 1167634003189 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634003190 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634003191 Walker A/P-loop; other site 1167634003192 ATP binding site [chemical binding]; other site 1167634003193 Q-loop/lid; other site 1167634003194 ABC transporter signature motif; other site 1167634003195 Walker B; other site 1167634003196 D-loop; other site 1167634003197 H-loop/switch region; other site 1167634003198 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634003199 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634003200 Walker A/P-loop; other site 1167634003201 ATP binding site [chemical binding]; other site 1167634003202 Q-loop/lid; other site 1167634003203 ABC transporter signature motif; other site 1167634003204 Walker B; other site 1167634003205 D-loop; other site 1167634003206 H-loop/switch region; other site 1167634003207 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1167634003208 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1167634003209 active site 1167634003210 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634003211 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003212 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634003213 putative effector binding pocket; other site 1167634003214 dimerization interface [polypeptide binding]; other site 1167634003215 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1167634003216 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1167634003217 substrate binding site [chemical binding]; other site 1167634003218 ATP binding site [chemical binding]; other site 1167634003219 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1167634003220 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1167634003221 active site 1167634003222 intersubunit interface [polypeptide binding]; other site 1167634003223 catalytic residue [active] 1167634003224 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634003225 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1167634003226 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634003227 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1167634003228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634003229 Walker A/P-loop; other site 1167634003230 ATP binding site [chemical binding]; other site 1167634003231 Q-loop/lid; other site 1167634003232 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1167634003233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634003234 Walker A/P-loop; other site 1167634003235 ATP binding site [chemical binding]; other site 1167634003236 Q-loop/lid; other site 1167634003237 ABC transporter signature motif; other site 1167634003238 Walker B; other site 1167634003239 D-loop; other site 1167634003240 H-loop/switch region; other site 1167634003241 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1167634003242 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1167634003243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634003244 Walker A/P-loop; other site 1167634003245 ATP binding site [chemical binding]; other site 1167634003246 Q-loop/lid; other site 1167634003247 ABC transporter signature motif; other site 1167634003248 Walker B; other site 1167634003249 D-loop; other site 1167634003250 H-loop/switch region; other site 1167634003251 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1167634003252 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1167634003253 hypothetical protein; Provisional; Region: PRK07546 1167634003254 substrate-cofactor binding pocket; other site 1167634003255 homodimer interface [polypeptide binding]; other site 1167634003256 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1167634003257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634003258 catalytic residue [active] 1167634003259 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634003260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003261 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1167634003262 substrate binding pocket [chemical binding]; other site 1167634003263 dimerization interface [polypeptide binding]; other site 1167634003264 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1167634003265 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1167634003266 iron-sulfur cluster [ion binding]; other site 1167634003267 [2Fe-2S] cluster binding site [ion binding]; other site 1167634003268 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 1167634003269 putative alpha subunit interface [polypeptide binding]; other site 1167634003270 putative active site [active] 1167634003271 putative substrate binding site [chemical binding]; other site 1167634003272 Fe binding site [ion binding]; other site 1167634003273 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1167634003274 inter-subunit interface; other site 1167634003275 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1167634003276 [2Fe-2S] cluster binding site [ion binding]; other site 1167634003277 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1167634003278 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1167634003279 putative ATP binding site [chemical binding]; other site 1167634003280 putative substrate interface [chemical binding]; other site 1167634003281 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1167634003282 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634003283 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634003284 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1167634003285 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1167634003286 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1167634003287 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1167634003288 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1167634003289 Walker A/P-loop; other site 1167634003290 ATP binding site [chemical binding]; other site 1167634003291 Q-loop/lid; other site 1167634003292 ABC transporter signature motif; other site 1167634003293 Walker B; other site 1167634003294 D-loop; other site 1167634003295 H-loop/switch region; other site 1167634003296 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634003297 dimerization interface [polypeptide binding]; other site 1167634003298 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1167634003299 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1167634003300 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1167634003301 Walker A/P-loop; other site 1167634003302 ATP binding site [chemical binding]; other site 1167634003303 Q-loop/lid; other site 1167634003304 ABC transporter signature motif; other site 1167634003305 Walker B; other site 1167634003306 D-loop; other site 1167634003307 H-loop/switch region; other site 1167634003308 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1167634003309 FtsX-like permease family; Region: FtsX; pfam02687 1167634003310 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1167634003311 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634003312 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634003313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634003314 putative substrate translocation pore; other site 1167634003315 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634003316 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1167634003317 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1167634003318 putative active site pocket [active] 1167634003319 dimerization interface [polypeptide binding]; other site 1167634003320 putative catalytic residue [active] 1167634003321 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1167634003322 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1167634003323 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1167634003324 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1167634003325 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1167634003326 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1167634003327 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1167634003328 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1167634003329 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1167634003330 putative active site [active] 1167634003331 putative substrate binding site [chemical binding]; other site 1167634003332 putative cosubstrate binding site; other site 1167634003333 catalytic site [active] 1167634003334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634003335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003336 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634003337 putative effector binding pocket; other site 1167634003338 dimerization interface [polypeptide binding]; other site 1167634003339 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1167634003340 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1167634003341 active site 1167634003342 NAD binding site [chemical binding]; other site 1167634003343 metal binding site [ion binding]; metal-binding site 1167634003344 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1167634003345 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1167634003346 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634003347 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1167634003348 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1167634003349 phosphate binding site [ion binding]; other site 1167634003350 SnoaL-like domain; Region: SnoaL_4; pfam13577 1167634003351 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1167634003352 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1167634003353 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1167634003354 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1167634003355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003356 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 1167634003357 putative dimerization interface [polypeptide binding]; other site 1167634003358 putative substrate binding pocket [chemical binding]; other site 1167634003359 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634003360 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634003361 active site 1167634003362 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634003363 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634003364 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634003365 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1167634003366 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1167634003367 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1167634003368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634003369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634003371 dimerization interface [polypeptide binding]; other site 1167634003372 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634003373 Predicted permeases [General function prediction only]; Region: COG0679 1167634003374 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1167634003375 Class II fumarases; Region: Fumarase_classII; cd01362 1167634003376 active site 1167634003377 tetramer interface [polypeptide binding]; other site 1167634003378 AMIN domain; Region: AMIN; pfam11741 1167634003379 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1167634003380 active site 1167634003381 metal binding site [ion binding]; metal-binding site 1167634003382 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1167634003383 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634003384 N-terminal plug; other site 1167634003385 ligand-binding site [chemical binding]; other site 1167634003386 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1167634003387 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1167634003388 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1167634003389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634003390 Mg2+ binding site [ion binding]; other site 1167634003391 G-X-G motif; other site 1167634003392 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1167634003393 ATP binding site [chemical binding]; other site 1167634003394 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1167634003395 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1167634003396 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1167634003397 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1167634003398 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1167634003399 dimerization interface [polypeptide binding]; other site 1167634003400 putative ATP binding site [chemical binding]; other site 1167634003401 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 1167634003402 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1167634003403 Walker A motif; other site 1167634003404 ATP binding site [chemical binding]; other site 1167634003405 Walker B motif; other site 1167634003406 arginine finger; other site 1167634003407 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1167634003408 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1167634003409 poly(A) polymerase; Region: pcnB; TIGR01942 1167634003410 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1167634003411 active site 1167634003412 NTP binding site [chemical binding]; other site 1167634003413 metal binding triad [ion binding]; metal-binding site 1167634003414 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1167634003415 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1167634003416 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1167634003417 catalytic center binding site [active] 1167634003418 ATP binding site [chemical binding]; other site 1167634003419 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1167634003420 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1167634003421 substrate binding site [chemical binding]; other site 1167634003422 ATP binding site [chemical binding]; other site 1167634003423 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1167634003424 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634003425 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634003426 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1167634003427 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1167634003428 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1167634003429 active site 2 [active] 1167634003430 active site 1 [active] 1167634003431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634003432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003433 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1167634003434 putative dimerization interface [polypeptide binding]; other site 1167634003435 enoyl-CoA hydratase; Provisional; Region: PRK08140 1167634003436 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634003437 substrate binding site [chemical binding]; other site 1167634003438 oxyanion hole (OAH) forming residues; other site 1167634003439 trimer interface [polypeptide binding]; other site 1167634003440 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1167634003441 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1167634003442 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1167634003443 active site 1167634003444 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1167634003445 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1167634003446 FAD binding site [chemical binding]; other site 1167634003447 substrate binding site [chemical binding]; other site 1167634003448 catalytic base [active] 1167634003449 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1167634003450 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1167634003451 DUF35 OB-fold domain; Region: DUF35; pfam01796 1167634003452 thiolase; Provisional; Region: PRK06158 1167634003453 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1167634003454 active site 1167634003455 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1167634003456 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634003457 acyl-activating enzyme (AAE) consensus motif; other site 1167634003458 AMP binding site [chemical binding]; other site 1167634003459 active site 1167634003460 CoA binding site [chemical binding]; other site 1167634003461 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634003462 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1167634003463 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1167634003464 FMN binding site [chemical binding]; other site 1167634003465 substrate binding site [chemical binding]; other site 1167634003466 putative catalytic residue [active] 1167634003467 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634003468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634003469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003470 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1167634003471 putative dimerization interface [polypeptide binding]; other site 1167634003472 short chain dehydrogenase; Provisional; Region: PRK07791 1167634003473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634003474 NAD(P) binding site [chemical binding]; other site 1167634003475 active site 1167634003476 enoyl-CoA hydratase; Region: PLN02864 1167634003477 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1167634003478 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1167634003479 dimer interaction site [polypeptide binding]; other site 1167634003480 substrate-binding tunnel; other site 1167634003481 active site 1167634003482 catalytic site [active] 1167634003483 substrate binding site [chemical binding]; other site 1167634003484 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634003485 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634003486 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1167634003487 PAS domain; Region: PAS_9; pfam13426 1167634003488 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634003489 putative active site [active] 1167634003490 heme pocket [chemical binding]; other site 1167634003491 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634003492 PAS domain; Region: PAS_9; pfam13426 1167634003493 putative active site [active] 1167634003494 heme pocket [chemical binding]; other site 1167634003495 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634003496 dimer interface [polypeptide binding]; other site 1167634003497 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1167634003498 putative CheW interface [polypeptide binding]; other site 1167634003499 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1167634003500 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1167634003501 enoyl-CoA hydratase; Provisional; Region: PRK08252 1167634003502 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634003503 substrate binding site [chemical binding]; other site 1167634003504 oxyanion hole (OAH) forming residues; other site 1167634003505 trimer interface [polypeptide binding]; other site 1167634003506 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1167634003507 dimer interface [polypeptide binding]; other site 1167634003508 motif 1; other site 1167634003509 active site 1167634003510 motif 2; other site 1167634003511 motif 3; other site 1167634003512 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1167634003513 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1167634003514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634003515 active site 1167634003516 motif I; other site 1167634003517 motif II; other site 1167634003518 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1167634003519 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1167634003520 putative acyl-acceptor binding pocket; other site 1167634003521 Protein of unknown function DUF45; Region: DUF45; pfam01863 1167634003522 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1167634003523 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634003524 catalytic residue [active] 1167634003525 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1167634003526 dimer interface [polypeptide binding]; other site 1167634003527 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634003528 active site 1167634003529 metal binding site [ion binding]; metal-binding site 1167634003530 glutathione binding site [chemical binding]; other site 1167634003531 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1167634003532 active site 1167634003533 catalytic residues [active] 1167634003534 metal binding site [ion binding]; metal-binding site 1167634003535 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1167634003536 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634003537 active site 1167634003538 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1167634003539 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1167634003540 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1167634003541 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1167634003542 pyruvate kinase; Provisional; Region: PRK05826 1167634003543 domain interfaces; other site 1167634003544 active site 1167634003545 glycerate kinase; Region: TIGR00045 1167634003546 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1167634003547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634003548 S-adenosylmethionine binding site [chemical binding]; other site 1167634003549 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1167634003550 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1167634003551 SurA N-terminal domain; Region: SurA_N; pfam09312 1167634003552 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1167634003553 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1167634003554 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1167634003555 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1167634003556 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1167634003557 Phosphotransferase enzyme family; Region: APH; pfam01636 1167634003558 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1167634003559 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1167634003560 Substrate binding site; other site 1167634003561 metal-binding site 1167634003562 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1167634003563 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 1167634003564 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634003565 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1167634003566 MarR family; Region: MarR_2; pfam12802 1167634003567 MarR family; Region: MarR_2; cl17246 1167634003568 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 1167634003569 aromatic arch; other site 1167634003570 DCoH dimer interaction site [polypeptide binding]; other site 1167634003571 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1167634003572 DCoH tetramer interaction site [polypeptide binding]; other site 1167634003573 substrate binding site [chemical binding]; other site 1167634003574 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1167634003575 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1167634003576 ligand binding site [chemical binding]; other site 1167634003577 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1167634003578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634003579 motif II; other site 1167634003580 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1167634003581 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1167634003582 active site 1167634003583 metal binding site [ion binding]; metal-binding site 1167634003584 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1167634003585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634003586 NAD(P) binding site [chemical binding]; other site 1167634003587 active site 1167634003588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634003589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634003590 Cache domain; Region: Cache_1; pfam02743 1167634003591 HAMP domain; Region: HAMP; pfam00672 1167634003592 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634003593 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634003594 metal binding site [ion binding]; metal-binding site 1167634003595 active site 1167634003596 I-site; other site 1167634003597 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1167634003598 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1167634003599 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1167634003600 Sulfatase; Region: Sulfatase; pfam00884 1167634003601 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1167634003602 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1167634003603 Esterase/lipase [General function prediction only]; Region: COG1647 1167634003604 Cupin domain; Region: Cupin_2; cl17218 1167634003605 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634003606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634003607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634003608 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1167634003609 metal binding site 2 [ion binding]; metal-binding site 1167634003610 putative DNA binding helix; other site 1167634003611 metal binding site 1 [ion binding]; metal-binding site 1167634003612 dimer interface [polypeptide binding]; other site 1167634003613 structural Zn2+ binding site [ion binding]; other site 1167634003614 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634003615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003616 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634003617 dimerization interface [polypeptide binding]; other site 1167634003618 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1167634003619 dimer interface [polypeptide binding]; other site 1167634003620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634003621 dimerization interface [polypeptide binding]; other site 1167634003622 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634003623 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634003624 dimer interface [polypeptide binding]; other site 1167634003625 putative CheW interface [polypeptide binding]; other site 1167634003626 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1167634003627 homotrimer interaction site [polypeptide binding]; other site 1167634003628 putative active site [active] 1167634003629 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634003630 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634003631 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634003632 N-terminal plug; other site 1167634003633 ligand-binding site [chemical binding]; other site 1167634003634 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634003635 FecR protein; Region: FecR; pfam04773 1167634003636 RNA polymerase sigma factor; Provisional; Region: PRK12525 1167634003637 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1167634003638 DNA binding residues [nucleotide binding] 1167634003639 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1167634003640 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1167634003641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634003642 dimer interface [polypeptide binding]; other site 1167634003643 conserved gate region; other site 1167634003644 ABC-ATPase subunit interface; other site 1167634003645 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1167634003646 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1167634003647 Walker A/P-loop; other site 1167634003648 ATP binding site [chemical binding]; other site 1167634003649 Q-loop/lid; other site 1167634003650 ABC transporter signature motif; other site 1167634003651 Walker B; other site 1167634003652 D-loop; other site 1167634003653 H-loop/switch region; other site 1167634003654 NIL domain; Region: NIL; pfam09383 1167634003655 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1167634003656 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1167634003657 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 1167634003658 active site 1167634003659 catalytic site [active] 1167634003660 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1167634003661 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1167634003662 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1167634003663 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1167634003664 active site 1167634003665 dimerization interface [polypeptide binding]; other site 1167634003666 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1167634003667 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1167634003668 acyl-activating enzyme (AAE) consensus motif; other site 1167634003669 putative AMP binding site [chemical binding]; other site 1167634003670 putative active site [active] 1167634003671 putative CoA binding site [chemical binding]; other site 1167634003672 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1167634003673 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1167634003674 metal binding site [ion binding]; metal-binding site 1167634003675 putative dimer interface [polypeptide binding]; other site 1167634003676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003677 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1167634003678 putative dimerization interface [polypeptide binding]; other site 1167634003679 Predicted membrane protein [Function unknown]; Region: COG2855 1167634003680 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1167634003681 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1167634003682 MgtE intracellular N domain; Region: MgtE_N; smart00924 1167634003683 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1167634003684 Divalent cation transporter; Region: MgtE; cl00786 1167634003685 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1167634003686 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1167634003687 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1167634003688 putative active site pocket [active] 1167634003689 dimerization interface [polypeptide binding]; other site 1167634003690 putative catalytic residue [active] 1167634003691 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634003692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634003693 putative DNA binding site [nucleotide binding]; other site 1167634003694 putative Zn2+ binding site [ion binding]; other site 1167634003695 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634003696 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634003697 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1167634003698 putative NAD(P) binding site [chemical binding]; other site 1167634003699 putative active site [active] 1167634003700 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1167634003701 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1167634003702 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1167634003703 PYR/PP interface [polypeptide binding]; other site 1167634003704 dimer interface [polypeptide binding]; other site 1167634003705 TPP binding site [chemical binding]; other site 1167634003706 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1167634003707 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1167634003708 TPP-binding site [chemical binding]; other site 1167634003709 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634003710 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1167634003711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634003712 DNA-binding site [nucleotide binding]; DNA binding site 1167634003713 FCD domain; Region: FCD; pfam07729 1167634003714 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1167634003715 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1167634003716 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1167634003717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1167634003718 nucleotide binding region [chemical binding]; other site 1167634003719 ATP-binding site [chemical binding]; other site 1167634003720 SEC-C motif; Region: SEC-C; pfam02810 1167634003721 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1167634003722 Peptidase family M23; Region: Peptidase_M23; pfam01551 1167634003723 Protein of unknown function (DUF721); Region: DUF721; cl02324 1167634003724 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1167634003725 cell division protein FtsZ; Validated; Region: PRK09330 1167634003726 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1167634003727 nucleotide binding site [chemical binding]; other site 1167634003728 SulA interaction site; other site 1167634003729 cell division protein FtsA; Region: ftsA; TIGR01174 1167634003730 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1167634003731 nucleotide binding site [chemical binding]; other site 1167634003732 Cell division protein FtsA; Region: FtsA; pfam14450 1167634003733 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1167634003734 Cell division protein FtsQ; Region: FtsQ; pfam03799 1167634003735 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1167634003736 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1167634003737 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1167634003738 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1167634003739 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1167634003740 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1167634003741 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1167634003742 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1167634003743 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1167634003744 active site 1167634003745 homodimer interface [polypeptide binding]; other site 1167634003746 cell division protein FtsW; Region: ftsW; TIGR02614 1167634003747 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 1167634003748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1167634003749 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1167634003750 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1167634003751 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1167634003752 Mg++ binding site [ion binding]; other site 1167634003753 putative catalytic motif [active] 1167634003754 putative substrate binding site [chemical binding]; other site 1167634003755 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 1167634003756 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1167634003757 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1167634003758 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1167634003759 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1167634003760 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1167634003761 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1167634003762 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1167634003763 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1167634003764 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1167634003765 cell division protein FtsL; Region: ftsL_broad; TIGR02209 1167634003766 MraW methylase family; Region: Methyltransf_5; cl17771 1167634003767 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1167634003768 cell division protein MraZ; Reviewed; Region: PRK00326 1167634003769 MraZ protein; Region: MraZ; pfam02381 1167634003770 MraZ protein; Region: MraZ; pfam02381 1167634003771 ABC transporter ATPase component; Reviewed; Region: PRK11147 1167634003772 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634003773 ABC transporter; Region: ABC_tran_2; pfam12848 1167634003774 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634003775 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1167634003776 active site 1167634003777 substrate binding pocket [chemical binding]; other site 1167634003778 dimer interface [polypeptide binding]; other site 1167634003779 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1167634003780 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1167634003781 metal binding site [ion binding]; metal-binding site 1167634003782 putative dimer interface [polypeptide binding]; other site 1167634003783 SWI complex, BAF60b domains; Region: SWIB; smart00151 1167634003784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003785 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1167634003786 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1167634003787 dimerization interface [polypeptide binding]; other site 1167634003788 substrate binding pocket [chemical binding]; other site 1167634003789 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634003790 Predicted membrane protein [Function unknown]; Region: COG3671 1167634003791 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634003792 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634003793 putative DNA binding site [nucleotide binding]; other site 1167634003794 putative Zn2+ binding site [ion binding]; other site 1167634003795 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634003796 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1167634003797 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1167634003798 dimer interface [polypeptide binding]; other site 1167634003799 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1167634003800 active site 1167634003801 Fe binding site [ion binding]; other site 1167634003802 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1167634003803 Cytochrome c; Region: Cytochrom_C; cl11414 1167634003804 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1167634003805 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1167634003806 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1167634003807 Cell division protein ZapA; Region: ZapA; pfam05164 1167634003808 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1167634003809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1167634003810 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1167634003811 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1167634003812 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1167634003813 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1167634003814 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1167634003815 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1167634003816 LysR family transcriptional regulator; Provisional; Region: PRK14997 1167634003817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003818 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1167634003819 putative effector binding pocket; other site 1167634003820 putative dimerization interface [polypeptide binding]; other site 1167634003821 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1167634003822 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1167634003823 putative ligand binding site [chemical binding]; other site 1167634003824 NAD binding site [chemical binding]; other site 1167634003825 dimerization interface [polypeptide binding]; other site 1167634003826 catalytic site [active] 1167634003827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1167634003828 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1167634003829 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1167634003830 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634003831 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634003832 dimer interface [polypeptide binding]; other site 1167634003833 phosphorylation site [posttranslational modification] 1167634003834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634003835 ATP binding site [chemical binding]; other site 1167634003836 Mg2+ binding site [ion binding]; other site 1167634003837 G-X-G motif; other site 1167634003838 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1167634003839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634003840 active site 1167634003841 phosphorylation site [posttranslational modification] 1167634003842 intermolecular recognition site; other site 1167634003843 dimerization interface [polypeptide binding]; other site 1167634003844 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634003845 DNA binding site [nucleotide binding] 1167634003846 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1167634003847 putative active site [active] 1167634003848 Ap4A binding site [chemical binding]; other site 1167634003849 nudix motif; other site 1167634003850 putative metal binding site [ion binding]; other site 1167634003851 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1167634003852 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1167634003853 dimer interface [polypeptide binding]; other site 1167634003854 motif 1; other site 1167634003855 active site 1167634003856 motif 2; other site 1167634003857 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1167634003858 putative deacylase active site [active] 1167634003859 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1167634003860 active site 1167634003861 motif 3; other site 1167634003862 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1167634003863 anticodon binding site; other site 1167634003864 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1167634003865 active site 1167634003866 TolQ protein; Region: tolQ; TIGR02796 1167634003867 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1167634003868 TolR protein; Region: tolR; TIGR02801 1167634003869 TolA protein; Region: tolA_full; TIGR02794 1167634003870 TonB C terminal; Region: TonB_2; pfam13103 1167634003871 translocation protein TolB; Provisional; Region: tolB; PRK02889 1167634003872 TolB amino-terminal domain; Region: TolB_N; pfam04052 1167634003873 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1167634003874 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1167634003875 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1167634003876 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1167634003877 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1167634003878 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1167634003879 ligand binding site [chemical binding]; other site 1167634003880 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1167634003881 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1167634003882 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1167634003883 ABC-ATPase subunit interface; other site 1167634003884 dimer interface [polypeptide binding]; other site 1167634003885 putative PBP binding regions; other site 1167634003886 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1167634003887 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1167634003888 Walker A/P-loop; other site 1167634003889 ATP binding site [chemical binding]; other site 1167634003890 Q-loop/lid; other site 1167634003891 ABC transporter signature motif; other site 1167634003892 Walker B; other site 1167634003893 D-loop; other site 1167634003894 H-loop/switch region; other site 1167634003895 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1167634003896 putative deacylase active site [active] 1167634003897 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1167634003898 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1167634003899 catalytic site [active] 1167634003900 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634003901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634003902 putative DNA binding site [nucleotide binding]; other site 1167634003903 putative Zn2+ binding site [ion binding]; other site 1167634003904 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634003905 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634003906 EamA-like transporter family; Region: EamA; pfam00892 1167634003907 EamA-like transporter family; Region: EamA; pfam00892 1167634003908 elongation factor G; Reviewed; Region: PRK00007 1167634003909 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1167634003910 G1 box; other site 1167634003911 putative GEF interaction site [polypeptide binding]; other site 1167634003912 GTP/Mg2+ binding site [chemical binding]; other site 1167634003913 Switch I region; other site 1167634003914 G2 box; other site 1167634003915 G3 box; other site 1167634003916 Switch II region; other site 1167634003917 G4 box; other site 1167634003918 G5 box; other site 1167634003919 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1167634003920 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1167634003921 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1167634003922 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1167634003923 Ligand Binding Site [chemical binding]; other site 1167634003924 Putative phosphatase (DUF442); Region: DUF442; cl17385 1167634003925 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634003926 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634003927 DNA-binding site [nucleotide binding]; DNA binding site 1167634003928 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634003929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634003930 homodimer interface [polypeptide binding]; other site 1167634003931 catalytic residue [active] 1167634003932 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634003933 EamA-like transporter family; Region: EamA; pfam00892 1167634003934 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634003935 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1167634003936 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1167634003937 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634003938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003939 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1167634003940 putative dimerization interface [polypeptide binding]; other site 1167634003941 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1167634003942 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1167634003943 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1167634003944 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1167634003945 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1167634003946 inhibitor site; inhibition site 1167634003947 active site 1167634003948 dimer interface [polypeptide binding]; other site 1167634003949 catalytic residue [active] 1167634003950 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634003951 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634003952 Walker A/P-loop; other site 1167634003953 ATP binding site [chemical binding]; other site 1167634003954 Q-loop/lid; other site 1167634003955 ABC transporter signature motif; other site 1167634003956 Walker B; other site 1167634003957 D-loop; other site 1167634003958 H-loop/switch region; other site 1167634003959 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634003960 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634003961 Walker A/P-loop; other site 1167634003962 ATP binding site [chemical binding]; other site 1167634003963 Q-loop/lid; other site 1167634003964 ABC transporter signature motif; other site 1167634003965 Walker B; other site 1167634003966 D-loop; other site 1167634003967 H-loop/switch region; other site 1167634003968 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634003969 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1167634003970 putative ligand binding site [chemical binding]; other site 1167634003971 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634003972 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634003973 TM-ABC transporter signature motif; other site 1167634003974 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634003975 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634003976 TM-ABC transporter signature motif; other site 1167634003977 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634003978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634003979 DNA-binding site [nucleotide binding]; DNA binding site 1167634003980 FCD domain; Region: FCD; cl11656 1167634003981 Predicted membrane protein [Function unknown]; Region: COG4125 1167634003982 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1167634003983 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1167634003984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634003985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634003986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634003987 dimerization interface [polypeptide binding]; other site 1167634003988 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 1167634003989 putative active site [active] 1167634003990 YdjC motif; other site 1167634003991 Mg binding site [ion binding]; other site 1167634003992 putative homodimer interface [polypeptide binding]; other site 1167634003993 GtrA-like protein; Region: GtrA; pfam04138 1167634003994 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1167634003995 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1167634003996 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1167634003997 Ligand binding site; other site 1167634003998 Putative Catalytic site; other site 1167634003999 DXD motif; other site 1167634004000 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1167634004001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634004002 Coenzyme A binding pocket [chemical binding]; other site 1167634004003 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1167634004004 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1167634004005 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 1167634004006 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1167634004007 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1167634004008 active site 1167634004009 catalytic site [active] 1167634004010 substrate binding site [chemical binding]; other site 1167634004011 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1167634004012 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1167634004013 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634004014 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634004015 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1167634004016 RNA/DNA hybrid binding site [nucleotide binding]; other site 1167634004017 active site 1167634004018 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1167634004019 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1167634004020 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1167634004021 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1167634004022 catalytic residue [active] 1167634004023 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1167634004024 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1167634004025 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1167634004026 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1167634004027 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 1167634004028 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1167634004029 NAD binding site [chemical binding]; other site 1167634004030 homotetramer interface [polypeptide binding]; other site 1167634004031 homodimer interface [polypeptide binding]; other site 1167634004032 substrate binding site [chemical binding]; other site 1167634004033 active site 1167634004034 OsmC-like protein; Region: OsmC; pfam02566 1167634004035 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1167634004036 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1167634004037 putative metal binding site [ion binding]; other site 1167634004038 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634004039 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 1167634004040 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1167634004041 dimerization interface [polypeptide binding]; other site 1167634004042 active site 1167634004043 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1167634004044 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1167634004045 anti sigma factor interaction site; other site 1167634004046 regulatory phosphorylation site [posttranslational modification]; other site 1167634004047 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1167634004048 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1167634004049 alanine racemase; Reviewed; Region: dadX; PRK03646 1167634004050 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1167634004051 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1167634004052 catalytic residue [active] 1167634004053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634004054 putative substrate translocation pore; other site 1167634004055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634004056 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1167634004057 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1167634004058 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1167634004059 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1167634004060 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1167634004061 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634004062 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634004063 DNA binding residues [nucleotide binding] 1167634004064 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 1167634004065 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1167634004066 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1167634004067 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1167634004068 Tir chaperone protein (CesT) family; Region: CesT; cl08444 1167634004069 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 1167634004070 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1167634004071 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 1167634004072 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 1167634004073 type III secretion system protein YscR; Provisional; Region: PRK12797 1167634004074 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1167634004075 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1167634004076 type III secretion system ATPase; Provisional; Region: PRK06936 1167634004077 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1167634004078 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1167634004079 Walker A motif/ATP binding site; other site 1167634004080 Walker B motif; other site 1167634004081 Flagellar assembly protein FliH; Region: FliH; pfam02108 1167634004082 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 1167634004083 Type III secretion needle MxiH like; Region: MxiH; cl09641 1167634004084 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1167634004085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1167634004086 binding surface 1167634004087 TPR motif; other site 1167634004088 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 1167634004089 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1167634004090 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1167634004091 binding surface 1167634004092 TPR motif; other site 1167634004093 HrpJ-like domain; Region: HrpJ; cl15454 1167634004094 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 1167634004095 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 1167634004096 Type III secretion system YscX (type_III_YscX); Region: Type_III_YscX; cl09710 1167634004097 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1167634004098 FHIPEP family; Region: FHIPEP; pfam00771 1167634004099 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1167634004100 Type III secretion needle MxiH like; Region: MxiH; cl09641 1167634004101 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1167634004102 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1167634004103 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1167634004104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634004105 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1167634004106 putative dimerization interface [polypeptide binding]; other site 1167634004107 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634004108 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1167634004109 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1167634004110 catalytic residues [active] 1167634004111 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 1167634004112 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1167634004113 active site 1 [active] 1167634004114 dimer interface [polypeptide binding]; other site 1167634004115 hexamer interface [polypeptide binding]; other site 1167634004116 active site 2 [active] 1167634004117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634004118 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634004119 dimerization interface [polypeptide binding]; other site 1167634004120 SpoVR family protein; Provisional; Region: PRK11767 1167634004121 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1167634004122 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1167634004123 metal ion-dependent adhesion site (MIDAS); other site 1167634004124 PrkA family serine protein kinase; Provisional; Region: PRK15455 1167634004125 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1167634004126 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1167634004127 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1167634004128 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1167634004129 catalytic motif [active] 1167634004130 Zn binding site [ion binding]; other site 1167634004131 RibD C-terminal domain; Region: RibD_C; cl17279 1167634004132 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1167634004133 Isochorismatase family; Region: Isochorismatase; pfam00857 1167634004134 catalytic triad [active] 1167634004135 conserved cis-peptide bond; other site 1167634004136 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1167634004137 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1167634004138 conserved cys residue [active] 1167634004139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634004140 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1167634004141 ATP cone domain; Region: ATP-cone; pfam03477 1167634004142 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1167634004143 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1167634004144 dimer interface [polypeptide binding]; other site 1167634004145 active site 1167634004146 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1167634004147 folate binding site [chemical binding]; other site 1167634004148 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634004149 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1167634004150 substrate binding site [chemical binding]; other site 1167634004151 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1167634004152 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1167634004153 active site 1167634004154 HIGH motif; other site 1167634004155 dimer interface [polypeptide binding]; other site 1167634004156 KMSKS motif; other site 1167634004157 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1167634004158 RNA binding surface [nucleotide binding]; other site 1167634004159 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1167634004160 Peptidase family M23; Region: Peptidase_M23; pfam01551 1167634004161 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1167634004162 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1167634004163 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1167634004164 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1167634004165 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1167634004166 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1167634004167 23S rRNA interface [nucleotide binding]; other site 1167634004168 L3 interface [polypeptide binding]; other site 1167634004169 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634004170 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634004171 Walker A/P-loop; other site 1167634004172 ATP binding site [chemical binding]; other site 1167634004173 Q-loop/lid; other site 1167634004174 ABC transporter signature motif; other site 1167634004175 Walker B; other site 1167634004176 D-loop; other site 1167634004177 H-loop/switch region; other site 1167634004178 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634004179 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634004180 Walker A/P-loop; other site 1167634004181 ATP binding site [chemical binding]; other site 1167634004182 Q-loop/lid; other site 1167634004183 ABC transporter signature motif; other site 1167634004184 Walker B; other site 1167634004185 D-loop; other site 1167634004186 H-loop/switch region; other site 1167634004187 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634004188 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634004189 TM-ABC transporter signature motif; other site 1167634004190 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634004191 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634004192 TM-ABC transporter signature motif; other site 1167634004193 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1167634004194 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1167634004195 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1167634004196 peptidase PmbA; Provisional; Region: PRK11040 1167634004197 hypothetical protein; Provisional; Region: PRK05255 1167634004198 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1167634004199 putative hydrolase; Provisional; Region: PRK11460 1167634004200 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1167634004201 NMT1/THI5 like; Region: NMT1; pfam09084 1167634004202 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1167634004203 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634004204 Walker A/P-loop; other site 1167634004205 ATP binding site [chemical binding]; other site 1167634004206 Q-loop/lid; other site 1167634004207 ABC transporter signature motif; other site 1167634004208 Walker B; other site 1167634004209 D-loop; other site 1167634004210 H-loop/switch region; other site 1167634004211 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634004212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634004213 dimer interface [polypeptide binding]; other site 1167634004214 conserved gate region; other site 1167634004215 putative PBP binding loops; other site 1167634004216 ABC-ATPase subunit interface; other site 1167634004217 Isochorismatase family; Region: Isochorismatase; pfam00857 1167634004218 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1167634004219 catalytic triad [active] 1167634004220 conserved cis-peptide bond; other site 1167634004221 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1167634004222 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1167634004223 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1167634004224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1167634004225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634004226 Coenzyme A binding pocket [chemical binding]; other site 1167634004227 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1167634004228 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1167634004229 HIGH motif; other site 1167634004230 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1167634004231 active site 1167634004232 KMSKS motif; other site 1167634004233 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1167634004234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634004235 putative substrate translocation pore; other site 1167634004236 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634004237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634004238 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1167634004239 putative dimerization interface [polypeptide binding]; other site 1167634004240 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1167634004241 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634004242 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634004243 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634004244 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634004245 putative DNA binding site [nucleotide binding]; other site 1167634004246 putative Zn2+ binding site [ion binding]; other site 1167634004247 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634004248 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 1167634004249 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1167634004250 dimer interface [polypeptide binding]; other site 1167634004251 PYR/PP interface [polypeptide binding]; other site 1167634004252 TPP binding site [chemical binding]; other site 1167634004253 substrate binding site [chemical binding]; other site 1167634004254 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1167634004255 TPP-binding site [chemical binding]; other site 1167634004256 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1167634004257 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1167634004258 ATP cone domain; Region: ATP-cone; pfam03477 1167634004259 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1167634004260 active site 1167634004261 dimer interface [polypeptide binding]; other site 1167634004262 catalytic residues [active] 1167634004263 effector binding site; other site 1167634004264 R2 peptide binding site; other site 1167634004265 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1167634004266 dimer interface [polypeptide binding]; other site 1167634004267 putative radical transfer pathway; other site 1167634004268 diiron center [ion binding]; other site 1167634004269 tyrosyl radical; other site 1167634004270 YGGT family; Region: YGGT; pfam02325 1167634004271 YGGT family; Region: YGGT; pfam02325 1167634004272 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1167634004273 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1167634004274 acyl-activating enzyme (AAE) consensus motif; other site 1167634004275 AMP binding site [chemical binding]; other site 1167634004276 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1167634004277 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1167634004278 DltD C-terminal region; Region: DltD_C; pfam04914 1167634004279 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1167634004280 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1167634004281 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1167634004282 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1167634004283 substrate binding site [chemical binding]; other site 1167634004284 ATP binding site [chemical binding]; other site 1167634004285 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1167634004286 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1167634004287 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1167634004288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634004289 S-adenosylmethionine binding site [chemical binding]; other site 1167634004290 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1167634004291 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1167634004292 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1167634004293 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1167634004294 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1167634004295 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1167634004296 carboxyltransferase (CT) interaction site; other site 1167634004297 biotinylation site [posttranslational modification]; other site 1167634004298 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1167634004299 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1167634004300 trimer interface [polypeptide binding]; other site 1167634004301 active site 1167634004302 dimer interface [polypeptide binding]; other site 1167634004303 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1167634004304 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1167634004305 catalytic residues [active] 1167634004306 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1167634004307 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1167634004308 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1167634004309 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1167634004310 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1167634004311 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634004312 RNB domain; Region: RNB; pfam00773 1167634004313 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1167634004314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634004315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634004316 active site 1167634004317 phosphorylation site [posttranslational modification] 1167634004318 intermolecular recognition site; other site 1167634004319 dimerization interface [polypeptide binding]; other site 1167634004320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634004321 DNA binding site [nucleotide binding] 1167634004322 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1167634004323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634004324 dimer interface [polypeptide binding]; other site 1167634004325 phosphorylation site [posttranslational modification] 1167634004326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634004327 ATP binding site [chemical binding]; other site 1167634004328 Mg2+ binding site [ion binding]; other site 1167634004329 G-X-G motif; other site 1167634004330 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1167634004331 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1167634004332 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1167634004333 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1167634004334 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1167634004335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634004336 dimer interface [polypeptide binding]; other site 1167634004337 conserved gate region; other site 1167634004338 ABC-ATPase subunit interface; other site 1167634004339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634004340 dimer interface [polypeptide binding]; other site 1167634004341 conserved gate region; other site 1167634004342 putative PBP binding loops; other site 1167634004343 ABC-ATPase subunit interface; other site 1167634004344 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1167634004345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634004346 Walker A/P-loop; other site 1167634004347 ATP binding site [chemical binding]; other site 1167634004348 Q-loop/lid; other site 1167634004349 ABC transporter signature motif; other site 1167634004350 Walker B; other site 1167634004351 D-loop; other site 1167634004352 H-loop/switch region; other site 1167634004353 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1167634004354 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1167634004355 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1167634004356 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1167634004357 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1167634004358 shikimate binding site; other site 1167634004359 NAD(P) binding site [chemical binding]; other site 1167634004360 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1167634004361 Transglycosylase; Region: Transgly; cl17702 1167634004362 Predicted permeases [General function prediction only]; Region: COG0795 1167634004363 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1167634004364 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1167634004365 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1167634004366 active site 1167634004367 metal binding site [ion binding]; metal-binding site 1167634004368 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634004369 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634004370 Walker A/P-loop; other site 1167634004371 ATP binding site [chemical binding]; other site 1167634004372 Q-loop/lid; other site 1167634004373 ABC transporter signature motif; other site 1167634004374 Walker B; other site 1167634004375 D-loop; other site 1167634004376 H-loop/switch region; other site 1167634004377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634004378 dimer interface [polypeptide binding]; other site 1167634004379 conserved gate region; other site 1167634004380 putative PBP binding loops; other site 1167634004381 ABC-ATPase subunit interface; other site 1167634004382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634004383 dimer interface [polypeptide binding]; other site 1167634004384 conserved gate region; other site 1167634004385 putative PBP binding loops; other site 1167634004386 ABC-ATPase subunit interface; other site 1167634004387 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634004388 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634004389 substrate binding pocket [chemical binding]; other site 1167634004390 membrane-bound complex binding site; other site 1167634004391 hinge residues; other site 1167634004392 aspartate aminotransferase; Provisional; Region: PRK05764 1167634004393 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634004394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634004395 homodimer interface [polypeptide binding]; other site 1167634004396 catalytic residue [active] 1167634004397 hypothetical protein; Validated; Region: PRK06201 1167634004398 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1167634004399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634004400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634004401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634004402 dimerization interface [polypeptide binding]; other site 1167634004403 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1167634004404 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1167634004405 putative acyl-acceptor binding pocket; other site 1167634004406 dihydroorotase; Provisional; Region: PRK07627 1167634004407 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634004408 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634004409 active site 1167634004410 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1167634004411 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1167634004412 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1167634004413 hypothetical protein; Validated; Region: PRK00228 1167634004414 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1167634004415 Rubredoxin; Region: Rubredoxin; pfam00301 1167634004416 iron binding site [ion binding]; other site 1167634004417 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1167634004418 substrate binding site [chemical binding]; other site 1167634004419 ATP binding site [chemical binding]; other site 1167634004420 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1167634004421 thiamine phosphate binding site [chemical binding]; other site 1167634004422 active site 1167634004423 pyrophosphate binding site [ion binding]; other site 1167634004424 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1167634004425 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1167634004426 inhibitor-cofactor binding pocket; inhibition site 1167634004427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634004428 catalytic residue [active] 1167634004429 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1167634004430 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1167634004431 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1167634004432 catalytic residue [active] 1167634004433 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1167634004434 short chain dehydrogenase; Provisional; Region: PRK08265 1167634004435 classical (c) SDRs; Region: SDR_c; cd05233 1167634004436 NAD(P) binding site [chemical binding]; other site 1167634004437 active site 1167634004438 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1167634004439 Isochorismatase family; Region: Isochorismatase; pfam00857 1167634004440 catalytic triad [active] 1167634004441 conserved cis-peptide bond; other site 1167634004442 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1167634004443 inter-subunit interface; other site 1167634004444 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 1167634004445 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1167634004446 iron-sulfur cluster [ion binding]; other site 1167634004447 [2Fe-2S] cluster binding site [ion binding]; other site 1167634004448 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1167634004449 putative alpha subunit interface [polypeptide binding]; other site 1167634004450 putative active site [active] 1167634004451 putative substrate binding site [chemical binding]; other site 1167634004452 Fe binding site [ion binding]; other site 1167634004453 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1167634004454 SnoaL-like domain; Region: SnoaL_2; pfam12680 1167634004455 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634004456 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 1167634004457 putative ligand binding site [chemical binding]; other site 1167634004458 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634004459 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634004460 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1167634004461 homotrimer interaction site [polypeptide binding]; other site 1167634004462 putative active site [active] 1167634004463 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1167634004464 active site 1167634004465 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634004466 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1167634004467 acyl-activating enzyme (AAE) consensus motif; other site 1167634004468 AMP binding site [chemical binding]; other site 1167634004469 active site 1167634004470 CoA binding site [chemical binding]; other site 1167634004471 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634004472 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 1167634004473 active site 1167634004474 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1167634004475 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634004476 substrate binding site [chemical binding]; other site 1167634004477 oxyanion hole (OAH) forming residues; other site 1167634004478 trimer interface [polypeptide binding]; other site 1167634004479 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634004480 classical (c) SDRs; Region: SDR_c; cd05233 1167634004481 NAD(P) binding site [chemical binding]; other site 1167634004482 active site 1167634004483 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 1167634004484 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634004485 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1167634004486 active site 1167634004487 FMN binding site [chemical binding]; other site 1167634004488 substrate binding site [chemical binding]; other site 1167634004489 homotetramer interface [polypeptide binding]; other site 1167634004490 catalytic residue [active] 1167634004491 PAS domain; Region: PAS_9; pfam13426 1167634004492 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1167634004493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634004494 PAS domain; Region: PAS_9; pfam13426 1167634004495 putative active site [active] 1167634004496 heme pocket [chemical binding]; other site 1167634004497 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1167634004498 GAF domain; Region: GAF; cl17456 1167634004499 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634004500 metal binding site [ion binding]; metal-binding site 1167634004501 active site 1167634004502 I-site; other site 1167634004503 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634004504 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634004505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634004506 metal binding site [ion binding]; metal-binding site 1167634004507 active site 1167634004508 I-site; other site 1167634004509 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 1167634004510 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634004511 dimerization interface [polypeptide binding]; other site 1167634004512 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1167634004513 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1167634004514 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634004515 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634004516 Walker A/P-loop; other site 1167634004517 ATP binding site [chemical binding]; other site 1167634004518 Q-loop/lid; other site 1167634004519 ABC transporter signature motif; other site 1167634004520 Walker B; other site 1167634004521 D-loop; other site 1167634004522 H-loop/switch region; other site 1167634004523 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634004524 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634004525 Walker A/P-loop; other site 1167634004526 ATP binding site [chemical binding]; other site 1167634004527 Q-loop/lid; other site 1167634004528 ABC transporter signature motif; other site 1167634004529 Walker B; other site 1167634004530 D-loop; other site 1167634004531 H-loop/switch region; other site 1167634004532 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634004533 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634004534 TM-ABC transporter signature motif; other site 1167634004535 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634004536 TM-ABC transporter signature motif; other site 1167634004537 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634004538 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 1167634004539 putative ligand binding site [chemical binding]; other site 1167634004540 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1167634004541 MarR family; Region: MarR; pfam01047 1167634004542 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1167634004543 heterotetramer interface [polypeptide binding]; other site 1167634004544 active site pocket [active] 1167634004545 cleavage site 1167634004546 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1167634004547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634004548 Walker A motif; other site 1167634004549 ATP binding site [chemical binding]; other site 1167634004550 Walker B motif; other site 1167634004551 hypothetical protein; Provisional; Region: PRK08999 1167634004552 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1167634004553 active site 1167634004554 8-oxo-dGMP binding site [chemical binding]; other site 1167634004555 nudix motif; other site 1167634004556 metal binding site [ion binding]; metal-binding site 1167634004557 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1167634004558 thiamine phosphate binding site [chemical binding]; other site 1167634004559 active site 1167634004560 pyrophosphate binding site [ion binding]; other site 1167634004561 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1167634004562 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1167634004563 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1167634004564 Walker A/P-loop; other site 1167634004565 ATP binding site [chemical binding]; other site 1167634004566 Q-loop/lid; other site 1167634004567 ABC transporter signature motif; other site 1167634004568 Walker B; other site 1167634004569 D-loop; other site 1167634004570 H-loop/switch region; other site 1167634004571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634004572 dimer interface [polypeptide binding]; other site 1167634004573 conserved gate region; other site 1167634004574 putative PBP binding loops; other site 1167634004575 ABC-ATPase subunit interface; other site 1167634004576 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1167634004577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634004578 dimer interface [polypeptide binding]; other site 1167634004579 conserved gate region; other site 1167634004580 putative PBP binding loops; other site 1167634004581 ABC-ATPase subunit interface; other site 1167634004582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634004583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634004584 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1167634004585 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634004586 active site 1167634004587 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634004588 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1167634004589 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1167634004590 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1167634004591 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634004592 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1167634004593 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1167634004594 Protein export membrane protein; Region: SecD_SecF; cl14618 1167634004595 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1167634004596 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1167634004597 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634004598 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634004599 hypothetical protein; Provisional; Region: PRK05287 1167634004600 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1167634004601 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1167634004602 CoA-binding site [chemical binding]; other site 1167634004603 ATP-binding [chemical binding]; other site 1167634004604 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1167634004605 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1167634004606 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1167634004607 NlpE N-terminal domain; Region: NlpE; pfam04170 1167634004608 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634004609 DNA binding residues [nucleotide binding] 1167634004610 dimerization interface [polypeptide binding]; other site 1167634004611 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1167634004612 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1167634004613 active site 1167634004614 ATP-binding site [chemical binding]; other site 1167634004615 pantoate-binding site; other site 1167634004616 HXXH motif; other site 1167634004617 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1167634004618 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 1167634004619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634004620 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634004621 putative substrate translocation pore; other site 1167634004622 glycerol kinase; Provisional; Region: glpK; PRK00047 1167634004623 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1167634004624 N- and C-terminal domain interface [polypeptide binding]; other site 1167634004625 active site 1167634004626 MgATP binding site [chemical binding]; other site 1167634004627 catalytic site [active] 1167634004628 metal binding site [ion binding]; metal-binding site 1167634004629 glycerol binding site [chemical binding]; other site 1167634004630 homotetramer interface [polypeptide binding]; other site 1167634004631 homodimer interface [polypeptide binding]; other site 1167634004632 FBP binding site [chemical binding]; other site 1167634004633 protein IIAGlc interface [polypeptide binding]; other site 1167634004634 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1167634004635 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634004636 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634004637 dimerization interface [polypeptide binding]; other site 1167634004638 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1167634004639 Cupin domain; Region: Cupin_2; pfam07883 1167634004640 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1167634004641 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1167634004642 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1167634004643 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1167634004644 C-terminal domain interface [polypeptide binding]; other site 1167634004645 GSH binding site (G-site) [chemical binding]; other site 1167634004646 putative dimer interface [polypeptide binding]; other site 1167634004647 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1167634004648 dimer interface [polypeptide binding]; other site 1167634004649 N-terminal domain interface [polypeptide binding]; other site 1167634004650 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1167634004651 Chorismate mutase type II; Region: CM_2; pfam01817 1167634004652 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634004653 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1167634004654 salicylate hydroxylase; Provisional; Region: PRK08163 1167634004655 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634004656 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634004657 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 1167634004658 putative ligand binding site [chemical binding]; other site 1167634004659 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634004660 TM-ABC transporter signature motif; other site 1167634004661 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634004662 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634004663 TM-ABC transporter signature motif; other site 1167634004664 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634004665 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634004666 Walker A/P-loop; other site 1167634004667 ATP binding site [chemical binding]; other site 1167634004668 Q-loop/lid; other site 1167634004669 ABC transporter signature motif; other site 1167634004670 Walker B; other site 1167634004671 D-loop; other site 1167634004672 H-loop/switch region; other site 1167634004673 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634004674 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634004675 Walker A/P-loop; other site 1167634004676 ATP binding site [chemical binding]; other site 1167634004677 Q-loop/lid; other site 1167634004678 ABC transporter signature motif; other site 1167634004679 Walker B; other site 1167634004680 D-loop; other site 1167634004681 H-loop/switch region; other site 1167634004682 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1167634004683 dimer interface [polypeptide binding]; other site 1167634004684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634004685 ligand binding site [chemical binding]; other site 1167634004686 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634004687 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634004688 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634004689 Walker A/P-loop; other site 1167634004690 ATP binding site [chemical binding]; other site 1167634004691 Q-loop/lid; other site 1167634004692 ABC transporter signature motif; other site 1167634004693 Walker B; other site 1167634004694 D-loop; other site 1167634004695 H-loop/switch region; other site 1167634004696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634004697 dimer interface [polypeptide binding]; other site 1167634004698 conserved gate region; other site 1167634004699 putative PBP binding loops; other site 1167634004700 ABC-ATPase subunit interface; other site 1167634004701 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1167634004702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634004703 conserved gate region; other site 1167634004704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634004705 putative PBP binding loops; other site 1167634004706 dimer interface [polypeptide binding]; other site 1167634004707 ABC-ATPase subunit interface; other site 1167634004708 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1167634004709 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634004710 substrate binding pocket [chemical binding]; other site 1167634004711 membrane-bound complex binding site; other site 1167634004712 hinge residues; other site 1167634004713 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1167634004714 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1167634004715 Walker A/P-loop; other site 1167634004716 ATP binding site [chemical binding]; other site 1167634004717 Q-loop/lid; other site 1167634004718 ABC transporter signature motif; other site 1167634004719 Walker B; other site 1167634004720 D-loop; other site 1167634004721 H-loop/switch region; other site 1167634004722 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1167634004723 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 1167634004724 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1167634004725 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1167634004726 conserved cys residue [active] 1167634004727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634004728 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1167634004729 active site 1167634004730 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1167634004731 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1167634004732 dimer interface [polypeptide binding]; other site 1167634004733 PYR/PP interface [polypeptide binding]; other site 1167634004734 TPP binding site [chemical binding]; other site 1167634004735 substrate binding site [chemical binding]; other site 1167634004736 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1167634004737 TPP-binding site [chemical binding]; other site 1167634004738 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1167634004739 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1167634004740 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1167634004741 minor groove reading motif; other site 1167634004742 helix-hairpin-helix signature motif; other site 1167634004743 substrate binding pocket [chemical binding]; other site 1167634004744 active site 1167634004745 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1167634004746 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1167634004747 DNA binding and oxoG recognition site [nucleotide binding] 1167634004748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634004749 salt bridge; other site 1167634004750 non-specific DNA binding site [nucleotide binding]; other site 1167634004751 sequence-specific DNA binding site [nucleotide binding]; other site 1167634004752 indole acetimide hydrolase; Validated; Region: PRK07488 1167634004753 Amidase; Region: Amidase; cl11426 1167634004754 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1167634004755 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1167634004756 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1167634004757 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1167634004758 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1167634004759 putative active site pocket [active] 1167634004760 putative metal binding site [ion binding]; other site 1167634004761 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634004762 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634004763 Walker A/P-loop; other site 1167634004764 ATP binding site [chemical binding]; other site 1167634004765 Q-loop/lid; other site 1167634004766 ABC transporter signature motif; other site 1167634004767 Walker B; other site 1167634004768 D-loop; other site 1167634004769 H-loop/switch region; other site 1167634004770 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1167634004771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634004772 dimer interface [polypeptide binding]; other site 1167634004773 conserved gate region; other site 1167634004774 putative PBP binding loops; other site 1167634004775 ABC-ATPase subunit interface; other site 1167634004776 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1167634004777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634004778 dimer interface [polypeptide binding]; other site 1167634004779 conserved gate region; other site 1167634004780 putative PBP binding loops; other site 1167634004781 ABC-ATPase subunit interface; other site 1167634004782 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1167634004783 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1167634004784 putative NAD(P) binding site [chemical binding]; other site 1167634004785 catalytic Zn binding site [ion binding]; other site 1167634004786 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634004787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634004788 substrate binding pocket [chemical binding]; other site 1167634004789 membrane-bound complex binding site; other site 1167634004790 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634004791 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634004792 substrate binding pocket [chemical binding]; other site 1167634004793 membrane-bound complex binding site; other site 1167634004794 hinge residues; other site 1167634004795 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1167634004796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634004797 DNA-binding site [nucleotide binding]; DNA binding site 1167634004798 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1167634004799 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1167634004800 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1167634004801 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1167634004802 substrate binding pocket [chemical binding]; other site 1167634004803 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1167634004804 B12 binding site [chemical binding]; other site 1167634004805 cobalt ligand [ion binding]; other site 1167634004806 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1167634004807 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1167634004808 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634004809 N-terminal plug; other site 1167634004810 ligand-binding site [chemical binding]; other site 1167634004811 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1167634004812 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1167634004813 cobalamin binding residues [chemical binding]; other site 1167634004814 putative BtuC binding residues; other site 1167634004815 dimer interface [polypeptide binding]; other site 1167634004816 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1167634004817 ThiS interaction site; other site 1167634004818 putative active site [active] 1167634004819 tetramer interface [polypeptide binding]; other site 1167634004820 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1167634004821 dimer interface [polypeptide binding]; other site 1167634004822 substrate binding site [chemical binding]; other site 1167634004823 ATP binding site [chemical binding]; other site 1167634004824 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1167634004825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634004826 S-adenosylmethionine binding site [chemical binding]; other site 1167634004827 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1167634004828 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 1167634004829 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1167634004830 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1167634004831 active site 1167634004832 nucleotide binding site [chemical binding]; other site 1167634004833 HIGH motif; other site 1167634004834 KMSKS motif; other site 1167634004835 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1167634004836 dinuclear metal binding motif [ion binding]; other site 1167634004837 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1167634004838 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1167634004839 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1167634004840 Tim44-like domain; Region: Tim44; cl09208 1167634004841 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1167634004842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634004843 S-adenosylmethionine binding site [chemical binding]; other site 1167634004844 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1167634004845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634004846 active site 1167634004847 phosphorylation site [posttranslational modification] 1167634004848 intermolecular recognition site; other site 1167634004849 dimerization interface [polypeptide binding]; other site 1167634004850 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634004851 DNA binding site [nucleotide binding] 1167634004852 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1167634004853 PAS domain; Region: PAS; smart00091 1167634004854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634004855 dimer interface [polypeptide binding]; other site 1167634004856 phosphorylation site [posttranslational modification] 1167634004857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634004858 ATP binding site [chemical binding]; other site 1167634004859 Mg2+ binding site [ion binding]; other site 1167634004860 G-X-G motif; other site 1167634004861 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1167634004862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634004863 active site 1167634004864 phosphorylation site [posttranslational modification] 1167634004865 intermolecular recognition site; other site 1167634004866 dimerization interface [polypeptide binding]; other site 1167634004867 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634004868 DNA binding site [nucleotide binding] 1167634004869 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1167634004870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634004871 dimerization interface [polypeptide binding]; other site 1167634004872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634004873 dimer interface [polypeptide binding]; other site 1167634004874 phosphorylation site [posttranslational modification] 1167634004875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634004876 ATP binding site [chemical binding]; other site 1167634004877 Mg2+ binding site [ion binding]; other site 1167634004878 G-X-G motif; other site 1167634004879 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1167634004880 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1167634004881 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1167634004882 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1167634004883 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1167634004884 Protein of unknown function, DUF; Region: DUF411; cl01142 1167634004885 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1167634004886 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1167634004887 ligand binding site [chemical binding]; other site 1167634004888 NAD binding site [chemical binding]; other site 1167634004889 tetramer interface [polypeptide binding]; other site 1167634004890 catalytic site [active] 1167634004891 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1167634004892 L-serine binding site [chemical binding]; other site 1167634004893 ACT domain interface; other site 1167634004894 HD domain; Region: HD_3; pfam13023 1167634004895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634004896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634004897 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 1167634004898 putative dimerization interface [polypeptide binding]; other site 1167634004899 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1167634004900 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634004901 putative metal binding site [ion binding]; other site 1167634004902 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1167634004903 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1167634004904 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1167634004905 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1167634004906 putative active site [active] 1167634004907 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634004908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634004909 DNA-binding site [nucleotide binding]; DNA binding site 1167634004910 FCD domain; Region: FCD; pfam07729 1167634004911 Predicted membrane protein [Function unknown]; Region: COG2860 1167634004912 UPF0126 domain; Region: UPF0126; pfam03458 1167634004913 UPF0126 domain; Region: UPF0126; pfam03458 1167634004914 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1167634004915 Ligand Binding Site [chemical binding]; other site 1167634004916 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1167634004917 Ligand Binding Site [chemical binding]; other site 1167634004918 muropeptide transporter; Validated; Region: ampG; cl17669 1167634004919 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1167634004920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1167634004921 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1167634004922 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1167634004923 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1167634004924 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634004925 DNA-binding site [nucleotide binding]; DNA binding site 1167634004926 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1167634004927 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1167634004928 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1167634004929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634004930 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1167634004931 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1167634004932 ligand binding site [chemical binding]; other site 1167634004933 NAD binding site [chemical binding]; other site 1167634004934 dimerization interface [polypeptide binding]; other site 1167634004935 catalytic site [active] 1167634004936 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1167634004937 Membrane transport protein; Region: Mem_trans; cl09117 1167634004938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634004939 DNA binding residues [nucleotide binding] 1167634004940 dimerization interface [polypeptide binding]; other site 1167634004941 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1167634004942 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1167634004943 Serine hydrolase; Region: Ser_hydrolase; cl17834 1167634004944 glutamate--cysteine ligase; Provisional; Region: PRK02107 1167634004945 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1167634004946 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1167634004947 active site 1167634004948 Zn binding site [ion binding]; other site 1167634004949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634004950 transcriptional regulator, ArgP family; Region: argP; TIGR03298 1167634004951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634004952 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634004953 dimerization interface [polypeptide binding]; other site 1167634004954 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1167634004955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634004956 DNA-binding site [nucleotide binding]; DNA binding site 1167634004957 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1167634004958 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1167634004959 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1167634004960 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1167634004961 putative active site [active] 1167634004962 catalytic triad [active] 1167634004963 putative dimer interface [polypeptide binding]; other site 1167634004964 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634004965 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634004966 Walker A/P-loop; other site 1167634004967 ATP binding site [chemical binding]; other site 1167634004968 Q-loop/lid; other site 1167634004969 ABC transporter signature motif; other site 1167634004970 Walker B; other site 1167634004971 D-loop; other site 1167634004972 H-loop/switch region; other site 1167634004973 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634004974 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634004975 Walker A/P-loop; other site 1167634004976 ATP binding site [chemical binding]; other site 1167634004977 Q-loop/lid; other site 1167634004978 ABC transporter signature motif; other site 1167634004979 Walker B; other site 1167634004980 D-loop; other site 1167634004981 H-loop/switch region; other site 1167634004982 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634004983 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634004984 TM-ABC transporter signature motif; other site 1167634004985 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634004986 TM-ABC transporter signature motif; other site 1167634004987 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634004988 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 1167634004989 putative ligand binding site [chemical binding]; other site 1167634004990 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1167634004991 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1167634004992 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1167634004993 Cupin domain; Region: Cupin_2; pfam07883 1167634004994 Cupin domain; Region: Cupin_2; pfam07883 1167634004995 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1167634004996 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1167634004997 trimer interface [polypeptide binding]; other site 1167634004998 eyelet of channel; other site 1167634004999 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1167634005000 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1167634005001 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634005002 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1167634005003 Cupin domain; Region: Cupin_2; pfam07883 1167634005004 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634005005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634005006 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634005007 putative effector binding pocket; other site 1167634005008 dimerization interface [polypeptide binding]; other site 1167634005009 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1167634005010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634005011 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1167634005012 NAD(P) binding site [chemical binding]; other site 1167634005013 active site 1167634005014 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1167634005015 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1167634005016 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1167634005017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634005018 putative substrate translocation pore; other site 1167634005019 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1167634005020 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1167634005021 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1167634005022 catalytic residues [active] 1167634005023 catalytic nucleophile [active] 1167634005024 Presynaptic Site I dimer interface [polypeptide binding]; other site 1167634005025 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1167634005026 Synaptic Flat tetramer interface [polypeptide binding]; other site 1167634005027 Synaptic Site I dimer interface [polypeptide binding]; other site 1167634005028 DNA binding site [nucleotide binding] 1167634005029 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1167634005030 DNA-binding interface [nucleotide binding]; DNA binding site 1167634005031 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1167634005032 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1167634005033 Antirestriction protein (ArdA); Region: ArdA; pfam07275 1167634005034 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1167634005035 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1167634005036 Walker A motif; other site 1167634005037 ATP binding site [chemical binding]; other site 1167634005038 Walker B motif; other site 1167634005039 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1167634005040 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1167634005041 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634005042 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634005043 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634005044 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634005045 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634005046 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634005047 active site 1167634005048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634005049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634005050 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1167634005051 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1167634005052 FMN binding site [chemical binding]; other site 1167634005053 substrate binding site [chemical binding]; other site 1167634005054 putative catalytic residue [active] 1167634005055 enoyl-CoA hydratase; Provisional; Region: PRK06688 1167634005056 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634005057 substrate binding site [chemical binding]; other site 1167634005058 oxyanion hole (OAH) forming residues; other site 1167634005059 trimer interface [polypeptide binding]; other site 1167634005060 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634005061 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1167634005062 substrate binding site [chemical binding]; other site 1167634005063 oxyanion hole (OAH) forming residues; other site 1167634005064 trimer interface [polypeptide binding]; other site 1167634005065 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1167634005066 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1167634005067 putative substrate binding site [chemical binding]; other site 1167634005068 putative ATP binding site [chemical binding]; other site 1167634005069 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1167634005070 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1167634005071 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634005072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634005073 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634005074 dimerization interface [polypeptide binding]; other site 1167634005075 hypothetical protein; Provisional; Region: PRK07079 1167634005076 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 1167634005077 metal binding site [ion binding]; metal-binding site 1167634005078 putative dimer interface [polypeptide binding]; other site 1167634005079 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1167634005080 active site 1167634005081 Zn binding site [ion binding]; other site 1167634005082 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1167634005083 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1167634005084 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634005085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634005086 dimer interface [polypeptide binding]; other site 1167634005087 conserved gate region; other site 1167634005088 putative PBP binding loops; other site 1167634005089 ABC-ATPase subunit interface; other site 1167634005090 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1167634005091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634005092 dimer interface [polypeptide binding]; other site 1167634005093 conserved gate region; other site 1167634005094 putative PBP binding loops; other site 1167634005095 ABC-ATPase subunit interface; other site 1167634005096 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1167634005097 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634005098 Walker A/P-loop; other site 1167634005099 ATP binding site [chemical binding]; other site 1167634005100 Q-loop/lid; other site 1167634005101 ABC transporter signature motif; other site 1167634005102 Walker B; other site 1167634005103 D-loop; other site 1167634005104 H-loop/switch region; other site 1167634005105 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1167634005106 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1167634005107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634005108 Walker A/P-loop; other site 1167634005109 ATP binding site [chemical binding]; other site 1167634005110 Q-loop/lid; other site 1167634005111 ABC transporter signature motif; other site 1167634005112 Walker B; other site 1167634005113 D-loop; other site 1167634005114 H-loop/switch region; other site 1167634005115 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1167634005116 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1167634005117 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1167634005118 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 1167634005119 metal binding site [ion binding]; metal-binding site 1167634005120 dimer interface [polypeptide binding]; other site 1167634005121 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1167634005122 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1167634005123 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1167634005124 putative trimer interface [polypeptide binding]; other site 1167634005125 putative CoA binding site [chemical binding]; other site 1167634005126 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1167634005127 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1167634005128 conserved cys residue [active] 1167634005129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634005130 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1167634005131 classical (c) SDRs; Region: SDR_c; cd05233 1167634005132 NAD(P) binding site [chemical binding]; other site 1167634005133 active site 1167634005134 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1167634005135 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1167634005136 putative dimer interface [polypeptide binding]; other site 1167634005137 putative active site [active] 1167634005138 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1167634005139 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1167634005140 tetramer interface [polypeptide binding]; other site 1167634005141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634005142 catalytic residue [active] 1167634005143 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1167634005144 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634005145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634005146 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1167634005147 Part of AAA domain; Region: AAA_19; pfam13245 1167634005148 Family description; Region: UvrD_C_2; pfam13538 1167634005149 primosome assembly protein PriA; Validated; Region: PRK05580 1167634005150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1167634005151 ATP binding site [chemical binding]; other site 1167634005152 putative Mg++ binding site [ion binding]; other site 1167634005153 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1167634005154 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1167634005155 substrate binding site [chemical binding]; other site 1167634005156 active site 1167634005157 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1167634005158 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1167634005159 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1167634005160 gamma subunit interface [polypeptide binding]; other site 1167634005161 epsilon subunit interface [polypeptide binding]; other site 1167634005162 LBP interface [polypeptide binding]; other site 1167634005163 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1167634005164 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1167634005165 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1167634005166 alpha subunit interaction interface [polypeptide binding]; other site 1167634005167 Walker A motif; other site 1167634005168 ATP binding site [chemical binding]; other site 1167634005169 Walker B motif; other site 1167634005170 inhibitor binding site; inhibition site 1167634005171 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1167634005172 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1167634005173 core domain interface [polypeptide binding]; other site 1167634005174 delta subunit interface [polypeptide binding]; other site 1167634005175 epsilon subunit interface [polypeptide binding]; other site 1167634005176 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1167634005177 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1167634005178 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1167634005179 beta subunit interaction interface [polypeptide binding]; other site 1167634005180 Walker A motif; other site 1167634005181 ATP binding site [chemical binding]; other site 1167634005182 Walker B motif; other site 1167634005183 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1167634005184 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1167634005185 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1167634005186 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1167634005187 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1167634005188 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1167634005189 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1167634005190 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1167634005191 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1167634005192 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1167634005193 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1167634005194 enoyl-CoA hydratase; Provisional; Region: PRK05862 1167634005195 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634005196 substrate binding site [chemical binding]; other site 1167634005197 oxyanion hole (OAH) forming residues; other site 1167634005198 trimer interface [polypeptide binding]; other site 1167634005199 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1167634005200 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1167634005201 PDZ domain; Region: PDZ_2; pfam13180 1167634005202 protein binding site [polypeptide binding]; other site 1167634005203 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634005204 Coenzyme A transferase; Region: CoA_trans; cl17247 1167634005205 Coenzyme A transferase; Region: CoA_trans; cl17247 1167634005206 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634005207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634005208 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1167634005209 dimerization interface [polypeptide binding]; other site 1167634005210 substrate binding pocket [chemical binding]; other site 1167634005211 