-- dump date   	20140618_184753
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
349163000001	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
349163000002	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
349163000003	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
349163000004	active site
349163000005	LssY C-terminus; Region: LssY_C; pfam14067
349163000006	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
349163000007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163000008	active site
349163000009	phosphorylation site [posttranslational modification]
349163000010	intermolecular recognition site; other site
349163000011	dimerization interface [polypeptide binding]; other site
349163000012	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163000013	DNA binding site [nucleotide binding]
349163000014	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
349163000015	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349163000016	dimerization interface [polypeptide binding]; other site
349163000017	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349163000018	dimer interface [polypeptide binding]; other site
349163000019	phosphorylation site [posttranslational modification]
349163000020	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163000021	ATP binding site [chemical binding]; other site
349163000022	Mg2+ binding site [ion binding]; other site
349163000023	G-X-G motif; other site
349163000024	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
349163000025	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349163000026	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163000027	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163000028	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349163000029	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
349163000030	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
349163000031	Integrase core domain; Region: rve; pfam00665
349163000032	Helix-turn-helix domain; Region: HTH_28; pfam13518
349163000033	Winged helix-turn helix; Region: HTH_29; pfam13551
349163000034	Winged helix-turn helix; Region: HTH_33; pfam13592
349163000035	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349163000036	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
349163000037	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163000038	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349163000039	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163000040	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349163000041	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163000042	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163000043	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
349163000044	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349163000045	Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965
349163000046	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
349163000047	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163000048	MULE transposase domain; Region: MULE; pfam10551
349163000049	Transposase domain (DUF772); Region: DUF772; pfam05598
349163000050	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
349163000051	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
349163000052	active site
349163000053	Cupin domain; Region: Cupin_2; cl17218
349163000054	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
349163000055	mercuric reductase; Validated; Region: PRK06370
349163000056	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349163000057	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349163000058	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349163000059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
349163000060	Putative glucoamylase; Region: Glycoamylase; pfam10091
349163000061	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
349163000062	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
349163000063	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349163000064	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
349163000065	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
349163000066	glucose-1-dehydrogenase; Provisional; Region: PRK08936
349163000067	NAD binding site [chemical binding]; other site
349163000068	homodimer interface [polypeptide binding]; other site
349163000069	active site
349163000070	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349163000071	Putative glucoamylase; Region: Glycoamylase; pfam10091
349163000072	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
349163000073	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
349163000074	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
349163000075	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
349163000076	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349163000077	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349163000078	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
349163000079	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349163000080	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
349163000081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163000082	S-adenosylmethionine binding site [chemical binding]; other site
349163000083	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
349163000084	Domain of unknown function DUF20; Region: UPF0118; pfam01594
349163000085	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
349163000086	CsbD-like; Region: CsbD; pfam05532
349163000087	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349163000088	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163000089	non-specific DNA binding site [nucleotide binding]; other site
349163000090	salt bridge; other site
349163000091	sequence-specific DNA binding site [nucleotide binding]; other site
349163000092	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349163000093	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349163000094	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163000095	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163000096	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163000097	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349163000098	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163000099	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163000100	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349163000101	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163000102	DDE superfamily endonuclease; Region: DDE_5; pfam13546
349163000103	DDE superfamily endonuclease; Region: DDE_5; cl17874
349163000104	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
349163000105	Transposase [DNA replication, recombination, and repair]; Region: COG5421
349163000106	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
349163000107	transposase/IS protein; Provisional; Region: PRK09183
349163000108	IstB-like ATP binding protein; Region: IstB_IS21; pfam01695
349163000109	transposase; Validated; Region: PRK08181
349163000110	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000111	Walker A motif; other site
349163000112	ATP binding site [chemical binding]; other site
349163000113	Walker B motif; other site
349163000114	Integrase core domain; Region: rve; pfam00665
349163000115	CheB methylesterase; Region: CheB_methylest; pfam01339
349163000116	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
349163000117	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
349163000118	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
349163000119	PAS domain; Region: PAS_10; pfam13596
349163000120	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349163000121	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349163000122	dimer interface [polypeptide binding]; other site
349163000123	phosphorylation site [posttranslational modification]
349163000124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163000125	ATP binding site [chemical binding]; other site
349163000126	Mg2+ binding site [ion binding]; other site
349163000127	G-X-G motif; other site
349163000128	Response regulator receiver domain; Region: Response_reg; pfam00072
349163000129	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163000130	active site
349163000131	phosphorylation site [posttranslational modification]
349163000132	intermolecular recognition site; other site
349163000133	dimerization interface [polypeptide binding]; other site
349163000134	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
349163000135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163000136	active site
349163000137	phosphorylation site [posttranslational modification]
349163000138	intermolecular recognition site; other site
349163000139	dimerization interface [polypeptide binding]; other site
349163000140	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349163000141	DNA binding residues [nucleotide binding]
349163000142	dimerization interface [polypeptide binding]; other site
349163000143	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163000144	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349163000145	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163000146	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349163000147	DNA-binding site [nucleotide binding]; DNA binding site
349163000148	Transcriptional regulators [Transcription]; Region: GntR; COG1802
349163000149	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
349163000150	DNA-binding site [nucleotide binding]; DNA binding site
349163000151	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163000152	MULE transposase domain; Region: MULE; pfam10551
349163000153	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
349163000154	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
349163000155	Integrase core domain; Region: rve; pfam00665
349163000156	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
349163000157	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
349163000158	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
349163000159	oligomeric interface; other site
349163000160	putative active site [active]
349163000161	homodimer interface [polypeptide binding]; other site
349163000162	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
349163000163	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
349163000164	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163000165	MULE transposase domain; Region: MULE; pfam10551
349163000166	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349163000167	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163000168	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
349163000169	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349163000170	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349163000171	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163000172	non-specific DNA binding site [nucleotide binding]; other site
349163000173	salt bridge; other site
349163000174	sequence-specific DNA binding site [nucleotide binding]; other site
349163000175	CsbD-like; Region: CsbD; pfam05532
349163000176	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
349163000177	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
349163000178	Domain of unknown function DUF20; Region: UPF0118; pfam01594
349163000179	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
349163000180	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
349163000181	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
349163000182	DDE superfamily endonuclease; Region: DDE_5; pfam13546
349163000183	DDE superfamily endonuclease; Region: DDE_5; cl17874
349163000184	Transposase [DNA replication, recombination, and repair]; Region: COG5421
349163000185	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
349163000186	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
349163000187	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
349163000188	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349163000189	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
349163000190	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
349163000191	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349163000192	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163000193	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163000194	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
349163000195	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349163000196	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349163000197	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
349163000198	Integrase core domain; Region: rve; pfam00665
349163000199	Transposase domain (DUF772); Region: DUF772; pfam05598
349163000200	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163000201	MULE transposase domain; Region: MULE; pfam10551
349163000202	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349163000203	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
349163000204	ligand binding site [chemical binding]; other site
349163000205	flexible hinge region; other site
349163000206	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
349163000207	putative switch regulator; other site
349163000208	non-specific DNA interactions [nucleotide binding]; other site
349163000209	DNA binding site [nucleotide binding]
349163000210	sequence specific DNA binding site [nucleotide binding]; other site
349163000211	putative cAMP binding site [chemical binding]; other site
349163000212	Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965
349163000213	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163000214	S-adenosylmethionine binding site [chemical binding]; other site
349163000215	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
349163000216	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163000217	MULE transposase domain; Region: MULE; pfam10551
349163000218	Integrase core domain; Region: rve; pfam00665
349163000219	transposase; Validated; Region: PRK08181
349163000220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000221	Walker A motif; other site
349163000222	ATP binding site [chemical binding]; other site
349163000223	Walker B motif; other site
349163000224	Transposase [DNA replication, recombination, and repair]; Region: COG5421
349163000225	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
349163000226	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
349163000227	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
349163000228	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
349163000229	AAA domain; Region: AAA_30; pfam13604
349163000230	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349163000231	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349163000232	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
349163000233	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
349163000234	transposase/IS protein; Provisional; Region: PRK09183
349163000235	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000236	Walker A motif; other site
349163000237	ATP binding site [chemical binding]; other site
349163000238	Walker B motif; other site
349163000239	arginine finger; other site
349163000240	Helix-turn-helix domain; Region: HTH_38; pfam13936
349163000241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349163000242	Integrase core domain; Region: rve; pfam00665
349163000243	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
349163000244	metal-binding site [ion binding]
349163000245	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349163000246	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
349163000247	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
349163000248	DNA binding residues [nucleotide binding]
349163000249	dimer interface [polypeptide binding]; other site
349163000250	putative metal binding site [ion binding]; other site
349163000251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163000252	putative substrate translocation pore; other site
349163000253	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349163000254	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
349163000255	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349163000256	dimerization interface [polypeptide binding]; other site
349163000257	putative DNA binding site [nucleotide binding]; other site
349163000258	putative Zn2+ binding site [ion binding]; other site
349163000259	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349163000260	active site residue [active]
349163000261	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163000262	non-specific DNA binding site [nucleotide binding]; other site
349163000263	salt bridge; other site
349163000264	sequence-specific DNA binding site [nucleotide binding]; other site
349163000265	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
349163000266	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
349163000267	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163000268	MULE transposase domain; Region: MULE; pfam10551
349163000269	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349163000270	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
349163000271	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
349163000272	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163000273	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163000274	metal binding site [ion binding]; metal-binding site
349163000275	active site
349163000276	I-site; other site
349163000277	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163000278	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
349163000279	Transposase; Region: DDE_Tnp_ISL3; pfam01610
349163000280	Resolvase, N terminal domain; Region: Resolvase; smart00857
349163000281	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349163000282	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
349163000283	DNA-binding interface [nucleotide binding]; DNA binding site
349163000284	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349163000285	dimerization interface [polypeptide binding]; other site
349163000286	putative DNA binding site [nucleotide binding]; other site
349163000287	putative Zn2+ binding site [ion binding]; other site
349163000288	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349163000289	active site residue [active]
349163000290	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
349163000291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163000292	putative substrate translocation pore; other site
349163000293	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349163000294	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
349163000295	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349163000296	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
349163000297	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
349163000298	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
349163000299	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
349163000300	Int/Topo IB signature motif; other site
349163000301	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
349163000302	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349163000303	active site
349163000304	DNA binding site [nucleotide binding]
349163000305	Int/Topo IB signature motif; other site
349163000306	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
349163000307	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
349163000308	Int/Topo IB signature motif; other site
349163000309	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
349163000310	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
349163000311	putative active site [active]
349163000312	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
349163000313	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349163000314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
349163000315	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
349163000316	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
349163000317	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
349163000318	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000319	Walker A motif; other site
349163000320	ATP binding site [chemical binding]; other site
349163000321	Helicase; Region: Helicase_RecD; pfam05127
349163000322	Family description; Region: UvrD_C_2; pfam13538
349163000323	Replication protein C N-terminal domain; Region: RP-C; pfam03428
349163000324	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
349163000325	plasmid partitioning protein RepB; Provisional; Region: PRK13866
349163000326	ParB-like nuclease domain; Region: ParB; smart00470
349163000327	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
349163000328	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349163000329	P-loop; other site
349163000330	Magnesium ion binding site [ion binding]; other site
349163000331	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349163000332	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
349163000333	DNA binding site [nucleotide binding]
349163000334	dimer interface [polypeptide binding]; other site
349163000335	active site
349163000336	Int/Topo IB signature motif; other site
349163000337	PIN domain; Region: PIN_3; pfam13470
349163000338	DNA binding domain, excisionase family; Region: excise; TIGR01764
349163000339	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
349163000340	Beta-lactamase; Region: Beta-lactamase; pfam00144
349163000341	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
349163000342	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
349163000343	Integrase core domain; Region: rve; pfam00665
349163000344	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
349163000345	molybdopterin cofactor binding site; other site
349163000346	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
349163000347	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
349163000348	molybdopterin cofactor binding site; other site
349163000349	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
349163000350	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
349163000351	active site
349163000352	SAM binding site [chemical binding]; other site
349163000353	homodimer interface [polypeptide binding]; other site
349163000354	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
349163000355	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163000356	Uncharacterized conserved protein [Function unknown]; Region: COG0398
349163000357	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
349163000358	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
349163000359	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
349163000360	putative active site [active]
349163000361	putative PHP Thumb interface [polypeptide binding]; other site
349163000362	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
349163000363	generic binding surface I; other site
349163000364	generic binding surface II; other site
349163000365	DNA Polymerase Y-family; Region: PolY_like; cd03468
349163000366	active site
349163000367	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
349163000368	DNA binding site [nucleotide binding]
349163000369	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
349163000370	Part of AAA domain; Region: AAA_19; pfam13245
349163000371	Family description; Region: UvrD_C_2; pfam13538
349163000372	Uncharacterized conserved protein [Function unknown]; Region: COG2135
349163000373	Probable transposase; Region: OrfB_IS605; pfam01385
349163000374	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
349163000375	Integrase core domain; Region: rve; pfam00665
349163000376	transposase; Validated; Region: PRK08181
349163000377	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000378	Walker A motif; other site
349163000379	ATP binding site [chemical binding]; other site
349163000380	Walker B motif; other site
349163000381	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
349163000382	Probable transposase; Region: OrfB_IS605; pfam01385
349163000383	Transposase IS200 like; Region: Y1_Tnp; pfam01797
349163000384	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349163000385	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349163000386	HlyD family secretion protein; Region: HlyD_3; pfam13437
349163000387	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349163000388	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
349163000389	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349163000390	Walker A/P-loop; other site
349163000391	ATP binding site [chemical binding]; other site
349163000392	Q-loop/lid; other site
349163000393	ABC transporter signature motif; other site
349163000394	Walker B; other site
349163000395	D-loop; other site
349163000396	H-loop/switch region; other site
349163000397	replication initiation protein RepC; Provisional; Region: PRK13824
349163000398	Replication protein C N-terminal domain; Region: RP-C; pfam03428
349163000399	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
349163000400	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163000401	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163000402	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
349163000403	putative dimerization interface [polypeptide binding]; other site
349163000404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163000405	putative substrate translocation pore; other site
349163000406	Nitronate monooxygenase; Region: NMO; pfam03060
349163000407	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
349163000408	FMN binding site [chemical binding]; other site
349163000409	substrate binding site [chemical binding]; other site
349163000410	putative catalytic residue [active]
349163000411	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
349163000412	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
349163000413	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
349163000414	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
349163000415	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
349163000416	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
349163000417	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
349163000418	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
349163000419	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
349163000420	CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI; Region: cas1_ECOLI; TIGR03638
349163000421	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
349163000422	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
349163000423	DNA binding residues [nucleotide binding]
349163000424	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
349163000425	catalytic residues [active]
349163000426	catalytic nucleophile [active]
349163000427	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
349163000428	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
349163000429	Probable transposase; Region: OrfB_IS605; pfam01385
349163000430	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
349163000431	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
349163000432	RuvA N terminal domain; Region: RuvA_N; pfam01330
349163000433	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
349163000434	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000435	Walker A motif; other site
349163000436	ATP binding site [chemical binding]; other site
349163000437	Walker B motif; other site
349163000438	arginine finger; other site
349163000439	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
349163000440	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
349163000441	Uncharacterized conserved protein [Function unknown]; Region: COG2353
349163000442	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
349163000443	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
349163000444	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
349163000445	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163000446	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163000447	metal binding site [ion binding]; metal-binding site
349163000448	active site
349163000449	I-site; other site
349163000450	LysE type translocator; Region: LysE; cl00565
349163000451	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
349163000452	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349163000453	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
349163000454	Presynaptic Site I dimer interface [polypeptide binding]; other site
349163000455	catalytic residues [active]
349163000456	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
349163000457	Synaptic Flat tetramer interface [polypeptide binding]; other site
349163000458	Synaptic Site I dimer interface [polypeptide binding]; other site
349163000459	DNA binding site [nucleotide binding]
349163000460	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
349163000461	DNA-binding interface [nucleotide binding]; DNA binding site
349163000462	Transposase; Region: HTH_Tnp_1; cl17663
349163000463	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
349163000464	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349163000465	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
349163000466	putative active site [active]
349163000467	putative metal binding site [ion binding]; other site
349163000468	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349163000469	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
349163000470	active site
349163000471	metal binding site [ion binding]; metal-binding site
349163000472	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
349163000473	Transcriptional regulator [Transcription]; Region: IclR; COG1414
349163000474	Bacterial transcriptional regulator; Region: IclR; pfam01614
349163000475	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
349163000476	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349163000477	Walker A/P-loop; other site
349163000478	ATP binding site [chemical binding]; other site
349163000479	Q-loop/lid; other site
349163000480	ABC transporter signature motif; other site
349163000481	Walker B; other site
349163000482	D-loop; other site
349163000483	H-loop/switch region; other site
349163000484	acetylornithine deacetylase; Provisional; Region: PRK06837
349163000485	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
349163000486	metal binding site [ion binding]; metal-binding site
349163000487	dimer interface [polypeptide binding]; other site
349163000488	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
349163000489	nudix motif; other site
349163000490	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
349163000491	Na binding site [ion binding]; other site
349163000492	Restriction endonuclease; Region: Mrr_cat; pfam04471
349163000493	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163000494	non-specific DNA binding site [nucleotide binding]; other site
349163000495	salt bridge; other site
349163000496	sequence-specific DNA binding site [nucleotide binding]; other site
349163000497	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
349163000498	UDP-GlcNAc-dependent glycosyltransferase; Provisional; Region: PTZ00210
349163000499	Fic family protein [Function unknown]; Region: COG3177
349163000500	Fic/DOC family; Region: Fic; pfam02661
349163000501	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
349163000502	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
349163000503	putative active site [active]
349163000504	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
349163000505	His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978
349163000506	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163000507	FeS/SAM binding site; other site
349163000508	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
349163000509	His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977
349163000510	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163000511	FeS/SAM binding site; other site
349163000512	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000513	Walker A motif; other site
349163000514	ATP binding site [chemical binding]; other site
349163000515	Walker B motif; other site
349163000516	arginine finger; other site
349163000517	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
349163000518	RES domain; Region: RES; cl02411
349163000519	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
349163000520	DNA binding residues [nucleotide binding]
349163000521	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163000522	non-specific DNA binding site [nucleotide binding]; other site
349163000523	salt bridge; other site
349163000524	sequence-specific DNA binding site [nucleotide binding]; other site
349163000525	HipA N-terminal domain; Region: Couple_hipA; pfam13657
349163000526	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
349163000527	HipA-like N-terminal domain; Region: HipA_N; pfam07805
349163000528	HipA-like C-terminal domain; Region: HipA_C; pfam07804
349163000529	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
349163000530	putative phosphoketolase; Provisional; Region: PRK05261
349163000531	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
349163000532	TPP-binding site; other site
349163000533	XFP C-terminal domain; Region: XFP_C; pfam09363
349163000534	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349163000535	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349163000536	Transposase [DNA replication, recombination, and repair]; Region: COG5421
349163000537	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
349163000538	DNA-binding interface [nucleotide binding]; DNA binding site
349163000539	pyruvate dehydrogenase; Provisional; Region: PRK09124
349163000540	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
349163000541	PYR/PP interface [polypeptide binding]; other site
349163000542	dimer interface [polypeptide binding]; other site
349163000543	TPP binding site [chemical binding]; other site
349163000544	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349163000545	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
349163000546	TPP-binding site [chemical binding]; other site
349163000547	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
349163000548	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
349163000549	active site
349163000550	FMN binding site [chemical binding]; other site
349163000551	substrate binding site [chemical binding]; other site
349163000552	3Fe-4S cluster binding site [ion binding]; other site
349163000553	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
349163000554	Transposase [DNA replication, recombination, and repair]; Region: COG5421
349163000555	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163000556	MULE transposase domain; Region: MULE; pfam10551
349163000557	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
349163000558	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349163000559	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
349163000560	catalytic residues [active]
349163000561	catalytic nucleophile [active]
349163000562	Recombinase; Region: Recombinase; pfam07508
349163000563	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
349163000564	DNA binding residues [nucleotide binding]
349163000565	HTH-like domain; Region: HTH_21; pfam13276
349163000566	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
349163000567	Integrase core domain; Region: rve; pfam00665
349163000568	Integrase core domain; Region: rve_3; pfam13683
349163000569	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349163000570	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163000571	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163000572	Transposase; Region: HTH_Tnp_1; pfam01527
349163000573	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349163000574	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
349163000575	NADP binding site [chemical binding]; other site
349163000576	putative substrate binding site [chemical binding]; other site
349163000577	active site
349163000578	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
349163000579	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
349163000580	DNA binding residues [nucleotide binding]
349163000581	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
349163000582	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349163000583	Integrase core domain; Region: rve; pfam00665
349163000584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349163000585	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
349163000586	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
349163000587	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000588	Walker A motif; other site
349163000589	ATP binding site [chemical binding]; other site
349163000590	Walker B motif; other site
349163000591	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
349163000592	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
349163000593	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349163000594	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349163000595	Transcriptional regulators [Transcription]; Region: GntR; COG1802
349163000596	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349163000597	DNA-binding site [nucleotide binding]; DNA binding site
349163000598	FCD domain; Region: FCD; pfam07729
349163000599	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
349163000600	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
349163000601	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
349163000602	metabolite-proton symporter; Region: 2A0106; TIGR00883
349163000603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163000604	putative substrate translocation pore; other site
349163000605	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349163000606	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
349163000607	classical (c) SDRs; Region: SDR_c; cd05233
349163000608	NAD(P) binding site [chemical binding]; other site
349163000609	active site
349163000610	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
349163000611	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
349163000612	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
349163000613	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
349163000614	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
349163000615	NIPSNAP; Region: NIPSNAP; pfam07978
349163000616	Domain of unknown function DUF302; Region: DUF302; cl01364
349163000617	Transposase; Region: HTH_Tnp_1; pfam01527
349163000618	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
349163000619	HTH-like domain; Region: HTH_21; pfam13276
349163000620	Integrase core domain; Region: rve; pfam00665
349163000621	Integrase core domain; Region: rve_3; pfam13683
349163000622	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163000623	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349163000624	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
349163000625	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
349163000626	homodimer interface [polypeptide binding]; other site
349163000627	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163000628	catalytic residue [active]
349163000629	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
349163000630	Sodium Bile acid symporter family; Region: SBF; cl17470
349163000631	enoyl-CoA hydratase; Provisional; Region: PRK06144
349163000632	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349163000633	substrate binding site [chemical binding]; other site
349163000634	oxyanion hole (OAH) forming residues; other site
349163000635	trimer interface [polypeptide binding]; other site
349163000636	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
349163000637	CoA-transferase family III; Region: CoA_transf_3; pfam02515
349163000638	transcriptional regulator NanR; Provisional; Region: PRK03837
349163000639	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349163000640	DNA-binding site [nucleotide binding]; DNA binding site
349163000641	FCD domain; Region: FCD; pfam07729
349163000642	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
349163000643	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349163000644	DDE superfamily endonuclease; Region: DDE_4; cl17710
349163000645	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
349163000646	SnoaL-like domain; Region: SnoaL_3; pfam13474
349163000647	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163000648	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163000649	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349163000650	putative effector binding pocket; other site
349163000651	dimerization interface [polypeptide binding]; other site
349163000652	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
349163000653	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349163000654	putative NAD(P) binding site [chemical binding]; other site
349163000655	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
349163000656	DNA binding site [nucleotide binding]
349163000657	dimer interface [polypeptide binding]; other site
349163000658	active site
349163000659	Int/Topo IB signature motif; other site
349163000660	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
349163000661	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
349163000662	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
349163000663	active site
349163000664	AAA domain; Region: AAA_28; pfam13521
349163000665	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163000666	ATP binding site [chemical binding]; other site
349163000667	Walker A/P-loop; other site
349163000668	ABC transporter signature motif; other site
349163000669	Walker B; other site
349163000670	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349163000671	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349163000672	P-loop; other site
349163000673	Magnesium ion binding site [ion binding]; other site
349163000674	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
349163000675	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
349163000676	AAA domain; Region: AAA_12; pfam13087
349163000677	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
349163000678	HipA N-terminal domain; Region: Couple_hipA; cl11853
349163000679	HipA-like N-terminal domain; Region: HipA_N; pfam07805
349163000680	HipA-like C-terminal domain; Region: HipA_C; pfam07804
349163000681	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
349163000682	active site
349163000683	catalytic residues [active]
349163000684	DNA binding site [nucleotide binding]
349163000685	Int/Topo IB signature motif; other site
349163000686	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
349163000687	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163000688	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349163000689	non-specific DNA binding site [nucleotide binding]; other site
349163000690	salt bridge; other site
349163000691	sequence-specific DNA binding site [nucleotide binding]; other site
349163000692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
349163000693	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
349163000694	Protein of unknown function (DUF805); Region: DUF805; pfam05656
349163000695	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
349163000696	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
349163000697	Walker A/P-loop; other site
349163000698	ATP binding site [chemical binding]; other site
349163000699	Q-loop/lid; other site
349163000700	ABC transporter signature motif; other site
349163000701	Walker B; other site
349163000702	D-loop; other site
349163000703	H-loop/switch region; other site
349163000704	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163000705	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
349163000706	Walker A/P-loop; other site
349163000707	ATP binding site [chemical binding]; other site
349163000708	Q-loop/lid; other site
349163000709	ABC transporter signature motif; other site
349163000710	Walker B; other site
349163000711	D-loop; other site
349163000712	H-loop/switch region; other site
349163000713	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
349163000714	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
349163000715	TM-ABC transporter signature motif; other site
349163000716	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
349163000717	TM-ABC transporter signature motif; other site
349163000718	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349163000719	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
349163000720	putative ligand binding site [chemical binding]; other site
349163000721	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
349163000722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163000723	S-adenosylmethionine binding site [chemical binding]; other site
349163000724	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
349163000725	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
349163000726	Cl- selectivity filter; other site
349163000727	Cl- binding residues [ion binding]; other site
349163000728	pore gating glutamate residue; other site
349163000729	dimer interface [polypeptide binding]; other site
349163000730	FOG: CBS domain [General function prediction only]; Region: COG0517
349163000731	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
349163000732	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163000733	putative substrate translocation pore; other site
349163000734	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349163000735	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
349163000736	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349163000737	dimerization interface [polypeptide binding]; other site
349163000738	putative DNA binding site [nucleotide binding]; other site
349163000739	putative Zn2+ binding site [ion binding]; other site
349163000740	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349163000741	active site residue [active]
349163000742	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
349163000743	Putative transposase; Region: Y2_Tnp; pfam04986
349163000744	integron integrase; Region: integrase_gron; TIGR02249
349163000745	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
349163000746	Int/Topo IB signature motif; other site
349163000747	Cytochrome c2 [Energy production and conversion]; Region: COG3474
349163000748	SCP-2 sterol transfer family; Region: SCP2; cl01225
349163000749	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
349163000750	Peptidase family U32; Region: Peptidase_U32; pfam01136
349163000751	putative protease; Provisional; Region: PRK15447
349163000752	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
349163000753	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.   The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153
349163000754	homotrimer interaction site [polypeptide binding]; other site
349163000755	putative active site [active]
349163000756	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
349163000757	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
349163000758	active site
349163000759	multimer interface [polypeptide binding]; other site
349163000760	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
349163000761	predicted active site [active]
349163000762	catalytic triad [active]
349163000763	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
349163000764	Class III ribonucleotide reductase; Region: RNR_III; cd01675
349163000765	effector binding site; other site
349163000766	active site
349163000767	Zn binding site [ion binding]; other site
349163000768	glycine loop; other site
349163000769	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
349163000770	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163000771	FeS/SAM binding site; other site
349163000772	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
349163000773	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349163000774	Transposase [DNA replication, recombination, and repair]; Region: COG5433
349163000775	Transposase [DNA replication, recombination, and repair]; Region: COG5433
349163000776	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
349163000777	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349163000778	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349163000779	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
349163000780	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
349163000781	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000782	Walker A motif; other site
349163000783	ATP binding site [chemical binding]; other site
349163000784	Walker B motif; other site
349163000785	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349163000786	Integrase core domain; Region: rve; pfam00665
349163000787	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349163000788	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
349163000789	Transposase; Region: DDE_Tnp_ISL3; pfam01610
349163000790	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
349163000791	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
349163000792	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349163000793	Soluble P-type ATPase [General function prediction only]; Region: COG4087
349163000794	K+-transporting ATPase, c chain; Region: KdpC; cl00944
349163000795	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
349163000796	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
349163000797	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
349163000798	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
349163000799	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349163000800	dimer interface [polypeptide binding]; other site
349163000801	phosphorylation site [posttranslational modification]