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1167634005212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634005213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634005214 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1167634005215 dimerization interface [polypeptide binding]; other site 1167634005216 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1167634005217 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1167634005218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1167634005219 Dihydroneopterin aldolase; Region: FolB; pfam02152 1167634005220 active site 1167634005221 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1167634005222 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1167634005223 Ligand Binding Site [chemical binding]; other site 1167634005224 TIGR00269 family protein; Region: TIGR00269 1167634005225 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1167634005226 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1167634005227 dimerization interface [polypeptide binding]; other site 1167634005228 NAD binding site [chemical binding]; other site 1167634005229 ligand binding site [chemical binding]; other site 1167634005230 catalytic site [active] 1167634005231 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1167634005232 dimerization domain [polypeptide binding]; other site 1167634005233 dimer interface [polypeptide binding]; other site 1167634005234 catalytic residues [active] 1167634005235 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 1167634005236 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1167634005237 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1167634005238 MltA specific insert domain; Region: MltA; smart00925 1167634005239 3D domain; Region: 3D; pfam06725 1167634005240 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1167634005241 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1167634005242 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1167634005243 substrate binding site [chemical binding]; other site 1167634005244 hexamer interface [polypeptide binding]; other site 1167634005245 metal binding site [ion binding]; metal-binding site 1167634005246 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1167634005247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634005248 motif II; other site 1167634005249 anthranilate synthase component I; Provisional; Region: PRK13565 1167634005250 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1167634005251 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1167634005252 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1167634005253 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1167634005254 glutamine binding [chemical binding]; other site 1167634005255 catalytic triad [active] 1167634005256 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1167634005257 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1167634005258 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1167634005259 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1167634005260 active site 1167634005261 ribulose/triose binding site [chemical binding]; other site 1167634005262 phosphate binding site [ion binding]; other site 1167634005263 substrate (anthranilate) binding pocket [chemical binding]; other site 1167634005264 product (indole) binding pocket [chemical binding]; other site 1167634005265 GAF domain; Region: GAF; pfam01590 1167634005266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634005267 Walker A motif; other site 1167634005268 ATP binding site [chemical binding]; other site 1167634005269 Walker B motif; other site 1167634005270 arginine finger; other site 1167634005271 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1167634005272 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1167634005273 NAD(P) binding site [chemical binding]; other site 1167634005274 catalytic residues [active] 1167634005275 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1167634005276 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1167634005277 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1167634005278 putative catalytic residue [active] 1167634005279 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 1167634005280 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1167634005281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634005282 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634005283 dimerization interface [polypeptide binding]; other site 1167634005284 Sulfatase; Region: Sulfatase; cl17466 1167634005285 selenophosphate synthetase; Provisional; Region: PRK00943 1167634005286 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1167634005287 dimerization interface [polypeptide binding]; other site 1167634005288 putative ATP binding site [chemical binding]; other site 1167634005289 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1167634005290 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1167634005291 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1167634005292 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1167634005293 catalytic residues [active] 1167634005294 putative glycosyl transferase; Provisional; Region: PRK10073 1167634005295 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1167634005296 active site 1167634005297 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1167634005298 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1167634005299 G1 box; other site 1167634005300 putative GEF interaction site [polypeptide binding]; other site 1167634005301 GTP/Mg2+ binding site [chemical binding]; other site 1167634005302 Switch I region; other site 1167634005303 G2 box; other site 1167634005304 G3 box; other site 1167634005305 Switch II region; other site 1167634005306 G4 box; other site 1167634005307 G5 box; other site 1167634005308 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1167634005309 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1167634005310 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1167634005311 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1167634005312 selenocysteine synthase; Provisional; Region: PRK04311 1167634005313 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1167634005314 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634005315 catalytic residue [active] 1167634005316 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1167634005317 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1167634005318 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1167634005319 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1167634005320 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1167634005321 4Fe-4S binding domain; Region: Fer4; cl02805 1167634005322 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1167634005323 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1167634005324 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1167634005325 [4Fe-4S] binding site [ion binding]; other site 1167634005326 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1167634005327 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1167634005328 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1167634005329 molybdopterin cofactor binding site; other site 1167634005330 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1167634005331 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1167634005332 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1167634005333 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1167634005334 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1167634005335 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1167634005336 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1167634005337 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1167634005338 NodB motif; other site 1167634005339 active site 1167634005340 catalytic site [active] 1167634005341 metal binding site [ion binding]; metal-binding site 1167634005342 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1167634005343 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1167634005344 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1167634005345 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1167634005346 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1167634005347 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1167634005348 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634005349 Walker A/P-loop; other site 1167634005350 ATP binding site [chemical binding]; other site 1167634005351 Q-loop/lid; other site 1167634005352 ABC transporter signature motif; other site 1167634005353 Walker B; other site 1167634005354 D-loop; other site 1167634005355 H-loop/switch region; other site 1167634005356 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1167634005357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634005358 dimer interface [polypeptide binding]; other site 1167634005359 conserved gate region; other site 1167634005360 ABC-ATPase subunit interface; other site 1167634005361 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1167634005362 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1167634005363 Walker A/P-loop; other site 1167634005364 ATP binding site [chemical binding]; other site 1167634005365 Q-loop/lid; other site 1167634005366 ABC transporter signature motif; other site 1167634005367 Walker B; other site 1167634005368 D-loop; other site 1167634005369 H-loop/switch region; other site 1167634005370 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1167634005371 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634005372 active site 1167634005373 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634005374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634005375 putative PBP binding loops; other site 1167634005376 ABC-ATPase subunit interface; other site 1167634005377 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1167634005378 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1167634005379 active site 1167634005380 dimer interface [polypeptide binding]; other site 1167634005381 non-prolyl cis peptide bond; other site 1167634005382 insertion regions; other site 1167634005383 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1167634005384 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634005385 substrate binding pocket [chemical binding]; other site 1167634005386 membrane-bound complex binding site; other site 1167634005387 hinge residues; other site 1167634005388 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 1167634005389 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1167634005390 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1167634005391 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1167634005392 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1167634005393 MULE transposase domain; Region: MULE; pfam10551 1167634005394 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1167634005395 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1167634005396 non-prolyl cis peptide bond; other site 1167634005397 active site 1167634005398 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1167634005399 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634005400 active site 1167634005401 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1167634005402 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634005403 active site 1167634005404 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1167634005405 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1167634005406 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634005407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634005408 dimer interface [polypeptide binding]; other site 1167634005409 conserved gate region; other site 1167634005410 putative PBP binding loops; other site 1167634005411 ABC-ATPase subunit interface; other site 1167634005412 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1167634005413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634005414 dimer interface [polypeptide binding]; other site 1167634005415 conserved gate region; other site 1167634005416 putative PBP binding loops; other site 1167634005417 ABC-ATPase subunit interface; other site 1167634005418 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1167634005419 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634005420 Walker A/P-loop; other site 1167634005421 ATP binding site [chemical binding]; other site 1167634005422 Q-loop/lid; other site 1167634005423 ABC transporter signature motif; other site 1167634005424 Walker B; other site 1167634005425 D-loop; other site 1167634005426 H-loop/switch region; other site 1167634005427 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634005428 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634005429 Walker A/P-loop; other site 1167634005430 ATP binding site [chemical binding]; other site 1167634005431 Q-loop/lid; other site 1167634005432 ABC transporter signature motif; other site 1167634005433 Walker B; other site 1167634005434 D-loop; other site 1167634005435 H-loop/switch region; other site 1167634005436 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634005437 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1167634005438 Ligand Binding Site [chemical binding]; other site 1167634005439 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1167634005440 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1167634005441 catalytic loop [active] 1167634005442 iron binding site [ion binding]; other site 1167634005443 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1167634005444 FAD binding pocket [chemical binding]; other site 1167634005445 FAD binding motif [chemical binding]; other site 1167634005446 phosphate binding motif [ion binding]; other site 1167634005447 beta-alpha-beta structure motif; other site 1167634005448 NAD binding pocket [chemical binding]; other site 1167634005449 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1167634005450 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1167634005451 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1167634005452 NAD(P) binding site [chemical binding]; other site 1167634005453 catalytic residues [active] 1167634005454 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634005455 DNA-binding site [nucleotide binding]; DNA binding site 1167634005456 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1167634005457 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1167634005458 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1167634005459 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1167634005460 catalytic loop [active] 1167634005461 iron binding site [ion binding]; other site 1167634005462 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1167634005463 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1167634005464 catalytic loop [active] 1167634005465 iron binding site [ion binding]; other site 1167634005466 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1167634005467 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1167634005468 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1167634005469 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1167634005470 Moco binding site; other site 1167634005471 metal coordination site [ion binding]; other site 1167634005472 Transmembrane secretion effector; Region: MFS_3; pfam05977 1167634005473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634005474 putative substrate translocation pore; other site 1167634005475 Site-specific recombinase; Region: SpecificRecomb; pfam10136 1167634005476 Spore Coat Protein U domain; Region: SCPU; pfam05229 1167634005477 Spore Coat Protein U domain; Region: SCPU; pfam05229 1167634005478 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1167634005479 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1167634005480 PapC C-terminal domain; Region: PapC_C; pfam13953 1167634005481 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1167634005482 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1167634005483 Spore Coat Protein U domain; Region: SCPU; smart00972 1167634005484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634005485 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1167634005486 putative substrate translocation pore; other site 1167634005487 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1167634005488 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634005489 dimerization interface [polypeptide binding]; other site 1167634005490 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634005491 dimer interface [polypeptide binding]; other site 1167634005492 putative CheW interface [polypeptide binding]; other site 1167634005493 imidazolonepropionase; Validated; Region: PRK09356 1167634005494 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1167634005495 active site 1167634005496 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1167634005497 active sites [active] 1167634005498 tetramer interface [polypeptide binding]; other site 1167634005499 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1167634005500 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1167634005501 urocanate hydratase; Provisional; Region: PRK05414 1167634005502 HutD; Region: HutD; pfam05962 1167634005503 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1167634005504 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634005505 DNA-binding site [nucleotide binding]; DNA binding site 1167634005506 UTRA domain; Region: UTRA; pfam07702 1167634005507 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1167634005508 putative metal binding site [ion binding]; other site 1167634005509 putative homodimer interface [polypeptide binding]; other site 1167634005510 putative homotetramer interface [polypeptide binding]; other site 1167634005511 putative homodimer-homodimer interface [polypeptide binding]; other site 1167634005512 putative allosteric switch controlling residues; other site 1167634005513 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1167634005514 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1167634005515 substrate binding site [chemical binding]; other site 1167634005516 catalytic Zn binding site [ion binding]; other site 1167634005517 NAD binding site [chemical binding]; other site 1167634005518 structural Zn binding site [ion binding]; other site 1167634005519 dimer interface [polypeptide binding]; other site 1167634005520 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 1167634005521 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 1167634005522 active site 1167634005523 metal binding site [ion binding]; metal-binding site 1167634005524 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1167634005525 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1167634005526 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1167634005527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634005528 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1167634005529 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1167634005530 HAMP domain; Region: HAMP; pfam00672 1167634005531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634005532 dimer interface [polypeptide binding]; other site 1167634005533 phosphorylation site [posttranslational modification] 1167634005534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634005535 ATP binding site [chemical binding]; other site 1167634005536 Mg2+ binding site [ion binding]; other site 1167634005537 G-X-G motif; other site 1167634005538 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1167634005539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634005540 active site 1167634005541 phosphorylation site [posttranslational modification] 1167634005542 intermolecular recognition site; other site 1167634005543 dimerization interface [polypeptide binding]; other site 1167634005544 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634005545 DNA binding site [nucleotide binding] 1167634005546 Outer membrane efflux protein; Region: OEP; pfam02321 1167634005547 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1167634005548 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634005549 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1167634005550 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1167634005551 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1167634005552 Ligand binding site; other site 1167634005553 Putative Catalytic site; other site 1167634005554 DXD motif; other site 1167634005555 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1167634005556 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1167634005557 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1167634005558 agmatinase; Region: agmatinase; TIGR01230 1167634005559 oligomer interface [polypeptide binding]; other site 1167634005560 putative active site [active] 1167634005561 Mn binding site [ion binding]; other site 1167634005562 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1167634005563 Na binding site [ion binding]; other site 1167634005564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634005565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634005566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634005567 dimerization interface [polypeptide binding]; other site 1167634005568 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1167634005569 oligomerization interface [polypeptide binding]; other site 1167634005570 active site 1167634005571 metal binding site [ion binding]; metal-binding site 1167634005572 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1167634005573 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1167634005574 G1 box; other site 1167634005575 Walker A motif; other site 1167634005576 GTP/Mg2+ binding site [chemical binding]; other site 1167634005577 G2 box; other site 1167634005578 G3 box; other site 1167634005579 Switch II region; other site 1167634005580 G4 box; other site 1167634005581 G5 box; other site 1167634005582 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1167634005583 ornithine cyclodeaminase; Validated; Region: PRK07589 1167634005584 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1167634005585 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 1167634005586 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1167634005587 tetramer interface [polypeptide binding]; other site 1167634005588 active site 1167634005589 catalytic triad [active] 1167634005590 dimer interface [polypeptide binding]; other site 1167634005591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634005592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634005593 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634005594 putative effector binding pocket; other site 1167634005595 dimerization interface [polypeptide binding]; other site 1167634005596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634005597 quinolinate synthetase; Provisional; Region: PRK09375 1167634005598 L-aspartate oxidase; Provisional; Region: PRK09077 1167634005599 L-aspartate oxidase; Provisional; Region: PRK06175 1167634005600 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1167634005601 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 1167634005602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 1167634005603 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 1167634005604 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 1167634005605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1167634005606 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1167634005607 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1167634005608 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1167634005609 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1167634005610 Walker A/P-loop; other site 1167634005611 ATP binding site [chemical binding]; other site 1167634005612 Q-loop/lid; other site 1167634005613 ABC transporter signature motif; other site 1167634005614 Walker B; other site 1167634005615 D-loop; other site 1167634005616 H-loop/switch region; other site 1167634005617 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1167634005618 ABC-ATPase subunit interface; other site 1167634005619 dimer interface [polypeptide binding]; other site 1167634005620 putative PBP binding regions; other site 1167634005621 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1167634005622 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1167634005623 dimer interface [polypeptide binding]; other site 1167634005624 putative PBP binding regions; other site 1167634005625 ABC-ATPase subunit interface; other site 1167634005626 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1167634005627 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1167634005628 intersubunit interface [polypeptide binding]; other site 1167634005629 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1167634005630 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634005631 N-terminal plug; other site 1167634005632 ligand-binding site [chemical binding]; other site 1167634005633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634005634 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634005635 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634005636 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634005637 nucleotide binding region [chemical binding]; other site 1167634005638 ATP-binding site [chemical binding]; other site 1167634005639 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 1167634005640 homodimer interface [polypeptide binding]; other site 1167634005641 putative active site [active] 1167634005642 catalytic site [active] 1167634005643 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1167634005644 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 1167634005645 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1167634005646 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1167634005647 Part of AAA domain; Region: AAA_19; pfam13245 1167634005648 Family description; Region: UvrD_C_2; pfam13538 1167634005649 WYL domain; Region: WYL; pfam13280 1167634005650 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1167634005651 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1167634005652 glutaminase active site [active] 1167634005653 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1167634005654 dimer interface [polypeptide binding]; other site 1167634005655 active site 1167634005656 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1167634005657 dimer interface [polypeptide binding]; other site 1167634005658 active site 1167634005659 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634005660 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1167634005661 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634005662 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634005663 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1167634005664 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1167634005665 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1167634005666 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1167634005667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634005668 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634005669 putative substrate translocation pore; other site 1167634005670 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1167634005671 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1167634005672 Substrate binding site; other site 1167634005673 Mg++ binding site; other site 1167634005674 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1167634005675 active site 1167634005676 substrate binding site [chemical binding]; other site 1167634005677 CoA binding site [chemical binding]; other site 1167634005678 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 1167634005679 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1167634005680 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1167634005681 Cu(I) binding site [ion binding]; other site 1167634005682 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1167634005683 UbiA prenyltransferase family; Region: UbiA; pfam01040 1167634005684 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1167634005685 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1167634005686 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1167634005687 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1167634005688 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1167634005689 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1167634005690 Subunit III/VIIa interface [polypeptide binding]; other site 1167634005691 Phospholipid binding site [chemical binding]; other site 1167634005692 Subunit I/III interface [polypeptide binding]; other site 1167634005693 Subunit III/VIb interface [polypeptide binding]; other site 1167634005694 Subunit III/VIa interface; other site 1167634005695 Subunit III/Vb interface [polypeptide binding]; other site 1167634005696 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1167634005697 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1167634005698 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1167634005699 Subunit I/III interface [polypeptide binding]; other site 1167634005700 D-pathway; other site 1167634005701 Subunit I/VIIc interface [polypeptide binding]; other site 1167634005702 Subunit I/IV interface [polypeptide binding]; other site 1167634005703 Subunit I/II interface [polypeptide binding]; other site 1167634005704 Low-spin heme (heme a) binding site [chemical binding]; other site 1167634005705 Subunit I/VIIa interface [polypeptide binding]; other site 1167634005706 Subunit I/VIa interface [polypeptide binding]; other site 1167634005707 Dimer interface; other site 1167634005708 Putative water exit pathway; other site 1167634005709 Binuclear center (heme a3/CuB) [ion binding]; other site 1167634005710 K-pathway; other site 1167634005711 Subunit I/Vb interface [polypeptide binding]; other site 1167634005712 Putative proton exit pathway; other site 1167634005713 Subunit I/VIb interface; other site 1167634005714 Subunit I/VIc interface [polypeptide binding]; other site 1167634005715 Electron transfer pathway; other site 1167634005716 Subunit I/VIIIb interface [polypeptide binding]; other site 1167634005717 Subunit I/VIIb interface [polypeptide binding]; other site 1167634005718 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 1167634005719 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1167634005720 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1167634005721 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1167634005722 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1167634005723 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1167634005724 nudix motif; other site 1167634005725 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1167634005726 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1167634005727 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1167634005728 ligand binding site [chemical binding]; other site 1167634005729 flexible hinge region; other site 1167634005730 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1167634005731 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1167634005732 active site 1167634005733 metal binding site [ion binding]; metal-binding site 1167634005734 hexamer interface [polypeptide binding]; other site 1167634005735 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1167634005736 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634005737 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634005738 DNA binding residues [nucleotide binding] 1167634005739 S-formylglutathione hydrolase; Region: PLN02442 1167634005740 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1167634005741 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1167634005742 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1167634005743 active site 1167634005744 dimer interface [polypeptide binding]; other site 1167634005745 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1167634005746 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1167634005747 active site 1167634005748 FMN binding site [chemical binding]; other site 1167634005749 substrate binding site [chemical binding]; other site 1167634005750 3Fe-4S cluster binding site [ion binding]; other site 1167634005751 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1167634005752 domain interface; other site 1167634005753 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1167634005754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1167634005755 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1167634005756 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1167634005757 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1167634005758 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 1167634005759 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1167634005760 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1167634005761 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1167634005762 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1167634005763 carboxyltransferase (CT) interaction site; other site 1167634005764 biotinylation site [posttranslational modification]; other site 1167634005765 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 1167634005766 putative active site [active] 1167634005767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634005768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634005769 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1167634005770 putative substrate binding pocket [chemical binding]; other site 1167634005771 dimerization interface [polypeptide binding]; other site 1167634005772 OmpW family; Region: OmpW; cl17427 1167634005773 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634005774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634005775 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1167634005776 putative dimerization interface [polypeptide binding]; other site 1167634005777 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1167634005778 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634005779 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1167634005780 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1167634005781 FMN binding site [chemical binding]; other site 1167634005782 substrate binding site [chemical binding]; other site 1167634005783 putative catalytic residue [active] 1167634005784 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1167634005785 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1167634005786 Walker A/P-loop; other site 1167634005787 ATP binding site [chemical binding]; other site 1167634005788 Q-loop/lid; other site 1167634005789 ABC transporter signature motif; other site 1167634005790 Walker B; other site 1167634005791 D-loop; other site 1167634005792 H-loop/switch region; other site 1167634005793 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1167634005794 Permease; Region: Permease; pfam02405 1167634005795 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1167634005796 mce related protein; Region: MCE; pfam02470 1167634005797 VacJ like lipoprotein; Region: VacJ; cl01073 1167634005798 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1167634005799 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1167634005800 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1167634005801 Walker A/P-loop; other site 1167634005802 ATP binding site [chemical binding]; other site 1167634005803 Q-loop/lid; other site 1167634005804 ABC transporter signature motif; other site 1167634005805 Walker B; other site 1167634005806 D-loop; other site 1167634005807 H-loop/switch region; other site 1167634005808 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1167634005809 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1167634005810 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1167634005811 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1167634005812 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1167634005813 hinge; other site 1167634005814 active site 1167634005815 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1167634005816 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1167634005817 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1167634005818 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1167634005819 NAD binding site [chemical binding]; other site 1167634005820 dimerization interface [polypeptide binding]; other site 1167634005821 product binding site; other site 1167634005822 substrate binding site [chemical binding]; other site 1167634005823 zinc binding site [ion binding]; other site 1167634005824 catalytic residues [active] 1167634005825 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 1167634005826 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634005827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634005828 homodimer interface [polypeptide binding]; other site 1167634005829 catalytic residue [active] 1167634005830 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1167634005831 putative active site pocket [active] 1167634005832 4-fold oligomerization interface [polypeptide binding]; other site 1167634005833 metal binding residues [ion binding]; metal-binding site 1167634005834 3-fold/trimer interface [polypeptide binding]; other site 1167634005835 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1167634005836 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1167634005837 putative active site [active] 1167634005838 oxyanion strand; other site 1167634005839 catalytic triad [active] 1167634005840 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1167634005841 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1167634005842 catalytic residues [active] 1167634005843 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1167634005844 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1167634005845 substrate binding site [chemical binding]; other site 1167634005846 glutamase interaction surface [polypeptide binding]; other site 1167634005847 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1167634005848 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1167634005849 metal binding site [ion binding]; metal-binding site 1167634005850 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1167634005851 nucleotide binding site/active site [active] 1167634005852 HIT family signature motif; other site 1167634005853 catalytic residue [active] 1167634005854 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 1167634005855 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1167634005856 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1167634005857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634005858 non-specific DNA binding site [nucleotide binding]; other site 1167634005859 salt bridge; other site 1167634005860 sequence-specific DNA binding site [nucleotide binding]; other site 1167634005861 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1167634005862 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1167634005863 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1167634005864 protein binding site [polypeptide binding]; other site 1167634005865 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1167634005866 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1167634005867 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1167634005868 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1167634005869 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1167634005870 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1167634005871 [2Fe-2S] cluster binding site [ion binding]; other site 1167634005872 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1167634005873 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1167634005874 Qi binding site; other site 1167634005875 intrachain domain interface; other site 1167634005876 interchain domain interface [polypeptide binding]; other site 1167634005877 heme bH binding site [chemical binding]; other site 1167634005878 heme bL binding site [chemical binding]; other site 1167634005879 Qo binding site; other site 1167634005880 interchain domain interface [polypeptide binding]; other site 1167634005881 intrachain domain interface; other site 1167634005882 Qi binding site; other site 1167634005883 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 1167634005884 Qo binding site; other site 1167634005885 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1167634005886 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1167634005887 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1167634005888 C-terminal domain interface [polypeptide binding]; other site 1167634005889 putative GSH binding site (G-site) [chemical binding]; other site 1167634005890 dimer interface [polypeptide binding]; other site 1167634005891 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1167634005892 dimer interface [polypeptide binding]; other site 1167634005893 N-terminal domain interface [polypeptide binding]; other site 1167634005894 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1167634005895 GntP family permease; Region: GntP_permease; pfam02447 1167634005896 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1167634005897 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1167634005898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634005899 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1167634005900 dimerization interface [polypeptide binding]; other site 1167634005901 substrate binding pocket [chemical binding]; other site 1167634005902 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1167634005903 homotrimer interaction site [polypeptide binding]; other site 1167634005904 putative active site [active] 1167634005905 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1167634005906 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1167634005907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634005908 catalytic residue [active] 1167634005909 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1167634005910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634005911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634005912 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 1167634005913 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 1167634005914 G1 box; other site 1167634005915 GTP/Mg2+ binding site [chemical binding]; other site 1167634005916 G2 box; other site 1167634005917 Switch I region; other site 1167634005918 G3 box; other site 1167634005919 Switch II region; other site 1167634005920 G4 box; other site 1167634005921 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 1167634005922 G5 box; other site 1167634005923 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1167634005924 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1167634005925 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634005926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634005927 dimer interface [polypeptide binding]; other site 1167634005928 conserved gate region; other site 1167634005929 putative PBP binding loops; other site 1167634005930 ABC-ATPase subunit interface; other site 1167634005931 dipeptide transporter; Provisional; Region: PRK10913 1167634005932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634005933 dimer interface [polypeptide binding]; other site 1167634005934 conserved gate region; other site 1167634005935 putative PBP binding loops; other site 1167634005936 ABC-ATPase subunit interface; other site 1167634005937 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1167634005938 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634005939 Walker A/P-loop; other site 1167634005940 ATP binding site [chemical binding]; other site 1167634005941 Q-loop/lid; other site 1167634005942 ABC transporter signature motif; other site 1167634005943 Walker B; other site 1167634005944 D-loop; other site 1167634005945 H-loop/switch region; other site 1167634005946 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1167634005947 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634005948 Walker A/P-loop; other site 1167634005949 ATP binding site [chemical binding]; other site 1167634005950 Q-loop/lid; other site 1167634005951 ABC transporter signature motif; other site 1167634005952 Walker B; other site 1167634005953 D-loop; other site 1167634005954 H-loop/switch region; other site 1167634005955 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634005956 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1167634005957 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634005958 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1167634005959 active site 1167634005960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1167634005961 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1167634005962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1167634005963 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1167634005964 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1167634005965 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1167634005966 ATP binding site [chemical binding]; other site 1167634005967 Mg++ binding site [ion binding]; other site 1167634005968 motif III; other site 1167634005969 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634005970 nucleotide binding region [chemical binding]; other site 1167634005971 ATP-binding site [chemical binding]; other site 1167634005972 LysE type translocator; Region: LysE; cl00565 1167634005973 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1167634005974 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1167634005975 G1 box; other site 1167634005976 putative GEF interaction site [polypeptide binding]; other site 1167634005977 GTP/Mg2+ binding site [chemical binding]; other site 1167634005978 Switch I region; other site 1167634005979 G2 box; other site 1167634005980 G3 box; other site 1167634005981 Switch II region; other site 1167634005982 G4 box; other site 1167634005983 G5 box; other site 1167634005984 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1167634005985 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1167634005986 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1167634005987 heme binding site [chemical binding]; other site 1167634005988 ferroxidase pore; other site 1167634005989 ferroxidase diiron center [ion binding]; other site 1167634005990 EamA-like transporter family; Region: EamA; pfam00892 1167634005991 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1167634005992 EamA-like transporter family; Region: EamA; pfam00892 1167634005993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634005994 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634005995 dimerization interface [polypeptide binding]; other site 1167634005996 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1167634005997 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1167634005998 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1167634005999 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1167634006000 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1167634006001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634006002 2-isopropylmalate synthase; Validated; Region: PRK03739 1167634006003 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1167634006004 active site 1167634006005 catalytic residues [active] 1167634006006 metal binding site [ion binding]; metal-binding site 1167634006007 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1167634006008 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1167634006009 Amidase; Region: Amidase; pfam01425 1167634006010 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1167634006011 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1167634006012 DNA binding site [nucleotide binding] 1167634006013 domain linker motif; other site 1167634006014 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 1167634006015 putative dimerization interface [polypeptide binding]; other site 1167634006016 putative ligand binding site [chemical binding]; other site 1167634006017 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1167634006018 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1167634006019 active site 1167634006020 metal binding site [ion binding]; metal-binding site 1167634006021 hexamer interface [polypeptide binding]; other site 1167634006022 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1167634006023 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1167634006024 Walker A/P-loop; other site 1167634006025 ATP binding site [chemical binding]; other site 1167634006026 Q-loop/lid; other site 1167634006027 ABC transporter signature motif; other site 1167634006028 Walker B; other site 1167634006029 D-loop; other site 1167634006030 H-loop/switch region; other site 1167634006031 TOBE domain; Region: TOBE_2; pfam08402 1167634006032 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1167634006033 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1167634006034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006035 dimer interface [polypeptide binding]; other site 1167634006036 conserved gate region; other site 1167634006037 putative PBP binding loops; other site 1167634006038 ABC-ATPase subunit interface; other site 1167634006039 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1167634006040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006041 dimer interface [polypeptide binding]; other site 1167634006042 conserved gate region; other site 1167634006043 putative PBP binding loops; other site 1167634006044 ABC-ATPase subunit interface; other site 1167634006045 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 1167634006046 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1167634006047 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1167634006048 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1167634006049 active site 1167634006050 HIGH motif; other site 1167634006051 KMSK motif region; other site 1167634006052 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1167634006053 tRNA binding surface [nucleotide binding]; other site 1167634006054 anticodon binding site; other site 1167634006055 Sporulation related domain; Region: SPOR; pfam05036 1167634006056 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1167634006057 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1167634006058 catalytic residues [active] 1167634006059 hinge region; other site 1167634006060 alpha helical domain; other site 1167634006061 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634006062 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1167634006063 putative ligand binding site [chemical binding]; other site 1167634006064 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-1; cd12808 1167634006065 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634006066 catalytic site [active] 1167634006067 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1167634006068 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1167634006069 homodimer interface [polypeptide binding]; other site 1167634006070 substrate-cofactor binding pocket; other site 1167634006071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634006072 catalytic residue [active] 1167634006073 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1167634006074 putative FMN binding site [chemical binding]; other site 1167634006075 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634006076 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1167634006077 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1167634006078 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1167634006079 DNA binding residues [nucleotide binding] 1167634006080 putative dimer interface [polypeptide binding]; other site 1167634006081 hypothetical protein; Provisional; Region: PRK02237 1167634006082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634006083 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1167634006084 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1167634006085 metal binding site [ion binding]; metal-binding site 1167634006086 putative dimer interface [polypeptide binding]; other site 1167634006087 isovaleryl-CoA dehydrogenase; Region: PLN02519 1167634006088 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1167634006089 substrate binding site [chemical binding]; other site 1167634006090 FAD binding site [chemical binding]; other site 1167634006091 catalytic base [active] 1167634006092 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1167634006093 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315 1167634006094 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1167634006095 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1167634006096 dimer interface [polypeptide binding]; other site 1167634006097 active site 1167634006098 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1167634006099 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1167634006100 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1167634006101 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1167634006102 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1167634006103 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1167634006104 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1167634006105 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1167634006106 carboxyltransferase (CT) interaction site; other site 1167634006107 biotinylation site [posttranslational modification]; other site 1167634006108 Helix-turn-helix domain; Region: HTH_18; pfam12833 1167634006109 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1167634006110 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634006111 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634006112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634006113 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1167634006114 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1167634006115 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1167634006116 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1167634006117 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1167634006118 enterobactin exporter EntS; Provisional; Region: PRK10489 1167634006119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634006120 putative substrate translocation pore; other site 1167634006121 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1167634006122 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634006123 Acetyl-CoA acetyltransferase [Lipid metabolism]; Region: PaaJ; COG0183 1167634006124 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1167634006125 active site 1167634006126 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1167634006127 DUF35 OB-fold domain; Region: DUF35; pfam01796 1167634006128 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634006129 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1167634006130 CoA binding domain; Region: CoA_binding_2; pfam13380 1167634006131 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1167634006132 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1167634006133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634006134 short chain dehydrogenase; Provisional; Region: PRK06949 1167634006135 NAD(P) binding site [chemical binding]; other site 1167634006136 active site 1167634006137 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634006138 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634006139 active site 1167634006140 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1167634006141 Phosphotransferase enzyme family; Region: APH; pfam01636 1167634006142 putative active site [active] 1167634006143 putative substrate binding site [chemical binding]; other site 1167634006144 ATP binding site [chemical binding]; other site 1167634006145 acyl-CoA synthetase; Validated; Region: PRK08162 1167634006146 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1167634006147 acyl-activating enzyme (AAE) consensus motif; other site 1167634006148 putative active site [active] 1167634006149 AMP binding site [chemical binding]; other site 1167634006150 putative CoA binding site [chemical binding]; other site 1167634006151 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1167634006152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634006153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634006154 DNA binding residues [nucleotide binding] 1167634006155 FecR protein; Region: FecR; pfam04773 1167634006156 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634006157 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634006158 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634006159 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634006160 N-terminal plug; other site 1167634006161 ligand-binding site [chemical binding]; other site 1167634006162 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1167634006163 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1167634006164 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634006165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634006166 DNA-binding site [nucleotide binding]; DNA binding site 1167634006167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634006168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634006169 homodimer interface [polypeptide binding]; other site 1167634006170 catalytic residue [active] 1167634006171 Isochorismatase family; Region: Isochorismatase; pfam00857 1167634006172 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1167634006173 catalytic triad [active] 1167634006174 conserved cis-peptide bond; other site 1167634006175 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1167634006176 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634006177 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1167634006178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634006179 non-specific DNA binding site [nucleotide binding]; other site 1167634006180 salt bridge; other site 1167634006181 sequence-specific DNA binding site [nucleotide binding]; other site 1167634006182 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1167634006183 integral membrane protein; Region: integ_memb_HG; TIGR03954 1167634006184 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1167634006185 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1167634006186 conserved cys residue [active] 1167634006187 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 1167634006188 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1167634006189 inhibitor-cofactor binding pocket; inhibition site 1167634006190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634006191 catalytic residue [active] 1167634006192 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634006193 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634006194 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634006195 substrate binding pocket [chemical binding]; other site 1167634006196 membrane-bound complex binding site; other site 1167634006197 hinge residues; other site 1167634006198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006199 dimer interface [polypeptide binding]; other site 1167634006200 conserved gate region; other site 1167634006201 putative PBP binding loops; other site 1167634006202 ABC-ATPase subunit interface; other site 1167634006203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006204 dimer interface [polypeptide binding]; other site 1167634006205 conserved gate region; other site 1167634006206 putative PBP binding loops; other site 1167634006207 ABC-ATPase subunit interface; other site 1167634006208 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634006209 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634006210 Walker A/P-loop; other site 1167634006211 ATP binding site [chemical binding]; other site 1167634006212 Q-loop/lid; other site 1167634006213 ABC transporter signature motif; other site 1167634006214 Walker B; other site 1167634006215 D-loop; other site 1167634006216 H-loop/switch region; other site 1167634006217 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 1167634006218 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1167634006219 dimer interface [polypeptide binding]; other site 1167634006220 active site 1167634006221 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1167634006222 substrate binding site [chemical binding]; other site 1167634006223 catalytic residue [active] 1167634006224 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1167634006225 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1167634006226 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1167634006227 DctM-like transporters; Region: DctM; pfam06808 1167634006228 Protein of unknown function (DUF494); Region: DUF494; pfam04361 1167634006229 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1167634006230 active site 1167634006231 HIGH motif; other site 1167634006232 nucleotide binding site [chemical binding]; other site 1167634006233 active site 1167634006234 KMSKS motif; other site 1167634006235 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 1167634006236 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 1167634006237 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1167634006238 DNA topoisomerase III; Validated; Region: PRK08173 1167634006239 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1167634006240 active site 1167634006241 putative interdomain interaction site [polypeptide binding]; other site 1167634006242 putative metal-binding site [ion binding]; other site 1167634006243 putative nucleotide binding site [chemical binding]; other site 1167634006244 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1167634006245 domain I; other site 1167634006246 DNA binding groove [nucleotide binding] 1167634006247 phosphate binding site [ion binding]; other site 1167634006248 domain II; other site 1167634006249 domain III; other site 1167634006250 nucleotide binding site [chemical binding]; other site 1167634006251 catalytic site [active] 1167634006252 domain IV; other site 1167634006253 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1167634006254 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1167634006255 NMT1/THI5 like; Region: NMT1; pfam09084 1167634006256 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1167634006257 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1167634006258 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634006259 Walker A/P-loop; other site 1167634006260 ATP binding site [chemical binding]; other site 1167634006261 Q-loop/lid; other site 1167634006262 ABC transporter signature motif; other site 1167634006263 Walker B; other site 1167634006264 D-loop; other site 1167634006265 H-loop/switch region; other site 1167634006266 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634006267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006268 dimer interface [polypeptide binding]; other site 1167634006269 conserved gate region; other site 1167634006270 putative PBP binding loops; other site 1167634006271 ABC-ATPase subunit interface; other site 1167634006272 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 1167634006273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634006274 NAD(P) binding site [chemical binding]; other site 1167634006275 active site 1167634006276 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 1167634006277 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1167634006278 PYR/PP interface [polypeptide binding]; other site 1167634006279 dimer interface [polypeptide binding]; other site 1167634006280 TPP binding site [chemical binding]; other site 1167634006281 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1167634006282 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1167634006283 TPP-binding site [chemical binding]; other site 1167634006284 dimer interface [polypeptide binding]; other site 1167634006285 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634006286 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1167634006287 putative DNA binding site [nucleotide binding]; other site 1167634006288 putative Zn2+ binding site [ion binding]; other site 1167634006289 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634006290 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1167634006291 Proteins containing SET domain [General function prediction only]; Region: COG2940 1167634006292 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 1167634006293 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 1167634006294 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1167634006295 major facilitator superfamily transporter; Provisional; Region: PRK05122 1167634006296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634006297 putative substrate translocation pore; other site 1167634006298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634006299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634006300 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 1167634006301 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1167634006302 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1167634006303 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1167634006304 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1167634006305 NAD binding site [chemical binding]; other site 1167634006306 putative active site [active] 1167634006307 substrate binding site [chemical binding]; other site 1167634006308 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1167634006309 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1167634006310 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1167634006311 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1167634006312 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1167634006313 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1167634006314 active site residue [active] 1167634006315 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1167634006316 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1167634006317 putative ligand binding site [chemical binding]; other site 1167634006318 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1167634006319 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1167634006320 Walker A/P-loop; other site 1167634006321 ATP binding site [chemical binding]; other site 1167634006322 Q-loop/lid; other site 1167634006323 ABC transporter signature motif; other site 1167634006324 Walker B; other site 1167634006325 D-loop; other site 1167634006326 H-loop/switch region; other site 1167634006327 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1167634006328 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1167634006329 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634006330 TM-ABC transporter signature motif; other site 1167634006331 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634006332 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1167634006333 TM-ABC transporter signature motif; other site 1167634006334 cytosine deaminase; Validated; Region: PRK07572 1167634006335 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1167634006336 active site 1167634006337 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1167634006338 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1167634006339 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1167634006340 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1167634006341 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1167634006342 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1167634006343 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1167634006344 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1167634006345 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1167634006346 homotrimer interaction site [polypeptide binding]; other site 1167634006347 putative active site [active] 1167634006348 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1167634006349 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1167634006350 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1167634006351 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1167634006352 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1167634006353 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1167634006354 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1167634006355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006356 dimer interface [polypeptide binding]; other site 1167634006357 conserved gate region; other site 1167634006358 putative PBP binding loops; other site 1167634006359 ABC-ATPase subunit interface; other site 1167634006360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006361 dimer interface [polypeptide binding]; other site 1167634006362 conserved gate region; other site 1167634006363 putative PBP binding loops; other site 1167634006364 ABC-ATPase subunit interface; other site 1167634006365 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1167634006366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634006367 Walker A/P-loop; other site 1167634006368 ATP binding site [chemical binding]; other site 1167634006369 Q-loop/lid; other site 1167634006370 ABC transporter signature motif; other site 1167634006371 Walker B; other site 1167634006372 D-loop; other site 1167634006373 H-loop/switch region; other site 1167634006374 TOBE domain; Region: TOBE_2; pfam08402 1167634006375 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1167634006376 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1167634006377 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1167634006378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634006379 DNA-binding site [nucleotide binding]; DNA binding site 1167634006380 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1167634006381 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1167634006382 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1167634006383 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1167634006384 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1167634006385 nucleotide binding site [chemical binding]; other site 1167634006386 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1167634006387 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634006388 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634006389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634006390 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1167634006391 substrate binding pocket [chemical binding]; other site 1167634006392 dimerization interface [polypeptide binding]; other site 1167634006393 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634006394 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634006395 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1167634006396 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1167634006397 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1167634006398 putative ligand binding site [chemical binding]; other site 1167634006399 NAD binding site [chemical binding]; other site 1167634006400 dimerization interface [polypeptide binding]; other site 1167634006401 catalytic site [active] 1167634006402 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1167634006403 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1167634006404 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1167634006405 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1167634006406 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1167634006407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1167634006408 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1167634006409 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1167634006410 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1167634006411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006412 dimer interface [polypeptide binding]; other site 1167634006413 conserved gate region; other site 1167634006414 putative PBP binding loops; other site 1167634006415 ABC-ATPase subunit interface; other site 1167634006416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1167634006417 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1167634006418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006419 dimer interface [polypeptide binding]; other site 1167634006420 conserved gate region; other site 1167634006421 putative PBP binding loops; other site 1167634006422 ABC-ATPase subunit interface; other site 1167634006423 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1167634006424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634006425 Walker A/P-loop; other site 1167634006426 ATP binding site [chemical binding]; other site 1167634006427 Q-loop/lid; other site 1167634006428 ABC transporter signature motif; other site 1167634006429 Walker B; other site 1167634006430 D-loop; other site 1167634006431 H-loop/switch region; other site 1167634006432 TOBE domain; Region: TOBE_2; pfam08402 1167634006433 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634006434 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1167634006435 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634006436 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1167634006437 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1167634006438 active site 1167634006439 substrate binding site [chemical binding]; other site 1167634006440 FMN binding site [chemical binding]; other site 1167634006441 putative catalytic residues [active] 1167634006442 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1167634006443 acylphosphatase; Provisional; Region: PRK14424 1167634006444 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1167634006445 EamA-like transporter family; Region: EamA; pfam00892 1167634006446 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1167634006447 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1167634006448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634006449 catalytic residue [active] 1167634006450 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634006451 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634006452 Walker A/P-loop; other site 1167634006453 ATP binding site [chemical binding]; other site 1167634006454 Q-loop/lid; other site 1167634006455 ABC transporter signature motif; other site 1167634006456 Walker B; other site 1167634006457 D-loop; other site 1167634006458 H-loop/switch region; other site 1167634006459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006460 dimer interface [polypeptide binding]; other site 1167634006461 conserved gate region; other site 1167634006462 putative PBP binding loops; other site 1167634006463 ABC-ATPase subunit interface; other site 1167634006464 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1167634006465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006466 dimer interface [polypeptide binding]; other site 1167634006467 conserved gate region; other site 1167634006468 putative PBP binding loops; other site 1167634006469 ABC-ATPase subunit interface; other site 1167634006470 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634006471 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634006472 substrate binding pocket [chemical binding]; other site 1167634006473 membrane-bound complex binding site; other site 1167634006474 hinge residues; other site 1167634006475 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1167634006476 putative dimerization interface [polypeptide binding]; other site 1167634006477 Predicted membrane protein [Function unknown]; Region: COG2259 1167634006478 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1167634006479 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1167634006480 active site 1167634006481 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 1167634006482 Pirin-related protein [General function prediction only]; Region: COG1741 1167634006483 Pirin; Region: Pirin; pfam02678 1167634006484 Transmembrane secretion effector; Region: MFS_3; pfam05977 1167634006485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634006486 putative substrate translocation pore; other site 1167634006487 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1167634006488 Isochorismatase family; Region: Isochorismatase; pfam00857 1167634006489 catalytic triad [active] 1167634006490 dimer interface [polypeptide binding]; other site 1167634006491 conserved cis-peptide bond; other site 1167634006492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634006493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634006494 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634006495 putative effector binding pocket; other site 1167634006496 dimerization interface [polypeptide binding]; other site 1167634006497 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1167634006498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634006499 ATP binding site [chemical binding]; other site 1167634006500 Mg2+ binding site [ion binding]; other site 1167634006501 G-X-G motif; other site 1167634006502 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1167634006503 anchoring element; other site 1167634006504 dimer interface [polypeptide binding]; other site 1167634006505 ATP binding site [chemical binding]; other site 1167634006506 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1167634006507 active site 1167634006508 putative metal-binding site [ion binding]; other site 1167634006509 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1167634006510 DNA polymerase III subunit beta; Validated; Region: PRK05643 1167634006511 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1167634006512 putative DNA binding surface [nucleotide binding]; other site 1167634006513 dimer interface [polypeptide binding]; other site 1167634006514 beta-clamp/clamp loader binding surface; other site 1167634006515 beta-clamp/translesion DNA polymerase binding surface; other site 1167634006516 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1167634006517 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1167634006518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634006519 Walker A motif; other site 1167634006520 ATP binding site [chemical binding]; other site 1167634006521 Walker B motif; other site 1167634006522 arginine finger; other site 1167634006523 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1167634006524 DnaA box-binding interface [nucleotide binding]; other site 1167634006525 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1167634006526 Ribonuclease P; Region: Ribonuclease_P; cl00457 1167634006527 membrane protein insertase; Provisional; Region: PRK01318 1167634006528 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1167634006529 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1167634006530 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1167634006531 tetramer interface [polypeptide binding]; other site 1167634006532 heme binding pocket [chemical binding]; other site 1167634006533 NADPH binding site [chemical binding]; other site 1167634006534 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1167634006535 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1167634006536 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634006537 catalytic residue [active] 1167634006538 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1167634006539 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1167634006540 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1167634006541 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1167634006542 metal binding site [ion binding]; metal-binding site 1167634006543 putative dimer interface [polypeptide binding]; other site 1167634006544 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1167634006545 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634006546 Walker A/P-loop; other site 1167634006547 ATP binding site [chemical binding]; other site 1167634006548 Q-loop/lid; other site 1167634006549 ABC transporter signature motif; other site 1167634006550 Walker B; other site 1167634006551 D-loop; other site 1167634006552 H-loop/switch region; other site 1167634006553 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1167634006554 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1167634006555 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634006556 Walker A/P-loop; other site 1167634006557 ATP binding site [chemical binding]; other site 1167634006558 Q-loop/lid; other site 1167634006559 ABC transporter signature motif; other site 1167634006560 Walker B; other site 1167634006561 D-loop; other site 1167634006562 H-loop/switch region; other site 1167634006563 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1167634006564 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1167634006565 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1167634006566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006567 dimer interface [polypeptide binding]; other site 1167634006568 conserved gate region; other site 1167634006569 putative PBP binding loops; other site 1167634006570 ABC-ATPase subunit interface; other site 1167634006571 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634006572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006573 dimer interface [polypeptide binding]; other site 1167634006574 conserved gate region; other site 1167634006575 putative PBP binding loops; other site 1167634006576 ABC-ATPase subunit interface; other site 1167634006577 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1167634006578 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1167634006579 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1167634006580 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1167634006581 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1167634006582 G1 box; other site 1167634006583 GTP/Mg2+ binding site [chemical binding]; other site 1167634006584 Switch I region; other site 1167634006585 G2 box; other site 1167634006586 Switch II region; other site 1167634006587 G3 box; other site 1167634006588 G4 box; other site 1167634006589 G5 box; other site 1167634006590 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1167634006591 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1167634006592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634006593 Coenzyme A binding pocket [chemical binding]; other site 1167634006594 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1167634006595 Cl- selectivity filter; other site 1167634006596 Cl- binding residues [ion binding]; other site 1167634006597 pore gating glutamate residue; other site 1167634006598 dimer interface [polypeptide binding]; other site 1167634006599 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1167634006600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634006601 active site 1167634006602 phosphorylation site [posttranslational modification] 1167634006603 intermolecular recognition site; other site 1167634006604 dimerization interface [polypeptide binding]; other site 1167634006605 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634006606 DNA binding site [nucleotide binding] 1167634006607 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1167634006608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634006609 dimer interface [polypeptide binding]; other site 1167634006610 phosphorylation site [posttranslational modification] 1167634006611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634006612 ATP binding site [chemical binding]; other site 1167634006613 Mg2+ binding site [ion binding]; other site 1167634006614 G-X-G motif; other site 1167634006615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634006616 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1167634006617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1167634006618 methionine aminotransferase; Validated; Region: PRK09082 1167634006619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634006620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634006621 homodimer interface [polypeptide binding]; other site 1167634006622 catalytic residue [active] 1167634006623 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1167634006624 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1167634006625 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1167634006626 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1167634006627 DNA-binding site [nucleotide binding]; DNA binding site 1167634006628 RNA-binding motif; other site 1167634006629 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1167634006630 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1167634006631 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1167634006632 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1167634006633 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1167634006634 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1167634006635 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1167634006636 P-loop; other site 1167634006637 Magnesium ion binding site [ion binding]; other site 1167634006638 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1167634006639 Magnesium ion binding site [ion binding]; other site 1167634006640 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1167634006641 Coenzyme A binding pocket [chemical binding]; other site 1167634006642 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1167634006643 ParB-like nuclease domain; Region: ParB; smart00470 1167634006644 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1167634006645 active site 1167634006646 homotetramer interface [polypeptide binding]; other site 1167634006647 homodimer interface [polypeptide binding]; other site 1167634006648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634006649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634006650 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1167634006651 putative dimerization interface [polypeptide binding]; other site 1167634006652 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1167634006653 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1167634006654 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1167634006655 homodimer interface [polypeptide binding]; other site 1167634006656 substrate-cofactor binding pocket; other site 1167634006657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634006658 catalytic residue [active] 1167634006659 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1167634006660 active site residue [active] 1167634006661 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1167634006662 active site residue [active] 1167634006663 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1167634006664 active site residue [active] 1167634006665 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1167634006666 active site residue [active] 1167634006667 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634006668 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1167634006669 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1167634006670 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1167634006671 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1167634006672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634006673 dimer interface [polypeptide binding]; other site 1167634006674 conserved gate region; other site 1167634006675 putative PBP binding loops; other site 1167634006676 ABC-ATPase subunit interface; other site 1167634006677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1167634006678 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1167634006679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634006680 Walker A/P-loop; other site 1167634006681 ATP binding site [chemical binding]; other site 1167634006682 Q-loop/lid; other site 1167634006683 ABC transporter signature motif; other site 1167634006684 Walker B; other site 1167634006685 D-loop; other site 1167634006686 H-loop/switch region; other site 1167634006687 TOBE domain; Region: TOBE_2; pfam08402 1167634006688 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1167634006689 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1167634006690 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1167634006691 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1167634006692 active site 1167634006693 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1167634006694 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1167634006695 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1167634006696 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 1167634006697 NAD(P) binding site [chemical binding]; other site 1167634006698 catalytic residues [active] 1167634006699 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1167634006700 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 1167634006701 putative active site [active] 1167634006702 metal binding site [ion binding]; metal-binding site 1167634006703 elongation factor Tu; Reviewed; Region: PRK00049 1167634006704 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1167634006705 G1 box; other site 1167634006706 GEF interaction site [polypeptide binding]; other site 1167634006707 GTP/Mg2+ binding site [chemical binding]; other site 1167634006708 Switch I region; other site 1167634006709 G2 box; other site 1167634006710 G3 box; other site 1167634006711 Switch II region; other site 1167634006712 G4 box; other site 1167634006713 G5 box; other site 1167634006714 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1167634006715 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1167634006716 Antibiotic Binding Site [chemical binding]; other site 1167634006717 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1167634006718 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1167634006719 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1167634006720 putative homodimer interface [polypeptide binding]; other site 1167634006721 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1167634006722 heterodimer interface [polypeptide binding]; other site 1167634006723 homodimer interface [polypeptide binding]; other site 1167634006724 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1167634006725 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1167634006726 23S rRNA interface [nucleotide binding]; other site 1167634006727 L7/L12 interface [polypeptide binding]; other site 1167634006728 putative thiostrepton binding site; other site 1167634006729 L25 interface [polypeptide binding]; other site 1167634006730 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1167634006731 mRNA/rRNA interface [nucleotide binding]; other site 1167634006732 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1167634006733 23S rRNA interface [nucleotide binding]; other site 1167634006734 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1167634006735 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1167634006736 core dimer interface [polypeptide binding]; other site 1167634006737 peripheral dimer interface [polypeptide binding]; other site 1167634006738 L10 interface [polypeptide binding]; other site 1167634006739 L11 interface [polypeptide binding]; other site 1167634006740 putative EF-Tu interaction site [polypeptide binding]; other site 1167634006741 putative EF-G interaction site [polypeptide binding]; other site 1167634006742 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1167634006743 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1167634006744 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1167634006745 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1167634006746 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1167634006747 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1167634006748 RPB3 interaction site [polypeptide binding]; other site 1167634006749 RPB1 interaction site [polypeptide binding]; other site 1167634006750 RPB11 interaction site [polypeptide binding]; other site 1167634006751 RPB10 interaction site [polypeptide binding]; other site 1167634006752 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1167634006753 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1167634006754 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1167634006755 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1167634006756 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1167634006757 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1167634006758 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1167634006759 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1167634006760 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1167634006761 DNA binding site [nucleotide binding] 1167634006762 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1167634006763 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1167634006764 substrate binding site [chemical binding]; other site 1167634006765 activation loop (A-loop); other site 1167634006766 CHASE2 domain; Region: CHASE2; pfam05226 1167634006767 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1167634006768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634006769 dimer interface [polypeptide binding]; other site 1167634006770 phosphorylation site [posttranslational modification] 1167634006771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634006772 ATP binding site [chemical binding]; other site 1167634006773 Mg2+ binding site [ion binding]; other site 1167634006774 G-X-G motif; other site 1167634006775 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1167634006776 FecR protein; Region: FecR; pfam04773 1167634006777 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634006778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634006779 active site 1167634006780 phosphorylation site [posttranslational modification] 1167634006781 intermolecular recognition site; other site 1167634006782 dimerization interface [polypeptide binding]; other site 1167634006783 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634006784 DNA binding site [nucleotide binding] 1167634006785 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634006786 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1167634006787 DNA binding site [nucleotide binding] 1167634006788 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1167634006789 S17 interaction site [polypeptide binding]; other site 1167634006790 S8 interaction site; other site 1167634006791 16S rRNA interaction site [nucleotide binding]; other site 1167634006792 streptomycin interaction site [chemical binding]; other site 1167634006793 23S rRNA interaction site [nucleotide binding]; other site 1167634006794 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1167634006795 30S ribosomal protein S7; Validated; Region: PRK05302 1167634006796 elongation factor G; Reviewed; Region: PRK00007 1167634006797 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1167634006798 G1 box; other site 1167634006799 putative GEF interaction site [polypeptide binding]; other site 1167634006800 GTP/Mg2+ binding site [chemical binding]; other site 1167634006801 Switch I region; other site 1167634006802 G2 box; other site 1167634006803 G3 box; other site 1167634006804 Switch II region; other site 1167634006805 G4 box; other site 1167634006806 G5 box; other site 1167634006807 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1167634006808 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1167634006809 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1167634006810 elongation factor Tu; Reviewed; Region: PRK00049 1167634006811 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1167634006812 G1 box; other site 1167634006813 GEF interaction site [polypeptide binding]; other site 1167634006814 GTP/Mg2+ binding site [chemical binding]; other site 1167634006815 Switch I region; other site 1167634006816 G2 box; other site 1167634006817 G3 box; other site 1167634006818 Switch II region; other site 1167634006819 G4 box; other site 1167634006820 G5 box; other site 1167634006821 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1167634006822 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1167634006823 Antibiotic Binding Site [chemical binding]; other site 1167634006824 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1167634006825 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1167634006826 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1167634006827 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1167634006828 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1167634006829 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1167634006830 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1167634006831 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1167634006832 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1167634006833 putative translocon binding site; other site 1167634006834 protein-rRNA interface [nucleotide binding]; other site 1167634006835 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1167634006836 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1167634006837 G-X-X-G motif; other site 1167634006838 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1167634006839 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1167634006840 23S rRNA interface [nucleotide binding]; other site 1167634006841 5S rRNA interface [nucleotide binding]; other site 1167634006842 putative antibiotic binding site [chemical binding]; other site 1167634006843 L25 interface [polypeptide binding]; other site 1167634006844 L27 interface [polypeptide binding]; other site 1167634006845 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1167634006846 23S rRNA interface [nucleotide binding]; other site 1167634006847 putative translocon interaction site; other site 1167634006848 signal recognition particle (SRP54) interaction site; other site 1167634006849 L23 interface [polypeptide binding]; other site 1167634006850 trigger factor interaction site; other site 1167634006851 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1167634006852 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634006853 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634006854 TM-ABC transporter signature motif; other site 1167634006855 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634006856 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634006857 TM-ABC transporter signature motif; other site 1167634006858 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634006859 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634006860 Walker A/P-loop; other site 1167634006861 ATP binding site [chemical binding]; other site 1167634006862 Q-loop/lid; other site 1167634006863 ABC transporter signature motif; other site 1167634006864 Walker B; other site 1167634006865 D-loop; other site 1167634006866 H-loop/switch region; other site 1167634006867 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634006868 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634006869 Walker A/P-loop; other site 1167634006870 ATP binding site [chemical binding]; other site 1167634006871 Q-loop/lid; other site 1167634006872 ABC transporter signature motif; other site 1167634006873 Walker B; other site 1167634006874 D-loop; other site 1167634006875 H-loop/switch region; other site 1167634006876 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634006877 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 1167634006878 putative ligand binding site [chemical binding]; other site 1167634006879 short chain dehydrogenase; Validated; Region: PRK05855 1167634006880 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1167634006881 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1167634006882 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634006883 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1167634006884 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1167634006885 homodimer interface [polypeptide binding]; other site 1167634006886 substrate-cofactor binding pocket; other site 1167634006887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634006888 catalytic residue [active] 1167634006889 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1167634006890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634006891 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634006892 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634006893 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1167634006894 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1167634006895 tetramerization interface [polypeptide binding]; other site 1167634006896 NAD(P) binding site [chemical binding]; other site 1167634006897 catalytic residues [active] 1167634006898 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1167634006899 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1167634006900 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1167634006901 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1167634006902 RNA binding site [nucleotide binding]; other site 1167634006903 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1167634006904 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1167634006905 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1167634006906 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1167634006907 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1167634006908 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1167634006909 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1167634006910 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1167634006911 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1167634006912 5S rRNA interface [nucleotide binding]; other site 1167634006913 L27 interface [polypeptide binding]; other site 1167634006914 23S rRNA interface [nucleotide binding]; other site 1167634006915 L5 interface [polypeptide binding]; other site 1167634006916 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1167634006917 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1167634006918 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1167634006919 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1167634006920 23S rRNA binding site [nucleotide binding]; other site 1167634006921 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1167634006922 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1167634006923 SecY translocase; Region: SecY; pfam00344 1167634006924 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1167634006925 rRNA binding site [nucleotide binding]; other site 1167634006926 predicted 30S ribosome binding site; other site 1167634006927 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1167634006928 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1167634006929 30S ribosomal protein S11; Validated; Region: PRK05309 1167634006930 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1167634006931 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1167634006932 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1167634006933 RNA binding surface [nucleotide binding]; other site 1167634006934 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1167634006935 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1167634006936 alphaNTD homodimer interface [polypeptide binding]; other site 1167634006937 alphaNTD - beta interaction site [polypeptide binding]; other site 1167634006938 alphaNTD - beta' interaction site [polypeptide binding]; other site 1167634006939 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1167634006940 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1167634006941 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1167634006942 nucleotide binding site/active site [active] 1167634006943 HIT family signature motif; other site 1167634006944 catalytic residue [active] 1167634006945 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1167634006946 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1167634006947 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1167634006948 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1167634006949 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1167634006950 DsbD alpha interface [polypeptide binding]; other site 1167634006951 catalytic residues [active] 1167634006952 EamA-like transporter family; Region: EamA; pfam00892 1167634006953 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634006954 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1167634006955 dimer interface [polypeptide binding]; other site 1167634006956 active site 1167634006957 aspartate-rich active site metal binding site; other site 1167634006958 allosteric magnesium binding site [ion binding]; other site 1167634006959 Schiff base residues; other site 1167634006960 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1167634006961 G1 box; other site 1167634006962 GTP/Mg2+ binding site [chemical binding]; other site 1167634006963 Switch I region; other site 1167634006964 G2 box; other site 1167634006965 G3 box; other site 1167634006966 Switch II region; other site 1167634006967 G4 box; other site 1167634006968 G5 box; other site 1167634006969 Cytochrome c; Region: Cytochrom_C; cl11414 1167634006970 Cytochrome c; Region: Cytochrom_C; cl11414 1167634006971 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1167634006972 ResB-like family; Region: ResB; pfam05140 1167634006973 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1167634006974 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1167634006975 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1167634006976 active site 1167634006977 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1167634006978 substrate binding site [chemical binding]; other site 1167634006979 catalytic residues [active] 1167634006980 dimer interface [polypeptide binding]; other site 1167634006981 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1167634006982 putative iron binding site [ion binding]; other site 1167634006983 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1167634006984 Transglycosylase; Region: Transgly; pfam00912 1167634006985 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1167634006986 shikimate kinase; Reviewed; Region: aroK; PRK00131 1167634006987 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1167634006988 ADP binding site [chemical binding]; other site 1167634006989 magnesium binding site [ion binding]; other site 1167634006990 putative shikimate binding site; other site 1167634006991 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1167634006992 active site 1167634006993 dimer interface [polypeptide binding]; other site 1167634006994 metal binding site [ion binding]; metal-binding site 1167634006995 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1167634006996 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1167634006997 Zn2+ binding site [ion binding]; other site 1167634006998 Mg2+ binding site [ion binding]; other site 1167634006999 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1167634007000 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1167634007001 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634007002 putative C-terminal domain interface [polypeptide binding]; other site 1167634007003 putative GSH binding site (G-site) [chemical binding]; other site 1167634007004 putative dimer interface [polypeptide binding]; other site 1167634007005 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1167634007006 putative substrate binding pocket (H-site) [chemical binding]; other site 1167634007007 putative N-terminal domain interface [polypeptide binding]; other site 1167634007008 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1167634007009 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1167634007010 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1167634007011 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1167634007012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634007013 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634007014 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1167634007015 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1167634007016 dimer interface [polypeptide binding]; other site 1167634007017 ssDNA binding site [nucleotide binding]; other site 1167634007018 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1167634007019 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1167634007020 active site 1167634007021 catalytic residues [active] 1167634007022 DNA binding site [nucleotide binding] 1167634007023 Int/Topo IB signature motif; other site 1167634007024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 1167634007025 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1167634007026 DNA binding site [nucleotide binding] 1167634007027 active site 1167634007028 Int/Topo IB signature motif; other site 1167634007029 catalytic residues [active] 1167634007030 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1167634007031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634007032 dimer interface [polypeptide binding]; other site 1167634007033 conserved gate region; other site 1167634007034 putative PBP binding loops; other site 1167634007035 ABC-ATPase subunit interface; other site 1167634007036 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1167634007037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634007038 S-adenosylmethionine binding site [chemical binding]; other site 1167634007039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634007040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634007041 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1167634007042 catalytic triad [active] 1167634007043 conserved cis-peptide bond; other site 1167634007044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634007045 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1167634007046 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1167634007047 active site 1167634007048 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1167634007049 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634007050 DNA-binding site [nucleotide binding]; DNA binding site 1167634007051 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1167634007052 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1167634007053 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1167634007054 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1167634007055 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1167634007056 UbiA prenyltransferase family; Region: UbiA; pfam01040 1167634007057 aspartate aminotransferase; Provisional; Region: PRK05764 1167634007058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634007059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634007060 homodimer interface [polypeptide binding]; other site 1167634007061 catalytic residue [active] 1167634007062 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1167634007063 GAF domain; Region: GAF_2; pfam13185 1167634007064 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1167634007065 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1167634007066 dimer interface [polypeptide binding]; other site 1167634007067 active site 1167634007068 catalytic residue [active] 1167634007069 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1167634007070 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1167634007071 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1167634007072 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1167634007073 putative di-iron ligands [ion binding]; other site 1167634007074 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 1167634007075 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1167634007076 dimer interface [polypeptide binding]; other site 1167634007077 active site 1167634007078 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 1167634007079 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1167634007080 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1167634007081 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1167634007082 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1167634007083 dimer interface [polypeptide binding]; other site 1167634007084 anticodon binding site; other site 1167634007085 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1167634007086 homodimer interface [polypeptide binding]; other site 1167634007087 motif 1; other site 1167634007088 active site 1167634007089 motif 2; other site 1167634007090 GAD domain; Region: GAD; pfam02938 1167634007091 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1167634007092 motif 3; other site 1167634007093 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1167634007094 putative catalytic site [active] 1167634007095 putative metal binding site [ion binding]; other site 1167634007096 putative phosphate binding site [ion binding]; other site 1167634007097 putative metal binding site [ion binding]; other site 1167634007098 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1167634007099 putative active site [active] 1167634007100 catalytic site [active] 1167634007101 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1167634007102 putative active site [active] 1167634007103 catalytic site [active] 1167634007104 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634007105 EamA-like transporter family; Region: EamA; pfam00892 1167634007106 EamA-like transporter family; Region: EamA; pfam00892 1167634007107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634007108 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634007109 putative substrate translocation pore; other site 1167634007110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634007111 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1167634007112 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1167634007113 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1167634007114 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1167634007115 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1167634007116 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1167634007117 NAD binding site [chemical binding]; other site 1167634007118 putative substrate binding site 2 [chemical binding]; other site 1167634007119 putative substrate binding site 1 [chemical binding]; other site 1167634007120 active site 1167634007121 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1167634007122 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1167634007123 NAD(P) binding site [chemical binding]; other site 1167634007124 homodimer interface [polypeptide binding]; other site 1167634007125 substrate binding site [chemical binding]; other site 1167634007126 active site 1167634007127 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1167634007128 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1167634007129 inhibitor-cofactor binding pocket; inhibition site 1167634007130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634007131 catalytic residue [active] 1167634007132 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1167634007133 ligand binding site; other site 1167634007134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1167634007135 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1167634007136 Ligand Binding Site [chemical binding]; other site 1167634007137 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1167634007138 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1167634007139 putative active site [active] 1167634007140 oxyanion strand; other site 1167634007141 catalytic triad [active] 1167634007142 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1167634007143 substrate binding site [chemical binding]; other site 1167634007144 glutamase interaction surface [polypeptide binding]; other site 1167634007145 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1167634007146 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1167634007147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1167634007148 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1167634007149 pseudaminic acid synthase; Region: PseI; TIGR03586 1167634007150 NeuB family; Region: NeuB; pfam03102 1167634007151 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1167634007152 NeuB binding interface [polypeptide binding]; other site 1167634007153 putative substrate binding site [chemical binding]; other site 1167634007154 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1167634007155 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1167634007156 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1167634007157 active site 1167634007158 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1167634007159 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1167634007160 Mg++ binding site [ion binding]; other site 1167634007161 putative catalytic motif [active] 1167634007162 putative substrate binding site [chemical binding]; other site 1167634007163 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1167634007164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634007165 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1167634007166 NAD(P) binding site [chemical binding]; other site 1167634007167 homodimer interface [polypeptide binding]; other site 1167634007168 substrate binding site [chemical binding]; other site 1167634007169 active site 1167634007170 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1167634007171 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1167634007172 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1167634007173 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1167634007174 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1167634007175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634007176 NAD(P) binding site [chemical binding]; other site 1167634007177 active site 1167634007178 pantothenate kinase; Reviewed; Region: PRK13328 1167634007179 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1167634007180 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1167634007181 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1167634007182 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1167634007183 Permease; Region: Permease; pfam02405 1167634007184 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1167634007185 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1167634007186 Walker A/P-loop; other site 1167634007187 ATP binding site [chemical binding]; other site 1167634007188 Q-loop/lid; other site 1167634007189 ABC transporter signature motif; other site 1167634007190 Walker B; other site 1167634007191 D-loop; other site 1167634007192 H-loop/switch region; other site 1167634007193 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1167634007194 mce related protein; Region: MCE; pfam02470 1167634007195 Protein of unknown function (DUF330); Region: DUF330; cl01135 1167634007196 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1167634007197 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1167634007198 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1167634007199 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1167634007200 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1167634007201 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1167634007202 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1167634007203 homodimer interface [polypeptide binding]; other site 1167634007204 substrate-cofactor binding pocket; other site 1167634007205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634007206 catalytic residue [active] 1167634007207 Protein of unknown function (DUF493); Region: DUF493; cl01102 1167634007208 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1167634007209 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1167634007210 Sel1-like repeats; Region: SEL1; smart00671 1167634007211 Sel1-like repeats; Region: SEL1; smart00671 1167634007212 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1167634007213 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1167634007214 substrate binding site; other site 1167634007215 tetramer interface; other site 1167634007216 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1167634007217 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1167634007218 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1167634007219 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1167634007220 dimer interface [polypeptide binding]; other site 1167634007221 active site 1167634007222 CoA binding pocket [chemical binding]; other site 1167634007223 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1167634007224 putative trimer interface [polypeptide binding]; other site 1167634007225 putative CoA binding site [chemical binding]; other site 1167634007226 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1167634007227 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1167634007228 lipoyl synthase; Provisional; Region: PRK05481 1167634007229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1167634007230 FeS/SAM binding site; other site 1167634007231 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1167634007232 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1167634007233 NAD binding site [chemical binding]; other site 1167634007234 substrate binding site [chemical binding]; other site 1167634007235 homodimer interface [polypeptide binding]; other site 1167634007236 active site 1167634007237 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1167634007238 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1167634007239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634007240 Walker A motif; other