349163000802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163000803	ATP binding site [chemical binding]; other site
349163000804	G-X-G motif; other site
349163000805	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349163000806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163000807	active site
349163000808	phosphorylation site [posttranslational modification]
349163000809	intermolecular recognition site; other site
349163000810	dimerization interface [polypeptide binding]; other site
349163000811	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163000812	DNA binding site [nucleotide binding]
349163000813	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
349163000814	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
349163000815	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
349163000816	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349163000817	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
349163000818	catalytic residues [active]
349163000819	catalytic nucleophile [active]
349163000820	Presynaptic Site I dimer interface [polypeptide binding]; other site
349163000821	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
349163000822	Synaptic Flat tetramer interface [polypeptide binding]; other site
349163000823	Synaptic Site I dimer interface [polypeptide binding]; other site
349163000824	DNA binding site [nucleotide binding]
349163000825	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349163000826	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
349163000827	catalytic residues [active]
349163000828	catalytic nucleophile [active]
349163000829	Presynaptic Site I dimer interface [polypeptide binding]; other site
349163000830	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
349163000831	Synaptic Flat tetramer interface [polypeptide binding]; other site
349163000832	Synaptic Site I dimer interface [polypeptide binding]; other site
349163000833	DNA binding site [nucleotide binding]
349163000834	Recombinase; Region: Recombinase; pfam07508
349163000835	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
349163000836	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
349163000837	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
349163000838	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
349163000839	Int/Topo IB signature motif; other site
349163000840	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
349163000841	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349163000842	active site
349163000843	DNA binding site [nucleotide binding]
349163000844	Int/Topo IB signature motif; other site
349163000845	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
349163000846	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349163000847	active site
349163000848	DNA binding site [nucleotide binding]
349163000849	Int/Topo IB signature motif; other site
349163000850	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
349163000851	Integrase core domain; Region: rve; pfam00665
349163000852	transposase; Validated; Region: PRK08181
349163000853	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000854	Walker A motif; other site
349163000855	ATP binding site [chemical binding]; other site
349163000856	Walker B motif; other site
349163000857	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
349163000858	putative active site [active]
349163000859	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
349163000860	Nuclease-related domain; Region: NERD; pfam08378
349163000861	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
349163000862	ParA-like protein; Provisional; Region: PHA02518
349163000863	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349163000864	P-loop; other site
349163000865	Magnesium ion binding site [ion binding]; other site
349163000866	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
349163000867	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163000868	non-specific DNA binding site [nucleotide binding]; other site
349163000869	salt bridge; other site
349163000870	sequence-specific DNA binding site [nucleotide binding]; other site
349163000871	replication initiation protein RepC; Provisional; Region: PRK13824
349163000872	Replication protein C N-terminal domain; Region: RP-C; pfam03428
349163000873	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
349163000874	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349163000875	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349163000876	catalytic residue [active]
349163000877	TrbC/VIRB2 family; Region: TrbC; pfam04956
349163000878	type IV secretion system protein VirB3; Provisional; Region: PRK13854
349163000879	type IV secretion system protein VirB4; Provisional; Region: PRK13853
349163000880	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
349163000881	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
349163000882	Type IV secretion system proteins; Region: T4SS; pfam07996
349163000883	type IV secretion system protein VirB6; Provisional; Region: PRK13852
349163000884	type IV secretion system protein VirB8; Provisional; Region: PRK13865
349163000885	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
349163000886	VirB7 interaction site; other site
349163000887	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
349163000888	type IV secretion system protein VirB11; Provisional; Region: PRK13851
349163000889	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
349163000890	Walker A motif; other site
349163000891	hexamer interface [polypeptide binding]; other site
349163000892	ATP binding site [chemical binding]; other site
349163000893	Walker B motif; other site
349163000894	conjugal transfer coupling protein TraG; Provisional; Region: PRK13822
349163000895	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349163000896	Walker A motif; other site
349163000897	ATP binding site [chemical binding]; other site
349163000898	Walker B motif; other site
349163000899	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349163000900	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
349163000901	AsnC family; Region: AsnC_trans_reg; pfam01037
349163000902	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
349163000903	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
349163000904	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349163000905	catalytic residue [active]
349163000906	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
349163000907	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
349163000908	metal binding site [ion binding]; metal-binding site
349163000909	putative dimer interface [polypeptide binding]; other site
349163000910	allantoate amidohydrolase; Reviewed; Region: PRK12890
349163000911	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
349163000912	active site
349163000913	metal binding site [ion binding]; metal-binding site
349163000914	dimer interface [polypeptide binding]; other site
349163000915	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
349163000916	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
349163000917	active site
349163000918	DNA binding site [nucleotide binding]
349163000919	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
349163000920	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
349163000921	Catalytic site [active]
349163000922	Uncharacterized conserved protein [Function unknown]; Region: COG2135
349163000923	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
349163000924	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
349163000925	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
349163000926	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
349163000927	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000928	Walker A motif; other site
349163000929	ATP binding site [chemical binding]; other site
349163000930	Helicase; Region: Helicase_RecD; pfam05127
349163000931	Family description; Region: UvrD_C_2; pfam13538
349163000932	Toprim domain; Region: Toprim_3; pfam13362
349163000933	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
349163000934	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
349163000935	AAA domain; Region: AAA_30; pfam13604
349163000936	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
349163000937	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
349163000938	CitB domain protein; Region: CitB; TIGR02484
349163000939	multiple promoter invertase; Provisional; Region: mpi; PRK13413
349163000940	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
349163000941	catalytic residues [active]
349163000942	catalytic nucleophile [active]
349163000943	Presynaptic Site I dimer interface [polypeptide binding]; other site
349163000944	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
349163000945	Synaptic Flat tetramer interface [polypeptide binding]; other site
349163000946	Synaptic Site I dimer interface [polypeptide binding]; other site
349163000947	DNA binding site [nucleotide binding]
349163000948	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
349163000949	DNA-binding interface [nucleotide binding]; DNA binding site
349163000950	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349163000951	Coenzyme A binding pocket [chemical binding]; other site
349163000952	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
349163000953	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
349163000954	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349163000955	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
349163000956	Walker A motif; other site
349163000957	ATP binding site [chemical binding]; other site
349163000958	Walker B motif; other site
349163000959	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
349163000961	Walker A motif; other site
349163000962	ATP binding site [chemical binding]; other site
349163000963	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349163000964	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
349163000965	catalytic residues [active]
349163000966	catalytic nucleophile [active]
349163000967	Presynaptic Site I dimer interface [polypeptide binding]; other site
349163000968	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
349163000969	Synaptic Flat tetramer interface [polypeptide binding]; other site
349163000970	Synaptic Site I dimer interface [polypeptide binding]; other site
349163000971	DNA binding site [nucleotide binding]
349163000972	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
349163000973	putative metal binding site [ion binding]; other site
349163000974	putative homodimer interface [polypeptide binding]; other site
349163000975	putative homotetramer interface [polypeptide binding]; other site
349163000976	putative homodimer-homodimer interface [polypeptide binding]; other site
349163000977	putative allosteric switch controlling residues; other site
349163000978	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
349163000979	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
349163000980	MgtC family; Region: MgtC; pfam02308
349163000981	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
349163000982	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
349163000983	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
349163000984	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
349163000985	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
349163000986	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163000987	MULE transposase domain; Region: MULE; pfam10551
349163000988	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349163000989	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
349163000990	catalytic residues [active]
349163000991	catalytic nucleophile [active]
349163000992	Presynaptic Site I dimer interface [polypeptide binding]; other site
349163000993	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
349163000994	Synaptic Flat tetramer interface [polypeptide binding]; other site
349163000995	Synaptic Site I dimer interface [polypeptide binding]; other site
349163000996	DNA binding site [nucleotide binding]
349163000997	stage V sporulation protein K; Region: spore_V_K; TIGR02881
349163000998	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163000999	Walker B motif; other site
349163001000	arginine finger; other site
349163001001	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
349163001002	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
349163001003	Probable transposase; Region: OrfB_IS605; pfam01385
349163001004	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
349163001005	replication initiation protein RepC; Provisional; Region: PRK13824
349163001006	Replication protein C N-terminal domain; Region: RP-C; pfam03428
349163001007	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
349163001008	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349163001009	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349163001010	P-loop; other site
349163001011	Magnesium ion binding site [ion binding]; other site
349163001012	N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016
349163001013	DNA binding site [nucleotide binding]
349163001014	EcoRII C terminal; Region: EcoRII-C; pfam09019
349163001015	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
349163001016	additional DNA contacts [nucleotide binding]; other site
349163001017	mismatch recognition site; other site
349163001018	active site
349163001019	zinc binding site [ion binding]; other site
349163001020	DNA intercalation site [nucleotide binding]; other site
349163001021	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163001022	salt bridge; other site
349163001023	non-specific DNA binding site [nucleotide binding]; other site
349163001024	sequence-specific DNA binding site [nucleotide binding]; other site
349163001025	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
349163001026	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
349163001027	cofactor binding site; other site
349163001028	DNA binding site [nucleotide binding]
349163001029	substrate interaction site [chemical binding]; other site
349163001030	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
349163001031	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
349163001032	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
349163001033	AAA domain; Region: AAA_30; pfam13604
349163001034	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
349163001035	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
349163001036	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
349163001037	DNA-binding interface [nucleotide binding]; DNA binding site
349163001038	Winged helix-turn helix; Region: HTH_29; pfam13551
349163001039	Integrase core domain; Region: rve; pfam00665
349163001040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349163001041	transposase/IS protein; Provisional; Region: PRK09183
349163001042	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163001043	Walker A motif; other site
349163001044	ATP binding site [chemical binding]; other site
349163001045	Walker B motif; other site
349163001046	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163001047	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349163001048	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163001049	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349163001050	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
349163001051	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
349163001052	PemK-like protein; Region: PemK; cl00995
349163001053	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
349163001054	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349163001055	Magnesium ion binding site [ion binding]; other site
349163001056	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
349163001057	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
349163001058	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
349163001059	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
349163001060	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349163001061	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
349163001062	catalytic residues [active]
349163001063	catalytic nucleophile [active]
349163001064	Presynaptic Site I dimer interface [polypeptide binding]; other site
349163001065	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
349163001066	Synaptic Flat tetramer interface [polypeptide binding]; other site
349163001067	Synaptic Site I dimer interface [polypeptide binding]; other site
349163001068	DNA binding site [nucleotide binding]
349163001069	phosphate:H+ symporter; Region: 2A0109; TIGR00887
349163001070	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163001071	putative substrate translocation pore; other site
349163001072	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
349163001073	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
349163001074	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
349163001075	Winged helix-turn helix; Region: HTH_29; pfam13551
349163001076	Helix-turn-helix domain; Region: HTH_28; pfam13518
349163001077	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163001078	MULE transposase domain; Region: MULE; pfam10551
349163001079	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163001080	MULE transposase domain; Region: MULE; pfam10551
349163001081	Transposase [DNA replication, recombination, and repair]; Region: COG5421
349163001082	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163001083	MULE transposase domain; Region: MULE; pfam10551
349163001084	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163001085	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
349163001086	AAA domain; Region: AAA_30; pfam13604
349163001087	Family description; Region: UvrD_C_2; pfam13538
349163001088	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
349163001089	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
349163001090	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
349163001091	Domain of unknown function DUF29; Region: DUF29; pfam01724
349163001092	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
349163001093	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
349163001094	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
349163001095	MobA/MobL family; Region: MobA_MobL; pfam03389
349163001096	Domain of unknown function DUF29; Region: DUF29; pfam01724
349163001097	helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225
349163001098	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
349163001099	DNA-binding site [nucleotide binding]; DNA binding site
349163001100	DnaA N-terminal domain; Region: DnaA_N; pfam11638
349163001101	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
349163001102	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163001103	Walker A motif; other site
349163001104	ATP binding site [chemical binding]; other site
349163001105	Walker B motif; other site
349163001106	arginine finger; other site
349163001107	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
349163001108	DnaA box-binding interface [nucleotide binding]; other site
349163001109	S-formylglutathione hydrolase; Region: PLN02442
349163001110	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
349163001111	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
349163001112	DNA-binding site [nucleotide binding]; DNA binding site
349163001113	RNA-binding motif; other site
349163001114	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
349163001115	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
349163001116	DNA binding residues [nucleotide binding]
349163001117	putative dimer interface [polypeptide binding]; other site
349163001118	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
349163001119	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
349163001120	dimer interface [polypeptide binding]; other site
349163001121	active site
349163001122	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
349163001123	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
349163001124	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
349163001125	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
349163001126	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349163001127	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
349163001128	substrate binding site [chemical binding]; other site
349163001129	oxyanion hole (OAH) forming residues; other site
349163001130	trimer interface [polypeptide binding]; other site
349163001131	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
349163001132	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
349163001133	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349163001134	active site
349163001135	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
349163001136	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
349163001137	substrate binding site [chemical binding]; other site
349163001138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163001139	ABC-ATPase subunit interface; other site
349163001140	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
349163001141	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
349163001142	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
349163001143	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
349163001144	TspO/MBR family; Region: TspO_MBR; pfam03073
349163001145	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349163001146	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
349163001147	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
349163001148	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
349163001149	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
349163001150	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
349163001151	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
349163001152	intersubunit interface [polypeptide binding]; other site
349163001153	active site
349163001154	Zn2+ binding site [ion binding]; other site
349163001155	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
349163001156	Cupin domain; Region: Cupin_2; pfam07883
349163001157	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
349163001158	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
349163001159	putative active site [active]
349163001160	catalytic triad [active]
349163001161	putative dimer interface [polypeptide binding]; other site
349163001162	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349163001163	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163001164	non-specific DNA binding site [nucleotide binding]; other site
349163001165	salt bridge; other site
349163001166	sequence-specific DNA binding site [nucleotide binding]; other site
349163001167	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
349163001168	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
349163001169	substrate binding site [chemical binding]; other site
349163001170	hexamer interface [polypeptide binding]; other site
349163001171	metal binding site [ion binding]; metal-binding site
349163001172	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
349163001173	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
349163001174	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
349163001175	NAD binding site [chemical binding]; other site
349163001176	homodimer interface [polypeptide binding]; other site
349163001177	active site
349163001178	substrate binding site [chemical binding]; other site
349163001179	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
349163001180	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163001181	putative ADP-binding pocket [chemical binding]; other site
349163001182	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
349163001183	CreA protein; Region: CreA; pfam05981
349163001184	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
349163001185	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
349163001186	purine monophosphate binding site [chemical binding]; other site
349163001187	dimer interface [polypeptide binding]; other site
349163001188	putative catalytic residues [active]
349163001189	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
349163001190	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
349163001191	Uncharacterized conserved protein [Function unknown]; Region: COG2128
349163001192	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
349163001193	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
349163001194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163001195	Mg2+ binding site [ion binding]; other site
349163001196	G-X-G motif; other site
349163001197	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
349163001198	anchoring element; other site
349163001199	dimer interface [polypeptide binding]; other site
349163001200	ATP binding site [chemical binding]; other site
349163001201	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
349163001202	active site
349163001203	putative metal-binding site [ion binding]; other site
349163001204	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
349163001205	cytidylate kinase; Provisional; Region: cmk; PRK00023
349163001206	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
349163001207	CMP-binding site; other site
349163001208	The sites determining sugar specificity; other site
349163001209	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
349163001210	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
349163001211	hinge; other site
349163001212	active site
349163001213	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
349163001214	TIGR02300 family protein; Region: FYDLN_acid
349163001215	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
349163001216	CoA-transferase family III; Region: CoA_transf_3; pfam02515
349163001217	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349163001218	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
349163001219	ribonuclease R; Region: RNase_R; TIGR02063
349163001220	RNB domain; Region: RNB; pfam00773
349163001221	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
349163001222	RNA binding site [nucleotide binding]; other site
349163001223	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
349163001224	protein binding site [polypeptide binding]; other site
349163001225	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
349163001226	Catalytic dyad [active]
349163001227	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
349163001228	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
349163001229	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
349163001230	Predicted amidohydrolase [General function prediction only]; Region: COG0388
349163001231	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
349163001232	putative active site [active]
349163001233	catalytic triad [active]
349163001234	putative dimer interface [polypeptide binding]; other site
349163001235	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
349163001236	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
349163001237	Cytochrome c; Region: Cytochrom_C; pfam00034
349163001238	5-aminolevulinate synthase; Validated; Region: PRK09064
349163001239	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
349163001240	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349163001241	catalytic residue [active]
349163001242	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
349163001243	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349163001244	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349163001245	P-loop; other site
349163001246	Magnesium ion binding site [ion binding]; other site
349163001247	Uncharacterized conserved protein [Function unknown]; Region: COG0062
349163001248	putative carbohydrate kinase; Provisional; Region: PRK10565
349163001249	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
349163001250	putative substrate binding site [chemical binding]; other site
349163001251	putative ATP binding site [chemical binding]; other site
349163001252	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
349163001253	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
349163001254	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
349163001255	lipoyl attachment site [posttranslational modification]; other site
349163001256	glycine dehydrogenase; Provisional; Region: PRK05367
349163001257	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
349163001258	tetramer interface [polypeptide binding]; other site
349163001259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163001260	catalytic residue [active]
349163001261	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
349163001262	tetramer interface [polypeptide binding]; other site
349163001263	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163001264	catalytic residue [active]
349163001265	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
349163001266	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
349163001267	tandem repeat interface [polypeptide binding]; other site
349163001268	oligomer interface [polypeptide binding]; other site
349163001269	active site residues [active]
349163001270	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
349163001271	tandem repeat interface [polypeptide binding]; other site
349163001272	oligomer interface [polypeptide binding]; other site
349163001273	active site residues [active]
349163001274	cell division protein MraZ; Reviewed; Region: PRK00326
349163001275	MraZ protein; Region: MraZ; pfam02381
349163001276	MraZ protein; Region: MraZ; pfam02381
349163001277	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
349163001278	MraW methylase family; Region: Methyltransf_5; cl17771
349163001279	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
349163001280	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
349163001281	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
349163001282	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
349163001283	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
349163001284	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
349163001285	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349163001286	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
349163001287	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
349163001288	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
349163001289	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349163001290	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
349163001291	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
349163001292	Mg++ binding site [ion binding]; other site
349163001293	putative catalytic motif [active]
349163001294	putative substrate binding site [chemical binding]; other site
349163001295	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
349163001296	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
349163001297	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349163001298	cell division protein FtsW; Region: ftsW; TIGR02614
349163001299	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
349163001300	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
349163001301	active site
349163001302	homodimer interface [polypeptide binding]; other site
349163001303	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
349163001304	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
349163001305	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349163001306	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
349163001307	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
349163001308	FAD binding domain; Region: FAD_binding_4; pfam01565
349163001309	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
349163001310	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
349163001311	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
349163001312	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349163001313	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
349163001314	Cell division protein FtsQ; Region: FtsQ; pfam03799
349163001315	Cell division protein FtsA; Region: FtsA; smart00842
349163001316	cell division protein FtsA; Region: ftsA; TIGR01174
349163001317	Cell division protein FtsA; Region: FtsA; pfam14450
349163001318	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
349163001319	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
349163001320	nucleotide binding site [chemical binding]; other site
349163001321	SulA interaction site; other site
349163001322	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
349163001323	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
349163001324	Competence protein; Region: Competence; pfam03772
349163001325	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
349163001326	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349163001327	active site
349163001328	Bacterial sugar transferase; Region: Bac_transf; pfam02397
349163001329	GtrA-like protein; Region: GtrA; pfam04138
349163001330	Predicted membrane protein [Function unknown]; Region: COG2246
349163001331	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
349163001332	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163001333	catalytic loop [active]
349163001334	iron binding site [ion binding]; other site
349163001335	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
349163001336	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
349163001337	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349163001338	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349163001339	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
349163001340	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
349163001341	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
349163001342	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
349163001343	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
349163001344	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
349163001345	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
349163001346	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163001347	FeS/SAM binding site; other site
349163001348	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
349163001349	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
349163001350	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
349163001351	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
349163001352	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
349163001353	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
349163001354	Isochorismatase family; Region: Isochorismatase; pfam00857
349163001355	catalytic triad [active]
349163001356	metal binding site [ion binding]; metal-binding site
349163001357	conserved cis-peptide bond; other site
349163001358	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
349163001359	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
349163001360	NAD binding site [chemical binding]; other site
349163001361	homotetramer interface [polypeptide binding]; other site
349163001362	homodimer interface [polypeptide binding]; other site
349163001363	active site
349163001364	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
349163001365	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
349163001366	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
349163001367	DNA binding residues [nucleotide binding]
349163001368	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
349163001369	dimer interface [polypeptide binding]; other site
349163001370	copper binding site [ion binding]; other site
349163001371	multidrug efflux protein; Reviewed; Region: PRK09579
349163001372	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349163001373	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349163001374	HlyD family secretion protein; Region: HlyD_3; pfam13437
349163001375	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
349163001376	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349163001377	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349163001378	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
349163001379	PaaX-like protein; Region: PaaX; pfam07848
349163001380	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
349163001381	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
349163001382	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
349163001383	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349163001384	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349163001385	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
349163001386	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
349163001387	MULE transposase domain; Region: MULE; pfam10551
349163001388	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
349163001389	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349163001390	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349163001391	aspartate aminotransferase; Provisional; Region: PRK05764
349163001392	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349163001393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163001394	homodimer interface [polypeptide binding]; other site
349163001395	catalytic residue [active]
349163001396	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349163001397	TPR motif; other site
349163001398	binding surface
349163001399	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349163001400	binding surface
349163001401	TPR motif; other site
349163001402	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
349163001403	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349163001404	TPR motif; other site
349163001405	binding surface
349163001406	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
349163001407	Flagellar protein FlbT; Region: FlbT; pfam07378
349163001408	flagellin; Provisional; Region: PRK12807
349163001409	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
349163001410	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
349163001411	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
349163001412	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
349163001413	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
349163001414	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
349163001415	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349163001416	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
349163001417	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
349163001418	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
349163001419	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
349163001420	Transposase; Region: DDE_Tnp_ISL3; pfam01610
349163001421	MarR family; Region: MarR_2; pfam12802
349163001422	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
349163001423	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
349163001424	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349163001425	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
349163001426	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
349163001427	active site lid residues [active]
349163001428	substrate binding pocket [chemical binding]; other site
349163001429	catalytic residues [active]
349163001430	substrate-Mg2+ binding site; other site
349163001431	aspartate-rich region 1; other site
349163001432	aspartate-rich region 2; other site
349163001433	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
349163001434	active site lid residues [active]
349163001435	substrate binding pocket [chemical binding]; other site
349163001436	catalytic residues [active]
349163001437	substrate-Mg2+ binding site; other site
349163001438	aspartate-rich region 1; other site
349163001439	aspartate-rich region 2; other site
349163001440	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
349163001441	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
349163001442	DXD motif; other site
349163001443	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
349163001444	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
349163001445	putative NADP binding site [chemical binding]; other site
349163001446	putative substrate binding site [chemical binding]; other site
349163001447	active site
349163001448	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
349163001449	Acyltransferase family; Region: Acyl_transf_3; pfam01757
349163001450	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
349163001451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
349163001452	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
349163001453	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
349163001454	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
349163001455	domain interfaces; other site
349163001456	active site
349163001457	tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723
349163001458	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
349163001459	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
349163001460	homodimer interface [polypeptide binding]; other site
349163001461	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
349163001462	active site pocket [active]
349163001463	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
349163001464	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
349163001465	ligand binding site; other site
349163001466	oligomer interface; other site
349163001467	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
349163001468	dimer interface [polypeptide binding]; other site
349163001469	N-terminal domain interface [polypeptide binding]; other site
349163001470	sulfate 1 binding site; other site
349163001471	glycogen synthase; Provisional; Region: PRK14099
349163001472	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
349163001473	ADP-binding pocket [chemical binding]; other site
349163001474	homodimer interface [polypeptide binding]; other site
349163001475	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
349163001476	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
349163001477	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349163001478	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349163001479	HlyD family secretion protein; Region: HlyD_3; pfam13437
349163001480	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
349163001481	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349163001482	catalytic core [active]
349163001483	Tim44-like domain; Region: Tim44; pfam04280
349163001484	MltA specific insert domain; Region: MltA; smart00925
349163001485	3D domain; Region: 3D; pfam06725
349163001486	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
349163001487	Cysteine-rich domain; Region: CCG; pfam02754
349163001488	Cysteine-rich domain; Region: CCG; pfam02754
349163001489	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
349163001490	potassium uptake protein; Region: kup; TIGR00794
349163001491	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
349163001492	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
349163001493	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
349163001494	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349163001495	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349163001496	Coenzyme A binding pocket [chemical binding]; other site
349163001497	EamA-like transporter family; Region: EamA; pfam00892
349163001498	EamA-like transporter family; Region: EamA; pfam00892
349163001499	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
349163001500	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
349163001501	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
349163001502	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
349163001503	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
349163001504	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
349163001505	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
349163001506	Ligand binding site [chemical binding]; other site
349163001507	Electron transfer flavoprotein domain; Region: ETF; pfam01012
349163001508	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
349163001509	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
349163001510	metal binding triad; other site
349163001511	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
349163001512	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
349163001513	metal binding triad; other site
349163001514	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
349163001515	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
349163001516	catalytic triad [active]
349163001517	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
349163001518	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
349163001519	diiron binding motif [ion binding]; other site
349163001520	Phasin protein; Region: Phasin_2; pfam09361
349163001521	excinuclease ABC subunit B; Provisional; Region: PRK05298
349163001522	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349163001523	ATP binding site [chemical binding]; other site
349163001524	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349163001525	nucleotide binding region [chemical binding]; other site
349163001526	ATP-binding site [chemical binding]; other site
349163001527	Ultra-violet resistance protein B; Region: UvrB; pfam12344
349163001528	UvrB/uvrC motif; Region: UVR; pfam02151
349163001529	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
349163001530	Protein of unknown function (DUF983); Region: DUF983; pfam06170
349163001531	Uncharacterized protein family (UPF0262); Region: UPF0262; pfam06793
349163001532	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
349163001533	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
349163001534	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030
349163001535	recombination factor protein RarA; Reviewed; Region: PRK13342
349163001536	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163001537	Walker A motif; other site
349163001538	ATP binding site [chemical binding]; other site
349163001539	Walker B motif; other site
349163001540	arginine finger; other site
349163001541	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
349163001542	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
349163001543	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349163001544	RNA binding surface [nucleotide binding]; other site
349163001545	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
349163001546	active site
349163001547	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
349163001548	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349163001549	Surface antigen; Region: Bac_surface_Ag; pfam01103
349163001550	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
349163001551	Family of unknown function (DUF490); Region: DUF490; pfam04357
349163001552	enolase; Provisional; Region: eno; PRK00077
349163001553	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
349163001554	dimer interface [polypeptide binding]; other site
349163001555	metal binding site [ion binding]; metal-binding site
349163001556	substrate binding pocket [chemical binding]; other site
349163001557	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
349163001558	homotrimer interaction site [polypeptide binding]; other site
349163001559	putative active site [active]
349163001560	TSCPD domain; Region: TSCPD; pfam12637
349163001561	NADH dehydrogenase; Validated; Region: PRK08183
349163001562	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
349163001563	mce related protein; Region: MCE; pfam02470
349163001564	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
349163001565	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
349163001566	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349163001567	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349163001568	ligand binding site [chemical binding]; other site
349163001569	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
349163001570	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349163001571	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349163001572	ligand binding site [chemical binding]; other site
349163001573	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
349163001574	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
349163001575	EthD domain; Region: EthD; cl17553
349163001576	pyruvate kinase; Provisional; Region: PRK06247
349163001577	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
349163001578	domain interfaces; other site
349163001579	active site
349163001580	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
349163001581	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
349163001582	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
349163001583	dimer interface [polypeptide binding]; other site
349163001584	allosteric magnesium binding site [ion binding]; other site
349163001585	active site
349163001586	aspartate-rich active site metal binding site; other site
349163001587	Schiff base residues; other site
349163001588	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
349163001589	tartrate dehydrogenase; Region: TTC; TIGR02089
349163001590	Predicted membrane protein [Function unknown]; Region: COG3174
349163001591	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
349163001592	CHAD domain; Region: CHAD; pfam05235
349163001593	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
349163001594	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
349163001595	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
349163001596	active site
349163001597	dimer interface [polypeptide binding]; other site
349163001598	effector binding site; other site
349163001599	TSCPD domain; Region: TSCPD; pfam12637
349163001600	Transcriptional regulators [Transcription]; Region: PurR; COG1609
349163001601	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349163001602	DNA binding site [nucleotide binding]
349163001603	domain linker motif; other site