site 1167634007241 ATP binding site [chemical binding]; other site 1167634007242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634007243 Walker B motif; other site 1167634007244 arginine finger; other site 1167634007245 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1167634007246 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1167634007247 active site 1167634007248 HslU subunit interaction site [polypeptide binding]; other site 1167634007249 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1167634007250 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1167634007251 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1167634007252 P-loop, Walker A motif; other site 1167634007253 Base recognition motif; other site 1167634007254 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1167634007255 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1167634007256 metal binding site 2 [ion binding]; metal-binding site 1167634007257 putative DNA binding helix; other site 1167634007258 metal binding site 1 [ion binding]; metal-binding site 1167634007259 dimer interface [polypeptide binding]; other site 1167634007260 structural Zn2+ binding site [ion binding]; other site 1167634007261 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1167634007262 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1167634007263 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1167634007264 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1167634007265 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1167634007266 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1167634007267 intersubunit interface [polypeptide binding]; other site 1167634007268 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 1167634007269 High-affinity nickel-transport protein; Region: NicO; cl00964 1167634007270 High-affinity nickel-transport protein; Region: NicO; cl00964 1167634007271 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1167634007272 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1167634007273 active site 1167634007274 DNA binding site [nucleotide binding] 1167634007275 Int/Topo IB signature motif; other site 1167634007276 Protein of unknown function, DUF484; Region: DUF484; cl17449 1167634007277 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1167634007278 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1167634007279 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1167634007280 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1167634007281 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1167634007282 putative acyl-acceptor binding pocket; other site 1167634007283 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1167634007284 putative acyl-acceptor binding pocket; other site 1167634007285 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1167634007286 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1167634007287 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1167634007288 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1167634007289 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1167634007290 Amidase; Region: Amidase; cl11426 1167634007291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634007292 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634007293 putative substrate translocation pore; other site 1167634007294 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634007295 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1167634007296 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634007297 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1167634007298 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634007299 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634007300 TM-ABC transporter signature motif; other site 1167634007301 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634007302 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634007303 Walker A/P-loop; other site 1167634007304 ATP binding site [chemical binding]; other site 1167634007305 Q-loop/lid; other site 1167634007306 ABC transporter signature motif; other site 1167634007307 Walker B; other site 1167634007308 D-loop; other site 1167634007309 H-loop/switch region; other site 1167634007310 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634007311 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634007312 Walker A/P-loop; other site 1167634007313 ATP binding site [chemical binding]; other site 1167634007314 Q-loop/lid; other site 1167634007315 ABC transporter signature motif; other site 1167634007316 Walker B; other site 1167634007317 D-loop; other site 1167634007318 H-loop/switch region; other site 1167634007319 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634007320 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634007321 TM-ABC transporter signature motif; other site 1167634007322 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634007323 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 1167634007324 putative ligand binding site [chemical binding]; other site 1167634007325 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 1167634007326 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1167634007327 putative active site [active] 1167634007328 putative catalytic site [active] 1167634007329 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1167634007330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634007331 DNA-binding site [nucleotide binding]; DNA binding site 1167634007332 FCD domain; Region: FCD; pfam07729 1167634007333 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1167634007334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634007335 transcriptional activator TtdR; Provisional; Region: PRK09801 1167634007336 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1167634007337 putative effector binding pocket; other site 1167634007338 putative dimerization interface [polypeptide binding]; other site 1167634007339 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634007340 isopropylmalate isomerase large subunit; Provisional; Region: PRK12466 1167634007341 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1167634007342 substrate binding site [chemical binding]; other site 1167634007343 ligand binding site [chemical binding]; other site 1167634007344 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1167634007345 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1167634007346 substrate binding site [chemical binding]; other site 1167634007347 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1167634007348 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 1167634007349 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634007350 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1167634007351 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1167634007352 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1167634007353 homotetramer interface [polypeptide binding]; other site 1167634007354 ligand binding site [chemical binding]; other site 1167634007355 catalytic site [active] 1167634007356 NAD binding site [chemical binding]; other site 1167634007357 Membrane protein of unknown function; Region: DUF360; pfam04020 1167634007358 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1167634007359 FAD binding site [chemical binding]; other site 1167634007360 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634007361 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1167634007362 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1167634007363 active site 1167634007364 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1167634007365 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1167634007366 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1167634007367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1167634007368 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1167634007369 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1167634007370 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1167634007371 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1167634007372 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1167634007373 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1167634007374 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1167634007375 catalytic residue [active] 1167634007376 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13297 1167634007377 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1167634007378 active site 1167634007379 NTP binding site [chemical binding]; other site 1167634007380 metal binding triad [ion binding]; metal-binding site 1167634007381 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1167634007382 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 1167634007383 helicase 45; Provisional; Region: PTZ00424 1167634007384 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1167634007385 ATP binding site [chemical binding]; other site 1167634007386 Mg++ binding site [ion binding]; other site 1167634007387 motif III; other site 1167634007388 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634007389 nucleotide binding region [chemical binding]; other site 1167634007390 ATP-binding site [chemical binding]; other site 1167634007391 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1167634007392 ligand binding site [chemical binding]; other site 1167634007393 active site 1167634007394 UGI interface [polypeptide binding]; other site 1167634007395 catalytic site [active] 1167634007396 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1167634007397 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1167634007398 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1167634007399 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1167634007400 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 1167634007401 classical (c) SDRs; Region: SDR_c; cd05233 1167634007402 NAD(P) binding site [chemical binding]; other site 1167634007403 active site 1167634007404 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1167634007405 active site 1167634007406 metal binding site [ion binding]; metal-binding site 1167634007407 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1167634007408 Predicted periplasmic protein [Function unknown]; Region: COG3904 1167634007409 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1167634007410 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1167634007411 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 1167634007412 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1167634007413 nucleotide binding site/active site [active] 1167634007414 HIT family signature motif; other site 1167634007415 catalytic residue [active] 1167634007416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634007417 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1167634007418 Coenzyme A binding pocket [chemical binding]; other site 1167634007419 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1167634007420 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1167634007421 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1167634007422 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1167634007423 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634007424 putative DNA binding site [nucleotide binding]; other site 1167634007425 putative Zn2+ binding site [ion binding]; other site 1167634007426 Predicted transporter component [General function prediction only]; Region: COG2391 1167634007427 Sulphur transport; Region: Sulf_transp; pfam04143 1167634007428 Predicted transporter component [General function prediction only]; Region: COG2391 1167634007429 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1167634007430 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1167634007431 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634007432 acyl-activating enzyme (AAE) consensus motif; other site 1167634007433 AMP binding site [chemical binding]; other site 1167634007434 active site 1167634007435 CoA binding site [chemical binding]; other site 1167634007436 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634007437 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634007438 Walker A/P-loop; other site 1167634007439 ATP binding site [chemical binding]; other site 1167634007440 Q-loop/lid; other site 1167634007441 ABC transporter signature motif; other site 1167634007442 Walker B; other site 1167634007443 D-loop; other site 1167634007444 H-loop/switch region; other site 1167634007445 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1167634007446 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634007447 putative ligand binding site [chemical binding]; other site 1167634007448 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634007449 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634007450 TM-ABC transporter signature motif; other site 1167634007451 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634007452 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634007453 TM-ABC transporter signature motif; other site 1167634007454 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634007455 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634007456 Walker A/P-loop; other site 1167634007457 ATP binding site [chemical binding]; other site 1167634007458 Q-loop/lid; other site 1167634007459 ABC transporter signature motif; other site 1167634007460 Walker B; other site 1167634007461 D-loop; other site 1167634007462 H-loop/switch region; other site 1167634007463 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1167634007464 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634007465 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1167634007466 acyl-activating enzyme (AAE) consensus motif; other site 1167634007467 putative AMP binding site [chemical binding]; other site 1167634007468 putative active site [active] 1167634007469 putative CoA binding site [chemical binding]; other site 1167634007470 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1167634007471 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1167634007472 ligand binding site [chemical binding]; other site 1167634007473 flexible hinge region; other site 1167634007474 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1167634007475 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1167634007476 MarR family; Region: MarR; pfam01047 1167634007477 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1167634007478 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634007479 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634007480 Walker A/P-loop; other site 1167634007481 ATP binding site [chemical binding]; other site 1167634007482 Q-loop/lid; other site 1167634007483 ABC transporter signature motif; other site 1167634007484 Walker B; other site 1167634007485 D-loop; other site 1167634007486 H-loop/switch region; other site 1167634007487 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634007488 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634007489 TM-ABC transporter signature motif; other site 1167634007490 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634007491 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634007492 Walker A/P-loop; other site 1167634007493 ATP binding site [chemical binding]; other site 1167634007494 Q-loop/lid; other site 1167634007495 ABC transporter signature motif; other site 1167634007496 Walker B; other site 1167634007497 D-loop; other site 1167634007498 H-loop/switch region; other site 1167634007499 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634007500 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634007501 TM-ABC transporter signature motif; other site 1167634007502 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634007503 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 1167634007504 putative ligand binding site [chemical binding]; other site 1167634007505 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1167634007506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634007507 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1167634007508 dimerization interface [polypeptide binding]; other site 1167634007509 substrate binding pocket [chemical binding]; other site 1167634007510 LysE type translocator; Region: LysE; cl00565 1167634007511 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1167634007512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634007513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634007514 dimerization interface [polypeptide binding]; other site 1167634007515 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1167634007516 glutamate dehydrogenase; Provisional; Region: PRK09414 1167634007517 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1167634007518 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1167634007519 NAD(P) binding site [chemical binding]; other site 1167634007520 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1167634007521 putative active site [active] 1167634007522 putative catalytic site [active] 1167634007523 putative DNA binding site [nucleotide binding]; other site 1167634007524 putative phosphate binding site [ion binding]; other site 1167634007525 metal binding site A [ion binding]; metal-binding site 1167634007526 putative AP binding site [nucleotide binding]; other site 1167634007527 putative metal binding site B [ion binding]; other site 1167634007528 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1167634007529 active site 1167634007530 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1167634007531 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1167634007532 GatB domain; Region: GatB_Yqey; smart00845 1167634007533 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1167634007534 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1167634007535 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1167634007536 rod shape-determining protein MreB; Provisional; Region: PRK13927 1167634007537 MreB and similar proteins; Region: MreB_like; cd10225 1167634007538 nucleotide binding site [chemical binding]; other site 1167634007539 Mg binding site [ion binding]; other site 1167634007540 putative protofilament interaction site [polypeptide binding]; other site 1167634007541 RodZ interaction site [polypeptide binding]; other site 1167634007542 rod shape-determining protein MreC; Provisional; Region: PRK13922 1167634007543 rod shape-determining protein MreC; Region: MreC; pfam04085 1167634007544 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1167634007545 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1167634007546 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1167634007547 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1167634007548 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1167634007549 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1167634007550 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1167634007551 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1167634007552 transmembrane helices; other site 1167634007553 division inhibitor protein; Provisional; Region: slmA; PRK09480 1167634007554 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1167634007555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634007556 motif II; other site 1167634007557 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1167634007558 feedback inhibition sensing region; other site 1167634007559 homohexameric interface [polypeptide binding]; other site 1167634007560 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1167634007561 nucleotide binding site [chemical binding]; other site 1167634007562 N-acetyl-L-glutamate binding site [chemical binding]; other site 1167634007563 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1167634007564 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1167634007565 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1167634007566 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1167634007567 catalytic residues [active] 1167634007568 BON domain; Region: BON; pfam04972 1167634007569 BON domain; Region: BON; cl02771 1167634007570 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1167634007571 dimer interface [polypeptide binding]; other site 1167634007572 active site 1167634007573 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1167634007574 Predicted methyltransferases [General function prediction only]; Region: COG0313 1167634007575 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1167634007576 putative SAM binding site [chemical binding]; other site 1167634007577 putative homodimer interface [polypeptide binding]; other site 1167634007578 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1167634007579 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1167634007580 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1167634007581 DNA binding site [nucleotide binding] 1167634007582 active site 1167634007583 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1167634007584 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1167634007585 Sporulation related domain; Region: SPOR; pfam05036 1167634007586 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1167634007587 shikimate kinase; Reviewed; Region: aroK; PRK00131 1167634007588 Cytochrome c; Region: Cytochrom_C; cl11414 1167634007589 Cytochrome c; Region: Cytochrom_C; cl11414 1167634007590 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1167634007591 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1167634007592 Cytochrome c; Region: Cytochrom_C; pfam00034 1167634007593 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634007594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634007595 DNA-binding site [nucleotide binding]; DNA binding site 1167634007596 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634007597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634007598 homodimer interface [polypeptide binding]; other site 1167634007599 catalytic residue [active] 1167634007600 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1167634007601 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1167634007602 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1167634007603 Hpr binding site; other site 1167634007604 active site 1167634007605 homohexamer subunit interaction site [polypeptide binding]; other site 1167634007606 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1167634007607 active site 1167634007608 phosphorylation site [posttranslational modification] 1167634007609 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1167634007610 30S subunit binding site; other site 1167634007611 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1167634007612 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1167634007613 Walker A/P-loop; other site 1167634007614 ATP binding site [chemical binding]; other site 1167634007615 Q-loop/lid; other site 1167634007616 ABC transporter signature motif; other site 1167634007617 Walker B; other site 1167634007618 D-loop; other site 1167634007619 H-loop/switch region; other site 1167634007620 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1167634007621 OstA-like protein; Region: OstA; pfam03968 1167634007622 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1167634007623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 1167634007624 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1167634007625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634007626 active site 1167634007627 motif I; other site 1167634007628 motif II; other site 1167634007629 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1167634007630 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1167634007631 putative active site [active] 1167634007632 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1167634007633 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1167634007634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634007635 ATP-grasp domain; Region: ATP-grasp; pfam02222 1167634007636 Predicted transcriptional regulators [Transcription]; Region: COG1510 1167634007637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634007638 dimerization interface [polypeptide binding]; other site 1167634007639 putative DNA binding site [nucleotide binding]; other site 1167634007640 putative Zn2+ binding site [ion binding]; other site 1167634007641 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1167634007642 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1167634007643 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1167634007644 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1167634007645 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 1167634007646 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1167634007647 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634007648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634007649 Walker A/P-loop; other site 1167634007650 ATP binding site [chemical binding]; other site 1167634007651 Q-loop/lid; other site 1167634007652 ABC transporter signature motif; other site 1167634007653 Walker B; other site 1167634007654 D-loop; other site 1167634007655 H-loop/switch region; other site 1167634007656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634007657 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1167634007658 Walker A/P-loop; other site 1167634007659 ATP binding site [chemical binding]; other site 1167634007660 Q-loop/lid; other site 1167634007661 ABC transporter signature motif; other site 1167634007662 Walker B; other site 1167634007663 D-loop; other site 1167634007664 H-loop/switch region; other site 1167634007665 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1167634007666 active site 1167634007667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634007668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634007669 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634007670 putative effector binding pocket; other site 1167634007671 dimerization interface [polypeptide binding]; other site 1167634007672 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1167634007673 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1167634007674 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1167634007675 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1167634007676 trimer interface [polypeptide binding]; other site 1167634007677 eyelet of channel; other site 1167634007678 threonine dehydratase; Reviewed; Region: PRK09224 1167634007679 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1167634007680 tetramer interface [polypeptide binding]; other site 1167634007681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634007682 catalytic residue [active] 1167634007683 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1167634007684 putative Ile/Val binding site [chemical binding]; other site 1167634007685 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1167634007686 putative Ile/Val binding site [chemical binding]; other site 1167634007687 Predicted membrane protein [Function unknown]; Region: COG1238 1167634007688 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 1167634007689 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1167634007690 FAD binding domain; Region: FAD_binding_4; pfam01565 1167634007691 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1167634007692 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1167634007693 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1167634007694 Cysteine-rich domain; Region: CCG; pfam02754 1167634007695 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 1167634007696 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1167634007697 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634007698 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1167634007699 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1167634007700 catalytic residue [active] 1167634007701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634007702 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1167634007703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634007704 homodimer interface [polypeptide binding]; other site 1167634007705 catalytic residue [active] 1167634007706 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1167634007707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634007708 substrate binding pocket [chemical binding]; other site 1167634007709 membrane-bound complex binding site; other site 1167634007710 hinge residues; other site 1167634007711 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1167634007712 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1167634007713 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1167634007714 active site 1167634007715 catalytic residues [active] 1167634007716 metal binding site [ion binding]; metal-binding site 1167634007717 DNA protecting protein DprA; Region: dprA; TIGR00732 1167634007718 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1167634007719 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1167634007720 active site 1167634007721 catalytic residues [active] 1167634007722 metal binding site [ion binding]; metal-binding site 1167634007723 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1167634007724 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1167634007725 putative active site [active] 1167634007726 substrate binding site [chemical binding]; other site 1167634007727 putative cosubstrate binding site; other site 1167634007728 catalytic site [active] 1167634007729 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1167634007730 substrate binding site [chemical binding]; other site 1167634007731 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 1167634007732 putative active site [active] 1167634007733 putative metal binding residues [ion binding]; other site 1167634007734 signature motif; other site 1167634007735 putative triphosphate binding site [ion binding]; other site 1167634007736 dimer interface [polypeptide binding]; other site 1167634007737 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1167634007738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634007739 motif II; other site 1167634007740 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1167634007741 Ferritin-like domain; Region: Ferritin; pfam00210 1167634007742 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1167634007743 dinuclear metal binding motif [ion binding]; other site 1167634007744 Predicted transcriptional regulators [Transcription]; Region: COG1733 1167634007745 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1167634007746 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1167634007747 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1167634007748 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1167634007749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1167634007750 FeS/SAM binding site; other site 1167634007751 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634007752 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1167634007753 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1167634007754 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 1167634007755 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 1167634007756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634007757 dimerization interface [polypeptide binding]; other site 1167634007758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634007759 dimer interface [polypeptide binding]; other site 1167634007760 phosphorylation site [posttranslational modification] 1167634007761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634007762 ATP binding site [chemical binding]; other site 1167634007763 Mg2+ binding site [ion binding]; other site 1167634007764 G-X-G motif; other site 1167634007765 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634007766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634007767 active site 1167634007768 phosphorylation site [posttranslational modification] 1167634007769 intermolecular recognition site; other site 1167634007770 dimerization interface [polypeptide binding]; other site 1167634007771 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1167634007772 TrkA-N domain; Region: TrkA_N; pfam02254 1167634007773 TrkA-C domain; Region: TrkA_C; pfam02080 1167634007774 TrkA-N domain; Region: TrkA_N; pfam02254 1167634007775 TrkA-C domain; Region: TrkA_C; pfam02080 1167634007776 Cation transport protein; Region: TrkH; cl17365 1167634007777 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1167634007778 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1167634007779 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1167634007780 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1167634007781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634007782 S-adenosylmethionine binding site [chemical binding]; other site 1167634007783 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1167634007784 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1167634007785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634007786 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1167634007787 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1167634007788 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1167634007789 preprotein translocase subunit SecB; Validated; Region: PRK05751 1167634007790 SecA binding site; other site 1167634007791 Preprotein binding site; other site 1167634007792 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1167634007793 GSH binding site [chemical binding]; other site 1167634007794 catalytic residues [active] 1167634007795 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1167634007796 active site residue [active] 1167634007797 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1167634007798 catalytic core [active] 1167634007799 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1167634007800 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1167634007801 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1167634007802 Peptidase family M23; Region: Peptidase_M23; pfam01551 1167634007803 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1167634007804 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1167634007805 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1167634007806 protein binding site [polypeptide binding]; other site 1167634007807 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1167634007808 Catalytic dyad [active] 1167634007809 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1167634007810 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1167634007811 ATP binding site [chemical binding]; other site 1167634007812 substrate interface [chemical binding]; other site 1167634007813 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634007814 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634007815 metal binding site [ion binding]; metal-binding site 1167634007816 active site 1167634007817 I-site; other site 1167634007818 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1167634007819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634007820 DNA-binding site [nucleotide binding]; DNA binding site 1167634007821 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1167634007822 FAD binding domain; Region: FAD_binding_4; pfam01565 1167634007823 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1167634007824 ThiC-associated domain; Region: ThiC-associated; pfam13667 1167634007825 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1167634007826 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1167634007827 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634007828 gamma-glutamyl kinase; Provisional; Region: PRK05429 1167634007829 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1167634007830 nucleotide binding site [chemical binding]; other site 1167634007831 homotetrameric interface [polypeptide binding]; other site 1167634007832 putative phosphate binding site [ion binding]; other site 1167634007833 putative allosteric binding site; other site 1167634007834 PUA domain; Region: PUA; pfam01472 1167634007835 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1167634007836 GTP1/OBG; Region: GTP1_OBG; pfam01018 1167634007837 Obg GTPase; Region: Obg; cd01898 1167634007838 G1 box; other site 1167634007839 GTP/Mg2+ binding site [chemical binding]; other site 1167634007840 Switch I region; other site 1167634007841 G2 box; other site 1167634007842 G3 box; other site 1167634007843 Switch II region; other site 1167634007844 G4 box; other site 1167634007845 G5 box; other site 1167634007846 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1167634007847 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1167634007848 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1167634007849 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1167634007850 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1167634007851 substrate binding pocket [chemical binding]; other site 1167634007852 chain length determination region; other site 1167634007853 substrate-Mg2+ binding site; other site 1167634007854 catalytic residues [active] 1167634007855 aspartate-rich region 1; other site 1167634007856 active site lid residues [active] 1167634007857 aspartate-rich region 2; other site 1167634007858 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 1167634007859 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1167634007860 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1167634007861 nitrilase; Region: PLN02798 1167634007862 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1167634007863 putative active site [active] 1167634007864 catalytic triad [active] 1167634007865 dimer interface [polypeptide binding]; other site 1167634007866 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1167634007867 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1167634007868 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634007869 catalytic site [active] 1167634007870 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1167634007871 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634007872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634007873 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1167634007874 putative dimerization interface [polypeptide binding]; other site 1167634007875 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1167634007876 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1167634007877 NADP binding site [chemical binding]; other site 1167634007878 dimer interface [polypeptide binding]; other site 1167634007879 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1167634007880 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634007881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634007882 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1167634007883 dimerization interface [polypeptide binding]; other site 1167634007884 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1167634007885 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1167634007886 DNA binding residues [nucleotide binding] 1167634007887 putative dimer interface [polypeptide binding]; other site 1167634007888 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634007889 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1167634007890 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1167634007891 putative aldolase; Validated; Region: PRK08130 1167634007892 intersubunit interface [polypeptide binding]; other site 1167634007893 active site 1167634007894 Zn2+ binding site [ion binding]; other site 1167634007895 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1167634007896 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1167634007897 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1167634007898 putative NAD(P) binding site [chemical binding]; other site 1167634007899 active site 1167634007900 putative substrate binding site [chemical binding]; other site 1167634007901 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1167634007902 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1167634007903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1167634007904 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1167634007905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634007906 DNA-binding site [nucleotide binding]; DNA binding site 1167634007907 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1167634007908 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1167634007909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634007910 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634007911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634007912 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634007913 putative substrate translocation pore; other site 1167634007914 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 1167634007915 putative active site [active] 1167634007916 Zn binding site [ion binding]; other site 1167634007917 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1167634007918 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1167634007919 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1167634007920 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1167634007921 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634007922 threonine and homoserine efflux system; Provisional; Region: PRK10532 1167634007923 EamA-like transporter family; Region: EamA; pfam00892 1167634007924 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634007925 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634007926 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634007927 putative DNA binding site [nucleotide binding]; other site 1167634007928 putative Zn2+ binding site [ion binding]; other site 1167634007929 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634007930 LysE type translocator; Region: LysE; cl00565 1167634007931 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1167634007932 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1167634007933 inhibitor-cofactor binding pocket; inhibition site 1167634007934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634007935 catalytic residue [active] 1167634007936 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1167634007937 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1167634007938 tRNA; other site 1167634007939 putative tRNA binding site [nucleotide binding]; other site 1167634007940 putative NADP binding site [chemical binding]; other site 1167634007941 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1167634007942 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1167634007943 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1167634007944 RF-1 domain; Region: RF-1; pfam00472 1167634007945 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1167634007946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634007947 S-adenosylmethionine binding site [chemical binding]; other site 1167634007948 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1167634007949 putative GSH binding site [chemical binding]; other site 1167634007950 catalytic residues [active] 1167634007951 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1167634007952 Flavoprotein; Region: Flavoprotein; pfam02441 1167634007953 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1167634007954 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1167634007955 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1167634007956 Cupin domain; Region: Cupin_2; cl17218 1167634007957 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634007958 classical (c) SDRs; Region: SDR_c; cd05233 1167634007959 NAD(P) binding site [chemical binding]; other site 1167634007960 active site 1167634007961 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1167634007962 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1167634007963 active site 1167634007964 oxalacetate binding site [chemical binding]; other site 1167634007965 citrylCoA binding site [chemical binding]; other site 1167634007966 coenzyme A binding site [chemical binding]; other site 1167634007967 catalytic triad [active] 1167634007968 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1167634007969 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1167634007970 acyl-activating enzyme (AAE) consensus motif; other site 1167634007971 putative AMP binding site [chemical binding]; other site 1167634007972 putative active site [active] 1167634007973 putative CoA binding site [chemical binding]; other site 1167634007974 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634007975 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634007976 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634007977 putative DNA binding site [nucleotide binding]; other site 1167634007978 putative Zn2+ binding site [ion binding]; other site 1167634007979 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1167634007980 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1167634007981 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1167634007982 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1167634007983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634007984 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634007985 putative substrate translocation pore; other site 1167634007986 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634007987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634007988 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634007989 dimerization interface [polypeptide binding]; other site 1167634007990 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1167634007991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634007992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634007993 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634007994 dimerization interface [polypeptide binding]; other site 1167634007995 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 1167634007996 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1167634007997 dimer interface [polypeptide binding]; other site 1167634007998 active site 1167634007999 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1167634008000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1167634008001 active site 1167634008002 FAD dependent oxidoreductase; Region: DAO; pfam01266 1167634008003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634008004 NAD(P) binding site [chemical binding]; other site 1167634008005 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1167634008006 active site 1167634008007 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1167634008008 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1167634008009 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1167634008010 Ligand binding site; other site 1167634008011 Putative Catalytic site; other site 1167634008012 DXD motif; other site 1167634008013 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634008014 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1167634008015 putative C-terminal domain interface [polypeptide binding]; other site 1167634008016 putative GSH binding site (G-site) [chemical binding]; other site 1167634008017 putative dimer interface [polypeptide binding]; other site 1167634008018 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1167634008019 dimer interface [polypeptide binding]; other site 1167634008020 N-terminal domain interface [polypeptide binding]; other site 1167634008021 putative substrate binding pocket (H-site) [chemical binding]; other site 1167634008022 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 1167634008023 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634008024 classical (c) SDRs; Region: SDR_c; cd05233 1167634008025 NAD(P) binding site [chemical binding]; other site 1167634008026 active site 1167634008027 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634008028 classical (c) SDRs; Region: SDR_c; cd05233 1167634008029 NAD(P) binding site [chemical binding]; other site 1167634008030 active site 1167634008031 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634008032 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634008033 Walker A/P-loop; other site 1167634008034 ATP binding site [chemical binding]; other site 1167634008035 Q-loop/lid; other site 1167634008036 ABC transporter signature motif; other site 1167634008037 Walker B; other site 1167634008038 D-loop; other site 1167634008039 H-loop/switch region; other site 1167634008040 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634008041 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634008042 Walker A/P-loop; other site 1167634008043 ATP binding site [chemical binding]; other site 1167634008044 Q-loop/lid; other site 1167634008045 ABC transporter signature motif; other site 1167634008046 Walker B; other site 1167634008047 D-loop; other site 1167634008048 H-loop/switch region; other site 1167634008049 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634008050 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634008051 TM-ABC transporter signature motif; other site 1167634008052 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634008053 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634008054 TM-ABC transporter signature motif; other site 1167634008055 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1167634008056 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634008057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634008058 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634008059 NAD(P) binding site [chemical binding]; other site 1167634008060 active site 1167634008061 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634008062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634008063 DNA-binding site [nucleotide binding]; DNA binding site 1167634008064 FCD domain; Region: FCD; pfam07729 1167634008065 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1167634008066 active site clefts [active] 1167634008067 zinc binding site [ion binding]; other site 1167634008068 dimer interface [polypeptide binding]; other site 1167634008069 psiF repeat; Region: PsiF_repeat; pfam07769 1167634008070 psiF repeat; Region: PsiF_repeat; pfam07769 1167634008071 Putative cyclase; Region: Cyclase; pfam04199 1167634008072 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1167634008073 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1167634008074 YciI-like protein; Reviewed; Region: PRK12863 1167634008075 Muconolactone delta-isomerase; Region: MIase; cl01992 1167634008076 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1167634008077 Coenzyme A transferase; Region: CoA_trans; cl17247 1167634008078 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1167634008079 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1167634008080 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634008081 short chain dehydrogenase; Provisional; Region: PRK07577 1167634008082 classical (c) SDRs; Region: SDR_c; cd05233 1167634008083 NAD(P) binding site [chemical binding]; other site 1167634008084 active site 1167634008085 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1167634008086 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 1167634008087 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1167634008088 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634008089 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1167634008090 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1167634008091 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1167634008092 Ligand Binding Site [chemical binding]; other site 1167634008093 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1167634008094 DNA binding site [nucleotide binding] 1167634008095 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634008096 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1167634008097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634008098 Coenzyme A binding pocket [chemical binding]; other site 1167634008099 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1167634008100 active site 1167634008101 catalytic residues [active] 1167634008102 metal binding site [ion binding]; metal-binding site 1167634008103 Helix-turn-helix domain; Region: HTH_18; pfam12833 1167634008104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634008105 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1167634008106 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634008107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634008108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634008109 dimerization interface [polypeptide binding]; other site 1167634008110 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1167634008111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634008112 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1167634008113 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 1167634008114 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1167634008115 E3 interaction surface; other site 1167634008116 lipoyl attachment site [posttranslational modification]; other site 1167634008117 e3 binding domain; Region: E3_binding; pfam02817 1167634008118 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1167634008119 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1167634008120 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634008121 active site 1167634008122 Pyruvate dehydrogenase E1 component subunit alpha; Region: PLN02269 1167634008123 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1167634008124 tetramer interface [polypeptide binding]; other site 1167634008125 TPP-binding site [chemical binding]; other site 1167634008126 heterodimer interface [polypeptide binding]; other site 1167634008127 phosphorylation loop region [posttranslational modification] 1167634008128 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1167634008129 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1167634008130 alpha subunit interface [polypeptide binding]; other site 1167634008131 TPP binding site [chemical binding]; other site 1167634008132 heterodimer interface [polypeptide binding]; other site 1167634008133 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1167634008134 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1167634008135 classical (c) SDRs; Region: SDR_c; cd05233 1167634008136 NAD(P) binding site [chemical binding]; other site 1167634008137 active site 1167634008138 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634008139 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634008140 Walker A/P-loop; other site 1167634008141 ATP binding site [chemical binding]; other site 1167634008142 Q-loop/lid; other site 1167634008143 ABC transporter signature motif; other site 1167634008144 Walker B; other site 1167634008145 D-loop; other site 1167634008146 H-loop/switch region; other site 1167634008147 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634008148 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634008149 Walker A/P-loop; other site 1167634008150 ATP binding site [chemical binding]; other site 1167634008151 Q-loop/lid; other site 1167634008152 ABC transporter signature motif; other site 1167634008153 Walker B; other site 1167634008154 D-loop; other site 1167634008155 H-loop/switch region; other site 1167634008156 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634008157 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634008158 TM-ABC transporter signature motif; other site 1167634008159 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634008160 TM-ABC transporter signature motif; other site 1167634008161 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634008162 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 1167634008163 putative ligand binding site [chemical binding]; other site 1167634008164 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1167634008165 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1167634008166 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1167634008167 shikimate binding site; other site 1167634008168 NAD(P) binding site [chemical binding]; other site 1167634008169 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634008170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634008171 NAD(P) binding site [chemical binding]; other site 1167634008172 active site 1167634008173 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1167634008174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634008175 DNA-binding site [nucleotide binding]; DNA binding site 1167634008176 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1167634008177 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1167634008178 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1167634008179 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1167634008180 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1167634008181 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1167634008182 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1167634008183 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1167634008184 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1167634008185 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1167634008186 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634008187 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634008188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634008189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634008190 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1167634008191 putative effector binding pocket; other site 1167634008192 putative dimerization interface [polypeptide binding]; other site 1167634008193 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1167634008194 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1167634008195 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1167634008196 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1167634008197 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1167634008198 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634008199 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1167634008200 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1167634008201 inhibitor site; inhibition site 1167634008202 active site 1167634008203 dimer interface [polypeptide binding]; other site 1167634008204 catalytic residue [active] 1167634008205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634008206 dimer interface [polypeptide binding]; other site 1167634008207 conserved gate region; other site 1167634008208 putative PBP binding loops; other site 1167634008209 ABC-ATPase subunit interface; other site 1167634008210 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1167634008211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634008212 dimer interface [polypeptide binding]; other site 1167634008213 conserved gate region; other site 1167634008214 putative PBP binding loops; other site 1167634008215 ABC-ATPase subunit interface; other site 1167634008216 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1167634008217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634008218 Walker A/P-loop; other site 1167634008219 ATP binding site [chemical binding]; other site 1167634008220 Q-loop/lid; other site 1167634008221 ABC transporter signature motif; other site 1167634008222 Walker B; other site 1167634008223 D-loop; other site 1167634008224 H-loop/switch region; other site 1167634008225 TOBE domain; Region: TOBE_2; pfam08402 1167634008226 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1167634008227 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1167634008228 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1167634008229 FAD binding domain; Region: FAD_binding_4; pfam01565 1167634008230 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1167634008231 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1167634008232 phosphate binding site [ion binding]; other site 1167634008233 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1167634008234 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1167634008235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634008236 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1167634008237 putative substrate translocation pore; other site 1167634008238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634008239 salt bridge; other site 1167634008240 non-specific DNA binding site [nucleotide binding]; other site 1167634008241 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1167634008242 sequence-specific DNA binding site [nucleotide binding]; other site 1167634008243 EamA-like transporter family; Region: EamA; pfam00892 1167634008244 Predicted transcriptional regulators [Transcription]; Region: COG1695 1167634008245 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1167634008246 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1167634008247 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1167634008248 FAD binding pocket [chemical binding]; other site 1167634008249 FAD binding motif [chemical binding]; other site 1167634008250 phosphate binding motif [ion binding]; other site 1167634008251 NAD binding pocket [chemical binding]; other site 1167634008252 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634008253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634008254 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1167634008255 putative dimerization interface [polypeptide binding]; other site 1167634008256 putative substrate binding pocket [chemical binding]; other site 1167634008257 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1167634008258 tetramer interface [polypeptide binding]; other site 1167634008259 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1167634008260 active site 1167634008261 Mg2+/Mn2+ binding site [ion binding]; other site 1167634008262 KWG Leptospira; Region: KWG; pfam07656 1167634008263 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634008264 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1167634008265 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1167634008266 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634008267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634008268 active site 1167634008269 phosphorylation site [posttranslational modification] 1167634008270 intermolecular recognition site; other site 1167634008271 dimerization interface [polypeptide binding]; other site 1167634008272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634008273 DNA binding residues [nucleotide binding] 1167634008274 dimerization interface [polypeptide binding]; other site 1167634008275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634008276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634008277 dimer interface [polypeptide binding]; other site 1167634008278 phosphorylation site [posttranslational modification] 1167634008279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634008280 ATP binding site [chemical binding]; other site 1167634008281 Mg2+ binding site [ion binding]; other site 1167634008282 G-X-G motif; other site 1167634008283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634008284 putative substrate translocation pore; other site 1167634008285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634008286 Cupin domain; Region: Cupin_2; cl17218 1167634008287 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1167634008288 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1167634008289 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 1167634008290 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1167634008291 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1167634008292 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1167634008293 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1167634008294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634008295 non-specific DNA binding site [nucleotide binding]; other site 1167634008296 salt bridge; other site 1167634008297 sequence-specific DNA binding site [nucleotide binding]; other site 1167634008298 Predicted transcriptional regulator [Transcription]; Region: COG2932 1167634008299 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1167634008300 Catalytic site [active] 1167634008301 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 1167634008302 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 1167634008303 Phage minor tail protein; Region: Phage_min_tail; cl01940 1167634008304 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1167634008305 Phage-related protein [Function unknown]; Region: gp18; COG4672 1167634008306 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1167634008307 MPN+ (JAMM) motif; other site 1167634008308 Zinc-binding site [ion binding]; other site 1167634008309 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1167634008310 NlpC/P60 family; Region: NLPC_P60; cl17555 1167634008311 Phage-related protein, tail component [Function unknown]; Region: COG4723 1167634008312 Phage-related protein, tail component [Function unknown]; Region: COG4733 1167634008313 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1167634008314 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1167634008315 Phage-related protein, tail component [Function unknown]; Region: COG4723 1167634008316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634008317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634008318 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634008319 short chain dehydrogenase; Provisional; Region: PRK12829 1167634008320 classical (c) SDRs; Region: SDR_c; cd05233 1167634008321 NAD(P) binding site [chemical binding]; other site 1167634008322 active site 1167634008323 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634008324 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1167634008325 putative ligand binding site [chemical binding]; other site 1167634008326 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1167634008327 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1167634008328 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1167634008329 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634008330 substrate binding pocket [chemical binding]; other site 1167634008331 membrane-bound complex binding site; other site 1167634008332 hinge residues; other site 1167634008333 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1167634008334 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1167634008335 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 1167634008336 Type IV secretion system proteins; Region: T4SS; pfam07996 1167634008337 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 1167634008338 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1167634008339 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634008340 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634008341 DNA-binding site [nucleotide binding]; DNA binding site 1167634008342 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634008343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634008344 homodimer interface [polypeptide binding]; other site 1167634008345 catalytic residue [active] 1167634008346 integrase; Provisional; Region: int; PHA02601 1167634008347 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1167634008348 active site 1167634008349 DNA binding site [nucleotide binding] 1167634008350 Int/Topo IB signature motif; other site 1167634008351 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1167634008352 DKNYY family; Region: DKNYY; pfam13644 1167634008353 heat shock protein 90; Provisional; Region: PRK05218 1167634008354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634008355 ATP binding site [chemical binding]; other site 1167634008356 Mg2+ binding site [ion binding]; other site 1167634008357 G-X-G motif; other site 1167634008358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634008359 non-specific DNA binding site [nucleotide binding]; other site 1167634008360 salt bridge; other site 1167634008361 sequence-specific DNA binding site [nucleotide binding]; other site 1167634008362 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1167634008363 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1167634008364 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1167634008365 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1167634008366 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1167634008367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634008368 putative substrate translocation pore; other site 1167634008369 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1167634008370 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634008371 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634008372 N-terminal plug; other site 1167634008373 ligand-binding site [chemical binding]; other site 1167634008374 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 1167634008375 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1167634008376 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1167634008377 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 1167634008378 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1167634008379 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1167634008380 Walker A/P-loop; other site 1167634008381 ATP binding site [chemical binding]; other site 1167634008382 Q-loop/lid; other site 1167634008383 ABC transporter signature motif; other site 1167634008384 Walker B; other site 1167634008385 D-loop; other site 1167634008386 H-loop/switch region; other site 1167634008387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634008388 D-galactonate transporter; Region: 2A0114; TIGR00893 1167634008389 putative substrate translocation pore; other site 1167634008390 galactonate dehydratase; Provisional; Region: PRK14017 1167634008391 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1167634008392 putative active site pocket [active] 1167634008393 putative metal binding site [ion binding]; other site 1167634008394 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1167634008395 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1167634008396 active site 1167634008397 intersubunit interface [polypeptide binding]; other site 1167634008398 catalytic residue [active] 1167634008399 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1167634008400 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634008401 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1167634008402 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634008403 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1167634008404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634008405 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1167634008406 DNA binding residues [nucleotide binding] 1167634008407 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634008408 FecR protein; Region: FecR; pfam04773 1167634008409 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1167634008410 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1167634008411 Heme-binding protein A (HasA); Region: HasA; pfam06438 1167634008412 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1167634008413 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634008414 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1167634008415 Walker A/P-loop; other site 1167634008416 ATP binding site [chemical binding]; other site 1167634008417 Q-loop/lid; other site 1167634008418 ABC transporter signature motif; other site 1167634008419 Walker B; other site 1167634008420 D-loop; other site 1167634008421 H-loop/switch region; other site 1167634008422 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1167634008423 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634008424 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634008425 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1167634008426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634008427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634008428 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1167634008429 putative dimerization interface [polypeptide binding]; other site 1167634008430 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1167634008431 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1167634008432 NAD(P) binding site [chemical binding]; other site 1167634008433 catalytic residues [active] 1167634008434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634008435 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1167634008436 NAD(P) binding site [chemical binding]; other site 1167634008437 active site 1167634008438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634008439 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634008440 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1167634008441 putative C-terminal domain interface [polypeptide binding]; other site 1167634008442 putative GSH binding site (G-site) [chemical binding]; other site 1167634008443 putative dimer interface [polypeptide binding]; other site 1167634008444 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1167634008445 putative N-terminal domain interface [polypeptide binding]; other site 1167634008446 putative dimer interface [polypeptide binding]; other site 1167634008447 putative substrate binding pocket (H-site) [chemical binding]; other site 1167634008448 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1167634008449 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1167634008450 substrate binding site [chemical binding]; other site 1167634008451 amidase catalytic site [active] 1167634008452 Zn binding residues [ion binding]; other site 1167634008453 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1167634008454 signal recognition particle protein; Provisional; Region: PRK10867 1167634008455 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1167634008456 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1167634008457 GTP binding site [chemical binding]; other site 1167634008458 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1167634008459 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1167634008460 BON domain; Region: BON; pfam04972 1167634008461 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1167634008462 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1167634008463 thiS-thiF/thiG interaction site; other site 1167634008464 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1167634008465 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1167634008466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634008467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634008468 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1167634008469 putative dimerization interface [polypeptide binding]; other site 1167634008470 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634008471 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634008472 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1167634008473 active site 1167634008474 catalytic residues [active] 1167634008475 metal binding site [ion binding]; metal-binding site 1167634008476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634008477 Protein of unknown function DUF72; Region: DUF72; pfam01904 1167634008478 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634008479 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1167634008480 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1167634008481 active site pocket [active] 1167634008482 Helix-turn-helix domain; Region: HTH_17; pfam12728 1167634008483 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 1167634008484 dimer interface [polypeptide binding]; other site 1167634008485 active site 1167634008486 oxalacetate/citrate binding site [chemical binding]; other site 1167634008487 citrylCoA binding site [chemical binding]; other site 1167634008488 coenzyme A binding site [chemical binding]; other site 1167634008489 catalytic triad [active] 1167634008490 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1167634008491 Amidase; Region: Amidase; cl11426 1167634008492 hypothetical protein; Validated; Region: PRK06201 1167634008493 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1167634008494 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464 1167634008495 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1167634008496 FeS/SAM binding site; other site 1167634008497 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1167634008498 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1167634008499 ligand binding site [chemical binding]; other site 1167634008500 flexible hinge region; other site 1167634008501 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1167634008502 non-specific DNA interactions [nucleotide binding]; other site 1167634008503 DNA binding site [nucleotide binding] 1167634008504 sequence specific DNA binding site [nucleotide binding]; other site 1167634008505 putative cAMP binding site [chemical binding]; other site 1167634008506 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634008507 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1167634008508 putative ligand binding site [chemical binding]; other site 1167634008509 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1167634008510 short chain dehydrogenase; Provisional; Region: PRK12829 1167634008511 classical (c) SDRs; Region: SDR_c; cd05233 1167634008512 NAD(P) binding site [chemical binding]; other site 1167634008513 active site 1167634008514 fumarate hydratase FumA; Provisional; Region: PRK15390 1167634008515 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1167634008516 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1167634008517 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634008518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634008519 putative substrate translocation pore; other site 1167634008520 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1167634008521 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1167634008522 C-terminal domain interface [polypeptide binding]; other site 1167634008523 GSH binding site (G-site) [chemical binding]; other site 1167634008524 putative dimer interface [polypeptide binding]; other site 1167634008525 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1167634008526 substrate binding pocket (H-site) [chemical binding]; other site 1167634008527 N-terminal domain interface [polypeptide binding]; other site 1167634008528 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1167634008529 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1167634008530 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1167634008531 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1167634008532 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1167634008533 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634008534 Zn binding site [ion binding]; other site 1167634008535 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 1167634008536 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634008537 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634008538 DNA binding residues [nucleotide binding] 1167634008539 dimerization interface [polypeptide binding]; other site 1167634008540 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1167634008541 dimerization interface [polypeptide binding]; other site 1167634008542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634008543 dimer interface [polypeptide binding]; other site 1167634008544 phosphorylation site [posttranslational modification] 1167634008545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634008546 ATP binding site [chemical binding]; other site 1167634008547 Mg2+ binding site [ion binding]; other site 1167634008548 G-X-G motif; other site 1167634008549 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1167634008550 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 1167634008551 active sites [active] 1167634008552 tetramer interface [polypeptide binding]; other site 1167634008553 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634008554 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634008555 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634008556 N-terminal plug; other site 1167634008557 ligand-binding site [chemical binding]; other site 1167634008558 fec operon regulator FecR; Reviewed; Region: PRK09774 1167634008559 FecR protein; Region: FecR; pfam04773 1167634008560 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1167634008561 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634008562 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634008563 DNA binding residues [nucleotide binding] 1167634008564 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1167634008565 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1167634008566 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1167634008567 substrate binding site [chemical binding]; other site 1167634008568 ligand binding site [chemical binding]; other site 1167634008569 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1167634008570 substrate binding site [chemical binding]; other site 1167634008571 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634008572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634008573 DNA-binding site [nucleotide binding]; DNA binding site 1167634008574 FCD domain; Region: FCD; pfam07729 1167634008575 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1167634008576 allantoate amidohydrolase; Reviewed; Region: PRK12890 1167634008577 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1167634008578 active site 1167634008579 metal binding site [ion binding]; metal-binding site 1167634008580 dimer interface [polypeptide binding]; other site 1167634008581 allantoinase; Provisional; Region: PRK06189 1167634008582 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634008583 active site 1167634008584 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1167634008585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634008586 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1167634008587 putative dimerization interface [polypeptide binding]; other site 1167634008588 Protein of unknown function (DUF917); Region: DUF917; pfam06032 1167634008589 urocanate hydratase; Provisional; Region: PRK05414 1167634008590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634008591 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634008592 putative substrate translocation pore; other site 1167634008593 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1167634008594 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1167634008595 active sites [active] 1167634008596 tetramer interface [polypeptide binding]; other site 1167634008597 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634008598 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1167634008599 C-terminal domain interface [polypeptide binding]; other site 1167634008600 GSH binding site (G-site) [chemical binding]; other site 1167634008601 dimer interface [polypeptide binding]; other site 1167634008602 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1167634008603 dimer interface [polypeptide binding]; other site 1167634008604 N-terminal domain interface [polypeptide binding]; other site 1167634008605 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1167634008606 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1167634008607 Cytochrome c; Region: Cytochrom_C; pfam00034 1167634008608 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1167634008609 Cytochrome c; Region: Cytochrom_C; pfam00034 1167634008610 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634008611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634008612 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1167634008613 putative dimerization interface [polypeptide binding]; other site 1167634008614 tricarballylate dehydrogenase; Validated; Region: PRK08274 1167634008615 tricarballylate utilization protein B; Provisional; Region: PRK15033 1167634008616 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634008617 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634008618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634008619 DNA-binding site [nucleotide binding]; DNA binding site 1167634008620 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634008621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634008622 homodimer interface [polypeptide binding]; other site 1167634008623 catalytic residue [active] 1167634008624 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1167634008625 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1167634008626 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1167634008627 Serine hydrolase; Region: Ser_hydrolase; cl17834 1167634008628 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634008629 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1167634008630 EamA-like transporter family; Region: EamA; pfam00892 1167634008631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634008632 LysR family transcriptional regulator; Provisional; Region: PRK14997 1167634008633 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634008634 putative effector binding pocket; other site 1167634008635 dimerization interface [polypeptide binding]; other site 1167634008636 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1167634008637 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1167634008638 NAD(P) binding site [chemical binding]; other site 1167634008639 homotetramer interface [polypeptide binding]; other site 1167634008640 homodimer interface [polypeptide binding]; other site 1167634008641 active site 1167634008642 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1167634008643 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1167634008644 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1167634008645 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1167634008646 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1167634008647 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1167634008648 Walker A/P-loop; other site 1167634008649 ATP binding site [chemical binding]; other site 1167634008650 Q-loop/lid; other site 1167634008651 ABC transporter signature motif; other site 1167634008652 Walker B; other site 1167634008653 D-loop; other site 1167634008654 H-loop/switch region; other site 1167634008655 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1167634008656 Walker A/P-loop; other site 1167634008657 ATP binding site [chemical binding]; other site 1167634008658 Q-loop/lid; other site 1167634008659 ABC transporter signature motif; other site 1167634008660 Walker B; other site 1167634008661 D-loop; other site 1167634008662 H-loop/switch region; other site 1167634008663 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1167634008664 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1167634008665 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634008666 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634008667 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1167634008668 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1167634008669 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1167634008670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634008671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634008672 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1167634008673 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634008674 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 1167634008675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634008676 non-specific DNA binding site [nucleotide binding]; other site 1167634008677 salt bridge; other site 1167634008678 sequence-specific DNA binding site [nucleotide binding]; other site 1167634008679 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1167634008680 voltage-gated potassium channel; Provisional; Region: PRK10537 1167634008681 Ion channel; Region: Ion_trans_2; pfam07885 1167634008682 TrkA-N domain; Region: TrkA_N; pfam02254 1167634008683 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634008684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1167634008685 active site 1167634008686 phosphorylation site [posttranslational modification] 1167634008687 intermolecular recognition site; other site 1167634008688 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1167634008689 DNA binding site [nucleotide binding] 1167634008690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634008691 sequence-specific DNA binding site [nucleotide binding]; other site 1167634008692 salt bridge; other site 1167634008693 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1167634008694 META domain; Region: META; pfam03724 1167634008695 META domain; Region: META; pfam03724 1167634008696 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 1167634008697 rhodanese superfamily protein; Provisional; Region: PRK05320 1167634008698 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1167634008699 active site residue [active] 1167634008700 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1167634008701 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1167634008702 active site 1167634008703 HIGH motif; other site 1167634008704 KMSKS motif; other site 1167634008705 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1167634008706 tRNA binding surface [nucleotide binding]; other site 1167634008707 anticodon binding site; other site 1167634008708 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1167634008709 dimer interface [polypeptide binding]; other site 1167634008710 putative tRNA-binding site [nucleotide binding]; other site 1167634008711 Domain of unknown function DUF59; Region: DUF59; pfam01883 1167634008712 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1167634008713 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1167634008714 Walker A motif; other site 1167634008715 Surface antigen; Region: Bac_surface_Ag; pfam01103 1167634008716 Family of unknown function (DUF490); Region: DUF490; pfam04357 1167634008717 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1167634008718 trimer interface [polypeptide binding]; other site 1167634008719 active site 1167634008720 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1167634008721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634008722 active site 1167634008723 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634008724 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634008725 metal binding site [ion binding]; metal-binding site 1167634008726 active site 1167634008727 I-site; other site 1167634008728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1167634008729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634008730 Coenzyme A binding pocket [chemical binding]; other site 1167634008731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1167634008732 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1167634008733 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1167634008734 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1167634008735 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634008736 catalytic residue [active] 1167634008737 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1167634008738 Predicted flavoproteins [General function prediction only]; Region: COG2081 1167634008739 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1167634008740 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1167634008741 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1167634008742 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1167634008743 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1167634008744 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1167634008745 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1167634008746 lipoyl attachment site [posttranslational modification]; other site 1167634008747 glycine dehydrogenase; Provisional; Region: PRK05367 1167634008748 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1167634008749 tetramer interface [polypeptide binding]; other site 1167634008750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634008751 catalytic residue [active] 1167634008752 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1167634008753 tetramer interface [polypeptide binding]; other site 1167634008754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634008755 catalytic residue [active] 1167634008756 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1167634008757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1167634008758 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1167634008759 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1167634008760 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1167634008761 MlrC C-terminus; Region: MlrC_C; pfam07171 1167634008762 amidase; Provisional; Region: PRK07042 1167634008763 Amidase; Region: Amidase; cl11426 1167634008764 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1167634008765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634008766 Walker A/P-loop; other site 1167634008767 ATP binding site [chemical binding]; other site 1167634008768 Q-loop/lid; other site 1167634008769 ABC transporter signature motif; other site 1167634008770 Walker B; other site 1167634008771 D-loop; other site 1167634008772 H-loop/switch region; other site 1167634008773 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634008774 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634008775 Walker A/P-loop; other site 1167634008776 ATP binding site [chemical binding]; other site 1167634008777 Q-loop/lid; other site 1167634008778 ABC transporter signature motif; other site 1167634008779 Walker B; other site 1167634008780 D-loop; other site 1167634008781 H-loop/switch region; other site 1167634008782 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634008783 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1167634008784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634008785 dimer interface [polypeptide binding]; other site 1167634008786 conserved gate region; other site 1167634008787 putative PBP binding loops; other site 1167634008788 ABC-ATPase subunit interface; other site 1167634008789 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634008790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634008791 dimer interface [polypeptide binding]; other site 1167634008792 conserved gate region; other site 1167634008793 putative PBP binding loops; other site 1167634008794 ABC-ATPase subunit interface; other site 1167634008795 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1167634008796 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1167634008797 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1167634008798 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1167634008799 MlrC C-terminus; Region: MlrC_C; pfam07171 1167634008800 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1167634008801 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1167634008802 tetrameric interface [polypeptide binding]; other site 1167634008803 NAD binding site [chemical binding]; other site 1167634008804 catalytic residues [active] 1167634008805 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1167634008806 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1167634008807 inhibitor-cofactor binding pocket; inhibition site 1167634008808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634008809 catalytic residue [active] 1167634008810 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634008811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634008812 DNA-binding site [nucleotide binding]; DNA binding site 1167634008813 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634008814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634008815 homodimer interface [polypeptide binding]; other site 1167634008816 catalytic residue [active] 1167634008817 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1167634008818 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1167634008819 folate binding site [chemical binding]; other site 1167634008820 NADP+ binding site [chemical binding]; other site 1167634008821 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1167634008822 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1167634008823 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634008824 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634008825 metal binding site [ion binding]; metal-binding site 1167634008826 active site 1167634008827 I-site; other site 1167634008828 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634008829 thymidylate synthase; Provisional; Region: thyA; PRK13821 1167634008830 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1167634008831 dimerization interface [polypeptide binding]; other site 1167634008832 active site 1167634008833 OsmC-like protein; Region: OsmC; cl00767 1167634008834 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1167634008835 diiron binding motif [ion binding]; other site 1167634008836 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 1167634008837 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1167634008838 Mg++ binding site [ion binding]; other site 1167634008839 putative catalytic motif [active] 1167634008840 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1167634008841 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1167634008842 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1167634008843 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 1167634008844 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 1167634008845 NAD binding site [chemical binding]; other site 1167634008846 substrate binding site [chemical binding]; other site 1167634008847 homodimer interface [polypeptide binding]; other site 1167634008848 active site 1167634008849 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1167634008850 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634008851 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1167634008852 putative ADP-binding pocket [chemical binding]; other site 1167634008853 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1167634008854 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1167634008855 active site 1167634008856 dimer interface [polypeptide binding]; other site 1167634008857 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1167634008858 Ligand Binding Site [chemical binding]; other site 1167634008859 Molecular Tunnel; other site 1167634008860 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634008861 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1167634008862 putative ADP-binding pocket [chemical binding]; other site 1167634008863 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1167634008864 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1167634008865 putative ADP-binding pocket [chemical binding]; other site 1167634008866 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1167634008867 putative ADP-binding pocket [chemical binding]; other site 1167634008868 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634008869 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1167634008870 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1167634008871 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1167634008872 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1167634008873 active site 1167634008874 dimer interface [polypeptide binding]; other site 1167634008875 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1167634008876 dimer interface [polypeptide binding]; other site 1167634008877 active site 1167634008878 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1167634008879 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1167634008880 active site 1167634008881 substrate binding site [chemical binding]; other site 1167634008882 metal binding site [ion binding]; metal-binding site 1167634008883 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1167634008884 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1167634008885 FAD binding domain; Region: FAD_binding_4; pfam01565 1167634008886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634008887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634008888 active site 1167634008889 phosphorylation site [posttranslational modification] 1167634008890 intermolecular recognition site; other site 1167634008891 dimerization interface [polypeptide binding]; other site 1167634008892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634008893 DNA binding site [nucleotide binding] 1167634008894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634008895 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1167634008896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634008897 dimer interface [polypeptide binding]; other site 1167634008898 phosphorylation site [posttranslational modification] 1167634008899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634008900 ATP binding site [chemical binding]; other site 1167634008901 Mg2+ binding site [ion binding]; other site 1167634008902 G-X-G motif; other site 1167634008903 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1167634008904 active site 1167634008905 DctM-like transporters; Region: DctM; pfam06808 1167634008906 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1167634008907 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1167634008908 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1167634008909 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1167634008910 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1167634008911 Strictosidine synthase; Region: Str_synth; pfam03088 1167634008912 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1167634008913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634008914 NAD(P) binding site [chemical binding]; other site 1167634008915 active site 1167634008916 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1167634008917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634008918 DNA-binding site [nucleotide binding]; DNA binding site 1167634008919 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1167634008920 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1167634008921 Sulfatase; Region: Sulfatase; pfam00884 1167634008922 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1167634008923 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1167634008924 putative acyl-acceptor binding pocket; other site 1167634008925 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1167634008926 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1167634008927 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1167634008928 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1167634008929 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1167634008930 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634008931 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1167634008932 substrate binding pocket [chemical binding]; other site 1167634008933 dimerization interface [polypeptide binding]; other site 1167634008934 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 1167634008935 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 1167634008936 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634008937 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1167634008938 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1167634008939 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1167634008940 DNA binding site [nucleotide binding] 1167634008941 putative catalytic residues [active] 1167634008942 turnover-facilitating residue; other site 1167634008943 intercalation triad [nucleotide binding]; other site 1167634008944 8OG recognition residue [nucleotide binding]; other site 1167634008945 putative reading head residues; other site 1167634008946 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1167634008947 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1167634008948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1167634008949 TPR motif; other site 1167634008950 TPR repeat; Region: TPR_11; pfam13414 1167634008951 binding surface 1167634008952 TPR repeat; Region: TPR_11; pfam13414 1167634008953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1167634008954 binding surface 1167634008955 TPR motif; other site 1167634008956 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1167634008957 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1167634008958 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1167634008959 dimer interface [polypeptide binding]; other site 1167634008960 ligand binding site [chemical binding]; other site 1167634008961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634008962 dimerization interface [polypeptide binding]; other site 1167634008963 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634008964 dimer interface [polypeptide binding]; other site 1167634008965 putative CheW interface [polypeptide binding]; other site 1167634008966 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1167634008967 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1167634008968 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1167634008969 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1167634008970 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1167634008971 active site 1167634008972 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1167634008973 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1167634008974 5S rRNA interface [nucleotide binding]; other site 1167634008975 CTC domain interface [polypeptide binding]; other site 1167634008976 L16 interface [polypeptide binding]; other site 1167634008977 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1167634008978 putative active site [active] 1167634008979 catalytic residue [active] 1167634008980 GTP-binding protein YchF; Reviewed; Region: PRK09601 1167634008981 YchF GTPase; Region: YchF; cd01900 1167634008982 G1 box; other site 1167634008983 GTP/Mg2+ binding site [chemical binding]; other site 1167634008984 Switch I region; other site 1167634008985 G2 box; other site 1167634008986 Switch II region; other site 1167634008987 G3 box; other site 1167634008988 G4 box; other site 1167634008989 G5 box; other site 1167634008990 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1167634008991 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1167634008992 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1167634008993 active site 1167634008994 Int/Topo IB signature motif; other site 1167634008995 Fic family protein [Function unknown]; Region: COG3177 1167634008996 Fic/DOC family; Region: Fic; pfam02661 1167634008997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1167634008998 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 1167634008999 DNA methylase; Region: N6_N4_Mtase; pfam01555 1167634009000 DNA methylase; Region: N6_N4_Mtase; pfam01555 1167634009001 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1167634009002 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1167634009003 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1167634009004 putative active site [active] 1167634009005 putative NTP binding site [chemical binding]; other site 1167634009006 putative nucleic acid binding site [nucleotide binding]; other site 1167634009007 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1167634009008 Part of AAA domain; Region: AAA_19; pfam13245 1167634009009 Family description; Region: UvrD_C_2; pfam13538 1167634009010 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1167634009011 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1167634009012 Integrase; Region: Integrase_1; pfam12835 1167634009013 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634009014 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634009015 N-terminal plug; other site 1167634009016 ligand-binding site [chemical binding]; other site 1167634009017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634009018 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1167634009019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634009020 Walker A/P-loop; other site 1167634009021 Walker A/P-loop; other site 1167634009022 ATP binding site [chemical binding]; other site 1167634009023 ATP binding site [chemical binding]; other site 1167634009024 Q-loop/lid; other site 1167634009025 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634009026 ABC transporter signature motif; other site 1167634009027 Walker B; other site 1167634009028 D-loop; other site 1167634009029 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1167634009030 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634009031 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 1167634009032 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1167634009033 MarR family; Region: MarR; pfam01047 1167634009034 MarR family; Region: MarR_2; cl17246 1167634009035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634009036 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634009037 putative substrate translocation pore; other site 1167634009038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634009039 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1167634009040 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1167634009041 Benzoate membrane transport protein; Region: BenE; pfam03594 1167634009042 benzoate transporter; Region: benE; TIGR00843 1167634009043 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1167634009044 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1167634009045 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1167634009046 active site 1167634009047 (T/H)XGH motif; other site 1167634009048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634009049 S-adenosylmethionine binding site [chemical binding]; other site 1167634009050 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1167634009051 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1167634009052 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1167634009053 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1167634009054 putative active site [active] 1167634009055 putative metal binding residues [ion binding]; other site 1167634009056 signature motif; other site 1167634009057 putative triphosphate binding site [ion binding]; other site 1167634009058 CHAD domain; Region: CHAD; pfam05235 1167634009059 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1167634009060 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1167634009061 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1167634009062 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1167634009063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634009064 dimer interface [polypeptide binding]; other site 1167634009065 conserved gate region; other site 1167634009066 ABC-ATPase subunit interface; other site 1167634009067 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1167634009068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634009069 dimer interface [polypeptide binding]; other site 1167634009070 conserved gate region; other site 1167634009071 ABC-ATPase subunit interface; other site 1167634009072 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1167634009073 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1167634009074 Walker A/P-loop; other site 1167634009075 ATP binding site [chemical binding]; other site 1167634009076 Q-loop/lid; other site 1167634009077 ABC transporter signature motif; other site 1167634009078 Walker B; other site 1167634009079 D-loop; other site 1167634009080 H-loop/switch region; other site 1167634009081 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1167634009082 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634009083 substrate binding pocket [chemical binding]; other site 1167634009084 membrane-bound complex binding site; other site 1167634009085 hinge residues; other site 1167634009086 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1167634009087 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634009088 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634009089 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1167634009090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1167634009091 motif II; other site 1167634009092 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1167634009093 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1167634009094 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1167634009095 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1167634009096 dimerization interface [polypeptide binding]; other site 1167634009097 active site 1167634009098 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1167634009099 homopentamer interface [polypeptide binding]; other site 1167634009100 active site 1167634009101 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1167634009102 thiamine monophosphate kinase; Provisional; Region: PRK05731 1167634009103 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1167634009104 ATP binding site [chemical binding]; other site 1167634009105 dimerization interface [polypeptide binding]; other site 1167634009106 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1167634009107 tetramer interfaces [polypeptide binding]; other site 1167634009108 binuclear metal-binding site [ion binding]; other site 1167634009109 Competence-damaged protein; Region: CinA; pfam02464 1167634009110 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1167634009111 active site 1167634009112 dimer interface [polypeptide binding]; other site 1167634009113 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1167634009114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634009115 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1167634009116 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1167634009117 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1167634009118 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1167634009119 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634009120 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634009121 Walker A/P-loop; other site 1167634009122 ATP binding site [chemical binding]; other site 1167634009123 Q-loop/lid; other site 1167634009124 ABC transporter signature motif; other site 1167634009125 Walker B; other site 1167634009126 D-loop; other site 1167634009127 H-loop/switch region; other site 1167634009128 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634009129 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634009130 Walker A/P-loop; other site 1167634009131 ATP binding site [chemical binding]; other site 1167634009132 Q-loop/lid; other site 1167634009133 ABC transporter signature motif; other site 1167634009134 Walker B; other site 1167634009135 D-loop; other site 1167634009136 H-loop/switch region; other site 1167634009137 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634009138 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634009139 TM-ABC transporter signature motif; other site 1167634009140 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634009141 TM-ABC transporter signature motif; other site 1167634009142 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634009143 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 1167634009144 putative ligand binding site [chemical binding]; other site 1167634009145 Amidohydrolase; Region: Amidohydro_2; pfam04909 1167634009146 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 1167634009147 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1167634009148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009149 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1167634009150 putative dimerization interface [polypeptide binding]; other site 1167634009151 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1167634009152 homotrimer interaction site [polypeptide binding]; other site 1167634009153 putative active site [active] 1167634009154 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 1167634009155 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1167634009156 NAD binding site [chemical binding]; other site 1167634009157 catalytic residues [active] 1167634009158 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1167634009159 MarR family; Region: MarR_2; pfam12802 1167634009160 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1167634009161 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1167634009162 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1167634009163 ring oligomerisation interface [polypeptide binding]; other site 1167634009164 ATP/Mg binding site [chemical binding]; other site 1167634009165 stacking interactions; other site 1167634009166 hinge regions; other site 1167634009167 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1167634009168 oligomerisation interface [polypeptide binding]; other site 1167634009169 mobile loop; other site 1167634009170 roof hairpin; other site 1167634009171 putative transposase OrfB; Reviewed; Region: PHA02517 1167634009172 HTH-like domain; Region: HTH_21; pfam13276 1167634009173 Integrase core domain; Region: rve; pfam00665 1167634009174 Integrase core domain; Region: rve_3; pfam13683 1167634009175 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 1167634009176 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1167634009177 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1167634009178 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1167634009179 G1 box; other site 1167634009180 GTP/Mg2+ binding site [chemical binding]; other site 1167634009181 G2 box; other site 1167634009182 Switch I region; other site 1167634009183 G3 box; other site 1167634009184 Switch II region; other site 1167634009185 G4 box; other site 1167634009186 Outer membrane efflux protein; Region: OEP; pfam02321 1167634009187 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1167634009188 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634009189 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 1167634009190 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1167634009191 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634009192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634009193 Walker A/P-loop; other site 1167634009194 ATP binding site [chemical binding]; other site 1167634009195 Q-loop/lid; other site 1167634009196 ABC transporter signature motif; other site 1167634009197 Walker B; other site 1167634009198 D-loop; other site 1167634009199 H-loop/switch region; other site 1167634009200 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1167634009201 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1167634009202 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1167634009203 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1167634009204 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1167634009205 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1167634009206 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1167634009207 choline dehydrogenase; Validated; Region: PRK02106 1167634009208 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1167634009209 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1167634009210 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1167634009211 NAD(P) binding site [chemical binding]; other site 1167634009212 catalytic residues [active] 1167634009213 NMT1/THI5 like; Region: NMT1; pfam09084 1167634009214 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1167634009215 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634009216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634009217 dimer interface [polypeptide binding]; other site 1167634009218 conserved gate region; other site 1167634009219 putative PBP binding loops; other site 1167634009220 ABC-ATPase subunit interface; other site 1167634009221 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1167634009222 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634009223 Walker A/P-loop; other site 1167634009224 ATP binding site [chemical binding]; other site 1167634009225 Q-loop/lid; other site 1167634009226 ABC transporter signature motif; other site 1167634009227 Walker B; other site 1167634009228 D-loop; other site 1167634009229 H-loop/switch region; other site 1167634009230 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634009231 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1167634009232 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1167634009233 N-terminal domain interface [polypeptide binding]; other site 1167634009234 dimer interface [polypeptide binding]; other site 1167634009235 substrate binding pocket (H-site) [chemical binding]; other site 1167634009236 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1167634009237 homotrimer interaction site [polypeptide binding]; other site 1167634009238 putative active site [active] 1167634009239 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1167634009240 LVIVD repeat; Region: LVIVD; pfam08309 1167634009241 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1167634009242 Cupin domain; Region: Cupin_2; pfam07883 1167634009243 Cupin domain; Region: Cupin_2; cl17218 1167634009244 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1167634009245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1167634009246 DNA-binding site [nucleotide binding]; DNA binding site 1167634009247 FCD domain; Region: FCD; pfam07729 1167634009248 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1167634009249 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1167634009250 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1167634009251 