349163001604	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280
349163001605	putative dimerization interface [polypeptide binding]; other site
349163001606	putative ligand binding site [chemical binding]; other site
349163001607	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
349163001608	active site
349163001609	phosphorylation site [posttranslational modification]
349163001610	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
349163001611	dimerization domain swap beta strand [polypeptide binding]; other site
349163001612	regulatory protein interface [polypeptide binding]; other site
349163001613	active site
349163001614	regulatory phosphorylation site [posttranslational modification]; other site
349163001615	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
349163001616	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
349163001617	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
349163001618	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
349163001619	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
349163001620	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
349163001621	putative substrate binding site [chemical binding]; other site
349163001622	putative ATP binding site [chemical binding]; other site
349163001623	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
349163001624	active site
349163001625	P-loop; other site
349163001626	phosphorylation site [posttranslational modification]
349163001627	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
349163001628	active site
349163001629	P-loop; other site
349163001630	phosphorylation site [posttranslational modification]
349163001631	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
349163001632	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
349163001633	CoenzymeA binding site [chemical binding]; other site
349163001634	subunit interaction site [polypeptide binding]; other site
349163001635	PHB binding site; other site
349163001636	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
349163001637	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
349163001638	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
349163001639	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
349163001640	Uncharacterized conserved protein [Function unknown]; Region: COG0398
349163001641	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
349163001642	mercuric reductase; Validated; Region: PRK06370
349163001643	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349163001644	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349163001645	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349163001646	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349163001647	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
349163001648	active site
349163001649	metal binding site [ion binding]; metal-binding site
349163001650	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163001651	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
349163001652	FeS/SAM binding site; other site
349163001653	benzoate transport; Region: 2A0115; TIGR00895
349163001654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163001655	putative substrate translocation pore; other site
349163001656	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
349163001657	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
349163001658	inhibitor site; inhibition site
349163001659	active site
349163001660	dimer interface [polypeptide binding]; other site
349163001661	catalytic residue [active]
349163001662	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
349163001663	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
349163001664	dimer interface [polypeptide binding]; other site
349163001665	NADP binding site [chemical binding]; other site
349163001666	catalytic residues [active]
349163001667	hypothetical protein; Validated; Region: PRK08245
349163001668	Peptidase family M48; Region: Peptidase_M48; cl12018
349163001669	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
349163001670	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
349163001671	putative dimer interface [polypeptide binding]; other site
349163001672	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
349163001673	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
349163001674	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
349163001675	putative ADP-binding pocket [chemical binding]; other site
349163001676	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163001677	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349163001678	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
349163001679	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349163001680	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163001681	Walker A/P-loop; other site
349163001682	ATP binding site [chemical binding]; other site
349163001683	Q-loop/lid; other site
349163001684	ABC transporter signature motif; other site
349163001685	Walker B; other site
349163001686	D-loop; other site
349163001687	H-loop/switch region; other site
349163001688	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349163001689	catalytic core [active]
349163001690	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
349163001691	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
349163001692	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
349163001693	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163001694	NAD(P) binding site [chemical binding]; other site
349163001695	active site
349163001696	aconitate hydratase; Validated; Region: PRK09277
349163001697	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
349163001698	substrate binding site [chemical binding]; other site
349163001699	ligand binding site [chemical binding]; other site
349163001700	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
349163001701	substrate binding site [chemical binding]; other site
349163001702	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
349163001703	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163001704	Walker A/P-loop; other site
349163001705	ATP binding site [chemical binding]; other site
349163001706	Q-loop/lid; other site
349163001707	ABC transporter signature motif; other site
349163001708	Walker B; other site
349163001709	D-loop; other site
349163001710	H-loop/switch region; other site
349163001711	heme exporter protein CcmB; Region: ccmB; TIGR01190
349163001712	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
349163001713	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
349163001714	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
349163001715	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
349163001716	active site
349163001717	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
349163001718	Methyltransferase domain; Region: Methyltransf_31; pfam13847
349163001719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163001720	S-adenosylmethionine binding site [chemical binding]; other site
349163001721	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
349163001722	Part of AAA domain; Region: AAA_19; pfam13245
349163001723	Family description; Region: UvrD_C_2; pfam13538
349163001724	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
349163001725	FAD binding site [chemical binding]; other site
349163001726	VacJ like lipoprotein; Region: VacJ; cl01073
349163001727	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
349163001728	ribosome maturation protein RimP; Reviewed; Region: PRK00092
349163001729	Sm and related proteins; Region: Sm_like; cl00259
349163001730	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
349163001731	putative oligomer interface [polypeptide binding]; other site
349163001732	putative RNA binding site [nucleotide binding]; other site
349163001733	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
349163001734	NusA N-terminal domain; Region: NusA_N; pfam08529
349163001735	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
349163001736	RNA binding site [nucleotide binding]; other site
349163001737	homodimer interface [polypeptide binding]; other site
349163001738	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
349163001739	G-X-X-G motif; other site
349163001740	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
349163001741	G-X-X-G motif; other site
349163001742	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
349163001743	Protein of unknown function (DUF448); Region: DUF448; pfam04296
349163001744	putative RNA binding cleft [nucleotide binding]; other site
349163001745	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
349163001746	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
349163001747	translation initiation factor IF-2; Region: IF-2; TIGR00487
349163001748	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
349163001749	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
349163001750	G1 box; other site
349163001751	putative GEF interaction site [polypeptide binding]; other site
349163001752	GTP/Mg2+ binding site [chemical binding]; other site
349163001753	Switch I region; other site
349163001754	G2 box; other site
349163001755	G3 box; other site
349163001756	Switch II region; other site
349163001757	G4 box; other site
349163001758	G5 box; other site
349163001759	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
349163001760	Translation-initiation factor 2; Region: IF-2; pfam11987
349163001761	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
349163001762	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
349163001763	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
349163001764	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
349163001765	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
349163001766	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163001767	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163001768	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163001769	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
349163001770	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
349163001771	TM-ABC transporter signature motif; other site
349163001772	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
349163001773	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
349163001774	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
349163001775	GTPase CgtA; Reviewed; Region: obgE; PRK12299
349163001776	GTP1/OBG; Region: GTP1_OBG; pfam01018
349163001777	Obg GTPase; Region: Obg; cd01898
349163001778	G1 box; other site
349163001779	GTP/Mg2+ binding site [chemical binding]; other site
349163001780	Switch I region; other site
349163001781	G2 box; other site
349163001782	G3 box; other site
349163001783	Switch II region; other site
349163001784	G4 box; other site
349163001785	G5 box; other site
349163001786	gamma-glutamyl kinase; Provisional; Region: PRK05429
349163001787	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
349163001788	nucleotide binding site [chemical binding]; other site
349163001789	homotetrameric interface [polypeptide binding]; other site
349163001790	putative phosphate binding site [ion binding]; other site
349163001791	putative allosteric binding site; other site
349163001792	PUA domain; Region: PUA; pfam01472
349163001793	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
349163001794	Mechanosensitive ion channel; Region: MS_channel; pfam00924
349163001795	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
349163001796	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
349163001797	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
349163001798	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
349163001799	RDD family; Region: RDD; pfam06271
349163001800	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
349163001801	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
349163001802	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349163001803	active site
349163001804	glutathionine S-transferase; Provisional; Region: PRK10542
349163001805	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
349163001806	C-terminal domain interface [polypeptide binding]; other site
349163001807	GSH binding site (G-site) [chemical binding]; other site
349163001808	dimer interface [polypeptide binding]; other site
349163001809	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
349163001810	N-terminal domain interface [polypeptide binding]; other site
349163001811	dimer interface [polypeptide binding]; other site
349163001812	substrate binding pocket (H-site) [chemical binding]; other site
349163001813	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349163001814	catalytic core [active]
349163001815	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
349163001816	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
349163001817	active site
349163001818	NAD binding site [chemical binding]; other site
349163001819	metal binding site [ion binding]; metal-binding site
349163001820	Amidase; Region: Amidase; cl11426
349163001821	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
349163001822	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349163001823	elongation factor G; Reviewed; Region: PRK12739
349163001824	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
349163001825	G1 box; other site
349163001826	putative GEF interaction site [polypeptide binding]; other site
349163001827	GTP/Mg2+ binding site [chemical binding]; other site
349163001828	Switch I region; other site
349163001829	G2 box; other site
349163001830	G3 box; other site
349163001831	Switch II region; other site
349163001832	G4 box; other site
349163001833	G5 box; other site
349163001834	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
349163001835	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
349163001836	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
349163001837	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
349163001838	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
349163001839	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
349163001840	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
349163001841	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
349163001842	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
349163001843	Catalytic site [active]
349163001844	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
349163001845	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
349163001846	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
349163001847	dimerization interface [polypeptide binding]; other site
349163001848	active site
349163001849	metal binding site [ion binding]; metal-binding site
349163001850	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
349163001851	dsRNA binding site [nucleotide binding]; other site
349163001852	GTPase Era; Reviewed; Region: era; PRK00089
349163001853	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
349163001854	G1 box; other site
349163001855	GTP/Mg2+ binding site [chemical binding]; other site
349163001856	Switch I region; other site
349163001857	G2 box; other site
349163001858	Switch II region; other site
349163001859	G3 box; other site
349163001860	G4 box; other site
349163001861	G5 box; other site
349163001862	KH domain; Region: KH_2; pfam07650
349163001863	G-X-X-G motif; other site
349163001864	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
349163001865	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
349163001866	active site
349163001867	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
349163001868	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
349163001869	FAD binding site [chemical binding]; other site
349163001870	substrate binding site [chemical binding]; other site
349163001871	catalytic base [active]
349163001872	dicarboxylate--CoA ligase PimA; Region: pimA; TIGR03205
349163001873	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349163001874	acyl-activating enzyme (AAE) consensus motif; other site
349163001875	AMP binding site [chemical binding]; other site
349163001876	active site
349163001877	CoA binding site [chemical binding]; other site
349163001878	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349163001879	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
349163001880	substrate binding site [chemical binding]; other site
349163001881	oxyanion hole (OAH) forming residues; other site
349163001882	trimer interface [polypeptide binding]; other site
349163001883	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
349163001884	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
349163001885	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
349163001886	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
349163001887	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
349163001888	Tetratricopeptide repeat; Region: TPR_16; pfam13432
349163001889	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349163001890	TPR motif; other site
349163001891	binding surface
349163001892	TPR repeat; Region: TPR_11; pfam13414
349163001893	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349163001894	binding surface
349163001895	TPR motif; other site
349163001896	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
349163001897	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
349163001898	diiron binding motif [ion binding]; other site
349163001899	Uncharacterized conserved protein [Function unknown]; Region: COG1633
349163001900	CCC1-related protein family; Region: CCC1_like_1; cd02437
349163001901	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
349163001902	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
349163001903	FMN binding site [chemical binding]; other site
349163001904	substrate binding site [chemical binding]; other site
349163001905	putative catalytic residue [active]
349163001906	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349163001907	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
349163001908	putative C-terminal domain interface [polypeptide binding]; other site
349163001909	putative GSH binding site (G-site) [chemical binding]; other site
349163001910	putative dimer interface [polypeptide binding]; other site
349163001911	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
349163001912	putative N-terminal domain interface [polypeptide binding]; other site
349163001913	putative dimer interface [polypeptide binding]; other site
349163001914	putative substrate binding pocket (H-site) [chemical binding]; other site
349163001915	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
349163001916	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
349163001917	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
349163001918	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
349163001919	putative active site [active]
349163001920	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163001921	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163001922	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
349163001923	active site
349163001924	dimer interface [polypeptide binding]; other site
349163001925	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
349163001926	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
349163001927	Ligand Binding Site [chemical binding]; other site
349163001928	Molecular Tunnel; other site
349163001929	dihydroorotase; Validated; Region: PRK09060
349163001930	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
349163001931	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
349163001932	active site
349163001933	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
349163001934	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
349163001935	DNA binding residues [nucleotide binding]
349163001936	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349163001937	IHF dimer interface [polypeptide binding]; other site
349163001938	IHF - DNA interface [nucleotide binding]; other site
349163001939	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
349163001940	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
349163001941	dimer interface [polypeptide binding]; other site
349163001942	active site
349163001943	CoA binding pocket [chemical binding]; other site
349163001944	putative phosphate acyltransferase; Provisional; Region: PRK05331
349163001945	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
349163001946	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
349163001947	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
349163001948	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
349163001949	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
349163001950	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
349163001951	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
349163001952	tetramerization interface [polypeptide binding]; other site
349163001953	NAD(P) binding site [chemical binding]; other site
349163001954	catalytic residues [active]
349163001955	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
349163001956	active site
349163001957	Int/Topo IB signature motif; other site
349163001958	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
349163001959	Helix-turn-helix domain; Region: HTH_17; pfam12728
349163001960	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
349163001961	active site
349163001962	catalytic residues [active]
349163001963	DNA binding site [nucleotide binding]
349163001964	Int/Topo IB signature motif; other site
349163001965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
349163001966	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349163001967	Coenzyme A binding pocket [chemical binding]; other site
349163001968	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
349163001969	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
349163001970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163001971	Walker A motif; other site
349163001972	ATP binding site [chemical binding]; other site
349163001973	Walker B motif; other site
349163001974	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349163001975	Integrase core domain; Region: rve; pfam00665
349163001976	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349163001977	Transposase [DNA replication, recombination, and repair]; Region: COG5421
349163001978	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163001979	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163001980	MULE transposase domain; Region: MULE; pfam10551
349163001981	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
349163001982	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
349163001983	inhibitor-cofactor binding pocket; inhibition site
349163001984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163001985	catalytic residue [active]
349163001986	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163001987	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163001988	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163001989	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349163001990	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163001991	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163001992	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
349163001993	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
349163001994	putative trimer interface [polypeptide binding]; other site
349163001995	putative CoA binding site [chemical binding]; other site
349163001996	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
349163001997	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
349163001998	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
349163001999	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
349163002000	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
349163002001	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
349163002002	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
349163002003	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
349163002004	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
349163002005	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163002006	Walker A/P-loop; other site
349163002007	ATP binding site [chemical binding]; other site
349163002008	Q-loop/lid; other site
349163002009	ABC transporter signature motif; other site
349163002010	Walker B; other site
349163002011	D-loop; other site
349163002012	H-loop/switch region; other site
349163002013	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349163002014	HlyD family secretion protein; Region: HlyD_3; pfam13437
349163002015	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349163002016	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349163002017	FtsX-like permease family; Region: FtsX; pfam02687
349163002018	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
349163002019	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349163002020	Walker A/P-loop; other site
349163002021	ATP binding site [chemical binding]; other site
349163002022	Q-loop/lid; other site
349163002023	ABC transporter signature motif; other site
349163002024	Walker B; other site
349163002025	D-loop; other site
349163002026	H-loop/switch region; other site
349163002027	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
349163002028	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
349163002029	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
349163002030	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
349163002031	transmembrane helices; other site
349163002032	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
349163002033	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349163002034	Walker A/P-loop; other site
349163002035	ATP binding site [chemical binding]; other site
349163002036	Q-loop/lid; other site
349163002037	ABC transporter signature motif; other site
349163002038	Walker B; other site
349163002039	D-loop; other site
349163002040	H-loop/switch region; other site
349163002041	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349163002042	FtsX-like permease family; Region: FtsX; pfam02687
349163002043	macrolide transporter subunit MacA; Provisional; Region: PRK11578
349163002044	HlyD family secretion protein; Region: HlyD_3; pfam13437
349163002045	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349163002046	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349163002047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163002048	active site
349163002049	phosphorylation site [posttranslational modification]
349163002050	intermolecular recognition site; other site
349163002051	dimerization interface [polypeptide binding]; other site
349163002052	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163002053	DNA binding site [nucleotide binding]
349163002054	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349163002055	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349163002056	dimerization interface [polypeptide binding]; other site
349163002057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163002058	ATP binding site [chemical binding]; other site
349163002059	Mg2+ binding site [ion binding]; other site
349163002060	G-X-G motif; other site
349163002061	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163002062	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349163002063	sequence-specific DNA binding site [nucleotide binding]; other site
349163002064	salt bridge; other site
349163002065	MarR family; Region: MarR_2; pfam12802
349163002066	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
349163002067	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
349163002068	Cl- selectivity filter; other site
349163002069	Cl- binding residues [ion binding]; other site
349163002070	pore gating glutamate residue; other site
349163002071	dimer interface [polypeptide binding]; other site
349163002072	FOG: CBS domain [General function prediction only]; Region: COG0517
349163002073	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
349163002074	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
349163002075	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349163002076	catalytic residue [active]
349163002077	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
349163002078	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
349163002079	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163002080	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163002081	TM-ABC transporter signature motif; other site
349163002082	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163002083	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349163002084	Walker A/P-loop; other site
349163002085	ATP binding site [chemical binding]; other site
349163002086	Q-loop/lid; other site
349163002087	ABC transporter signature motif; other site
349163002088	Walker B; other site
349163002089	D-loop; other site
349163002090	H-loop/switch region; other site
349163002091	Cupin domain; Region: Cupin_2; pfam07883
349163002092	hypothetical protein; Provisional; Region: PRK07538
349163002093	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
349163002094	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
349163002095	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
349163002096	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
349163002097	dimer interface [polypeptide binding]; other site
349163002098	ADP-ribose binding site [chemical binding]; other site
349163002099	active site
349163002100	nudix motif; other site
349163002101	metal binding site [ion binding]; metal-binding site
349163002102	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
349163002103	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
349163002104	HupF/HypC family; Region: HupF_HypC; pfam01455
349163002105	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
349163002106	Acylphosphatase; Region: Acylphosphatase; pfam00708
349163002107	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
349163002108	HypF finger; Region: zf-HYPF; pfam07503
349163002109	HypF finger; Region: zf-HYPF; pfam07503
349163002110	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
349163002111	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
349163002112	dimerization interface [polypeptide binding]; other site
349163002113	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
349163002114	ATP binding site [chemical binding]; other site
349163002115	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349163002116	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
349163002117	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
349163002118	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
349163002119	Rubredoxin; Region: Rubredoxin; pfam00301
349163002120	iron binding site [ion binding]; other site
349163002121	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
349163002122	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
349163002123	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
349163002124	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
349163002125	putative substrate-binding site; other site
349163002126	nickel binding site [ion binding]; other site
349163002127	Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125
349163002128	hydrogenase 1 large subunit; Provisional; Region: PRK10170
349163002129	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
349163002130	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
349163002131	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
349163002132	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
349163002133	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
349163002134	putative coenzyme Q binding site [chemical binding]; other site
349163002135	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
349163002136	UbiA prenyltransferase family; Region: UbiA; pfam01040
349163002137	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349163002138	active site residue [active]
349163002139	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
349163002140	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
349163002141	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
349163002142	thiosulfate reductase PhsA; Provisional; Region: PRK15488
349163002143	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
349163002144	putative [Fe4-S4] binding site [ion binding]; other site
349163002145	putative molybdopterin cofactor binding site [chemical binding]; other site
349163002146	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
349163002147	putative molybdopterin cofactor binding site; other site
349163002148	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
349163002149	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
349163002150	active site residue [active]
349163002151	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
349163002152	active site residue [active]
349163002153	High-affinity nickel-transport protein; Region: NicO; cl00964
349163002154	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
349163002155	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
349163002156	dimerization interface [polypeptide binding]; other site
349163002157	domain crossover interface; other site
349163002158	redox-dependent activation switch; other site
349163002159	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
349163002160	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
349163002161	putative ribose interaction site [chemical binding]; other site
349163002162	putative ADP binding site [chemical binding]; other site
349163002163	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
349163002164	active site
349163002165	nucleotide binding site [chemical binding]; other site
349163002166	HIGH motif; other site
349163002167	KMSKS motif; other site
349163002168	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
349163002169	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
349163002170	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
349163002171	Walker A/P-loop; other site
349163002172	ATP binding site [chemical binding]; other site
349163002173	Q-loop/lid; other site
349163002174	ABC transporter signature motif; other site
349163002175	Walker B; other site
349163002176	D-loop; other site
349163002177	H-loop/switch region; other site
349163002178	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163002179	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
349163002180	Walker A/P-loop; other site
349163002181	ATP binding site [chemical binding]; other site
349163002182	Q-loop/lid; other site
349163002183	ABC transporter signature motif; other site
349163002184	Walker B; other site
349163002185	D-loop; other site
349163002186	H-loop/switch region; other site
349163002187	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
349163002188	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
349163002189	TM-ABC transporter signature motif; other site
349163002190	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
349163002191	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163002192	TM-ABC transporter signature motif; other site
349163002193	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
349163002194	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
349163002195	dimerization interface [polypeptide binding]; other site
349163002196	ligand binding site [chemical binding]; other site
349163002197	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
349163002198	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
349163002199	putative tRNA-binding site [nucleotide binding]; other site
349163002200	B3/4 domain; Region: B3_4; pfam03483
349163002201	tRNA synthetase B5 domain; Region: B5; smart00874
349163002202	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
349163002203	dimer interface [polypeptide binding]; other site
349163002204	motif 1; other site
349163002205	motif 3; other site
349163002206	motif 2; other site
349163002207	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
349163002208	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
349163002209	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
349163002210	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
349163002211	dimer interface [polypeptide binding]; other site
349163002212	motif 1; other site
349163002213	active site
349163002214	motif 2; other site
349163002215	motif 3; other site
349163002216	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349163002217	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349163002218	ligand binding site [chemical binding]; other site
349163002219	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
349163002220	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
349163002221	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
349163002222	Ligand Binding Site [chemical binding]; other site
349163002223	FtsH Extracellular; Region: FtsH_ext; pfam06480
349163002224	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
349163002225	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163002226	Walker A motif; other site
349163002227	ATP binding site [chemical binding]; other site
349163002228	Walker B motif; other site
349163002229	arginine finger; other site
349163002230	Peptidase family M41; Region: Peptidase_M41; pfam01434
349163002231	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
349163002232	enoyl-CoA hydratase; Provisional; Region: PRK06190
349163002233	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349163002234	substrate binding site [chemical binding]; other site
349163002235	oxyanion hole (OAH) forming residues; other site
349163002236	trimer interface [polypeptide binding]; other site
349163002237	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
349163002238	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
349163002239	RNase E interface [polypeptide binding]; other site
349163002240	trimer interface [polypeptide binding]; other site
349163002241	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
349163002242	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
349163002243	RNase E interface [polypeptide binding]; other site
349163002244	trimer interface [polypeptide binding]; other site
349163002245	active site
349163002246	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
349163002247	putative nucleic acid binding region [nucleotide binding]; other site
349163002248	G-X-X-G motif; other site
349163002249	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
349163002250	RNA binding site [nucleotide binding]; other site
349163002251	domain interface; other site
349163002252	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
349163002253	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
349163002254	Predicted membrane protein [Function unknown]; Region: COG2259
349163002255	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
349163002256	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
349163002257	active site
349163002258	catalytic residues [active]
349163002259	metal binding site [ion binding]; metal-binding site
349163002260	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
349163002261	COQ9; Region: COQ9; pfam08511
349163002262	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
349163002263	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
349163002264	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
349163002265	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
349163002266	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
349163002267	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
349163002268	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
349163002269	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
349163002270	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
349163002271	putative active site; other site
349163002272	catalytic residue [active]
349163002273	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
349163002274	thiamine phosphate binding site [chemical binding]; other site
349163002275	active site
349163002276	pyrophosphate binding site [ion binding]; other site
349163002277	active site
349163002278	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
349163002279	Protein of unknown function (DUF563); Region: DUF563; pfam04577
349163002280	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349163002281	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349163002282	active site
349163002283	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349163002284	active site
349163002285	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
349163002286	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
349163002287	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
349163002288	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
349163002289	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349163002290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163002291	S-adenosylmethionine binding site [chemical binding]; other site
349163002292	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
349163002293	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
349163002294	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
349163002295	DDE superfamily endonuclease; Region: DDE_5; cl17874
349163002296	DDE superfamily endonuclease; Region: DDE_5; cl17874
349163002297	voltage-gated potassium channel; Provisional; Region: PRK10537
349163002298	Ion channel; Region: Ion_trans_2; pfam07885
349163002299	TrkA-N domain; Region: TrkA_N; pfam02254
349163002300	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
349163002301	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
349163002302	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
349163002303	ATP binding site [chemical binding]; other site
349163002304	active site
349163002305	substrate binding site [chemical binding]; other site
349163002306	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
349163002307	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
349163002308	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
349163002309	ATP synthase subunit C; Region: ATP-synt_C; cl00466
349163002310	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
349163002311	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
349163002312	AAA domain; Region: AAA_23; pfam13476
349163002313	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
349163002314	Walker A/P-loop; other site
349163002315	ATP binding site [chemical binding]; other site
349163002316	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
349163002317	ABC transporter signature motif; other site
349163002318	Walker B; other site
349163002319	D-loop; other site
349163002320	H-loop/switch region; other site
349163002321	Thioredoxin; Region: Thioredoxin_4; pfam13462
349163002322	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
349163002323	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349163002324	active site
349163002325	DNA repair protein RadA; Provisional; Region: PRK11823
349163002326	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349163002327	Walker A motif; other site
349163002328	ATP binding site [chemical binding]; other site
349163002329	Walker B motif; other site
349163002330	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
349163002331	Colicin V production protein; Region: Colicin_V; pfam02674
349163002332	amidophosphoribosyltransferase; Provisional; Region: PRK09123
349163002333	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
349163002334	active site
349163002335	tetramer interface [polypeptide binding]; other site
349163002336	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349163002337	active site
349163002338	methionine sulfoxide reductase A; Provisional; Region: PRK00058
349163002339	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
349163002340	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
349163002341	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
349163002342	putative dimer interface [polypeptide binding]; other site
349163002343	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
349163002344	active site
349163002345	catalytic residues [active]
349163002346	metal binding site [ion binding]; metal-binding site
349163002347	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
349163002348	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
349163002349	putative active site [active]
349163002350	substrate binding site [chemical binding]; other site
349163002351	putative cosubstrate binding site; other site
349163002352	catalytic site [active]
349163002353	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
349163002354	substrate binding site [chemical binding]; other site
349163002355	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
349163002356	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
349163002357	dimerization interface 3.5A [polypeptide binding]; other site
349163002358	active site
349163002359	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
349163002360	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
349163002361	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
349163002362	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
349163002363	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
349163002364	putative catalytic site [active]
349163002365	putative phosphate binding site [ion binding]; other site
349163002366	active site
349163002367	metal binding site A [ion binding]; metal-binding site
349163002368	DNA binding site [nucleotide binding]
349163002369	putative AP binding site [nucleotide binding]; other site
349163002370	putative metal binding site B [ion binding]; other site
349163002371	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
349163002372	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
349163002373	Peptidase C26; Region: Peptidase_C26; pfam07722
349163002374	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
349163002375	catalytic triad [active]
349163002376	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
349163002377	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
349163002378	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
349163002379	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
349163002380	interface (dimer of trimers) [polypeptide binding]; other site
349163002381	Substrate-binding/catalytic site; other site
349163002382	Zn-binding sites [ion binding]; other site
349163002383	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
349163002384	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
349163002385	GIY-YIG motif/motif A; other site
349163002386	active site
349163002387	catalytic site [active]
349163002388	putative DNA binding site [nucleotide binding]; other site
349163002389	metal binding site [ion binding]; metal-binding site
349163002390	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
349163002391	Hint domain; Region: Hint_2; pfam13403
349163002392	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
349163002393	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
349163002394	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
349163002395	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
349163002396	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163002397	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
349163002398	NAD(P) binding site [chemical binding]; other site
349163002399	active site
349163002400	Membrane fusogenic activity; Region: BMFP; pfam04380
349163002401	Maf-like protein; Provisional; Region: PRK14361
349163002402	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
349163002403	active site
349163002404	dimer interface [polypeptide binding]; other site
349163002405	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
349163002406	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
349163002407	putative NAD(P) binding site [chemical binding]; other site
349163002408	dimer interface [polypeptide binding]; other site
349163002409	Protein of unknown function DUF45; Region: DUF45; pfam01863
349163002410	hypothetical protein; Provisional; Region: PRK05170
349163002411	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
349163002412	putative amphipathic alpha helix; other site
349163002413	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349163002414	catalytic core [active]
349163002415	ABC-2 type transporter; Region: ABC2_membrane; cl17235
349163002416	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
349163002417	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
349163002418	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
349163002419	Walker A/P-loop; other site
349163002420	ATP binding site [chemical binding]; other site
349163002421	Q-loop/lid; other site
349163002422	ABC transporter signature motif; other site
349163002423	Walker B; other site
349163002424	D-loop; other site
349163002425	H-loop/switch region; other site
349163002426	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163002427	S-adenosylmethionine binding site [chemical binding]; other site
349163002428	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
349163002429	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
349163002430	hypothetical protein; Provisional; Region: PRK06034
349163002431	Chorismate mutase type II; Region: CM_2; cl00693
349163002432	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
349163002433	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349163002434	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163002435	homodimer interface [polypeptide binding]; other site
349163002436	catalytic residue [active]
349163002437	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
349163002438	prephenate dehydrogenase; Validated; Region: PRK08507
349163002439	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