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634009252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634009253 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1167634009254 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1167634009255 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1167634009256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634009257 S-adenosylmethionine binding site [chemical binding]; other site 1167634009258 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1167634009259 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 1167634009260 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1167634009261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634009262 S-adenosylmethionine binding site [chemical binding]; other site 1167634009263 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1167634009264 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1167634009265 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1167634009266 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1167634009267 Di-iron ligands [ion binding]; other site 1167634009268 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1167634009269 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1167634009270 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1167634009271 substrate binding pocket [chemical binding]; other site 1167634009272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 1167634009273 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1167634009274 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1167634009275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634009276 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634009277 DNA binding residues [nucleotide binding] 1167634009278 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634009279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634009280 active site 1167634009281 phosphorylation site [posttranslational modification] 1167634009282 intermolecular recognition site; other site 1167634009283 dimerization interface [polypeptide binding]; other site 1167634009284 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634009285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634009286 dimer interface [polypeptide binding]; other site 1167634009287 phosphorylation site [posttranslational modification] 1167634009288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634009289 ATP binding site [chemical binding]; other site 1167634009290 Mg2+ binding site [ion binding]; other site 1167634009291 G-X-G motif; other site 1167634009292 CheB methylesterase; Region: CheB_methylest; pfam01339 1167634009293 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1167634009294 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1167634009295 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1167634009296 CHASE3 domain; Region: CHASE3; pfam05227 1167634009297 GAF domain; Region: GAF_3; pfam13492 1167634009298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634009299 dimer interface [polypeptide binding]; other site 1167634009300 phosphorylation site [posttranslational modification] 1167634009301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634009302 ATP binding site [chemical binding]; other site 1167634009303 Mg2+ binding site [ion binding]; other site 1167634009304 G-X-G motif; other site 1167634009305 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634009306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634009307 active site 1167634009308 phosphorylation site [posttranslational modification] 1167634009309 intermolecular recognition site; other site 1167634009310 dimerization interface [polypeptide binding]; other site 1167634009311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634009312 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634009313 active site 1167634009314 phosphorylation site [posttranslational modification] 1167634009315 intermolecular recognition site; other site 1167634009316 dimerization interface [polypeptide binding]; other site 1167634009317 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634009318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634009319 active site 1167634009320 phosphorylation site [posttranslational modification] 1167634009321 intermolecular recognition site; other site 1167634009322 dimerization interface [polypeptide binding]; other site 1167634009323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634009324 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634009325 active site 1167634009326 phosphorylation site [posttranslational modification] 1167634009327 intermolecular recognition site; other site 1167634009328 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634009329 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634009330 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634009331 N-terminal plug; other site 1167634009332 ligand-binding site [chemical binding]; other site 1167634009333 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634009334 FecR protein; Region: FecR; pfam04773 1167634009335 RNA polymerase sigma factor; Provisional; Region: PRK12528 1167634009336 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1167634009337 DNA binding residues [nucleotide binding] 1167634009338 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1167634009339 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1167634009340 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1167634009341 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1167634009342 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1167634009343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634009344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009345 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634009346 putative effector binding pocket; other site 1167634009347 dimerization interface [polypeptide binding]; other site 1167634009348 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1167634009349 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1167634009350 Putative cyclase; Region: Cyclase; pfam04199 1167634009351 PAS domain S-box; Region: sensory_box; TIGR00229 1167634009352 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634009353 putative active site [active] 1167634009354 heme pocket [chemical binding]; other site 1167634009355 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634009356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634009357 DNA binding residues [nucleotide binding] 1167634009358 dimerization interface [polypeptide binding]; other site 1167634009359 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1167634009360 metal binding site [ion binding]; metal-binding site 1167634009361 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 1167634009362 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1167634009363 dimer interface [polypeptide binding]; other site 1167634009364 acyl-activating enzyme (AAE) consensus motif; other site 1167634009365 putative active site [active] 1167634009366 AMP binding site [chemical binding]; other site 1167634009367 putative CoA binding site [chemical binding]; other site 1167634009368 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1167634009369 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1167634009370 trimer interface [polypeptide binding]; other site 1167634009371 eyelet of channel; other site 1167634009372 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1167634009373 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 1167634009374 putative ligand binding site [chemical binding]; other site 1167634009375 putative NAD binding site [chemical binding]; other site 1167634009376 catalytic site [active] 1167634009377 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1167634009378 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1167634009379 metal binding site [ion binding]; metal-binding site 1167634009380 substrate binding pocket [chemical binding]; other site 1167634009381 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634009382 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1167634009383 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1167634009384 active site 1167634009385 inhibitor site; inhibition site 1167634009386 dimer interface [polypeptide binding]; other site 1167634009387 catalytic residue [active] 1167634009388 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634009389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009390 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1167634009391 dimerization interface [polypeptide binding]; other site 1167634009392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634009393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634009394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634009395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634009397 dimerization interface [polypeptide binding]; other site 1167634009398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634009399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009400 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634009401 dimerization interface [polypeptide binding]; other site 1167634009402 aspartate aminotransferase; Provisional; Region: PRK05764 1167634009403 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634009404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634009405 homodimer interface [polypeptide binding]; other site 1167634009406 catalytic residue [active] 1167634009407 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1167634009408 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1167634009409 PYR/PP interface [polypeptide binding]; other site 1167634009410 dimer interface [polypeptide binding]; other site 1167634009411 TPP binding site [chemical binding]; other site 1167634009412 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1167634009413 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1167634009414 TPP-binding site [chemical binding]; other site 1167634009415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634009416 acetylornithine deacetylase; Provisional; Region: PRK07522 1167634009417 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1167634009418 metal binding site [ion binding]; metal-binding site 1167634009419 putative dimer interface [polypeptide binding]; other site 1167634009420 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634009421 EamA-like transporter family; Region: EamA; pfam00892 1167634009422 EamA-like transporter family; Region: EamA; pfam00892 1167634009423 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634009424 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634009425 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634009426 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634009427 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634009428 active site 1167634009429 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1167634009430 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1167634009431 dimer interface [polypeptide binding]; other site 1167634009432 catalytic residues [active] 1167634009433 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634009434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634009435 dimer interface [polypeptide binding]; other site 1167634009436 phosphorylation site [posttranslational modification] 1167634009437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634009438 ATP binding site [chemical binding]; other site 1167634009439 Mg2+ binding site [ion binding]; other site 1167634009440 G-X-G motif; other site 1167634009441 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634009442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634009443 active site 1167634009444 phosphorylation site [posttranslational modification] 1167634009445 intermolecular recognition site; other site 1167634009446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634009447 dimerization interface [polypeptide binding]; other site 1167634009448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634009449 dimer interface [polypeptide binding]; other site 1167634009450 phosphorylation site [posttranslational modification] 1167634009451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634009452 ATP binding site [chemical binding]; other site 1167634009453 Mg2+ binding site [ion binding]; other site 1167634009454 G-X-G motif; other site 1167634009455 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634009456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634009457 active site 1167634009458 phosphorylation site [posttranslational modification] 1167634009459 intermolecular recognition site; other site 1167634009460 dimerization interface [polypeptide binding]; other site 1167634009461 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1167634009462 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634009463 DNA binding residues [nucleotide binding] 1167634009464 fec operon regulator FecR; Reviewed; Region: PRK09774 1167634009465 FecR protein; Region: FecR; pfam04773 1167634009466 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634009467 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634009468 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634009469 N-terminal plug; other site 1167634009470 ligand-binding site [chemical binding]; other site 1167634009471 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1167634009472 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1167634009473 ATP-dependent DNA ligase; Validated; Region: PRK09247 1167634009474 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 1167634009475 active site 1167634009476 DNA binding site [nucleotide binding] 1167634009477 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1167634009478 DNA binding site [nucleotide binding] 1167634009479 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 1167634009480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1167634009481 ATP binding site [chemical binding]; other site 1167634009482 putative Mg++ binding site [ion binding]; other site 1167634009483 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634009484 nucleotide binding region [chemical binding]; other site 1167634009485 ATP-binding site [chemical binding]; other site 1167634009486 DEAD/H associated; Region: DEAD_assoc; pfam08494 1167634009487 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1167634009488 active site 1167634009489 metal binding site [ion binding]; metal-binding site 1167634009490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634009491 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1167634009492 Walker A/P-loop; other site 1167634009493 ATP binding site [chemical binding]; other site 1167634009494 Q-loop/lid; other site 1167634009495 ABC transporter signature motif; other site 1167634009496 Walker B; other site 1167634009497 D-loop; other site 1167634009498 H-loop/switch region; other site 1167634009499 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1167634009500 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634009501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634009502 Walker A/P-loop; other site 1167634009503 ATP binding site [chemical binding]; other site 1167634009504 Q-loop/lid; other site 1167634009505 ABC transporter signature motif; other site 1167634009506 Walker B; other site 1167634009507 D-loop; other site 1167634009508 H-loop/switch region; other site 1167634009509 muropeptide transporter; Validated; Region: ampG; cl17669 1167634009510 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1167634009511 putative metal binding site [ion binding]; other site 1167634009512 putative homodimer interface [polypeptide binding]; other site 1167634009513 putative homotetramer interface [polypeptide binding]; other site 1167634009514 putative homodimer-homodimer interface [polypeptide binding]; other site 1167634009515 putative allosteric switch controlling residues; other site 1167634009516 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1167634009517 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1167634009518 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1167634009519 dimer interface [polypeptide binding]; other site 1167634009520 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1167634009521 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1167634009522 PYR/PP interface [polypeptide binding]; other site 1167634009523 dimer interface [polypeptide binding]; other site 1167634009524 tetramer interface [polypeptide binding]; other site 1167634009525 TPP binding site [chemical binding]; other site 1167634009526 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1167634009527 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1167634009528 TPP-binding site [chemical binding]; other site 1167634009529 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1167634009530 PRC-barrel domain; Region: PRC; pfam05239 1167634009531 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1167634009532 aldolase II superfamily protein; Provisional; Region: PRK07044 1167634009533 intersubunit interface [polypeptide binding]; other site 1167634009534 active site 1167634009535 Zn2+ binding site [ion binding]; other site 1167634009536 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634009537 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009538 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1167634009539 putative dimerization interface [polypeptide binding]; other site 1167634009540 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1167634009541 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1167634009542 dimerization interface [polypeptide binding]; other site 1167634009543 NAD binding site [chemical binding]; other site 1167634009544 ligand binding site [chemical binding]; other site 1167634009545 catalytic site [active] 1167634009546 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1167634009547 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1167634009548 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1167634009549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634009550 Coenzyme A binding pocket [chemical binding]; other site 1167634009551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1167634009552 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634009553 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1167634009554 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1167634009555 molybdopterin cofactor binding site [chemical binding]; other site 1167634009556 substrate binding site [chemical binding]; other site 1167634009557 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1167634009558 molybdopterin cofactor binding site; other site 1167634009559 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1167634009560 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1167634009561 dimer interface [polypeptide binding]; other site 1167634009562 active site 1167634009563 catalytic residue [active] 1167634009564 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634009565 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1167634009566 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1167634009567 conserved cys residue [active] 1167634009568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634009569 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1167634009570 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1167634009571 conserved cys residue [active] 1167634009572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634009573 putative substrate translocation pore; other site 1167634009574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634009575 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634009576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634009577 drug efflux system protein MdtG; Provisional; Region: PRK09874 1167634009578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634009579 putative substrate translocation pore; other site 1167634009580 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1167634009581 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1167634009582 oligomer interface [polypeptide binding]; other site 1167634009583 active site residues [active] 1167634009584 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1167634009585 putative hydrophobic ligand binding site [chemical binding]; other site 1167634009586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634009587 dimerization interface [polypeptide binding]; other site 1167634009588 putative DNA binding site [nucleotide binding]; other site 1167634009589 putative Zn2+ binding site [ion binding]; other site 1167634009590 GAF domain; Region: GAF; cl17456 1167634009591 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634009592 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634009593 metal binding site [ion binding]; metal-binding site 1167634009594 active site 1167634009595 I-site; other site 1167634009596 Cache domain; Region: Cache_1; pfam02743 1167634009597 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634009598 dimerization interface [polypeptide binding]; other site 1167634009599 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634009600 dimer interface [polypeptide binding]; other site 1167634009601 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1167634009602 putative CheW interface [polypeptide binding]; other site 1167634009603 hypothetical protein; Provisional; Region: PRK07236 1167634009604 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634009605 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634009606 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634009607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634009608 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1167634009609 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 1167634009610 putative active site pocket [active] 1167634009611 metal binding site [ion binding]; metal-binding site 1167634009612 transcriptional activator TtdR; Provisional; Region: PRK09801 1167634009613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009614 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1167634009615 putative effector binding pocket; other site 1167634009616 putative dimerization interface [polypeptide binding]; other site 1167634009617 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 1167634009618 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1167634009619 putative rRNA binding site [nucleotide binding]; other site 1167634009620 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634009621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634009623 dimerization interface [polypeptide binding]; other site 1167634009624 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1167634009625 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1167634009626 active site 1167634009627 catalytic tetrad [active] 1167634009628 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1167634009629 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1167634009630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634009631 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1167634009632 NAD(P) binding site [chemical binding]; other site 1167634009633 active site 1167634009634 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1167634009635 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1167634009636 active site 1167634009637 catalytic tetrad [active] 1167634009638 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1167634009639 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1167634009640 [4Fe-4S] binding site [ion binding]; other site 1167634009641 molybdopterin cofactor binding site; other site 1167634009642 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1167634009643 molybdopterin cofactor binding site; other site 1167634009644 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1167634009645 Flavodoxin; Region: Flavodoxin_1; pfam00258 1167634009646 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1167634009647 FAD binding pocket [chemical binding]; other site 1167634009648 FAD binding motif [chemical binding]; other site 1167634009649 catalytic residues [active] 1167634009650 NAD binding pocket [chemical binding]; other site 1167634009651 phosphate binding motif [ion binding]; other site 1167634009652 beta-alpha-beta structure motif; other site 1167634009653 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1167634009654 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634009655 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1167634009656 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1167634009657 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1167634009658 Nitrate and nitrite sensing; Region: NIT; pfam08376 1167634009659 ANTAR domain; Region: ANTAR; pfam03861 1167634009660 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1167634009661 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1167634009662 active site 1167634009663 metal binding site [ion binding]; metal-binding site 1167634009664 MarR family; Region: MarR_2; pfam12802 1167634009665 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1167634009666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634009667 Coenzyme A binding pocket [chemical binding]; other site 1167634009668 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1167634009669 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1167634009670 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1167634009671 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1167634009672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1167634009673 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1167634009674 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1167634009675 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1167634009676 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1167634009677 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1167634009678 transcriptional regulator RcsB; Provisional; Region: PRK10840 1167634009679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634009680 active site 1167634009681 phosphorylation site [posttranslational modification] 1167634009682 intermolecular recognition site; other site 1167634009683 dimerization interface [polypeptide binding]; other site 1167634009684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634009685 DNA binding residues [nucleotide binding] 1167634009686 dimerization interface [polypeptide binding]; other site 1167634009687 HTH domain; Region: HTH_11; pfam08279 1167634009688 Predicted transcriptional regulator [Transcription]; Region: COG2378 1167634009689 WYL domain; Region: WYL; pfam13280 1167634009690 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1167634009691 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634009692 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1167634009693 N-terminal domain interface [polypeptide binding]; other site 1167634009694 dimer interface [polypeptide binding]; other site 1167634009695 substrate binding pocket (H-site) [chemical binding]; other site 1167634009696 Putative ParB-like nuclease; Region: ParBc_2; cl17538 1167634009697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634009698 putative DNA binding site [nucleotide binding]; other site 1167634009699 dimerization interface [polypeptide binding]; other site 1167634009700 putative Zn2+ binding site [ion binding]; other site 1167634009701 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1167634009702 active site residue [active] 1167634009703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634009704 putative substrate translocation pore; other site 1167634009705 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1167634009706 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634009707 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1167634009708 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1167634009709 trimer interface [polypeptide binding]; other site 1167634009710 eyelet of channel; other site 1167634009711 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1167634009712 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1167634009713 trimer interface [polypeptide binding]; other site 1167634009714 eyelet of channel; other site 1167634009715 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1167634009716 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1167634009717 eyelet of channel; other site 1167634009718 trimer interface [polypeptide binding]; other site 1167634009719 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1167634009720 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1167634009721 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1167634009722 Subunit I/III interface [polypeptide binding]; other site 1167634009723 Subunit III/IV interface [polypeptide binding]; other site 1167634009724 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1167634009725 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1167634009726 D-pathway; other site 1167634009727 Putative ubiquinol binding site [chemical binding]; other site 1167634009728 Low-spin heme (heme b) binding site [chemical binding]; other site 1167634009729 Putative water exit pathway; other site 1167634009730 Binuclear center (heme o3/CuB) [ion binding]; other site 1167634009731 K-pathway; other site 1167634009732 Putative proton exit pathway; other site 1167634009733 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1167634009734 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1167634009735 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1167634009736 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634009737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634009738 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1167634009739 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634009740 substrate binding pocket [chemical binding]; other site 1167634009741 membrane-bound complex binding site; other site 1167634009742 hinge residues; other site 1167634009743 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1167634009744 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1167634009745 inhibitor-cofactor binding pocket; inhibition site 1167634009746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634009747 catalytic residue [active] 1167634009748 cell density-dependent motility repressor; Provisional; Region: PRK10082 1167634009749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009750 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634009751 dimerization interface [polypeptide binding]; other site 1167634009752 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1167634009753 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1167634009754 active site 1167634009755 Zn binding site [ion binding]; other site 1167634009756 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1167634009757 putative active site [active] 1167634009758 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1167634009759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634009761 dimerization interface [polypeptide binding]; other site 1167634009762 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1167634009763 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634009764 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1167634009765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634009766 S-adenosylmethionine binding site [chemical binding]; other site 1167634009767 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634009768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634009769 cyanate transporter; Region: CynX; TIGR00896 1167634009770 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1167634009771 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1167634009772 active site 1167634009773 Zn binding site [ion binding]; other site 1167634009774 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1167634009775 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1167634009776 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1167634009777 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1167634009778 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1167634009779 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634009780 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1167634009781 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634009782 DNA binding residues [nucleotide binding] 1167634009783 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634009784 FecR protein; Region: FecR; pfam04773 1167634009785 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634009786 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634009787 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634009788 N-terminal plug; other site 1167634009789 ligand-binding site [chemical binding]; other site 1167634009790 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1167634009791 classical (c) SDRs; Region: SDR_c; cd05233 1167634009792 NAD(P) binding site [chemical binding]; other site 1167634009793 active site 1167634009794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634009795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009796 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1167634009797 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634009798 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634009799 DNA binding residues [nucleotide binding] 1167634009800 fec operon regulator FecR; Reviewed; Region: PRK09774 1167634009801 FecR protein; Region: FecR; pfam04773 1167634009802 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634009803 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634009804 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634009805 N-terminal plug; other site 1167634009806 ligand-binding site [chemical binding]; other site 1167634009807 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634009808 DNA-binding site [nucleotide binding]; DNA binding site 1167634009809 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634009810 FCD domain; Region: FCD; pfam07729 1167634009811 aconitate hydratase; Provisional; Region: acnA; PRK12881 1167634009812 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1167634009813 substrate binding site [chemical binding]; other site 1167634009814 ligand binding site [chemical binding]; other site 1167634009815 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1167634009816 substrate binding site [chemical binding]; other site 1167634009817 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606 1167634009818 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1167634009819 endonuclease III; Region: ENDO3c; smart00478 1167634009820 minor groove reading motif; other site 1167634009821 helix-hairpin-helix signature motif; other site 1167634009822 substrate binding pocket [chemical binding]; other site 1167634009823 active site 1167634009824 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1167634009825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634009826 motif II; other site 1167634009827 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1167634009828 short chain dehydrogenase; Provisional; Region: PRK06125 1167634009829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634009830 NAD(P) binding site [chemical binding]; other site 1167634009831 active site 1167634009832 MgtC family; Region: MgtC; pfam02308 1167634009833 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1167634009834 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1167634009835 Helix-turn-helix domain; Region: HTH_18; pfam12833 1167634009836 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634009837 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1167634009838 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1167634009839 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1167634009840 Cupin; Region: Cupin_6; pfam12852 1167634009841 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634009842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634009843 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1167634009844 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1167634009845 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1167634009846 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1167634009847 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1167634009848 PLD-like domain; Region: PLDc_2; pfam13091 1167634009849 putative active site [active] 1167634009850 catalytic site [active] 1167634009851 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1167634009852 PLD-like domain; Region: PLDc_2; pfam13091 1167634009853 putative active site [active] 1167634009854 catalytic site [active] 1167634009855 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1167634009856 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634009857 non-specific DNA binding site [nucleotide binding]; other site 1167634009858 salt bridge; other site 1167634009859 sequence-specific DNA binding site [nucleotide binding]; other site 1167634009860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634009861 Coenzyme A binding pocket [chemical binding]; other site 1167634009862 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1167634009863 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634009864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009865 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634009866 dimerization interface [polypeptide binding]; other site 1167634009867 short chain dehydrogenase; Provisional; Region: PRK06180 1167634009868 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1167634009869 NADP binding site [chemical binding]; other site 1167634009870 active site 1167634009871 steroid binding site; other site 1167634009872 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1167634009873 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1167634009874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634009875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009876 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1167634009877 putative dimerization interface [polypeptide binding]; other site 1167634009878 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 1167634009879 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1167634009880 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1167634009881 MarR family; Region: MarR_2; pfam12802 1167634009882 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1167634009883 B3/4 domain; Region: B3_4; pfam03483 1167634009884 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634009885 EamA-like transporter family; Region: EamA; pfam00892 1167634009886 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1167634009887 Helix-turn-helix domain; Region: HTH_18; pfam12833 1167634009888 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634009889 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1167634009890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009891 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634009892 dimerization interface [polypeptide binding]; other site 1167634009893 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1167634009894 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1167634009895 SlyX; Region: SlyX; cl01090 1167634009896 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1167634009897 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634009898 N-terminal plug; other site 1167634009899 ligand-binding site [chemical binding]; other site 1167634009900 NifQ; Region: NifQ; pfam04891 1167634009901 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1167634009902 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1167634009903 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1167634009904 Subunit I/III interface [polypeptide binding]; other site 1167634009905 Subunit III/IV interface [polypeptide binding]; other site 1167634009906 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1167634009907 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1167634009908 D-pathway; other site 1167634009909 Putative ubiquinol binding site [chemical binding]; other site 1167634009910 Low-spin heme (heme b) binding site [chemical binding]; other site 1167634009911 Putative water exit pathway; other site 1167634009912 Binuclear center (heme o3/CuB) [ion binding]; other site 1167634009913 K-pathway; other site 1167634009914 Putative proton exit pathway; other site 1167634009915 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1167634009916 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1167634009917 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1167634009918 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1167634009919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634009920 active site 1167634009921 phosphorylation site [posttranslational modification] 1167634009922 intermolecular recognition site; other site 1167634009923 dimerization interface [polypeptide binding]; other site 1167634009924 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1167634009925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634009926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634009927 ATP binding site [chemical binding]; other site 1167634009928 G-X-G motif; other site 1167634009929 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1167634009930 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1167634009931 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1167634009932 Cu(I) binding site [ion binding]; other site 1167634009933 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1167634009934 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 1167634009935 acyl-CoA binding pocket [chemical binding]; other site 1167634009936 CoA binding site [chemical binding]; other site 1167634009937 MASE1; Region: MASE1; cl17823 1167634009938 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1167634009939 Peptidase family M23; Region: Peptidase_M23; pfam01551 1167634009940 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634009941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634009942 Walker A/P-loop; other site 1167634009943 ATP binding site [chemical binding]; other site 1167634009944 Q-loop/lid; other site 1167634009945 ABC transporter signature motif; other site 1167634009946 Walker B; other site 1167634009947 D-loop; other site 1167634009948 H-loop/switch region; other site 1167634009949 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1167634009950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634009951 dimer interface [polypeptide binding]; other site 1167634009952 conserved gate region; other site 1167634009953 putative PBP binding loops; other site 1167634009954 ABC-ATPase subunit interface; other site 1167634009955 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634009956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634009957 substrate binding pocket [chemical binding]; other site 1167634009958 membrane-bound complex binding site; other site 1167634009959 hinge residues; other site 1167634009960 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1167634009961 putative active site pocket [active] 1167634009962 cleavage site 1167634009963 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1167634009964 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634009965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634009966 putative DNA binding site [nucleotide binding]; other site 1167634009967 putative Zn2+ binding site [ion binding]; other site 1167634009968 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634009969 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 1167634009970 kynureninase; Region: kynureninase; TIGR01814 1167634009971 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634009972 catalytic residue [active] 1167634009973 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1167634009974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634009975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009976 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634009977 putative effector binding pocket; other site 1167634009978 dimerization interface [polypeptide binding]; other site 1167634009979 threonine synthase; Validated; Region: PRK08197 1167634009980 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1167634009981 homodimer interface [polypeptide binding]; other site 1167634009982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634009983 catalytic residue [active] 1167634009984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634009985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634009986 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1167634009987 putative dimerization interface [polypeptide binding]; other site 1167634009988 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1167634009989 transmembrane helices; other site 1167634009990 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1167634009991 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634009992 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 1167634009993 putative dimer interface [polypeptide binding]; other site 1167634009994 Predicted transcriptional regulator [Transcription]; Region: COG2378 1167634009995 HTH domain; Region: HTH_11; pfam08279 1167634009996 WYL domain; Region: WYL; pfam13280 1167634009997 Predicted integral membrane protein [Function unknown]; Region: COG5615 1167634009998 RNA polymerase sigma factor; Provisional; Region: PRK12528 1167634009999 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634010000 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634010001 DNA binding residues [nucleotide binding] 1167634010002 fec operon regulator FecR; Reviewed; Region: PRK09774 1167634010003 FecR protein; Region: FecR; pfam04773 1167634010004 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1167634010005 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634010006 N-terminal plug; other site 1167634010007 ligand-binding site [chemical binding]; other site 1167634010008 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1167634010009 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1167634010010 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1167634010011 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1167634010012 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1167634010013 intersubunit interface [polypeptide binding]; other site 1167634010014 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1167634010015 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1167634010016 ABC-ATPase subunit interface; other site 1167634010017 dimer interface [polypeptide binding]; other site 1167634010018 putative PBP binding regions; other site 1167634010019 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1167634010020 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1167634010021 Walker A/P-loop; other site 1167634010022 ATP binding site [chemical binding]; other site 1167634010023 Q-loop/lid; other site 1167634010024 ABC transporter signature motif; other site 1167634010025 Walker B; other site 1167634010026 D-loop; other site 1167634010027 H-loop/switch region; other site 1167634010028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1167634010029 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1167634010030 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1167634010031 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1167634010032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634010033 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1167634010034 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1167634010035 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1167634010036 minor groove reading motif; other site 1167634010037 helix-hairpin-helix signature motif; other site 1167634010038 substrate binding pocket [chemical binding]; other site 1167634010039 active site 1167634010040 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1167634010041 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1167634010042 DNA binding site [nucleotide binding] 1167634010043 active site 1167634010044 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1167634010045 active site 1167634010046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1167634010047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634010048 ATP binding site [chemical binding]; other site 1167634010049 Mg2+ binding site [ion binding]; other site 1167634010050 G-X-G motif; other site 1167634010051 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634010052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634010053 active site 1167634010054 phosphorylation site [posttranslational modification] 1167634010055 intermolecular recognition site; other site 1167634010056 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634010057 DNA binding residues [nucleotide binding] 1167634010058 dimerization interface [polypeptide binding]; other site 1167634010059 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1167634010060 ArsC family; Region: ArsC; pfam03960 1167634010061 catalytic residues [active] 1167634010062 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1167634010063 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1167634010064 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634010065 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634010066 N-terminal plug; other site 1167634010067 ligand-binding site [chemical binding]; other site 1167634010068 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1167634010069 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634010070 Walker A/P-loop; other site 1167634010071 ATP binding site [chemical binding]; other site 1167634010072 Q-loop/lid; other site 1167634010073 ABC transporter signature motif; other site 1167634010074 Walker B; other site 1167634010075 D-loop; other site 1167634010076 H-loop/switch region; other site 1167634010077 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1167634010078 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634010079 Walker A/P-loop; other site 1167634010080 ATP binding site [chemical binding]; other site 1167634010081 Q-loop/lid; other site 1167634010082 ABC transporter signature motif; other site 1167634010083 Walker B; other site 1167634010084 D-loop; other site 1167634010085 H-loop/switch region; other site 1167634010086 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634010087 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634010088 TM-ABC transporter signature motif; other site 1167634010089 HEAT repeats; Region: HEAT_2; pfam13646 1167634010090 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634010091 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634010092 TM-ABC transporter signature motif; other site 1167634010093 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634010094 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1167634010095 putative ligand binding site [chemical binding]; other site 1167634010096 allophanate hydrolase; Provisional; Region: PRK08186 1167634010097 Amidase; Region: Amidase; cl11426 1167634010098 urea carboxylase; Region: urea_carbox; TIGR02712 1167634010099 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1167634010100 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1167634010101 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1167634010102 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1167634010103 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1167634010104 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1167634010105 carboxyltransferase (CT) interaction site; other site 1167634010106 biotinylation site [posttranslational modification]; other site 1167634010107 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1167634010108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634010109 DNA-binding site [nucleotide binding]; DNA binding site 1167634010110 FCD domain; Region: FCD; pfam07729 1167634010111 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1167634010112 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1167634010113 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634010114 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634010115 DNA binding residues [nucleotide binding] 1167634010116 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1167634010117 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1167634010118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634010119 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1167634010120 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1167634010121 putative dimerization interface [polypeptide binding]; other site 1167634010122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1167634010123 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634010124 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1167634010125 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1167634010126 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1167634010127 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1167634010128 putative NAD(P) binding site [chemical binding]; other site 1167634010129 putative active site [active] 1167634010130 azurin; Region: azurin; TIGR02695 1167634010131 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1167634010132 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1167634010133 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1167634010134 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1167634010135 FAD binding pocket [chemical binding]; other site 1167634010136 FAD binding motif [chemical binding]; other site 1167634010137 phosphate binding motif [ion binding]; other site 1167634010138 beta-alpha-beta structure motif; other site 1167634010139 NAD binding pocket [chemical binding]; other site 1167634010140 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1167634010141 Predicted membrane protein [Function unknown]; Region: COG3212 1167634010142 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1167634010143 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634010144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634010145 active site 1167634010146 phosphorylation site [posttranslational modification] 1167634010147 intermolecular recognition site; other site 1167634010148 dimerization interface [polypeptide binding]; other site 1167634010149 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634010150 DNA binding site [nucleotide binding] 1167634010151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634010152 ATP binding site [chemical binding]; other site 1167634010153 Mg2+ binding site [ion binding]; other site 1167634010154 G-X-G motif; other site 1167634010155 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1167634010156 Ligand Binding Site [chemical binding]; other site 1167634010157 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1167634010158 Ligand Binding Site [chemical binding]; other site 1167634010159 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1167634010160 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1167634010161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634010162 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1167634010163 putative dimerization interface [polypeptide binding]; other site 1167634010164 putative substrate binding pocket [chemical binding]; other site 1167634010165 Chromate transporter; Region: Chromate_transp; pfam02417 1167634010166 Chromate transporter; Region: Chromate_transp; pfam02417 1167634010167 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1167634010168 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1167634010169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634010170 S-adenosylmethionine binding site [chemical binding]; other site 1167634010171 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634010172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634010173 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1167634010174 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1167634010175 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1167634010176 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1167634010177 catalytic loop [active] 1167634010178 iron binding site [ion binding]; other site 1167634010179 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1167634010180 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1167634010181 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1167634010182 [4Fe-4S] binding site [ion binding]; other site 1167634010183 molybdopterin cofactor binding site; other site 1167634010184 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1167634010185 molybdopterin cofactor binding site; other site 1167634010186 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 1167634010187 putative dimer interface [polypeptide binding]; other site 1167634010188 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1167634010189 SLBB domain; Region: SLBB; pfam10531 1167634010190 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1167634010191 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 1167634010192 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 1167634010193 putative dimer interface [polypeptide binding]; other site 1167634010194 [2Fe-2S] cluster binding site [ion binding]; other site 1167634010195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634010196 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1167634010197 PBP superfamily domain; Region: PBP_like; pfam12727 1167634010198 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1167634010199 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1167634010200 FeS/SAM binding site; other site 1167634010201 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1167634010202 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1167634010203 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1167634010204 GTP binding site; other site 1167634010205 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1167634010206 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1167634010207 dimer interface [polypeptide binding]; other site 1167634010208 putative functional site; other site 1167634010209 putative MPT binding site; other site 1167634010210 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1167634010211 MPT binding site; other site 1167634010212 trimer interface [polypeptide binding]; other site 1167634010213 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1167634010214 MoaE homodimer interface [polypeptide binding]; other site 1167634010215 MoaD interaction [polypeptide binding]; other site 1167634010216 active site residues [active] 1167634010217 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1167634010218 MoaE interaction surface [polypeptide binding]; other site 1167634010219 MoeB interaction surface [polypeptide binding]; other site 1167634010220 thiocarboxylated glycine; other site 1167634010221 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1167634010222 trimer interface [polypeptide binding]; other site 1167634010223 dimer interface [polypeptide binding]; other site 1167634010224 putative active site [active] 1167634010225 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1167634010226 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1167634010227 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1167634010228 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1167634010229 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1167634010230 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1167634010231 catalytic triad [active] 1167634010232 dimer interface [polypeptide binding]; other site 1167634010233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634010234 putative MFS family transporter protein; Provisional; Region: PRK03633 1167634010235 putative substrate translocation pore; other site 1167634010236 biotin synthase; Region: bioB; TIGR00433 1167634010237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1167634010238 FeS/SAM binding site; other site 1167634010239 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1167634010240 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1167634010241 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1167634010242 putative active site [active] 1167634010243 heme pocket [chemical binding]; other site 1167634010244 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634010245 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634010246 DNA binding residues [nucleotide binding] 1167634010247 dimerization interface [polypeptide binding]; other site 1167634010248 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1167634010249 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1167634010250 active site 1167634010251 catalytic tetrad [active] 1167634010252 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1167634010253 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1167634010254 putative active site [active] 1167634010255 catalytic triad [active] 1167634010256 putative dimer interface [polypeptide binding]; other site 1167634010257 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1167634010258 Transporter associated domain; Region: CorC_HlyC; smart01091 1167634010259 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 1167634010260 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1167634010261 PhoH-like protein; Region: PhoH; pfam02562 1167634010262 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1167634010263 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1167634010264 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1167634010265 FeS/SAM binding site; other site 1167634010266 TRAM domain; Region: TRAM; pfam01938 1167634010267 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 1167634010268 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1167634010269 active site 1167634010270 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1167634010271 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1167634010272 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1167634010273 Helix-turn-helix domain; Region: HTH_37; pfam13744 1167634010274 non-specific DNA binding site [nucleotide binding]; other site 1167634010275 salt bridge; other site 1167634010276 sequence-specific DNA binding site [nucleotide binding]; other site 1167634010277 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1167634010278 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1167634010279 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1167634010280 Protein export membrane protein; Region: SecD_SecF; pfam02355 1167634010281 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1167634010282 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1167634010283 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1167634010284 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1167634010285 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1167634010286 RelB antitoxin; Region: RelB; cl01171 1167634010287 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1167634010288 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1167634010289 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1167634010290 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1167634010291 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1167634010292 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1167634010293 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634010294 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634010295 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1167634010296 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1167634010297 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1167634010298 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1167634010299 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1167634010300 putative ligand binding site [chemical binding]; other site 1167634010301 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1167634010302 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1167634010303 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1167634010304 active site 1167634010305 siroheme synthase; Provisional; Region: cysG; PRK10637 1167634010306 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1167634010307 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1167634010308 active site 1167634010309 SAM binding site [chemical binding]; other site 1167634010310 homodimer interface [polypeptide binding]; other site 1167634010311 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1167634010312 NMT1-like family; Region: NMT1_2; pfam13379 1167634010313 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634010314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634010315 dimer interface [polypeptide binding]; other site 1167634010316 conserved gate region; other site 1167634010317 putative PBP binding loops; other site 1167634010318 ABC-ATPase subunit interface; other site 1167634010319 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1167634010320 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634010321 Walker A/P-loop; other site 1167634010322 ATP binding site [chemical binding]; other site 1167634010323 Q-loop/lid; other site 1167634010324 ABC transporter signature motif; other site 1167634010325 Walker B; other site 1167634010326 D-loop; other site 1167634010327 H-loop/switch region; other site 1167634010328 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1167634010329 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1167634010330 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1167634010331 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1167634010332 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1167634010333 catalytic residue [active] 1167634010334 Fimbrial protein; Region: Fimbrial; pfam00419 1167634010335 Fimbrial protein; Region: Fimbrial; cl01416 1167634010336 aminotransferase; Validated; Region: PRK07337 1167634010337 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634010338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634010339 homodimer interface [polypeptide binding]; other site 1167634010340 catalytic residue [active] 1167634010341 malic enzyme; Reviewed; Region: PRK12862 1167634010342 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1167634010343 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1167634010344 putative NAD(P) binding site [chemical binding]; other site 1167634010345 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1167634010346 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1167634010347 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1167634010348 active site 1167634010349 nucleophile elbow; other site 1167634010350 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1167634010351 putative RNAase interaction site [polypeptide binding]; other site 1167634010352 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1167634010353 transketolase; Reviewed; Region: PRK12753 1167634010354 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1167634010355 TPP-binding site [chemical binding]; other site 1167634010356 dimer interface [polypeptide binding]; other site 1167634010357 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1167634010358 PYR/PP interface [polypeptide binding]; other site 1167634010359 dimer interface [polypeptide binding]; other site 1167634010360 TPP binding site [chemical binding]; other site 1167634010361 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1167634010362 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1167634010363 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1167634010364 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1167634010365 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1167634010366 Phosphoglycerate kinase; Region: PGK; pfam00162 1167634010367 substrate binding site [chemical binding]; other site 1167634010368 hinge regions; other site 1167634010369 ADP binding site [chemical binding]; other site 1167634010370 catalytic site [active] 1167634010371 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634010372 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1167634010373 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1167634010374 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1167634010375 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1167634010376 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 1167634010377 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1167634010378 NAD binding site [chemical binding]; other site 1167634010379 homotetramer interface [polypeptide binding]; other site 1167634010380 homodimer interface [polypeptide binding]; other site 1167634010381 substrate binding site [chemical binding]; other site 1167634010382 active site 1167634010383 propionate/acetate kinase; Provisional; Region: PRK12379 1167634010384 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1167634010385 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 1167634010386 phosphate acetyltransferase; Provisional; Region: PRK11890 1167634010387 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1167634010388 glutathione S-transferase; Provisional; Region: PRK15113 1167634010389 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1167634010390 C-terminal domain interface [polypeptide binding]; other site 1167634010391 GSH binding site (G-site) [chemical binding]; other site 1167634010392 dimer interface [polypeptide binding]; other site 1167634010393 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1167634010394 putative substrate binding pocket (H-site) [chemical binding]; other site 1167634010395 N-terminal domain interface [polypeptide binding]; other site 1167634010396 Cupin domain; Region: Cupin_2; cl17218 1167634010397 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1167634010398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634010399 Coenzyme A binding pocket [chemical binding]; other site 1167634010400 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1167634010401 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1167634010402 HSP70 interaction site [polypeptide binding]; other site 1167634010403 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1167634010404 substrate binding site [polypeptide binding]; other site 1167634010405 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1167634010406 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1167634010407 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634010408 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1167634010409 putative C-terminal domain interface [polypeptide binding]; other site 1167634010410 putative GSH binding site (G-site) [chemical binding]; other site 1167634010411 putative dimer interface [polypeptide binding]; other site 1167634010412 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1167634010413 dimer interface [polypeptide binding]; other site 1167634010414 N-terminal domain interface [polypeptide binding]; other site 1167634010415 putative substrate binding pocket (H-site) [chemical binding]; other site 1167634010416 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1167634010417 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1167634010418 catalytic residues [active] 1167634010419 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1167634010420 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1167634010421 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1167634010422 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1167634010423 MPT binding site; other site 1167634010424 trimer interface [polypeptide binding]; other site 1167634010425 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1167634010426 Peptidase family M23; Region: Peptidase_M23; pfam01551 1167634010427 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1167634010428 rRNA binding site [nucleotide binding]; other site 1167634010429 predicted 30S ribosome binding site; other site 1167634010430 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1167634010431 putative hydrophobic ligand binding site [chemical binding]; other site 1167634010432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634010433 dimerization interface [polypeptide binding]; other site 1167634010434 putative DNA binding site [nucleotide binding]; other site 1167634010435 putative Zn2+ binding site [ion binding]; other site 1167634010436 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1167634010437 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1167634010438 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1167634010439 Walker A/P-loop; other site 1167634010440 ATP binding site [chemical binding]; other site 1167634010441 Q-loop/lid; other site 1167634010442 ABC transporter signature motif; other site 1167634010443 Walker B; other site 1167634010444 D-loop; other site 1167634010445 H-loop/switch region; other site 1167634010446 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1167634010447 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1167634010448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634010449 dimer interface [polypeptide binding]; other site 1167634010450 conserved gate region; other site 1167634010451 ABC-ATPase subunit interface; other site 1167634010452 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634010453 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1167634010454 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1167634010455 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1167634010456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634010457 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634010458 dimerization interface [polypeptide binding]; other site 1167634010459 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1167634010460 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 1167634010461 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634010462 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1167634010463 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634010464 active site 1167634010465 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 1167634010466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634010467 DNA-binding site [nucleotide binding]; DNA binding site 1167634010468 UTRA domain; Region: UTRA; pfam07702 1167634010469 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1167634010470 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 1167634010471 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 1167634010472 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 1167634010473 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1167634010474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634010475 Walker A/P-loop; other site 1167634010476 ATP binding site [chemical binding]; other site 1167634010477 Q-loop/lid; other site 1167634010478 ABC transporter signature motif; other site 1167634010479 Walker B; other site 1167634010480 D-loop; other site 1167634010481 H-loop/switch region; other site 1167634010482 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634010483 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1167634010484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634010485 Walker A/P-loop; other site 1167634010486 ATP binding site [chemical binding]; other site 1167634010487 Q-loop/lid; other site 1167634010488 ABC transporter signature motif; other site 1167634010489 Walker B; other site 1167634010490 D-loop; other site 1167634010491 H-loop/switch region; other site 1167634010492 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1167634010493 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1167634010494 active site 1167634010495 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1167634010496 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1167634010497 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1167634010498 Strictosidine synthase; Region: Str_synth; pfam03088 1167634010499 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1167634010500 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1167634010501 intersubunit interface [polypeptide binding]; other site 1167634010502 active site 1167634010503 zinc binding site [ion binding]; other site 1167634010504 Na+ binding site [ion binding]; other site 1167634010505 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1167634010506 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1167634010507 ATP binding site [chemical binding]; other site 1167634010508 active site 1167634010509 substrate binding site [chemical binding]; other site 1167634010510 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1167634010511 AIR carboxylase; Region: AIRC; pfam00731 1167634010512 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1167634010513 ATP-grasp domain; Region: ATP-grasp; pfam02222 1167634010514 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1167634010515 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1167634010516 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1167634010517 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1167634010518 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634010519 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1167634010520 Coenzyme A transferase; Region: CoA_trans; cl17247 1167634010521 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634010522 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1167634010523 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634010524 substrate binding pocket [chemical binding]; other site 1167634010525 membrane-bound complex binding site; other site 1167634010526 hinge residues; other site 1167634010527 hypothetical protein; Validated; Region: PRK07586 1167634010528 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1167634010529 PYR/PP interface [polypeptide binding]; other site 1167634010530 dimer interface [polypeptide binding]; other site 1167634010531 TPP binding site [chemical binding]; other site 1167634010532 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1167634010533 TPP-binding site [chemical binding]; other site 1167634010534 dimer interface [polypeptide binding]; other site 1167634010535 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634010536 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634010537 Walker A/P-loop; other site 1167634010538 ATP binding site [chemical binding]; other site 1167634010539 Q-loop/lid; other site 1167634010540 ABC transporter signature motif; other site 1167634010541 Walker B; other site 1167634010542 D-loop; other site 1167634010543 H-loop/switch region; other site 1167634010544 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634010545 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634010546 Walker A/P-loop; other site 1167634010547 ATP binding site [chemical binding]; other site 1167634010548 Q-loop/lid; other site 1167634010549 ABC transporter signature motif; other site 1167634010550 Walker B; other site 1167634010551 D-loop; other site 1167634010552 H-loop/switch region; other site 1167634010553 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634010554 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634010555 TM-ABC transporter signature motif; other site 1167634010556 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634010557 TM-ABC transporter signature motif; other site 1167634010558 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634010559 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 1167634010560 putative ligand binding site [chemical binding]; other site 1167634010561 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634010562 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 1167634010563 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634010564 acyl-activating enzyme (AAE) consensus motif; other site 1167634010565 AMP binding site [chemical binding]; other site 1167634010566 active site 1167634010567 CoA binding site [chemical binding]; other site 1167634010568 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 1167634010569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634010570 non-specific DNA binding site [nucleotide binding]; other site 1167634010571 salt bridge; other site 1167634010572 sequence-specific DNA binding site [nucleotide binding]; other site 1167634010573 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1167634010574 ADP binding site [chemical binding]; other site 1167634010575 magnesium binding site [ion binding]; other site 1167634010576 putative shikimate binding site; other site 1167634010577 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 1167634010578 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634010579 substrate binding site [chemical binding]; other site 1167634010580 oxyanion hole (OAH) forming residues; other site 1167634010581 trimer interface [polypeptide binding]; other site 1167634010582 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634010583 oxyanion hole (OAH) forming residues; other site 1167634010584 trimer interface [polypeptide binding]; other site 1167634010585 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 1167634010586 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 1167634010587 4Fe-4S binding domain; Region: Fer4; pfam00037 1167634010588 4Fe-4S binding domain; Region: Fer4; pfam00037 1167634010589 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 1167634010590 dimerization interface [polypeptide binding]; other site 1167634010591 FAD binding pocket [chemical binding]; other site 1167634010592 FAD binding motif [chemical binding]; other site 1167634010593 catalytic residues [active] 1167634010594 NAD binding pocket [chemical binding]; other site 1167634010595 phosphate binding motif [ion binding]; other site 1167634010596 beta-alpha-beta structure motif; other site 1167634010597 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1167634010598 putative active site [active] 1167634010599 putative catalytic site [active] 1167634010600 Phage Tail Collar Domain; Region: Collar; pfam07484 1167634010601 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1167634010602 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1167634010603 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1167634010604 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634010605 FAD binding site [chemical binding]; other site 1167634010606 substrate binding pocket [chemical binding]; other site 1167634010607 catalytic base [active] 1167634010608 thiamine pyrophosphate protein; Validated; Region: PRK08199 1167634010609 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1167634010610 PYR/PP interface [polypeptide binding]; other site 1167634010611 dimer interface [polypeptide binding]; other site 1167634010612 TPP binding site [chemical binding]; other site 1167634010613 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1167634010614 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1167634010615 TPP-binding site [chemical binding]; other site 1167634010616 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1167634010617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634010618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634010619 dimerization interface [polypeptide binding]; other site 1167634010620 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1167634010621 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1167634010622 active site 1167634010623 DNA binding site [nucleotide binding] 1167634010624 Int/Topo IB signature motif; other site 1167634010625 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1167634010626 putative deacylase active site [active] 1167634010627 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1167634010628 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1167634010629 conserved cys residue [active] 1167634010630 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1167634010631 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1167634010632 NAD binding site [chemical binding]; other site 1167634010633 substrate binding site [chemical binding]; other site 1167634010634 catalytic Zn binding site [ion binding]; other site 1167634010635 tetramer interface [polypeptide binding]; other site 1167634010636 structural Zn binding site [ion binding]; other site 1167634010637 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 1167634010638 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1167634010639 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1167634010640 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1167634010641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634010642 substrate binding site [chemical binding]; other site 1167634010643 oxyanion hole (OAH) forming residues; other site 1167634010644 trimer interface [polypeptide binding]; other site 1167634010645 AMP-binding domain protein; Validated; Region: PRK08315 1167634010646 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634010647 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1167634010648 acyl-activating enzyme (AAE) consensus motif; other site 1167634010649 acyl-activating enzyme (AAE) consensus motif; other site 1167634010650 putative AMP binding site [chemical binding]; other site 1167634010651 putative active site [active] 1167634010652 putative CoA binding site [chemical binding]; other site 1167634010653 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1167634010654 active site 1167634010655 catalytic residues [active] 1167634010656 metal binding site [ion binding]; metal-binding site 1167634010657 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1167634010658 MarR family; Region: MarR_2; pfam12802 1167634010659 MarR family; Region: MarR_2; cl17246 1167634010660 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 1167634010661 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634010662 substrate binding site [chemical binding]; other site 1167634010663 oxyanion hole (OAH) forming residues; other site 1167634010664 trimer interface [polypeptide binding]; other site 1167634010665 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634010666 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634010667 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634010668 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1167634010669 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1167634010670 oligomeric interface; other site 1167634010671 putative active site [active] 1167634010672 homodimer interface [polypeptide binding]; other site 1167634010673 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1167634010674 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1167634010675 FMN binding site [chemical binding]; other site 1167634010676 substrate binding site [chemical binding]; other site 1167634010677 putative catalytic residue [active] 1167634010678 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1167634010679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634010680 putative substrate translocation pore; other site 1167634010681 probable DNA repair protein; Region: TIGR03623 1167634010682 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1167634010683 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1167634010684 Part of AAA domain; Region: AAA_19; pfam13245 1167634010685 Family description; Region: UvrD_C_2; pfam13538 1167634010686 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1167634010687 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1167634010688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634010689 Walker A motif; other site 1167634010690 ATP binding site [chemical binding]; other site 1167634010691 Walker B motif; other site 1167634010692 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1167634010693 arginine finger; other site 1167634010694 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1167634010695 hypothetical protein; Validated; Region: PRK00153 1167634010696 recombination protein RecR; Reviewed; Region: recR; PRK00076 1167634010697 RecR protein; Region: RecR; pfam02132 1167634010698 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1167634010699 putative active site [active] 1167634010700 putative metal-binding site [ion binding]; other site 1167634010701 tetramer interface [polypeptide binding]; other site 1167634010702 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634010703 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634010704 NMT1-like family; Region: NMT1_2; pfam13379 1167634010705 NMT1/THI5 like; Region: NMT1; pfam09084 1167634010706 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1167634010707 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634010708 Walker A/P-loop; other site 1167634010709 ATP binding site [chemical binding]; other site 1167634010710 Q-loop/lid; other site 1167634010711 ABC transporter signature motif; other site 1167634010712 Walker B; other site 1167634010713 D-loop; other site 1167634010714 H-loop/switch region; other site 1167634010715 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634010716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634010717 dimer interface [polypeptide binding]; other site 1167634010718 conserved gate region; other site 1167634010719 putative PBP binding loops; other site 1167634010720 ABC-ATPase subunit interface; other site 1167634010721 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 1167634010722 heme binding pocket [chemical binding]; other site 1167634010723 heme ligand [chemical binding]; other site 1167634010724 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634010725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634010726 active site 1167634010727 phosphorylation site [posttranslational modification] 1167634010728 intermolecular recognition site; other site 1167634010729 dimerization interface [polypeptide binding]; other site 1167634010730 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 1167634010731 GAF domain; Region: GAF; pfam01590 1167634010732 Phytochrome region; Region: PHY; pfam00360 1167634010733 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634010734 dimer interface [polypeptide binding]; other site 1167634010735 phosphorylation site [posttranslational modification] 1167634010736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634010737 ATP binding site [chemical binding]; other site 1167634010738 Mg2+ binding site [ion binding]; other site 1167634010739 G-X-G motif; other site 1167634010740 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1167634010741 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1167634010742 transaldolase-like protein; Provisional; Region: PTZ00411 1167634010743 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1167634010744 active site 1167634010745 dimer interface [polypeptide binding]; other site 1167634010746 catalytic residue [active] 1167634010747 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1167634010748 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1167634010749 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1167634010750 catalytic site [active] 1167634010751 subunit interface [polypeptide binding]; other site 1167634010752 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1167634010753 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1167634010754 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1167634010755 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1167634010756 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1167634010757 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1167634010758 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1167634010759 IMP binding site; other site 1167634010760 dimer interface [polypeptide binding]; other site 1167634010761 interdomain contacts; other site 1167634010762 partial ornithine binding site; other site 1167634010763 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1167634010764 short chain dehydrogenase; Provisional; Region: PRK07024 1167634010765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634010766 NAD(P) binding site [chemical binding]; other site 1167634010767 active site 1167634010768 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1167634010769 catalytic core [active] 1167634010770 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634010771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634010772 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634010773 dimerization interface [polypeptide binding]; other site 1167634010774 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1167634010775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634010776 Walker A/P-loop; other site 1167634010777 ATP binding site [chemical binding]; other site 1167634010778 Q-loop/lid; other site 1167634010779 ABC transporter signature motif; other site 1167634010780 Walker B; other site 1167634010781 D-loop; other site 1167634010782 H-loop/switch region; other site 1167634010783 TOBE domain; Region: TOBE_2; pfam08402 1167634010784 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1167634010785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634010786 dimer interface [polypeptide binding]; other site 1167634010787 conserved gate region; other site 1167634010788 putative PBP binding loops; other site 1167634010789 ABC-ATPase subunit interface; other site 1167634010790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634010791 dimer interface [polypeptide binding]; other site 1167634010792 conserved gate region; other site 1167634010793 putative PBP binding loops; other site 1167634010794 ABC-ATPase subunit interface; other site 1167634010795 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1167634010796 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1167634010797 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1167634010798 ligand binding site [chemical binding]; other site 1167634010799 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634010800 dimerization interface [polypeptide binding]; other site 1167634010801 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634010802 dimer interface [polypeptide binding]; other site 1167634010803 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1167634010804 putative CheW interface [polypeptide binding]; other site 1167634010805 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1167634010806 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1167634010807 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1167634010808 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 1167634010809 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1167634010810 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1167634010811 FtsH Extracellular; Region: FtsH_ext; pfam06480 1167634010812 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1167634010813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634010814 Walker A motif; other site 1167634010815 ATP binding site [chemical binding]; other site 1167634010816 Walker B motif; other site 1167634010817 arginine finger; other site 1167634010818 Peptidase family M41; Region: Peptidase_M41; pfam01434 1167634010819 dihydropteroate synthase; Region: DHPS; TIGR01496 1167634010820 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1167634010821 substrate binding pocket [chemical binding]; other site 1167634010822 dimer interface [polypeptide binding]; other site 1167634010823 inhibitor binding site; inhibition site 1167634010824 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1167634010825 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1167634010826 active site 1167634010827 substrate binding site [chemical binding]; other site 1167634010828 metal binding site [ion binding]; metal-binding site 1167634010829 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1167634010830 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1167634010831 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1167634010832 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 1167634010833 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1167634010834 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1167634010835 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1167634010836 putative active site [active] 1167634010837 catalytic site [active] 1167634010838 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1167634010839 putative domain interface [polypeptide binding]; other site 1167634010840 putative active site [active] 1167634010841 catalytic site [active] 1167634010842 PBP superfamily domain; Region: PBP_like_2; cl17296 1167634010843 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1167634010844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634010845 dimer interface [polypeptide binding]; other site 1167634010846 conserved gate region; other site 1167634010847 putative PBP binding loops; other site 1167634010848 ABC-ATPase subunit interface; other site 1167634010849 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1167634010850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634010851 dimer interface [polypeptide binding]; other site 1167634010852 conserved gate region; other site 1167634010853 putative PBP binding loops; other site 1167634010854 ABC-ATPase subunit interface; other site 1167634010855 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1167634010856 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1167634010857 Walker A/P-loop; other site 1167634010858 ATP binding site [chemical binding]; other site 1167634010859 Q-loop/lid; other site 1167634010860 ABC transporter signature motif; other site 1167634010861 Walker B; other site 1167634010862 D-loop; other site 1167634010863 H-loop/switch region; other site 1167634010864 benzoate transport; Region: 2A0115; TIGR00895 1167634010865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634010866 putative substrate translocation pore; other site 1167634010867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634010868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1167634010869 ATP binding site [chemical binding]; other site 1167634010870 putative Mg++ binding site [ion binding]; other site 1167634010871 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1167634010872 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634010873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634010874 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1167634010875 putative effector binding pocket; other site 1167634010876 putative dimerization interface [polypeptide binding]; other site 1167634010877 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1167634010878 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1167634010879 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1167634010880 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1167634010881 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1167634010882 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1167634010883 classical (c) SDRs; Region: SDR_c; cd05233 1167634010884 NAD(P) binding site [chemical binding]; other site 1167634010885 active site 1167634010886 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1167634010887 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1167634010888 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634010889 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634010890 active site 1167634010891 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634010892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634010893 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1167634010894 active site 2 [active] 1167634010895 active site 1 [active] 1167634010896 thiolase; Provisional; Region: PRK06158 1167634010897 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1167634010898 active site 1167634010899 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1167634010900 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1167634010901 DUF35 OB-fold domain; Region: DUF35; pfam01796 1167634010902 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634010903 phenylacetate degradation probable enoyl-CoA hydratase paaB; Region: PaaB1; TIGR02280 1167634010904 substrate binding site [chemical binding]; other site 1167634010905 oxyanion hole (OAH) forming residues; other site 1167634010906 trimer interface [polypeptide binding]; other site 1167634010907 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1167634010908 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634010909 substrate binding site [chemical binding]; other site 1167634010910 oxyanion hole (OAH) forming residues; other site 1167634010911 trimer interface [polypeptide binding]; other site 1167634010912 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 1167634010913 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634010914 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634010915 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1167634010916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634010917 Walker A motif; other site 1167634010918 ATP binding site [chemical binding]; other site 1167634010919 Walker B motif; other site 1167634010920 arginine finger; other site 1167634010921 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1167634010922 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634010923 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634010924 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634010925 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1167634010926 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634010927 NAD(P) binding site [chemical binding]; other site 1167634010928 substrate binding site [chemical binding]; other site 1167634010929 homotetramer interface [polypeptide binding]; other site 1167634010930 active site 1167634010931 homodimer interface [polypeptide binding]; other site 1167634010932 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634010933 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1167634010934 putative ligand binding site [chemical binding]; other site 1167634010935 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1167634010936 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1167634010937 NAD(P) binding site [chemical binding]; other site 1167634010938 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634010939 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634010940 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634010941 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1167634010942 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1167634010943 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634010944 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634010945 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634010946 active site 1167634010947 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634010948 classical (c) SDRs; Region: SDR_c; cd05233 1167634010949 NAD(P) binding site [chemical binding]; other site 1167634010950 active site 1167634010951 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634010952 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1167634010953 substrate binding site [chemical binding]; other site 1167634010954 oxyanion hole (OAH) forming residues; other site 1167634010955 trimer interface [polypeptide binding]; other site 1167634010956 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1167634010957 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634010958 acyl-activating enzyme (AAE) consensus motif; other site 1167634010959 AMP binding site [chemical binding]; other site 1167634010960 active site 1167634010961 CoA binding site [chemical binding]; other site 1167634010962 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1167634010963 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634010964 substrate binding site [chemical binding]; other site 1167634010965 oxyanion hole (OAH) forming residues; other site 1167634010966 trimer interface [polypeptide binding]; other site 1167634010967 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634010968 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634010969 PAS domain; Region: PAS_9; pfam13426 1167634010970 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1167634010971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634010972 Walker A motif; other site 1167634010973 ATP binding site [chemical binding]; other site 1167634010974 Walker B motif; other site 1167634010975 arginine finger; other site 1167634010976 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1167634010977 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634010978 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1167634010979 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1167634010980 active site 1167634010981 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1167634010982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634010983 NAD(P) binding site [chemical binding]; other site 1167634010984 active site 1167634010985 short chain dehydrogenase; Provisional; Region: PRK06172 1167634010986 classical (c) SDRs; Region: SDR_c; cd05233 1167634010987 NAD(P) binding site [chemical binding]; other site 1167634010988 active site 1167634010989 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1167634010990 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1167634010991 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1167634010992 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1167634010993 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1167634010994 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1167634010995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634010996 putative substrate translocation pore; other site 1167634010997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634010998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634010999 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1167634011000 putative effector binding pocket; other site 1167634011001 putative dimerization interface [polypeptide binding]; other site 1167634011002 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1167634011003 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1167634011004 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1167634011005 MPN+ (JAMM) motif; other site 1167634011006 Zinc-binding site [ion binding]; other site 1167634011007 integrase; Provisional; Region: PRK09692 1167634011008 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1167634011009 active site 1167634011010 Int/Topo IB signature motif; other site 1167634011011 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634011012 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1167634011013 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1167634011014 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1167634011015 Lysine efflux permease [General function prediction only]; Region: COG1279 1167634011016 BssS protein family; Region: BssS; cl08210 1167634011017 Protein of unknown function (DUF465); Region: DUF465; cl01070 1167634011018 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1167634011019 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1167634011020 Isochorismatase family; Region: Isochorismatase; pfam00857 1167634011021 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1167634011022 catalytic triad [active] 1167634011023 dimer interface [polypeptide binding]; other site 1167634011024 conserved cis-peptide bond; other site 1167634011025 LysR family transcriptional regulator; Provisional; Region: PRK14997 1167634011026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634011027 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1167634011028 putative effector binding pocket; other site 1167634011029 putative dimerization interface [polypeptide binding]; other site 1167634011030 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1167634011031 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634011032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634011033 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1167634011034 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1167634011035 active site 1167634011036 catalytic tetrad [active] 1167634011037 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1167634011038 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1167634011039 Fasciclin domain; Region: Fasciclin; pfam02469 1167634011040 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1167634011041 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 1167634011042 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1167634011043 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1167634011044 catalytic residue [active] 1167634011045 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1167634011046 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1167634011047 substrate binding site [chemical binding]; other site 1167634011048 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1167634011049 substrate binding site [chemical binding]; other site 1167634011050 ligand binding site [chemical binding]; other site 1167634011051 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1167634011052 FOG: CBS domain [General function prediction only]; Region: COG0517 1167634011053 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1167634011054 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1167634011055 Proline racemase; Region: Pro_racemase; pfam05544 1167634011056 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1167634011057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634011058 dimer interface [polypeptide binding]; other site 1167634011059 conserved gate region; other site 1167634011060 putative PBP binding loops; other site 1167634011061 ABC-ATPase subunit interface; other site 1167634011062 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1167634011063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634011064 dimer interface [polypeptide binding]; other site 1167634011065 conserved gate region; other site 1167634011066 putative PBP binding loops; other site 1167634011067 ABC-ATPase subunit interface; other site 1167634011068 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1167634011069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634011070 Walker A/P-loop; other site 1167634011071 ATP binding site [chemical binding]; other site 1167634011072 Q-loop/lid; other site 1167634011073 ABC transporter signature motif; other site 1167634011074 Walker B; other site 1167634011075 D-loop; other site 1167634011076 H-loop/switch region; other site 1167634011077 TOBE domain; Region: TOBE_2; pfam08402 1167634011078 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1167634011079 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1167634011080 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1167634011081 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1167634011082 conserved cys residue [active] 1167634011083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634011084 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 1167634011085 glutathione s-transferase; Provisional; Region: PTZ00057 1167634011086 GSH binding site (G-site) [chemical binding]; other site 1167634011087 C-terminal domain interface [polypeptide binding]; other site 1167634011088 dimer interface [polypeptide binding]; other site 1167634011089 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 1167634011090 dimer interface [polypeptide binding]; other site 1167634011091 N-terminal domain interface [polypeptide binding]; other site 1167634011092 substrate binding pocket (H-site) [chemical binding]; other site 1167634011093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634011094 PAS domain; Region: PAS_9; pfam13426 1167634011095 putative active site [active] 1167634011096 heme pocket [chemical binding]; other site 1167634011097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634011098 PAS domain; Region: PAS_9; pfam13426 1167634011099 putative active site [active] 1167634011100 heme pocket [chemical binding]; other site 1167634011101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634011102 dimer interface [polypeptide binding]; other site 1167634011103 putative CheW interface [polypeptide binding]; other site 1167634011104 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1167634011105 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1167634011106 active site 1167634011107 catalytic site [active] 1167634011108 substrate binding site [chemical binding]; other site 1167634011109 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1167634011110 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1167634011111 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 1167634011112 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1167634011113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634011114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634011115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634011116 dimerization interface [polypeptide binding]; other site 1167634011117 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1167634011118 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1167634011119 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1167634011120 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1167634011121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634011122 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1167634011123 dimerization interface [polypeptide binding]; other site 1167634011124 substrate binding pocket [chemical binding]; other site 1167634011125 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1167634011126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634011127 active site 1167634011128 phosphorylation site [posttranslational modification] 1167634011129 intermolecular recognition site; other site 1167634011130 dimerization interface [polypeptide binding]; other site 1167634011131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634011132 Walker A motif; other site 1167634011133 ATP binding site [chemical binding]; other site 1167634011134 Walker B motif; other site 1167634011135 arginine finger; other site 1167634011136 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1167634011137 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1167634011138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634011139 phosphorylation site [posttranslational modification] 1167634011140 dimer interface [polypeptide binding]; other site 1167634011141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634011142 ATP binding site [chemical binding]; other site 1167634011143 Mg2+ binding site [ion binding]; other site 1167634011144 G-X-G motif; other site 1167634011145 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1167634011146 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1167634011147 Maf-like protein; Provisional; Region: PRK14361 1167634011148 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1167634011149 active site 1167634011150 dimer interface [polypeptide binding]; other site 1167634011151 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1167634011152 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1167634011153 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1167634011154 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1167634011155 active site 1167634011156 (T/H)XGH motif; other site 1167634011157 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1167634011158 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1167634011159 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1167634011160 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1167634011161 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1167634011162 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1167634011163 hypothetical protein; Validated; Region: PRK00110 1167634011164 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1167634011165 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1167634011166 Walker A motif; other site 1167634011167 ATP binding site [chemical binding]; other site 1167634011168 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1167634011169 tartrate dehydrogenase; Region: TTC; TIGR02089 1167634011170 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1167634011171 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1167634011172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634011173 putative substrate translocation pore; other site 1167634011174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634011175 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1167634011176 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634011177 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634011178 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1167634011179 MarR family; Region: MarR_2; cl17246 1167634011180 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1167634011181 EamA-like transporter family; Region: EamA; cl17759 1167634011182 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1167634011183 EamA-like transporter family; Region: EamA; pfam00892 1167634011184 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634011185 EamA-like transporter family; Region: EamA; pfam00892 1167634011186 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1167634011187 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1167634011188 NADP binding site [chemical binding]; other site 1167634011189 dimer interface [polypeptide binding]; other site 1167634011190 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1167634011191 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1167634011192 NAD(P) binding site [chemical binding]; other site 1167634011193 catalytic residues [active] 1167634011194 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1167634011195 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 1167634011196 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1167634011197 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1167634011198 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 1167634011199 Helix-turn-helix domain; Region: HTH_18; pfam12833 1167634011200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634011201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1167634011202 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1167634011203 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1167634011204 metal binding triad; other site 1167634011205 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1167634011206 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1167634011207 metal binding triad; other site 1167634011208 TIGR02099 family protein; Region: TIGR02099 1167634011209 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1167634011210 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1167634011211 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1167634011212 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1167634011213 RNA binding site [nucleotide binding]; other site 1167634011214 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1167634011215 multimer interface [polypeptide binding]; other site 1167634011216 Walker A motif; other site 1167634011217 ATP binding site [chemical binding]; other site 1167634011218 Walker B motif; other site 1167634011219 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1167634011220 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1167634011221 catalytic residues [active] 1167634011222 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1167634011223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634011224 ATP binding site [chemical binding]; other site 1167634011225 Mg2+ binding site [ion binding]; other site 1167634011226 G-X-G motif; other site 1167634011227 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1167634011228 anchoring element; other site 1167634011229 dimer interface [polypeptide binding]; other site 1167634011230 ATP binding site [chemical binding]; other site 1167634011231 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1167634011232 active site 1167634011233 metal binding site [ion binding]; metal-binding site 1167634011234 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1167634011235 YcxB-like protein; Region: YcxB; pfam14317 1167634011236 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1167634011237 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1167634011238 CAP-like domain; other site 1167634011239 active site 1167634011240 primary dimer interface [polypeptide binding]; other site 1167634011241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634011242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634011243 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1167634011244 hypothetical protein; Provisional; Region: PRK07483 1167634011245 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1167634011246 inhibitor-cofactor binding pocket; inhibition site 1167634011247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634011248 catalytic residue [active] 1167634011249 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1167634011250 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1167634011251 