349163002440	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
349163002441	RNA binding site [nucleotide binding]; other site
349163002442	active site
349163002443	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
349163002444	16S/18S rRNA binding site [nucleotide binding]; other site
349163002445	S13e-L30e interaction site [polypeptide binding]; other site
349163002446	25S rRNA binding site [nucleotide binding]; other site
349163002447	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
349163002448	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
349163002449	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
349163002450	dimerization domain swap beta strand [polypeptide binding]; other site
349163002451	regulatory protein interface [polypeptide binding]; other site
349163002452	active site
349163002453	regulatory phosphorylation site [posttranslational modification]; other site
349163002454	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
349163002455	active pocket/dimerization site; other site
349163002456	active site
349163002457	phosphorylation site [posttranslational modification]
349163002458	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
349163002459	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
349163002460	Hpr binding site; other site
349163002461	active site
349163002462	homohexamer subunit interaction site [polypeptide binding]; other site
349163002463	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349163002464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163002465	active site
349163002466	phosphorylation site [posttranslational modification]
349163002467	intermolecular recognition site; other site
349163002468	dimerization interface [polypeptide binding]; other site
349163002469	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163002470	DNA binding site [nucleotide binding]
349163002471	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
349163002472	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349163002473	dimerization interface [polypeptide binding]; other site
349163002474	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163002475	ATP binding site [chemical binding]; other site
349163002476	Mg2+ binding site [ion binding]; other site
349163002477	G-X-G motif; other site
349163002478	benzoate transport; Region: 2A0115; TIGR00895
349163002479	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163002480	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163002481	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
349163002482	catalytic triad [active]
349163002483	putative active site [active]
349163002484	Autotransporter beta-domain; Region: Autotransporter; smart00869
349163002485	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
349163002486	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
349163002487	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
349163002488	N- and C-terminal domain interface [polypeptide binding]; other site
349163002489	active site
349163002490	MgATP binding site [chemical binding]; other site
349163002491	catalytic site [active]
349163002492	metal binding site [ion binding]; metal-binding site
349163002493	carbohydrate binding site [chemical binding]; other site
349163002494	putative homodimer interface [polypeptide binding]; other site
349163002495	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349163002496	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
349163002497	substrate binding site [chemical binding]; other site
349163002498	ATP binding site [chemical binding]; other site
349163002499	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
349163002500	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
349163002501	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
349163002502	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349163002503	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349163002504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163002505	dimer interface [polypeptide binding]; other site
349163002506	conserved gate region; other site
349163002507	putative PBP binding loops; other site
349163002508	ABC-ATPase subunit interface; other site
349163002509	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
349163002510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163002511	dimer interface [polypeptide binding]; other site
349163002512	conserved gate region; other site
349163002513	putative PBP binding loops; other site
349163002514	ABC-ATPase subunit interface; other site
349163002515	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
349163002516	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
349163002517	Walker A/P-loop; other site
349163002518	ATP binding site [chemical binding]; other site
349163002519	Q-loop/lid; other site
349163002520	ABC transporter signature motif; other site
349163002521	Walker B; other site
349163002522	D-loop; other site
349163002523	H-loop/switch region; other site
349163002524	TOBE domain; Region: TOBE_2; pfam08402
349163002525	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163002526	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
349163002527	NAD(P) binding site [chemical binding]; other site
349163002528	active site
349163002529	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163002530	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
349163002531	NAD(P) binding site [chemical binding]; other site
349163002532	active site
349163002533	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
349163002534	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
349163002535	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
349163002536	phosphogluconate dehydratase; Validated; Region: PRK09054
349163002537	6-phosphogluconate dehydratase; Region: edd; TIGR01196
349163002538	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
349163002539	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
349163002540	active site
349163002541	intersubunit interface [polypeptide binding]; other site
349163002542	catalytic residue [active]
349163002543	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
349163002544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163002545	putative substrate translocation pore; other site
349163002546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163002547	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
349163002548	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
349163002549	transmembrane helices; other site
349163002550	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
349163002551	putative hydrophobic ligand binding site [chemical binding]; other site
349163002552	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
349163002553	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163002554	Walker A motif; other site
349163002555	ATP binding site [chemical binding]; other site
349163002556	Walker B motif; other site
349163002557	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
349163002558	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
349163002559	metal ion-dependent adhesion site (MIDAS); other site
349163002560	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
349163002561	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
349163002562	XdhC Rossmann domain; Region: XdhC_C; pfam13478
349163002563	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
349163002564	putative MPT binding site; other site
349163002565	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
349163002566	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
349163002567	Ligand binding site; other site
349163002568	metal-binding site
349163002569	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
349163002570	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
349163002571	dimerization interface [polypeptide binding]; other site
349163002572	ligand binding site [chemical binding]; other site
349163002573	NADP binding site [chemical binding]; other site
349163002574	catalytic site [active]
349163002575	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349163002576	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
349163002577	acyl-activating enzyme (AAE) consensus motif; other site
349163002578	AMP binding site [chemical binding]; other site
349163002579	active site
349163002580	CoA binding site [chemical binding]; other site
349163002581	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
349163002582	CoenzymeA binding site [chemical binding]; other site
349163002583	subunit interaction site [polypeptide binding]; other site
349163002584	PHB binding site; other site
349163002585	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349163002586	TPR motif; other site
349163002587	binding surface
349163002588	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
349163002589	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
349163002590	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
349163002591	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349163002592	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345
349163002593	putative ligand binding site [chemical binding]; other site
349163002594	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
349163002595	TM-ABC transporter signature motif; other site
349163002596	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
349163002597	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
349163002598	TM-ABC transporter signature motif; other site
349163002599	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163002600	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
349163002601	Walker A/P-loop; other site
349163002602	ATP binding site [chemical binding]; other site
349163002603	Q-loop/lid; other site
349163002604	ABC transporter signature motif; other site
349163002605	Walker B; other site
349163002606	D-loop; other site
349163002607	H-loop/switch region; other site
349163002608	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
349163002609	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
349163002610	Walker A/P-loop; other site
349163002611	ATP binding site [chemical binding]; other site
349163002612	Q-loop/lid; other site
349163002613	ABC transporter signature motif; other site
349163002614	Walker B; other site
349163002615	D-loop; other site
349163002616	H-loop/switch region; other site
349163002617	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
349163002618	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
349163002619	Transposase; Region: DDE_Tnp_ISL3; pfam01610
349163002620	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
349163002621	CHASE4 domain; Region: CHASE4; pfam05228
349163002622	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163002623	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163002624	metal binding site [ion binding]; metal-binding site
349163002625	active site
349163002626	I-site; other site
349163002627	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163002628	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
349163002629	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
349163002630	conserved cys residue [active]
349163002631	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
349163002632	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
349163002633	conserved cys residue [active]
349163002634	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349163002635	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349163002636	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
349163002637	classical (c) SDRs; Region: SDR_c; cd05233
349163002638	NAD(P) binding site [chemical binding]; other site
349163002639	active site
349163002640	acetoacetate decarboxylase; Provisional; Region: PRK02265
349163002641	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
349163002642	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
349163002643	nucleophile elbow; other site
349163002644	Patatin phospholipase; Region: DUF3734; pfam12536
349163002645	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
349163002646	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
349163002647	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
349163002648	putative inner membrane protein; Provisional; Region: PRK11099
349163002649	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
349163002650	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
349163002651	active site residue [active]
349163002652	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
349163002653	active site residue [active]
349163002654	Transcriptional regulators [Transcription]; Region: PurR; COG1609
349163002655	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349163002656	DNA binding site [nucleotide binding]
349163002657	domain linker motif; other site
349163002658	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
349163002659	dimerization interface [polypeptide binding]; other site
349163002660	ligand binding site [chemical binding]; other site
349163002661	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
349163002662	D-xylulose kinase; Region: XylB; TIGR01312
349163002663	N- and C-terminal domain interface [polypeptide binding]; other site
349163002664	active site
349163002665	MgATP binding site [chemical binding]; other site
349163002666	catalytic site [active]
349163002667	metal binding site [ion binding]; metal-binding site
349163002668	xylulose binding site [chemical binding]; other site
349163002669	homodimer interface [polypeptide binding]; other site
349163002670	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
349163002671	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
349163002672	ligand binding site [chemical binding]; other site
349163002673	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
349163002674	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349163002675	Walker A/P-loop; other site
349163002676	ATP binding site [chemical binding]; other site
349163002677	Q-loop/lid; other site
349163002678	ABC transporter signature motif; other site
349163002679	Walker B; other site
349163002680	D-loop; other site
349163002681	H-loop/switch region; other site
349163002682	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349163002683	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163002684	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163002685	TM-ABC transporter signature motif; other site
349163002686	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349163002687	IHF dimer interface [polypeptide binding]; other site
349163002688	IHF - DNA interface [nucleotide binding]; other site
349163002689	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163002690	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349163002691	NAD(P) binding site [chemical binding]; other site
349163002692	active site
349163002693	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
349163002694	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
349163002695	NADP-binding site; other site
349163002696	homotetramer interface [polypeptide binding]; other site
349163002697	substrate binding site [chemical binding]; other site
349163002698	homodimer interface [polypeptide binding]; other site
349163002699	active site
349163002700	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
349163002701	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349163002702	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349163002703	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
349163002704	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
349163002705	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
349163002706	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
349163002707	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349163002708	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
349163002709	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349163002710	motif II; other site
349163002711	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349163002712	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
349163002713	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
349163002714	Protein of unknown function, DUF488; Region: DUF488; pfam04343
349163002715	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
349163002716	sulfotransferase; Region: PLN02164
349163002717	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
349163002718	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
349163002719	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
349163002720	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
349163002721	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
349163002722	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349163002723	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349163002724	dimer interface [polypeptide binding]; other site
349163002725	putative CheW interface [polypeptide binding]; other site
349163002726	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
349163002727	GAF domain; Region: GAF; pfam01590
349163002728	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
349163002729	GAF domain; Region: GAF; pfam01590
349163002730	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163002731	PAS fold; Region: PAS_3; pfam08447
349163002732	putative active site [active]
349163002733	heme pocket [chemical binding]; other site
349163002734	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163002735	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163002736	metal binding site [ion binding]; metal-binding site
349163002737	active site
349163002738	I-site; other site
349163002739	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163002740	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
349163002741	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
349163002742	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
349163002743	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
349163002744	Fe-S cluster binding site [ion binding]; other site
349163002745	DNA binding site [nucleotide binding]
349163002746	active site
349163002747	Uncharacterized conserved protein [Function unknown]; Region: COG1432
349163002748	LabA_like proteins; Region: LabA; cd10911
349163002749	putative metal binding site [ion binding]; other site
349163002750	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
349163002751	catalytic center binding site [active]
349163002752	ATP binding site [chemical binding]; other site
349163002753	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
349163002754	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
349163002755	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349163002756	Zn2+ binding site [ion binding]; other site
349163002757	Mg2+ binding site [ion binding]; other site
349163002758	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
349163002759	synthetase active site [active]
349163002760	NTP binding site [chemical binding]; other site
349163002761	metal binding site [ion binding]; metal-binding site
349163002762	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
349163002763	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
349163002764	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
349163002765	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
349163002766	2-isopropylmalate synthase; Validated; Region: PRK00915
349163002767	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
349163002768	active site
349163002769	catalytic residues [active]
349163002770	metal binding site [ion binding]; metal-binding site
349163002771	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
349163002772	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349163002773	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
349163002774	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
349163002775	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
349163002776	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
349163002777	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
349163002778	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
349163002779	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
349163002780	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163002781	dimer interface [polypeptide binding]; other site
349163002782	conserved gate region; other site
349163002783	putative PBP binding loops; other site
349163002784	ABC-ATPase subunit interface; other site
349163002785	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
349163002786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163002787	dimer interface [polypeptide binding]; other site
349163002788	putative PBP binding loops; other site
349163002789	ABC-ATPase subunit interface; other site
349163002790	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
349163002791	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163002792	Walker A/P-loop; other site
349163002793	ATP binding site [chemical binding]; other site
349163002794	Q-loop/lid; other site
349163002795	ABC transporter signature motif; other site
349163002796	Walker B; other site
349163002797	D-loop; other site
349163002798	H-loop/switch region; other site
349163002799	TOBE domain; Region: TOBE_2; pfam08402
349163002800	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
349163002801	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
349163002802	hexamer interface [polypeptide binding]; other site
349163002803	ligand binding site [chemical binding]; other site
349163002804	putative active site [active]
349163002805	NAD(P) binding site [chemical binding]; other site
349163002806	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
349163002807	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163002808	non-specific DNA binding site [nucleotide binding]; other site
349163002809	salt bridge; other site
349163002810	sequence-specific DNA binding site [nucleotide binding]; other site
349163002811	Cupin domain; Region: Cupin_2; pfam07883
349163002812	putative aminotransferase; Validated; Region: PRK07480
349163002813	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349163002814	inhibitor-cofactor binding pocket; inhibition site
349163002815	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163002816	catalytic residue [active]
349163002817	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
349163002818	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
349163002819	Radical SAM superfamily; Region: Radical_SAM; pfam04055
349163002820	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163002821	FeS/SAM binding site; other site
349163002822	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
349163002823	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
349163002824	Substrate binding site; other site
349163002825	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
349163002826	Creatinine amidohydrolase; Region: Creatininase; cl00618
349163002827	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
349163002828	substrate binding site; other site
349163002829	dimer interface; other site
349163002830	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
349163002831	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
349163002832	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
349163002833	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
349163002834	Walker A/P-loop; other site
349163002835	ATP binding site [chemical binding]; other site
349163002836	Q-loop/lid; other site
349163002837	ABC transporter signature motif; other site
349163002838	Walker B; other site
349163002839	D-loop; other site
349163002840	H-loop/switch region; other site
349163002841	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163002842	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
349163002843	Walker A/P-loop; other site
349163002844	ATP binding site [chemical binding]; other site
349163002845	Q-loop/lid; other site
349163002846	ABC transporter signature motif; other site
349163002847	Walker B; other site
349163002848	D-loop; other site
349163002849	H-loop/switch region; other site
349163002850	pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380
349163002851	pantoate--beta-alanine ligase; Region: panC; TIGR00018
349163002852	active site
349163002853	nucleotide binding site [chemical binding]; other site
349163002854	HIGH motif; other site
349163002855	KMSKS motif; other site
349163002856	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163002857	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
349163002858	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
349163002859	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
349163002860	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
349163002861	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
349163002862	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
349163002863	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
349163002864	active site
349163002865	catalytic site [active]
349163002866	metal binding site [ion binding]; metal-binding site
349163002867	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
349163002868	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349163002869	HlyD family secretion protein; Region: HlyD_3; pfam13437
349163002870	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
349163002871	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163002872	putative substrate translocation pore; other site
349163002873	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
349163002874	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
349163002875	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
349163002876	isocitrate dehydrogenase; Validated; Region: PRK08299
349163002877	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349163002878	active site
349163002879	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163002880	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163002881	metal binding site [ion binding]; metal-binding site
349163002882	active site
349163002883	I-site; other site
349163002884	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
349163002885	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
349163002886	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
349163002887	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
349163002888	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
349163002889	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
349163002890	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
349163002891	DXD motif; other site
349163002892	PilZ domain; Region: PilZ; pfam07238
349163002893	endo-1,4-D-glucanase; Provisional; Region: PRK11097
349163002894	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
349163002895	Ycf27; Reviewed; Region: orf27; CHL00148
349163002896	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
349163002897	active site
349163002898	phosphorylation site [posttranslational modification]
349163002899	dimerization interface [polypeptide binding]; other site
349163002900	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163002901	DNA binding site [nucleotide binding]
349163002902	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349163002903	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
349163002904	ligand binding site [chemical binding]; other site
349163002905	flexible hinge region; other site
349163002906	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
349163002907	putative switch regulator; other site
349163002908	non-specific DNA interactions [nucleotide binding]; other site
349163002909	DNA binding site [nucleotide binding]
349163002910	sequence specific DNA binding site [nucleotide binding]; other site
349163002911	putative cAMP binding site [chemical binding]; other site
349163002912	osmolarity response regulator; Provisional; Region: ompR; PRK09468
349163002913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163002914	active site
349163002915	phosphorylation site [posttranslational modification]
349163002916	intermolecular recognition site; other site
349163002917	dimerization interface [polypeptide binding]; other site
349163002918	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163002919	DNA binding site [nucleotide binding]
349163002920	PAS domain; Region: PAS_9; pfam13426
349163002921	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163002922	putative active site [active]
349163002923	heme pocket [chemical binding]; other site
349163002924	PAS domain S-box; Region: sensory_box; TIGR00229
349163002925	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163002926	putative active site [active]
349163002927	heme pocket [chemical binding]; other site
349163002928	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349163002929	dimer interface [polypeptide binding]; other site
349163002930	phosphorylation site [posttranslational modification]
349163002931	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163002932	ATP binding site [chemical binding]; other site
349163002933	G-X-G motif; other site
349163002934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163002935	active site
349163002936	phosphorylation site [posttranslational modification]
349163002937	intermolecular recognition site; other site
349163002938	dimerization interface [polypeptide binding]; other site
349163002939	Bacterial PH domain; Region: DUF304; pfam03703
349163002940	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349163002941	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163002942	non-specific DNA binding site [nucleotide binding]; other site
349163002943	salt bridge; other site
349163002944	sequence-specific DNA binding site [nucleotide binding]; other site
349163002945	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
349163002946	Domain of unknown function (DUF955); Region: DUF955; pfam06114
349163002947	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
349163002948	recombination protein F; Reviewed; Region: recF; PRK00064
349163002949	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163002950	Walker A/P-loop; other site
349163002951	ATP binding site [chemical binding]; other site
349163002952	Q-loop/lid; other site
349163002953	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163002954	Walker B; other site
349163002955	D-loop; other site
349163002956	H-loop/switch region; other site
349163002957	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
349163002958	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
349163002959	active site
349163002960	Riboflavin kinase; Region: Flavokinase; smart00904
349163002961	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
349163002962	dimer interaction site [polypeptide binding]; other site
349163002963	substrate-binding tunnel; other site
349163002964	active site
349163002965	catalytic site [active]
349163002966	substrate binding site [chemical binding]; other site
349163002967	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
349163002968	Ligand binding site; other site
349163002969	Putative Catalytic site; other site
349163002970	DXD motif; other site
349163002971	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
349163002972	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163002973	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349163002974	putative substrate translocation pore; other site
349163002975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163002976	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
349163002977	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349163002978	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163002979	Walker A/P-loop; other site
349163002980	ATP binding site [chemical binding]; other site
349163002981	Q-loop/lid; other site
349163002982	ABC transporter signature motif; other site
349163002983	Walker B; other site
349163002984	D-loop; other site
349163002985	H-loop/switch region; other site
349163002986	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163002987	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163002988	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
349163002989	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
349163002990	substrate binding site; other site
349163002991	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163002992	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
349163002993	NAD(P) binding site [chemical binding]; other site
349163002994	active site
349163002995	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
349163002996	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
349163002997	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349163002998	Methyltransferase domain; Region: Methyltransf_12; pfam08242
349163002999	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
349163003000	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
349163003001	extended (e) SDRs; Region: SDR_e; cd08946
349163003002	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
349163003003	NAD(P) binding site [chemical binding]; other site
349163003004	active site
349163003005	substrate binding site [chemical binding]; other site
349163003006	Cephalosporin hydroxylase; Region: CmcI; pfam04989
349163003007	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349163003008	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349163003009	dimer interface [polypeptide binding]; other site
349163003010	putative CheW interface [polypeptide binding]; other site
349163003011	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
349163003012	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
349163003013	Cu(I) binding site [ion binding]; other site
349163003014	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
349163003015	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
349163003016	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
349163003017	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
349163003018	NADH dehydrogenase; Region: NADHdh; cl00469
349163003019	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349163003020	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
349163003021	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
349163003022	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
349163003023	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
349163003024	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
349163003025	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349163003026	hydrogenase 4 subunit B; Validated; Region: PRK06521
349163003027	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
349163003028	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
349163003029	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
349163003030	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163003031	active site
349163003032	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
349163003033	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
349163003034	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
349163003035	substrate binding site; other site
349163003036	tetramer interface; other site
349163003037	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
349163003038	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
349163003039	NAD binding site [chemical binding]; other site
349163003040	substrate binding site [chemical binding]; other site
349163003041	homodimer interface [polypeptide binding]; other site
349163003042	active site
349163003043	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
349163003044	putative ligand binding site [chemical binding]; other site
349163003045	putative catalytic site [active]
349163003046	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163003047	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163003048	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349163003049	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
349163003050	active site
349163003051	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
349163003052	Amidase; Region: Amidase; cl11426
349163003053	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
349163003054	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
349163003055	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163003056	NAD(P) binding site [chemical binding]; other site
349163003057	active site
349163003058	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
349163003059	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
349163003060	dimer interface [polypeptide binding]; other site
349163003061	acyl-activating enzyme (AAE) consensus motif; other site
349163003062	putative active site [active]
349163003063	AMP binding site [chemical binding]; other site
349163003064	putative CoA binding site [chemical binding]; other site
349163003065	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
349163003066	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
349163003067	methylcitrate synthase; Provisional; Region: PRK12351
349163003068	oxalacetate binding site [chemical binding]; other site
349163003069	citrylCoA binding site [chemical binding]; other site
349163003070	coenzyme A binding site [chemical binding]; other site
349163003071	catalytic triad [active]
349163003072	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
349163003073	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
349163003074	tetramer interface [polypeptide binding]; other site
349163003075	active site
349163003076	Mg2+/Mn2+ binding site [ion binding]; other site
349163003077	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349163003078	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
349163003079	substrate binding pocket [chemical binding]; other site
349163003080	FAD binding site [chemical binding]; other site
349163003081	catalytic base [active]
349163003082	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
349163003083	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349163003084	substrate binding site [chemical binding]; other site
349163003085	oxyanion hole (OAH) forming residues; other site
349163003086	trimer interface [polypeptide binding]; other site
349163003087	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
349163003088	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
349163003089	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
349163003090	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
349163003091	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349163003092	acyl-activating enzyme (AAE) consensus motif; other site
349163003093	AMP binding site [chemical binding]; other site
349163003094	active site
349163003095	CoA binding site [chemical binding]; other site
349163003096	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
349163003097	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163003098	NAD(P) binding site [chemical binding]; other site
349163003099	active site
349163003100	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
349163003101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163003102	ATP binding site [chemical binding]; other site
349163003103	Mg2+ binding site [ion binding]; other site
349163003104	G-X-G motif; other site
349163003105	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
349163003106	ATP binding site [chemical binding]; other site
349163003107	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
349163003108	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
349163003109	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
349163003110	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163003111	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
349163003112	lipoprotein signal peptidase; Provisional; Region: PRK14770
349163003113	lipoprotein signal peptidase; Provisional; Region: PRK14787
349163003114	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
349163003115	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349163003116	active site
349163003117	HIGH motif; other site
349163003118	nucleotide binding site [chemical binding]; other site
349163003119	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
349163003120	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
349163003121	active site
349163003122	KMSKS motif; other site
349163003123	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
349163003124	tRNA binding surface [nucleotide binding]; other site
349163003125	anticodon binding site; other site
349163003126	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
349163003127	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
349163003128	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
349163003129	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
349163003130	RNA/DNA hybrid binding site [nucleotide binding]; other site
349163003131	active site
349163003132	Hint domain; Region: Hint_2; pfam13403
349163003133	prephenate dehydratase; Provisional; Region: PRK11899
349163003134	Prephenate dehydratase; Region: PDT; pfam00800
349163003135	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
349163003136	putative L-Phe binding site [chemical binding]; other site
349163003137	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
349163003138	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
349163003139	Ligand binding site; other site
349163003140	oligomer interface; other site
349163003141	Cytochrome c2 [Energy production and conversion]; Region: COG3474
349163003142	Cytochrome c2 [Energy production and conversion]; Region: COG3474
349163003143	Cytochrome c; Region: Cytochrom_C; cl11414
349163003144	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
349163003145	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
349163003146	active site
349163003147	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349163003148	Coenzyme A binding pocket [chemical binding]; other site
349163003149	tartrate dehydrogenase; Region: TTC; TIGR02089
349163003150	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
349163003151	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
349163003152	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
349163003153	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
349163003154	putative acyl-acceptor binding pocket; other site
349163003155	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
349163003156	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
349163003157	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
349163003158	putative acyl-acceptor binding pocket; other site
349163003159	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
349163003160	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163003161	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
349163003162	dimerization interface [polypeptide binding]; other site
349163003163	rod shape-determining protein MreC; Provisional; Region: PRK13922
349163003164	rod shape-determining protein MreC; Region: MreC; pfam04085
349163003165	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
349163003166	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
349163003167	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
349163003168	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
349163003169	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
349163003170	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
349163003171	heme-binding site [chemical binding]; other site
349163003172	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
349163003173	FAD binding pocket [chemical binding]; other site
349163003174	FAD binding motif [chemical binding]; other site
349163003175	phosphate binding motif [ion binding]; other site
349163003176	beta-alpha-beta structure motif; other site
349163003177	NAD binding pocket [chemical binding]; other site
349163003178	Heme binding  pocket [chemical binding]; other site
349163003179	Putative cyclase; Region: Cyclase; pfam04199
349163003180	Putative cyclase; Region: Cyclase; cl00814
349163003181	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
349163003182	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
349163003183	acyl-activating enzyme (AAE) consensus motif; other site
349163003184	putative AMP binding site [chemical binding]; other site
349163003185	putative active site [active]
349163003186	putative CoA binding site [chemical binding]; other site
349163003187	Hint domain; Region: Hint_2; pfam13403
349163003188	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
349163003189	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
349163003190	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349163003191	RNA binding surface [nucleotide binding]; other site
349163003192	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
349163003193	oligomerization interface [polypeptide binding]; other site
349163003194	active site
349163003195	metal binding site [ion binding]; metal-binding site
349163003196	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
349163003197	active site clefts [active]
349163003198	zinc binding site [ion binding]; other site
349163003199	dimer interface [polypeptide binding]; other site
349163003200	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
349163003201	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
349163003202	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349163003203	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349163003204	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
349163003205	putative hydrophobic ligand binding site [chemical binding]; other site
349163003206	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
349163003207	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
349163003208	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163003209	catalytic loop [active]
349163003210	iron binding site [ion binding]; other site
349163003211	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
349163003212	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
349163003213	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349163003214	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
349163003215	acyl-activating enzyme (AAE) consensus motif; other site
349163003216	acyl-activating enzyme (AAE) consensus motif; other site
349163003217	putative AMP binding site [chemical binding]; other site
349163003218	putative active site [active]
349163003219	putative CoA binding site [chemical binding]; other site
349163003220	enoyl-CoA hydratase; Provisional; Region: PRK06688
349163003221	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349163003222	substrate binding site [chemical binding]; other site
349163003223	oxyanion hole (OAH) forming residues; other site
349163003224	trimer interface [polypeptide binding]; other site
349163003225	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349163003226	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349163003227	ligand binding site [chemical binding]; other site
349163003228	Uncharacterized conserved protein [Function unknown]; Region: COG1359
349163003229	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
349163003230	SnoaL-like domain; Region: SnoaL_2; pfam12680
349163003231	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349163003232	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349163003233	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163003234	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163003235	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349163003236	putative effector binding pocket; other site
349163003237	dimerization interface [polypeptide binding]; other site
349163003238	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
349163003239	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349163003240	DNA-binding site [nucleotide binding]; DNA binding site
349163003241	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349163003242	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163003243	homodimer interface [polypeptide binding]; other site
349163003244	catalytic residue [active]
349163003245	Protein of unknown function (DUF983); Region: DUF983; pfam06170
349163003246	HPP family; Region: HPP; pfam04982
349163003247	PAS fold; Region: PAS; pfam00989
349163003248	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163003249	putative active site [active]
349163003250	heme pocket [chemical binding]; other site
349163003251	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349163003252	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349163003253	dimer interface [polypeptide binding]; other site
349163003254	putative CheW interface [polypeptide binding]; other site
349163003255	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
349163003256	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349163003257	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349163003258	substrate binding pocket [chemical binding]; other site
349163003259	membrane-bound complex binding site; other site
349163003260	hinge residues; other site
349163003261	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163003262	dimer interface [polypeptide binding]; other site
349163003263	conserved gate region; other site
349163003264	putative PBP binding loops; other site
349163003265	ABC-ATPase subunit interface; other site
349163003266	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
349163003267	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
349163003268	Walker A/P-loop; other site
349163003269	ATP binding site [chemical binding]; other site
349163003270	Q-loop/lid; other site
349163003271	ABC transporter signature motif; other site
349163003272	Walker B; other site
349163003273	D-loop; other site
349163003274	H-loop/switch region; other site
349163003275	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349163003276	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
349163003277	substrate binding site [chemical binding]; other site
349163003278	ATP binding site [chemical binding]; other site
349163003279	catalytic residue [active]
349163003280	Class I aldolases; Region: Aldolase_Class_I; cl17187
349163003281	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
349163003282	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
349163003283	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
349163003284	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
349163003285	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
349163003286	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
349163003287	active site
349163003288	metal binding site [ion binding]; metal-binding site
349163003289	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
349163003290	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
349163003291	G1 box; other site
349163003292	putative GEF interaction site [polypeptide binding]; other site
349163003293	GTP/Mg2+ binding site [chemical binding]; other site
349163003294	Switch I region; other site
349163003295	G2 box; other site
349163003296	G3 box; other site
349163003297	Switch II region; other site
349163003298	G4 box; other site
349163003299	G5 box; other site
349163003300	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
349163003301	Protein of unknown function DUF91; Region: DUF91; cl00709
349163003302	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349163003303	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
349163003304	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349163003305	active site
349163003306	nucleotide binding site [chemical binding]; other site
349163003307	HIGH motif; other site
349163003308	KMSKS motif; other site
349163003309	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
349163003310	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
349163003311	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349163003312	Soluble P-type ATPase [General function prediction only]; Region: COG4087
349163003313	K+-transporting ATPase, c chain; Region: KdpC; cl00944
349163003314	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
349163003315	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
349163003316	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
349163003317	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349163003318	dimer interface [polypeptide binding]; other site
349163003319	phosphorylation site [posttranslational modification]
349163003320	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163003321	ATP binding site [chemical binding]; other site
349163003322	G-X-G motif; other site
349163003323	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349163003324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163003325	active site
349163003326	phosphorylation site [posttranslational modification]
349163003327	intermolecular recognition site; other site
349163003328	dimerization interface [polypeptide binding]; other site
349163003329	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163003330	DNA binding site [nucleotide binding]
349163003331	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
349163003332	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163003333	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
349163003334	dimerization interface [polypeptide binding]; other site
349163003335	substrate binding pocket [chemical binding]; other site
349163003336	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
349163003337	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163003338	NAD(P) binding site [chemical binding]; other site
349163003339	active site
349163003340	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
349163003341	TPP-binding site [chemical binding]; other site
349163003342	dimer interface [polypeptide binding]; other site
349163003343	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
349163003344	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
349163003345	PYR/PP interface [polypeptide binding]; other site
349163003346	dimer interface [polypeptide binding]; other site
349163003347	TPP binding site [chemical binding]; other site
349163003348	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
349163003349	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
349163003350	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
349163003351	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
349163003352	DctM-like transporters; Region: DctM; pfam06808
349163003353	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
349163003354	PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...; Region: PAF_acetylesterase_like; cd01820
349163003355	active site
349163003356	catalytic triad [active]
349163003357	oxyanion hole [active]
349163003358	specificity pocket; other site
349163003359	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
349163003360	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
349163003361	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
349163003362	Ligand binding site; other site
349163003363	Putative Catalytic site; other site
349163003364	DXD motif; other site
349163003365	Fe-S metabolism associated domain; Region: SufE; cl00951
349163003366	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
349163003367	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
349163003368	active site
349163003369	HIGH motif; other site
349163003370	dimer interface [polypeptide binding]; other site
349163003371	KMSKS motif; other site
349163003372	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
349163003373	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
349163003374	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
349163003375	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
349163003376	active site
349163003377	interdomain interaction site; other site
349163003378	putative metal-binding site [ion binding]; other site
349163003379	nucleotide binding site [chemical binding]; other site
349163003380	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
349163003381	domain I; other site
349163003382	DNA binding groove [nucleotide binding]
349163003383	phosphate binding site [ion binding]; other site
349163003384	domain II; other site
349163003385	domain III; other site
349163003386	nucleotide binding site [chemical binding]; other site
349163003387	catalytic site [active]
349163003388	domain IV; other site
349163003389	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
349163003390	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
349163003391	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
349163003392	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
349163003393	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
349163003394	DNA protecting protein DprA; Region: dprA; TIGR00732
349163003395	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
349163003396	dihydroorotase; Validated; Region: pyrC; PRK09357
349163003397	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
349163003398	active site
349163003399	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
349163003400	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
349163003401	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
349163003402	Predicted transcriptional regulator [Transcription]; Region: COG2932
349163003403	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
349163003404	Catalytic site [active]
349163003405	hypothetical protein; Provisional; Region: PRK11281
349163003406	Predicted amidohydrolase [General function prediction only]; Region: COG0388
349163003407	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
349163003408	putative active site [active]
349163003409	catalytic triad [active]
349163003410	putative dimer interface [polypeptide binding]; other site
349163003411	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
349163003412	DNA methylase; Region: N6_N4_Mtase; cl17433
349163003413	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
349163003414	dimer interface [polypeptide binding]; other site
349163003415	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
349163003416	putative radical transfer pathway; other site
349163003417	diiron center [ion binding]; other site
349163003418	tyrosyl radical; other site
349163003419	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
349163003420	Class I ribonucleotide reductase; Region: RNR_I; cd01679
349163003421	active site
349163003422	dimer interface [polypeptide binding]; other site
349163003423	catalytic residues [active]
349163003424	effector binding site; other site
349163003425	R2 peptide binding site; other site
349163003426	aspartate aminotransferase; Provisional; Region: PRK05764
349163003427	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349163003428	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163003429	homodimer interface [polypeptide binding]; other site
349163003430	catalytic residue [active]
349163003431	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
349163003432	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
349163003433	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
349163003434	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
349163003435	Walker A/P-loop; other site
349163003436	ATP binding site [chemical binding]; other site
349163003437	Q-loop/lid; other site
349163003438	ABC transporter signature motif; other site
349163003439	Walker B; other site
349163003440	D-loop; other site
349163003441	H-loop/switch region; other site
349163003442	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
349163003443	diaminopimelate decarboxylase; Region: lysA; TIGR01048
349163003444	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
349163003445	active site
349163003446	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349163003447	substrate binding site [chemical binding]; other site
349163003448	catalytic residues [active]
349163003449	dimer interface [polypeptide binding]; other site
349163003450	argininosuccinate lyase; Provisional; Region: PRK00855
349163003451	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
349163003452	active sites [active]
349163003453	tetramer interface [polypeptide binding]; other site
349163003454	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
349163003455	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349163003456	catalytic residues [active]
349163003457	argininosuccinate synthase; Provisional; Region: PRK13820
349163003458	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
349163003459	ANP binding site [chemical binding]; other site
349163003460	Substrate Binding Site II [chemical binding]; other site
349163003461	Substrate Binding Site I [chemical binding]; other site
349163003462	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
349163003463	GTP-binding protein Der; Reviewed; Region: PRK00093
349163003464	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
349163003465	G1 box; other site
349163003466	GTP/Mg2+ binding site [chemical binding]; other site
349163003467	Switch I region; other site
349163003468	G2 box; other site
349163003469	Switch II region; other site
349163003470	G3 box; other site
349163003471	G4 box; other site
349163003472	G5 box; other site
349163003473	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
349163003474	G1 box; other site
349163003475	GTP/Mg2+ binding site [chemical binding]; other site
349163003476	Switch I region; other site
349163003477	G2 box; other site
349163003478	G3 box; other site
349163003479	Switch II region; other site
349163003480	G4 box; other site
349163003481	G5 box; other site
349163003482	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
349163003483	Trp docking motif [polypeptide binding]; other site
349163003484	active site
349163003485	PQQ-like domain; Region: PQQ_2; pfam13360
349163003486	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
349163003487	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
349163003488	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
349163003489	RNA binding site [nucleotide binding]; other site
349163003490	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
349163003491	RNA binding site [nucleotide binding]; other site
349163003492	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
349163003493	RNA binding site [nucleotide binding]; other site
349163003494	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
349163003495	RNA binding site [nucleotide binding]; other site
349163003496	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
349163003497	RNA binding site [nucleotide binding]; other site
349163003498	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
349163003499	RNA binding site [nucleotide binding]; other site
349163003500	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
349163003501	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
349163003502	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
349163003503	Walker A/P-loop; other site
349163003504	ATP binding site [chemical binding]; other site
349163003505	Q-loop/lid; other site
349163003506	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
349163003507	ABC transporter signature motif; other site
349163003508	Walker B; other site
349163003509	D-loop; other site
349163003510	H-loop/switch region; other site
349163003511	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
349163003512	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
349163003513	nucleotide binding pocket [chemical binding]; other site
349163003514	K-X-D-G motif; other site
349163003515	catalytic site [active]
349163003516	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
349163003517	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
349163003518	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
349163003519	Dimer interface [polypeptide binding]; other site
349163003520	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
349163003521	Class II flagellar assembly regulator; Region: FliX; pfam10768
349163003522	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
349163003523	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
349163003524	Rod binding protein; Region: Rod-binding; pfam10135
349163003525	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349163003526	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163003527	PAS domain; Region: PAS_9; pfam13426
349163003528	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
349163003529	putative active site [active]
349163003530	heme pocket [chemical binding]; other site
349163003531	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349163003532	dimer interface [polypeptide binding]; other site
349163003533	phosphorylation site [posttranslational modification]
349163003534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163003535	ATP binding site [chemical binding]; other site
349163003536	G-X-G motif; other site
349163003537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163003538	active site
349163003539	phosphorylation site [posttranslational modification]
349163003540	intermolecular recognition site; other site
349163003541	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
349163003542	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349163003543	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
349163003544	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
349163003545	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
349163003546	Walker A/P-loop; other site
349163003547	ATP binding site [chemical binding]; other site
349163003548	Q-loop/lid; other site
349163003549	ABC transporter signature motif; other site
349163003550	Walker B; other site
349163003551	D-loop; other site
349163003552	H-loop/switch region; other site
349163003553	hypothetical protein; Validated; Region: PRK09104
349163003554	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
349163003555	metal binding site [ion binding]; metal-binding site
349163003556	putative dimer interface [polypeptide binding]; other site
349163003557	pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823
349163003558	aromatic arch; other site
349163003559	DCoH dimer interaction site [polypeptide binding]; other site
349163003560	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
349163003561	DCoH tetramer interaction site [polypeptide binding]; other site
349163003562	substrate binding site [chemical binding]; other site
349163003563	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
349163003564	active site
349163003565	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
349163003566	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163003567	MULE transposase domain; Region: MULE; pfam10551
349163003568	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
349163003569	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
349163003570	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
349163003571	Transposase; Region: HTH_Tnp_1; cl17663
349163003572	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
349163003573	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
349163003574	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
349163003575	Integrase core domain; Region: rve; pfam00665
349163003576	Integrase core domain; Region: rve_3; pfam13683
349163003577	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
349163003578	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
349163003579	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
349163003580	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
349163003581	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
349163003582	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
349163003583	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
349163003584	Transposase; Region: HTH_Tnp_1; pfam01527
349163003585	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
349163003586	Uncharacterized conserved protein [Function unknown]; Region: COG1479
349163003587	Protein of unknown function DUF262; Region: DUF262; pfam03235
349163003588	Uncharacterized conserved protein [Function unknown]; Region: COG3472
349163003589	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163003590	MULE transposase domain; Region: MULE; pfam10551
349163003591	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
349163003592	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
349163003593	Methyltransferase domain; Region: Methyltransf_26; pfam13659
349163003594	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
349163003595	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
349163003596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163003597	AAA domain; Region: AAA_23; pfam13476
349163003598	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163003599	Walker A/P-loop; other site
349163003600	ATP binding site [chemical binding]; other site
349163003601	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
349163003602	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
349163003603	putative active site [active]
349163003604	putative metal-binding site [ion binding]; other site
349163003605	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
349163003606	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
349163003607	Family description; Region: UvrD_C_2; pfam13538
349163003608	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
349163003609	Transposase; Region: DDE_Tnp_ISL3; pfam01610
349163003610	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163003611	MULE transposase domain; Region: MULE; pfam10551
349163003612	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
349163003613	Integrase core domain; Region: rve_3; pfam13683
349163003614	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
349163003615	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163003616	MULE transposase domain; Region: MULE; pfam10551
349163003617	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
349163003618	Integrase core domain; Region: rve; pfam00665
349163003619	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349163003620	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349163003621	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349163003622	Putative phage integrase; Region: Phage_Integr_2; pfam13009
349163003623	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
349163003624	DNA binding site [nucleotide binding]
349163003625	active site
349163003626	Int/Topo IB signature motif; other site
349163003627	catalytic residues [active]
349163003628	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
349163003629	active site
349163003630	catalytic residues [active]
349163003631	DNA binding site [nucleotide binding]
349163003632	Int/Topo IB signature motif; other site
349163003633	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
349163003634	ligand binding site [chemical binding]; other site
349163003635	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
349163003636	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349163003637	putative C-terminal domain interface [polypeptide binding]; other site
349163003638	putative GSH binding site (G-site) [chemical binding]; other site
349163003639	putative dimer interface [polypeptide binding]; other site
349163003640	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
349163003641	putative substrate binding pocket (H-site) [chemical binding]; other site
349163003642	putative N-terminal domain interface [polypeptide binding]; other site
349163003643	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
349163003644	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
349163003645	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
349163003646	dihydropteroate synthase; Region: DHPS; TIGR01496
349163003647	substrate binding pocket [chemical binding]; other site
349163003648	dimer interface [polypeptide binding]; other site
349163003649	inhibitor binding site; inhibition site
349163003650	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
349163003651	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
349163003652	active site
349163003653	substrate binding site [chemical binding]; other site
349163003654	metal binding site [ion binding]; metal-binding site
349163003655	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
349163003656	dimer interface [polypeptide binding]; other site
349163003657	substrate binding site [chemical binding]; other site
349163003658	ATP binding site [chemical binding]; other site
349163003659	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
349163003660	AAA domain; Region: AAA_31; pfam13614
349163003661	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
349163003662	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
349163003663	metal binding site [ion binding]; metal-binding site
349163003664	active site
349163003665	phosphoribulokinase; Provisional; Region: PRK15453
349163003666	active site
349163003667	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
349163003668	intersubunit interface [polypeptide binding]; other site
349163003669	active site
349163003670	zinc binding site [ion binding]; other site
349163003671	Na+ binding site [ion binding]; other site
349163003672	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
349163003673	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
349163003674	homodimer interface [polypeptide binding]; other site
349163003675	active site
349163003676	heterodimer interface [polypeptide binding]; other site
349163003677	catalytic residue [active]
349163003678	metal binding site [ion binding]; metal-binding site
349163003679	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
349163003680	multimerization interface [polypeptide binding]; other site
349163003681	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
349163003682	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163003683	Walker A motif; other site
349163003684	ATP binding site [chemical binding]; other site
349163003685	Walker B motif; other site
349163003686	arginine finger; other site
349163003687	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
349163003688	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
349163003689	substrate binding site [chemical binding]; other site
349163003690	hexamer interface [polypeptide binding]; other site
349163003691	metal binding site [ion binding]; metal-binding site
349163003692	cytosine deaminase; Validated; Region: PRK07572
349163003693	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
349163003694	active site
349163003695	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
349163003696	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
349163003697	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
349163003698	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
349163003699	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
349163003700	NAD binding site [chemical binding]; other site
349163003701	homotetramer interface [polypeptide binding]; other site
349163003702	homodimer interface [polypeptide binding]; other site
349163003703	substrate binding site [chemical binding]; other site
349163003704	active site
349163003705	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
349163003706	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
349163003707	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
349163003708	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
349163003709	Walker A/P-loop; other site
349163003710	ATP binding site [chemical binding]; other site
349163003711	Q-loop/lid; other site
349163003712	ABC transporter signature motif; other site
349163003713	Walker B; other site
349163003714	D-loop; other site
349163003715	H-loop/switch region; other site
349163003716	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
349163003717	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
349163003718	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
349163003719	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
349163003720	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
349163003721	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
349163003722	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
349163003723	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163003724	catalytic loop [active]
349163003725	iron binding site [ion binding]; other site
349163003726	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
349163003727	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
349163003728	[4Fe-4S] binding site [ion binding]; other site
349163003729	molybdopterin cofactor binding site; other site
349163003730	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
349163003731	molybdopterin cofactor binding site; other site
349163003732	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349163003733	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
349163003734	SLBB domain; Region: SLBB; pfam10531
349163003735	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
349163003736	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
349163003737	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
349163003738	putative dimer interface [polypeptide binding]; other site
349163003739	[2Fe-2S] cluster binding site [ion binding]; other site
349163003740	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163003741	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163003742	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
349163003743	dimerization interface [polypeptide binding]; other site
349163003744	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
349163003745	6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240
349163003746	putative NAD(P) binding site [chemical binding]; other site
349163003747	catalytic Zn binding site [ion binding]; other site
349163003748	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
349163003749	acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515
349163003750	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
349163003751	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
349163003752	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
349163003753	catalytic triad [active]
349163003754	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
349163003755	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163003756	putative substrate translocation pore; other site
349163003757	Domain of unknown function (DUF202); Region: DUF202; cl09954
349163003758	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
349163003759	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
349163003760	homodimer interface [polypeptide binding]; other site
349163003761	substrate-cofactor binding pocket; other site
349163003762	catalytic residue [active]
349163003763	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
349163003764	MarR family; Region: MarR_2; pfam12802
349163003765	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349163003766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163003767	active site
349163003768	phosphorylation site [posttranslational modification]
349163003769	intermolecular recognition site; other site
349163003770	dimerization interface [polypeptide binding]; other site
349163003771	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163003772	DNA binding site [nucleotide binding]
349163003773	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
349163003774	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349163003775	dimer interface [polypeptide binding]; other site
349163003776	phosphorylation site [posttranslational modification]
349163003777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163003778	ATP binding site [chemical binding]; other site
349163003779	Mg2+ binding site [ion binding]; other site
349163003780	G-X-G motif; other site
349163003781	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
349163003782	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163003783	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
349163003784	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
349163003785	DEAD-like helicases superfamily; Region: DEXDc; smart00487
349163003786	ATP binding site [chemical binding]; other site
349163003787	Mg++ binding site [ion binding]; other site
349163003788	motif III; other site
349163003789	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349163003790	nucleotide binding region [chemical binding]; other site
349163003791	ATP-binding site [chemical binding]; other site
349163003792	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
349163003793	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349163003794	FAD binding site [chemical binding]; other site
349163003795	substrate binding pocket [chemical binding]; other site
349163003796	catalytic base [active]
349163003797	PAS domain; Region: PAS_9; pfam13426
349163003798	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163003799	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163003800	metal binding site [ion binding]; metal-binding site
349163003801	active site
349163003802	I-site; other site
349163003803	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163003804	Yqey-like protein; Region: YqeY; cl17540
349163003805	DNA primase; Validated; Region: dnaG; PRK05667
349163003806	CHC2 zinc finger; Region: zf-CHC2; pfam01807
349163003807	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
349163003808	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
349163003809	active site
349163003810	metal binding site [ion binding]; metal-binding site
349163003811	interdomain interaction site; other site
349163003812	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
349163003813	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
349163003814	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
349163003815	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
349163003816	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349163003817	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
349163003818	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349163003819	DNA binding residues [nucleotide binding]
349163003820	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
349163003821	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
349163003822	active site
349163003823	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
349163003824	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
349163003825	active site
349163003826	homotetramer interface [polypeptide binding]; other site
349163003827	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
349163003828	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
349163003829	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
349163003830	Protein of unknown function (DUF461); Region: DUF461; pfam04314
349163003831	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
349163003832	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349163003833	Cu(I) binding site [ion binding]; other site
349163003834	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
349163003835	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
349163003836	GatB domain; Region: GatB_Yqey; smart00845
349163003837	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
349163003838	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
349163003839	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
349163003840	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
349163003841	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
349163003842	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
349163003843	catalytic residues [active]
349163003844	Phosphoesterase family; Region: Phosphoesterase; pfam04185
349163003845	Phosphoesterase family; Region: Phosphoesterase; pfam04185
349163003846	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349163003847	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349163003848	catalytic residue [active]
349163003849	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
349163003850	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
349163003851	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349163003852	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
349163003853	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
349163003854	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
349163003855	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
349163003856	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349163003857	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349163003858	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
349163003859	Type II/IV secretion system protein; Region: T2SE; pfam00437
349163003860	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
349163003861	Walker A motif; other site
349163003862	ATP binding site [chemical binding]; other site
349163003863	Walker B motif; other site
349163003864	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
349163003865	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
349163003866	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
349163003867	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
349163003868	Phosphoesterase family; Region: Phosphoesterase; pfam04185
349163003869	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
349163003870	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349163003871	N-terminal plug; other site
349163003872	ligand-binding site [chemical binding]; other site
349163003873	GMP synthase; Reviewed; Region: guaA; PRK00074
349163003874	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
349163003875	AMP/PPi binding site [chemical binding]; other site
349163003876	candidate oxyanion hole; other site
349163003877	catalytic triad [active]
349163003878	potential glutamine specificity residues [chemical binding]; other site
349163003879	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
349163003880	ATP Binding subdomain [chemical binding]; other site
349163003881	Ligand Binding sites [chemical binding]; other site
349163003882	Dimerization subdomain; other site
349163003883	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
349163003884	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
349163003885	putative active site [active]
349163003886	Ap4A binding site [chemical binding]; other site
349163003887	nudix motif; other site
349163003888	putative metal binding site [ion binding]; other site
349163003889	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
349163003890	NodB motif; other site
349163003891	putative active site [active]
349163003892	putative catalytic site [active]
349163003893	Zn binding site [ion binding]; other site
349163003894	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
349163003895	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
349163003896	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
349163003897	protein binding site [polypeptide binding]; other site
349163003898	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
349163003899	Catalytic dyad [active]
349163003900	Peptidase family M23; Region: Peptidase_M23; pfam01551
349163003901	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
349163003902	phosphoglyceromutase; Provisional; Region: PRK05434
349163003903	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
349163003904	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
349163003905	active site
349163003906	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
349163003907	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
349163003908	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
349163003909	threonine dehydratase; Provisional; Region: PRK07334
349163003910	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
349163003911	tetramer interface [polypeptide binding]; other site
349163003912	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163003913	catalytic residue [active]
349163003914	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
349163003915	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
349163003916	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
349163003917	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
349163003918	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
349163003919	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349163003920	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
349163003921	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
349163003922	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349163003923	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349163003924	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
349163003925	IMP binding site; other site
349163003926	dimer interface [polypeptide binding]; other site
349163003927	partial ornithine binding site; other site
349163003928	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
349163003929	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
349163003930	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
349163003931	catalytic site [active]
349163003932	subunit interface [polypeptide binding]; other site
349163003933	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
349163003934	MutS domain I; Region: MutS_I; pfam01624
349163003935	MutS domain III; Region: MutS_III; pfam05192
349163003936	MutS domain V; Region: MutS_V; pfam00488
349163003937	Walker A/P-loop; other site
349163003938	ATP binding site [chemical binding]; other site
349163003939	Q-loop/lid; other site
349163003940	ABC transporter signature motif; other site
349163003941	Walker B; other site
349163003942	D-loop; other site
349163003943	H-loop/switch region; other site
349163003944	PII uridylyl-transferase; Provisional; Region: PRK05092
349163003945	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
349163003946	metal binding triad; other site
349163003947	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
349163003948	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
349163003949	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
349163003950	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
349163003951	active site
349163003952	catalytic triad [active]
349163003953	oxyanion hole [active]
349163003954	Autotransporter beta-domain; Region: Autotransporter; smart00869
349163003955	trigger factor; Provisional; Region: tig; PRK01490
349163003956	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
349163003957	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
349163003958	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
349163003959	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
349163003960	oligomer interface [polypeptide binding]; other site
349163003961	active site residues [active]
349163003962	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
349163003963	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
349163003964	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163003965	Walker A motif; other site
349163003966	ATP binding site [chemical binding]; other site
349163003967	Walker B motif; other site
349163003968	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
349163003969	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
349163003970	Found in ATP-dependent protease La (LON); Region: LON; smart00464
349163003971	Found in ATP-dependent protease La (LON); Region: LON; smart00464
349163003972	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163003973	Walker A motif; other site
349163003974	ATP binding site [chemical binding]; other site
349163003975	Walker B motif; other site
349163003976	arginine finger; other site
349163003977	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
349163003978	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349163003979	IHF dimer interface [polypeptide binding]; other site
349163003980	IHF - DNA interface [nucleotide binding]; other site
349163003981	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
349163003982	NADH dehydrogenase subunit B; Validated; Region: PRK06411
349163003983	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
349163003984	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
349163003985	NADH dehydrogenase subunit D; Validated; Region: PRK06075
349163003986	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
349163003987	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
349163003988	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
349163003989	putative dimer interface [polypeptide binding]; other site
349163003990	[2Fe-2S] cluster binding site [ion binding]; other site
349163003991	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
349163003992	SLBB domain; Region: SLBB; pfam10531
349163003993	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
349163003994	NADH dehydrogenase subunit G; Validated; Region: PRK09130
349163003995	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163003996	catalytic loop [active]
349163003997	iron binding site [ion binding]; other site
349163003998	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
349163003999	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
349163004000	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
349163004001	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
349163004002	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
349163004003	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
349163004004	4Fe-4S binding domain; Region: Fer4; pfam00037
349163004005	4Fe-4S binding domain; Region: Fer4; pfam00037
349163004006	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
349163004007	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
349163004008	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
349163004009	NADH dehydrogenase subunit 5; Provisional; Region: ND5; MTH00032
349163004010	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
349163004011	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349163004012	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
349163004013	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349163004014	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
349163004015	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349163004016	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
349163004017	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
349163004018	pantothenate kinase; Reviewed; Region: PRK13318
349163004019	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
349163004020	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349163004021	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
349163004022	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
349163004023	prolyl-tRNA synthetase; Provisional; Region: PRK12325
349163004024	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
349163004025	dimer interface [polypeptide binding]; other site
349163004026	motif 1; other site
349163004027	active site
349163004028	motif 2; other site
349163004029	motif 3; other site
349163004030	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
349163004031	anticodon binding site; other site
349163004032	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
349163004033	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349163004034	FtsX-like permease family; Region: FtsX; pfam02687
349163004035	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
349163004036	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349163004037	Walker A/P-loop; other site
349163004038	ATP binding site [chemical binding]; other site
349163004039	Q-loop/lid; other site
349163004040	ABC transporter signature motif; other site
349163004041	Walker B; other site
349163004042	D-loop; other site
349163004043	H-loop/switch region; other site
349163004044	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
349163004045	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349163004046	Predicted membrane protein [Function unknown]; Region: COG3431
349163004047	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
349163004048	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349163004049	ABC transporter; Region: ABC_tran_2; pfam12848
349163004050	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349163004051	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
349163004052	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
349163004053	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349163004054	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
349163004055	putative catalytic site [active]
349163004056	putative phosphate binding site [ion binding]; other site
349163004057	active site
349163004058	metal binding site A [ion binding]; metal-binding site
349163004059	DNA binding site [nucleotide binding]
349163004060	putative AP binding site [nucleotide binding]; other site
349163004061	putative metal binding site B [ion binding]; other site
349163004062	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
349163004063	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349163004064	Zn2+ binding site [ion binding]; other site
349163004065	Mg2+ binding site [ion binding]; other site
349163004066	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
349163004067	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
349163004068	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
349163004069	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
349163004070	active site
349163004071	HIGH motif; other site
349163004072	KMSK motif region; other site
349163004073	tRNA binding surface [nucleotide binding]; other site
349163004074	DALR anticodon binding domain; Region: DALR_1; smart00836
349163004075	anticodon binding site; other site
349163004076	Sporulation related domain; Region: SPOR; pfam05036
349163004077	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
349163004078	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
349163004079	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
349163004080	Peptidase family M50; Region: Peptidase_M50; pfam02163
349163004081	active site
349163004082	putative substrate binding region [chemical binding]; other site
349163004083	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
349163004084	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
349163004085	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
349163004086	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
349163004087	seryl-tRNA synthetase; Provisional; Region: PRK05431
349163004088	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
349163004089	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
349163004090	dimer interface [polypeptide binding]; other site
349163004091	active site
349163004092	motif 1; other site
349163004093	motif 2; other site
349163004094	motif 3; other site
349163004095	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
349163004096	Predicted transporter component [General function prediction only]; Region: COG2391
349163004097	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349163004098	dimerization interface [polypeptide binding]; other site
349163004099	putative DNA binding site [nucleotide binding]; other site
349163004100	putative Zn2+ binding site [ion binding]; other site
349163004101	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
349163004102	ThiS interaction site; other site
349163004103	putative active site [active]
349163004104	tetramer interface [polypeptide binding]; other site
349163004105	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
349163004106	thiS-thiF/thiG interaction site; other site
349163004107	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
349163004108	hydroxyglutarate oxidase; Provisional; Region: PRK11728