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1167634011252 putative active site [active] 1167634011253 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1167634011254 MarR family; Region: MarR; pfam01047 1167634011255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1167634011256 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1167634011257 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1167634011258 inhibitor-cofactor binding pocket; inhibition site 1167634011259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634011260 catalytic residue [active] 1167634011261 Ectoine synthase; Region: Ectoine_synth; pfam06339 1167634011262 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1167634011263 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1167634011264 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1167634011265 MOSC domain; Region: MOSC; pfam03473 1167634011266 multidrug efflux system protein; Provisional; Region: PRK11431 1167634011267 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1167634011268 tetramerization interface [polypeptide binding]; other site 1167634011269 active site 1167634011270 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1167634011271 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1167634011272 catalytic loop [active] 1167634011273 iron binding site [ion binding]; other site 1167634011274 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1167634011275 FAD binding pocket [chemical binding]; other site 1167634011276 FAD binding motif [chemical binding]; other site 1167634011277 phosphate binding motif [ion binding]; other site 1167634011278 beta-alpha-beta structure motif; other site 1167634011279 NAD binding pocket [chemical binding]; other site 1167634011280 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1167634011281 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634011282 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1167634011283 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1167634011284 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1167634011285 VirB7 interaction site; other site 1167634011286 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1167634011287 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1167634011288 motif 1; other site 1167634011289 active site 1167634011290 motif 2; other site 1167634011291 motif 3; other site 1167634011292 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1167634011293 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1167634011294 CPxP motif; other site 1167634011295 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1167634011296 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1167634011297 RimM N-terminal domain; Region: RimM; pfam01782 1167634011298 PRC-barrel domain; Region: PRC; pfam05239 1167634011299 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1167634011300 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1167634011301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634011302 non-specific DNA binding site [nucleotide binding]; other site 1167634011303 salt bridge; other site 1167634011304 sequence-specific DNA binding site [nucleotide binding]; other site 1167634011305 Cupin domain; Region: Cupin_2; pfam07883 1167634011306 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634011307 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634011308 substrate binding pocket [chemical binding]; other site 1167634011309 membrane-bound complex binding site; other site 1167634011310 hinge residues; other site 1167634011311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634011312 dimer interface [polypeptide binding]; other site 1167634011313 conserved gate region; other site 1167634011314 putative PBP binding loops; other site 1167634011315 ABC-ATPase subunit interface; other site 1167634011316 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634011317 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634011318 Walker A/P-loop; other site 1167634011319 ATP binding site [chemical binding]; other site 1167634011320 Q-loop/lid; other site 1167634011321 ABC transporter signature motif; other site 1167634011322 Walker B; other site 1167634011323 D-loop; other site 1167634011324 H-loop/switch region; other site 1167634011325 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634011326 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1167634011327 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1167634011328 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1167634011329 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1167634011330 HIGH motif; other site 1167634011331 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1167634011332 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1167634011333 active site 1167634011334 KMSKS motif; other site 1167634011335 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1167634011336 tRNA binding surface [nucleotide binding]; other site 1167634011337 anticodon binding site; other site 1167634011338 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1167634011339 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1167634011340 active site 1167634011341 multimer interface [polypeptide binding]; other site 1167634011342 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1167634011343 Helix-turn-helix domain; Region: HTH_25; pfam13413 1167634011344 non-specific DNA binding site [nucleotide binding]; other site 1167634011345 salt bridge; other site 1167634011346 sequence-specific DNA binding site [nucleotide binding]; other site 1167634011347 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1167634011348 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1167634011349 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1167634011350 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1167634011351 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1167634011352 dimer interface [polypeptide binding]; other site 1167634011353 motif 1; other site 1167634011354 active site 1167634011355 motif 2; other site 1167634011356 motif 3; other site 1167634011357 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1167634011358 anticodon binding site; other site 1167634011359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1167634011360 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1167634011361 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1167634011362 Trp docking motif [polypeptide binding]; other site 1167634011363 active site 1167634011364 GTP-binding protein Der; Reviewed; Region: PRK00093 1167634011365 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1167634011366 G1 box; other site 1167634011367 GTP/Mg2+ binding site [chemical binding]; other site 1167634011368 Switch I region; other site 1167634011369 G2 box; other site 1167634011370 Switch II region; other site 1167634011371 G3 box; other site 1167634011372 G4 box; other site 1167634011373 G5 box; other site 1167634011374 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1167634011375 G1 box; other site 1167634011376 GTP/Mg2+ binding site [chemical binding]; other site 1167634011377 Switch I region; other site 1167634011378 G2 box; other site 1167634011379 G3 box; other site 1167634011380 Switch II region; other site 1167634011381 G4 box; other site 1167634011382 G5 box; other site 1167634011383 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1167634011384 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634011385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634011386 homodimer interface [polypeptide binding]; other site 1167634011387 catalytic residue [active] 1167634011388 bacterial Hfq-like; Region: Hfq; cd01716 1167634011389 hexamer interface [polypeptide binding]; other site 1167634011390 Sm1 motif; other site 1167634011391 RNA binding site [nucleotide binding]; other site 1167634011392 Sm2 motif; other site 1167634011393 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1167634011394 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1167634011395 HflX GTPase family; Region: HflX; cd01878 1167634011396 G1 box; other site 1167634011397 GTP/Mg2+ binding site [chemical binding]; other site 1167634011398 Switch I region; other site 1167634011399 G2 box; other site 1167634011400 G3 box; other site 1167634011401 Switch II region; other site 1167634011402 G4 box; other site 1167634011403 G5 box; other site 1167634011404 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1167634011405 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1167634011406 HflK protein; Region: hflK; TIGR01933 1167634011407 HflC protein; Region: hflC; TIGR01932 1167634011408 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1167634011409 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1167634011410 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1167634011411 dimer interface [polypeptide binding]; other site 1167634011412 motif 1; other site 1167634011413 active site 1167634011414 motif 2; other site 1167634011415 motif 3; other site 1167634011416 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1167634011417 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1167634011418 GDP-binding site [chemical binding]; other site 1167634011419 ACT binding site; other site 1167634011420 IMP binding site; other site 1167634011421 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1167634011422 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1167634011423 active site 1167634011424 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1167634011425 DNA primase, catalytic core; Region: dnaG; TIGR01391 1167634011426 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1167634011427 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1167634011428 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1167634011429 active site 1167634011430 metal binding site [ion binding]; metal-binding site 1167634011431 interdomain interaction site; other site 1167634011432 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1167634011433 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1167634011434 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1167634011435 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1167634011436 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1167634011437 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1167634011438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634011439 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1167634011440 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634011441 DNA binding residues [nucleotide binding] 1167634011442 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1167634011443 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634011444 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1167634011445 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1167634011446 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1167634011447 ParB-like nuclease domain; Region: ParBc; cl02129 1167634011448 RecT family; Region: RecT; cl04285 1167634011449 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1167634011450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1167634011451 Walker A/P-loop; other site 1167634011452 ATP binding site [chemical binding]; other site 1167634011453 ABC transporter signature motif; other site 1167634011454 Walker B; other site 1167634011455 D-loop; other site 1167634011456 H-loop/switch region; other site 1167634011457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634011458 Coenzyme A binding pocket [chemical binding]; other site 1167634011459 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1167634011460 active site 1167634011461 substrate binding site [chemical binding]; other site 1167634011462 cosubstrate binding site; other site 1167634011463 catalytic site [active] 1167634011464 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 1167634011465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 1167634011466 Terminase-like family; Region: Terminase_6; pfam03237 1167634011467 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1167634011468 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1167634011469 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1167634011470 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1167634011471 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1167634011472 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1167634011473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 1167634011474 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 1167634011475 LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cl06998 1167634011476 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 1167634011477 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1167634011478 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 1167634011479 Phage-related minor tail protein [Function unknown]; Region: COG5281 1167634011480 tape measure domain; Region: tape_meas_nterm; TIGR02675 1167634011481 Baseplate J-like protein; Region: Baseplate_J; cl01294 1167634011482 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1167634011483 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1167634011484 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1167634011485 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1167634011486 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1167634011487 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1167634011488 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1167634011489 phosphopeptide binding site; other site 1167634011490 Type II/IV secretion system protein; Region: T2SE; pfam00437 1167634011491 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1167634011492 ATP binding site [chemical binding]; other site 1167634011493 Walker A motif; other site 1167634011494 hexamer interface [polypeptide binding]; other site 1167634011495 Walker B motif; other site 1167634011496 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1167634011497 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1167634011498 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1167634011499 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1167634011500 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1167634011501 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1167634011502 putative active site [active] 1167634011503 putative substrate binding site [chemical binding]; other site 1167634011504 ATP binding site [chemical binding]; other site 1167634011505 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 1167634011506 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1167634011507 FMN binding site [chemical binding]; other site 1167634011508 active site 1167634011509 catalytic residues [active] 1167634011510 substrate binding site [chemical binding]; other site 1167634011511 FOG: CBS domain [General function prediction only]; Region: COG0517 1167634011512 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625 1167634011513 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 1167634011514 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1167634011515 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 1167634011516 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1167634011517 hypothetical protein; Validated; Region: PRK00029 1167634011518 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634011519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634011520 active site 1167634011521 phosphorylation site [posttranslational modification] 1167634011522 intermolecular recognition site; other site 1167634011523 dimerization interface [polypeptide binding]; other site 1167634011524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634011525 DNA binding site [nucleotide binding] 1167634011526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634011527 dimer interface [polypeptide binding]; other site 1167634011528 phosphorylation site [posttranslational modification] 1167634011529 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1167634011530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634011531 ATP binding site [chemical binding]; other site 1167634011532 Mg2+ binding site [ion binding]; other site 1167634011533 G-X-G motif; other site 1167634011534 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634011535 metal binding site [ion binding]; metal-binding site 1167634011536 active site 1167634011537 I-site; other site 1167634011538 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634011539 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634011540 I-site; other site 1167634011541 active site 1167634011542 metal binding site [ion binding]; metal-binding site 1167634011543 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634011544 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1167634011545 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1167634011546 Tetramer interface [polypeptide binding]; other site 1167634011547 active site 1167634011548 FMN-binding site [chemical binding]; other site 1167634011549 Peptidase family M48; Region: Peptidase_M48; pfam01435 1167634011550 regulatory protein CsrD; Provisional; Region: PRK11059 1167634011551 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634011552 metal binding site [ion binding]; metal-binding site 1167634011553 active site 1167634011554 I-site; other site 1167634011555 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634011556 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 1167634011557 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011558 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011559 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011560 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011561 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011562 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011563 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011564 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011565 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011566 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011567 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011568 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011569 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011570 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011571 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011572 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1167634011573 metal ion-dependent adhesion site (MIDAS); other site 1167634011574 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1167634011575 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011576 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011577 VCBS repeat; Region: VCBS_repeat; TIGR01965 1167634011578 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634011579 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634011580 DNA binding residues [nucleotide binding] 1167634011581 dimerization interface [polypeptide binding]; other site 1167634011582 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1167634011583 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634011584 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634011585 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 1167634011586 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1167634011587 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634011588 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1167634011589 Walker A/P-loop; other site 1167634011590 ATP binding site [chemical binding]; other site 1167634011591 Q-loop/lid; other site 1167634011592 ABC transporter signature motif; other site 1167634011593 Walker B; other site 1167634011594 D-loop; other site 1167634011595 H-loop/switch region; other site 1167634011596 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1167634011597 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1167634011598 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1167634011599 substrate binding site [chemical binding]; other site 1167634011600 ligand binding site [chemical binding]; other site 1167634011601 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1167634011602 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1167634011603 substrate binding site [chemical binding]; other site 1167634011604 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1167634011605 tartrate dehydrogenase; Region: TTC; TIGR02089 1167634011606 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1167634011607 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1167634011608 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1167634011609 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1167634011610 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1167634011611 dimerization interface 3.5A [polypeptide binding]; other site 1167634011612 active site 1167634011613 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1167634011614 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1167634011615 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1167634011616 active site 1167634011617 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1167634011618 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1167634011619 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1167634011620 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1167634011621 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1167634011622 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1167634011623 CGNR zinc finger; Region: zf-CGNR; pfam11706 1167634011624 TM2 domain; Region: TM2; pfam05154 1167634011625 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1167634011626 Zn2+ binding site [ion binding]; other site 1167634011627 Mg2+ binding site [ion binding]; other site 1167634011628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1167634011629 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 1167634011630 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1167634011631 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1167634011632 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1167634011633 DctM-like transporters; Region: DctM; pfam06808 1167634011634 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1167634011635 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1167634011636 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1167634011637 DNA binding site [nucleotide binding] 1167634011638 domain linker motif; other site 1167634011639 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1167634011640 putative dimerization interface [polypeptide binding]; other site 1167634011641 putative ligand binding site [chemical binding]; other site 1167634011642 EamA-like transporter family; Region: EamA; pfam00892 1167634011643 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634011644 EamA-like transporter family; Region: EamA; pfam00892 1167634011645 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1167634011646 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1167634011647 active site 1167634011648 Zn binding site [ion binding]; other site 1167634011649 Cupin domain; Region: Cupin_2; cl17218 1167634011650 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1167634011651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634011652 Walker A/P-loop; other site 1167634011653 ATP binding site [chemical binding]; other site 1167634011654 Q-loop/lid; other site 1167634011655 ABC transporter signature motif; other site 1167634011656 Walker B; other site 1167634011657 D-loop; other site 1167634011658 H-loop/switch region; other site 1167634011659 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1167634011660 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634011661 Walker A/P-loop; other site 1167634011662 ATP binding site [chemical binding]; other site 1167634011663 Q-loop/lid; other site 1167634011664 ABC transporter signature motif; other site 1167634011665 Walker B; other site 1167634011666 D-loop; other site 1167634011667 H-loop/switch region; other site 1167634011668 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634011669 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1167634011670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634011671 dimer interface [polypeptide binding]; other site 1167634011672 conserved gate region; other site 1167634011673 putative PBP binding loops; other site 1167634011674 ABC-ATPase subunit interface; other site 1167634011675 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634011676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634011677 dimer interface [polypeptide binding]; other site 1167634011678 conserved gate region; other site 1167634011679 putative PBP binding loops; other site 1167634011680 ABC-ATPase subunit interface; other site 1167634011681 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1167634011682 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1167634011683 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1167634011684 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1167634011685 NAD(P) binding site [chemical binding]; other site 1167634011686 catalytic residues [active] 1167634011687 allantoate amidohydrolase; Reviewed; Region: PRK12893 1167634011688 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1167634011689 active site 1167634011690 metal binding site [ion binding]; metal-binding site 1167634011691 dimer interface [polypeptide binding]; other site 1167634011692 thiamine pyrophosphate protein; Validated; Region: PRK08199 1167634011693 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1167634011694 PYR/PP interface [polypeptide binding]; other site 1167634011695 dimer interface [polypeptide binding]; other site 1167634011696 TPP binding site [chemical binding]; other site 1167634011697 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1167634011698 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1167634011699 TPP-binding site [chemical binding]; other site 1167634011700 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1167634011701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634011702 DNA-binding site [nucleotide binding]; DNA binding site 1167634011703 FCD domain; Region: FCD; pfam07729 1167634011704 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1167634011705 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1167634011706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1167634011707 FeS/SAM binding site; other site 1167634011708 HemN C-terminal domain; Region: HemN_C; pfam06969 1167634011709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634011710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634011711 active site 1167634011712 phosphorylation site [posttranslational modification] 1167634011713 intermolecular recognition site; other site 1167634011714 dimerization interface [polypeptide binding]; other site 1167634011715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634011716 DNA binding residues [nucleotide binding] 1167634011717 dimerization interface [polypeptide binding]; other site 1167634011718 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1167634011719 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1167634011720 NADP binding site [chemical binding]; other site 1167634011721 active site 1167634011722 putative substrate binding site [chemical binding]; other site 1167634011723 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1167634011724 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1167634011725 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1167634011726 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1167634011727 active site 1167634011728 dimer interface [polypeptide binding]; other site 1167634011729 motif 1; other site 1167634011730 motif 2; other site 1167634011731 motif 3; other site 1167634011732 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1167634011733 anticodon binding site; other site 1167634011734 translation initiation factor IF-3; Region: infC; TIGR00168 1167634011735 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1167634011736 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1167634011737 glutathione synthetase; Provisional; Region: PRK05246 1167634011738 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1167634011739 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1167634011740 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1167634011741 active pocket/dimerization site; other site 1167634011742 active site 1167634011743 phosphorylation site [posttranslational modification] 1167634011744 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1167634011745 dimerization domain swap beta strand [polypeptide binding]; other site 1167634011746 regulatory protein interface [polypeptide binding]; other site 1167634011747 active site 1167634011748 regulatory phosphorylation site [posttranslational modification]; other site 1167634011749 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1167634011750 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1167634011751 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1167634011752 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1167634011753 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1167634011754 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1167634011755 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1167634011756 Membrane fusogenic activity; Region: BMFP; pfam04380 1167634011757 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1167634011758 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1167634011759 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1167634011760 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1167634011761 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1167634011762 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1167634011763 23S rRNA binding site [nucleotide binding]; other site 1167634011764 L21 binding site [polypeptide binding]; other site 1167634011765 L13 binding site [polypeptide binding]; other site 1167634011766 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1167634011767 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1167634011768 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1167634011769 dimer interface [polypeptide binding]; other site 1167634011770 motif 1; other site 1167634011771 active site 1167634011772 motif 2; other site 1167634011773 motif 3; other site 1167634011774 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1167634011775 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1167634011776 putative tRNA-binding site [nucleotide binding]; other site 1167634011777 B3/4 domain; Region: B3_4; pfam03483 1167634011778 tRNA synthetase B5 domain; Region: B5; smart00874 1167634011779 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1167634011780 dimer interface [polypeptide binding]; other site 1167634011781 motif 1; other site 1167634011782 motif 3; other site 1167634011783 motif 2; other site 1167634011784 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1167634011785 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1167634011786 IHF - DNA interface [nucleotide binding]; other site 1167634011787 IHF dimer interface [polypeptide binding]; other site 1167634011788 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1167634011789 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1167634011790 DNA binding residues [nucleotide binding] 1167634011791 outer membrane usher protein; Provisional; Region: PRK15193 1167634011792 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634011793 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1167634011794 NIPSNAP; Region: NIPSNAP; pfam07978 1167634011795 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1167634011796 putative acetyltransferase; Provisional; Region: PRK03624 1167634011797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634011798 Coenzyme A binding pocket [chemical binding]; other site 1167634011799 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1167634011800 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1167634011801 active site 1167634011802 Zn binding site [ion binding]; other site 1167634011803 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634011804 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1167634011805 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1167634011806 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1167634011807 putative active site [active] 1167634011808 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 1167634011809 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634011810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634011811 putative DNA binding site [nucleotide binding]; other site 1167634011812 putative Zn2+ binding site [ion binding]; other site 1167634011813 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634011814 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634011815 EamA-like transporter family; Region: EamA; pfam00892 1167634011816 EamA-like transporter family; Region: EamA; pfam00892 1167634011817 dimerization interface [polypeptide binding]; other site 1167634011818 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1167634011819 putative active cleft [active] 1167634011820 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1167634011821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634011822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634011823 dimerization interface [polypeptide binding]; other site 1167634011824 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634011825 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 1167634011826 NMT1/THI5 like; Region: NMT1; pfam09084 1167634011827 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634011828 substrate binding pocket [chemical binding]; other site 1167634011829 membrane-bound complex binding site; other site 1167634011830 hinge residues; other site 1167634011831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634011832 dimer interface [polypeptide binding]; other site 1167634011833 ABC-ATPase subunit interface; other site 1167634011834 putative PBP binding loops; other site 1167634011835 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634011836 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1167634011837 Walker A/P-loop; other site 1167634011838 ATP binding site [chemical binding]; other site 1167634011839 Q-loop/lid; other site 1167634011840 ABC transporter signature motif; other site 1167634011841 Walker B; other site 1167634011842 D-loop; other site 1167634011843 H-loop/switch region; other site 1167634011844 Cytochrome c; Region: Cytochrom_C; pfam00034 1167634011845 OsmC-like protein; Region: OsmC; pfam02566 1167634011846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634011847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634011848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634011849 dimerization interface [polypeptide binding]; other site 1167634011850 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1167634011851 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1167634011852 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1167634011853 iron-sulfur cluster [ion binding]; other site 1167634011854 [2Fe-2S] cluster binding site [ion binding]; other site 1167634011855 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634011856 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1167634011857 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 1167634011858 Walker A/P-loop; other site 1167634011859 ATP binding site [chemical binding]; other site 1167634011860 Q-loop/lid; other site 1167634011861 ABC transporter signature motif; other site 1167634011862 Walker B; other site 1167634011863 D-loop; other site 1167634011864 H-loop/switch region; other site 1167634011865 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1167634011866 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1167634011867 active site 1167634011868 catalytic tetrad [active] 1167634011869 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1167634011870 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1167634011871 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1167634011872 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1167634011873 active site 1167634011874 metal binding site [ion binding]; metal-binding site 1167634011875 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1167634011876 Transglycosylase; Region: Transgly; pfam00912 1167634011877 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1167634011878 Cupin domain; Region: Cupin_2; cl17218 1167634011879 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634011880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634011881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634011882 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634011883 putative substrate translocation pore; other site 1167634011884 PgaD-like protein; Region: PgaD; cl14676 1167634011885 N-glycosyltransferase; Provisional; Region: PRK11204 1167634011886 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1167634011887 DXD motif; other site 1167634011888 Immunoglobulin domain; Region: Ig; cl11960 1167634011889 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 1167634011890 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1167634011891 putative active site [active] 1167634011892 putative metal binding site [ion binding]; other site 1167634011893 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 1167634011894 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634011895 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634011896 metal binding site [ion binding]; metal-binding site 1167634011897 active site 1167634011898 I-site; other site 1167634011899 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1167634011900 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1167634011901 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1167634011902 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1167634011903 CoenzymeA binding site [chemical binding]; other site 1167634011904 subunit interaction site [polypeptide binding]; other site 1167634011905 PHB binding site; other site 1167634011906 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1167634011907 active site 1167634011908 DNA polymerase IV; Validated; Region: PRK02406 1167634011909 DNA binding site [nucleotide binding] 1167634011910 Yqey-like protein; Region: YqeY; pfam09424 1167634011911 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1167634011912 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1167634011913 dimer interface [polypeptide binding]; other site 1167634011914 active site 1167634011915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634011916 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1167634011917 NAD(P) binding site [chemical binding]; other site 1167634011918 active site 1167634011919 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1167634011920 putative active site 1 [active] 1167634011921 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1167634011922 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1167634011923 active site 1167634011924 Predicted exporter [General function prediction only]; Region: COG4258 1167634011925 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1167634011926 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1167634011927 putative acyl-acceptor binding pocket; other site 1167634011928 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1167634011929 Putative Catalytic site; other site 1167634011930 DXD motif; other site 1167634011931 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1167634011932 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634011933 acyl-activating enzyme (AAE) consensus motif; other site 1167634011934 AMP binding site [chemical binding]; other site 1167634011935 active site 1167634011936 CoA binding site [chemical binding]; other site 1167634011937 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1167634011938 active site 2 [active] 1167634011939 active site 1 [active] 1167634011940 Predicted membrane protein [Function unknown]; Region: COG4648 1167634011941 acyl carrier protein; Provisional; Region: PRK05350 1167634011942 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1167634011943 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1167634011944 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1167634011945 putative acyl-acceptor binding pocket; other site 1167634011946 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1167634011947 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1167634011948 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1167634011949 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1167634011950 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1167634011951 heme-binding site [chemical binding]; other site 1167634011952 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1167634011953 FAD binding pocket [chemical binding]; other site 1167634011954 FAD binding motif [chemical binding]; other site 1167634011955 phosphate binding motif [ion binding]; other site 1167634011956 beta-alpha-beta structure motif; other site 1167634011957 NAD binding pocket [chemical binding]; other site 1167634011958 Heme binding pocket [chemical binding]; other site 1167634011959 Predicted transcriptional regulator [Transcription]; Region: COG1959 1167634011960 Transcriptional regulator; Region: Rrf2; cl17282 1167634011961 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1167634011962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1167634011963 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634011964 EamA-like transporter family; Region: EamA; pfam00892 1167634011965 EamA-like transporter family; Region: EamA; pfam00892 1167634011966 Proline dehydrogenase; Region: Pro_dh; cl03282 1167634011967 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1167634011968 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634011969 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1167634011970 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1167634011971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634011972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634011973 dimerization interface [polypeptide binding]; other site 1167634011974 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1167634011975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634011976 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634011977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634011978 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634011979 dimerization interface [polypeptide binding]; other site 1167634011980 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1167634011981 putative effector binding pocket; other site 1167634011982 putative dimerization interface [polypeptide binding]; other site 1167634011983 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634011984 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1167634011985 putative C-terminal domain interface [polypeptide binding]; other site 1167634011986 putative GSH binding site (G-site) [chemical binding]; other site 1167634011987 putative dimer interface [polypeptide binding]; other site 1167634011988 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1167634011989 putative N-terminal domain interface [polypeptide binding]; other site 1167634011990 putative dimer interface [polypeptide binding]; other site 1167634011991 putative substrate binding pocket (H-site) [chemical binding]; other site 1167634011992 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1167634011993 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1167634011994 Predicted transcriptional regulators [Transcription]; Region: COG1733 1167634011995 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1167634011996 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1167634011997 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634011998 Walker A/P-loop; other site 1167634011999 ATP binding site [chemical binding]; other site 1167634012000 Q-loop/lid; other site 1167634012001 ABC transporter signature motif; other site 1167634012002 Walker B; other site 1167634012003 D-loop; other site 1167634012004 H-loop/switch region; other site 1167634012005 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634012006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634012007 dimer interface [polypeptide binding]; other site 1167634012008 conserved gate region; other site 1167634012009 putative PBP binding loops; other site 1167634012010 ABC-ATPase subunit interface; other site 1167634012011 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1167634012012 NMT1-like family; Region: NMT1_2; pfam13379 1167634012013 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634012014 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634012015 active site 1167634012016 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1167634012017 acyl-CoA synthetase; Validated; Region: PRK08162 1167634012018 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1167634012019 acyl-activating enzyme (AAE) consensus motif; other site 1167634012020 putative active site [active] 1167634012021 AMP binding site [chemical binding]; other site 1167634012022 putative CoA binding site [chemical binding]; other site 1167634012023 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1167634012024 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1167634012025 ligand binding site [chemical binding]; other site 1167634012026 flexible hinge region; other site 1167634012027 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1167634012028 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1167634012029 aspartate racemase; Region: asp_race; TIGR00035 1167634012030 MarR family; Region: MarR_2; pfam12802 1167634012031 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1167634012032 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1167634012033 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1167634012034 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1167634012035 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1167634012036 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1167634012037 ligand binding site [chemical binding]; other site 1167634012038 flexible hinge region; other site 1167634012039 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1167634012040 putative switch regulator; other site 1167634012041 non-specific DNA interactions [nucleotide binding]; other site 1167634012042 DNA binding site [nucleotide binding] 1167634012043 sequence specific DNA binding site [nucleotide binding]; other site 1167634012044 putative cAMP binding site [chemical binding]; other site 1167634012045 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1167634012046 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1167634012047 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1167634012048 Cytochrome c; Region: Cytochrom_C; cl11414 1167634012049 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1167634012050 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1167634012051 dimer interface [polypeptide binding]; other site 1167634012052 TPP-binding site [chemical binding]; other site 1167634012053 glutathione reductase; Validated; Region: PRK06116 1167634012054 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1167634012055 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634012056 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1167634012057 Protein of unknown function DUF72; Region: DUF72; pfam01904 1167634012058 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634012059 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634012060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634012061 DNA-binding site [nucleotide binding]; DNA binding site 1167634012062 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634012063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634012064 homodimer interface [polypeptide binding]; other site 1167634012065 catalytic residue [active] 1167634012066 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1167634012067 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1167634012068 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634012069 EamA-like transporter family; Region: EamA; pfam00892 1167634012070 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1167634012071 catalytic residues [active] 1167634012072 allantoate amidohydrolase; Reviewed; Region: PRK12890 1167634012073 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1167634012074 active site 1167634012075 metal binding site [ion binding]; metal-binding site 1167634012076 dimer interface [polypeptide binding]; other site 1167634012077 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1167634012078 multidrug efflux protein; Reviewed; Region: PRK01766 1167634012079 cation binding site [ion binding]; other site 1167634012080 enoyl-CoA hydratase; Provisional; Region: PRK05995 1167634012081 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634012082 substrate binding site [chemical binding]; other site 1167634012083 oxyanion hole (OAH) forming residues; other site 1167634012084 trimer interface [polypeptide binding]; other site 1167634012085 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634012086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634012087 NAD(P) binding site [chemical binding]; other site 1167634012088 active site 1167634012089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634012090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634012091 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1167634012092 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1167634012093 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 1167634012094 active site 1167634012095 acyl-activating enzyme (AAE) consensus motif; other site 1167634012096 putative CoA binding site [chemical binding]; other site 1167634012097 AMP binding site [chemical binding]; other site 1167634012098 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1167634012099 active site 1167634012100 substrate-binding site [chemical binding]; other site 1167634012101 metal-binding site [ion binding] 1167634012102 GTP binding site [chemical binding]; other site 1167634012103 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1167634012104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634012105 S-adenosylmethionine binding site [chemical binding]; other site 1167634012106 short chain dehydrogenase; Provisional; Region: PRK08265 1167634012107 classical (c) SDRs; Region: SDR_c; cd05233 1167634012108 NAD(P) binding site [chemical binding]; other site 1167634012109 active site 1167634012110 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1167634012111 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1167634012112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1167634012113 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1167634012114 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1167634012115 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634012116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634012117 Predicted transcriptional regulator [Transcription]; Region: COG2944 1167634012118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634012119 non-specific DNA binding site [nucleotide binding]; other site 1167634012120 salt bridge; other site 1167634012121 sequence-specific DNA binding site [nucleotide binding]; other site 1167634012122 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1167634012123 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1167634012124 putative NAD(P) binding site [chemical binding]; other site 1167634012125 active site 1167634012126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634012127 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1167634012128 ligand binding site [chemical binding]; other site 1167634012129 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1167634012130 NAD binding site [chemical binding]; other site 1167634012131 dimerization interface [polypeptide binding]; other site 1167634012132 catalytic site [active] 1167634012133 hypothetical protein; Validated; Region: PRK06201 1167634012134 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1167634012135 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634012136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012137 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634012138 dimerization interface [polypeptide binding]; other site 1167634012139 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1167634012140 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1167634012141 phosphate binding site [ion binding]; other site 1167634012142 Protein of unknown function (DUF560); Region: DUF560; pfam04575 1167634012143 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 1167634012144 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634012145 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634012146 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1167634012147 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1167634012148 fec operon regulator FecR; Reviewed; Region: PRK09774 1167634012149 FecR protein; Region: FecR; pfam04773 1167634012150 RNA polymerase sigma factor; Provisional; Region: PRK12528 1167634012151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634012152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634012153 DNA binding residues [nucleotide binding] 1167634012154 Protein of unknown function (DUF1629); Region: DUF1629; pfam07791 1167634012155 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1167634012156 Pirin-related protein [General function prediction only]; Region: COG1741 1167634012157 Pirin; Region: Pirin; pfam02678 1167634012158 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1167634012159 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1167634012160 putative active site [active] 1167634012161 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1167634012162 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1167634012163 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1167634012164 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1167634012165 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1167634012166 catalytic residues [active] 1167634012167 central insert; other site 1167634012168 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1167634012169 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1167634012170 Heme exporter protein D (CcmD); Region: CcmD; cl11475 1167634012171 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1167634012172 heme exporter protein CcmB; Region: ccmB; TIGR01190 1167634012173 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1167634012174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634012175 Walker A/P-loop; other site 1167634012176 ATP binding site [chemical binding]; other site 1167634012177 Q-loop/lid; other site 1167634012178 ABC transporter signature motif; other site 1167634012179 Walker B; other site 1167634012180 D-loop; other site 1167634012181 H-loop/switch region; other site 1167634012182 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1167634012183 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1167634012184 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1167634012185 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1167634012186 molybdopterin cofactor binding site [chemical binding]; other site 1167634012187 substrate binding site [chemical binding]; other site 1167634012188 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1167634012189 molybdopterin cofactor binding site; other site 1167634012190 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1167634012191 tetrathionate reductase subunit B; Provisional; Region: PRK14993 1167634012192 4Fe-4S binding domain; Region: Fer4; pfam00037 1167634012193 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1167634012194 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1167634012195 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1167634012196 molybdopterin cofactor binding site; other site 1167634012197 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1167634012198 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1167634012199 putative molybdopterin cofactor binding site; other site 1167634012200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1167634012201 TPR motif; other site 1167634012202 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1167634012203 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1167634012204 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1167634012205 catalytic residues [active] 1167634012206 central insert; other site 1167634012207 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1167634012208 CcmE; Region: CcmE; pfam03100 1167634012209 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1167634012210 CcmB protein; Region: CcmB; cl17444 1167634012211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634012212 Walker A/P-loop; other site 1167634012213 ATP binding site [chemical binding]; other site 1167634012214 Q-loop/lid; other site 1167634012215 ABC transporter signature motif; other site 1167634012216 Walker B; other site 1167634012217 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 1167634012218 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 1167634012219 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 1167634012220 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1167634012221 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1167634012222 [4Fe-4S] binding site [ion binding]; other site 1167634012223 molybdopterin cofactor binding site; other site 1167634012224 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1167634012225 molybdopterin cofactor binding site; other site 1167634012226 NapD protein; Region: NapD; pfam03927 1167634012227 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 1167634012228 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1167634012229 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1167634012230 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634012231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634012232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012233 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1167634012234 putative dimerization interface [polypeptide binding]; other site 1167634012235 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634012236 FCD domain; Region: FCD; pfam07729 1167634012237 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1167634012238 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634012239 RNase II stability modulator; Provisional; Region: PRK10060 1167634012240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634012241 putative active site [active] 1167634012242 heme pocket [chemical binding]; other site 1167634012243 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634012244 metal binding site [ion binding]; metal-binding site 1167634012245 active site 1167634012246 I-site; other site 1167634012247 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634012248 enoyl-CoA hydratase; Validated; Region: PRK08788 1167634012249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634012250 substrate binding site [chemical binding]; other site 1167634012251 oxyanion hole (OAH) forming residues; other site 1167634012252 trimer interface [polypeptide binding]; other site 1167634012253 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634012254 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634012255 N-terminal plug; other site 1167634012256 ligand-binding site [chemical binding]; other site 1167634012257 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1167634012258 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1167634012259 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634012260 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634012261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012262 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1167634012263 putative dimerization interface [polypeptide binding]; other site 1167634012264 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634012265 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634012266 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1167634012267 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634012268 substrate binding site [chemical binding]; other site 1167634012269 oxyanion hole (OAH) forming residues; other site 1167634012270 trimer interface [polypeptide binding]; other site 1167634012271 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1167634012272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634012273 NAD(P) binding site [chemical binding]; other site 1167634012274 active site 1167634012275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634012276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012277 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1167634012278 putative effector binding pocket; other site 1167634012279 putative dimerization interface [polypeptide binding]; other site 1167634012280 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1167634012281 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634012282 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634012283 N-terminal plug; other site 1167634012284 ligand-binding site [chemical binding]; other site 1167634012285 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1167634012286 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634012287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634012288 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1167634012289 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 1167634012290 nudix motif; other site 1167634012291 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1167634012292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634012293 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1167634012294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634012295 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634012296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634012297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634012299 dimerization interface [polypeptide binding]; other site 1167634012300 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1167634012301 active site 1167634012302 intersubunit interface [polypeptide binding]; other site 1167634012303 Zn2+ binding site [ion binding]; other site 1167634012304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634012305 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634012306 putative substrate translocation pore; other site 1167634012307 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1167634012308 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1167634012309 putative catalytic residue [active] 1167634012310 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634012311 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1167634012312 putative ligand binding site [chemical binding]; other site 1167634012313 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1167634012314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634012315 DNA-binding site [nucleotide binding]; DNA binding site 1167634012316 UTRA domain; Region: UTRA; cl17743 1167634012317 acyl-CoA synthetase; Validated; Region: PRK06164 1167634012318 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634012319 acyl-activating enzyme (AAE) consensus motif; other site 1167634012320 AMP binding site [chemical binding]; other site 1167634012321 active site 1167634012322 CoA binding site [chemical binding]; other site 1167634012323 Putative cyclase; Region: Cyclase; pfam04199 1167634012324 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634012325 short chain dehydrogenase; Provisional; Region: PRK07577 1167634012326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634012327 NAD(P) binding site [chemical binding]; other site 1167634012328 active site 1167634012329 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1167634012330 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1167634012331 conserved cys residue [active] 1167634012332 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634012333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634012334 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1167634012335 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1167634012336 conserved cys residue [active] 1167634012337 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634012338 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634012339 putative DNA binding site [nucleotide binding]; other site 1167634012340 putative Zn2+ binding site [ion binding]; other site 1167634012341 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634012342 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634012343 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634012344 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1167634012345 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1167634012346 Walker A/P-loop; other site 1167634012347 ATP binding site [chemical binding]; other site 1167634012348 Q-loop/lid; other site 1167634012349 ABC transporter signature motif; other site 1167634012350 Walker B; other site 1167634012351 D-loop; other site 1167634012352 H-loop/switch region; other site 1167634012353 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1167634012354 DctM-like transporters; Region: DctM; pfam06808 1167634012355 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1167634012356 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1167634012357 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1167634012358 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634012359 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1167634012360 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634012361 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 1167634012362 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1167634012363 active site 1167634012364 acyl-CoA synthetase; Validated; Region: PRK07470 1167634012365 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1167634012366 acyl-activating enzyme (AAE) consensus motif; other site 1167634012367 putative AMP binding site [chemical binding]; other site 1167634012368 putative active site [active] 1167634012369 putative CoA binding site [chemical binding]; other site 1167634012370 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634012371 classical (c) SDRs; Region: SDR_c; cd05233 1167634012372 NAD(P) binding site [chemical binding]; other site 1167634012373 active site 1167634012374 Domain of unknown function (DUF296); Region: DUF296; pfam03479 1167634012375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634012376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012377 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634012378 dimerization interface [polypeptide binding]; other site 1167634012379 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1167634012380 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1167634012381 Penicillin G acylase (PGA) is the key enzyme in the industrial production of beta-lactam antibiotics. PGA hydrolyzes the side chain of penicillin G and related beta-lactam antibiotics releasing 6-amino penicillanic acid (6-APA), a building block in the...; Region: Ntn_PGA; cd03748 1167634012382 active site 1167634012383 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1167634012384 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1167634012385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634012386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634012387 Walker A/P-loop; other site 1167634012388 ATP binding site [chemical binding]; other site 1167634012389 Q-loop/lid; other site 1167634012390 ABC transporter signature motif; other site 1167634012391 Walker B; other site 1167634012392 D-loop; other site 1167634012393 H-loop/switch region; other site 1167634012394 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634012395 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1167634012396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634012397 Walker A/P-loop; other site 1167634012398 ATP binding site [chemical binding]; other site 1167634012399 Q-loop/lid; other site 1167634012400 ABC transporter signature motif; other site 1167634012401 Walker B; other site 1167634012402 D-loop; other site 1167634012403 H-loop/switch region; other site 1167634012404 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1167634012405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634012407 dimerization interface [polypeptide binding]; other site 1167634012408 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1167634012409 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1167634012410 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634012411 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012412 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634012413 dimerization interface [polypeptide binding]; other site 1167634012414 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1167634012415 LysR family transcriptional regulator; Provisional; Region: PRK14997 1167634012416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012417 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634012418 putative effector binding pocket; other site 1167634012419 dimerization interface [polypeptide binding]; other site 1167634012420 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1167634012421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634012422 putative substrate translocation pore; other site 1167634012423 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1167634012424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634012425 putative substrate translocation pore; other site 1167634012426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634012427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634012428 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1167634012429 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 1167634012430 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1167634012431 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1167634012432 DNA binding site [nucleotide binding] 1167634012433 domain linker motif; other site 1167634012434 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 1167634012435 putative dimerization interface [polypeptide binding]; other site 1167634012436 putative ligand binding site [chemical binding]; other site 1167634012437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634012438 D-galactonate transporter; Region: 2A0114; TIGR00893 1167634012439 putative substrate translocation pore; other site 1167634012440 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1167634012441 Amidase; Region: Amidase; cl11426 1167634012442 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1167634012443 inner membrane protein; Provisional; Region: PRK10995 1167634012444 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 1167634012445 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1167634012446 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1167634012447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634012448 S-adenosylmethionine binding site [chemical binding]; other site 1167634012449 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1167634012450 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1167634012451 Nitronate monooxygenase; Region: NMO; pfam03060 1167634012452 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1167634012453 FMN binding site [chemical binding]; other site 1167634012454 substrate binding site [chemical binding]; other site 1167634012455 putative catalytic residue [active] 1167634012456 hypothetical protein; Validated; Region: PRK07080 1167634012457 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1167634012458 active site 1 [active] 1167634012459 active site 2 [active] 1167634012460 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1167634012461 putative catalytic site [active] 1167634012462 putative phosphate binding site [ion binding]; other site 1167634012463 active site 1167634012464 metal binding site A [ion binding]; metal-binding site 1167634012465 DNA binding site [nucleotide binding] 1167634012466 putative AP binding site [nucleotide binding]; other site 1167634012467 putative metal binding site B [ion binding]; other site 1167634012468 Tir chaperone protein (CesT) family; Region: CesT; cl08444 1167634012469 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 1167634012470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634012471 NAD(P) binding site [chemical binding]; other site 1167634012472 active site 1167634012473 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1167634012474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634012475 DNA-binding site [nucleotide binding]; DNA binding site 1167634012476 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1167634012477 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1167634012478 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 1167634012479 NAD(P) binding site [chemical binding]; other site 1167634012480 catalytic residues [active] 1167634012481 catalytic residues [active] 1167634012482 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1167634012483 Lumazine binding domain; Region: Lum_binding; pfam00677 1167634012484 Lumazine binding domain; Region: Lum_binding; pfam00677 1167634012485 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1167634012486 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1167634012487 MlrC C-terminus; Region: MlrC_C; pfam07171 1167634012488 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1167634012489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634012490 putative substrate translocation pore; other site 1167634012491 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634012492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012493 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634012494 dimerization interface [polypeptide binding]; other site 1167634012495 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1167634012496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634012497 Coenzyme A binding pocket [chemical binding]; other site 1167634012498 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1167634012499 Heavy-metal-associated domain; Region: HMA; pfam00403 1167634012500 metal-binding site [ion binding] 1167634012501 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1167634012502 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1167634012503 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1167634012504 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1167634012505 DNA binding residues [nucleotide binding] 1167634012506 dimer interface [polypeptide binding]; other site 1167634012507 putative metal binding site [ion binding]; other site 1167634012508 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1167634012509 putative FMN binding site [chemical binding]; other site 1167634012510 RNA polymerase sigma factor; Provisional; Region: PRK12528 1167634012511 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634012512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634012513 DNA binding residues [nucleotide binding] 1167634012514 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634012515 FecR protein; Region: FecR; pfam04773 1167634012516 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634012517 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1167634012518 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634012519 N-terminal plug; other site 1167634012520 ligand-binding site [chemical binding]; other site 1167634012521 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 1167634012522 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1167634012523 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1167634012524 tetramer interface [polypeptide binding]; other site 1167634012525 TPP-binding site [chemical binding]; other site 1167634012526 heterodimer interface [polypeptide binding]; other site 1167634012527 phosphorylation loop region [posttranslational modification] 1167634012528 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1167634012529 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1167634012530 alpha subunit interface [polypeptide binding]; other site 1167634012531 TPP binding site [chemical binding]; other site 1167634012532 heterodimer interface [polypeptide binding]; other site 1167634012533 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1167634012534 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1167634012535 E3 interaction surface; other site 1167634012536 lipoyl attachment site [posttranslational modification]; other site 1167634012537 e3 binding domain; Region: E3_binding; pfam02817 1167634012538 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1167634012539 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1167634012540 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1167634012541 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634012542 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1167634012543 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1167634012544 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1167634012545 argininosuccinate lyase; Provisional; Region: PRK00855 1167634012546 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1167634012547 active sites [active] 1167634012548 tetramer interface [polypeptide binding]; other site 1167634012549 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1167634012550 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1167634012551 NAD synthetase; Reviewed; Region: nadE; PRK02628 1167634012552 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1167634012553 multimer interface [polypeptide binding]; other site 1167634012554 active site 1167634012555 catalytic triad [active] 1167634012556 protein interface 1 [polypeptide binding]; other site 1167634012557 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1167634012558 homodimer interface [polypeptide binding]; other site 1167634012559 NAD binding pocket [chemical binding]; other site 1167634012560 ATP binding pocket [chemical binding]; other site 1167634012561 Mg binding site [ion binding]; other site 1167634012562 active-site loop [active] 1167634012563 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1167634012564 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1167634012565 type II secretion system protein F; Region: GspF; TIGR02120 1167634012566 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1167634012567 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1167634012568 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1167634012569 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1167634012570 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1167634012571 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1167634012572 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1167634012573 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1167634012574 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1167634012575 Walker A motif; other site 1167634012576 ATP binding site [chemical binding]; other site 1167634012577 Walker B motif; other site 1167634012578 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1167634012579 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1167634012580 catalytic residues [active] 1167634012581 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1167634012582 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634012583 N-terminal plug; other site 1167634012584 ligand-binding site [chemical binding]; other site 1167634012585 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 1167634012586 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 1167634012587 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1167634012588 GspL periplasmic domain; Region: GspL_C; cl14909 1167634012589 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1167634012590 type II secretion system protein J; Region: gspJ; TIGR01711 1167634012591 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1167634012592 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1167634012593 Type II transport protein GspH; Region: GspH; pfam12019 1167634012594 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1167634012595 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1167634012596 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1167634012597 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1167634012598 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1167634012599 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1167634012600 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1167634012601 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1167634012602 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1167634012603 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634012604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012605 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634012606 dimerization interface [polypeptide binding]; other site 1167634012607 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1167634012608 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1167634012609 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 1167634012610 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1167634012611 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634012612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634012613 dimer interface [polypeptide binding]; other site 1167634012614 conserved gate region; other site 1167634012615 putative PBP binding loops; other site 1167634012616 ABC-ATPase subunit interface; other site 1167634012617 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1167634012618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634012619 dimer interface [polypeptide binding]; other site 1167634012620 conserved gate region; other site 1167634012621 putative PBP binding loops; other site 1167634012622 ABC-ATPase subunit interface; other site 1167634012623 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1167634012624 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634012625 Walker A/P-loop; other site 1167634012626 ATP binding site [chemical binding]; other site 1167634012627 Q-loop/lid; other site 1167634012628 ABC transporter signature motif; other site 1167634012629 Walker B; other site 1167634012630 D-loop; other site 1167634012631 H-loop/switch region; other site 1167634012632 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1167634012633 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634012634 Walker A/P-loop; other site 1167634012635 ATP binding site [chemical binding]; other site 1167634012636 Q-loop/lid; other site 1167634012637 ABC transporter signature motif; other site 1167634012638 Walker B; other site 1167634012639 D-loop; other site 1167634012640 H-loop/switch region; other site 1167634012641 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634012642 YaeQ protein; Region: YaeQ; pfam07152 1167634012643 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634012644 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634012645 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1167634012646 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1167634012647 NAD(P) binding site [chemical binding]; other site 1167634012648 substrate binding site [chemical binding]; other site 1167634012649 dimer interface [polypeptide binding]; other site 1167634012650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634012651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634012652 short chain dehydrogenase; Validated; Region: PRK08264 1167634012653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634012654 NAD(P) binding site [chemical binding]; other site 1167634012655 active site 1167634012656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634012657 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1167634012658 putative substrate translocation pore; other site 1167634012659 Chorismate lyase; Region: Chor_lyase; cl01230 1167634012660 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1167634012661 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1167634012662 RNA binding surface [nucleotide binding]; other site 1167634012663 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1167634012664 active site 1167634012665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634012666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012667 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634012668 putative effector binding pocket; other site 1167634012669 dimerization interface [polypeptide binding]; other site 1167634012670 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1167634012671 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634012672 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634012673 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1167634012674 Protein export membrane protein; Region: SecD_SecF; cl14618 1167634012675 Protein export membrane protein; Region: SecD_SecF; cl14618 1167634012676 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1167634012677 Predicted membrane protein [Function unknown]; Region: COG2261 1167634012678 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1167634012679 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1167634012680 Cu(I) binding site [ion binding]; other site 1167634012681 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1167634012682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1167634012683 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1167634012684 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1167634012685 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1167634012686 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1167634012687 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1167634012688 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1167634012689 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1167634012690 active site 1167634012691 Zn binding site [ion binding]; other site 1167634012692 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 1167634012693 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1167634012694 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1167634012695 homodimer interface [polypeptide binding]; other site 1167634012696 NADP binding site [chemical binding]; other site 1167634012697 substrate binding site [chemical binding]; other site 1167634012698 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1167634012699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634012700 active site 1167634012701 phosphorylation site [posttranslational modification] 1167634012702 intermolecular recognition site; other site 1167634012703 dimerization interface [polypeptide binding]; other site 1167634012704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634012705 DNA binding residues [nucleotide binding] 1167634012706 dimerization interface [polypeptide binding]; other site 1167634012707 PAS domain S-box; Region: sensory_box; TIGR00229 1167634012708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634012709 putative active site [active] 1167634012710 heme pocket [chemical binding]; other site 1167634012711 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1167634012712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634012713 dimer interface [polypeptide binding]; other site 1167634012714 phosphorylation site [posttranslational modification] 1167634012715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634012716 ATP binding site [chemical binding]; other site 1167634012717 Mg2+ binding site [ion binding]; other site 1167634012718 G-X-G motif; other site 1167634012719 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1167634012720 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1167634012721 dimer interface [polypeptide binding]; other site 1167634012722 TPP-binding site [chemical binding]; other site 1167634012723 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1167634012724 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1167634012725 E3 interaction surface; other site 1167634012726 lipoyl attachment site [posttranslational modification]; other site 1167634012727 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1167634012728 E3 interaction surface; other site 1167634012729 lipoyl attachment site [posttranslational modification]; other site 1167634012730 e3 binding domain; Region: E3_binding; pfam02817 1167634012731 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1167634012732 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1167634012733 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1167634012734 E3 interaction surface; other site 1167634012735 lipoyl attachment site [posttranslational modification]; other site 1167634012736 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1167634012737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1167634012738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634012739 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1167634012740 short chain dehydrogenase; Provisional; Region: PRK12744 1167634012741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634012742 NAD(P) binding site [chemical binding]; other site 1167634012743 active site 1167634012744 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634012745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634012746 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1167634012747 putative effector binding pocket; other site 1167634012748 putative dimerization interface [polypeptide binding]; other site 1167634012749 Putative motility protein; Region: YjfB_motility; pfam14070 1167634012750 flagellin; Validated; Region: PRK08026 1167634012751 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1167634012752 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1167634012753 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 1167634012754 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1167634012755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634012756 S-adenosylmethionine binding site [chemical binding]; other site 1167634012757 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 1167634012758 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1167634012759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634012760 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1167634012761 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634012762 DNA binding residues [nucleotide binding] 1167634012763 transcriptional activator FlhD; Provisional; Region: PRK02909 1167634012764 transcriptional activator FlhC; Provisional; Region: PRK12722 1167634012765 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1167634012766 flagellar motor protein MotA; Validated; Region: PRK09110 1167634012767 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1167634012768 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1167634012769 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1167634012770 ligand binding site [chemical binding]; other site 1167634012771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634012772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634012773 active site 1167634012774 phosphorylation site [posttranslational modification] 1167634012775 intermolecular recognition site; other site 1167634012776 dimerization interface [polypeptide binding]; other site 1167634012777 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1167634012778 putative binding surface; other site 1167634012779 active site 1167634012780 CheY binding; Region: CheY-binding; pfam09078 1167634012781 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1167634012782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634012783 ATP binding site [chemical binding]; other site 1167634012784 Mg2+ binding site [ion binding]; other site 1167634012785 G-X-G motif; other site 1167634012786 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1167634012787 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1167634012788 putative CheA interaction surface; other site 1167634012789 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1167634012790 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1167634012791 dimer interface [polypeptide binding]; other site 1167634012792 ligand binding site [chemical binding]; other site 1167634012793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634012794 dimerization interface [polypeptide binding]; other site 1167634012795 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634012796 dimer interface [polypeptide binding]; other site 1167634012797 putative CheW interface [polypeptide binding]; other site 1167634012798 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1167634012799 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1167634012800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634012801 S-adenosylmethionine binding site [chemical binding]; other site 1167634012802 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1167634012803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634012804 active site 1167634012805 phosphorylation site [posttranslational modification] 1167634012806 intermolecular recognition site; other site 1167634012807 dimerization interface [polypeptide binding]; other site 1167634012808 CheB methylesterase; Region: CheB_methylest; pfam01339 1167634012809 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1167634012810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634012811 active site 1167634012812 phosphorylation site [posttranslational modification] 1167634012813 intermolecular recognition site; other site 1167634012814 dimerization interface [polypeptide binding]; other site 1167634012815 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1167634012816 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634012817 dimer interface [polypeptide binding]; other site 1167634012818 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1167634012819 putative CheW interface [polypeptide binding]; other site 1167634012820 CHASE3 domain; Region: CHASE3; cl05000 1167634012821 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1167634012822 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1167634012823 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1167634012824 FHIPEP family; Region: FHIPEP; pfam00771 1167634012825 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 1167634012826 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1167634012827 FlgN protein; Region: FlgN; pfam05130 1167634012828 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 1167634012829 SAF-like; Region: SAF_2; pfam13144 1167634012830 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1167634012831 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1167634012832 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1167634012833 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1167634012834 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1167634012835 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1167634012836 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1167634012837 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK12633 1167634012838 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1167634012839 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1167634012840 flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637 1167634012841 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1167634012842 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1167634012843 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1167634012844 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1167634012845 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1167634012846 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 1167634012847 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1167634012848 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1167634012849 Flagellar L-ring protein; Region: FlgH; cl17277 1167634012850 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1167634012851 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1167634012852 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1167634012853 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12713 1167634012854 Rod binding protein; Region: Rod-binding; cl01626 1167634012855 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1167634012856 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1167634012857 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1167634012858 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 1167634012859 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1167634012860 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1167634012861 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1167634012862 dimer interface [polypeptide binding]; other site 1167634012863 ligand binding site [chemical binding]; other site 1167634012864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634012865 dimerization interface [polypeptide binding]; other site 1167634012866 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634012867 dimer interface [polypeptide binding]; other site 1167634012868 putative CheW interface [polypeptide binding]; other site 1167634012869 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1167634012870 ligand binding site [chemical binding]; other site 1167634012871 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634012872 dimerization interface [polypeptide binding]; other site 1167634012873 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1167634012874 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634012875 dimer interface [polypeptide binding]; other site 1167634012876 putative CheW interface [polypeptide binding]; other site 1167634012877 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1167634012878 dimer interface [polypeptide binding]; other site 1167634012879 ligand binding site [chemical binding]; other site 1167634012880 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634012881 dimerization interface [polypeptide binding]; other site 1167634012882 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1167634012883 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634012884 dimer interface [polypeptide binding]; other site 1167634012885 putative CheW interface [polypeptide binding]; other site 1167634012886 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634012887 PAS fold; Region: PAS_3; pfam08447 1167634012888 putative active site [active] 1167634012889 heme pocket [chemical binding]; other site 1167634012890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634012891 dimerization interface [polypeptide binding]; other site 1167634012892 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1167634012893 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634012894 dimer interface [polypeptide binding]; other site 1167634012895 putative CheW interface [polypeptide binding]; other site 1167634012896 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1167634012897 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1167634012898 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1167634012899 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1167634012900 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1167634012901 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1167634012902 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1167634012903 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1167634012904 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1167634012905 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1167634012906 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1167634012907 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1167634012908 Walker A motif/ATP binding site; other site 1167634012909 Walker B motif; other site 1167634012910 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 1167634012911 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1167634012912 Flagellar assembly protein FliH; Region: FliH; pfam02108 1167634012913 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1167634012914 FliG C-terminal domain; Region: FliG_C; pfam01706 1167634012915 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1167634012916 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1167634012917 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1167634012918 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1167634012919 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1167634012920 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1167634012921 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1167634012922 Flagellar protein FliT; Region: FliT; pfam05400 1167634012923 Flagellar protein FliS; Region: FliS; cl00654 1167634012924 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1167634012925 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1167634012926 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1167634012927 FlaG protein; Region: FlaG; pfam03646 1167634012928 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1167634012929 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634012930 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634012931 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634012932 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634012933 active site 1167634012934 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634012935 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634012936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634012937 Cupin domain; Region: Cupin_2; pfam07883 1167634012938 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1167634012939 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1167634012940 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1167634012941 Sporulation related domain; Region: SPOR; pfam05036 1167634012942 Colicin V production protein; Region: Colicin_V; pfam02674 1167634012943 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1167634012944 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1167634012945 active site 1167634012946 tetramer interface [polypeptide binding]; other site 1167634012947 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1167634012948 active site 1167634012949 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1167634012950 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1167634012951 MarC family integral membrane protein; Region: MarC; cl00919 1167634012952 PII uridylyl-transferase; Provisional; Region: PRK03059 1167634012953 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1167634012954 metal binding triad; other site 1167634012955 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1167634012956 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1167634012957 Zn2+ binding site [ion binding]; other site 1167634012958 Mg2+ binding site [ion binding]; other site 1167634012959 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1167634012960 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1167634012961 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1167634012962 active site 1167634012963 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1167634012964 rRNA interaction site [nucleotide binding]; other site 1167634012965 S8 interaction site; other site 1167634012966 putative laminin-1 binding site; other site 1167634012967 elongation factor Ts; Provisional; Region: tsf; PRK09377 1167634012968 UBA/TS-N domain; Region: UBA; pfam00627 1167634012969 Elongation factor TS; Region: EF_TS; pfam00889 1167634012970 Elongation factor TS; Region: EF_TS; pfam00889 1167634012971 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1167634012972 putative nucleotide binding site [chemical binding]; other site 1167634012973 uridine monophosphate binding site [chemical binding]; other site 1167634012974 homohexameric interface [polypeptide binding]; other site 1167634012975 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1167634012976 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1167634012977 hinge region; other site 1167634012978 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 1167634012979 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1167634012980 catalytic residue [active] 1167634012981 putative FPP diphosphate binding site; other site 1167634012982 putative FPP binding hydrophobic cleft; other site 1167634012983 dimer interface [polypeptide binding]; other site 1167634012984 putative IPP diphosphate binding site; other site 1167634012985 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1167634012986 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1167634012987 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1167634012988 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1167634012989 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1167634012990 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1167634012991 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1167634012992 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1167634012993 active site 1167634012994 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1167634012995 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1167634012996 protein binding site [polypeptide binding]; other site 1167634012997 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1167634012998 putative substrate binding region [chemical binding]; other site 1167634012999 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1167634013000 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1167634013001 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1167634013002 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1167634013003 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1167634013004 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1167634013005 Surface antigen; Region: Bac_surface_Ag; pfam01103 1167634013006 periplasmic chaperone; Provisional; Region: PRK10780 1167634013007 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1167634013008 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1167634013009 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1167634013010 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1167634013011 trimer interface [polypeptide binding]; other site 1167634013012 active site 1167634013013 UDP-GlcNAc binding site [chemical binding]; other site 1167634013014 lipid binding site [chemical binding]; lipid-binding site 1167634013015 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1167634013016 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1167634013017 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1167634013018 active site 1167634013019 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1167634013020 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1167634013021 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1167634013022 RNA/DNA hybrid binding site [nucleotide binding]; other site 1167634013023 active site 1167634013024 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1167634013025 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1167634013026 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1167634013027 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1167634013028 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1167634013029 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1167634013030 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1167634013031 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634013032 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1167634013033 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634013034 N-terminal plug; other site 1167634013035 ligand-binding site [chemical binding]; other site 1167634013036 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634013037 FecR protein; Region: FecR; pfam04773 1167634013038 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1167634013039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634013040 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634013041 DNA binding residues [nucleotide binding] 1167634013042 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634013043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634013044 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1167634013045 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1167634013046 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1167634013047 DNA binding site [nucleotide binding] 1167634013048 active site 1167634013049 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1167634013050 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1167634013051 catalytic triad [active] 1167634013052 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1167634013053 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1167634013054 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634013055 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634013056 metal binding site [ion binding]; metal-binding site 1167634013057 active site 1167634013058 I-site; other site 1167634013059 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1167634013060 SmpB-tmRNA interface; other site 1167634013061 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1167634013062 putative coenzyme Q binding site [chemical binding]; other site 1167634013063 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 1167634013064 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634013065 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634013066 active site 1167634013067 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1167634013068 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634013069 substrate binding site [chemical binding]; other site 1167634013070 oxyanion hole (OAH) forming residues; other site 1167634013071 trimer interface [polypeptide binding]; other site 1167634013072 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1167634013073 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1167634013074 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1167634013075 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1167634013076 CoenzymeA binding site [chemical binding]; other site 1167634013077 subunit interaction site [polypeptide binding]; other site 1167634013078 PHB binding site; other site 1167634013079 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1167634013080 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1167634013081 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1167634013082 YceG-like family; Region: YceG; pfam02618 1167634013083 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1167634013084 dimerization interface [polypeptide binding]; other site 1167634013085 thymidylate kinase; Region: DTMP_kinase; TIGR00041 1167634013086 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1167634013087 TMP-binding site; other site 1167634013088 ATP-binding site [chemical binding]; other site 1167634013089 DNA polymerase III subunit delta'; Validated; Region: PRK06964 1167634013090 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1167634013091 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1167634013092 active site 1167634013093 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1167634013094 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1167634013095 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1167634013096 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634013097 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634013098 putative DNA binding site [nucleotide binding]; other site 1167634013099 putative Zn2+ binding site [ion binding]; other site 1167634013100 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634013101 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634013102 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634013103 substrate binding pocket [chemical binding]; other site 1167634013104 membrane-bound complex binding site; other site 1167634013105 hinge residues; other site 1167634013106 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1167634013107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634013108 dimer interface [polypeptide binding]; other site 1167634013109 conserved gate region; other site 1167634013110 putative PBP binding loops; other site 1167634013111 ABC-ATPase subunit interface; other site 1167634013112 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634013113 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634013114 Walker A/P-loop; other site 1167634013115 ATP binding site [chemical binding]; other site 1167634013116 Q-loop/lid; other site 1167634013117 ABC transporter signature motif; other site 1167634013118 Walker B; other site 1167634013119 D-loop; other site 1167634013120 H-loop/switch region; other site 1167634013121 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1167634013122 putative active site [active] 1167634013123 putative metal binding site [ion binding]; other site 1167634013124 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1167634013125 FAD binding domain; Region: FAD_binding_4; pfam01565 1167634013126 Berberine and berberine like; Region: BBE; pfam08031 1167634013127 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1167634013128 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1167634013129 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1167634013130 NAD(P) binding site [chemical binding]; other site 1167634013131 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1167634013132 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1167634013133 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1167634013134 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1167634013135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634013136 Coenzyme A binding pocket [chemical binding]; other site 1167634013137 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1167634013138 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1167634013139 C-terminal domain interface [polypeptide binding]; other site 1167634013140 GSH binding site (G-site) [chemical binding]; other site 1167634013141 dimer interface [polypeptide binding]; other site 1167634013142 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1167634013143 N-terminal domain interface [polypeptide binding]; other site 1167634013144 putative dimer interface [polypeptide binding]; other site 1167634013145 active site 1167634013146 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1167634013147 EamA-like transporter family; Region: EamA; pfam00892 1167634013148 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1167634013149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634013150 putative DNA binding site [nucleotide binding]; other site 1167634013151 putative Zn2+ binding site [ion binding]; other site 1167634013152 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634013153 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1167634013154 catalytic residues [active] 1167634013155 dimer interface [polypeptide binding]; other site 1167634013156 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1167634013157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634013158 putative substrate translocation pore; other site 1167634013159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1167634013160 TPR repeat; Region: TPR_11; pfam13414 1167634013161 binding surface 1167634013162 TPR motif; other site 1167634013163 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634013164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634013165 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634013166 dimerization interface [polypeptide binding]; other site 1167634013167 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 1167634013168 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1167634013169 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1167634013170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634013171 PAS domain; Region: PAS_9; pfam13426 1167634013172 putative active site [active] 1167634013173 heme pocket [chemical binding]; other site 1167634013174 HAMP domain; Region: HAMP; pfam00672 1167634013175 dimerization interface [polypeptide binding]; other site 1167634013176 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1167634013177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634013178 dimer interface [polypeptide binding]; other site 1167634013179 putative CheW interface [polypeptide binding]; other site 1167634013180 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1167634013181 DNA photolyase; Region: DNA_photolyase; pfam00875 1167634013182 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634013183 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634013184 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1167634013185 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1167634013186 catalytic triad [active] 1167634013187 Predicted membrane protein [Function unknown]; Region: COG2259 1167634013188 hypothetical protein; Provisional; Region: PRK09256 1167634013189 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1167634013190 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634013191 dimerization interface [polypeptide binding]; other site 1167634013192 putative DNA binding site [nucleotide binding]; other site 1167634013193 putative Zn2+ binding site [ion binding]; other site 1167634013194 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1167634013195 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1167634013196 FMN binding site [chemical binding]; other site 1167634013197 active site 1167634013198 substrate binding site [chemical binding]; other site 1167634013199 catalytic residue [active] 1167634013200 CAAX protease self-immunity; Region: Abi; pfam02517 1167634013201 MAPEG family; Region: MAPEG; cl09190 1167634013202 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1167634013203 NRDE protein; Region: NRDE; cl01315 1167634013204 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1167634013205 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1167634013206 putative deacylase active site [active] 1167634013207 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634013208 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1167634013209 DNA binding site [nucleotide binding] 1167634013210 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1167634013211 Tubulin binding cofactor A; Region: TBCA; pfam02970 1167634013212 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1167634013213 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1167634013214 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1167634013215 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1167634013216 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1167634013217 Walker A/P-loop; other site 1167634013218 ATP binding site [chemical binding]; other site 1167634013219 Q-loop/lid; other site 1167634013220 ABC transporter signature motif; other site 1167634013221 Walker B; other site 1167634013222 D-loop; other site 1167634013223 H-loop/switch region; other site 1167634013224 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634013225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634013226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634013227 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1167634013228 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1167634013229 NAD(P) binding site [chemical binding]; other site 1167634013230 substrate binding site [chemical binding]; other site 1167634013231 dimer interface [polypeptide binding]; other site 1167634013232 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1167634013233 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1167634013234 potential catalytic triad [active] 1167634013235 conserved cys residue [active] 1167634013236 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1167634013237 Zn2+ binding site [ion binding]; other site 1167634013238 Mg2+ binding site [ion binding]; other site 1167634013239 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1167634013240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1167634013241 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1167634013242 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1167634013243 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1167634013244 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1167634013245 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1167634013246 Walker A/P-loop; other site 1167634013247 ATP binding site [chemical binding]; other site 1167634013248 Q-loop/lid; other site 1167634013249 ABC transporter signature motif; other site 1167634013250 Walker B; other site 1167634013251 D-loop; other site 1167634013252 H-loop/switch region; other site 1167634013253 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1167634013254 