349163004109	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
349163004110	ThiC-associated domain; Region: ThiC-associated; pfam13667
349163004111	ThiC family; Region: ThiC; pfam01964
349163004112	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163004113	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163004114	metal binding site [ion binding]; metal-binding site
349163004115	active site
349163004116	I-site; other site
349163004117	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163004118	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
349163004119	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
349163004120	catalytic residues [active]
349163004121	Transglycosylase SLT domain; Region: SLT_2; pfam13406
349163004122	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349163004123	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349163004124	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
349163004125	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
349163004126	thymidylate kinase; Validated; Region: tmk; PRK00698
349163004127	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
349163004128	TMP-binding site; other site
349163004129	ATP-binding site [chemical binding]; other site
349163004130	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
349163004131	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
349163004132	Walker A motif; other site
349163004133	ATP binding site [chemical binding]; other site
349163004134	Walker B motif; other site
349163004135	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
349163004136	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
349163004137	active site
349163004138	HIGH motif; other site
349163004139	KMSKS motif; other site
349163004140	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
349163004141	tRNA binding surface [nucleotide binding]; other site
349163004142	anticodon binding site; other site
349163004143	flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397
349163004144	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
349163004145	Uncharacterized conserved protein [Function unknown]; Region: COG0398
349163004146	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
349163004147	Ligand binding site; other site
349163004148	Putative Catalytic site; other site
349163004149	DXD motif; other site
349163004150	Transcriptional regulators [Transcription]; Region: MarR; COG1846
349163004151	MarR family; Region: MarR; pfam01047
349163004152	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349163004153	Coenzyme A binding pocket [chemical binding]; other site
349163004154	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
349163004155	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
349163004156	active site
349163004157	metal binding site [ion binding]; metal-binding site
349163004158	hexamer interface [polypeptide binding]; other site
349163004159	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
349163004160	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
349163004161	active site
349163004162	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
349163004163	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163004164	Walker A/P-loop; other site
349163004165	ATP binding site [chemical binding]; other site
349163004166	Q-loop/lid; other site
349163004167	ABC transporter signature motif; other site
349163004168	Walker B; other site
349163004169	D-loop; other site
349163004170	H-loop/switch region; other site
349163004171	TOBE domain; Region: TOBE_2; pfam08402
349163004172	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
349163004173	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
349163004174	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
349163004175	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
349163004176	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
349163004177	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
349163004178	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
349163004179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163004180	dimer interface [polypeptide binding]; other site
349163004181	conserved gate region; other site
349163004182	putative PBP binding loops; other site
349163004183	ABC-ATPase subunit interface; other site
349163004184	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
349163004185	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163004186	Walker A/P-loop; other site
349163004187	ATP binding site [chemical binding]; other site
349163004188	Q-loop/lid; other site
349163004189	ABC transporter signature motif; other site
349163004190	Walker B; other site
349163004191	D-loop; other site
349163004192	H-loop/switch region; other site
349163004193	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
349163004194	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
349163004195	NAD(P) binding site [chemical binding]; other site
349163004196	catalytic residues [active]
349163004197	choline dehydrogenase; Validated; Region: PRK02106
349163004198	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
349163004199	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
349163004200	hydroxyglutarate oxidase; Provisional; Region: PRK11728
349163004201	Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767
349163004202	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
349163004203	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
349163004204	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
349163004205	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
349163004206	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
349163004207	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
349163004208	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
349163004209	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
349163004210	Ligand Binding Site [chemical binding]; other site
349163004211	Electron transfer flavoprotein domain; Region: ETF; smart00893
349163004212	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
349163004213	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
349163004214	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
349163004215	4Fe-4S binding domain; Region: Fer4; pfam00037
349163004216	Cysteine-rich domain; Region: CCG; pfam02754
349163004217	Cysteine-rich domain; Region: CCG; pfam02754
349163004218	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
349163004219	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
349163004220	putative active site [active]
349163004221	putative FMN binding site [chemical binding]; other site
349163004222	putative substrate binding site [chemical binding]; other site
349163004223	putative catalytic residue [active]
349163004224	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
349163004225	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
349163004226	conserved cys residue [active]
349163004227	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349163004228	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349163004229	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
349163004230	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
349163004231	FAD binding pocket [chemical binding]; other site
349163004232	FAD binding motif [chemical binding]; other site
349163004233	phosphate binding motif [ion binding]; other site
349163004234	beta-alpha-beta structure motif; other site
349163004235	NAD binding pocket [chemical binding]; other site
349163004236	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163004237	catalytic loop [active]
349163004238	iron binding site [ion binding]; other site
349163004239	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
349163004240	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
349163004241	[2Fe-2S] cluster binding site [ion binding]; other site
349163004242	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
349163004243	putative alpha subunit interface [polypeptide binding]; other site
349163004244	putative active site [active]
349163004245	putative substrate binding site [chemical binding]; other site
349163004246	Fe binding site [ion binding]; other site
349163004247	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
349163004248	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
349163004249	conserved cys residue [active]
349163004250	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349163004251	Sulfatase; Region: Sulfatase; cl17466
349163004252	choline-sulfatase; Region: chol_sulfatase; TIGR03417
349163004253	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
349163004254	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
349163004255	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163004256	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349163004257	dimerization interface [polypeptide binding]; other site
349163004258	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
349163004259	Methyltransferase domain; Region: Methyltransf_11; pfam08241
349163004260	aspartate kinase; Reviewed; Region: PRK06635
349163004261	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
349163004262	putative nucleotide binding site [chemical binding]; other site
349163004263	putative catalytic residues [active]
349163004264	putative Mg ion binding site [ion binding]; other site
349163004265	putative aspartate binding site [chemical binding]; other site
349163004266	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
349163004267	putative allosteric regulatory site; other site
349163004268	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
349163004269	putative allosteric regulatory residue; other site
349163004270	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
349163004271	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
349163004272	FMN binding site [chemical binding]; other site
349163004273	substrate binding site [chemical binding]; other site
349163004274	putative catalytic residue [active]
349163004275	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
349163004276	GAF domain; Region: GAF; pfam01590
349163004277	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
349163004278	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
349163004279	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
349163004280	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
349163004281	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163004282	non-specific DNA binding site [nucleotide binding]; other site
349163004283	salt bridge; other site
349163004284	sequence-specific DNA binding site [nucleotide binding]; other site
349163004285	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
349163004286	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
349163004287	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
349163004288	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
349163004289	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
349163004290	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
349163004291	dimer interface [polypeptide binding]; other site
349163004292	motif 1; other site
349163004293	active site
349163004294	motif 2; other site
349163004295	motif 3; other site
349163004296	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
349163004297	anticodon binding site; other site
349163004298	peptide chain release factor 1; Validated; Region: prfA; PRK00591
349163004299	PCRF domain; Region: PCRF; pfam03462
349163004300	RF-1 domain; Region: RF-1; pfam00472
349163004301	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
349163004302	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349163004303	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
349163004304	Putative phosphatase (DUF442); Region: DUF442; cl17385
349163004305	CHAP domain; Region: CHAP; cl17642
349163004306	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
349163004307	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
349163004308	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
349163004309	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
349163004310	active site
349163004311	HIGH motif; other site
349163004312	dimer interface [polypeptide binding]; other site
349163004313	KMSKS motif; other site
349163004314	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
349163004315	active site
349163004316	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
349163004317	substrate binding site [chemical binding]; other site
349163004318	metal binding site [ion binding]; metal-binding site
349163004319	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
349163004320	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
349163004321	active site
349163004322	tetramer interface; other site
349163004323	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
349163004324	active site
349163004325	catalytic site [active]
349163004326	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349163004327	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349163004328	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
349163004329	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
349163004330	putative homodimer interface [polypeptide binding]; other site
349163004331	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
349163004332	heterodimer interface [polypeptide binding]; other site
349163004333	homodimer interface [polypeptide binding]; other site
349163004334	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
349163004335	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
349163004336	Autotransporter beta-domain; Region: Autotransporter; smart00869
349163004337	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349163004338	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349163004339	active site
349163004340	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
349163004341	active site
349163004342	catalytic residues [active]
349163004343	recombinase A; Provisional; Region: recA; PRK09354
349163004344	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
349163004345	hexamer interface [polypeptide binding]; other site
349163004346	Walker A motif; other site
349163004347	ATP binding site [chemical binding]; other site
349163004348	Walker B motif; other site
349163004349	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
349163004350	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
349163004351	motif 1; other site
349163004352	active site
349163004353	motif 2; other site
349163004354	motif 3; other site
349163004355	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
349163004356	DHHA1 domain; Region: DHHA1; pfam02272
349163004357	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
349163004358	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
349163004359	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
349163004360	NAD(P) binding site [chemical binding]; other site
349163004361	catalytic residues [active]
349163004362	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
349163004363	NAD(P) binding site [chemical binding]; other site
349163004364	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
349163004365	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
349163004366	NAD(P) binding site [chemical binding]; other site
349163004367	homodimer interface [polypeptide binding]; other site
349163004368	substrate binding site [chemical binding]; other site
349163004369	active site
349163004370	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
349163004371	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
349163004372	inhibitor-cofactor binding pocket; inhibition site
349163004373	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163004374	catalytic residue [active]
349163004375	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
349163004376	TAP-like protein; Region: Abhydrolase_4; pfam08386
349163004377	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
349163004378	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
349163004379	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
349163004380	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
349163004381	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163004382	putative substrate translocation pore; other site
349163004383	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
349163004384	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
349163004385	Walker A/P-loop; other site
349163004386	ATP binding site [chemical binding]; other site
349163004387	Q-loop/lid; other site
349163004388	ABC transporter signature motif; other site
349163004389	Walker B; other site
349163004390	D-loop; other site
349163004391	H-loop/switch region; other site
349163004392	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163004393	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
349163004394	Walker A/P-loop; other site
349163004395	ATP binding site [chemical binding]; other site
349163004396	Q-loop/lid; other site
349163004397	ABC transporter signature motif; other site
349163004398	Walker B; other site
349163004399	D-loop; other site
349163004400	H-loop/switch region; other site
349163004401	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
349163004402	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
349163004403	TM-ABC transporter signature motif; other site
349163004404	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
349163004405	TM-ABC transporter signature motif; other site
349163004406	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349163004407	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
349163004408	putative ligand binding site [chemical binding]; other site
349163004409	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
349163004410	S-adenosylmethionine synthetase; Validated; Region: PRK05250
349163004411	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
349163004412	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
349163004413	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
349163004414	dihydrodipicolinate reductase; Provisional; Region: PRK00048
349163004415	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
349163004416	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
349163004417	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
349163004418	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349163004419	Coenzyme A binding pocket [chemical binding]; other site
349163004420	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
349163004421	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349163004422	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
349163004423	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
349163004424	Fe-S cluster binding site [ion binding]; other site
349163004425	active site
349163004426	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
349163004427	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349163004428	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349163004429	catalytic residue [active]
349163004430	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349163004431	binding surface
349163004432	TPR motif; other site
349163004433	TPR repeat; Region: TPR_11; pfam13414
349163004434	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349163004435	TPR repeat; Region: TPR_11; pfam13414
349163004436	binding surface
349163004437	TPR motif; other site
349163004438	TPR repeat; Region: TPR_11; pfam13414
349163004439	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349163004440	binding surface
349163004441	TPR motif; other site
349163004442	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163004443	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
349163004444	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
349163004445	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
349163004446	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
349163004447	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163004448	ligand binding site [chemical binding]; other site
349163004449	dimerization interface [polypeptide binding]; other site
349163004450	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163004451	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163004452	TM-ABC transporter signature motif; other site
349163004453	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
349163004454	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349163004455	Walker A/P-loop; other site
349163004456	ATP binding site [chemical binding]; other site
349163004457	Q-loop/lid; other site
349163004458	ABC transporter signature motif; other site
349163004459	Walker B; other site
349163004460	D-loop; other site
349163004461	H-loop/switch region; other site
349163004462	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349163004463	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
349163004464	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054
349163004465	transcriptional regulator NanR; Provisional; Region: PRK03837
349163004466	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349163004467	DNA-binding site [nucleotide binding]; DNA binding site
349163004468	FCD domain; Region: FCD; pfam07729
349163004469	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
349163004470	Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207
349163004471	dimer interface [polypeptide binding]; other site
349163004472	active site
349163004473	catalytic residue [active]
349163004474	metal binding site [ion binding]; metal-binding site
349163004475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
349163004476	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
349163004477	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
349163004478	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163004479	putative ligand binding site [chemical binding]; other site
349163004480	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
349163004481	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349163004482	Walker A/P-loop; other site
349163004483	ATP binding site [chemical binding]; other site
349163004484	Q-loop/lid; other site
349163004485	ABC transporter signature motif; other site
349163004486	Walker B; other site
349163004487	D-loop; other site
349163004488	H-loop/switch region; other site
349163004489	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349163004490	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163004491	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163004492	TM-ABC transporter signature motif; other site
349163004493	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163004494	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163004495	TM-ABC transporter signature motif; other site
349163004496	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
349163004497	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349163004498	Phosphate transporter family; Region: PHO4; cl00396
349163004499	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
349163004500	Mechanosensitive ion channel; Region: MS_channel; pfam00924
349163004501	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
349163004502	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
349163004503	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
349163004504	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
349163004505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163004506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163004507	fumarylacetoacetase; Region: PLN02856
349163004508	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
349163004509	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
349163004510	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
349163004511	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349163004512	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
349163004513	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163004514	short chain dehydrogenase; Provisional; Region: PRK06181
349163004515	NAD(P) binding site [chemical binding]; other site
349163004516	active site
349163004517	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
349163004518	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
349163004519	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349163004520	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349163004521	Bacterial transcriptional repressor; Region: TetR; pfam13972
349163004522	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
349163004523	tetramer interface [polypeptide binding]; other site
349163004524	active site
349163004525	Mg2+/Mn2+ binding site [ion binding]; other site
349163004526	isocitrate lyase; Region: PLN02892
349163004527	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
349163004528	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
349163004529	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349163004530	DNA binding residues [nucleotide binding]
349163004531	Subunit I/III interface [polypeptide binding]; other site
349163004532	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
349163004533	cytochrome o ubiquinol oxidase, subunit I; Region: CyoB; TIGR02843
349163004534	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
349163004535	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
349163004536	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
349163004537	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
349163004538	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
349163004539	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163004540	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163004541	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349163004542	dimerization interface [polypeptide binding]; other site
349163004543	Methyltransferase domain; Region: Methyltransf_31; pfam13847
349163004544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163004545	S-adenosylmethionine binding site [chemical binding]; other site
349163004546	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349163004547	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
349163004548	catalytic residues [active]
349163004549	catalytic nucleophile [active]
349163004550	Presynaptic Site I dimer interface [polypeptide binding]; other site
349163004551	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
349163004552	Synaptic Flat tetramer interface [polypeptide binding]; other site
349163004553	Synaptic Site I dimer interface [polypeptide binding]; other site
349163004554	DNA binding site [nucleotide binding]
349163004555	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
349163004556	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
349163004557	FOG: CBS domain [General function prediction only]; Region: COG0517
349163004558	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
349163004559	NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007
349163004560	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349163004561	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
349163004562	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349163004563	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
349163004564	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
349163004565	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349163004566	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
349163004567	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
349163004568	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
349163004569	4Fe-4S binding domain; Region: Fer4; pfam00037
349163004570	4Fe-4S binding domain; Region: Fer4; pfam00037
349163004571	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
349163004572	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
349163004573	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163004574	catalytic loop [active]
349163004575	iron binding site [ion binding]; other site
349163004576	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
349163004577	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
349163004578	[4Fe-4S] binding site [ion binding]; other site
349163004579	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
349163004580	molybdopterin cofactor binding site; other site
349163004581	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
349163004582	SLBB domain; Region: SLBB; pfam10531
349163004583	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
349163004584	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
349163004585	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
349163004586	putative dimer interface [polypeptide binding]; other site
349163004587	[2Fe-2S] cluster binding site [ion binding]; other site
349163004588	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
349163004589	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
349163004590	NADH dehydrogenase subunit D; Validated; Region: PRK06075
349163004591	NADH dehydrogenase subunit B; Validated; Region: PRK06411
349163004592	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
349163004593	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
349163004594	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
349163004595	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349163004596	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
349163004597	Soluble P-type ATPase [General function prediction only]; Region: COG4087
349163004598	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
349163004599	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
349163004600	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
349163004601	putative oxidoreductase; Provisional; Region: PRK11579
349163004602	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
349163004603	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
349163004604	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
349163004605	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
349163004606	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349163004607	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349163004608	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
349163004609	putative metal binding site [ion binding]; other site
349163004610	putative homodimer interface [polypeptide binding]; other site
349163004611	putative homotetramer interface [polypeptide binding]; other site
349163004612	putative homodimer-homodimer interface [polypeptide binding]; other site
349163004613	putative allosteric switch controlling residues; other site
349163004614	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
349163004615	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
349163004616	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
349163004617	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
349163004618	DNA binding residues [nucleotide binding]
349163004619	dimer interface [polypeptide binding]; other site
349163004620	putative metal binding site [ion binding]; other site
349163004621	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
349163004622	Cation efflux family; Region: Cation_efflux; cl00316
349163004623	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
349163004624	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
349163004625	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
349163004626	Multicopper oxidase; Region: Cu-oxidase; pfam00394
349163004627	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
349163004628	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
349163004629	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349163004630	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349163004631	substrate binding pocket [chemical binding]; other site
349163004632	membrane-bound complex binding site; other site
349163004633	hinge residues; other site
349163004634	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
349163004635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163004636	dimer interface [polypeptide binding]; other site
349163004637	conserved gate region; other site
349163004638	putative PBP binding loops; other site
349163004639	ABC-ATPase subunit interface; other site
349163004640	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
349163004641	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
349163004642	Walker A/P-loop; other site
349163004643	ATP binding site [chemical binding]; other site
349163004644	Q-loop/lid; other site
349163004645	ABC transporter signature motif; other site
349163004646	Walker B; other site
349163004647	D-loop; other site
349163004648	H-loop/switch region; other site
349163004649	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163004650	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163004651	TM-ABC transporter signature motif; other site
349163004652	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163004653	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163004654	TM-ABC transporter signature motif; other site
349163004655	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
349163004656	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349163004657	Walker A/P-loop; other site
349163004658	ATP binding site [chemical binding]; other site
349163004659	Q-loop/lid; other site
349163004660	ABC transporter signature motif; other site
349163004661	Walker B; other site
349163004662	D-loop; other site
349163004663	H-loop/switch region; other site
349163004664	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349163004665	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
349163004666	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163004667	putative ligand binding site [chemical binding]; other site
349163004668	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
349163004669	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
349163004670	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
349163004671	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
349163004672	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
349163004673	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
349163004674	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
349163004675	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
349163004676	conserved cys residue [active]
349163004677	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349163004678	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349163004679	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349163004680	Zn2+ binding site [ion binding]; other site
349163004681	Mg2+ binding site [ion binding]; other site
349163004682	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
349163004683	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
349163004684	tetramer interface [polypeptide binding]; other site
349163004685	heme binding pocket [chemical binding]; other site
349163004686	NADPH binding site [chemical binding]; other site
349163004687	guanine deaminase; Provisional; Region: PRK09228
349163004688	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
349163004689	active site
349163004690	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
349163004691	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
349163004692	Predicted membrane protein [Function unknown]; Region: COG3748
349163004693	Protein of unknown function (DUF989); Region: DUF989; pfam06181
349163004694	Cytochrome c; Region: Cytochrom_C; pfam00034
349163004695	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
349163004696	active site
349163004697	homotetramer interface [polypeptide binding]; other site
349163004698	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
349163004699	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
349163004700	XdhC Rossmann domain; Region: XdhC_C; pfam13478
349163004701	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
349163004702	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349163004703	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349163004704	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
349163004705	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
349163004706	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
349163004707	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
349163004708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163004709	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
349163004710	putative dimerization interface [polypeptide binding]; other site
349163004711	putative substrate binding pocket [chemical binding]; other site
349163004712	glyoxylate carboligase; Provisional; Region: PRK11269
349163004713	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
349163004714	PYR/PP interface [polypeptide binding]; other site
349163004715	dimer interface [polypeptide binding]; other site
349163004716	TPP binding site [chemical binding]; other site
349163004717	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349163004718	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
349163004719	TPP-binding site [chemical binding]; other site
349163004720	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
349163004721	tartronate semialdehyde reductase; Provisional; Region: PRK15059
349163004722	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
349163004723	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
349163004724	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
349163004725	MOFRL family; Region: MOFRL; pfam05161
349163004726	allantoate amidohydrolase; Reviewed; Region: PRK09290
349163004727	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
349163004728	active site
349163004729	metal binding site [ion binding]; metal-binding site
349163004730	dimer interface [polypeptide binding]; other site
349163004731	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
349163004732	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
349163004733	metal binding site [ion binding]; metal-binding site
349163004734	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
349163004735	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
349163004736	active site
349163004737	catalytic site [active]
349163004738	tetramer interface [polypeptide binding]; other site
349163004739	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163004740	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163004741	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463
349163004742	putative substrate binding pocket [chemical binding]; other site
349163004743	putative dimerization interface [polypeptide binding]; other site
349163004744	Hint domain; Region: Hint_2; pfam13403
349163004745	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
349163004746	active site
349163004747	Int/Topo IB signature motif; other site
349163004748	AAA domain; Region: AAA_25; pfam13481
349163004749	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349163004750	ATP binding site [chemical binding]; other site
349163004751	Walker A motif; other site
349163004752	Walker B motif; other site
349163004753	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
349163004754	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
349163004755	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
349163004756	active site
349163004757	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
349163004758	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
349163004759	active site
349163004760	(T/H)XGH motif; other site
349163004761	DNA gyrase subunit A; Validated; Region: PRK05560
349163004762	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
349163004763	CAP-like domain; other site
349163004764	active site
349163004765	primary dimer interface [polypeptide binding]; other site
349163004766	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349163004767	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349163004768	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349163004769	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349163004770	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
349163004771	substrate binding pocket [chemical binding]; other site
349163004772	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
349163004773	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
349163004774	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
349163004775	Preprotein translocase subunit; Region: YajC; pfam02699
349163004776	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
349163004777	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163004778	Walker A motif; other site
349163004779	ATP binding site [chemical binding]; other site
349163004780	Walker B motif; other site
349163004781	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
349163004782	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
349163004783	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
349163004784	peptide binding site [polypeptide binding]; other site
349163004785	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
349163004786	dimer interface [polypeptide binding]; other site
349163004787	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
349163004788	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163004789	dimer interface [polypeptide binding]; other site
349163004790	conserved gate region; other site
349163004791	putative PBP binding loops; other site
349163004792	ABC-ATPase subunit interface; other site
349163004793	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
349163004794	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
349163004795	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349163004796	Walker A/P-loop; other site
349163004797	ATP binding site [chemical binding]; other site
349163004798	Q-loop/lid; other site
349163004799	ABC transporter signature motif; other site
349163004800	Walker B; other site
349163004801	D-loop; other site
349163004802	H-loop/switch region; other site
349163004803	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
349163004804	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
349163004805	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349163004806	Walker A/P-loop; other site
349163004807	ATP binding site [chemical binding]; other site
349163004808	Q-loop/lid; other site
349163004809	ABC transporter signature motif; other site
349163004810	Walker B; other site
349163004811	D-loop; other site
349163004812	H-loop/switch region; other site
349163004813	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
349163004814	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
349163004815	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
349163004816	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
349163004817	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349163004818	active site
349163004819	DNA binding site [nucleotide binding]
349163004820	Int/Topo IB signature motif; other site
349163004821	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349163004822	Coenzyme A binding pocket [chemical binding]; other site
349163004823	ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563
349163004824	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163004825	S-adenosylmethionine binding site [chemical binding]; other site
349163004826	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
349163004827	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
349163004828	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
349163004829	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
349163004830	active site
349163004831	acyl-CoA synthetase; Validated; Region: PRK08162
349163004832	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
349163004833	acyl-activating enzyme (AAE) consensus motif; other site
349163004834	putative active site [active]
349163004835	AMP binding site [chemical binding]; other site
349163004836	putative CoA binding site [chemical binding]; other site
349163004837	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
349163004838	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349163004839	active site
349163004840	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
349163004841	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
349163004842	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
349163004843	substrate binding pocket [chemical binding]; other site
349163004844	chain length determination region; other site
349163004845	substrate-Mg2+ binding site; other site
349163004846	catalytic residues [active]
349163004847	aspartate-rich region 1; other site
349163004848	active site lid residues [active]
349163004849	aspartate-rich region 2; other site
349163004850	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
349163004851	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
349163004852	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
349163004853	putative active site [active]
349163004854	Zn binding site [ion binding]; other site
349163004855	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
349163004856	CPxP  motif; other site
349163004857	fructokinase; Reviewed; Region: PRK09557
349163004858	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
349163004859	nucleotide binding site [chemical binding]; other site
349163004860	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
349163004861	active site
349163004862	multifunctional aminopeptidase A; Provisional; Region: PRK00913
349163004863	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
349163004864	interface (dimer of trimers) [polypeptide binding]; other site
349163004865	Substrate-binding/catalytic site; other site
349163004866	Zn-binding sites [ion binding]; other site
349163004867	Protein of unknown function (DUF563); Region: DUF563; pfam04577
349163004868	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
349163004869	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
349163004870	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
349163004871	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
349163004872	CAP-like domain; other site
349163004873	active site
349163004874	primary dimer interface [polypeptide binding]; other site
349163004875	Recombination protein O N terminal; Region: RecO_N; pfam11967
349163004876	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
349163004877	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
349163004878	metal binding site [ion binding]; metal-binding site
349163004879	putative dimer interface [polypeptide binding]; other site
349163004880	Transposase; Region: HTH_Tnp_1; cl17663
349163004881	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
349163004882	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
349163004883	NAD binding site [chemical binding]; other site
349163004884	substrate binding site [chemical binding]; other site
349163004885	homodimer interface [polypeptide binding]; other site
349163004886	active site
349163004887	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
349163004888	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
349163004889	substrate binding site; other site
349163004890	tetramer interface; other site
349163004891	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
349163004892	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
349163004893	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163004894	active site
349163004895	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349163004896	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349163004897	active site
349163004898	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
349163004899	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
349163004900	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
349163004901	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
349163004902	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
349163004903	TPP-binding site [chemical binding]; other site
349163004904	dimer interface [polypeptide binding]; other site
349163004905	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
349163004906	PYR/PP interface [polypeptide binding]; other site
349163004907	dimer interface [polypeptide binding]; other site
349163004908	TPP binding site [chemical binding]; other site
349163004909	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
349163004910	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
349163004911	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
349163004912	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
349163004913	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
349163004914	Phosphoglycerate kinase; Region: PGK; pfam00162
349163004915	substrate binding site [chemical binding]; other site
349163004916	hinge regions; other site
349163004917	ADP binding site [chemical binding]; other site
349163004918	catalytic site [active]
349163004919	protease TldD; Provisional; Region: tldD; PRK10735
349163004920	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
349163004921	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
349163004922	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
349163004923	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
349163004924	transcription termination factor Rho; Provisional; Region: rho; PRK09376
349163004925	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
349163004926	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
349163004927	RNA binding site [nucleotide binding]; other site
349163004928	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
349163004929	multimer interface [polypeptide binding]; other site
349163004930	Walker A motif; other site
349163004931	ATP binding site [chemical binding]; other site
349163004932	Walker B motif; other site
349163004933	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
349163004934	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
349163004935	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
349163004936	homotetramer interface [polypeptide binding]; other site
349163004937	ligand binding site [chemical binding]; other site
349163004938	catalytic site [active]
349163004939	NAD binding site [chemical binding]; other site
349163004940	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
349163004941	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
349163004942	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
349163004943	dimer interface [polypeptide binding]; other site
349163004944	putative functional site; other site
349163004945	putative MPT binding site; other site
349163004946	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
349163004947	trimer interface [polypeptide binding]; other site
349163004948	dimer interface [polypeptide binding]; other site
349163004949	putative active site [active]
349163004950	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
349163004951	active site
349163004952	ribulose/triose binding site [chemical binding]; other site
349163004953	phosphate binding site [ion binding]; other site
349163004954	substrate (anthranilate) binding pocket [chemical binding]; other site
349163004955	product (indole) binding pocket [chemical binding]; other site
349163004956	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
349163004957	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
349163004958	glutamine binding [chemical binding]; other site
349163004959	catalytic triad [active]
349163004960	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
349163004961	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
349163004962	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
349163004963	anthranilate synthase component I; Provisional; Region: PRK13573
349163004964	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
349163004965	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
349163004966	SurA N-terminal domain; Region: SurA_N_3; cl07813
349163004967	periplasmic folding chaperone; Provisional; Region: PRK10788
349163004968	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
349163004969	triosephosphate isomerase; Provisional; Region: PRK14565
349163004970	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
349163004971	substrate binding site [chemical binding]; other site
349163004972	dimer interface [polypeptide binding]; other site
349163004973	catalytic triad [active]
349163004974	CTP synthetase; Validated; Region: pyrG; PRK05380
349163004975	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
349163004976	Catalytic site [active]
349163004977	active site
349163004978	UTP binding site [chemical binding]; other site
349163004979	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
349163004980	active site
349163004981	putative oxyanion hole; other site
349163004982	catalytic triad [active]
349163004983	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
349163004984	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
349163004985	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
349163004986	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
349163004987	FAD binding pocket [chemical binding]; other site
349163004988	FAD binding motif [chemical binding]; other site
349163004989	phosphate binding motif [ion binding]; other site
349163004990	beta-alpha-beta structure motif; other site
349163004991	NAD binding pocket [chemical binding]; other site
349163004992	malate synthase G; Provisional; Region: PRK02999
349163004993	active site
349163004994	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
349163004995	heme-binding site [chemical binding]; other site
349163004996	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
349163004997	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163004998	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
349163004999	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
349163005000	YceI-like domain; Region: YceI; smart00867
349163005001	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
349163005002	choline dehydrogenase; Validated; Region: PRK02106
349163005003	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
349163005004	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
349163005005	Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134
349163005006	NAD(P) binding site [chemical binding]; other site
349163005007	catalytic residues [active]
349163005008	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
349163005009	active site 2 [active]
349163005010	active site 1 [active]
349163005011	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
349163005012	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349163005013	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
349163005014	acyl-activating enzyme (AAE) consensus motif; other site
349163005015	putative AMP binding site [chemical binding]; other site
349163005016	putative active site [active]
349163005017	putative CoA binding site [chemical binding]; other site
349163005018	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
349163005019	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
349163005020	dimer interface [polypeptide binding]; other site
349163005021	active site
349163005022	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
349163005023	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
349163005024	active site 1 [active]
349163005025	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
349163005026	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163005027	NAD(P) binding site [chemical binding]; other site
349163005028	active site
349163005029	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
349163005030	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349163005031	active site
349163005032	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
349163005033	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
349163005034	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163005035	catalytic loop [active]
349163005036	iron binding site [ion binding]; other site
349163005037	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD...; Region: oxygenase_e_transfer_subunit; cd06213
349163005038	FAD binding pocket [chemical binding]; other site
349163005039	FAD binding motif [chemical binding]; other site
349163005040	phosphate binding motif [ion binding]; other site
349163005041	beta-alpha-beta structure motif; other site
349163005042	NAD binding pocket [chemical binding]; other site
349163005043	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
349163005044	Fatty acid desaturase; Region: FA_desaturase; pfam00487
349163005045	Di-iron ligands [ion binding]; other site
349163005046	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
349163005047	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
349163005048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
349163005049	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
349163005050	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349163005051	DNA-binding site [nucleotide binding]; DNA binding site
349163005052	FCD domain; Region: FCD; pfam07729
349163005053	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
349163005054	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349163005055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163005056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163005057	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
349163005058	tartrate dehydrogenase; Region: TTC; TIGR02089
349163005059	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
349163005060	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
349163005061	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
349163005062	tetramer (dimer of dimers) interface [polypeptide binding]; other site
349163005063	active site
349163005064	dimer interface [polypeptide binding]; other site
349163005065	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
349163005066	AAA domain; Region: AAA_33; pfam13671
349163005067	ATP-binding site [chemical binding]; other site
349163005068	Gluconate-6-phosphate binding site [chemical binding]; other site
349163005069	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
349163005070	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
349163005071	putative active site [active]
349163005072	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349163005073	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
349163005074	active site
349163005075	motif I; other site
349163005076	motif II; other site
349163005077	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
349163005078	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
349163005079	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
349163005080	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
349163005081	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
349163005082	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
349163005083	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
349163005084	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
349163005085	putative active site [active]
349163005086	catalytic residue [active]
349163005087	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
349163005088	active site
349163005089	dimer interface [polypeptide binding]; other site
349163005090	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
349163005091	GTP-binding protein LepA; Provisional; Region: PRK05433
349163005092	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
349163005093	G1 box; other site
349163005094	putative GEF interaction site [polypeptide binding]; other site
349163005095	GTP/Mg2+ binding site [chemical binding]; other site
349163005096	Switch I region; other site
349163005097	G2 box; other site
349163005098	G3 box; other site
349163005099	Switch II region; other site
349163005100	G4 box; other site
349163005101	G5 box; other site
349163005102	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
349163005103	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
349163005104	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
349163005105	RmuC family; Region: RmuC; pfam02646
349163005106	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
349163005107	Immunity protein Imm5; Region: Imm5; pfam14423
349163005108	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349163005109	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349163005110	Predicted membrane protein [Function unknown]; Region: COG2259
349163005111	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163005112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163005113	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349163005114	putative effector binding pocket; other site
349163005115	dimerization interface [polypeptide binding]; other site
349163005116	Transposase; Region: HTH_Tnp_1; cl17663
349163005117	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
349163005118	HTH-like domain; Region: HTH_21; pfam13276
349163005119	Integrase core domain; Region: rve; pfam00665
349163005120	putative transposase OrfB; Reviewed; Region: PHA02517
349163005121	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163005122	PAS domain; Region: PAS_9; pfam13426
349163005123	putative active site [active]
349163005124	heme pocket [chemical binding]; other site
349163005125	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163005126	PAS domain; Region: PAS_9; pfam13426
349163005127	putative active site [active]
349163005128	heme pocket [chemical binding]; other site
349163005129	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349163005130	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349163005131	dimer interface [polypeptide binding]; other site
349163005132	putative CheW interface [polypeptide binding]; other site
349163005133	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
349163005134	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
349163005135	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
349163005136	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
349163005137	DXD motif; other site
349163005138	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349163005139	active site
349163005140	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349163005141	TPR motif; other site
349163005142	binding surface
349163005143	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163005144	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163005145	Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608
349163005146	DHH family; Region: DHH; pfam01368
349163005147	DHHA1 domain; Region: DHHA1; pfam02272
349163005148	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
349163005149	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
349163005150	putative active site [active]
349163005151	homoserine dehydrogenase; Provisional; Region: PRK06349
349163005152	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
349163005153	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
349163005154	aminotransferase; Validated; Region: PRK09148
349163005155	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349163005156	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163005157	homodimer interface [polypeptide binding]; other site
349163005158	catalytic residue [active]
349163005159	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
349163005160	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
349163005161	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349163005162	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163005163	O-Antigen ligase; Region: Wzy_C; pfam04932
349163005164	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
349163005165	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
349163005166	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
349163005167	P-loop, Walker A motif; other site
349163005168	Base recognition motif; other site
349163005169	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
349163005170	FOG: WD40 repeat [General function prediction only]; Region: COG2319
349163005171	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
349163005172	structural tetrad; other site
349163005173	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349163005174	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349163005175	active site
349163005176	catalytic tetrad [active]
349163005177	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
349163005178	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
349163005179	G1 box; other site
349163005180	putative GEF interaction site [polypeptide binding]; other site
349163005181	GTP/Mg2+ binding site [chemical binding]; other site
349163005182	Switch I region; other site
349163005183	G2 box; other site
349163005184	G3 box; other site
349163005185	Switch II region; other site
349163005186	G4 box; other site
349163005187	G5 box; other site
349163005188	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
349163005189	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
349163005190	muropeptide transporter; Reviewed; Region: ampG; PRK11902
349163005191	muropeptide transporter; Validated; Region: ampG; cl17669
349163005192	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
349163005193	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349163005194	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349163005195	ABC transporter; Region: ABC_tran_2; pfam12848
349163005196	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349163005197	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
349163005198	active site
349163005199	multimer interface [polypeptide binding]; other site
349163005200	rod shape-determining protein MreB; Provisional; Region: PRK13927
349163005201	MreB and similar proteins; Region: MreB_like; cd10225
349163005202	nucleotide binding site [chemical binding]; other site
349163005203	Mg binding site [ion binding]; other site
349163005204	putative protofilament interaction site [polypeptide binding]; other site
349163005205	RodZ interaction site [polypeptide binding]; other site
349163005206	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349163005207	Ligand Binding Site [chemical binding]; other site
349163005208	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
349163005209	MarR family; Region: MarR; pfam01047
349163005210	Pirin-related protein [General function prediction only]; Region: COG1741
349163005211	Pirin; Region: Pirin; pfam02678
349163005212	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
349163005213	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
349163005214	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349163005215	protein binding site [polypeptide binding]; other site
349163005216	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349163005217	protein binding site [polypeptide binding]; other site
349163005218	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
349163005219	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
349163005220	Active Sites [active]
349163005221	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
349163005222	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
349163005223	CysD dimerization site [polypeptide binding]; other site
349163005224	G1 box; other site
349163005225	putative GEF interaction site [polypeptide binding]; other site
349163005226	GTP/Mg2+ binding site [chemical binding]; other site
349163005227	Switch I region; other site
349163005228	G2 box; other site
349163005229	G3 box; other site
349163005230	Switch II region; other site
349163005231	G4 box; other site
349163005232	G5 box; other site
349163005233	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
349163005234	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
349163005235	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
349163005236	ligand-binding site [chemical binding]; other site
349163005237	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
349163005238	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
349163005239	Tetramer interface [polypeptide binding]; other site
349163005240	active site
349163005241	FMN-binding site [chemical binding]; other site
349163005242	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349163005243	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345
349163005244	putative ligand binding site [chemical binding]; other site
349163005245	Domain of unknown function (DUF336); Region: DUF336; cl01249
349163005246	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
349163005247	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349163005248	protein binding site [polypeptide binding]; other site
349163005249	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
349163005250	protein binding site [polypeptide binding]; other site
349163005251	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
349163005252	active site
349163005253	HIGH motif; other site
349163005254	nucleotide binding site [chemical binding]; other site
349163005255	putative hydrolase; Provisional; Region: PRK11460
349163005256	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
349163005257	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
349163005258	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
349163005259	active site
349163005260	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
349163005261	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
349163005262	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163005263	catalytic residue [active]
349163005264	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
349163005265	substrate binding site [chemical binding]; other site
349163005266	active site
349163005267	catalytic residues [active]
349163005268	heterodimer interface [polypeptide binding]; other site
349163005269	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
349163005270	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
349163005271	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349163005272	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
349163005273	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
349163005274	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
349163005275	generic binding surface II; other site
349163005276	generic binding surface I; other site
349163005277	Anti-sigma-K factor rskA; Region: RskA; pfam10099
349163005278	RNA polymerase sigma factor; Provisional; Region: PRK12537
349163005279	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349163005280	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349163005281	DNA binding residues [nucleotide binding]
349163005282	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
349163005283	metal binding site 2 [ion binding]; metal-binding site
349163005284	putative DNA binding helix; other site
349163005285	metal binding site 1 [ion binding]; metal-binding site
349163005286	dimer interface [polypeptide binding]; other site
349163005287	structural Zn2+ binding site [ion binding]; other site
349163005288	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
349163005289	Stringent starvation protein B; Region: SspB; pfam04386
349163005290	fumarate hydratase; Provisional; Region: PRK15389
349163005291	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
349163005292	Fumarase C-terminus; Region: Fumerase_C; pfam05683
349163005293	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
349163005294	dimer interface [polypeptide binding]; other site
349163005295	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349163005296	metal binding site [ion binding]; metal-binding site
349163005297	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
349163005298	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
349163005299	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
349163005300	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
349163005301	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
349163005302	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
349163005303	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
349163005304	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
349163005305	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
349163005306	LrgB-like family; Region: LrgB; cl00596
349163005307	LrgA family; Region: LrgA; pfam03788
349163005308	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163005309	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163005310	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349163005311	putative effector binding pocket; other site
349163005312	dimerization interface [polypeptide binding]; other site
349163005313	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
349163005314	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349163005315	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
349163005316	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
349163005317	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163005318	S-adenosylmethionine binding site [chemical binding]; other site
349163005319	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
349163005320	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349163005321	Methyltransferase domain; Region: Methyltransf_11; pfam08241
349163005322	Rhamnan synthesis protein F; Region: RgpF; pfam05045
349163005323	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
349163005324	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
349163005325	putative acyl-acceptor binding pocket; other site
349163005326	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
349163005327	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
349163005328	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163005329	FeS/SAM binding site; other site
349163005330	TRAM domain; Region: TRAM; pfam01938
349163005331	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
349163005332	PhoH-like protein; Region: PhoH; pfam02562
349163005333	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
349163005334	FOG: CBS domain [General function prediction only]; Region: COG0517
349163005335	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
349163005336	Transporter associated domain; Region: CorC_HlyC; smart01091
349163005337	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
349163005338	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
349163005339	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349163005340	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163005341	Walker A/P-loop; other site
349163005342	ATP binding site [chemical binding]; other site
349163005343	Q-loop/lid; other site
349163005344	ABC transporter signature motif; other site
349163005345	Walker B; other site
349163005346	D-loop; other site
349163005347	H-loop/switch region; other site
349163005348	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
349163005349	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163005350	putative ADP-binding pocket [chemical binding]; other site
349163005351	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163005352	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163005353	Walker A/P-loop; other site
349163005354	ATP binding site [chemical binding]; other site
349163005355	Q-loop/lid; other site
349163005356	ABC transporter signature motif; other site
349163005357	Walker B; other site
349163005358	D-loop; other site
349163005359	H-loop/switch region; other site
349163005360	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163005361	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163005362	TM-ABC transporter signature motif; other site
349163005363	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
349163005364	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163005365	putative ligand binding site [chemical binding]; other site
349163005366	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
349163005367	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
349163005368	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349163005369	AlkA N-terminal domain; Region: AlkA_N; pfam06029
349163005370	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
349163005371	minor groove reading motif; other site
349163005372	helix-hairpin-helix signature motif; other site
349163005373	active site
349163005374	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
349163005375	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
349163005376	DNA binding site [nucleotide binding]
349163005377	active site
349163005378	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
349163005379	homodimer interface [polypeptide binding]; other site
349163005380	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163005381	catalytic residue [active]
349163005382	Tic20-like protein; Region: Tic20; pfam09685
349163005383	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
349163005384	GAF domain; Region: GAF; pfam01590
349163005385	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163005386	Walker A motif; other site
349163005387	ATP binding site [chemical binding]; other site
349163005388	Walker B motif; other site
349163005389	arginine finger; other site
349163005390	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349163005391	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
349163005392	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
349163005393	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
349163005394	active site
349163005395	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
349163005396	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
349163005397	dimerization interface [polypeptide binding]; other site
349163005398	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
349163005399	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163005400	catalytic loop [active]
349163005401	iron binding site [ion binding]; other site
349163005402	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
349163005403	FAD binding pocket [chemical binding]; other site
349163005404	conserved FAD binding motif [chemical binding]; other site
349163005405	phosphate binding motif [ion binding]; other site
349163005406	beta-alpha-beta structure motif; other site
349163005407	NAD binding pocket [chemical binding]; other site
349163005408	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
349163005409	dimerization interface [polypeptide binding]; other site
349163005410	putative path to active site cavity [active]
349163005411	diiron center [ion binding]; other site
349163005412	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
349163005413	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
349163005414	dimer interface [polypeptide binding]; other site
349163005415	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349163005416	active site
349163005417	metal binding site [ion binding]; metal-binding site
349163005418	glutathione binding site [chemical binding]; other site
349163005419	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
349163005420	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
349163005421	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349163005422	catalytic residues [active]
349163005423	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
349163005424	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349163005425	active site residue [active]
349163005426	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349163005427	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349163005428	HlyD family secretion protein; Region: HlyD_3; pfam13437
349163005429	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349163005430	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163005431	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349163005432	non-specific DNA binding site [nucleotide binding]; other site
349163005433	salt bridge; other site
349163005434	sequence-specific DNA binding site [nucleotide binding]; other site
349163005435	hydrogenase 4 subunit B; Validated; Region: PRK06521
349163005436	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349163005437	NADH dehydrogenase; Region: NADHdh; cl00469
349163005438	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
349163005439	hydrogenase 4 subunit F; Validated; Region: PRK06458
349163005440	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349163005441	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
349163005442	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
349163005443	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
349163005444	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
349163005445	Ferritin-like domain; Region: Ferritin; pfam00210
349163005446	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
349163005447	dinuclear metal binding motif [ion binding]; other site
349163005448	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
349163005449	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
349163005450	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
349163005451	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
349163005452	active site
349163005453	HIGH motif; other site
349163005454	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
349163005455	KMSKS motif; other site
349163005456	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
349163005457	tRNA binding surface [nucleotide binding]; other site
349163005458	anticodon binding site; other site
349163005459	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
349163005460	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
349163005461	acetylornithine deacetylase; Provisional; Region: PRK06837
349163005462	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
349163005463	metal binding site [ion binding]; metal-binding site
349163005464	dimer interface [polypeptide binding]; other site
349163005465	amidase; Provisional; Region: PRK07487
349163005466	Amidase; Region: Amidase; cl11426
349163005467	Short C-terminal domain; Region: SHOCT; pfam09851
349163005468	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
349163005469	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163005470	Walker A motif; other site
349163005471	ATP binding site [chemical binding]; other site
349163005472	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
349163005473	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
349163005474	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
349163005475	active site
349163005476	HslU subunit interaction site [polypeptide binding]; other site
349163005477	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
349163005478	benzoate transport; Region: 2A0115; TIGR00895
349163005479	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163005480	putative substrate translocation pore; other site
349163005481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163005482	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
349163005483	4-fold oligomerization interface [polypeptide binding]; other site
349163005484	putative active site pocket [active]
349163005485	metal binding residues [ion binding]; metal-binding site
349163005486	3-fold/trimer interface [polypeptide binding]; other site
349163005487	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
349163005488	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
349163005489	putative active site [active]
349163005490	oxyanion strand; other site
349163005491	catalytic triad [active]
349163005492	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349163005493	Coenzyme A binding pocket [chemical binding]; other site
349163005494	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
349163005495	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
349163005496	catalytic residues [active]
349163005497	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
349163005498	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
349163005499	substrate binding site [chemical binding]; other site
349163005500	glutamase interaction surface [polypeptide binding]; other site
349163005501	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
349163005502	metal binding site [ion binding]; metal-binding site
349163005503	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
349163005504	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
349163005505	active site
349163005506	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
349163005507	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
349163005508	putative active site [active]
349163005509	Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism; Region: HOT; cd08190
349163005510	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
349163005511	putative active site [active]
349163005512	metal binding site [ion binding]; metal-binding site
349163005513	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
349163005514	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
349163005515	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163005516	NAD(P) binding site [chemical binding]; other site
349163005517	active site
349163005518	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
349163005519	short chain dehydrogenase; Provisional; Region: PRK06125
349163005520	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163005521	NAD(P) binding site [chemical binding]; other site
349163005522	active site
349163005523	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
349163005524	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163005525	NAD(P) binding site [chemical binding]; other site
349163005526	active site
349163005527	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
349163005528	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349163005529	acyl-activating enzyme (AAE) consensus motif; other site
349163005530	AMP binding site [chemical binding]; other site
349163005531	active site
349163005532	CoA binding site [chemical binding]; other site
349163005533	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
349163005534	FtsH Extracellular; Region: FtsH_ext; pfam06480
349163005535	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
349163005536	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163005537	Walker A motif; other site
349163005538	ATP binding site [chemical binding]; other site
349163005539	Walker B motif; other site
349163005540	arginine finger; other site
349163005541	Peptidase family M41; Region: Peptidase_M41; pfam01434
349163005542	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
349163005543	putative catalytic site [active]
349163005544	putative metal binding site [ion binding]; other site
349163005545	putative phosphate binding site [ion binding]; other site
349163005546	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
349163005547	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
349163005548	putative active site [active]
349163005549	catalytic site [active]
349163005550	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
349163005551	putative active site [active]
349163005552	catalytic site [active]
349163005553	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349163005554	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
349163005555	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
349163005556	substrate binding pocket [chemical binding]; other site
349163005557	chain length determination region; other site
349163005558	substrate-Mg2+ binding site; other site
349163005559	catalytic residues [active]
349163005560	aspartate-rich region 1; other site
349163005561	active site lid residues [active]
349163005562	aspartate-rich region 2; other site
349163005563	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
349163005564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163005565	Protein required for attachment to host cells; Region: Host_attach; pfam10116
349163005566	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
349163005567	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
349163005568	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
349163005569	DNA polymerase III subunit beta; Validated; Region: PRK05643
349163005570	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
349163005571	putative DNA binding surface [nucleotide binding]; other site
349163005572	dimer interface [polypeptide binding]; other site
349163005573	beta-clamp/clamp loader binding surface; other site
349163005574	beta-clamp/translesion DNA polymerase binding surface; other site
349163005575	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
349163005576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163005577	dimer interface [polypeptide binding]; other site
349163005578	putative PBP binding loops; other site
349163005579	ABC-ATPase subunit interface; other site
349163005580	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163005581	dimer interface [polypeptide binding]; other site
349163005582	conserved gate region; other site
349163005583	putative PBP binding loops; other site
349163005584	ABC-ATPase subunit interface; other site
349163005585	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
349163005586	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
349163005587	Walker A/P-loop; other site
349163005588	ATP binding site [chemical binding]; other site
349163005589	Q-loop/lid; other site
349163005590	ABC transporter signature motif; other site
349163005591	Walker B; other site
349163005592	D-loop; other site
349163005593	H-loop/switch region; other site
349163005594	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
349163005595	fumarate hydratase; Reviewed; Region: fumC; PRK00485
349163005596	Class II fumarases; Region: Fumarase_classII; cd01362
349163005597	active site
349163005598	tetramer interface [polypeptide binding]; other site
349163005599	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163005600	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163005601	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349163005602	dimerization interface [polypeptide binding]; other site
349163005603	Predicted membrane protein [Function unknown]; Region: COG2259
349163005604	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
349163005605	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
349163005606	putative active site [active]
349163005607	metal binding site [ion binding]; metal-binding site
349163005608	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163005609	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
349163005610	Na binding site [ion binding]; other site
349163005611	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
349163005612	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
349163005613	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
349163005614	catalytic site [active]
349163005615	G-X2-G-X-G-K; other site
349163005616	hypothetical protein; Provisional; Region: PRK11820
349163005617	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
349163005618	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
349163005619	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
349163005620	DNA methylase; Region: N6_N4_Mtase; pfam01555
349163005621	enoyl-CoA hydratase; Provisional; Region: PRK05862
349163005622	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349163005623	substrate binding site [chemical binding]; other site
349163005624	oxyanion hole (OAH) forming residues; other site
349163005625	trimer interface [polypeptide binding]; other site
349163005626	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
349163005627	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349163005628	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
349163005629	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
349163005630	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
349163005631	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349163005632	Family description; Region: UvrD_C_2; pfam13538
349163005633	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
349163005634	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
349163005635	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349163005636	catalytic residues [active]
349163005637	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
349163005638	benzoate transport; Region: 2A0115; TIGR00895
349163005639	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163005640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163005641	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349163005642	active site
349163005643	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349163005644	catalytic tetrad [active]
349163005645	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
349163005646	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
349163005647	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
349163005648	FAD binding domain; Region: FAD_binding_4; pfam01565
349163005649	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
349163005650	putative active site [active]
349163005651	metal binding site [ion binding]; metal-binding site
349163005652	homodimer binding site [polypeptide binding]; other site
349163005653	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
349163005654	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
349163005655	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
349163005656	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
349163005657	ADP binding site [chemical binding]; other site
349163005658	magnesium binding site [ion binding]; other site
349163005659	putative shikimate binding site; other site
349163005660	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
349163005661	active site
349163005662	dimer interface [polypeptide binding]; other site
349163005663	metal binding site [ion binding]; metal-binding site
349163005664	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
349163005665	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349163005666	active site
349163005667	DNA binding site [nucleotide binding]
349163005668	Int/Topo IB signature motif; other site
349163005669	septum site-determining protein MinD; Region: minD_bact; TIGR01968
349163005670	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349163005671	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
349163005672	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349163005673	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
349163005674	FHIPEP family; Region: FHIPEP; pfam00771
349163005675	acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361
349163005676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163005677	Walker A motif; other site
349163005678	ATP binding site [chemical binding]; other site
349163005679	Walker B motif; other site
349163005680	arginine finger; other site
349163005681	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349163005682	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
349163005683	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
349163005684	FliG C-terminal domain; Region: FliG_C; pfam01706
349163005685	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
349163005686	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
349163005687	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
349163005688	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
349163005689	nucleoside/Zn binding site; other site
349163005690	dimer interface [polypeptide binding]; other site
349163005691	catalytic motif [active]
349163005692	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
349163005693	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
349163005694	catalytic triad [active]
349163005695	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
349163005696	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349163005697	RNA binding surface [nucleotide binding]; other site
349163005698	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
349163005699	active site
349163005700	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
349163005701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349163005702	S-adenosylmethionine binding site [chemical binding]; other site
349163005703	Methyltransferase domain; Region: Methyltransf_24; pfam13578
349163005704	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
349163005705	ABC1 family; Region: ABC1; cl17513
349163005706	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
349163005707	active site
349163005708	ATP binding site [chemical binding]; other site
349163005709	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
349163005710	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
349163005711	active site
349163005712	Zn binding site [ion binding]; other site
349163005713	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
349163005714	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
349163005715	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
349163005716	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
349163005717	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
349163005718	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
349163005719	putative mechanosensitive channel protein; Provisional; Region: PRK11465
349163005720	Mechanosensitive ion channel; Region: MS_channel; pfam00924
349163005721	Biofilm formation and stress response factor; Region: BsmA; pfam10014
349163005722	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
349163005723	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
349163005724	dimer interface [polypeptide binding]; other site
349163005725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163005726	catalytic residue [active]
349163005727	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
349163005728	active site residue [active]
349163005729	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163005730	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
349163005731	active site
349163005732	hypothetical protein; Reviewed; Region: PRK00024
349163005733	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
349163005734	MPN+ (JAMM) motif; other site
349163005735	Zinc-binding site [ion binding]; other site
349163005736	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349163005737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163005738	S-adenosylmethionine binding site [chemical binding]; other site
349163005739	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
349163005740	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349163005741	active site
349163005742	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
349163005743	GSH binding site [chemical binding]; other site
349163005744	catalytic residues [active]
349163005745	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
349163005746	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
349163005747	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
349163005748	trimer interface [polypeptide binding]; other site
349163005749	putative metal binding site [ion binding]; other site
349163005750	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349163005751	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163005752	non-specific DNA binding site [nucleotide binding]; other site
349163005753	salt bridge; other site
349163005754	sequence-specific DNA binding site [nucleotide binding]; other site
349163005755	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
349163005756	Domain of unknown function (DUF955); Region: DUF955; pfam06114
349163005757	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
349163005758	isocitrate lyase; Provisional; Region: PRK15063
349163005759	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
349163005760	tetramer interface [polypeptide binding]; other site
349163005761	active site
349163005762	Mg2+/Mn2+ binding site [ion binding]; other site
349163005763	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