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1167634013255 Walker A/P-loop; other site 1167634013256 ATP binding site [chemical binding]; other site 1167634013257 Q-loop/lid; other site 1167634013258 ABC transporter signature motif; other site 1167634013259 Walker B; other site 1167634013260 D-loop; other site 1167634013261 H-loop/switch region; other site 1167634013262 TOBE domain; Region: TOBE_2; pfam08402 1167634013263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634013264 dimer interface [polypeptide binding]; other site 1167634013265 putative PBP binding loops; other site 1167634013266 ABC-ATPase subunit interface; other site 1167634013267 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1167634013268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634013269 dimer interface [polypeptide binding]; other site 1167634013270 conserved gate region; other site 1167634013271 putative PBP binding loops; other site 1167634013272 ABC-ATPase subunit interface; other site 1167634013273 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 1167634013274 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1167634013275 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1167634013276 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634013277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634013278 DNA binding site [nucleotide binding] 1167634013279 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1167634013280 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1167634013281 trimer interface [polypeptide binding]; other site 1167634013282 active site 1167634013283 substrate binding site [chemical binding]; other site 1167634013284 CoA binding site [chemical binding]; other site 1167634013285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634013286 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634013287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634013288 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634013289 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1167634013290 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1167634013291 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1167634013292 trimer interface [polypeptide binding]; other site 1167634013293 eyelet of channel; other site 1167634013294 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1167634013295 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1167634013296 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1167634013297 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1167634013298 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1167634013299 Predicted transcriptional regulator [Transcription]; Region: COG1959 1167634013300 Transcriptional regulator; Region: Rrf2; pfam02082 1167634013301 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634013302 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1167634013303 FAD binding site [chemical binding]; other site 1167634013304 homotetramer interface [polypeptide binding]; other site 1167634013305 substrate binding pocket [chemical binding]; other site 1167634013306 catalytic base [active] 1167634013307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1167634013308 TPR motif; other site 1167634013309 binding surface 1167634013310 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1167634013311 Restriction endonuclease; Region: Mrr_cat; pfam04471 1167634013312 S4 domain; Region: S4_2; pfam13275 1167634013313 Protein of unknown function (DUF502); Region: DUF502; pfam04367 1167634013314 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1167634013315 putative DNA binding site [nucleotide binding]; other site 1167634013316 putative Zn2+ binding site [ion binding]; other site 1167634013317 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634013318 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1167634013319 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1167634013320 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1167634013321 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1167634013322 active site 1167634013323 metal binding site [ion binding]; metal-binding site 1167634013324 DNA binding site [nucleotide binding] 1167634013325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634013326 AAA domain; Region: AAA_23; pfam13476 1167634013327 Walker A/P-loop; other site 1167634013328 ATP binding site [chemical binding]; other site 1167634013329 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1167634013330 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634013331 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1167634013332 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1167634013333 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1167634013334 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1167634013335 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1167634013336 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1167634013337 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1167634013338 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1167634013339 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1167634013340 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 1167634013341 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1167634013342 nucleoside/Zn binding site; other site 1167634013343 dimer interface [polypeptide binding]; other site 1167634013344 catalytic motif [active] 1167634013345 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1167634013346 dimer interface [polypeptide binding]; other site 1167634013347 catalytic triad [active] 1167634013348 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1167634013349 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634013350 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634013351 ABC transporter; Region: ABC_tran_2; pfam12848 1167634013352 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634013353 major facilitator superfamily transporter; Provisional; Region: PRK05122 1167634013354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634013355 putative substrate translocation pore; other site 1167634013356 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1167634013357 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634013358 Walker A/P-loop; other site 1167634013359 ATP binding site [chemical binding]; other site 1167634013360 Q-loop/lid; other site 1167634013361 ABC transporter signature motif; other site 1167634013362 Walker B; other site 1167634013363 D-loop; other site 1167634013364 H-loop/switch region; other site 1167634013365 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1167634013366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1167634013367 substrate binding pocket [chemical binding]; other site 1167634013368 membrane-bound complex binding site; other site 1167634013369 hinge residues; other site 1167634013370 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634013371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634013372 dimer interface [polypeptide binding]; other site 1167634013373 conserved gate region; other site 1167634013374 putative PBP binding loops; other site 1167634013375 ABC-ATPase subunit interface; other site 1167634013376 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1167634013377 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634013378 substrate binding pocket [chemical binding]; other site 1167634013379 membrane-bound complex binding site; other site 1167634013380 hinge residues; other site 1167634013381 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1167634013382 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1167634013383 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1167634013384 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1167634013385 catalytic residues [active] 1167634013386 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1167634013387 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1167634013388 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1167634013389 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634013390 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1167634013391 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1167634013392 UGMP family protein; Validated; Region: PRK09604 1167634013393 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1167634013394 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1167634013395 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1167634013396 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1167634013397 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1167634013398 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1167634013399 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1167634013400 Peptidase family M23; Region: Peptidase_M23; pfam01551 1167634013401 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 1167634013402 active site 1167634013403 catalytic site [active] 1167634013404 substrate binding site [chemical binding]; other site 1167634013405 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 1167634013406 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1167634013407 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1167634013408 TRAM domain; Region: TRAM; cl01282 1167634013409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634013410 S-adenosylmethionine binding site [chemical binding]; other site 1167634013411 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1167634013412 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1167634013413 DNA binding residues [nucleotide binding] 1167634013414 dimer interface [polypeptide binding]; other site 1167634013415 copper binding site [ion binding]; other site 1167634013416 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1167634013417 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1167634013418 metal-binding site [ion binding] 1167634013419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1167634013420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1167634013421 motif II; other site 1167634013422 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1167634013423 metal-binding site [ion binding] 1167634013424 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1167634013425 catalytic triad [active] 1167634013426 dimer interface [polypeptide binding]; other site 1167634013427 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1167634013428 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1167634013429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1167634013430 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1167634013431 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1167634013432 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1167634013433 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1167634013434 putative active site [active] 1167634013435 catalytic site [active] 1167634013436 putative metal binding site [ion binding]; other site 1167634013437 glutamate carboxypeptidase; Reviewed; Region: PRK06133 1167634013438 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1167634013439 metal binding site [ion binding]; metal-binding site 1167634013440 dimer interface [polypeptide binding]; other site 1167634013441 SurA N-terminal domain; Region: SurA_N_3; pfam13624 1167634013442 periplasmic folding chaperone; Provisional; Region: PRK10788 1167634013443 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1167634013444 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1167634013445 active site 1167634013446 catalytic triad [active] 1167634013447 oxyanion hole [active] 1167634013448 switch loop; other site 1167634013449 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1167634013450 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1167634013451 Walker A/P-loop; other site 1167634013452 ATP binding site [chemical binding]; other site 1167634013453 Q-loop/lid; other site 1167634013454 ABC transporter signature motif; other site 1167634013455 Walker B; other site 1167634013456 D-loop; other site 1167634013457 H-loop/switch region; other site 1167634013458 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1167634013459 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1167634013460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1167634013461 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1167634013462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634013463 dimer interface [polypeptide binding]; other site 1167634013464 conserved gate region; other site 1167634013465 putative PBP binding loops; other site 1167634013466 ABC-ATPase subunit interface; other site 1167634013467 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1167634013468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634013469 Walker A/P-loop; other site 1167634013470 ATP binding site [chemical binding]; other site 1167634013471 Q-loop/lid; other site 1167634013472 ABC transporter signature motif; other site 1167634013473 Walker B; other site 1167634013474 D-loop; other site 1167634013475 H-loop/switch region; other site 1167634013476 TOBE domain; Region: TOBE_2; pfam08402 1167634013477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634013478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634013479 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1167634013480 dimerization interface [polypeptide binding]; other site 1167634013481 substrate binding pocket [chemical binding]; other site 1167634013482 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1167634013483 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1167634013484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634013485 motif II; other site 1167634013486 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1167634013487 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1167634013488 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1167634013489 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1167634013490 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634013491 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634013492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634013493 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634013494 dimerization interface [polypeptide binding]; other site 1167634013495 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1167634013496 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1167634013497 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1167634013498 DctM-like transporters; Region: DctM; pfam06808 1167634013499 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 1167634013500 amidase; Provisional; Region: PRK07056 1167634013501 Amidase; Region: Amidase; cl11426 1167634013502 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1167634013503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634013504 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634013505 dimerization interface [polypeptide binding]; other site 1167634013506 hypothetical protein; Provisional; Region: PRK05463 1167634013507 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1167634013508 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 1167634013509 putative ligand binding site [chemical binding]; other site 1167634013510 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634013511 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634013512 TM-ABC transporter signature motif; other site 1167634013513 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634013514 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634013515 TM-ABC transporter signature motif; other site 1167634013516 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634013517 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634013518 Walker A/P-loop; other site 1167634013519 ATP binding site [chemical binding]; other site 1167634013520 Q-loop/lid; other site 1167634013521 ABC transporter signature motif; other site 1167634013522 Walker B; other site 1167634013523 D-loop; other site 1167634013524 H-loop/switch region; other site 1167634013525 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634013526 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634013527 Walker A/P-loop; other site 1167634013528 ATP binding site [chemical binding]; other site 1167634013529 Q-loop/lid; other site 1167634013530 ABC transporter signature motif; other site 1167634013531 Walker B; other site 1167634013532 D-loop; other site 1167634013533 H-loop/switch region; other site 1167634013534 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1167634013535 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1167634013536 trimer interface [polypeptide binding]; other site 1167634013537 eyelet of channel; other site 1167634013538 DctM-like transporters; Region: DctM; pfam06808 1167634013539 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1167634013540 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1167634013541 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1167634013542 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1167634013543 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1167634013544 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1167634013545 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1167634013546 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1167634013547 putative NADH binding site [chemical binding]; other site 1167634013548 putative active site [active] 1167634013549 nudix motif; other site 1167634013550 putative metal binding site [ion binding]; other site 1167634013551 MarR family; Region: MarR_2; cl17246 1167634013552 5-oxoprolinase; Region: PLN02666 1167634013553 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1167634013554 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1167634013555 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1167634013556 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1167634013557 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1167634013558 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634013559 substrate binding pocket [chemical binding]; other site 1167634013560 membrane-bound complex binding site; other site 1167634013561 hinge residues; other site 1167634013562 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1167634013563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634013564 dimer interface [polypeptide binding]; other site 1167634013565 conserved gate region; other site 1167634013566 putative PBP binding loops; other site 1167634013567 ABC-ATPase subunit interface; other site 1167634013568 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1167634013569 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634013570 Walker A/P-loop; other site 1167634013571 ATP binding site [chemical binding]; other site 1167634013572 Q-loop/lid; other site 1167634013573 ABC transporter signature motif; other site 1167634013574 Walker B; other site 1167634013575 D-loop; other site 1167634013576 H-loop/switch region; other site 1167634013577 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1167634013578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1167634013579 Zn2+ binding site [ion binding]; other site 1167634013580 Mg2+ binding site [ion binding]; other site 1167634013581 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1167634013582 synthetase active site [active] 1167634013583 NTP binding site [chemical binding]; other site 1167634013584 metal binding site [ion binding]; metal-binding site 1167634013585 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1167634013586 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1167634013587 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1167634013588 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1167634013589 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1167634013590 catalytic site [active] 1167634013591 G-X2-G-X-G-K; other site 1167634013592 Cytochrome c [Energy production and conversion]; Region: COG3258 1167634013593 Cytochrome c; Region: Cytochrom_C; pfam00034 1167634013594 Cytochrome c; Region: Cytochrom_C; cl11414 1167634013595 Cytochrome c; Region: Cytochrom_C; cl11414 1167634013596 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1167634013597 classical (c) SDRs; Region: SDR_c; cd05233 1167634013598 NAD(P) binding site [chemical binding]; other site 1167634013599 active site 1167634013600 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1167634013601 NlpC/P60 family; Region: NLPC_P60; pfam00877 1167634013602 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1167634013603 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634013604 N-terminal plug; other site 1167634013605 ligand-binding site [chemical binding]; other site 1167634013606 AMP nucleosidase; Provisional; Region: PRK08292 1167634013607 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1167634013608 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1167634013609 lysine transporter; Provisional; Region: PRK10836 1167634013610 hypothetical protein; Provisional; Region: PRK11820 1167634013611 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1167634013612 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1167634013613 ribonuclease PH; Reviewed; Region: rph; PRK00173 1167634013614 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1167634013615 hexamer interface [polypeptide binding]; other site 1167634013616 active site 1167634013617 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1167634013618 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634013619 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634013620 active site 1167634013621 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634013622 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1167634013623 FOG: CBS domain [General function prediction only]; Region: COG0517 1167634013624 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634013625 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634013626 metal binding site [ion binding]; metal-binding site 1167634013627 active site 1167634013628 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1167634013629 active site 1167634013630 dimerization interface [polypeptide binding]; other site 1167634013631 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 1167634013632 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1167634013633 FeS/SAM binding site; other site 1167634013634 HemN C-terminal domain; Region: HemN_C; pfam06969 1167634013635 glutamine synthetase; Provisional; Region: glnA; PRK09469 1167634013636 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1167634013637 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1167634013638 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1167634013639 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634013640 putative active site [active] 1167634013641 heme pocket [chemical binding]; other site 1167634013642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634013643 dimer interface [polypeptide binding]; other site 1167634013644 phosphorylation site [posttranslational modification] 1167634013645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634013646 ATP binding site [chemical binding]; other site 1167634013647 Mg2+ binding site [ion binding]; other site 1167634013648 G-X-G motif; other site 1167634013649 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1167634013650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634013651 active site 1167634013652 phosphorylation site [posttranslational modification] 1167634013653 intermolecular recognition site; other site 1167634013654 dimerization interface [polypeptide binding]; other site 1167634013655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634013656 Walker A motif; other site 1167634013657 ATP binding site [chemical binding]; other site 1167634013658 Walker B motif; other site 1167634013659 arginine finger; other site 1167634013660 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1167634013661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634013662 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1167634013663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634013664 dimerization interface [polypeptide binding]; other site 1167634013665 Pirin-related protein [General function prediction only]; Region: COG1741 1167634013666 Pirin; Region: Pirin; pfam02678 1167634013667 Pirin-related protein [General function prediction only]; Region: COG1741 1167634013668 Pirin; Region: Pirin; pfam02678 1167634013669 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1167634013670 RF-1 domain; Region: RF-1; cl17422 1167634013671 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1167634013672 hypothetical protein; Reviewed; Region: PRK09588 1167634013673 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 1167634013674 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634013675 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1167634013676 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1167634013677 Walker A/P-loop; other site 1167634013678 ATP binding site [chemical binding]; other site 1167634013679 Q-loop/lid; other site 1167634013680 ABC transporter signature motif; other site 1167634013681 Walker B; other site 1167634013682 D-loop; other site 1167634013683 H-loop/switch region; other site 1167634013684 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1167634013685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634013686 dimer interface [polypeptide binding]; other site 1167634013687 conserved gate region; other site 1167634013688 putative PBP binding loops; other site 1167634013689 ABC-ATPase subunit interface; other site 1167634013690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634013691 dimer interface [polypeptide binding]; other site 1167634013692 conserved gate region; other site 1167634013693 putative PBP binding loops; other site 1167634013694 ABC-ATPase subunit interface; other site 1167634013695 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1167634013696 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1167634013697 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1167634013698 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1167634013699 FAD binding pocket [chemical binding]; other site 1167634013700 FAD binding motif [chemical binding]; other site 1167634013701 phosphate binding motif [ion binding]; other site 1167634013702 beta-alpha-beta structure motif; other site 1167634013703 NAD binding pocket [chemical binding]; other site 1167634013704 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634013705 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1167634013706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634013707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634013708 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1167634013709 putative dimerization interface [polypeptide binding]; other site 1167634013710 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1167634013711 homotrimer interaction site [polypeptide binding]; other site 1167634013712 putative active site [active] 1167634013713 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1167634013714 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1167634013715 generic binding surface II; other site 1167634013716 ssDNA binding site; other site 1167634013717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1167634013718 ATP binding site [chemical binding]; other site 1167634013719 putative Mg++ binding site [ion binding]; other site 1167634013720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634013721 nucleotide binding region [chemical binding]; other site 1167634013722 ATP-binding site [chemical binding]; other site 1167634013723 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1167634013724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634013725 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1167634013726 dimerization interface [polypeptide binding]; other site 1167634013727 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1167634013728 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1167634013729 dimerization interface [polypeptide binding]; other site 1167634013730 DPS ferroxidase diiron center [ion binding]; other site 1167634013731 ion pore; other site 1167634013732 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1167634013733 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1167634013734 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1167634013735 Vi polysaccharide biosynthesis protein TviD; Provisional; Region: PRK15180 1167634013736 Vi polysaccharide biosynthesis protein TviD; Provisional; Region: PRK15180 1167634013737 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15179 1167634013738 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1167634013739 Vi polysaccharide export protein VexA; Provisional; Region: PRK15175 1167634013740 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1167634013741 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1167634013742 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1167634013743 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1167634013744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634013745 Q-loop/lid; other site 1167634013746 ABC transporter signature motif; other site 1167634013747 Walker B; other site 1167634013748 D-loop; other site 1167634013749 H-loop/switch region; other site 1167634013750 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 1167634013751 Vi polysaccharide export protein VexE; Provisional; Region: PRK15174 1167634013752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1167634013753 TPR motif; other site 1167634013754 binding surface 1167634013755 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1167634013756 putative acyl-acceptor binding pocket; other site 1167634013757 Amb_all domain; Region: Amb_all; smart00656 1167634013758 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1167634013759 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1167634013760 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1167634013761 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1167634013762 dimerization interface [polypeptide binding]; other site 1167634013763 ligand binding site [chemical binding]; other site 1167634013764 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1167634013765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634013766 active site 1167634013767 phosphorylation site [posttranslational modification] 1167634013768 intermolecular recognition site; other site 1167634013769 dimerization interface [polypeptide binding]; other site 1167634013770 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634013771 DNA binding site [nucleotide binding] 1167634013772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634013773 dimerization interface [polypeptide binding]; other site 1167634013774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634013775 dimer interface [polypeptide binding]; other site 1167634013776 phosphorylation site [posttranslational modification] 1167634013777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634013778 ATP binding site [chemical binding]; other site 1167634013779 Mg2+ binding site [ion binding]; other site 1167634013780 G-X-G motif; other site 1167634013781 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1167634013782 Beta-lactamase; Region: Beta-lactamase; pfam00144 1167634013783 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1167634013784 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1167634013785 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1167634013786 Walker A/P-loop; other site 1167634013787 ATP binding site [chemical binding]; other site 1167634013788 Q-loop/lid; other site 1167634013789 ABC transporter signature motif; other site 1167634013790 Walker B; other site 1167634013791 D-loop; other site 1167634013792 H-loop/switch region; other site 1167634013793 TOBE domain; Region: TOBE_2; pfam08402 1167634013794 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1167634013795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634013796 dimer interface [polypeptide binding]; other site 1167634013797 conserved gate region; other site 1167634013798 putative PBP binding loops; other site 1167634013799 ABC-ATPase subunit interface; other site 1167634013800 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1167634013801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634013802 dimer interface [polypeptide binding]; other site 1167634013803 conserved gate region; other site 1167634013804 ABC-ATPase subunit interface; other site 1167634013805 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1167634013806 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1167634013807 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1167634013808 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1167634013809 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1167634013810 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1167634013811 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1167634013812 dimerization interface [polypeptide binding]; other site 1167634013813 ligand binding site [chemical binding]; other site 1167634013814 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634013815 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634013816 TM-ABC transporter signature motif; other site 1167634013817 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1167634013818 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1167634013819 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634013820 TM-ABC transporter signature motif; other site 1167634013821 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1167634013822 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634013823 Walker A/P-loop; other site 1167634013824 ATP binding site [chemical binding]; other site 1167634013825 Q-loop/lid; other site 1167634013826 ABC transporter signature motif; other site 1167634013827 Walker B; other site 1167634013828 D-loop; other site 1167634013829 H-loop/switch region; other site 1167634013830 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634013831 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634013832 Walker A/P-loop; other site 1167634013833 ATP binding site [chemical binding]; other site 1167634013834 Q-loop/lid; other site 1167634013835 ABC transporter signature motif; other site 1167634013836 Walker B; other site 1167634013837 D-loop; other site 1167634013838 H-loop/switch region; other site 1167634013839 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1167634013840 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1167634013841 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1167634013842 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1167634013843 active site 1167634013844 putative substrate binding pocket [chemical binding]; other site 1167634013845 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634013846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634013847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634013848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634013849 dimerization interface [polypeptide binding]; other site 1167634013850 glutathionine S-transferase; Provisional; Region: PRK10542 1167634013851 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1167634013852 C-terminal domain interface [polypeptide binding]; other site 1167634013853 GSH binding site (G-site) [chemical binding]; other site 1167634013854 dimer interface [polypeptide binding]; other site 1167634013855 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1167634013856 dimer interface [polypeptide binding]; other site 1167634013857 N-terminal domain interface [polypeptide binding]; other site 1167634013858 substrate binding pocket (H-site) [chemical binding]; other site 1167634013859 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1167634013860 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1167634013861 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1167634013862 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634013863 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1167634013864 dimer interface [polypeptide binding]; other site 1167634013865 N-terminal domain interface [polypeptide binding]; other site 1167634013866 substrate binding pocket (H-site) [chemical binding]; other site 1167634013867 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634013868 EamA-like transporter family; Region: EamA; pfam00892 1167634013869 EamA-like transporter family; Region: EamA; pfam00892 1167634013870 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1167634013871 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1167634013872 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 1167634013873 putative NAD(P) binding site [chemical binding]; other site 1167634013874 catalytic Zn binding site [ion binding]; other site 1167634013875 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634013876 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1167634013877 putative ligand binding site [chemical binding]; other site 1167634013878 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634013879 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1167634013880 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634013881 agmatinase; Region: agmatinase; TIGR01230 1167634013882 Arginase family; Region: Arginase; cd09989 1167634013883 active site 1167634013884 Mn binding site [ion binding]; other site 1167634013885 oligomer interface [polypeptide binding]; other site 1167634013886 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1167634013887 PAS fold; Region: PAS; pfam00989 1167634013888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634013889 putative active site [active] 1167634013890 heme pocket [chemical binding]; other site 1167634013891 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634013892 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634013893 metal binding site [ion binding]; metal-binding site 1167634013894 active site 1167634013895 I-site; other site 1167634013896 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1167634013897 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634013898 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1167634013899 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634013900 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1167634013901 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1167634013902 putative active site [active] 1167634013903 putative metal binding site [ion binding]; other site 1167634013904 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1167634013905 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1167634013906 phosphate binding site [ion binding]; other site 1167634013907 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1167634013908 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1167634013909 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634013910 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634013911 ABC transporter; Region: ABC_tran_2; pfam12848 1167634013912 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634013913 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1167634013914 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634013915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634013916 active site 1167634013917 phosphorylation site [posttranslational modification] 1167634013918 intermolecular recognition site; other site 1167634013919 dimerization interface [polypeptide binding]; other site 1167634013920 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634013921 DNA binding site [nucleotide binding] 1167634013922 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1167634013923 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1167634013924 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1167634013925 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634013926 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1167634013927 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1167634013928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634013929 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634013930 active site 1167634013931 phosphorylation site [posttranslational modification] 1167634013932 intermolecular recognition site; other site 1167634013933 dimerization interface [polypeptide binding]; other site 1167634013934 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634013935 conserved hypothetical protein; Region: TIGR02231 1167634013936 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1167634013937 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1167634013938 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1167634013939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634013940 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1167634013941 putative dimerization interface [polypeptide binding]; other site 1167634013942 putative substrate binding pocket [chemical binding]; other site 1167634013943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634013944 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634013945 putative substrate translocation pore; other site 1167634013946 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1167634013947 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634013948 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1167634013949 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1167634013950 GAF domain; Region: GAF; pfam01590 1167634013951 PAS domain S-box; Region: sensory_box; TIGR00229 1167634013952 PAS domain; Region: PAS; smart00091 1167634013953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1167634013954 putative active site [active] 1167634013955 heme pocket [chemical binding]; other site 1167634013956 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1167634013957 PAS domain S-box; Region: sensory_box; TIGR00229 1167634013958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634013959 putative active site [active] 1167634013960 heme pocket [chemical binding]; other site 1167634013961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634013962 dimer interface [polypeptide binding]; other site 1167634013963 phosphorylation site [posttranslational modification] 1167634013964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634013965 ATP binding site [chemical binding]; other site 1167634013966 Mg2+ binding site [ion binding]; other site 1167634013967 G-X-G motif; other site 1167634013968 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634013969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634013970 active site 1167634013971 phosphorylation site [posttranslational modification] 1167634013972 intermolecular recognition site; other site 1167634013973 dimerization interface [polypeptide binding]; other site 1167634013974 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1167634013975 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1167634013976 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1167634013977 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1167634013978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634013979 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1167634013980 Walker A motif; other site 1167634013981 ATP binding site [chemical binding]; other site 1167634013982 Walker B motif; other site 1167634013983 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1167634013984 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1167634013985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634013986 active site 1167634013987 phosphorylation site [posttranslational modification] 1167634013988 intermolecular recognition site; other site 1167634013989 dimerization interface [polypeptide binding]; other site 1167634013990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634013991 Walker A motif; other site 1167634013992 ATP binding site [chemical binding]; other site 1167634013993 Walker B motif; other site 1167634013994 arginine finger; other site 1167634013995 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1167634013996 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1167634013997 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1167634013998 short chain dehydrogenase; Provisional; Region: PRK06701 1167634013999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634014000 NAD(P) binding site [chemical binding]; other site 1167634014001 active site 1167634014002 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1167634014003 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1167634014004 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 1167634014005 active site 1167634014006 DNA binding site [nucleotide binding] 1167634014007 Int/Topo IB signature motif; other site 1167634014008 catalytic residues [active] 1167634014009 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1167634014010 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1167634014011 proposed catalytic triad [active] 1167634014012 conserved cys residue [active] 1167634014013 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 1167634014014 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1167634014015 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1167634014016 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1167634014017 putative ligand binding site [chemical binding]; other site 1167634014018 NAD binding site [chemical binding]; other site 1167634014019 catalytic site [active] 1167634014020 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1167634014021 Ligand Binding Site [chemical binding]; other site 1167634014022 Predicted membrane protein [Function unknown]; Region: COG1289 1167634014023 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1167634014024 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1167634014025 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634014026 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1167634014027 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634014028 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634014029 N-terminal plug; other site 1167634014030 ligand-binding site [chemical binding]; other site 1167634014031 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1167634014032 MgtC family; Region: MgtC; pfam02308 1167634014033 Cytochrome c; Region: Cytochrom_C; cl11414 1167634014034 Cytochrome c; Region: Cytochrom_C; cl11414 1167634014035 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1167634014036 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634014037 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1167634014038 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1167634014039 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1167634014040 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1167634014041 Transporter associated domain; Region: CorC_HlyC; smart01091 1167634014042 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1167634014043 Surface antigen; Region: Bac_surface_Ag; pfam01103 1167634014044 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1167634014045 dimerization interface [polypeptide binding]; other site 1167634014046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634014047 dimer interface [polypeptide binding]; other site 1167634014048 phosphorylation site [posttranslational modification] 1167634014049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634014050 ATP binding site [chemical binding]; other site 1167634014051 Mg2+ binding site [ion binding]; other site 1167634014052 G-X-G motif; other site 1167634014053 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1167634014054 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1167634014055 Chromate transporter; Region: Chromate_transp; pfam02417 1167634014056 enoyl-CoA hydratase; Validated; Region: PRK08139 1167634014057 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634014058 substrate binding site [chemical binding]; other site 1167634014059 oxyanion hole (OAH) forming residues; other site 1167634014060 trimer interface [polypeptide binding]; other site 1167634014061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634014062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634014063 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634014064 dimerization interface [polypeptide binding]; other site 1167634014065 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1167634014066 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1167634014067 putative substrate translocation pore; other site 1167634014068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1167634014069 Rdx family; Region: Rdx; cl01407 1167634014070 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1167634014071 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1167634014072 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1167634014073 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1167634014074 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1167634014075 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1167634014076 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1167634014077 Walker A motif; other site 1167634014078 ATP binding site [chemical binding]; other site 1167634014079 Walker B motif; other site 1167634014080 type II secretion system protein F; Region: GspF; TIGR02120 1167634014081 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1167634014082 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1167634014083 PBP superfamily domain; Region: PBP_like_2; cl17296 1167634014084 PBP superfamily domain; Region: PBP_like_2; cl17296 1167634014085 PBP superfamily domain; Region: PBP_like_2; cl17296 1167634014086 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1167634014087 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 1167634014088 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634014089 TonB C terminal; Region: TonB_2; pfam13103 1167634014090 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1167634014091 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634014092 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634014093 DNA binding residues [nucleotide binding] 1167634014094 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634014095 FecR protein; Region: FecR; pfam04773 1167634014096 Transposase domain (DUF772); Region: DUF772; pfam05598 1167634014097 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1167634014098 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1167634014099 DNA binding residues [nucleotide binding] 1167634014100 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1167634014101 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1167634014102 type II secretion system protein I; Region: gspI; TIGR01707 1167634014103 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1167634014104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1167634014105 SnoaL-like domain; Region: SnoaL_2; pfam12680 1167634014106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634014107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634014108 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1167634014109 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634014110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634014111 metal binding site [ion binding]; metal-binding site 1167634014112 active site 1167634014113 I-site; other site 1167634014114 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1167634014115 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1167634014116 DNA binding residues [nucleotide binding] 1167634014117 dimer interface [polypeptide binding]; other site 1167634014118 [2Fe-2S] cluster binding site [ion binding]; other site 1167634014119 Predicted membrane protein [Function unknown]; Region: COG2259 1167634014120 Cache domain; Region: Cache_1; pfam02743 1167634014121 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634014122 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634014123 metal binding site [ion binding]; metal-binding site 1167634014124 active site 1167634014125 I-site; other site 1167634014126 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1167634014127 active site 1167634014128 DNA binding site [nucleotide binding] 1167634014129 Int/Topo IB signature motif; other site 1167634014130 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1167634014131 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1167634014132 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634014133 Walker A/P-loop; other site 1167634014134 ATP binding site [chemical binding]; other site 1167634014135 Q-loop/lid; other site 1167634014136 ABC transporter signature motif; other site 1167634014137 Walker B; other site 1167634014138 D-loop; other site 1167634014139 H-loop/switch region; other site 1167634014140 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634014141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634014142 ABC-ATPase subunit interface; other site 1167634014143 putative PBP binding loops; other site 1167634014144 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1167634014145 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634014146 substrate binding pocket [chemical binding]; other site 1167634014147 membrane-bound complex binding site; other site 1167634014148 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1167634014149 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1167634014150 tetramer interface [polypeptide binding]; other site 1167634014151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634014152 catalytic residue [active] 1167634014153 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1167634014154 Sel1-like repeats; Region: SEL1; smart00671 1167634014155 Sel1-like repeats; Region: SEL1; smart00671 1167634014156 Sel1-like repeats; Region: SEL1; smart00671 1167634014157 Sel1-like repeats; Region: SEL1; smart00671 1167634014158 Sel1-like repeats; Region: SEL1; smart00671 1167634014159 Sel1-like repeats; Region: SEL1; smart00671 1167634014160 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1167634014161 Sel1-like repeats; Region: SEL1; smart00671 1167634014162 Sel1-like repeats; Region: SEL1; smart00671 1167634014163 Sel1-like repeats; Region: SEL1; smart00671 1167634014164 C-terminal peptidase (prc); Region: prc; TIGR00225 1167634014165 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1167634014166 protein binding site [polypeptide binding]; other site 1167634014167 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1167634014168 Catalytic dyad [active] 1167634014169 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1167634014170 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1167634014171 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1167634014172 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1167634014173 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1167634014174 RNA binding surface [nucleotide binding]; other site 1167634014175 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1167634014176 active site 1167634014177 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1167634014178 dimer interface [polypeptide binding]; other site 1167634014179 catalytic triad [active] 1167634014180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1167634014181 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1167634014182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634014183 S-adenosylmethionine binding site [chemical binding]; other site 1167634014184 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1167634014185 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1167634014186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634014187 non-specific DNA binding site [nucleotide binding]; other site 1167634014188 salt bridge; other site 1167634014189 sequence-specific DNA binding site [nucleotide binding]; other site 1167634014190 Cupin domain; Region: Cupin_2; pfam07883 1167634014191 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1167634014192 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1167634014193 active site 1167634014194 putative substrate binding pocket [chemical binding]; other site 1167634014195 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634014196 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1167634014197 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634014198 Walker A/P-loop; other site 1167634014199 ATP binding site [chemical binding]; other site 1167634014200 Q-loop/lid; other site 1167634014201 ABC transporter signature motif; other site 1167634014202 Walker B; other site 1167634014203 D-loop; other site 1167634014204 H-loop/switch region; other site 1167634014205 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1167634014206 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1167634014207 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634014208 Walker A/P-loop; other site 1167634014209 ATP binding site [chemical binding]; other site 1167634014210 Q-loop/lid; other site 1167634014211 ABC transporter signature motif; other site 1167634014212 Walker B; other site 1167634014213 D-loop; other site 1167634014214 H-loop/switch region; other site 1167634014215 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1167634014216 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1167634014217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634014218 dimer interface [polypeptide binding]; other site 1167634014219 conserved gate region; other site 1167634014220 putative PBP binding loops; other site 1167634014221 ABC-ATPase subunit interface; other site 1167634014222 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634014223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634014224 dimer interface [polypeptide binding]; other site 1167634014225 conserved gate region; other site 1167634014226 putative PBP binding loops; other site 1167634014227 ABC-ATPase subunit interface; other site 1167634014228 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1167634014229 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1167634014230 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1167634014231 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1167634014232 MlrC C-terminus; Region: MlrC_C; pfam07171 1167634014233 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1167634014234 homotrimer interaction site [polypeptide binding]; other site 1167634014235 putative active site [active] 1167634014236 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1167634014237 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1167634014238 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634014239 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1167634014240 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1167634014241 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1167634014242 putative NAD(P) binding site [chemical binding]; other site 1167634014243 active site 1167634014244 DoxX-like family; Region: DoxX_3; pfam13781 1167634014245 Predicted transcriptional regulators [Transcription]; Region: COG1510 1167634014246 MarR family; Region: MarR_2; pfam12802 1167634014247 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1167634014248 C-terminal domain interface [polypeptide binding]; other site 1167634014249 GSH binding site (G-site) [chemical binding]; other site 1167634014250 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634014251 dimer interface [polypeptide binding]; other site 1167634014252 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1167634014253 dimer interface [polypeptide binding]; other site 1167634014254 N-terminal domain interface [polypeptide binding]; other site 1167634014255 substrate binding pocket (H-site) [chemical binding]; other site 1167634014256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634014257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634014258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634014259 dimerization interface [polypeptide binding]; other site 1167634014260 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1167634014261 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1167634014262 active site 1167634014263 Zn binding site [ion binding]; other site 1167634014264 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634014265 malate:quinone oxidoreductase; Validated; Region: PRK05257 1167634014266 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1167634014267 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1167634014268 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1167634014269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634014270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634014271 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1167634014272 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634014273 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1167634014274 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1167634014275 N-terminal domain interface [polypeptide binding]; other site 1167634014276 dimer interface [polypeptide binding]; other site 1167634014277 substrate binding pocket (H-site) [chemical binding]; other site 1167634014278 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1167634014279 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 1167634014280 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1167634014281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634014282 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1167634014283 arsenical-resistance protein; Region: acr3; TIGR00832 1167634014284 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1167634014285 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1167634014286 active site 1167634014287 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634014288 putative DNA binding site [nucleotide binding]; other site 1167634014289 putative Zn2+ binding site [ion binding]; other site 1167634014290 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1167634014291 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1167634014292 putative dimer interface [polypeptide binding]; other site 1167634014293 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1167634014294 BON domain; Region: BON; pfam04972 1167634014295 BON domain; Region: BON; pfam04972 1167634014296 BON domain; Region: BON; pfam04972 1167634014297 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1167634014298 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1167634014299 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1167634014300 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1167634014301 BON domain; Region: BON; pfam04972 1167634014302 BON domain; Region: BON; pfam04972 1167634014303 CHAD domain; Region: CHAD; pfam05235 1167634014304 ribonucleotide reductase-like protein; Provisional; Region: PRK06948 1167634014305 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1167634014306 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1167634014307 active site 1167634014308 dimer interface [polypeptide binding]; other site 1167634014309 effector binding site; other site 1167634014310 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 1167634014311 putative amphipathic alpha helix; other site 1167634014312 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1167634014313 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1167634014314 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1167634014315 Ligand Binding Site [chemical binding]; other site 1167634014316 Predicted membrane protein [Function unknown]; Region: COG3174 1167634014317 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1167634014318 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1167634014319 ligand binding site [chemical binding]; other site 1167634014320 flexible hinge region; other site 1167634014321 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1167634014322 putative switch regulator; other site 1167634014323 non-specific DNA interactions [nucleotide binding]; other site 1167634014324 DNA binding site [nucleotide binding] 1167634014325 sequence specific DNA binding site [nucleotide binding]; other site 1167634014326 putative cAMP binding site [chemical binding]; other site 1167634014327 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634014328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634014329 active site 1167634014330 phosphorylation site [posttranslational modification] 1167634014331 intermolecular recognition site; other site 1167634014332 dimerization interface [polypeptide binding]; other site 1167634014333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634014334 DNA binding residues [nucleotide binding] 1167634014335 dimerization interface [polypeptide binding]; other site 1167634014336 PAS domain S-box; Region: sensory_box; TIGR00229 1167634014337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634014338 putative active site [active] 1167634014339 heme pocket [chemical binding]; other site 1167634014340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1167634014341 Histidine kinase; Region: HisKA_3; pfam07730 1167634014342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634014343 ATP binding site [chemical binding]; other site 1167634014344 Mg2+ binding site [ion binding]; other site 1167634014345 G-X-G motif; other site 1167634014346 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1167634014347 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1167634014348 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1167634014349 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1167634014350 Beta-Casp domain; Region: Beta-Casp; smart01027 1167634014351 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1167634014352 putative phosphoketolase; Provisional; Region: PRK05261 1167634014353 XFP N-terminal domain; Region: XFP_N; pfam09364 1167634014354 XFP C-terminal domain; Region: XFP_C; pfam09363 1167634014355 hypothetical protein; Provisional; Region: PRK06132 1167634014356 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1167634014357 Ligand Binding Site [chemical binding]; other site 1167634014358 Universal stress protein family; Region: Usp; pfam00582 1167634014359 Ligand Binding Site [chemical binding]; other site 1167634014360 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1167634014361 Ligand Binding Site [chemical binding]; other site 1167634014362 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1167634014363 Ligand Binding Site [chemical binding]; other site 1167634014364 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1167634014365 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1167634014366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1167634014367 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634014368 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634014369 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634014370 N-terminal plug; other site 1167634014371 ligand-binding site [chemical binding]; other site 1167634014372 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634014373 FecR protein; Region: FecR; pfam04773 1167634014374 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1167634014375 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1167634014376 DNA binding residues [nucleotide binding] 1167634014377 fec operon regulator FecR; Reviewed; Region: PRK09774 1167634014378 FecR protein; Region: FecR; pfam04773 1167634014379 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634014380 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634014381 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634014382 N-terminal plug; other site 1167634014383 ligand-binding site [chemical binding]; other site 1167634014384 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1167634014385 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634014386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634014387 DNA binding residues [nucleotide binding] 1167634014388 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634014389 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634014390 Walker A/P-loop; other site 1167634014391 ATP binding site [chemical binding]; other site 1167634014392 Q-loop/lid; other site 1167634014393 ABC transporter signature motif; other site 1167634014394 Walker B; other site 1167634014395 D-loop; other site 1167634014396 H-loop/switch region; other site 1167634014397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634014398 dimer interface [polypeptide binding]; other site 1167634014399 conserved gate region; other site 1167634014400 putative PBP binding loops; other site 1167634014401 ABC-ATPase subunit interface; other site 1167634014402 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1167634014403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1167634014404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634014405 putative PBP binding loops; other site 1167634014406 dimer interface [polypeptide binding]; other site 1167634014407 ABC-ATPase subunit interface; other site 1167634014408 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1167634014409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634014410 substrate binding pocket [chemical binding]; other site 1167634014411 membrane-bound complex binding site; other site 1167634014412 hinge residues; other site 1167634014413 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1167634014414 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1167634014415 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634014416 catalytic residue [active] 1167634014417 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1167634014418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634014419 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1167634014420 putative dimerization interface [polypeptide binding]; other site 1167634014421 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634014422 N-terminal plug; other site 1167634014423 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1167634014424 ligand-binding site [chemical binding]; other site 1167634014425 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634014426 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1167634014427 Walker A/P-loop; other site 1167634014428 ATP binding site [chemical binding]; other site 1167634014429 Q-loop/lid; other site 1167634014430 ABC transporter signature motif; other site 1167634014431 Walker B; other site 1167634014432 D-loop; other site 1167634014433 H-loop/switch region; other site 1167634014434 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634014435 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634014436 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1167634014437 Walker A/P-loop; other site 1167634014438 ATP binding site [chemical binding]; other site 1167634014439 Q-loop/lid; other site 1167634014440 ABC transporter signature motif; other site 1167634014441 Walker B; other site 1167634014442 D-loop; other site 1167634014443 H-loop/switch region; other site 1167634014444 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634014445 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1167634014446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634014447 dimer interface [polypeptide binding]; other site 1167634014448 conserved gate region; other site 1167634014449 putative PBP binding loops; other site 1167634014450 ABC-ATPase subunit interface; other site 1167634014451 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634014452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1167634014453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634014454 putative PBP binding loops; other site 1167634014455 ABC-ATPase subunit interface; other site 1167634014456 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1167634014457 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1167634014458 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1167634014459 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1167634014460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634014461 catalytic residue [active] 1167634014462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634014463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634014464 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1167634014465 putative dimerization interface [polypeptide binding]; other site 1167634014466 Isochorismatase family; Region: Isochorismatase; pfam00857 1167634014467 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1167634014468 catalytic triad [active] 1167634014469 dimer interface [polypeptide binding]; other site 1167634014470 conserved cis-peptide bond; other site 1167634014471 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1167634014472 putative active site [active] 1167634014473 putative metal binding site [ion binding]; other site 1167634014474 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1167634014475 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1167634014476 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634014477 substrate binding pocket [chemical binding]; other site 1167634014478 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1167634014479 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1167634014480 membrane-bound complex binding site; other site 1167634014481 hinge residues; other site 1167634014482 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634014483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1167634014484 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634014485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634014486 putative PBP binding loops; other site 1167634014487 ABC-ATPase subunit interface; other site 1167634014488 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1167634014489 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634014490 Walker A/P-loop; other site 1167634014491 ATP binding site [chemical binding]; other site 1167634014492 Q-loop/lid; other site 1167634014493 ABC transporter signature motif; other site 1167634014494 Walker B; other site 1167634014495 D-loop; other site 1167634014496 H-loop/switch region; other site 1167634014497 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1167634014498 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1167634014499 active site 1167634014500 non-prolyl cis peptide bond; other site 1167634014501 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1167634014502 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1167634014503 catalytic triad [active] 1167634014504 CopC domain; Region: CopC; pfam04234 1167634014505 ProQ/FINO family; Region: ProQ; pfam04352 1167634014506 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 1167634014507 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634014508 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1167634014509 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1167634014510 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1167634014511 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1167634014512 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1167634014513 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1167634014514 putative active site [active] 1167634014515 catalytic residue [active] 1167634014516 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1167634014517 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1167634014518 dimer interface [polypeptide binding]; other site 1167634014519 NADP binding site [chemical binding]; other site 1167634014520 catalytic residues [active] 1167634014521 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634014522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634014523 dimer interface [polypeptide binding]; other site 1167634014524 phosphorylation site [posttranslational modification] 1167634014525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634014526 ATP binding site [chemical binding]; other site 1167634014527 Mg2+ binding site [ion binding]; other site 1167634014528 G-X-G motif; other site 1167634014529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634014530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634014531 active site 1167634014532 phosphorylation site [posttranslational modification] 1167634014533 intermolecular recognition site; other site 1167634014534 dimerization interface [polypeptide binding]; other site 1167634014535 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1167634014536 DNA binding site [nucleotide binding] 1167634014537 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1167634014538 putative ligand binding residues [chemical binding]; other site 1167634014539 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1167634014540 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1167634014541 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1167634014542 ABC-ATPase subunit interface; other site 1167634014543 dimer interface [polypeptide binding]; other site 1167634014544 putative PBP binding regions; other site 1167634014545 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1167634014546 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1167634014547 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1167634014548 Walker A/P-loop; other site 1167634014549 ATP binding site [chemical binding]; other site 1167634014550 Q-loop/lid; other site 1167634014551 ABC transporter signature motif; other site 1167634014552 Walker B; other site 1167634014553 D-loop; other site 1167634014554 H-loop/switch region; other site 1167634014555 threonine dehydratase; Reviewed; Region: PRK09224 1167634014556 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1167634014557 tetramer interface [polypeptide binding]; other site 1167634014558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634014559 catalytic residue [active] 1167634014560 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1167634014561 putative Ile/Val binding site [chemical binding]; other site 1167634014562 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1167634014563 putative Ile/Val binding site [chemical binding]; other site 1167634014564 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634014565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634014566 DNA binding site [nucleotide binding] 1167634014567 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1167634014568 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1167634014569 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1167634014570 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1167634014571 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1167634014572 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1167634014573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1167634014574 Walker A/P-loop; other site 1167634014575 ATP binding site [chemical binding]; other site 1167634014576 Q-loop/lid; other site 1167634014577 ABC transporter signature motif; other site 1167634014578 Walker B; other site 1167634014579 D-loop; other site 1167634014580 H-loop/switch region; other site 1167634014581 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1167634014582 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1167634014583 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1167634014584 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1167634014585 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1167634014586 IucA / IucC family; Region: IucA_IucC; pfam04183 1167634014587 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1167634014588 siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950 1167634014589 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1167634014590 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1167634014591 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1167634014592 [2Fe-2S] cluster binding site [ion binding]; other site 1167634014593 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1167634014594 alpha subunit interface [polypeptide binding]; other site 1167634014595 active site 1167634014596 substrate binding site [chemical binding]; other site 1167634014597 Fe binding site [ion binding]; other site 1167634014598 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634014599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634014600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634014601 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634014602 putative substrate translocation pore; other site 1167634014603 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634014604 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634014605 N-terminal plug; other site 1167634014606 ligand-binding site [chemical binding]; other site 1167634014607 ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592 1167634014608 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1167634014609 intersubunit interface [polypeptide binding]; other site 1167634014610 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1167634014611 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1167634014612 ABC-ATPase subunit interface; other site 1167634014613 dimer interface [polypeptide binding]; other site 1167634014614 putative PBP binding regions; other site 1167634014615 FecCD transport family; Region: FecCD; pfam01032 1167634014616 ABC-ATPase subunit interface; other site 1167634014617 dimer interface [polypeptide binding]; other site 1167634014618 putative PBP binding regions; other site 1167634014619 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1167634014620 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1167634014621 Walker A/P-loop; other site 1167634014622 ATP binding site [chemical binding]; other site 1167634014623 Q-loop/lid; other site 1167634014624 ABC transporter signature motif; other site 1167634014625 Walker B; other site 1167634014626 D-loop; other site 1167634014627 H-loop/switch region; other site 1167634014628 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634014629 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634014630 Walker A/P-loop; other site 1167634014631 ATP binding site [chemical binding]; other site 1167634014632 Q-loop/lid; other site 1167634014633 ABC transporter signature motif; other site 1167634014634 Walker B; other site 1167634014635 D-loop; other site 1167634014636 H-loop/switch region; other site 1167634014637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634014638 dimer interface [polypeptide binding]; other site 1167634014639 conserved gate region; other site 1167634014640 putative PBP binding loops; other site 1167634014641 ABC-ATPase subunit interface; other site 1167634014642 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634014643 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634014644 substrate binding pocket [chemical binding]; other site 1167634014645 membrane-bound complex binding site; other site 1167634014646 hinge residues; other site 1167634014647 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1167634014648 FMN binding site [chemical binding]; other site 1167634014649 substrate binding site [chemical binding]; other site 1167634014650 putative catalytic residue [active] 1167634014651 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1167634014652 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1167634014653 catalytic residues [active] 1167634014654 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1167634014655 lipid-transfer protein; Provisional; Region: PRK07855 1167634014656 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1167634014657 active site 1167634014658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634014659 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634014660 putative substrate translocation pore; other site 1167634014661 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1167634014662 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634014663 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1167634014664 acyl-activating enzyme (AAE) consensus motif; other site 1167634014665 putative AMP binding site [chemical binding]; other site 1167634014666 putative active site [active] 1167634014667 putative CoA binding site [chemical binding]; other site 1167634014668 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634014669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634014670 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1167634014671 substrate binding pocket [chemical binding]; other site 1167634014672 dimerization interface [polypeptide binding]; other site 1167634014673 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1167634014674 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 1167634014675 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1167634014676 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634014677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634014678 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634014679 dimerization interface [polypeptide binding]; other site 1167634014680 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1167634014681 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1167634014682 Cl- selectivity filter; other site 1167634014683 Cl- binding residues [ion binding]; other site 1167634014684 pore gating glutamate residue; other site 1167634014685 dimer interface [polypeptide binding]; other site 1167634014686 FOG: CBS domain [General function prediction only]; Region: COG0517 1167634014687 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1167634014688 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1167634014689 MarR family; Region: MarR_2; pfam12802 1167634014690 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 1167634014691 HPP family; Region: HPP; pfam04982 1167634014692 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1167634014693 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 1167634014694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634014695 dimer interface [polypeptide binding]; other site 1167634014696 phosphorylation site [posttranslational modification] 1167634014697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634014698 ATP binding site [chemical binding]; other site 1167634014699 Mg2+ binding site [ion binding]; other site 1167634014700 G-X-G motif; other site 1167634014701 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1167634014702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634014703 active site 1167634014704 phosphorylation site [posttranslational modification] 1167634014705 intermolecular recognition site; other site 1167634014706 dimerization interface [polypeptide binding]; other site 1167634014707 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634014708 DNA binding residues [nucleotide binding] 1167634014709 dimerization interface [polypeptide binding]; other site 1167634014710 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1167634014711 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1167634014712 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1167634014713 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1167634014714 active site residue [active] 1167634014715 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1167634014716 active site residue [active] 1167634014717 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1167634014718 active site residue [active] 1167634014719 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1167634014720 active site residue [active] 1167634014721 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 1167634014722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634014723 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1167634014724 substrate binding site [chemical binding]; other site 1167634014725 dimerization interface [polypeptide binding]; other site 1167634014726 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634014727 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1167634014728 active site 1167634014729 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1167634014730 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1167634014731 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634014732 catalytic residue [active] 1167634014733 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1167634014734 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634014735 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634014736 Walker A/P-loop; other site 1167634014737 ATP binding site [chemical binding]; other site 1167634014738 Q-loop/lid; other site 1167634014739 ABC transporter signature motif; other site 1167634014740 Walker B; other site 1167634014741 D-loop; other site 1167634014742 H-loop/switch region; other site 1167634014743 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1167634014744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634014745 dimer interface [polypeptide binding]; other site 1167634014746 conserved gate region; other site 1167634014747 putative PBP binding loops; other site 1167634014748 ABC-ATPase subunit interface; other site 1167634014749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634014750 dimer interface [polypeptide binding]; other site 1167634014751 conserved gate region; other site 1167634014752 putative PBP binding loops; other site 1167634014753 ABC-ATPase subunit interface; other site 1167634014754 aspartate aminotransferase; Provisional; Region: PRK06107 1167634014755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634014756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634014757 homodimer interface [polypeptide binding]; other site 1167634014758 catalytic residue [active] 1167634014759 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634014760 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634014761 substrate binding pocket [chemical binding]; other site 1167634014762 membrane-bound complex binding site; other site 1167634014763 hinge residues; other site 1167634014764 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634014765 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634014766 substrate binding pocket [chemical binding]; other site 1167634014767 membrane-bound complex binding site; other site 1167634014768 hinge residues; other site 1167634014769 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634014770 haloalkane dehalogenase; Provisional; Region: PRK03592 1167634014771 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1167634014772 putative substrate binding pocket [chemical binding]; other site 1167634014773 AC domain interface; other site 1167634014774 catalytic triad [active] 1167634014775 AB domain interface; other site 1167634014776 interchain disulfide; other site 1167634014777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634014778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634014779 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1167634014780 substrate binding pocket [chemical binding]; other site 1167634014781 dimerization interface [polypeptide binding]; other site 1167634014782 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1167634014783 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1167634014784 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1167634014785 homotrimer interaction site [polypeptide binding]; other site 1167634014786 putative active site [active] 1167634014787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634014788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634014789 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1167634014790 putative effector binding pocket; other site 1167634014791 putative dimerization interface [polypeptide binding]; other site 1167634014792 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1167634014793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634014794 S-adenosylmethionine binding site [chemical binding]; other site 1167634014795 transglutaminase; Provisional; Region: tgl; PRK03187 1167634014796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634014797 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1167634014798 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1167634014799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634014800 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634014801 dimerization interface [polypeptide binding]; other site 1167634014802 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1167634014803 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1167634014804 octamer interface [polypeptide binding]; other site 1167634014805 active site 1167634014806 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634014807 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634014808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634014809 DNA-binding site [nucleotide binding]; DNA binding site 1167634014810 FCD domain; Region: FCD; pfam07729 1167634014811 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1167634014812 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1167634014813 inhibitor site; inhibition site 1167634014814 active site 1167634014815 dimer interface [polypeptide binding]; other site 1167634014816 catalytic residue [active] 1167634014817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634014818 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634014819 hypothetical protein; Validated; Region: PRK08245 1167634014820 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 1167634014821 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634014822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634014823 DNA-binding site [nucleotide binding]; DNA binding site 1167634014824 FCD domain; Region: FCD; pfam07729 1167634014825 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1167634014826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634014827 Coenzyme A binding pocket [chemical binding]; other site 1167634014828 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634014829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634014830 dimer interface [polypeptide binding]; other site 1167634014831 conserved gate region; other site 1167634014832 ABC-ATPase subunit interface; other site 1167634014833 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1167634014834 NMT1-like family; Region: NMT1_2; pfam13379 1167634014835 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1167634014836 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634014837 Walker A/P-loop; other site 1167634014838 ATP binding site [chemical binding]; other site 1167634014839 Q-loop/lid; other site 1167634014840 ABC transporter signature motif; other site 1167634014841 Walker B; other site 1167634014842 D-loop; other site 1167634014843 H-loop/switch region; other site 1167634014844 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634014845 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634014846 active site 1167634014847 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1167634014848 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1167634014849 Cupin; Region: Cupin_6; pfam12852 1167634014850 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634014851 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634014852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634014853 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1167634014854 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634014855 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 1167634014856 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1167634014857 homodimer interface [polypeptide binding]; other site 1167634014858 substrate-cofactor binding pocket; other site 1167634014859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634014860 catalytic residue [active] 1167634014861 SCP-2 sterol transfer family; Region: SCP2; cl01225 1167634014862 putative protease; Provisional; Region: PRK15447 1167634014863 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1167634014864 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1167634014865 Peptidase family U32; Region: Peptidase_U32; pfam01136 1167634014866 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634014867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634014868 active site 1167634014869 phosphorylation site [posttranslational modification] 1167634014870 intermolecular recognition site; other site 1167634014871 dimerization interface [polypeptide binding]; other site 1167634014872 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634014873 DNA binding residues [nucleotide binding] 1167634014874 dimerization interface [polypeptide binding]; other site 1167634014875 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 1167634014876 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1167634014877 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634014878 dimerization interface [polypeptide binding]; other site 1167634014879 GAF domain; Region: GAF_3; pfam13492 1167634014880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634014881 ATP binding site [chemical binding]; other site 1167634014882 Mg2+ binding site [ion binding]; other site 1167634014883 G-X-G motif; other site 1167634014884 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1167634014885 Walker A motif; other site 1167634014886 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1167634014887 active site clefts [active] 1167634014888 zinc binding site [ion binding]; other site 1167634014889 dimer interface [polypeptide binding]; other site 1167634014890 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1167634014891 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1167634014892 FeS/SAM binding site; other site 1167634014893 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1167634014894 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 1167634014895 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1167634014896 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1167634014897 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1167634014898 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1167634014899 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1167634014900 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1167634014901 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1167634014902 [4Fe-4S] binding site [ion binding]; other site 1167634014903 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1167634014904 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1167634014905 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1167634014906 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1167634014907 molybdopterin cofactor binding site; other site 1167634014908 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1167634014909 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1167634014910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634014911 putative substrate translocation pore; other site 1167634014912 NnrS protein; Region: NnrS; pfam05940 1167634014913 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1167634014914 hypothetical protein; Provisional; Region: PRK07236 1167634014915 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634014916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634014917 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634014918 dimerization interface [polypeptide binding]; other site 1167634014919 putative effector binding pocket; other site 1167634014920 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1167634014921 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634014922 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634014923 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1167634014924 Protein export membrane protein; Region: SecD_SecF; cl14618 1167634014925 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1167634014926 Protein export membrane protein; Region: SecD_SecF; cl14618 1167634014927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634014928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634014929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634014930 dimerization interface [polypeptide binding]; other site 1167634014931 hypothetical protein; Provisional; Region: PRK07079 1167634014932 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 1167634014933 metal binding site [ion binding]; metal-binding site 1167634014934 putative dimer interface [polypeptide binding]; other site 1167634014935 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634014936 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1167634014937 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1167634014938 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1167634014939 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1167634014940 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 1167634014941 ATP cone domain; Region: ATP-cone; pfam03477 1167634014942 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1167634014943 effector binding site; other site 1167634014944 active site 1167634014945 Zn binding site [ion binding]; other site 1167634014946 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 1167634014947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1167634014948 FeS/SAM binding site; other site 1167634014949 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634014950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634014951 DNA-binding site [nucleotide binding]; DNA binding site 1167634014952 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634014953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634014954 homodimer interface [polypeptide binding]; other site 1167634014955 catalytic residue [active] 1167634014956 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1167634014957 homodimer interface [polypeptide binding]; other site 1167634014958 catalytic residues [active] 1167634014959 NAD binding site [chemical binding]; other site 1167634014960 substrate binding pocket [chemical binding]; other site 1167634014961 flexible flap; other site 1167634014962 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1167634014963 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1167634014964 FMN binding site [chemical binding]; other site 1167634014965 substrate binding site [chemical binding]; other site 1167634014966 putative catalytic residue [active] 1167634014967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634014968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634014969 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1167634014970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634014971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634014972 active site 1167634014973 phosphorylation site [posttranslational modification] 1167634014974 intermolecular recognition site; other site 1167634014975 dimerization interface [polypeptide binding]; other site 1167634014976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634014977 DNA binding site [nucleotide binding] 1167634014978 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1167634014979 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1167634014980 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 1167634014981 Moco binding site; other site 1167634014982 metal coordination site [ion binding]; other site 1167634014983 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 1167634014984 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1167634014985 SelR domain; Region: SelR; pfam01641 1167634014986 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1167634014987 Autotransporter beta-domain; Region: Autotransporter; smart00869 1167634014988 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1167634014989 Ferritin-like domain; Region: Ferritin; pfam00210 1167634014990 dimerization interface [polypeptide binding]; other site 1167634014991 DPS ferroxidase diiron center [ion binding]; other site 1167634014992 ion pore; other site 1167634014993 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1167634014994 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1167634014995 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1167634014996 active site 1167634014997 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634014998 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1167634014999 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634015000 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634015001 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1167634015002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634015003 putative substrate translocation pore; other site 1167634015004 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634015005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634015006 DNA-binding site [nucleotide binding]; DNA binding site 1167634015007 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634015008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634015009 homodimer interface [polypeptide binding]; other site 1167634015010 catalytic residue [active] 1167634015011 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634015012 EamA-like transporter family; Region: EamA; pfam00892 1167634015013 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1167634015014 carbon starvation protein A; Provisional; Region: PRK15015 1167634015015 Carbon starvation protein CstA; Region: CstA; pfam02554 1167634015016 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1167634015017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 1167634015018 Cache domain; Region: Cache_2; pfam08269 1167634015019 Histidine kinase; Region: HisKA_3; pfam07730 1167634015020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634015021 ATP binding site [chemical binding]; other site 1167634015022 Mg2+ binding site [ion binding]; other site 1167634015023 G-X-G motif; other site 1167634015024 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634015025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634015026 active site 1167634015027 phosphorylation site [posttranslational modification] 1167634015028 intermolecular recognition site; other site 1167634015029 dimerization interface [polypeptide binding]; other site 1167634015030 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634015031 DNA binding residues [nucleotide binding] 1167634015032 dimerization interface [polypeptide binding]; other site 1167634015033 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1167634015034 homodecamer interface [polypeptide binding]; other site 1167634015035 GTP cyclohydrolase I; Provisional; Region: PLN03044 1167634015036 active site 1167634015037 putative catalytic site residues [active] 1167634015038 zinc binding site [ion binding]; other site 1167634015039 GTP-CH-I/GFRP interaction surface; other site 1167634015040 EamA-like transporter family; Region: EamA; pfam00892 1167634015041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634015042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015043 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634015044 dimerization interface [polypeptide binding]; other site 1167634015045 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1167634015046 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634015047 substrate binding pocket [chemical binding]; other site 1167634015048 membrane-bound complex binding site; other site 1167634015049 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 1167634015050 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634015051 Walker A/P-loop; other site 1167634015052 ATP binding site [chemical binding]; other site 1167634015053 Q-loop/lid; other site 1167634015054 ABC transporter signature motif; other site 1167634015055 Walker B; other site 1167634015056 D-loop; other site 1167634015057 H-loop/switch region; other site 1167634015058 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634015059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634015060 dimer interface [polypeptide binding]; other site 1167634015061 conserved gate region; other site 1167634015062 putative PBP binding loops; other site 1167634015063 ABC-ATPase subunit interface; other site 1167634015064 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1167634015065 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1167634015066 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634015067 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634015068 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 1167634015069 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1167634015070 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634015071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634015072 Walker A/P-loop; other site 1167634015073 ATP binding site [chemical binding]; other site 1167634015074 Q-loop/lid; other site 1167634015075 ABC transporter signature motif; other site 1167634015076 Walker B; other site 1167634015077 D-loop; other site 1167634015078 H-loop/switch region; other site 1167634015079 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1167634015080 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634015081 DNA-binding site [nucleotide binding]; DNA binding site 1167634015082 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634015083 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634015084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634015085 homodimer interface [polypeptide binding]; other site 1167634015086 catalytic residue [active] 1167634015087 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 1167634015088 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 1167634015089 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1167634015090 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634015091 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1167634015092 intersubunit interface [polypeptide binding]; other site 1167634015093 active site 1167634015094 Zn2+ binding site [ion binding]; other site 1167634015095 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1167634015096 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1167634015097 SnoaL-like domain; Region: SnoaL_2; pfam12680 1167634015098 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1167634015099 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1167634015100 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1167634015101 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1167634015102 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1167634015103 active site 1167634015104 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1167634015105 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634015106 Walker A/P-loop; other site 1167634015107 ATP binding site [chemical binding]; other site 1167634015108 Q-loop/lid; other site 1167634015109 ABC transporter signature motif; other site 1167634015110 Walker B; other site 1167634015111 D-loop; other site 1167634015112 H-loop/switch region; other site 1167634015113 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634015114 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634015115 Walker A/P-loop; other site 1167634015116 ATP binding site [chemical binding]; other site 1167634015117 Q-loop/lid; other site 1167634015118 ABC transporter signature motif; other site 1167634015119 Walker B; other site 1167634015120 D-loop; other site 1167634015121 H-loop/switch region; other site 1167634015122 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634015123 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1167634015124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634015125 dimer interface [polypeptide binding]; other site 1167634015126 conserved gate region; other site 1167634015127 putative PBP binding loops; other site 1167634015128 ABC-ATPase subunit interface; other site 1167634015129 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634015130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634015131 dimer interface [polypeptide binding]; other site 1167634015132 conserved gate region; other site 1167634015133 putative PBP binding loops; other site 1167634015134 ABC-ATPase subunit interface; other site 1167634015135 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1167634015136 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1167634015137 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1167634015138 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 1167634015139 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1167634015140 PYR/PP interface [polypeptide binding]; other site 1167634015141 dimer interface [polypeptide binding]; other site 1167634015142 TPP binding site [chemical binding]; other site 1167634015143 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1167634015144 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 1167634015145 TPP-binding site; other site 1167634015146 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634015147 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1167634015148 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634015149 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1167634015150 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1167634015151 ATP binding site [chemical binding]; other site 1167634015152 Mg++ binding site [ion binding]; other site 1167634015153 motif III; other site 1167634015154 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634015155 nucleotide binding region [chemical binding]; other site 1167634015156 ATP-binding site [chemical binding]; other site 1167634015157 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1167634015158 putative RNA binding site [nucleotide binding]; other site 1167634015159 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1167634015160 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1167634015161 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1167634015162 active site 1167634015163 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1167634015164 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1167634015165 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1167634015166 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1167634015167 HlyD family secretion protein; Region: HlyD; pfam00529 1167634015168 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634015169 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634015170 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1167634015171 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1167634015172 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1167634015173 PYR/PP interface [polypeptide binding]; other site 1167634015174 dimer interface [polypeptide binding]; other site 1167634015175 TPP binding site [chemical binding]; other site 1167634015176 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1167634015177 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1167634015178 TPP-binding site [chemical binding]; other site 1167634015179 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634015180 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634015181 classical (c) SDRs; Region: SDR_c; cd05233 1167634015182 NAD(P) binding site [chemical binding]; other site 1167634015183 active site 1167634015184 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634015185 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1167634015186 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634015187 putative hydrolase; Provisional; Region: PRK11460 1167634015188 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1167634015189 lysine transporter; Provisional; Region: PRK10836 1167634015190 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634015191 putative CheW interface [polypeptide binding]; other site 1167634015192 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1167634015193 DNA Polymerase Y-family; Region: PolY_like; cd03468 1167634015194 DNA binding site [nucleotide binding] 1167634015195 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1167634015196 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1167634015197 putative active site [active] 1167634015198 putative PHP Thumb interface [polypeptide binding]; other site 1167634015199 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1167634015200 generic binding surface II; other site 1167634015201 generic binding surface I; other site 1167634015202 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1167634015203 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1167634015204 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1167634015205 DNA binding residues [nucleotide binding] 1167634015206 putative dimer interface [polypeptide binding]; other site 1167634015207 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1167634015208 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1167634015209 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634015210 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015211 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634015212 dimerization interface [polypeptide binding]; other site 1167634015213 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1167634015214 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1167634015215 active site 1167634015216 catalytic tetrad [active] 1167634015217 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1167634015218 nudix motif; other site 1167634015219 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1167634015220 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 1167634015221 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1167634015222 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1167634015223 active site 1167634015224 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1167634015225 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1167634015226 active site 1167634015227 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1167634015228 active site 1167634015229 short chain dehydrogenase; Provisional; Region: PRK07041 1167634015230 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1167634015231 putative NAD(P) binding site [chemical binding]; other site 1167634015232 homodimer interface [polypeptide binding]; other site 1167634015233 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1167634015234 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1167634015235 Autotransporter beta-domain; Region: Autotransporter; smart00869 1167634015236 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634015237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015238 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634015239 dimerization interface [polypeptide binding]; other site 1167634015240 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634015241 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634015242 Walker A/P-loop; other site 1167634015243 ATP binding site [chemical binding]; other site 1167634015244 Q-loop/lid; other site 1167634015245 ABC transporter signature motif; other site 1167634015246 Walker B; other site 1167634015247 D-loop; other site 1167634015248 H-loop/switch region; other site 1167634015249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634015250 dimer interface [polypeptide binding]; other site 1167634015251 conserved gate region; other site 1167634015252 putative PBP binding loops; other site 1167634015253 ABC-ATPase subunit interface; other site 1167634015254 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1167634015255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634015256 dimer interface [polypeptide binding]; other site 1167634015257 conserved gate region; other site 1167634015258 putative PBP binding loops; other site 1167634015259 ABC-ATPase subunit interface; other site 1167634015260 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634015261 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634015262 substrate binding pocket [chemical binding]; other site 1167634015263 membrane-bound complex binding site; other site 1167634015264 hinge residues; other site 1167634015265 aspartate aminotransferase; Provisional; Region: PRK06107 1167634015266 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634015267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634015268 homodimer interface [polypeptide binding]; other site 1167634015269 catalytic residue [active] 1167634015270 hypothetical protein; Validated; Region: PRK06201 1167634015271 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1167634015272 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1167634015273 Part of AAA domain; Region: AAA_19; pfam13245 1167634015274 Family description; Region: UvrD_C_2; pfam13538 1167634015275 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1167634015276 putative active site [active] 1167634015277 putative metal-binding site [ion binding]; other site 1167634015278 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634015279 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634015280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634015281 homodimer interface [polypeptide binding]; other site 1167634015282 catalytic residue [active] 1167634015283 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1167634015284 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1167634015285 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1167634015286 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1167634015287 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1167634015288 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1167634015289 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634015290 dimerization interface [polypeptide binding]; other site 1167634015291 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634015292 dimer interface [polypeptide binding]; other site 1167634015293 putative CheW interface [polypeptide binding]; other site 1167634015294 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1167634015295 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1167634015296 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1167634015297 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1167634015298 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1167634015299 MlrC C-terminus; Region: MlrC_C; pfam07171 1167634015300 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1167634015301 ANTAR domain; Region: ANTAR; pfam03861 1167634015302 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634015303 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 1167634015304 ligand binding site [chemical binding]; other site 1167634015305 regulator interaction site; other site 1167634015306 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634015307 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634015308 Walker A/P-loop; other site 1167634015309 ATP binding site [chemical binding]; other site 1167634015310 Q-loop/lid; other site 1167634015311 ABC transporter signature motif; other site 1167634015312 Walker B; other site 1167634015313 D-loop; other site 1167634015314 H-loop/switch region; other site 1167634015315 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634015316 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634015317 TM-ABC transporter signature motif; other site 1167634015318 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634015319 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634015320 Walker A/P-loop; other site 1167634015321 ATP binding site [chemical binding]; other site 1167634015322 Q-loop/lid; other site 1167634015323 ABC transporter signature motif; other site 1167634015324 Walker B; other site 1167634015325 D-loop; other site 1167634015326 H-loop/switch region; other site 1167634015327 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634015328 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634015329 TM-ABC transporter signature motif; other site 1167634015330 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634015331 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1167634015332 putative ligand binding site [chemical binding]; other site 1167634015333 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1167634015334 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 1167634015335 putative active site [active] 1167634015336 catalytic triad [active] 1167634015337 putative dimer interface [polypeptide binding]; other site 1167634015338 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1167634015339 dimer interface [polypeptide binding]; other site 1167634015340 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634015341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634015342 putative substrate translocation pore; other site 1167634015343 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1167634015344 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634015345 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634015346 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634015347 N-terminal plug; other site 1167634015348 ligand-binding site [chemical binding]; other site 1167634015349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634015350 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1167634015351 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634015352 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1167634015353 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634015354 choline dehydrogenase; Validated; Region: PRK02106 1167634015355 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1167634015356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634015357 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634015358 putative substrate translocation pore; other site 1167634015359 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1167634015360 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1167634015361 active site 1167634015362 catalytic tetrad [active] 1167634015363 Beta-lactamase; Region: Beta-lactamase; pfam00144 1167634015364 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1167634015365 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634015366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634015367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634015368 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1167634015369 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1167634015370 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1167634015371 Helix-turn-helix domain; Region: HTH_18; pfam12833 1167634015372 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1167634015373 LabA_like proteins; Region: LabA_like; cd06167 1167634015374 putative metal binding site [ion binding]; other site 1167634015375 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1167634015376 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1167634015377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1167634015378 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1167634015379 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1167634015380 ligand binding site [chemical binding]; other site 1167634015381 YCII-related domain; Region: YCII; cl00999 1167634015382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1167634015383 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1167634015384 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634015385 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1167634015386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634015387 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1167634015388 DNA binding residues [nucleotide binding] 1167634015389 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1167634015390 Helix-turn-helix domain; Region: HTH_18; pfam12833 1167634015391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634015392 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1167634015393 EamA-like transporter family; Region: EamA; pfam00892 1167634015394 EamA-like transporter family; Region: EamA; pfam00892 1167634015395 Cytochrome c; Region: Cytochrom_C; pfam00034 1167634015396 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1167634015397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634015398 motif II; other site 1167634015399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634015400 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634015401 putative substrate translocation pore; other site 1167634015402 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634015403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015404 dimerization interface [polypeptide binding]; other site 1167634015405 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1167634015406 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 1167634015407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634015408 Coenzyme A binding pocket [chemical binding]; other site 1167634015409 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634015410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015411 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634015412 dimerization interface [polypeptide binding]; other site 1167634015413 glutathionine S-transferase; Provisional; Region: PRK10542 1167634015414 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1167634015415 C-terminal domain interface [polypeptide binding]; other site 1167634015416 GSH binding site (G-site) [chemical binding]; other site 1167634015417 dimer interface [polypeptide binding]; other site 1167634015418 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1167634015419 dimer interface [polypeptide binding]; other site 1167634015420 N-terminal domain interface [polypeptide binding]; other site 1167634015421 substrate binding pocket (H-site) [chemical binding]; other site 1167634015422 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1167634015423 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1167634015424 MarR family; Region: MarR; pfam01047 1167634015425 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1167634015426 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1167634015427 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1167634015428 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1167634015429 Helix-turn-helix domain; Region: HTH_17; pfam12728 1167634015430 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 1167634015431 dimer interface [polypeptide binding]; other site 1167634015432 active site 1167634015433 coenzyme A binding site [chemical binding]; other site 1167634015434 citrylCoA binding site [chemical binding]; other site 1167634015435 Citrate synthase; Region: Citrate_synt; pfam00285 1167634015436 oxalacetate/citrate binding site [chemical binding]; other site 1167634015437 catalytic triad [active] 1167634015438 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634015439 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1167634015440 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1167634015441 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 1167634015442 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 1167634015443 Domain of unknown function (DUF802); Region: DUF802; pfam05650 1167634015444 Domain of unknown function (DUF802); Region: DUF802; pfam05650 1167634015445 Domain of unknown function (DUF802); Region: DUF802; pfam05650 1167634015446 hypothetical protein; Provisional; Region: PRK09040 1167634015447 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1167634015448 ligand binding site [chemical binding]; other site 1167634015449 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 1167634015450 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 1167634015451 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1167634015452 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1167634015453 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1167634015454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1167634015455 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1167634015456 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1167634015457 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1167634015458 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1167634015459 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1167634015460 Clp amino terminal domain; Region: Clp_N; pfam02861 1167634015461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634015462 Walker A motif; other site 1167634015463 ATP binding site [chemical binding]; other site 1167634015464 Walker B motif; other site 1167634015465 arginine finger; other site 1167634015466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634015467 Walker A motif; other site 1167634015468 ATP binding site [chemical binding]; other site 1167634015469 Walker B motif; other site 1167634015470 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1167634015471 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 1167634015472 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1167634015473 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 1167634015474 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1167634015475 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1167634015476 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 1167634015477 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1167634015478 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1167634015479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1167634015480 TPR motif; other site 1167634015481 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 1167634015482 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1167634015483 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1167634015484 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 1167634015485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1167634015486 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1167634015487 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1167634015488 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1167634015489 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1167634015490 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1167634015491 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1167634015492 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 1167634015493 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1167634015494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1167634015495 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1167634015496 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1167634015497 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1167634015498 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1167634015499 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1167634015500 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1167634015501 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1167634015502 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1167634015503 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1167634015504 type VI secretion-associated protein, BMA_A0400 family; Region: VI_minor_4; TIGR03373 1167634015505 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1167634015506 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1167634015507 ligand binding site [chemical binding]; other site 1167634015508 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1167634015509 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1167634015510 translocation protein TolB; Provisional; Region: tolB; PRK02889 1167634015511 PAAR motif; Region: PAAR_motif; pfam05488 1167634015512 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1167634015513 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1167634015514 active site 1167634015515 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 1167634015516 H+ Antiporter protein; Region: 2A0121; TIGR00900 1167634015517 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1167634015518 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634015519 putative C-terminal domain interface [polypeptide binding]; other site 1167634015520 putative GSH binding site (G-site) [chemical binding]; other site 1167634015521 putative dimer interface [polypeptide binding]; other site 1167634015522 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1167634015523 putative N-terminal domain interface [polypeptide binding]; other site 1167634015524 putative dimer interface [polypeptide binding]; other site 1167634015525 putative substrate binding pocket (H-site) [chemical binding]; other site 1167634015526 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1167634015527 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1167634015528 E-class dimer interface [polypeptide binding]; other site 1167634015529 P-class dimer interface [polypeptide binding]; other site 1167634015530 active site 1167634015531 Cu2+ binding site [ion binding]; other site 1167634015532 Zn2+ binding site [ion binding]; other site 1167634015533 Predicted membrane protein [Function unknown]; Region: COG2733 1167634015534 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634015535 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015536 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634015537 dimerization interface [polypeptide binding]; other site 1167634015538 enolase; Provisional; Region: eno; PRK00077 1167634015539 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1167634015540 dimer interface [polypeptide binding]; other site 1167634015541 metal binding site [ion binding]; metal-binding site 1167634015542 substrate binding pocket [chemical binding]; other site 1167634015543 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 1167634015544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634015545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015546 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634015547 putative effector binding pocket; other site 1167634015548 dimerization interface [polypeptide binding]; other site 1167634015549 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634015550 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1167634015551 substrate binding site [chemical binding]; other site 1167634015552 oxyanion hole (OAH) forming residues; other site 1167634015553 trimer interface [polypeptide binding]; other site 1167634015554 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1167634015555 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634015556 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634015557 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1167634015558 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1167634015559 dimer interface [polypeptide binding]; other site 1167634015560 active site 1167634015561 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1167634015562 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1167634015563 FAD binding site [chemical binding]; other site 1167634015564 substrate binding site [chemical binding]; other site 1167634015565 catalytic base [active] 1167634015566 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1167634015567 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1167634015568 active site 1167634015569 AMP-binding domain protein; Validated; Region: PRK07529 1167634015570 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634015571 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 1167634015572 acyl-activating enzyme (AAE) consensus motif; other site 1167634015573 putative AMP binding site [chemical binding]; other site 1167634015574 putative active site [active] 1167634015575 putative CoA binding site [chemical binding]; other site 1167634015576 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634015577 D-cysteine desulfhydrase; Validated; Region: PRK03910 1167634015578 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1167634015579 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634015580 catalytic residue [active] 1167634015581 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634015582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634015583 DNA-binding site [nucleotide binding]; DNA binding site 1167634015584 FCD domain; Region: FCD; pfam07729 1167634015585 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1167634015586 Ligand Binding Site [chemical binding]; other site 1167634015587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634015588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015589 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634015590 dimerization interface [polypeptide binding]; other site 1167634015591 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1167634015592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634015593 putative substrate translocation pore; other site 1167634015594 MarR family; Region: MarR_2; cl17246 1167634015595 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1167634015596 benzoate transport; Region: 2A0115; TIGR00895 1167634015597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634015598 putative substrate translocation pore; other site 1167634015599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634015600 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1167634015601 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1167634015602 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1167634015603 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1167634015604 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1167634015605 hypothetical protein; Provisional; Region: PRK06847 1167634015606 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634015607 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634015608 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1167634015609 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1167634015610 Isochorismatase family; Region: Isochorismatase; pfam00857 1167634015611 catalytic triad [active] 1167634015612 conserved cis-peptide bond; other site 1167634015613 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1167634015614 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1167634015615 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1167634015616 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1167634015617 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1167634015618 methionine gamma-lyase; Validated; Region: PRK07049 1167634015619 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1167634015620 homodimer interface [polypeptide binding]; other site 1167634015621 substrate-cofactor binding pocket; other site 1167634015622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634015623 catalytic residue [active] 1167634015624 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634015625 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1167634015626 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634015627 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1167634015628 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1167634015629 trimer interface [polypeptide binding]; other site 1167634015630 eyelet of channel; other site 1167634015631 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1167634015632 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1167634015633 Walker A/P-loop; other site 1167634015634 ATP binding site [chemical binding]; other site 1167634015635 Q-loop/lid; other site 1167634015636 ABC transporter signature motif; other site 1167634015637 Walker B; other site 1167634015638 D-loop; other site 1167634015639 H-loop/switch region; other site 1167634015640 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1167634015641 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1167634015642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634015643 dimer interface [polypeptide binding]; other site 1167634015644 conserved gate region; other site 1167634015645 putative PBP binding loops; other site 1167634015646 ABC-ATPase subunit interface; other site 1167634015647 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634015648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634015649 active site 1167634015650 phosphorylation site [posttranslational modification] 1167634015651 intermolecular recognition site; other site 1167634015652 dimerization interface [polypeptide binding]; other site 1167634015653 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634015654 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634015655 metal binding site [ion binding]; metal-binding site 1167634015656 active site 1167634015657 I-site; other site 1167634015658 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1167634015659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1167634015660 phosphorylation site [posttranslational modification] 1167634015661 intermolecular recognition site; other site 1167634015662 CheB methylesterase; Region: CheB_methylest; pfam01339 1167634015663 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1167634015664 putative binding surface; other site 1167634015665 active site 1167634015666 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1167634015667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634015668 ATP binding site [chemical binding]; other site 1167634015669 Mg2+ binding site [ion binding]; other site 1167634015670 G-X-G motif; other site 1167634015671 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1167634015672 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634015673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634015674 active site 1167634015675 phosphorylation site [posttranslational modification] 1167634015676 intermolecular recognition site; other site 1167634015677 dimerization interface [polypeptide binding]; other site 1167634015678 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1167634015679 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1167634015680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634015681 S-adenosylmethionine binding site [chemical binding]; other site 1167634015682 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1167634015683 TPR motif; other site 1167634015684 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1167634015685 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1167634015686 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1167634015687 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1167634015688 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634015689 dimerization interface [polypeptide binding]; other site 1167634015690 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634015691 dimer interface [polypeptide binding]; other site 1167634015692 putative CheW interface [polypeptide binding]; other site 1167634015693 amidase; Provisional; Region: PRK07486 1167634015694 Amidase; Region: Amidase; cl11426 1167634015695 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1167634015696 CoenzymeA binding site [chemical binding]; other site 1167634015697 subunit interaction site [polypeptide binding]; other site 1167634015698 PHB binding site; other site 1167634015699 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1167634015700 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1167634015701 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1167634015702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634015703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015704 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1167634015705 putative effector binding pocket; other site 1167634015706 putative dimerization interface [polypeptide binding]; other site 1167634015707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634015708 putative substrate translocation pore; other site 1167634015709 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1167634015710 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1167634015711 heme-binding site [chemical binding]; other site 1167634015712 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1167634015713 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1167634015714 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1167634015715 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1167634015716 AAA domain; Region: AAA_33; pfam13671 1167634015717 AAA domain; Region: AAA_17; pfam13207 1167634015718 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1167634015719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634015720 Coenzyme A binding pocket [chemical binding]; other site 1167634015721 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1167634015722 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1167634015723 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1167634015724 classical (c) SDRs; Region: SDR_c; cd05233 1167634015725 NAD(P) binding site [chemical binding]; other site 1167634015726 active site 1167634015727 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1167634015728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634015729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634015730 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1167634015731 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1167634015732 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1167634015733 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1167634015734 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1167634015735 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1167634015736 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1167634015737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634015738 DNA-binding site [nucleotide binding]; DNA binding site 1167634015739 UTRA domain; Region: UTRA; pfam07702 1167634015740 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1167634015741 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1167634015742 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1167634015743 nucleotide binding site [chemical binding]; other site 1167634015744 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1167634015745 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1167634015746 ligand binding site [chemical binding]; other site 1167634015747 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1167634015748 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1167634015749 Walker A/P-loop; other site 1167634015750 ATP binding site [chemical binding]; other site 1167634015751 Q-loop/lid; other site 1167634015752 ABC transporter signature motif; other site 1167634015753 Walker B; other site 1167634015754 D-loop; other site 1167634015755 H-loop/switch region; other site 1167634015756 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1167634015757 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634015758 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1167634015759 TM-ABC transporter signature motif; other site 1167634015760 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1167634015761 active site 1167634015762 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1167634015763 catalytic tetrad [active] 1167634015764 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1167634015765 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1167634015766 putative active site; other site 1167634015767 catalytic residue [active] 1167634015768 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1167634015769 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 1167634015770 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1167634015771 active site 1167634015772 substrate binding site [chemical binding]; other site 1167634015773 Mg2+ binding site [ion binding]; other site 1167634015774 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1167634015775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015776 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634015777 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1167634015778 putative substrate binding pocket [chemical binding]; other site 1167634015779 putative dimerization interface [polypeptide binding]; other site 1167634015780 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1167634015781 conserved cys residue [active] 1167634015782 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634015783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634015784 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1167634015785 active site residue [active] 1167634015786 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634015787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634015788 Coenzyme A binding pocket [chemical binding]; other site 1167634015789 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634015790 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1167634015791 argininosuccinate lyase; Provisional; Region: PRK00855 1167634015792 active sites [active] 1167634015793 tetramer interface [polypeptide binding]; other site 1167634015794 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1167634015795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015796 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1167634015797 putative dimerization interface [polypeptide binding]; other site 1167634015798 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1167634015799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634015800 putative substrate translocation pore; other site 1167634015801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015802 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634015803 putative effector binding pocket; other site 1167634015804 dimerization interface [polypeptide binding]; other site 1167634015805 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1167634015806 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1167634015807 DNA binding residues [nucleotide binding] 1167634015808 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1167634015809 HAMP domain; Region: HAMP; pfam00672 1167634015810 dimerization interface [polypeptide binding]; other site 1167634015811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634015812 dimer interface [polypeptide binding]; other site 1167634015813 phosphorylation site [posttranslational modification] 1167634015814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634015815 ATP binding site [chemical binding]; other site 1167634015816 Mg2+ binding site [ion binding]; other site 1167634015817 G-X-G motif; other site 1167634015818 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1167634015819 CoenzymeA binding site [chemical binding]; other site 1167634015820 subunit interaction site [polypeptide binding]; other site 1167634015821 PHB binding site; other site 1167634015822 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1167634015823 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1167634015824 FAD binding pocket [chemical binding]; other site 1167634015825 FAD binding motif [chemical binding]; other site 1167634015826 phosphate binding motif [ion binding]; other site 1167634015827 NAD binding pocket [chemical binding]; other site 1167634015828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634015829 S-adenosylmethionine binding site [chemical binding]; other site 1167634015830 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634015831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634015832 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1167634015833 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1167634015834 Transcriptional regulator; Region: Rrf2; pfam02082 1167634015835 short chain dehydrogenase; Provisional; Region: PRK06180 1167634015836 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1167634015837 NADP binding site [chemical binding]; other site 1167634015838 active site 1167634015839 steroid binding site; other site 1167634015840 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1167634015841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634015842 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634015843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1167634015844 Predicted kinase [General function prediction only]; Region: COG0645 1167634015845 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1167634015846 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1167634015847 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1167634015848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634015849 motif II; other site 1167634015850 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1167634015851 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634015852 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1167634015853 C-terminal domain interface [polypeptide binding]; other site 1167634015854 GSH binding site (G-site) [chemical binding]; other site 1167634015855 dimer interface [polypeptide binding]; other site 1167634015856 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1167634015857 N-terminal domain interface [polypeptide binding]; other site 1167634015858 dimer interface [polypeptide binding]; other site 1167634015859 substrate binding pocket (H-site) [chemical binding]; other site 1167634015860 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 1167634015861 putative hydrophobic ligand binding site [chemical binding]; other site 1167634015862 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634015863 dimerization interface [polypeptide binding]; other site 1167634015864 putative DNA binding site [nucleotide binding]; other site 1167634015865 putative Zn2+ binding site [ion binding]; other site 1167634015866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634015867 dimerization interface [polypeptide binding]; other site 1167634015868 putative DNA binding site [nucleotide binding]; other site 1167634015869 putative Zn2+ binding site [ion binding]; other site 1167634015870 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1167634015871 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1167634015872 putative NAD(P) binding site [chemical binding]; other site 1167634015873 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1167634015874 FAD binding site [chemical binding]; other site 1167634015875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634015876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015877 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1167634015878 putative dimerization interface [polypeptide binding]; other site 1167634015879 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 1167634015880 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1167634015881 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1167634015882 methionine synthase; Provisional; Region: PRK01207 1167634015883 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1167634015884 substrate binding site [chemical binding]; other site 1167634015885 THF binding site; other site 1167634015886 zinc-binding site [ion binding]; other site 1167634015887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015888 transcriptional activator TtdR; Provisional; Region: PRK09801 1167634015889 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634015890 putative effector binding pocket; other site 1167634015891 dimerization interface [polypeptide binding]; other site 1167634015892 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1167634015893 MULE transposase domain; Region: MULE; pfam10551 1167634015894 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1167634015895 Helix-turn-helix domain; Region: HTH_18; pfam12833 1167634015896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634015897 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1167634015898 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634015899 N-terminal plug; other site 1167634015900 ligand-binding site [chemical binding]; other site 1167634015901 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1167634015902 GMP synthase; Reviewed; Region: guaA; PRK00074 1167634015903 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1167634015904 AMP/PPi binding site [chemical binding]; other site 1167634015905 candidate oxyanion hole; other site 1167634015906 catalytic triad [active] 1167634015907 potential glutamine specificity residues [chemical binding]; other site 1167634015908 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1167634015909 ATP Binding subdomain [chemical binding]; other site 1167634015910 Ligand Binding sites [chemical binding]; other site 1167634015911 Dimerization subdomain; other site 1167634015912 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1167634015913 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1167634015914 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1167634015915 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1167634015916 active site 1167634015917 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 1167634015918 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1167634015919 YcxB-like protein; Region: YcxB; pfam14317 1167634015920 YcxB-like protein; Region: YcxB; pfam14317 1167634015921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015922 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1167634015923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634015924 dimerization interface [polypeptide binding]; other site 1167634015925 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634015926 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1167634015927 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1167634015928 putative ligand binding site [chemical binding]; other site 1167634015929 NAD binding site [chemical binding]; other site 1167634015930 catalytic site [active] 1167634015931 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634015932 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634015934 dimerization interface [polypeptide binding]; other site 1167634015935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634015936 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1167634015937 Amidase; Region: Amidase; pfam01425 1167634015938 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 1167634015939 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1167634015940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634015941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634015942 DNA binding residues [nucleotide binding] 1167634015943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 1167634015944 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1167634015945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634015946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634015947 dimerization interface [polypeptide binding]; other site 1167634015948 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1167634015949 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1167634015950 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634015951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634015952 dimer interface [polypeptide binding]; other site 1167634015953 conserved gate region; other site 1167634015954 putative PBP binding loops; other site 1167634015955 ABC-ATPase subunit interface; other site 1167634015956 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1167634015957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634015958 dimer interface [polypeptide binding]; other site 1167634015959 conserved gate region; other site 1167634015960 putative PBP binding loops; other site 1167634015961 ABC-ATPase subunit interface; other site 1167634015962 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1167634015963 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634015964 Walker A/P-loop; other site 1167634015965 ATP binding site [chemical binding]; other site 1167634015966 Q-loop/lid; other site 1167634015967 ABC transporter signature motif; other site 1167634015968 Walker B; other site 1167634015969 D-loop; other site 1167634015970 H-loop/switch region; other site 1167634015971 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634015972 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1167634015973 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634015974 Walker A/P-loop; other site 1167634015975 ATP binding site [chemical binding]; other site 1167634015976 Q-loop/lid; other site 1167634015977 ABC transporter signature motif; other site 1167634015978 Walker B; other site 1167634015979 D-loop; other site 1167634015980 H-loop/switch region; other site 1167634015981 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1167634015982 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1167634015983 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1167634015984 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 1167634015985 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1167634015986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1167634015987 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1167634015988 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1167634015989 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1167634015990 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1167634015991 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1167634015992 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634015993 N-terminal plug; other site 1167634015994 ligand-binding site [chemical binding]; other site 1167634015995 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1167634015996 B12 binding site [chemical binding]; other site 1167634015997 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1167634015998 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1167634015999 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634016000 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1167634016001 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634016002 Putative cyclase; Region: Cyclase; cl00814 1167634016003 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634016004 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634016005 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1167634016006 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634016007 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634016008 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634016009 dimerization interface [polypeptide binding]; other site 1167634016010 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1167634016011 Prephenate dehydratase; Region: PDT; pfam00800 1167634016012 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1167634016013 Family of unknown function (DUF695); Region: DUF695; pfam05117 1167634016014 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1167634016015 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1167634016016 phosphate binding site [ion binding]; other site 1167634016017 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634016018 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634016019 enoyl-CoA hydratase; Provisional; Region: PRK06495 1167634016020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634016021 substrate binding site [chemical binding]; other site 1167634016022 oxyanion hole (OAH) forming residues; other site 1167634016023 trimer interface [polypeptide binding]; other site 1167634016024 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634016025 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634016026 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634016027 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1167634016028 active site 1167634016029 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1167634016030 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634016031 active site 1167634016032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634016033 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634016034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634016035 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1167634016036 putative dimerization interface [polypeptide binding]; other site 1167634016037 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1167634016038 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634016039 active site 1167634016040 putative glutathione S-transferase; Provisional; Region: PRK10357 1167634016041 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1167634016042 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1167634016043 N-terminal domain interface [polypeptide binding]; other site 1167634016044 dimer interface [polypeptide binding]; other site 1167634016045 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1167634016046 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634016047 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634016048 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634016049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634016050 metal binding site [ion binding]; metal-binding site 1167634016051 active site 1167634016052 I-site; other site 1167634016053 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1167634016054 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634016055 N-terminal plug; other site 1167634016056 ligand-binding site [chemical binding]; other site 1167634016057 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1167634016058 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634016059 N-terminal plug; other site 1167634016060 ligand-binding site [chemical binding]; other site 1167634016061 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 1167634016062 NmrA-like family; Region: NmrA; pfam05368 1167634016063 NAD(P) binding site [chemical binding]; other site 1167634016064 active site lysine 1167634016065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634016066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634016067 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1167634016068 putative effector binding pocket; other site 1167634016069 putative dimerization interface [polypeptide binding]; other site 1167634016070 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 1167634016071 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1167634016072 active site 1167634016073 substrate binding site [chemical binding]; other site 1167634016074 Mg2+ binding site [ion binding]; other site 1167634016075 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1167634016076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634016077 NAD(P) binding site [chemical binding]; other site 1167634016078 active site 1167634016079 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1167634016080 EF-hand domain pair; Region: EF_hand_5; pfam13499 1167634016081 Ca2+ binding site [ion binding]; other site 1167634016082 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1167634016083 active site 1167634016084 ATP binding site [chemical binding]; other site 1167634016085 Phosphotransferase enzyme family; Region: APH; pfam01636 1167634016086 antibiotic binding site [chemical binding]; other site 1167634016087 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1167634016088 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1167634016089 putative active site [active] 1167634016090 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1167634016091 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634016092 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 1167634016093 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1167634016094 Na binding site [ion binding]; other site 1167634016095 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1167634016096 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1167634016097 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1167634016098 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1167634016099 classical (c) SDRs; Region: SDR_c; cd05233 1167634016100 NAD(P) binding site [chemical binding]; other site 1167634016101 active site 1167634016102 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1167634016103 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1167634016104 catalytic site [active] 1167634016105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634016106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634016107 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1167634016108 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1167634016109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634016110 putative substrate translocation pore; other site 1167634016111 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1167634016112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634016113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634016114 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1167634016115 putative effector binding pocket; other site 1167634016116 putative dimerization interface [polypeptide binding]; other site 1167634016117 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1167634016118 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1167634016119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634016120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634016121 dimer interface [polypeptide binding]; other site 1167634016122 phosphorylation site [posttranslational modification] 1167634016123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634016124 ATP binding site [chemical binding]; other site 1167634016125 Mg2+ binding site [ion binding]; other site 1167634016126 G-X-G motif; other site 1167634016127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634016128 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634016129 active site 1167634016130 phosphorylation site [posttranslational modification] 1167634016131 intermolecular recognition site; other site 1167634016132 dimerization interface [polypeptide binding]; other site 1167634016133 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634016134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634016135 active site 1167634016136 phosphorylation site [posttranslational modification] 1167634016137 intermolecular recognition site; other site 1167634016138 dimerization interface [polypeptide binding]; other site 1167634016139 Helix-turn-helix domain; Region: HTH_18; pfam12833 1167634016140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634016141 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1167634016142 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1167634016143 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1167634016144 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1167634016145 SapC; Region: SapC; pfam07277 1167634016146 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 1167634016147 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1167634016148 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634016149 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 1167634016150 camphor resistance protein CrcB; Provisional; Region: PRK14195 1167634016151 hypothetical protein; Provisional; Region: PRK07907 1167634016152 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 1167634016153 metal binding site [ion binding]; metal-binding site 1167634016154 putative dimer interface [polypeptide binding]; other site 1167634016155 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634016156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634016157 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634016158 dimerization interface [polypeptide binding]; other site 1167634016159 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-1; cd12808 1167634016160 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634016161 catalytic site [active] 1167634016162 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634016163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634016164 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1167634016165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634016166 dimer interface [polypeptide binding]; other site 1167634016167 phosphorylation site [posttranslational modification] 1167634016168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634016169 ATP binding site [chemical binding]; other site 1167634016170 Mg2+ binding site [ion binding]; other site 1167634016171 G-X-G motif; other site 1167634016172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634016173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634016174 active site 1167634016175 phosphorylation site [posttranslational modification] 1167634016176 intermolecular recognition site; other site 1167634016177 dimerization interface [polypeptide binding]; other site 1167634016178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634016179 DNA binding site [nucleotide binding] 1167634016180 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1167634016181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634016182 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634016183 putative effector binding pocket; other site 1167634016184 dimerization interface [polypeptide binding]; other site 1167634016185 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1167634016186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634016187 dimerization interface [polypeptide binding]; other site 1167634016188 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1167634016189 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634016190 dimer interface [polypeptide binding]; other site 1167634016191 putative CheW interface [polypeptide binding]; other site 1167634016192 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1167634016193 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634016194 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634016195 DNA binding residues [nucleotide binding] 1167634016196 fec operon regulator FecR; Reviewed; Region: PRK09774 1167634016197 FecR protein; Region: FecR; pfam04773 1167634016198 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1167634016199 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634016200 N-terminal plug; other site 1167634016201 ligand-binding site [chemical binding]; other site 1167634016202 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1167634016203 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1167634016204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1167634016205 dimerization interface [polypeptide binding]; other site 1167634016206 ATP binding site [chemical binding]; other site 1167634016207 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1167634016208 dimerization interface [polypeptide binding]; other site 1167634016209 ATP binding site [chemical binding]; other site 1167634016210 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1167634016211 putative active site [active] 1167634016212 catalytic triad [active] 1167634016213 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1167634016214 DctM-like transporters; Region: DctM; pfam06808 1167634016215 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1167634016216 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1167634016217 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1167634016218 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1167634016219 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1167634016220 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1167634016221 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1167634016222 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1167634016223 active site 1167634016224 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1167634016225 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1167634016226 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1167634016227 AAA domain; Region: AAA_17; cl17253 1167634016228 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1167634016229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634016230 S-adenosylmethionine binding site [chemical binding]; other site 1167634016231 choline dehydrogenase; Validated; Region: PRK02106 1167634016232 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1167634016233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634016234 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1167634016235 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634016236 dimerization interface [polypeptide binding]; other site 1167634016237 TonB C terminal; Region: TonB_2; pfam13103 1167634016238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634016239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634016240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634016241 dimerization interface [polypeptide binding]; other site 1167634016242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634016243 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634016244 putative substrate translocation pore; other site 1167634016245 acetylornithine deacetylase; Provisional; Region: PRK06837 1167634016246 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1167634016247 metal binding site [ion binding]; metal-binding site 1167634016248 dimer interface [polypeptide binding]; other site 1167634016249 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1167634016250 Competence protein; Region: Competence; pfam03772 1167634016251 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1167634016252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1167634016253 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1167634016254 substrate binding site [chemical binding]; other site 1167634016255 active site 1167634016256 catalytic residues [active] 1167634016257 heterodimer interface [polypeptide binding]; other site 1167634016258 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1167634016259 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1167634016260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634016261 catalytic residue [active] 1167634016262 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1167634016263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634016264 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634016265 dimerization interface [polypeptide binding]; other site 1167634016266 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1167634016267 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1167634016268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634016269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634016270 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1167634016271 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1167634016272 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1167634016273 oligomerisation interface [polypeptide binding]; other site 1167634016274 mobile loop; other site 1167634016275 roof hairpin; other site 1167634016276 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1167634016277 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1167634016278 ring oligomerisation interface [polypeptide binding]; other site 1167634016279 ATP/Mg binding site [chemical binding]; other site 1167634016280 stacking interactions; other site 1167634016281 hinge regions; other site 1167634016282 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1167634016283 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1167634016284 putative dimer interface [polypeptide binding]; other site 1167634016285 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1167634016286 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1167634016287 putative dimer interface [polypeptide binding]; other site 1167634016288 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1167634016289 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1167634016290 MoxR-like ATPases [General function prediction only]; Region: COG0714 1167634016291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634016292 Walker A motif; other site 1167634016293 ATP binding site [chemical binding]; other site 1167634016294 Walker B motif; other site 1167634016295 arginine finger; other site 1167634016296 Protein of unknown function DUF58; Region: DUF58; pfam01882 1167634016297 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1167634016298 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1167634016299 metal ion-dependent adhesion site (MIDAS); other site 1167634016300 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1167634016301 metal ion-dependent adhesion site (MIDAS); other site 1167634016302 Oxygen tolerance; Region: BatD; pfam13584 1167634016303 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1167634016304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634016305 motif II; other site 1167634016306 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1167634016307 Sulfatase; Region: Sulfatase; pfam00884 1167634016308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1167634016309 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634016310 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1167634016311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634016312 S-adenosylmethionine binding site [chemical binding]; other site 1167634016313 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1167634016314 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1167634016315 catalytic loop [active] 1167634016316 iron binding site [ion binding]; other site 1167634016317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634016318 NAD(P) binding site [chemical binding]; other site 1167634016319 active site 1167634016320 short chain dehydrogenase; Provisional; Region: PRK06123 1167634016321 classical (c) SDRs; Region: SDR_c; cd05233 1167634016322 NAD(P) binding site [chemical binding]; other site 1167634016323 active site 1167634016324 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1167634016325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634016326 Walker A/P-loop; other site 1167634016327 ATP binding site [chemical binding]; other site 1167634016328 Q-loop/lid; other site 1167634016329 ABC transporter signature motif; other site 1167634016330 Walker B; other site 1167634016331 D-loop; other site 1167634016332 H-loop/switch region; other site 1167634016333 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1167634016334 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1167634016335 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634016336 dimer interface [polypeptide binding]; other site 1167634016337 putative metal binding site [ion binding]; other site 1167634016338 MarR family; Region: MarR_2; cl17246 1167634016339 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1167634016340 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1167634016341 substrate binding site [chemical binding]; other site 1167634016342 multimerization interface [polypeptide binding]; other site 1167634016343 ATP binding site [chemical binding]; other site 1167634016344 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1167634016345 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634016346 N-terminal plug; other site 1167634016347 ligand-binding site [chemical binding]; other site 1167634016348 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1167634016349 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1167634016350 active site 1167634016351 metal binding site [ion binding]; metal-binding site 1167634016352 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1167634016353 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1167634016354 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1167634016355 Walker A/P-loop; other site 1167634016356 ATP binding site [chemical binding]; other site 1167634016357 Q-loop/lid; other site 1167634016358 ABC transporter signature motif; other site 1167634016359 Walker B; other site 1167634016360 D-loop; other site 1167634016361 H-loop/switch region; other site 1167634016362 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1167634016363 ABC-ATPase subunit interface; other site 1167634016364 dimer interface [polypeptide binding]; other site 1167634016365 putative PBP binding regions; other site 1167634016366 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1167634016367 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1167634016368 ABC-ATPase subunit interface; other site 1167634016369 dimer interface [polypeptide binding]; other site 1167634016370 putative PBP binding regions; other site 1167634016371 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1167634016372 putative ligand binding residues [chemical binding]; other site 1167634016373 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1167634016374 enterobactin receptor protein; Provisional; Region: PRK13483 1167634016375 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634016376 N-terminal plug; other site 1167634016377 ligand-binding site [chemical binding]; other site 1167634016378 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634016379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634016380 active site 1167634016381 phosphorylation site [posttranslational modification] 1167634016382 intermolecular recognition site; other site 1167634016383 dimerization interface [polypeptide binding]; other site 1167634016384 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634016385 DNA binding site [nucleotide binding] 1167634016386 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1167634016387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634016388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634016389 dimer interface [polypeptide binding]; other site 1167634016390 phosphorylation site [posttranslational modification] 1167634016391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634016392 ATP binding site [chemical binding]; other site 1167634016393 Mg2+ binding site [ion binding]; other site 1167634016394 G-X-G motif; other site 1167634016395 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1167634016396 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1167634016397 active site 1167634016398 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1167634016399 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1167634016400 Walker A/P-loop; other site 1167634016401 ATP binding site [chemical binding]; other site 1167634016402 Q-loop/lid; other site 1167634016403 ABC transporter signature motif; other site 1167634016404 Walker B; other site 1167634016405 D-loop; other site 1167634016406 H-loop/switch region; other site 1167634016407 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1167634016408 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1167634016409 FtsX-like permease family; Region: FtsX; pfam02687 1167634016410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 1167634016411 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1167634016412 DHH family; Region: DHH; pfam01368 1167634016413 DHHA1 domain; Region: DHHA1; pfam02272 1167634016414 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1167634016415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634016416 putative substrate translocation pore; other site 1167634016417 peptide chain release factor 2; Provisional; Region: PRK08787 1167634016418 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1167634016419 RF-1 domain; Region: RF-1; pfam00472 1167634016420 short chain dehydrogenase; Provisional; Region: PRK07023 1167634016421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634016422 NAD(P) binding site [chemical binding]; other site 1167634016423 active site 1167634016424 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1167634016425 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1167634016426 dimer interface [polypeptide binding]; other site 1167634016427 putative anticodon binding site; other site 1167634016428 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1167634016429 motif 1; other site 1167634016430 active site 1167634016431 motif 2; other site 1167634016432 motif 3; other site 1167634016433 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634016434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634016435 DNA-binding site [nucleotide binding]; DNA binding site 1167634016436 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634016437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634016438 homodimer interface [polypeptide binding]; other site 1167634016439 catalytic residue [active] 1167634016440 benzoate transporter; Region: benE; TIGR00843 1167634016441 Benzoate membrane transport protein; Region: BenE; pfam03594 1167634016442 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1167634016443 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1167634016444 catalytic residue [active] 1167634016445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634016446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634016447 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 1167634016448 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1167634016449 dimer interface [polypeptide binding]; other site 1167634016450 active site 1167634016451 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634016452 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1167634016453 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634016454 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1167634016455 acyl-activating enzyme (AAE) consensus motif; other site 1167634016456 putative AMP binding site [chemical binding]; other site 1167634016457 putative active site [active] 1167634016458 putative CoA binding site [chemical binding]; other site 1167634016459 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634016460 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634016461 Walker A/P-loop; other site 1167634016462 ATP binding site [chemical binding]; other site 1167634016463 Q-loop/lid; other site 1167634016464 ABC transporter signature motif; other site 1167634016465 Walker B; other site 1167634016466 D-loop; other site 1167634016467 H-loop/switch region; other site 1167634016468 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1167634016469 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634016470 putative ligand binding site [chemical binding]; other site 1167634016471 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634016472 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634016473 TM-ABC transporter signature motif; other site 1167634016474 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634016475 TM-ABC transporter signature motif; other site 1167634016476 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634016477 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634016478 Walker A/P-loop; other site 1167634016479 ATP binding site [chemical binding]; other site 1167634016480 Q-loop/lid; other site 1167634016481 ABC transporter signature motif; other site 1167634016482 Walker B; other site 1167634016483 D-loop; other site 1167634016484 H-loop/switch region; other site 1167634016485 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1167634016486 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634016487 substrate binding site [chemical binding]; other site 1167634016488 oxyanion hole (OAH) forming residues; other site 1167634016489 trimer interface [polypeptide binding]; other site 1167634016490 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1167634016491 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634016492 N-terminal plug; other site 1167634016493 ligand-binding site [chemical binding]; other site 1167634016494 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1167634016495 active site 1167634016496 dimer interfaces [polypeptide binding]; other site 1167634016497 catalytic residues [active] 1167634016498 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 1167634016499 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1167634016500 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1167634016501 catalytic loop [active] 1167634016502 iron binding site [ion binding]; other site 1167634016503 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1167634016504 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1167634016505 nucleotide binding site [chemical binding]; other site 1167634016506 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1167634016507 SBD interface [polypeptide binding]; other site 1167634016508 co-chaperone HscB; Provisional; Region: hscB; PRK03578 1167634016509 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1167634016510 HSP70 interaction site [polypeptide binding]; other site 1167634016511 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1167634016512 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1167634016513 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1167634016514 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1167634016515 trimerization site [polypeptide binding]; other site 1167634016516 active site 1167634016517 cysteine desulfurase; Provisional; Region: PRK14012 1167634016518 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1167634016519 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634016520 catalytic residue [active] 1167634016521 Transcriptional regulator; Region: Rrf2; cl17282 1167634016522 Predicted transcriptional regulator [Transcription]; Region: COG1959 1167634016523 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1167634016524 excinuclease ABC subunit B; Provisional; Region: PRK05298 1167634016525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1167634016526 ATP binding site [chemical binding]; other site 1167634016527 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1167634016528 nucleotide binding region [chemical binding]; other site 1167634016529 ATP-binding site [chemical binding]; other site 1167634016530 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1167634016531 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1167634016532 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634016533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634016534 homodimer interface [polypeptide binding]; other site 1167634016535 catalytic residue [active] 1167634016536 LexA repressor; Validated; Region: PRK00215 1167634016537 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1167634016538 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1167634016539 Catalytic site [active] 1167634016540 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1167634016541 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1167634016542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634016543 Walker A motif; other site 1167634016544 ATP binding site [chemical binding]; other site 1167634016545 Walker B motif; other site 1167634016546 arginine finger; other site 1167634016547 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1167634016548 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1167634016549 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1167634016550 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1167634016551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634016552 Walker A motif; other site 1167634016553 ATP binding site [chemical binding]; other site 1167634016554 Walker B motif; other site 1167634016555 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1167634016556 Clp protease; Region: CLP_protease; pfam00574 1167634016557 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1167634016558 oligomer interface [polypeptide binding]; other site 1167634016559 active site residues [active] 1167634016560 trigger factor; Provisional; Region: tig; PRK01490 1167634016561 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1167634016562 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1167634016563 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1167634016564 hypothetical protein; Provisional; Region: PRK05208 1167634016565 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1167634016566 DNA-binding site [nucleotide binding]; DNA binding site 1167634016567 RNA-binding motif; other site 1167634016568 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1167634016569 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1167634016570 DNA-binding site [nucleotide binding]; DNA binding site 1167634016571 RNA-binding motif; other site 1167634016572 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1167634016573 homotrimer interaction site [polypeptide binding]; other site 1167634016574 putative active site [active] 1167634016575 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 1167634016576 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1167634016577 active site 1167634016578 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1167634016579 dimer interface [polypeptide binding]; other site 1167634016580 substrate binding site [chemical binding]; other site 1167634016581 catalytic residue [active] 1167634016582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634016583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634016584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634016585 dimerization interface [polypeptide binding]; other site 1167634016586 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1167634016587 homotrimer interaction site [polypeptide binding]; other site 1167634016588 putative active site [active] 1167634016589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634016590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634016591 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1167634016592 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 1167634016593 HD domain; Region: HD_3; pfam13023 1167634016594 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1167634016595 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1167634016596 aquaporin Z; Provisional; Region: PRK05420 1167634016597 amphipathic channel; other site 1167634016598 Asn-Pro-Ala signature motifs; other site 1167634016599 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1167634016600 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1167634016601 FAD binding domain; Region: FAD_binding_4; pfam01565 1167634016602 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1167634016603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1167634016604 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1167634016605 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1167634016606 nucleotide binding site [chemical binding]; other site 1167634016607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634016608 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634016609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634016610 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1167634016611 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1167634016612 Phage-related protein, tail component [Function unknown]; Region: COG4733 1167634016613 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1167634016614 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1167634016615 Interdomain contacts; other site 1167634016616 Cytokine receptor motif; other site 1167634016617 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1167634016618 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1167634016619 MPN+ (JAMM) motif; other site 1167634016620 Zinc-binding site [ion binding]; other site 1167634016621 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1167634016622 NlpC/P60 family; Region: NLPC_P60; cl17555 1167634016623 Phage minor tail protein L; Region: Phage_tail_L; cl01908 1167634016624 Bacteriophage T4 gp9/10-like protein; Region: T4_gp9_10; cl17844 1167634016625 Phage minor tail protein; Region: Phage_min_tail; pfam05939 1167634016626 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1167634016627 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 1167634016628 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1167634016629 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1167634016630 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1167634016631 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1167634016632 oligomer interface [polypeptide binding]; other site 1167634016633 Clp protease; Region: CLP_protease; pfam00574 1167634016634 active site residues [active] 1167634016635 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1167634016636 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 1167634016637 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1167634016638 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 1167634016639 KilA-N domain; Region: KilA-N; pfam04383 1167634016640 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1167634016641 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 1167634016642 RNA polymerase sigma factor; Validated; Region: PRK05949 1167634016643 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1167634016644 active site 1167634016645 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1167634016646 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1167634016647 dimer interface [polypeptide binding]; other site 1167634016648 ssDNA binding site [nucleotide binding]; other site 1167634016649 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1167634016650 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1167634016651 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 1167634016652 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1167634016653 Protein of unknown function (DUF550); Region: DUF550; pfam04447 1167634016654 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1167634016655 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634016656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634016657 homodimer interface [polypeptide binding]; other site 1167634016658 catalytic residue [active] 1167634016659 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1167634016660 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1167634016661 trimer interface [polypeptide binding]; other site 1167634016662 active site 1167634016663 substrate binding site [chemical binding]; other site 1167634016664 CoA binding site [chemical binding]; other site 1167634016665 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1167634016666 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1167634016667 metal binding site [ion binding]; metal-binding site 1167634016668 dimer interface [polypeptide binding]; other site 1167634016669 HemK family putative methylases; Region: hemK_fam; TIGR00536 1167634016670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634016671 S-adenosylmethionine binding site [chemical binding]; other site 1167634016672 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1167634016673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634016674 Walker A/P-loop; other site 1167634016675 ATP binding site [chemical binding]; other site 1167634016676 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634016677 ABC transporter; Region: ABC_tran_2; pfam12848 1167634016678 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1167634016679 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1167634016680 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634016681 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1167634016682 DNA binding residues [nucleotide binding] 1167634016683 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634016684 FecR protein; Region: FecR; pfam04773 1167634016685 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1167634016686 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1167634016687 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634016688 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1167634016689 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1167634016690 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634016691 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1167634016692 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1167634016693 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1167634016694 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1167634016695 Chorismate mutase type II; Region: CM_2; cl00693 1167634016696 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1167634016697 Part of AAA domain; Region: AAA_19; pfam13245 1167634016698 Family description; Region: UvrD_C_2; pfam13538 1167634016699 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1167634016700 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1167634016701 Di-iron ligands [ion binding]; other site 1167634016702 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1167634016703 16S rRNA methyltransferase B; Provisional; Region: PRK14901 1167634016704 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1167634016705 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1167634016706 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1167634016707 active site 1167634016708 substrate binding site [chemical binding]; other site 1167634016709 cosubstrate binding site; other site 1167634016710 catalytic site [active] 1167634016711 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1167634016712 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1167634016713 Riboflavin kinase; Region: Flavokinase; smart00904 1167634016714 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1167634016715 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1167634016716 active site 1167634016717 HIGH motif; other site 1167634016718 nucleotide binding site [chemical binding]; other site 1167634016719 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1167634016720 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1167634016721 active site 1167634016722 KMSKS motif; other site 1167634016723 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1167634016724 tRNA binding surface [nucleotide binding]; other site 1167634016725 anticodon binding site; other site 1167634016726 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1167634016727 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1167634016728 lipoprotein signal peptidase; Provisional; Region: PRK14787 1167634016729 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1167634016730 Flavoprotein; Region: Flavoprotein; pfam02441 1167634016731 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1167634016732 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634016733 AroM protein; Region: AroM; cl17601 1167634016734 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 1167634016735 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1167634016736 active site pocket [active] 1167634016737 oxyanion hole [active] 1167634016738 catalytic triad [active] 1167634016739 active site nucleophile [active] 1167634016740 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634016741 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1167634016742 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634016743 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1167634016744 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1167634016745 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1167634016746 dUTPase; Region: dUTPase_2; pfam08761 1167634016747 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1167634016748 active site 1167634016749 homodimer interface [polypeptide binding]; other site 1167634016750 metal binding site [ion binding]; metal-binding site 1167634016751 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1167634016752 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1167634016753 active site 1167634016754 FMN binding site [chemical binding]; other site 1167634016755 substrate binding site [chemical binding]; other site 1167634016756 homotetramer interface [polypeptide binding]; other site 1167634016757 catalytic residue [active] 1167634016758 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634016759 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634016760 Walker A/P-loop; other site 1167634016761 ATP binding site [chemical binding]; other site 1167634016762 Q-loop/lid; other site 1167634016763 ABC transporter signature motif; other site 1167634016764 Walker B; other site 1167634016765 D-loop; other site 1167634016766 H-loop/switch region; other site 1167634016767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634016768 dimer interface [polypeptide binding]; other site 1167634016769 conserved gate region; other site 1167634016770 putative PBP binding loops; other site 1167634016771 ABC-ATPase subunit interface; other site 1167634016772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634016773 dimer interface [polypeptide binding]; other site 1167634016774 conserved gate region; other site 1167634016775 putative PBP binding loops; other site 1167634016776 ABC-ATPase subunit interface; other site 1167634016777 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 1167634016778 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634016779 substrate binding pocket [chemical binding]; other site 1167634016780 membrane-bound complex binding site; other site 1167634016781 hinge residues; other site 1167634016782 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1167634016783 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1167634016784 putative ligand binding site [chemical binding]; other site 1167634016785 ornithine cyclodeaminase; Validated; Region: PRK06141 1167634016786 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1167634016787 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1167634016788 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1167634016789 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1167634016790 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1167634016791 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1167634016792 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634016793 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1167634016794 C-terminal domain interface [polypeptide binding]; other site 1167634016795 GSH binding site (G-site) [chemical binding]; other site 1167634016796 dimer interface [polypeptide binding]; other site 1167634016797 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1167634016798 dimer interface [polypeptide binding]; other site 1167634016799 N-terminal domain interface [polypeptide binding]; other site 1167634016800 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1167634016801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634016802 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1167634016803 dimerization interface [polypeptide binding]; other site 1167634016804 substrate binding pocket [chemical binding]; other site 1167634016805 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1167634016806 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1167634016807 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1167634016808 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634016809 N-terminal plug; other site 1167634016810 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1167634016811 ligand-binding site [chemical binding]; other site 1167634016812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634016813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634016814 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634016815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634016816 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634016817 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634016818 Walker A/P-loop; other site 1167634016819 ATP binding site [chemical binding]; other site 1167634016820 Q-loop/lid; other site 1167634016821 ABC transporter signature motif; other site 1167634016822 Walker B; other site 1167634016823 D-loop; other site 1167634016824 H-loop/switch region; other site 1167634016825 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634016826 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634016827 Walker A/P-loop; other site 1167634016828 ATP binding site [chemical binding]; other site 1167634016829 Q-loop/lid; other site 1167634016830 ABC transporter signature motif; other site 1167634016831 Walker B; other site 1167634016832 D-loop; other site 1167634016833 H-loop/switch region; other site 1167634016834 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634016835 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634016836 TM-ABC transporter signature motif; other site 1167634016837 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634016838 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634016839 TM-ABC transporter signature motif; other site 1167634016840 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1167634016841 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1167634016842 dimerization interface [polypeptide binding]; other site 1167634016843 ligand binding site [chemical binding]; other site 1167634016844 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1167634016845 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1167634016846 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1167634016847 Glutamate binding site [chemical binding]; other site 1167634016848 NAD binding site [chemical binding]; other site 1167634016849 catalytic residues [active] 1167634016850 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1167634016851 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1167634016852 mce related protein; Region: MCE; pfam02470 1167634016853 mce related protein; Region: MCE; pfam02470 1167634016854 mce related protein; Region: MCE; pfam02470 1167634016855 Paraquat-inducible protein A; Region: PqiA; pfam04403 1167634016856 Paraquat-inducible protein A; Region: PqiA; pfam04403 1167634016857 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1167634016858 Clp amino terminal domain; Region: Clp_N; pfam02861 1167634016859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634016860 Walker A motif; other site 1167634016861 ATP binding site [chemical binding]; other site 1167634016862 Walker B motif; other site 1167634016863 arginine finger; other site 1167634016864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634016865 Walker A motif; other site 1167634016866 ATP binding site [chemical binding]; other site 1167634016867 Walker B motif; other site 1167634016868 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1167634016869 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 1167634016870 Transglycosylase; Region: Transgly; pfam00912 1167634016871 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1167634016872 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1167634016873 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1167634016874 MG2 domain; Region: A2M_N; pfam01835 1167634016875 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1167634016876 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1167634016877 surface patch; other site 1167634016878 thioester region; other site 1167634016879 specificity defining residues; other site 1167634016880 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1167634016881 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1167634016882 DNA-binding site [nucleotide binding]; DNA binding site 1167634016883 RNA-binding motif; other site 1167634016884 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1167634016885 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1167634016886 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1167634016887 dimer interface [polypeptide binding]; other site 1167634016888 active site 1167634016889 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1167634016890 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 1167634016891 putative ion selectivity filter; other site 1167634016892 putative pore gating glutamate residue; other site 1167634016893 putative H+/Cl- coupling transport residue; other site 1167634016894 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1167634016895 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634016896 dimerization interface [polypeptide binding]; other site 1167634016897 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1167634016898 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634016899 dimer interface [polypeptide binding]; other site 1167634016900 putative CheW interface [polypeptide binding]; other site 1167634016901 superoxide dismutase; Provisional; Region: PRK10543 1167634016902 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1167634016903 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1167634016904 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1167634016905 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1167634016906 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1167634016907 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1167634016908 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1167634016909 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1167634016910 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1167634016911 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1167634016912 generic binding surface II; other site 1167634016913 generic binding surface I; other site 1167634016914 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1167634016915 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1167634016916 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1167634016917 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 1167634016918 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1167634016919 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1167634016920 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1167634016921 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1167634016922 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1167634016923 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1167634016924 Ligand binding site; other site 1167634016925 oligomer interface; other site 1167634016926 adenylate kinase; Reviewed; Region: adk; PRK00279 1167634016927 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1167634016928 AMP-binding site [chemical binding]; other site 1167634016929 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1167634016930 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1167634016931 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1167634016932 NAD binding site [chemical binding]; other site 1167634016933 homodimer interface [polypeptide binding]; other site 1167634016934 homotetramer interface [polypeptide binding]; other site 1167634016935 active site 1167634016936 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1167634016937 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1167634016938 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634016939 FecR protein; Region: FecR; pfam04773 1167634016940 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1167634016941 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1167634016942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634016943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634016944 dimerization interface [polypeptide binding]; other site 1167634016945 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1167634016946 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1167634016947 active site 1167634016948 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1167634016949 substrate binding site [chemical binding]; other site 1167634016950 catalytic residues [active] 1167634016951 dimer interface [polypeptide binding]; other site 1167634016952 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1167634016953 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634016954 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1167634016955 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1167634016956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634016957 DNA-binding site [nucleotide binding]; DNA binding site 1167634016958 FCD domain; Region: FCD; pfam07729 1167634016959 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1167634016960 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1167634016961 inhibitor site; inhibition site 1167634016962 active site 1167634016963 dimer interface [polypeptide binding]; other site 1167634016964 catalytic residue [active] 1167634016965 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634016966 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634016967 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1167634016968 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1167634016969 putative ligand binding site [chemical binding]; other site 1167634016970 NAD binding site [chemical binding]; other site 1167634016971 catalytic site [active] 1167634016972 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1167634016973 DNA repair protein RadA; Provisional; Region: PRK11823 1167634016974 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1167634016975 Walker A motif/ATP binding site; other site 1167634016976 ATP binding site [chemical binding]; other site 1167634016977 Walker B motif; other site 1167634016978 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1167634016979 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1167634016980 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1167634016981 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1167634016982 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1167634016983 putative active site [active] 1167634016984 putative metal binding site [ion binding]; other site 1167634016985 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1167634016986 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1167634016987 NAD binding site [chemical binding]; other site 1167634016988 catalytic residues [active] 1167634016989 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1167634016990 putative substrate binding pocket [chemical binding]; other site 1167634016991 trimer interface [polypeptide binding]; other site 1167634016992 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1167634016993 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1167634016994 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1167634016995 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1167634016996 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1167634016997 short chain dehydrogenase; Provisional; Region: PRK07577 1167634016998 classical (c) SDRs; Region: SDR_c; cd05233 1167634016999 NAD(P) binding site [chemical binding]; other site 1167634017000 active site 1167634017001 alanine racemase; Reviewed; Region: dadX; PRK03646 1167634017002 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1167634017003 active site 1167634017004 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1167634017005 substrate binding site [chemical binding]; other site 1167634017006 catalytic residues [active] 1167634017007 dimer interface [polypeptide binding]; other site 1167634017008 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1167634017009 active site lid residues [active] 1167634017010 substrate binding pocket [chemical binding]; other site 1167634017011 catalytic residues [active] 1167634017012 substrate-Mg2+ binding site; other site 1167634017013 aspartate-rich region 1; other site 1167634017014 aspartate-rich region 2; other site 1167634017015 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1167634017016 active site lid residues [active] 1167634017017 substrate binding pocket [chemical binding]; other site 1167634017018 catalytic residues [active] 1167634017019 substrate-Mg2+ binding site; other site 1167634017020 aspartate-rich region 1; other site 1167634017021 aspartate-rich region 2; other site 1167634017022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1167634017023 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1167634017024 chromosome condensation membrane protein; Provisional; Region: PRK14196 1167634017025 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1167634017026 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017027 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1167634017028 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1167634017029 active site 1167634017030 putative substrate binding pocket [chemical binding]; other site 1167634017031 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634017032 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634017033 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634017034 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1167634017035 putative dimerization interface [polypeptide binding]; other site 1167634017036 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1167634017037 putative hydrophobic ligand binding site [chemical binding]; other site 1167634017038 protein interface [polypeptide binding]; other site 1167634017039 gate; other site 1167634017040 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 1167634017041 hypothetical protein; Provisional; Region: PRK02399 1167634017042 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1167634017043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634017044 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1167634017045 DNA-binding interface [nucleotide binding]; DNA binding site 1167634017046 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1167634017047 active site 1167634017048 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1167634017049 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1167634017050 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1167634017051 Clp amino terminal domain; Region: Clp_N; pfam02861 1167634017052 Clp amino terminal domain; Region: Clp_N; pfam02861 1167634017053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634017054 Walker A motif; other site 1167634017055 ATP binding site [chemical binding]; other site 1167634017056 Walker B motif; other site 1167634017057 arginine finger; other site 1167634017058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634017059 Walker A motif; other site 1167634017060 ATP binding site [chemical binding]; other site 1167634017061 Walker B motif; other site 1167634017062 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1167634017063 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1167634017064 putative active site pocket [active] 1167634017065 putative catalytic residue [active] 1167634017066 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1167634017067 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1167634017068 ligand binding site [chemical binding]; other site 1167634017069 flexible hinge region; other site 1167634017070 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1167634017071 putative switch regulator; other site 1167634017072 non-specific DNA interactions [nucleotide binding]; other site 1167634017073 DNA binding site [nucleotide binding] 1167634017074 sequence specific DNA binding site [nucleotide binding]; other site 1167634017075 putative cAMP binding site [chemical binding]; other site 1167634017076 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1167634017077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634017078 putative substrate translocation pore; other site 1167634017079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634017080 dimerization interface [polypeptide binding]; other site 1167634017081 putative DNA binding site [nucleotide binding]; other site 1167634017082 putative Zn2+ binding site [ion binding]; other site 1167634017083 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1167634017084 putative hydrophobic ligand binding site [chemical binding]; other site 1167634017085 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1167634017086 catalytic loop [active] 1167634017087 iron binding site [ion binding]; other site 1167634017088 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1167634017089 dimer interface [polypeptide binding]; other site 1167634017090 ADP-ribose binding site [chemical binding]; other site 1167634017091 active site 1167634017092 nudix motif; other site 1167634017093 metal binding site [ion binding]; metal-binding site 1167634017094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634017095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634017096 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1167634017097 putative effector binding pocket; other site 1167634017098 putative dimerization interface [polypeptide binding]; other site 1167634017099 putative chaperone; Provisional; Region: PRK11678 1167634017100 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1167634017101 nucleotide binding site [chemical binding]; other site 1167634017102 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1167634017103 SBD interface [polypeptide binding]; other site 1167634017104 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1167634017105 muropeptide transporter; Validated; Region: ampG; cl17669 1167634017106 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1167634017107 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634017108 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634017109 N-terminal plug; other site 1167634017110 ligand-binding site [chemical binding]; other site 1167634017111 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1167634017112 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634017113 N-terminal plug; other site 1167634017114 ligand-binding site [chemical binding]; other site 1167634017115 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634017116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634017117 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1167634017118 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1167634017119 conserved cys residue [active] 1167634017120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634017121 putative substrate translocation pore; other site 1167634017122 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1167634017123 Isochorismatase family; Region: Isochorismatase; pfam00857 1167634017124 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1167634017125 catalytic triad [active] 1167634017126 conserved cis-peptide bond; other site 1167634017127 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1167634017128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634017129 Coenzyme A binding pocket [chemical binding]; other site 1167634017130 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634017131 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1167634017132 putative C-terminal domain interface [polypeptide binding]; other site 1167634017133 putative GSH binding site (G-site) [chemical binding]; other site 1167634017134 putative dimer interface [polypeptide binding]; other site 1167634017135 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1167634017136 putative dimer interface [polypeptide binding]; other site 1167634017137 putative N-terminal domain interface [polypeptide binding]; other site 1167634017138 putative substrate binding pocket (H-site) [chemical binding]; other site 1167634017139 OsmC-like protein; Region: OsmC; cl00767 1167634017140 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1167634017141 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634017142 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1167634017143 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634017144 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017145 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634017146 active site 1167634017147 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017148 hypothetical protein; Validated; Region: PRK06201 1167634017149 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1167634017150 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1167634017151 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1167634017152 ligand binding site [chemical binding]; other site 1167634017153 NAD binding site [chemical binding]; other site 1167634017154 dimerization interface [polypeptide binding]; other site 1167634017155 catalytic site [active] 1167634017156 Putative cyclase; Region: Cyclase; cl00814 1167634017157 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017158 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017159 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1167634017160 Strictosidine synthase; Region: Str_synth; pfam03088 1167634017161 NlpE N-terminal domain; Region: NlpE; pfam04170 1167634017162 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1167634017163 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634017164 substrate binding pocket [chemical binding]; other site 1167634017165 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 1167634017166 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1167634017167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634017168 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1167634017169 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1167634017170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634017171 catalytic residue [active] 1167634017172 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634017173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634017174 putative DNA binding site [nucleotide binding]; other site 1167634017175 putative Zn2+ binding site [ion binding]; other site 1167634017176 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634017177 MarR family; Region: MarR_2; cl17246 1167634017178 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1167634017179 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634017180 Walker A/P-loop; other site 1167634017181 ATP binding site [chemical binding]; other site 1167634017182 Q-loop/lid; other site 1167634017183 ABC transporter signature motif; other site 1167634017184 Walker B; other site 1167634017185 D-loop; other site 1167634017186 H-loop/switch region; other site 1167634017187 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1167634017188 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634017189 Walker A/P-loop; other site 1167634017190 ATP binding site [chemical binding]; other site 1167634017191 Q-loop/lid; other site 1167634017192 ABC transporter signature motif; other site 1167634017193 Walker B; other site 1167634017194 D-loop; other site 1167634017195 H-loop/switch region; other site 1167634017196 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634017197 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1167634017198 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1167634017199 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634017200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634017201 dimer interface [polypeptide binding]; other site 1167634017202 conserved gate region; other site 1167634017203 putative PBP binding loops; other site 1167634017204 ABC-ATPase subunit interface; other site 1167634017205 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1167634017206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634017207 dimer interface [polypeptide binding]; other site 1167634017208 conserved gate region; other site 1167634017209 putative PBP binding loops; other site 1167634017210 ABC-ATPase subunit interface; other site 1167634017211 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_5; cd06232 1167634017212 putative active site [active] 1167634017213 Zn binding site [ion binding]; other site 1167634017214 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1167634017215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634017216 Coenzyme A binding pocket [chemical binding]; other site 1167634017217 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1167634017218 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1167634017219 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634017220 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1167634017221 fec operon regulator FecR; Reviewed; Region: PRK09774 1167634017222 FecR protein; Region: FecR; pfam04773 1167634017223 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634017224 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634017225 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634017226 N-terminal plug; other site 1167634017227 ligand-binding site [chemical binding]; other site 1167634017228 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 1167634017229 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1167634017230 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1167634017231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634017232 S-adenosylmethionine binding site [chemical binding]; other site 1167634017233 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1167634017234 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1167634017235 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1167634017236 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1167634017237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634017238 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1167634017239 dimerization interface [polypeptide binding]; other site 1167634017240 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1167634017241 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1167634017242 active site 1167634017243 purine riboside binding site [chemical binding]; other site 1167634017244 Carboxylesterase family; Region: COesterase; pfam00135 1167634017245 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1167634017246 substrate binding pocket [chemical binding]; other site 1167634017247 catalytic triad [active] 1167634017248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634017249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634017250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634017251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634017252 putative substrate translocation pore; other site 1167634017253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634017254 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 1167634017255 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1167634017256 metal binding site [ion binding]; metal-binding site 1167634017257 putative dimer interface [polypeptide binding]; other site 1167634017258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634017259 Coenzyme A binding pocket [chemical binding]; other site 1167634017260 putative L-aspartate dehydrogenase; Provisional; Region: PRK13302 1167634017261 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1167634017262 Domain of unknown function DUF108; Region: DUF108; pfam01958 1167634017263 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1167634017264 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1167634017265 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1167634017266 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634017267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634017268 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1167634017269 dimerization interface [polypeptide binding]; other site 1167634017270 substrate binding pocket [chemical binding]; other site 1167634017271 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1167634017272 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634017273 active site 1167634017274 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017275 PAS fold; Region: PAS_4; pfam08448 1167634017276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634017277 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634017278 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634017279 metal binding site [ion binding]; metal-binding site 1167634017280 active site 1167634017281 I-site; other site 1167634017282 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634017283 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1167634017284 RNA binding surface [nucleotide binding]; other site 1167634017285 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1167634017286 methionine gamma-lyase; Provisional; Region: PRK07503 1167634017287 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1167634017288 homodimer interface [polypeptide binding]; other site 1167634017289 substrate-cofactor binding pocket; other site 1167634017290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634017291 catalytic residue [active] 1167634017292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634017293 dimer interface [polypeptide binding]; other site 1167634017294 conserved gate region; other site 1167634017295 ABC-ATPase subunit interface; other site 1167634017296 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634017297 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1167634017298 Walker A/P-loop; other site 1167634017299 ATP binding site [chemical binding]; other site 1167634017300 Q-loop/lid; other site 1167634017301 ABC transporter signature motif; other site 1167634017302 Walker B; other site 1167634017303 D-loop; other site 1167634017304 H-loop/switch region; other site 1167634017305 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1167634017306 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1167634017307 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1167634017308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634017309 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634017310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634017311 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634017312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634017313 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1167634017314 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1167634017315 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1167634017316 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 1167634017317 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634017318 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1167634017319 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1167634017320 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 1167634017321 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1167634017322 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1167634017323 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634017324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634017325 DNA-binding site [nucleotide binding]; DNA binding site 1167634017326 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634017327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634017328 homodimer interface [polypeptide binding]; other site 1167634017329 catalytic residue [active] 1167634017330 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1167634017331 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1167634017332 catalytic loop [active] 1167634017333 iron binding site [ion binding]; other site 1167634017334 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1167634017335 FAD binding pocket [chemical binding]; other site 1167634017336 conserved FAD binding motif [chemical binding]; other site 1167634017337 phosphate binding motif [ion binding]; other site 1167634017338 beta-alpha-beta structure motif; other site 1167634017339 NAD binding pocket [chemical binding]; other site 1167634017340 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1167634017341 active site 1167634017342 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 1167634017343 putative hydrophobic ligand binding site [chemical binding]; other site 1167634017344 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1167634017345 DinB superfamily; Region: DinB_2; pfam12867 1167634017346 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 1167634017347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634017348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634017349 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634017350 putative effector binding pocket; other site 1167634017351 dimerization interface [polypeptide binding]; other site 1167634017352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634017353 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634017354 putative substrate translocation pore; other site 1167634017355 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1167634017356 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1167634017357 conserved cys residue [active] 1167634017358 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634017359 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 1167634017360 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1167634017361 putative dimer interface [polypeptide binding]; other site 1167634017362 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634017363 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1167634017364 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 1167634017365 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1167634017366 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1167634017367 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1167634017368 DNA-binding site [nucleotide binding]; DNA binding site 1167634017369 RNA-binding motif; other site 1167634017370 Cupin domain; Region: Cupin_2; cl17218 1167634017371 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634017372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634017373 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1167634017374 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1167634017375 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634017376 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634017377 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1167634017378 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1167634017379 [2Fe-2S] cluster binding site [ion binding]; other site 1167634017380 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1167634017381 hydrophobic ligand binding site; other site 1167634017382 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1167634017383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634017384 TAP-like protein; Region: Abhydrolase_4; pfam08386 1167634017385 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1167634017386 active site 1167634017387 cosubstrate binding site; other site 1167634017388 substrate binding site [chemical binding]; other site 1167634017389 catalytic site [active] 1167634017390 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 1167634017391 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1167634017392 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1167634017393 acyl-activating enzyme (AAE) consensus motif; other site 1167634017394 AMP binding site [chemical binding]; other site 1167634017395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634017396 S-adenosylmethionine binding site [chemical binding]; other site 1167634017397 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634017398 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1167634017399 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1167634017400 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1167634017401 active site 1167634017402 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1167634017403 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1167634017404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634017405 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1167634017406 Enoylreductase; Region: PKS_ER; smart00829 1167634017407 NAD(P) binding site [chemical binding]; other site 1167634017408 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1167634017409 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1167634017410 putative NADP binding site [chemical binding]; other site 1167634017411 active site 1167634017412 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1167634017413 thioester reductase domain; Region: Thioester-redct; TIGR01746 1167634017414 Male sterility protein; Region: NAD_binding_4; pfam07993 1167634017415 NAD(P) binding site [chemical binding]; other site 1167634017416 active site 1167634017417 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 1167634017418 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1167634017419 active site 1167634017420 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1167634017421 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634017422 acyl-activating enzyme (AAE) consensus motif; other site 1167634017423 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1167634017424 putative AMP binding site [chemical binding]; other site 1167634017425 putative active site [active] 1167634017426 acyl-activating enzyme (AAE) consensus motif; other site 1167634017427 putative CoA binding site [chemical binding]; other site 1167634017428 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1167634017429 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1167634017430 DctM-like transporters; Region: DctM; pfam06808 1167634017431 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1167634017432 PAS domain; Region: PAS_9; pfam13426 1167634017433 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634017434 putative active site [active] 1167634017435 heme pocket [chemical binding]; other site 1167634017436 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634017437 DNA binding residues [nucleotide binding] 1167634017438 dimerization interface [polypeptide binding]; other site 1167634017439 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1167634017440 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1167634017441 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1167634017442 dimer interface [polypeptide binding]; other site 1167634017443 active site 1167634017444 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 1167634017445 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 1167634017446 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634017447 putative C-terminal domain interface [polypeptide binding]; other site 1167634017448 putative GSH binding site (G-site) [chemical binding]; other site 1167634017449 putative dimer interface [polypeptide binding]; other site 1167634017450 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 1167634017451 putative N-terminal domain interface [polypeptide binding]; other site 1167634017452 putative dimer interface [polypeptide binding]; other site 1167634017453 putative substrate binding pocket (H-site) [chemical binding]; other site 1167634017454 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1167634017455 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1167634017456 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1167634017457 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1167634017458 Walker A/P-loop; other site 1167634017459 ATP binding site [chemical binding]; other site 1167634017460 Q-loop/lid; other site 1167634017461 ABC transporter signature motif; other site 1167634017462 Walker B; other site 1167634017463 D-loop; other site 1167634017464 H-loop/switch region; other site 1167634017465 Protein of unknown function (DUF556); Region: DUF556; cl00822 1167634017466 PAS domain S-box; Region: sensory_box; TIGR00229 1167634017467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1167634017468 putative active site [active] 1167634017469 heme pocket [chemical binding]; other site 1167634017470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1167634017471 Histidine kinase; Region: HisKA_3; pfam07730 1167634017472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634017473 ATP binding site [chemical binding]; other site 1167634017474 Mg2+ binding site [ion binding]; other site 1167634017475 G-X-G motif; other site 1167634017476 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634017477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634017478 active site 1167634017479 phosphorylation site [posttranslational modification] 1167634017480 intermolecular recognition site; other site 1167634017481 dimerization interface [polypeptide binding]; other site 1167634017482 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634017483 DNA binding residues [nucleotide binding] 1167634017484 dimerization interface [polypeptide binding]; other site 1167634017485 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1167634017486 NMT1-like family; Region: NMT1_2; pfam13379 1167634017487 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634017488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634017489 dimer interface [polypeptide binding]; other site 1167634017490 conserved gate region; other site 1167634017491 putative PBP binding loops; other site 1167634017492 ABC-ATPase subunit interface; other site 1167634017493 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1167634017494 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1167634017495 Walker A/P-loop; other site 1167634017496 ATP binding site [chemical binding]; other site 1167634017497 Q-loop/lid; other site 1167634017498 ABC transporter signature motif; other site 1167634017499 Walker B; other site 1167634017500 D-loop; other site 1167634017501 H-loop/switch region; other site 1167634017502 cyanate hydratase; Validated; Region: PRK02866 1167634017503 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1167634017504 oligomer interface [polypeptide binding]; other site 1167634017505 active site 1167634017506 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1167634017507 dimer interface [polypeptide binding]; other site 1167634017508 pyridoxal binding site [chemical binding]; other site 1167634017509 ATP binding site [chemical binding]; other site 1167634017510 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1167634017511 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1167634017512 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1167634017513 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1167634017514 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1167634017515 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1167634017516 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1167634017517 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 1167634017518 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1167634017519 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1167634017520 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1167634017521 Surface antigen; Region: Bac_surface_Ag; pfam01103 1167634017522 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1167634017523 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 1167634017524 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634017525 FecR protein; Region: FecR; pfam04773 1167634017526 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1167634017527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634017528 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1167634017529 Secretin and TonB N terminus short domain; Region: STN; smart00965 1167634017530 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 1167634017531 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1167634017532 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1167634017533 FecR protein; Region: FecR; pfam04773 1167634017534 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1167634017535 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1167634017536 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1167634017537 DNA binding residues [nucleotide binding] 1167634017538 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1167634017539 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634017540 sequence-specific DNA binding site [nucleotide binding]; other site 1167634017541 salt bridge; other site 1167634017542 Cupin domain; Region: Cupin_2; pfam07883 1167634017543 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1167634017544 intersubunit interface [polypeptide binding]; other site 1167634017545 active site 1167634017546 Zn2+ binding site [ion binding]; other site 1167634017547 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1167634017548 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1167634017549 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1167634017550 N-terminal domain interface [polypeptide binding]; other site 1167634017551 dimer interface [polypeptide binding]; other site 1167634017552 substrate binding pocket (H-site) [chemical binding]; other site 1167634017553 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017554 TAP-like protein; Region: Abhydrolase_4; pfam08386 1167634017555 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1167634017556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634017557 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1167634017558 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017559 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1167634017560 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1167634017561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634017562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634017563 dimerization interface [polypeptide binding]; other site 1167634017564 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017565 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1167634017566 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1167634017567 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1167634017568 classical (c) SDRs; Region: SDR_c; cd05233 1167634017569 NAD(P) binding site [chemical binding]; other site 1167634017570 active site 1167634017571 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017572 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1167634017573 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1167634017574 active site 1167634017575 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1167634017576 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017577 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017578 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1167634017579 CoA binding domain; Region: CoA_binding_2; pfam13380 1167634017580 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1167634017581 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1167634017582 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1167634017583 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634017584 substrate binding site [chemical binding]; other site 1167634017585 oxyanion hole (OAH) forming residues; other site 1167634017586 trimer interface [polypeptide binding]; other site 1167634017587 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1167634017588 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634017589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1167634017590 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1167634017591 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634017592 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1167634017593 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1167634017594 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1167634017595 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1167634017596 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1167634017597 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634017598 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634017599 TM-ABC transporter signature motif; other site 1167634017600 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634017601 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634017602 TM-ABC transporter signature motif; other site 1167634017603 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634017604 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634017605 Walker A/P-loop; other site 1167634017606 ATP binding site [chemical binding]; other site 1167634017607 Q-loop/lid; other site 1167634017608 ABC transporter signature motif; other site 1167634017609 Walker B; other site 1167634017610 D-loop; other site 1167634017611 H-loop/switch region; other site 1167634017612 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634017613 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634017614 Walker A/P-loop; other site 1167634017615 ATP binding site [chemical binding]; other site 1167634017616 Q-loop/lid; other site 1167634017617 ABC transporter signature motif; other site 1167634017618 Walker B; other site 1167634017619 D-loop; other site 1167634017620 H-loop/switch region; other site 1167634017621 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634017622 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634017623 DNA-binding site [nucleotide binding]; DNA binding site 1167634017624 FCD domain; Region: FCD; pfam07729 1167634017625 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634017626 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1167634017627 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634017628 Protein of unknown function, DUF486; Region: DUF486; cl01236 1167634017629 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1167634017630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634017631 active site 1167634017632 phosphorylation site [posttranslational modification] 1167634017633 intermolecular recognition site; other site 1167634017634 dimerization interface [polypeptide binding]; other site 1167634017635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634017636 Walker A motif; other site 1167634017637 ATP binding site [chemical binding]; other site 1167634017638 Walker B motif; other site 1167634017639 arginine finger; other site 1167634017640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634017641 dimer interface [polypeptide binding]; other site 1167634017642 phosphorylation site [posttranslational modification] 1167634017643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634017644 ATP binding site [chemical binding]; other site 1167634017645 Mg2+ binding site [ion binding]; other site 1167634017646 G-X-G motif; other site 1167634017647 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1167634017648 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1167634017649 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1167634017650 dimerization interface [polypeptide binding]; other site 1167634017651 LysR family transcriptional regulator; Provisional; Region: PRK14997 1167634017652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634017653 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634017654 putative effector binding pocket; other site 1167634017655 dimerization interface [polypeptide binding]; other site 1167634017656 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1167634017657 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1167634017658 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1167634017659 N-terminal domain interface [polypeptide binding]; other site 1167634017660 dimer interface [polypeptide binding]; other site 1167634017661 substrate binding pocket (H-site) [chemical binding]; other site 1167634017662 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634017663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634017664 metal binding site [ion binding]; metal-binding site 1167634017665 active site 1167634017666 I-site; other site 1167634017667 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1167634017668 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1167634017669 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1167634017670 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1167634017671 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1167634017672 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1167634017673 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1167634017674 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1167634017675 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1167634017676 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1167634017677 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1167634017678 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1167634017679 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1167634017680 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1167634017681 active site 1167634017682 metal binding site [ion binding]; metal-binding site 1167634017683 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1167634017684 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634017685 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1167634017686 hydroperoxidase II; Provisional; Region: katE; PRK11249 1167634017687 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1167634017688 heme binding pocket [chemical binding]; other site 1167634017689 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1167634017690 domain interactions; other site 1167634017691 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1167634017692 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634017693 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634017694 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1167634017695 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1167634017696 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1167634017697 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1167634017698 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1167634017699 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1167634017700 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1167634017701 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1167634017702 Fe-S cluster binding site [ion binding]; other site 1167634017703 active site 1167634017704 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1167634017705 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1167634017706 catalytic triad [active] 1167634017707 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1167634017708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634017709 DNA-binding site [nucleotide binding]; DNA binding site 1167634017710 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634017711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634017712 homodimer interface [polypeptide binding]; other site 1167634017713 catalytic residue [active] 1167634017714 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1167634017715 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1167634017716 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1167634017717 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634017718 catalytic residue [active] 1167634017719 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1167634017720 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1167634017721 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1167634017722 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1167634017723 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1167634017724 Ligand binding site; other site 1167634017725 metal-binding site 1167634017726 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1167634017727 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1167634017728 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1167634017729 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1167634017730 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1167634017731 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1167634017732 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1167634017733 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1167634017734 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1167634017735 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634017736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634017737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634017738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634017739 DNA-binding site [nucleotide binding]; DNA binding site 1167634017740 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634017741 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634017742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634017743 homodimer interface [polypeptide binding]; other site 1167634017744 catalytic residue [active] 1167634017745 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1167634017746 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634017747 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1167634017748 BON domain; Region: BON; pfam04972 1167634017749 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1167634017750 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1167634017751 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1167634017752 NAD binding site [chemical binding]; other site 1167634017753 putative substrate binding site 2 [chemical binding]; other site 1167634017754 putative substrate binding site 1 [chemical binding]; other site 1167634017755 active site 1167634017756 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634017757 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1167634017758 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1167634017759 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1167634017760 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1167634017761 putative active site [active] 1167634017762 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1167634017763 active site 1167634017764 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1167634017765 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1167634017766 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1167634017767 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1167634017768 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1167634017769 putative active site [active] 1167634017770 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1167634017771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634017772 active site 1167634017773 motif I; other site 1167634017774 motif II; other site 1167634017775 classical (c) SDRs; Region: SDR_c; cd05233 1167634017776 NAD(P) binding site [chemical binding]; other site 1167634017777 active site 1167634017778 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1167634017779 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1167634017780 putative ADP-binding pocket [chemical binding]; other site 1167634017781 BON domain; Region: BON; pfam04972 1167634017782 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1167634017783 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634017784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634017785 Walker A/P-loop; other site 1167634017786 ATP binding site [chemical binding]; other site 1167634017787 Q-loop/lid; other site 1167634017788 ABC transporter signature motif; other site 1167634017789 Walker B; other site 1167634017790 D-loop; other site 1167634017791 H-loop/switch region; other site 1167634017792 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1167634017793 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634017794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634017795 active site 1167634017796 phosphorylation site [posttranslational modification] 1167634017797 intermolecular recognition site; other site 1167634017798 dimerization interface [polypeptide binding]; other site 1167634017799 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1167634017800 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1167634017801 active site 1167634017802 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1167634017803 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1167634017804 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1167634017805 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 1167634017806 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1167634017807 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1167634017808 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1167634017809 Predicted membrane protein [Function unknown]; Region: COG2323 1167634017810 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1167634017811 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1167634017812 Low affinity iron permease; Region: Iron_permease; pfam04120 1167634017813 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1167634017814 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1167634017815 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1167634017816 putative catalytic site [active] 1167634017817 putative metal binding site [ion binding]; other site 1167634017818 putative phosphate binding site [ion binding]; other site 1167634017819 putative catalytic site [active] 1167634017820 putative phosphate binding site [ion binding]; other site 1167634017821 putative metal binding site [ion binding]; other site 1167634017822 cardiolipin synthase 2; Provisional; Region: PRK11263 1167634017823 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1167634017824 putative active site [active] 1167634017825 catalytic site [active] 1167634017826 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1167634017827 putative active site [active] 1167634017828 catalytic site [active] 1167634017829 Predicted integral membrane protein [Function unknown]; Region: COG0392 1167634017830 glycogen synthase; Provisional; Region: glgA; PRK00654 1167634017831 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1167634017832 ADP-binding pocket [chemical binding]; other site 1167634017833 homodimer interface [polypeptide binding]; other site 1167634017834 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1167634017835 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1167634017836 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1167634017837 active site 1167634017838 homodimer interface [polypeptide binding]; other site 1167634017839 catalytic site [active] 1167634017840 acceptor binding site [chemical binding]; other site 1167634017841 trehalose synthase; Region: treS_nterm; TIGR02456 1167634017842 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1167634017843 active site 1167634017844 catalytic site [active] 1167634017845 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1167634017846 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1167634017847 glycogen branching enzyme; Provisional; Region: PRK05402 1167634017848 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1167634017849 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1167634017850 active site 1167634017851 catalytic site [active] 1167634017852 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1167634017853 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1167634017854 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1167634017855 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1167634017856 active site 1167634017857 catalytic site [active] 1167634017858 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1167634017859 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1167634017860 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1167634017861 catalytic site [active] 1167634017862 active site 1167634017863 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1167634017864 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1167634017865 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1167634017866 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1167634017867 active site 1167634017868 catalytic site [active] 1167634017869 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1167634017870 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1167634017871 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1167634017872 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1167634017873 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1167634017874 active site 1167634017875 DNA binding site [nucleotide binding] 1167634017876 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1167634017877 DNA binding site [nucleotide binding] 1167634017878 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1167634017879 nucleotide binding site [chemical binding]; other site 1167634017880 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1167634017881 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1167634017882 putative DNA binding site [nucleotide binding]; other site 1167634017883 putative homodimer interface [polypeptide binding]; other site 1167634017884 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1167634017885 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1167634017886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634017887 active site 1167634017888 phosphorylation site [posttranslational modification] 1167634017889 intermolecular recognition site; other site 1167634017890 dimerization interface [polypeptide binding]; other site 1167634017891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634017892 Walker A motif; other site 1167634017893 ATP binding site [chemical binding]; other site 1167634017894 Walker B motif; other site 1167634017895 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1167634017896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634017897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634017898 dimer interface [polypeptide binding]; other site 1167634017899 phosphorylation site [posttranslational modification] 1167634017900 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1167634017901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1167634017902 acetylornithine deacetylase; Provisional; Region: PRK06837 1167634017903 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1167634017904 metal binding site [ion binding]; metal-binding site 1167634017905 dimer interface [polypeptide binding]; other site 1167634017906 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1167634017907 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1167634017908 active site 1167634017909 ATP binding site [chemical binding]; other site 1167634017910 substrate binding site [chemical binding]; other site 1167634017911 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1167634017912 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1167634017913 inhibitor-cofactor binding pocket; inhibition site 1167634017914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634017915 catalytic residue [active] 1167634017916 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634017917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634017918 DNA-binding site [nucleotide binding]; DNA binding site 1167634017919 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634017920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634017921 homodimer interface [polypeptide binding]; other site 1167634017922 catalytic residue [active] 1167634017923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634017924 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634017925 putative substrate translocation pore; other site 1167634017926 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1167634017927 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634017928 HD domain; Region: HD_5; pfam13487 1167634017929 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634017930 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634017931 DNA binding residues [nucleotide binding] 1167634017932 dimerization interface [polypeptide binding]; other site 1167634017933 Beta-lactamase; Region: Beta-lactamase; pfam00144 1167634017934 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1167634017935 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1167634017936 RNA ligase; Region: RNA_ligase; pfam09414 1167634017937 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1167634017938 Zn2+ binding site [ion binding]; other site 1167634017939 Mg2+ binding site [ion binding]; other site 1167634017940 AAA domain; Region: AAA_33; pfam13671 1167634017941 AAA domain; Region: AAA_17; pfam13207 1167634017942 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634017943 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1167634017944 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634017945 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1167634017946 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1167634017947 short chain dehydrogenase; Provisional; Region: PRK06138 1167634017948 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1167634017949 NAD binding site [chemical binding]; other site 1167634017950 homotetramer interface [polypeptide binding]; other site 1167634017951 homodimer interface [polypeptide binding]; other site 1167634017952 active site 1167634017953 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1167634017954 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1167634017955 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1167634017956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634017957 dimer interface [polypeptide binding]; other site 1167634017958 conserved gate region; other site 1167634017959 putative PBP binding loops; other site 1167634017960 ABC-ATPase subunit interface; other site 1167634017961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634017962 dimer interface [polypeptide binding]; other site 1167634017963 conserved gate region; other site 1167634017964 putative PBP binding loops; other site 1167634017965 ABC-ATPase subunit interface; other site 1167634017966 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634017967 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634017968 Walker A/P-loop; other site 1167634017969 ATP binding site [chemical binding]; other site 1167634017970 Q-loop/lid; other site 1167634017971 ABC transporter signature motif; other site 1167634017972 Walker B; other site 1167634017973 D-loop; other site 1167634017974 H-loop/switch region; other site 1167634017975 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634017976 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634017977 substrate binding pocket [chemical binding]; other site 1167634017978 membrane-bound complex binding site; other site 1167634017979 hinge residues; other site 1167634017980 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1167634017981 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1167634017982 active site pocket [active] 1167634017983 choline dehydrogenase; Validated; Region: PRK02106 1167634017984 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1167634017985 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1167634017986 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1167634017987 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1167634017988 shikimate binding site; other site 1167634017989 NAD(P) binding site [chemical binding]; other site 1167634017990 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1167634017991 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1167634017992 PYR/PP interface [polypeptide binding]; other site 1167634017993 dimer interface [polypeptide binding]; other site 1167634017994 TPP binding site [chemical binding]; other site 1167634017995 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1167634017996 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1167634017997 TPP-binding site [chemical binding]; other site 1167634017998 dimer interface [polypeptide binding]; other site 1167634017999 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634018000 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634018001 DNA-binding site [nucleotide binding]; DNA binding site 1167634018002 FCD domain; Region: FCD; pfam07729 1167634018003 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1167634018004 active site 1167634018005 NAD binding site [chemical binding]; other site 1167634018006 metal binding site [ion binding]; metal-binding site 1167634018007 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1167634018008 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 1167634018009 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1167634018010 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634018011 short chain dehydrogenase; Provisional; Region: PRK12829 1167634018012 classical (c) SDRs; Region: SDR_c; cd05233 1167634018013 NAD(P) binding site [chemical binding]; other site 1167634018014 active site 1167634018015 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1167634018016 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1167634018017 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634018018 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634018019 TM-ABC transporter signature motif; other site 1167634018020 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634018021 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634018022 TM-ABC transporter signature motif; other site 1167634018023 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634018024 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634018025 Walker A/P-loop; other site 1167634018026 ATP binding site [chemical binding]; other site 1167634018027 Q-loop/lid; other site 1167634018028 ABC transporter signature motif; other site 1167634018029 Walker B; other site 1167634018030 D-loop; other site 1167634018031 H-loop/switch region; other site 1167634018032 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1167634018033 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1167634018034 Walker A/P-loop; other site 1167634018035 ATP binding site [chemical binding]; other site 1167634018036 Q-loop/lid; other site 1167634018037 ABC transporter signature motif; other site 1167634018038 Walker B; other site 1167634018039 D-loop; other site 1167634018040 H-loop/switch region; other site 1167634018041 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1167634018042 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1167634018043 NAD(P) binding site [chemical binding]; other site 1167634018044 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1167634018045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634018046 NAD(P) binding site [chemical binding]; other site 1167634018047 active site 1167634018048 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634018049 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634018050 N-terminal plug; other site 1167634018051 ligand-binding site [chemical binding]; other site 1167634018052 Pirin-related protein [General function prediction only]; Region: COG1741 1167634018053 Pirin; Region: Pirin; pfam02678 1167634018054 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1167634018055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634018056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634018057 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634018058 dimerization interface [polypeptide binding]; other site 1167634018059 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634018060 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1167634018061 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1167634018062 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1167634018063 acyl-activating enzyme (AAE) consensus motif; other site 1167634018064 putative AMP binding site [chemical binding]; other site 1167634018065 putative active site [active] 1167634018066 acyl-activating enzyme (AAE) consensus motif; other site 1167634018067 putative CoA binding site [chemical binding]; other site 1167634018068 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1167634018069 NAD(P) binding site [chemical binding]; other site 1167634018070 short chain dehydrogenase; Provisional; Region: PRK07677 1167634018071 substrate binding site [chemical binding]; other site 1167634018072 homotetramer interface [polypeptide binding]; other site 1167634018073 active site 1167634018074 homodimer interface [polypeptide binding]; other site 1167634018075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634018076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634018077 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634018078 putative effector binding pocket; other site 1167634018079 dimerization interface [polypeptide binding]; other site 1167634018080 aconitate hydratase; Provisional; Region: acnA; PRK12881 1167634018081 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1167634018082 substrate binding site [chemical binding]; other site 1167634018083 ligand binding site [chemical binding]; other site 1167634018084 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1167634018085 substrate binding site [chemical binding]; other site 1167634018086 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1167634018087 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1167634018088 ligand binding site [chemical binding]; other site 1167634018089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634018090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634018091 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1167634018092 putative substrate binding pocket [chemical binding]; other site 1167634018093 putative dimerization interface [polypeptide binding]; other site 1167634018094 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1167634018095 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1167634018096 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634018097 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1167634018098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634018099 putative substrate translocation pore; other site 1167634018100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634018101 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1167634018102 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1167634018103 FAD binding pocket [chemical binding]; other site 1167634018104 FAD binding motif [chemical binding]; other site 1167634018105 phosphate binding motif [ion binding]; other site 1167634018106 NAD binding pocket [chemical binding]; other site 1167634018107 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634018108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634018109 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634018110 putative effector binding pocket; other site 1167634018111 dimerization interface [polypeptide binding]; other site 1167634018112 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1167634018113 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1167634018114 putative active site [active] 1167634018115 metal binding site [ion binding]; metal-binding site 1167634018116 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 1167634018117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 1167634018118 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 1167634018119 elongation factor P; Validated; Region: PRK00529 1167634018120 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1167634018121 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1167634018122 RNA binding site [nucleotide binding]; other site 1167634018123 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1167634018124 RNA binding site [nucleotide binding]; other site 1167634018125 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 1167634018126 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 1167634018127 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1167634018128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1167634018129 Walker A motif; other site 1167634018130 ATP binding site [chemical binding]; other site 1167634018131 Walker B motif; other site 1167634018132 arginine finger; other site 1167634018133 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1167634018134 Predicted membrane protein [Function unknown]; Region: COG4655 1167634018135 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 1167634018136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1167634018137 TPR motif; other site 1167634018138 binding surface 1167634018139 TPR repeat; Region: TPR_11; pfam13414 1167634018140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1167634018141 binding surface 1167634018142 TPR motif; other site 1167634018143 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1167634018144 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1167634018145 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1167634018146 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1167634018147 ATP binding site [chemical binding]; other site 1167634018148 Walker A motif; other site 1167634018149 hexamer interface [polypeptide binding]; other site 1167634018150 Walker B motif; other site 1167634018151 AAA domain; Region: AAA_31; pfam13614 1167634018152 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1167634018153 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1167634018154 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1167634018155 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1167634018156 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1167634018157 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1167634018158 TadE-like protein; Region: TadE; pfam07811 1167634018159 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1167634018160 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1167634018161 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1167634018162 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1167634018163 MarR family; Region: MarR_2; pfam12802 1167634018164 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1167634018165 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634018166 Walker A/P-loop; other site 1167634018167 ATP binding site [chemical binding]; other site 1167634018168 Q-loop/lid; other site 1167634018169 ABC transporter signature motif; other site 1167634018170 Walker B; other site 1167634018171 D-loop; other site 1167634018172 H-loop/switch region; other site 1167634018173 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634018174 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634018175 Walker A/P-loop; other site 1167634018176 ATP binding site [chemical binding]; other site 1167634018177 Q-loop/lid; other site 1167634018178 ABC transporter signature motif; other site 1167634018179 Walker B; other site 1167634018180 D-loop; other site 1167634018181 H-loop/switch region; other site 1167634018182 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1167634018183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634018184 dimer interface [polypeptide binding]; other site 1167634018185 conserved gate region; other site 1167634018186 putative PBP binding loops; other site 1167634018187 ABC-ATPase subunit interface; other site 1167634018188 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634018189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634018190 dimer interface [polypeptide binding]; other site 1167634018191 putative PBP binding loops; other site 1167634018192 ABC-ATPase subunit interface; other site 1167634018193 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 1167634018194 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1167634018195 Staphylococcal nuclease homologues; Region: SNc; smart00318 1167634018196 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1167634018197 Catalytic site; other site 1167634018198 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1167634018199 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1167634018200 oligomer interface [polypeptide binding]; other site 1167634018201 metal binding site [ion binding]; metal-binding site 1167634018202 metal binding site [ion binding]; metal-binding site 1167634018203 putative Cl binding site [ion binding]; other site 1167634018204 basic sphincter; other site 1167634018205 hydrophobic gate; other site 1167634018206 periplasmic entrance; other site 1167634018207 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1167634018208 Part of AAA domain; Region: AAA_19; pfam13245 1167634018209 Family description; Region: UvrD_C_2; pfam13538 1167634018210 Protein of unknown function DUF72; Region: DUF72; pfam01904 1167634018211 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634018212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634018213 DNA-binding site [nucleotide binding]; DNA binding site 1167634018214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634018215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634018216 homodimer interface [polypeptide binding]; other site 1167634018217 catalytic residue [active] 1167634018218 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1167634018219 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1167634018220 inhibitor-cofactor binding pocket; inhibition site 1167634018221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634018222 catalytic residue [active] 1167634018223 succinic semialdehyde dehydrogenase; Region: PLN02278 1167634018224 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1167634018225 tetramerization interface [polypeptide binding]; other site 1167634018226 NAD(P) binding site [chemical binding]; other site 1167634018227 catalytic residues [active] 1167634018228 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1167634018229 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1167634018230 active site 1167634018231 NAD-dependent deacetylase; Provisional; Region: PRK05333 1167634018232 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1167634018233 NAD+ binding site [chemical binding]; other site 1167634018234 substrate binding site [chemical binding]; other site 1167634018235 Zn binding site [ion binding]; other site 1167634018236 serine O-acetyltransferase; Region: cysE; TIGR01172 1167634018237 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1167634018238 trimer interface [polypeptide binding]; other site 1167634018239 active site 1167634018240 substrate binding site [chemical binding]; other site 1167634018241 CoA binding site [chemical binding]; other site 1167634018242 UDP-glucose 4-epimerase; Region: PLN02240 1167634018243 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1167634018244 NAD binding site [chemical binding]; other site 1167634018245 homodimer interface [polypeptide binding]; other site 1167634018246 active site 1167634018247 substrate binding site [chemical binding]; other site 1167634018248 Phosphoglucose isomerase; Region: PGI; pfam00342 1167634018249 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1167634018250 active site 1167634018251 dimer interface [polypeptide binding]; other site 1167634018252 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1167634018253 dimer interface [polypeptide binding]; other site 1167634018254 active site 1167634018255 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1167634018256 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1167634018257 active site 1167634018258 substrate binding site [chemical binding]; other site 1167634018259 metal binding site [ion binding]; metal-binding site 1167634018260 tyrosine kinase; Provisional; Region: PRK11519 1167634018261 Chain length determinant protein; Region: Wzz; pfam02706 1167634018262 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1167634018263 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1167634018264 polysaccharide export protein Wza; Provisional; Region: PRK15078 1167634018265 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1167634018266 SLBB domain; Region: SLBB; pfam10531 1167634018267 SLBB domain; Region: SLBB; pfam10531 1167634018268 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1167634018269 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1167634018270 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1167634018271 nudix motif; other site 1167634018272 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1167634018273 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1167634018274 Substrate binding site; other site 1167634018275 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1167634018276 Predicted integral membrane protein [Function unknown]; Region: COG5652 1167634018277 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1167634018278 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1167634018279 NADP-binding site; other site 1167634018280 homotetramer interface [polypeptide binding]; other site 1167634018281 substrate binding site [chemical binding]; other site 1167634018282 homodimer interface [polypeptide binding]; other site 1167634018283 active site 1167634018284 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1167634018285 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1167634018286 NADP binding site [chemical binding]; other site 1167634018287 active site 1167634018288 putative substrate binding site [chemical binding]; other site 1167634018289 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1167634018290 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1167634018291 metal-binding site 1167634018292 O-Antigen ligase; Region: Wzy_C; pfam04932 1167634018293 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1167634018294 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1167634018295 putative ADP-binding pocket [chemical binding]; other site 1167634018296 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1167634018297 putative metal binding site; other site 1167634018298 putative acyl transferase; Provisional; Region: PRK10502 1167634018299 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1167634018300 putative trimer interface [polypeptide binding]; other site 1167634018301 putative active site [active] 1167634018302 putative substrate binding site [chemical binding]; other site 1167634018303 putative CoA binding site [chemical binding]; other site 1167634018304 putative glycosyl transferase; Provisional; Region: PRK10307 1167634018305 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1167634018306 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634018307 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634018308 dimerization interface [polypeptide binding]; other site 1167634018309 DNA binding residues [nucleotide binding] 1167634018310 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634018311 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634018312 DNA binding residues [nucleotide binding] 1167634018313 dimerization interface [polypeptide binding]; other site 1167634018314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634018315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634018316 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1167634018317 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634018318 active site 1167634018319 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1167634018320 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 1167634018321 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1167634018322 dimer interface [polypeptide binding]; other site 1167634018323 active site 1167634018324 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634018325 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1167634018326 substrate binding site [chemical binding]; other site 1167634018327 oxyanion hole (OAH) forming residues; other site 1167634018328 trimer interface [polypeptide binding]; other site 1167634018329 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 1167634018330 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1167634018331 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634018332 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 1167634018333 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1167634018334 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1167634018335 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634018336 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1167634018337 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634018338 substrate binding site [chemical binding]; other site 1167634018339 oxyanion hole (OAH) forming residues; other site 1167634018340 trimer interface [polypeptide binding]; other site 1167634018341 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1167634018342 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1167634018343 dimer interface [polypeptide binding]; other site 1167634018344 active site 1167634018345 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1167634018346 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 1167634018347 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1167634018348 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1167634018349 acyl-activating enzyme (AAE) consensus motif; other site 1167634018350 putative AMP binding site [chemical binding]; other site 1167634018351 putative active site [active] 1167634018352 putative CoA binding site [chemical binding]; other site 1167634018353 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1167634018354 Sulfatase; Region: Sulfatase; cl17466 1167634018355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634018356 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1167634018357 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1167634018358 MarR family; Region: MarR_2; cl17246 1167634018359 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1167634018360 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1167634018361 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1167634018362 Walker A/P-loop; other site 1167634018363 ATP binding site [chemical binding]; other site 1167634018364 Q-loop/lid; other site 1167634018365 ABC transporter signature motif; other site 1167634018366 Walker B; other site 1167634018367 D-loop; other site 1167634018368 H-loop/switch region; other site 1167634018369 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1167634018370 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 1167634018371 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1167634018372 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1167634018373 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1167634018374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634018375 DNA-binding site [nucleotide binding]; DNA binding site 1167634018376 UTRA domain; Region: UTRA; pfam07702 1167634018377 Coenzyme A transferase; Region: CoA_trans; cl17247 1167634018378 Coenzyme A transferase; Region: CoA_trans; smart00882 1167634018379 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1167634018380 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634018381 substrate binding site [chemical binding]; other site 1167634018382 oxyanion hole (OAH) forming residues; other site 1167634018383 trimer interface [polypeptide binding]; other site 1167634018384 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634018385 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634018386 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634018387 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1167634018388 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634018389 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1167634018390 NAD-dependent deacetylase; Provisional; Region: PRK00481 1167634018391 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1167634018392 NAD+ binding site [chemical binding]; other site 1167634018393 substrate binding site [chemical binding]; other site 1167634018394 Zn binding site [ion binding]; other site 1167634018395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634018396 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1167634018397 non-specific DNA binding site [nucleotide binding]; other site 1167634018398 salt bridge; other site 1167634018399 sequence-specific DNA binding site [nucleotide binding]; other site 1167634018400 transcriptional regulator; Provisional; Region: PRK10632 1167634018401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634018402 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 1167634018403 putative effector binding pocket; other site 1167634018404 putative dimerization interface [polypeptide binding]; other site 1167634018405 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1167634018406 putative NAD(P) binding site [chemical binding]; other site 1167634018407 homodimer interface [polypeptide binding]; other site 1167634018408 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1167634018409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634018410 Coenzyme A binding pocket [chemical binding]; other site 1167634018411 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 1167634018412 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1167634018413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634018414 ABC transporter signature motif; other site 1167634018415 Walker B; other site 1167634018416 D-loop; other site 1167634018417 H-loop/switch region; other site 1167634018418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1167634018419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1167634018420 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1167634018421 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 1167634018422 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1167634018423 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1167634018424 nudix motif; other site 1167634018425 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1167634018426 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1167634018427 active site residue [active] 1167634018428 AAA ATPase domain; Region: AAA_16; pfam13191 1167634018429 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1167634018430 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1167634018431 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1167634018432 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1167634018433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634018434 dimer interface [polypeptide binding]; other site 1167634018435 phosphorylation site [posttranslational modification] 1167634018436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634018437 ATP binding site [chemical binding]; other site 1167634018438 Mg2+ binding site [ion binding]; other site 1167634018439 G-X-G motif; other site 1167634018440 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634018441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634018442 active site 1167634018443 phosphorylation site [posttranslational modification] 1167634018444 intermolecular recognition site; other site 1167634018445 dimerization interface [polypeptide binding]; other site 1167634018446 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1167634018447 putative binding surface; other site 1167634018448 active site 1167634018449 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634018450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634018451 active site 1167634018452 phosphorylation site [posttranslational modification] 1167634018453 intermolecular recognition site; other site 1167634018454 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634018455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634018456 dimer interface [polypeptide binding]; other site 1167634018457 phosphorylation site [posttranslational modification] 1167634018458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634018459 ATP binding site [chemical binding]; other site 1167634018460 Mg2+ binding site [ion binding]; other site 1167634018461 G-X-G motif; other site 1167634018462 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634018463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634018464 active site 1167634018465 phosphorylation site [posttranslational modification] 1167634018466 intermolecular recognition site; other site 1167634018467 dimerization interface [polypeptide binding]; other site 1167634018468 Cytochrome c; Region: Cytochrom_C; cl11414 1167634018469 Cytochrome c; Region: Cytochrom_C; cl11414 1167634018470 Cytochrome c [Energy production and conversion]; Region: COG3258 1167634018471 Cytochrome c; Region: Cytochrom_C; pfam00034 1167634018472 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1167634018473 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1167634018474 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 1167634018475 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1167634018476 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1167634018477 Low-spin heme binding site [chemical binding]; other site 1167634018478 Putative water exit pathway; other site 1167634018479 Binuclear center (active site) [active] 1167634018480 Putative proton exit pathway; other site 1167634018481 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1167634018482 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1167634018483 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 1167634018484 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1167634018485 Cytochrome c; Region: Cytochrom_C; pfam00034 1167634018486 Cytochrome c; Region: Cytochrom_C; pfam00034 1167634018487 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 1167634018488 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1167634018489 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1167634018490 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1167634018491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1167634018492 aspartate kinase; Reviewed; Region: PRK06635 1167634018493 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1167634018494 putative nucleotide binding site [chemical binding]; other site 1167634018495 putative catalytic residues [active] 1167634018496 putative Mg ion binding site [ion binding]; other site 1167634018497 putative aspartate binding site [chemical binding]; other site 1167634018498 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1167634018499 putative allosteric regulatory site; other site 1167634018500 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1167634018501 putative allosteric regulatory residue; other site 1167634018502 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1167634018503 Ligand Binding Site [chemical binding]; other site 1167634018504 TilS substrate binding domain; Region: TilS; pfam09179 1167634018505 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1167634018506 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1167634018507 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1167634018508 endonuclease III; Region: ENDO3c; smart00478 1167634018509 minor groove reading motif; other site 1167634018510 helix-hairpin-helix signature motif; other site 1167634018511 substrate binding pocket [chemical binding]; other site 1167634018512 active site 1167634018513 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1167634018514 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1167634018515 active site 1167634018516 HIGH motif; other site 1167634018517 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1167634018518 KMSKS motif; other site 1167634018519 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1167634018520 tRNA binding surface [nucleotide binding]; other site 1167634018521 anticodon binding site; other site 1167634018522 TPR repeat; Region: TPR_11; pfam13414 1167634018523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1167634018524 binding surface 1167634018525 TPR motif; other site 1167634018526 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1167634018527 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1167634018528 substrate binding site [chemical binding]; other site 1167634018529 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1167634018530 putative active site [active] 1167634018531 putative metal binding site [ion binding]; other site 1167634018532 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1167634018533 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1167634018534 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1167634018535 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1167634018536 Transporter associated domain; Region: CorC_HlyC; pfam03471 1167634018537 azurin; Region: azurin; TIGR02695 1167634018538 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1167634018539 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1167634018540 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1167634018541 nitrous-oxide reductase; Validated; Region: PRK02888 1167634018542 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1167634018543 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1167634018544 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1167634018545 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1167634018546 Walker A/P-loop; other site 1167634018547 ATP binding site [chemical binding]; other site 1167634018548 Q-loop/lid; other site 1167634018549 ABC transporter signature motif; other site 1167634018550 Walker B; other site 1167634018551 D-loop; other site 1167634018552 H-loop/switch region; other site 1167634018553 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1167634018554 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1167634018555 NosL; Region: NosL; pfam05573 1167634018556 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1167634018557 ApbE family; Region: ApbE; pfam02424 1167634018558 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1167634018559 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1167634018560 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1167634018561 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1167634018562 active site 1167634018563 dimerization interface [polypeptide binding]; other site 1167634018564 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1167634018565 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1167634018566 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634018567 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1167634018568 Bacterial transcriptional regulator; Region: IclR; pfam01614 1167634018569 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1167634018570 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1167634018571 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 1167634018572 Imelysin; Region: Peptidase_M75; cl09159 1167634018573 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1167634018574 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1167634018575 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 1167634018576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634018577 metabolite-proton symporter; Region: 2A0106; TIGR00883 1167634018578 putative substrate translocation pore; other site 1167634018579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634018580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634018581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634018582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1167634018583 dimerization interface [polypeptide binding]; other site 1167634018584 NMT1/THI5 like; Region: NMT1; pfam09084 1167634018585 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634018586 substrate binding pocket [chemical binding]; other site 1167634018587 membrane-bound complex binding site; other site 1167634018588 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1167634018589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1167634018590 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1167634018591 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1167634018592 Walker A/P-loop; other site 1167634018593 ATP binding site [chemical binding]; other site 1167634018594 Q-loop/lid; other site 1167634018595 ABC transporter signature motif; other site 1167634018596 Walker B; other site 1167634018597 D-loop; other site 1167634018598 H-loop/switch region; other site 1167634018599 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1167634018600 amidase; Provisional; Region: PRK09201 1167634018601 Amidase; Region: Amidase; cl11426 1167634018602 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634018603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634018604 DNA-binding site [nucleotide binding]; DNA binding site 1167634018605 FCD domain; Region: FCD; pfam07729 1167634018606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1167634018607 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1167634018608 Predicted flavoprotein [General function prediction only]; Region: COG0431 1167634018609 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1167634018610 Dodecin; Region: Dodecin; pfam07311 1167634018611 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634018612 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634018613 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1167634018614 putative effector binding pocket; other site 1167634018615 dimerization interface [polypeptide binding]; other site 1167634018616 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1167634018617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634018618 NAD(P) binding site [chemical binding]; other site 1167634018619 active site 1167634018620 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1167634018621 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1167634018622 putative NAD(P) binding site [chemical binding]; other site 1167634018623 dimer interface [polypeptide binding]; other site 1167634018624 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1167634018625 active site 1167634018626 catalytic residues [active] 1167634018627 Cupin domain; Region: Cupin_2; pfam07883 1167634018628 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1167634018629 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1167634018630 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1167634018631 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1167634018632 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1167634018633 MutS domain I; Region: MutS_I; pfam01624 1167634018634 MutS domain II; Region: MutS_II; pfam05188 1167634018635 MutS domain III; Region: MutS_III; pfam05192 1167634018636 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1167634018637 Walker A/P-loop; other site 1167634018638 ATP binding site [chemical binding]; other site 1167634018639 Q-loop/lid; other site 1167634018640 ABC transporter signature motif; other site 1167634018641 Walker B; other site 1167634018642 D-loop; other site 1167634018643 H-loop/switch region; other site 1167634018644 Cupin superfamily protein; Region: Cupin_4; pfam08007 1167634018645 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1167634018646 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1167634018647 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1167634018648 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1167634018649 dimer interface [polypeptide binding]; other site 1167634018650 active site 1167634018651 catalytic residue [active] 1167634018652 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1167634018653 Peptidase family M50; Region: Peptidase_M50; pfam02163 1167634018654 active site 1167634018655 putative substrate binding region [chemical binding]; other site 1167634018656 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1167634018657 Predicted metalloprotease [General function prediction only]; Region: COG2321 1167634018658 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1167634018659 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1167634018660 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634018661 putative DNA binding site [nucleotide binding]; other site 1167634018662 putative Zn2+ binding site [ion binding]; other site 1167634018663 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634018664 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1167634018665 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1167634018666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634018667 Coenzyme A binding pocket [chemical binding]; other site 1167634018668 PQQ-like domain; Region: PQQ_2; pfam13360 1167634018669 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1167634018670 dimer interface [polypeptide binding]; other site 1167634018671 putative tRNA-binding site [nucleotide binding]; other site 1167634018672 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1167634018673 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1167634018674 Active Sites [active] 1167634018675 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1167634018676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634018677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634018678 dimer interface [polypeptide binding]; other site 1167634018679 phosphorylation site [posttranslational modification] 1167634018680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634018681 ATP binding site [chemical binding]; other site 1167634018682 Mg2+ binding site [ion binding]; other site 1167634018683 G-X-G motif; other site 1167634018684 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1167634018685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634018686 active site 1167634018687 phosphorylation site [posttranslational modification] 1167634018688 intermolecular recognition site; other site 1167634018689 dimerization interface [polypeptide binding]; other site 1167634018690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634018691 DNA binding site [nucleotide binding] 1167634018692 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1167634018693 Fimbrial protein; Region: Fimbrial; cl01416 1167634018694 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 1167634018695 PapC N-terminal domain; Region: PapC_N; pfam13954 1167634018696 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1167634018697 PapC C-terminal domain; Region: PapC_C; pfam13953 1167634018698 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 1167634018699 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1167634018700 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1167634018701 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634018702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634018703 active site 1167634018704 phosphorylation site [posttranslational modification] 1167634018705 intermolecular recognition site; other site 1167634018706 dimerization interface [polypeptide binding]; other site 1167634018707 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1167634018708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1167634018709 dimer interface [polypeptide binding]; other site 1167634018710 phosphorylation site [posttranslational modification] 1167634018711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634018712 ATP binding site [chemical binding]; other site 1167634018713 Mg2+ binding site [ion binding]; other site 1167634018714 G-X-G motif; other site 1167634018715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634018716 Response regulator receiver domain; Region: Response_reg; pfam00072 1167634018717 active site 1167634018718 phosphorylation site [posttranslational modification] 1167634018719 intermolecular recognition site; other site 1167634018720 dimerization interface [polypeptide binding]; other site 1167634018721 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1167634018722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634018723 active site 1167634018724 phosphorylation site [posttranslational modification] 1167634018725 intermolecular recognition site; other site 1167634018726 dimerization interface [polypeptide binding]; other site 1167634018727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1167634018728 DNA binding residues [nucleotide binding] 1167634018729 dimerization interface [polypeptide binding]; other site 1167634018730 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1167634018731 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1167634018732 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1167634018733 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1167634018734 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1167634018735 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1167634018736 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1167634018737 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1167634018738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634018739 dimerization interface [polypeptide binding]; other site 1167634018740 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634018741 dimer interface [polypeptide binding]; other site 1167634018742 putative CheW interface [polypeptide binding]; other site 1167634018743 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1167634018744 catalytic triad [active] 1167634018745 putative active site [active] 1167634018746 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1167634018747 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1167634018748 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1167634018749 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1167634018750 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1167634018751 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1167634018752 N-terminal plug; other site 1167634018753 ligand-binding site [chemical binding]; other site 1167634018754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634018755 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1167634018756 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1167634018757 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1167634018758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634018759 active site 1167634018760 phosphorylation site [posttranslational modification] 1167634018761 intermolecular recognition site; other site 1167634018762 dimerization interface [polypeptide binding]; other site 1167634018763 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1167634018764 DNA binding site [nucleotide binding] 1167634018765 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1167634018766 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1167634018767 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1167634018768 dimer interface [polypeptide binding]; other site 1167634018769 putative CheW interface [polypeptide binding]; other site 1167634018770 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634018771 LysE type translocator; Region: LysE; cl00565 1167634018772 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1167634018773 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1167634018774 putative DNA binding site [nucleotide binding]; other site 1167634018775 putative Zn2+ binding site [ion binding]; other site 1167634018776 AsnC family; Region: AsnC_trans_reg; pfam01037 1167634018777 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1167634018778 Putative amidotransferase; Region: DUF4066; pfam13278 1167634018779 conserved cys residue [active] 1167634018780 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1167634018781 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 1167634018782 putative active site [active] 1167634018783 catalytic site [active] 1167634018784 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 1167634018785 putative active site [active] 1167634018786 catalytic site [active] 1167634018787 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1167634018788 CoenzymeA binding site [chemical binding]; other site 1167634018789 subunit interaction site [polypeptide binding]; other site 1167634018790 PHB binding site; other site 1167634018791 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1167634018792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634018793 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1167634018794 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1167634018795 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1167634018796 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1167634018797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634018798 putative substrate translocation pore; other site 1167634018799 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634018800 EamA-like transporter family; Region: EamA; pfam00892 1167634018801 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634018802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634018803 DNA-binding site [nucleotide binding]; DNA binding site 1167634018804 FCD domain; Region: FCD; pfam07729 1167634018805 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634018806 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1167634018807 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1167634018808 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1167634018809 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1167634018810 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1167634018811 protein binding site [polypeptide binding]; other site 1167634018812 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1167634018813 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1167634018814 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1167634018815 transmembrane helices; other site 1167634018816 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1167634018817 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1167634018818 catalytic residues [active] 1167634018819 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1167634018820 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1167634018821 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1167634018822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1167634018823 active site 1167634018824 phosphorylation site [posttranslational modification] 1167634018825 intermolecular recognition site; other site 1167634018826 dimerization interface [polypeptide binding]; other site 1167634018827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1167634018828 DNA binding site [nucleotide binding] 1167634018829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1167634018830 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1167634018831 dimerization interface [polypeptide binding]; other site 1167634018832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1167634018833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1167634018834 ATP binding site [chemical binding]; other site 1167634018835 Mg2+ binding site [ion binding]; other site 1167634018836 G-X-G motif; other site 1167634018837 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1167634018838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634018839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634018840 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1167634018841 putative dimerization interface [polypeptide binding]; other site 1167634018842 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1167634018843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634018844 dimer interface [polypeptide binding]; other site 1167634018845 conserved gate region; other site 1167634018846 putative PBP binding loops; other site 1167634018847 ABC-ATPase subunit interface; other site 1167634018848 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1167634018849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634018850 dimer interface [polypeptide binding]; other site 1167634018851 conserved gate region; other site 1167634018852 putative PBP binding loops; other site 1167634018853 ABC-ATPase subunit interface; other site 1167634018854 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1167634018855 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634018856 Walker A/P-loop; other site 1167634018857 ATP binding site [chemical binding]; other site 1167634018858 Q-loop/lid; other site 1167634018859 ABC transporter signature motif; other site 1167634018860 Walker B; other site 1167634018861 D-loop; other site 1167634018862 H-loop/switch region; other site 1167634018863 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1167634018864 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1167634018865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1167634018866 Walker A/P-loop; other site 1167634018867 ATP binding site [chemical binding]; other site 1167634018868 Q-loop/lid; other site 1167634018869 ABC transporter signature motif; other site 1167634018870 Walker B; other site 1167634018871 D-loop; other site 1167634018872 H-loop/switch region; other site 1167634018873 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1167634018874 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1167634018875 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1167634018876 Predicted acyl esterases [General function prediction only]; Region: COG2936 1167634018877 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1167634018878 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1167634018879 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1167634018880 trimer interface [polypeptide binding]; other site 1167634018881 eyelet of channel; other site 1167634018882 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1167634018883 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1167634018884 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1167634018885 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634018886 DNA-binding site [nucleotide binding]; DNA binding site 1167634018887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1167634018888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634018889 homodimer interface [polypeptide binding]; other site 1167634018890 catalytic residue [active] 1167634018891 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1167634018892 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1167634018893 OsmC-like protein; Region: OsmC; pfam02566 1167634018894 Rhabdovirus spike glycoprotein; Region: Rhabdo_glycop; pfam00974 1167634018895 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 1167634018896 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1167634018897 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1167634018898 metal binding site [ion binding]; metal-binding site 1167634018899 active site 1167634018900 I-site; other site 1167634018901 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1167634018902 dimanganese center [ion binding]; other site 1167634018903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634018904 Coenzyme A binding pocket [chemical binding]; other site 1167634018905 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1167634018906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1167634018907 sequence-specific DNA binding site [nucleotide binding]; other site 1167634018908 salt bridge; other site 1167634018909 Cupin domain; Region: Cupin_2; pfam07883 1167634018910 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1167634018911 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1167634018912 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1167634018913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634018914 dimer interface [polypeptide binding]; other site 1167634018915 conserved gate region; other site 1167634018916 putative PBP binding loops; other site 1167634018917 ABC-ATPase subunit interface; other site 1167634018918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634018919 dimer interface [polypeptide binding]; other site 1167634018920 conserved gate region; other site 1167634018921 putative PBP binding loops; other site 1167634018922 ABC-ATPase subunit interface; other site 1167634018923 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1167634018924 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1167634018925 substrate binding pocket [chemical binding]; other site 1167634018926 membrane-bound complex binding site; other site 1167634018927 hinge residues; other site 1167634018928 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1167634018929 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1167634018930 Walker A/P-loop; other site 1167634018931 ATP binding site [chemical binding]; other site 1167634018932 Q-loop/lid; other site 1167634018933 ABC transporter signature motif; other site 1167634018934 Walker B; other site 1167634018935 D-loop; other site 1167634018936 H-loop/switch region; other site 1167634018937 aldehyde dehydrogenase family 7 member; Region: PLN02315 1167634018938 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1167634018939 tetrameric interface [polypeptide binding]; other site 1167634018940 NAD binding site [chemical binding]; other site 1167634018941 catalytic residues [active] 1167634018942 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 1167634018943 substrate binding site [chemical binding]; other site 1167634018944 dimerization interface [polypeptide binding]; other site 1167634018945 active site 1167634018946 calcium binding site [ion binding]; other site 1167634018947 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1167634018948 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1167634018949 inhibitor site; inhibition site 1167634018950 active site 1167634018951 dimer interface [polypeptide binding]; other site 1167634018952 catalytic residue [active] 1167634018953 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1167634018954 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1167634018955 putative active site pocket [active] 1167634018956 putative metal binding site [ion binding]; other site 1167634018957 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1167634018958 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1167634018959 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634018960 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634018961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634018962 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1167634018963 putative dimerization interface [polypeptide binding]; other site 1167634018964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1167634018965 4Fe-4S binding domain; Region: Fer4; cl02805 1167634018966 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1167634018967 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1167634018968 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1167634018969 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1167634018970 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1167634018971 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 1167634018972 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1167634018973 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1167634018974 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1167634018975 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1167634018976 Low-spin heme binding site [chemical binding]; other site 1167634018977 Putative water exit pathway; other site 1167634018978 Binuclear center (active site) [active] 1167634018979 Putative proton exit pathway; other site 1167634018980 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 1167634018981 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1167634018982 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1167634018983 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1167634018984 inhibitor-cofactor binding pocket; inhibition site 1167634018985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1167634018986 catalytic residue [active] 1167634018987 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 1167634018988 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1167634018989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1167634018990 catalytic residue [active] 1167634018991 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1167634018992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634018993 S-adenosylmethionine binding site [chemical binding]; other site 1167634018994 AAA domain; Region: AAA_26; pfam13500 1167634018995 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1167634018996 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634018997 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1167634018998 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1167634018999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634019000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1167634019001 isocitrate lyase; Provisional; Region: PRK15063 1167634019002 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1167634019003 tetramer interface [polypeptide binding]; other site 1167634019004 active site 1167634019005 Mg2+/Mn2+ binding site [ion binding]; other site 1167634019006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1167634019007 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1167634019008 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1167634019009 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1167634019010 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1167634019011 transcriptional activator TtdR; Provisional; Region: PRK09801 1167634019012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634019013 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1167634019014 putative effector binding pocket; other site 1167634019015 putative dimerization interface [polypeptide binding]; other site 1167634019016 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1167634019017 tartrate dehydrogenase; Region: TTC; TIGR02089 1167634019018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634019019 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1167634019020 putative substrate translocation pore; other site 1167634019021 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1167634019022 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1167634019023 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1167634019024 GIY-YIG motif/motif A; other site 1167634019025 active site 1167634019026 catalytic site [active] 1167634019027 putative DNA binding site [nucleotide binding]; other site 1167634019028 metal binding site [ion binding]; metal-binding site 1167634019029 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1167634019030 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1167634019031 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1167634019032 beta-hexosaminidase; Provisional; Region: PRK05337 1167634019033 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1167634019034 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1167634019035 active site 1167634019036 hydrophilic channel; other site 1167634019037 dimerization interface [polypeptide binding]; other site 1167634019038 catalytic residues [active] 1167634019039 active site lid [active] 1167634019040 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1167634019041 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1167634019042 Protein export membrane protein; Region: SecD_SecF; cl14618 1167634019043 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1167634019044 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1167634019045 HlyD family secretion protein; Region: HlyD_3; pfam13437 1167634019046 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1167634019047 DNA binding site [nucleotide binding] 1167634019048 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1167634019049 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1167634019050 nucleophile elbow; other site 1167634019051 Patatin phospholipase; Region: DUF3734; pfam12536 1167634019052 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1167634019053 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1167634019054 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1167634019055 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1167634019056 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1167634019057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634019058 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1167634019059 Walker A/P-loop; other site 1167634019060 ATP binding site [chemical binding]; other site 1167634019061 Q-loop/lid; other site 1167634019062 ABC transporter signature motif; other site 1167634019063 Walker B; other site 1167634019064 D-loop; other site 1167634019065 H-loop/switch region; other site 1167634019066 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1167634019067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634019068 dimer interface [polypeptide binding]; other site 1167634019069 conserved gate region; other site 1167634019070 putative PBP binding loops; other site 1167634019071 ABC-ATPase subunit interface; other site 1167634019072 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1167634019073 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1167634019074 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 1167634019075 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1167634019076 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1167634019077 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1167634019078 Predicted membrane protein [Function unknown]; Region: COG3766 1167634019079 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1167634019080 spermidine synthase; Provisional; Region: PRK03612 1167634019081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634019082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1167634019083 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1167634019084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1167634019085 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1167634019086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1167634019087 Walker A/P-loop; other site 1167634019088 ATP binding site [chemical binding]; other site 1167634019089 Q-loop/lid; other site 1167634019090 ABC transporter signature motif; other site 1167634019091 Walker B; other site 1167634019092 D-loop; other site 1167634019093 H-loop/switch region; other site 1167634019094 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634019095 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1167634019096 TM-ABC transporter signature motif; other site 1167634019097 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1167634019098 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1167634019099 zinc binding site [ion binding]; other site 1167634019100 putative ligand binding site [chemical binding]; other site 1167634019101 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1167634019102 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1167634019103 active site 1167634019104 catalytic tetrad [active] 1167634019105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1167634019106 malonyl-CoA synthase; Validated; Region: PRK07514 1167634019107 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 1167634019108 acyl-activating enzyme (AAE) consensus motif; other site 1167634019109 active site 1167634019110 AMP binding site [chemical binding]; other site 1167634019111 CoA binding site [chemical binding]; other site 1167634019112 enoyl-CoA hydratase; Provisional; Region: PRK06127 1167634019113 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1167634019114 substrate binding site [chemical binding]; other site 1167634019115 oxyanion hole (OAH) forming residues; other site 1167634019116 trimer interface [polypeptide binding]; other site 1167634019117 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 1167634019118 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1167634019119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1167634019120 DNA-binding site [nucleotide binding]; DNA binding site 1167634019121 FCD domain; Region: FCD; pfam07729 1167634019122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1167634019123 beta-ketothiolase; Provisional; Region: PRK09051 1167634019124 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1167634019125 dimer interface [polypeptide binding]; other site 1167634019126 active site 1167634019127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634019128 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634019129 active site 1167634019130 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1167634019131 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1167634019132 active site 1167634019133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634019134 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1167634019135 dimerization interface [polypeptide binding]; other site 1167634019136 substrate binding pocket [chemical binding]; other site 1167634019137 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1167634019138 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1167634019139 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1167634019140 active site 1167634019141 catalytic site [active] 1167634019142 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1167634019143 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1167634019144 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1167634019145 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1167634019146 putative ligand binding site [chemical binding]; other site 1167634019147 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1167634019148 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1167634019149 Walker A/P-loop; other site 1167634019150 ATP binding site [chemical binding]; other site 1167634019151 Q-loop/lid; other site 1167634019152 ABC transporter signature motif; other site 1167634019153 Walker B; other site 1167634019154 D-loop; other site 1167634019155 H-loop/switch region; other site 1167634019156 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1167634019157 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1167634019158 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1167634019159 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1167634019160 TM-ABC transporter signature motif; other site 1167634019161 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1167634019162 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1167634019163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1167634019164 NAD(P) binding site [chemical binding]; other site 1167634019165 active site 1167634019166 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1167634019167 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1167634019168 DNA binding site [nucleotide binding] 1167634019169 domain linker motif; other site 1167634019170 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 1167634019171 putative dimerization interface [polypeptide binding]; other site 1167634019172 putative ligand binding site [chemical binding]; other site 1167634019173 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1167634019174 hexamer interface [polypeptide binding]; other site 1167634019175 active site 2 [active] 1167634019176 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1167634019177 dimer interface [polypeptide binding]; other site 1167634019178 hexamer interface [polypeptide binding]; other site 1167634019179 active site 2 [active] 1167634019180 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1167634019181 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1167634019182 Walker A/P-loop; other site 1167634019183 ATP binding site [chemical binding]; other site 1167634019184 Q-loop/lid; other site 1167634019185 ABC transporter signature motif; other site 1167634019186 Walker B; other site 1167634019187 D-loop; other site 1167634019188 H-loop/switch region; other site 1167634019189 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1167634019190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1167634019191 dimer interface [polypeptide binding]; other site 1167634019192 conserved gate region; other site 1167634019193 putative PBP binding loops; other site 1167634019194 ABC-ATPase subunit interface; other site 1167634019195 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1167634019196 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1167634019197 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1167634019198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1167634019199 S-adenosylmethionine binding site [chemical binding]; other site 1167634019200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634019201 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1167634019202 putative substrate translocation pore; other site 1167634019203 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1167634019204 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1167634019205 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1167634019206 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 1167634019207 putative ligand binding site [chemical binding]; other site 1167634019208 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1167634019209 TM-ABC transporter signature motif; other site 1167634019210 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1167634019211 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1167634019212 TM-ABC transporter signature motif; other site 1167634019213 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1167634019214 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1167634019215 Walker A/P-loop; other site 1167634019216 ATP binding site [chemical binding]; other site 1167634019217 Q-loop/lid; other site 1167634019218 ABC transporter signature motif; other site 1167634019219 Walker B; other site 1167634019220 D-loop; other site 1167634019221 H-loop/switch region; other site 1167634019222 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1167634019223 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1167634019224 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1167634019225 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1167634019226 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1167634019227 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1167634019228 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1167634019229 tetramer interface [polypeptide binding]; other site 1167634019230 active site 1167634019231 Mg2+/Mn2+ binding site [ion binding]; other site 1167634019232 Hemerythrin-like domain; Region: Hr-like; cd12108 1167634019233 Fe binding site [ion binding]; other site 1167634019234 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1167634019235 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1167634019236 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1167634019237 bacterial (prokaryotic) histone like domain; Region: BHL; smart00411 1167634019238 IHF dimer interface [polypeptide binding]; other site 1167634019239 IHF - DNA interface [nucleotide binding]; other site 1167634019240 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1167634019241 MarR family; Region: MarR; pfam01047 1167634019242 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1167634019243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634019244 putative substrate translocation pore; other site 1167634019245 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1167634019246 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1167634019247 HIGH motif; other site 1167634019248 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1167634019249 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1167634019250 active site 1167634019251 KMSKS motif; other site 1167634019252 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1167634019253 tRNA binding surface [nucleotide binding]; other site 1167634019254 Lipopolysaccharide-assembly; Region: LptE; cl01125 1167634019255 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1167634019256 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1167634019257 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1167634019258 putative catalytic cysteine [active] 1167634019259 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1167634019260 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1167634019261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1167634019262 Coenzyme A binding pocket [chemical binding]; other site 1167634019263 amidase; Provisional; Region: PRK07487 1167634019264 Amidase; Region: Amidase; cl11426 1167634019265 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1167634019266 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634019267 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1167634019268 dimerization interface [polypeptide binding]; other site 1167634019269 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1167634019270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1167634019271 putative substrate translocation pore; other site 1167634019272 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 1167634019273 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1167634019274 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1167634019275 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1167634019276 hypothetical protein; Provisional; Region: PRK01842 1167634019277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1167634019278 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1167634019279 dimerization interface [polypeptide binding]; other site 1167634019280 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1167634019281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1167634019282 motif II; other site 1167634019283 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1167634019284 intersubunit interface [polypeptide binding]; other site 1167634019285 active site 1167634019286 Zn2+ binding site [ion binding]; other site