349163005764	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
349163005765	minor groove reading motif; other site
349163005766	helix-hairpin-helix signature motif; other site
349163005767	substrate binding pocket [chemical binding]; other site
349163005768	active site
349163005769	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
349163005770	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
349163005771	DNA binding and oxoG recognition site [nucleotide binding]
349163005772	DNA polymerase I; Provisional; Region: PRK05755
349163005773	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
349163005774	active site
349163005775	metal binding site 1 [ion binding]; metal-binding site
349163005776	putative 5' ssDNA interaction site; other site
349163005777	metal binding site 3; metal-binding site
349163005778	metal binding site 2 [ion binding]; metal-binding site
349163005779	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
349163005780	putative DNA binding site [nucleotide binding]; other site
349163005781	putative metal binding site [ion binding]; other site
349163005782	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
349163005783	active site
349163005784	catalytic site [active]
349163005785	substrate binding site [chemical binding]; other site
349163005786	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
349163005787	active site
349163005788	DNA binding site [nucleotide binding]
349163005789	catalytic site [active]
349163005790	Zinc-finger domain; Region: zf-CHCC; pfam10276
349163005791	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
349163005792	trimer interface [polypeptide binding]; other site
349163005793	active site
349163005794	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
349163005795	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
349163005796	hinge; other site
349163005797	active site
349163005798	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
349163005799	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163005800	S-adenosylmethionine binding site [chemical binding]; other site
349163005801	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
349163005802	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
349163005803	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
349163005804	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
349163005805	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
349163005806	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
349163005807	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
349163005808	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349163005809	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349163005810	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
349163005811	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
349163005812	carboxyltransferase (CT) interaction site; other site
349163005813	biotinylation site [posttranslational modification]; other site
349163005814	enoyl-CoA hydratase; Provisional; Region: PRK05995
349163005815	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349163005816	substrate binding site [chemical binding]; other site
349163005817	oxyanion hole (OAH) forming residues; other site
349163005818	trimer interface [polypeptide binding]; other site
349163005819	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
349163005820	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
349163005821	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
349163005822	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
349163005823	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
349163005824	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349163005825	active site
349163005826	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
349163005827	Acyltransferase family; Region: Acyl_transf_3; pfam01757
349163005828	Chain length determinant protein; Region: Wzz; cl15801
349163005829	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
349163005830	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
349163005831	SLBB domain; Region: SLBB; pfam10531
349163005832	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
349163005833	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
349163005834	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
349163005835	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163005836	NAD(P) binding site [chemical binding]; other site
349163005837	active site
349163005838	acyl carrier protein; Provisional; Region: acpP; PRK00982
349163005839	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
349163005840	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
349163005841	dimer interface [polypeptide binding]; other site
349163005842	active site
349163005843	YceG-like family; Region: YceG; pfam02618
349163005844	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
349163005845	dimerization interface [polypeptide binding]; other site
349163005846	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
349163005847	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
349163005848	trimer interface [polypeptide binding]; other site
349163005849	active site
349163005850	substrate binding site [chemical binding]; other site
349163005851	CoA binding site [chemical binding]; other site
349163005852	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
349163005853	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
349163005854	metal binding site [ion binding]; metal-binding site
349163005855	dimer interface [polypeptide binding]; other site
349163005856	Predicted methyltransferases [General function prediction only]; Region: COG0313
349163005857	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
349163005858	putative SAM binding site [chemical binding]; other site
349163005859	putative homodimer interface [polypeptide binding]; other site
349163005860	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349163005861	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
349163005862	putative ligand binding site [chemical binding]; other site
349163005863	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
349163005864	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349163005865	dimer interface [polypeptide binding]; other site
349163005866	phosphorylation site [posttranslational modification]
349163005867	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163005868	ATP binding site [chemical binding]; other site
349163005869	Mg2+ binding site [ion binding]; other site
349163005870	G-X-G motif; other site
349163005871	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
349163005872	Cation efflux family; Region: Cation_efflux; pfam01545
349163005873	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
349163005874	classical (c) SDRs; Region: SDR_c; cd05233
349163005875	NAD(P) binding site [chemical binding]; other site
349163005876	active site
349163005877	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
349163005878	quinolinate synthetase; Provisional; Region: PRK09375
349163005879	L-aspartate oxidase; Provisional; Region: PRK06175
349163005880	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
349163005881	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
349163005882	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
349163005883	dimerization interface [polypeptide binding]; other site
349163005884	active site
349163005885	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
349163005886	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
349163005887	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
349163005888	putative MPT binding site; other site
349163005889	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349163005890	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349163005891	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
349163005892	active site
349163005893	8-oxo-dGMP binding site [chemical binding]; other site
349163005894	nudix motif; other site
349163005895	metal binding site [ion binding]; metal-binding site
349163005896	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
349163005897	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
349163005898	putative catalytic cysteine [active]
349163005899	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
349163005900	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
349163005901	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163005902	heme pocket [chemical binding]; other site
349163005903	putative active site [active]
349163005904	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163005905	putative active site [active]
349163005906	heme pocket [chemical binding]; other site
349163005907	PAS domain S-box; Region: sensory_box; TIGR00229
349163005908	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163005909	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163005910	metal binding site [ion binding]; metal-binding site
349163005911	active site
349163005912	I-site; other site
349163005913	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163005914	PAS fold; Region: PAS_4; pfam08448
349163005915	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163005916	putative active site [active]
349163005917	heme pocket [chemical binding]; other site
349163005918	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163005919	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163005920	metal binding site [ion binding]; metal-binding site
349163005921	active site
349163005922	I-site; other site
349163005923	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349163005924	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349163005925	active site
349163005926	Transcriptional regulators [Transcription]; Region: GntR; COG1802
349163005927	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349163005928	DNA-binding site [nucleotide binding]; DNA binding site
349163005929	FCD domain; Region: FCD; pfam07729
349163005930	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
349163005931	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
349163005932	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
349163005933	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
349163005934	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
349163005935	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163005936	FeS/SAM binding site; other site
349163005937	HemN C-terminal domain; Region: HemN_C; pfam06969
349163005938	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
349163005939	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349163005940	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349163005941	DinB family; Region: DinB; cl17821
349163005942	Cytochrome c [Energy production and conversion]; Region: COG3258
349163005943	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
349163005944	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
349163005945	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
349163005946	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163005947	C factor cell-cell signaling protein; Provisional; Region: PRK09009
349163005948	NAD(P) binding site [chemical binding]; other site
349163005949	active site
349163005950	Cytochrome c; Region: Cytochrom_C; pfam00034
349163005951	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
349163005952	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
349163005953	Trp docking motif [polypeptide binding]; other site
349163005954	active site
349163005955	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
349163005956	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
349163005957	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349163005958	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349163005959	active site
349163005960	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
349163005961	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349163005962	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
349163005963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163005964	NAD(P) binding site [chemical binding]; other site
349163005965	active site
349163005966	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
349163005967	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
349163005968	dimer interface [polypeptide binding]; other site
349163005969	active site
349163005970	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
349163005971	putative active site [active]
349163005972	putative catalytic site [active]
349163005973	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349163005974	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349163005975	active site
349163005976	catalytic tetrad [active]
349163005977	HerA helicase [Replication, recombination, and repair]; Region: COG0433
349163005978	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
349163005979	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
349163005980	ligand binding site [chemical binding]; other site
349163005981	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
349163005982	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
349163005983	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
349163005984	[4Fe-4S] binding site [ion binding]; other site
349163005985	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349163005986	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349163005987	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349163005988	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
349163005989	molybdopterin cofactor binding site; other site
349163005990	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
349163005991	4Fe-4S binding domain; Region: Fer4; cl02805
349163005992	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
349163005993	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
349163005994	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
349163005995	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
349163005996	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
349163005997	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
349163005998	substrate binding site [chemical binding]; other site
349163005999	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163006000	PAS domain; Region: PAS_9; pfam13426
349163006001	putative active site [active]
349163006002	heme pocket [chemical binding]; other site
349163006003	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163006004	PAS domain; Region: PAS_9; pfam13426
349163006005	putative active site [active]
349163006006	heme pocket [chemical binding]; other site
349163006007	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349163006008	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349163006009	dimer interface [polypeptide binding]; other site
349163006010	putative CheW interface [polypeptide binding]; other site
349163006011	Transcriptional regulators [Transcription]; Region: PurR; COG1609
349163006012	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349163006013	DNA binding site [nucleotide binding]
349163006014	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
349163006015	putative dimerization interface [polypeptide binding]; other site
349163006016	putative ligand binding site [chemical binding]; other site
349163006017	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
349163006018	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
349163006019	putative NAD(P) binding site [chemical binding]; other site
349163006020	catalytic Zn binding site [ion binding]; other site
349163006021	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
349163006022	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163006023	NAD(P) binding site [chemical binding]; other site
349163006024	active site
349163006025	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
349163006026	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
349163006027	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349163006028	Walker A/P-loop; other site
349163006029	ATP binding site [chemical binding]; other site
349163006030	Q-loop/lid; other site
349163006031	ABC transporter signature motif; other site
349163006032	Walker B; other site
349163006033	D-loop; other site
349163006034	H-loop/switch region; other site
349163006035	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349163006036	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163006037	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163006038	TM-ABC transporter signature motif; other site
349163006039	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315
349163006040	putative ligand binding site [chemical binding]; other site
349163006041	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163006042	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
349163006043	phosphate:H+ symporter; Region: 2A0109; TIGR00887
349163006044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163006045	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
349163006046	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
349163006047	active site
349163006048	metal binding site [ion binding]; metal-binding site
349163006049	hexamer interface [polypeptide binding]; other site
349163006050	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163006051	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163006052	Walker A/P-loop; other site
349163006053	ATP binding site [chemical binding]; other site
349163006054	Q-loop/lid; other site
349163006055	ABC transporter signature motif; other site
349163006056	Walker B; other site
349163006057	D-loop; other site
349163006058	H-loop/switch region; other site
349163006059	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
349163006060	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163006061	ligand binding site [chemical binding]; other site
349163006062	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163006063	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163006064	TM-ABC transporter signature motif; other site
349163006065	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163006066	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163006067	metal binding site [ion binding]; metal-binding site
349163006068	active site
349163006069	I-site; other site
349163006070	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
349163006071	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163006072	FeS/SAM binding site; other site
349163006073	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
349163006074	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
349163006075	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
349163006076	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
349163006077	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
349163006078	ATP-grasp domain; Region: ATP-grasp; pfam02222
349163006079	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
349163006080	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
349163006081	active site
349163006082	DNA binding site [nucleotide binding]
349163006083	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
349163006084	DNA binding site [nucleotide binding]
349163006085	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
349163006086	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349163006087	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
349163006088	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349163006089	ATP binding site [chemical binding]; other site
349163006090	putative Mg++ binding site [ion binding]; other site
349163006091	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349163006092	nucleotide binding region [chemical binding]; other site
349163006093	ATP-binding site [chemical binding]; other site
349163006094	DEAD/H associated; Region: DEAD_assoc; pfam08494
349163006095	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
349163006096	active site
349163006097	metal binding site [ion binding]; metal-binding site
349163006098	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
349163006099	DNA photolyase; Region: DNA_photolyase; pfam00875
349163006100	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
349163006101	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349163006102	hydroxyglutarate oxidase; Provisional; Region: PRK11728
349163006103	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
349163006104	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
349163006105	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163006106	S-adenosylmethionine binding site [chemical binding]; other site
349163006107	MFS/sugar transport protein; Region: MFS_2; pfam13347
349163006108	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
349163006109	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
349163006110	active site
349163006111	metal binding site [ion binding]; metal-binding site
349163006112	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
349163006113	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349163006114	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349163006115	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349163006116	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
349163006117	E3 interaction surface; other site
349163006118	lipoyl attachment site [posttranslational modification]; other site
349163006119	e3 binding domain; Region: E3_binding; pfam02817
349163006120	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
349163006121	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
349163006122	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
349163006123	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
349163006124	TPP-binding site [chemical binding]; other site
349163006125	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
349163006126	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
349163006127	CoA binding domain; Region: CoA_binding; smart00881
349163006128	CoA-ligase; Region: Ligase_CoA; pfam00549
349163006129	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
349163006130	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
349163006131	CoA-ligase; Region: Ligase_CoA; pfam00549
349163006132	Predicted ATPase [General function prediction only]; Region: COG1485
349163006133	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
349163006134	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
349163006135	aspartate aminotransferase; Provisional; Region: PRK05764
349163006136	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349163006137	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163006138	homodimer interface [polypeptide binding]; other site
349163006139	catalytic residue [active]
349163006140	FOG: CBS domain [General function prediction only]; Region: COG0517
349163006141	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
349163006142	BON domain; Region: BON; pfam04972
349163006143	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349163006144	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
349163006145	ligand binding site [chemical binding]; other site
349163006146	flexible hinge region; other site
349163006147	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
349163006148	putative switch regulator; other site
349163006149	non-specific DNA interactions [nucleotide binding]; other site
349163006150	DNA binding site [nucleotide binding]
349163006151	sequence specific DNA binding site [nucleotide binding]; other site
349163006152	putative cAMP binding site [chemical binding]; other site
349163006153	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
349163006154	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
349163006155	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
349163006156	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
349163006157	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
349163006158	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163006159	Walker A/P-loop; other site
349163006160	ATP binding site [chemical binding]; other site
349163006161	Q-loop/lid; other site
349163006162	ABC transporter signature motif; other site
349163006163	Walker B; other site
349163006164	D-loop; other site
349163006165	H-loop/switch region; other site
349163006166	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349163006167	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
349163006168	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163006169	Walker A/P-loop; other site
349163006170	ATP binding site [chemical binding]; other site
349163006171	Q-loop/lid; other site
349163006172	ABC transporter signature motif; other site
349163006173	Walker B; other site
349163006174	D-loop; other site
349163006175	H-loop/switch region; other site
349163006176	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
349163006177	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
349163006178	putative ion selectivity filter; other site
349163006179	putative pore gating glutamate residue; other site
349163006180	putative H+/Cl- coupling transport residue; other site
349163006181	OsmC-like protein; Region: OsmC; pfam02566
349163006182	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
349163006183	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
349163006184	short chain dehydrogenase; Provisional; Region: PRK08339
349163006185	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
349163006186	putative NAD(P) binding site [chemical binding]; other site
349163006187	putative active site [active]
349163006188	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
349163006189	CoA-transferase family III; Region: CoA_transf_3; pfam02515
349163006190	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
349163006191	chaperone protein DnaJ; Provisional; Region: PRK10767
349163006192	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349163006193	HSP70 interaction site [polypeptide binding]; other site
349163006194	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
349163006195	Zn binding sites [ion binding]; other site
349163006196	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
349163006197	dimer interface [polypeptide binding]; other site
349163006198	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
349163006199	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
349163006200	nucleotide binding site [chemical binding]; other site
349163006201	NEF interaction site [polypeptide binding]; other site
349163006202	SBD interface [polypeptide binding]; other site
349163006203	GrpE; Region: GrpE; pfam01025
349163006204	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
349163006205	dimer interface [polypeptide binding]; other site
349163006206	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
349163006207	short chain dehydrogenase; Provisional; Region: PRK09134
349163006208	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163006209	NAD(P) binding site [chemical binding]; other site
349163006210	active site
349163006211	Methyltransferase domain; Region: Methyltransf_24; pfam13578
349163006212	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
349163006213	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
349163006214	putative active site [active]
349163006215	putative substrate binding site [chemical binding]; other site
349163006216	ATP binding site [chemical binding]; other site
349163006217	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
349163006218	RNA/DNA hybrid binding site [nucleotide binding]; other site
349163006219	active site
349163006220	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163006221	short chain dehydrogenase; Provisional; Region: PRK07060
349163006222	NAD(P) binding site [chemical binding]; other site
349163006223	active site
349163006224	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
349163006225	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
349163006226	Walker A/P-loop; other site
349163006227	ATP binding site [chemical binding]; other site
349163006228	Q-loop/lid; other site
349163006229	ABC transporter signature motif; other site
349163006230	Walker B; other site
349163006231	D-loop; other site
349163006232	H-loop/switch region; other site
349163006233	TOBE domain; Region: TOBE_2; pfam08402
349163006234	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
349163006235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163006236	dimer interface [polypeptide binding]; other site
349163006237	conserved gate region; other site
349163006238	putative PBP binding loops; other site
349163006239	ABC-ATPase subunit interface; other site
349163006240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163006241	dimer interface [polypeptide binding]; other site
349163006242	conserved gate region; other site
349163006243	putative PBP binding loops; other site
349163006244	ABC-ATPase subunit interface; other site
349163006245	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349163006246	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349163006247	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
349163006248	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
349163006249	NAD(P) binding site [chemical binding]; other site
349163006250	L-fuculokinase; Region: fuculo_kin_coli; TIGR02628
349163006251	uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779
349163006252	putative N- and C-terminal domain interface [polypeptide binding]; other site
349163006253	putative active site [active]
349163006254	MgATP binding site [chemical binding]; other site
349163006255	catalytic site [active]
349163006256	metal binding site [ion binding]; metal-binding site
349163006257	putative carbohydrate binding site [chemical binding]; other site
349163006258	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
349163006259	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
349163006260	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
349163006261	putative active site [active]
349163006262	putative catalytic site [active]
349163006263	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
349163006264	Uncharacterized protein conserved in archaea (DUF2111); Region: DUF2111; cl01667
349163006265	ribonuclease PH; Reviewed; Region: rph; PRK00173
349163006266	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
349163006267	oligomer interface [polypeptide binding]; other site
349163006268	RNA binding site [nucleotide binding]; other site
349163006269	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
349163006270	active site
349163006271	dimerization interface [polypeptide binding]; other site
349163006272	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
349163006273	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
349163006274	active site
349163006275	dimer interface [polypeptide binding]; other site
349163006276	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
349163006277	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
349163006278	active site
349163006279	FMN binding site [chemical binding]; other site
349163006280	substrate binding site [chemical binding]; other site
349163006281	3Fe-4S cluster binding site [ion binding]; other site
349163006282	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
349163006283	domain interface; other site
349163006284	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
349163006285	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349163006286	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349163006287	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349163006288	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
349163006289	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
349163006290	putative NAD(P) binding site [chemical binding]; other site
349163006291	active site
349163006292	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
349163006293	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
349163006294	catalytic site [active]
349163006295	putative active site [active]
349163006296	putative substrate binding site [chemical binding]; other site
349163006297	KpsF/GutQ family protein; Region: kpsF; TIGR00393
349163006298	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
349163006299	putative active site [active]
349163006300	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
349163006301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
349163006302	OstA-like protein; Region: OstA; cl00844
349163006303	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
349163006304	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
349163006305	Walker A/P-loop; other site
349163006306	ATP binding site [chemical binding]; other site
349163006307	Q-loop/lid; other site
349163006308	ABC transporter signature motif; other site
349163006309	Walker B; other site
349163006310	D-loop; other site
349163006311	H-loop/switch region; other site
349163006312	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
349163006313	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
349163006314	5S rRNA interface [nucleotide binding]; other site
349163006315	CTC domain interface [polypeptide binding]; other site
349163006316	L16 interface [polypeptide binding]; other site
349163006317	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
349163006318	putative active site [active]
349163006319	catalytic residue [active]
349163006320	GTP-binding protein YchF; Reviewed; Region: PRK09601
349163006321	YchF GTPase; Region: YchF; cd01900
349163006322	G1 box; other site
349163006323	GTP/Mg2+ binding site [chemical binding]; other site
349163006324	Switch I region; other site
349163006325	G2 box; other site
349163006326	Switch II region; other site
349163006327	G3 box; other site
349163006328	G4 box; other site
349163006329	G5 box; other site
349163006330	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
349163006331	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
349163006332	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349163006333	ATP binding site [chemical binding]; other site
349163006334	putative Mg++ binding site [ion binding]; other site
349163006335	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
349163006336	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
349163006337	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
349163006338	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
349163006339	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
349163006340	beta subunit interaction interface [polypeptide binding]; other site
349163006341	Walker A motif; other site
349163006342	ATP binding site [chemical binding]; other site
349163006343	Walker B motif; other site
349163006344	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
349163006345	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
349163006346	core domain interface [polypeptide binding]; other site
349163006347	delta subunit interface [polypeptide binding]; other site
349163006348	epsilon subunit interface [polypeptide binding]; other site
349163006349	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
349163006350	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
349163006351	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
349163006352	alpha subunit interaction interface [polypeptide binding]; other site
349163006353	Walker A motif; other site
349163006354	ATP binding site [chemical binding]; other site
349163006355	Walker B motif; other site
349163006356	inhibitor binding site; inhibition site
349163006357	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
349163006358	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
349163006359	gamma subunit interface [polypeptide binding]; other site
349163006360	epsilon subunit interface [polypeptide binding]; other site
349163006361	LBP interface [polypeptide binding]; other site
349163006362	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
349163006363	benzoate transport; Region: 2A0115; TIGR00895
349163006364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163006365	putative substrate translocation pore; other site
349163006366	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
349163006367	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
349163006368	Active site cavity [active]
349163006369	catalytic acid [active]
349163006370	peptide chain release factor 2; Provisional; Region: PRK07342
349163006371	This domain is found in peptide chain release factors; Region: PCRF; smart00937
349163006372	RF-1 domain; Region: RF-1; pfam00472
349163006373	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
349163006374	Transglycosylase; Region: Transgly; pfam00912
349163006375	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
349163006376	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
349163006377	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
349163006378	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
349163006379	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
349163006380	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
349163006381	DctM-like transporters; Region: DctM; pfam06808
349163006382	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
349163006383	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
349163006384	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163006385	NAD(P) binding site [chemical binding]; other site
349163006386	active site
349163006387	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
349163006388	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163006389	FeS/SAM binding site; other site
349163006390	HemN C-terminal domain; Region: HemN_C; pfam06969
349163006391	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
349163006392	rRNA interaction site [nucleotide binding]; other site
349163006393	S8 interaction site; other site
349163006394	putative laminin-1 binding site; other site
349163006395	elongation factor Ts; Provisional; Region: tsf; PRK09377
349163006396	UBA/TS-N domain; Region: UBA; pfam00627
349163006397	Elongation factor TS; Region: EF_TS; pfam00889
349163006398	Elongation factor TS; Region: EF_TS; pfam00889
349163006399	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163006400	PAS domain; Region: PAS_9; pfam13426
349163006401	putative active site [active]
349163006402	heme pocket [chemical binding]; other site
349163006403	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163006404	PAS domain; Region: PAS_9; pfam13426
349163006405	putative active site [active]
349163006406	heme pocket [chemical binding]; other site
349163006407	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349163006408	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349163006409	dimer interface [polypeptide binding]; other site
349163006410	putative CheW interface [polypeptide binding]; other site
349163006411	Uncharacterized conserved protein [Function unknown]; Region: COG3791
349163006412	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
349163006413	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
349163006414	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
349163006415	substrate binding pocket [chemical binding]; other site
349163006416	dimer interface [polypeptide binding]; other site
349163006417	inhibitor binding site; inhibition site
349163006418	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
349163006419	B12 binding site [chemical binding]; other site
349163006420	cobalt ligand [ion binding]; other site
349163006421	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
349163006422	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
349163006423	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
349163006424	elongation factor P; Validated; Region: PRK00529
349163006425	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
349163006426	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
349163006427	RNA binding site [nucleotide binding]; other site
349163006428	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
349163006429	RNA binding site [nucleotide binding]; other site
349163006430	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
349163006431	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
349163006432	active site
349163006433	dimerization interface [polypeptide binding]; other site
349163006434	OmpA family; Region: OmpA; pfam00691
349163006435	hypothetical protein; Validated; Region: PRK09039
349163006436	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349163006437	ligand binding site [chemical binding]; other site
349163006438	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
349163006439	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
349163006440	metal ion-dependent adhesion site (MIDAS); other site
349163006441	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
349163006442	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
349163006443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
349163006444	Walker A motif; other site
349163006445	ATP binding site [chemical binding]; other site
349163006446	Walker B motif; other site
349163006447	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349163006448	HSP70 interaction site [polypeptide binding]; other site
349163006449	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
349163006450	enoyl-CoA hydratase; Provisional; Region: PRK08140
349163006451	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349163006452	substrate binding site [chemical binding]; other site
349163006453	oxyanion hole (OAH) forming residues; other site
349163006454	trimer interface [polypeptide binding]; other site
349163006455	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
349163006456	catalytic nucleophile [active]
349163006457	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
349163006458	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
349163006459	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
349163006460	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
349163006461	GTP binding site; other site
349163006462	MarC family integral membrane protein; Region: MarC; pfam01914
349163006463	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349163006464	IHF dimer interface [polypeptide binding]; other site
349163006465	IHF - DNA interface [nucleotide binding]; other site
349163006466	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
349163006467	active site
349163006468	dimer interface [polypeptide binding]; other site
349163006469	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
349163006470	active site
349163006471	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
349163006472	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
349163006473	DNA binding site [nucleotide binding]
349163006474	catalytic residue [active]
349163006475	H2TH interface [polypeptide binding]; other site
349163006476	putative catalytic residues [active]
349163006477	turnover-facilitating residue; other site
349163006478	intercalation triad [nucleotide binding]; other site
349163006479	8OG recognition residue [nucleotide binding]; other site
349163006480	putative reading head residues; other site
349163006481	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
349163006482	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
349163006483	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
349163006484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163006485	S-adenosylmethionine binding site [chemical binding]; other site
349163006486	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
349163006487	Flavoprotein; Region: Flavoprotein; pfam02441
349163006488	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
349163006489	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
349163006490	trimer interface [polypeptide binding]; other site
349163006491	active site
349163006492	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163006493	NAD(P) binding site [chemical binding]; other site
349163006494	active site
349163006495	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
349163006496	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
349163006497	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
349163006498	catalytic core [active]
349163006499	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
349163006500	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
349163006501	dimer interface [polypeptide binding]; other site
349163006502	active site
349163006503	citrylCoA binding site [chemical binding]; other site
349163006504	NADH binding [chemical binding]; other site
349163006505	cationic pore residues; other site
349163006506	oxalacetate/citrate binding site [chemical binding]; other site
349163006507	coenzyme A binding site [chemical binding]; other site
349163006508	catalytic triad [active]
349163006509	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349163006510	dimerization interface [polypeptide binding]; other site
349163006511	putative DNA binding site [nucleotide binding]; other site
349163006512	putative Zn2+ binding site [ion binding]; other site
349163006513	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
349163006514	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
349163006515	FMN binding site [chemical binding]; other site
349163006516	active site
349163006517	substrate binding site [chemical binding]; other site
349163006518	catalytic residue [active]
349163006519	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
349163006520	classical (c) SDRs; Region: SDR_c; cd05233
349163006521	NAD(P) binding site [chemical binding]; other site
349163006522	active site
349163006523	PA14 domain; Region: PA14; cl08459
349163006524	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
349163006525	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349163006526	DNA binding residues [nucleotide binding]
349163006527	dimerization interface [polypeptide binding]; other site
349163006528	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
349163006529	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
349163006530	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
349163006531	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
349163006532	dimer interface [polypeptide binding]; other site
349163006533	Trp docking motif [polypeptide binding]; other site
349163006534	active site
349163006535	Protein of unknown function (DUF779); Region: DUF779; pfam05610
349163006536	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
349163006537	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
349163006538	NAD(P) binding site [chemical binding]; other site
349163006539	catalytic residues [active]
349163006540	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
349163006541	GAF domain; Region: GAF; pfam01590
349163006542	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163006543	Walker A motif; other site
349163006544	ATP binding site [chemical binding]; other site
349163006545	Walker B motif; other site
349163006546	arginine finger; other site
349163006547	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349163006548	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
349163006549	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
349163006550	active site
349163006551	imidazolonepropionase; Validated; Region: PRK09356
349163006552	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
349163006553	active site
349163006554	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
349163006555	active sites [active]
349163006556	tetramer interface [polypeptide binding]; other site
349163006557	N-formylglutamate amidohydrolase; Region: FGase; cl01522
349163006558	urocanate hydratase; Provisional; Region: PRK05414
349163006559	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
349163006560	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349163006561	DNA-binding site [nucleotide binding]; DNA binding site
349163006562	UTRA domain; Region: UTRA; pfam07702
349163006563	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
349163006564	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
349163006565	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
349163006566	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
349163006567	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
349163006568	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349163006569	ATP binding site [chemical binding]; other site
349163006570	putative Mg++ binding site [ion binding]; other site
349163006571	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349163006572	nucleotide binding region [chemical binding]; other site
349163006573	ATP-binding site [chemical binding]; other site
349163006574	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
349163006575	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
349163006576	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
349163006577	generic binding surface II; other site
349163006578	ssDNA binding site; other site
349163006579	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349163006580	ATP binding site [chemical binding]; other site
349163006581	putative Mg++ binding site [ion binding]; other site
349163006582	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349163006583	nucleotide binding region [chemical binding]; other site
349163006584	ATP-binding site [chemical binding]; other site
349163006585	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
349163006586	nudix motif; other site
349163006587	TMAO/DMSO reductase; Reviewed; Region: PRK05363
349163006588	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
349163006589	Moco binding site; other site
349163006590	metal coordination site [ion binding]; other site
349163006591	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
349163006592	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
349163006593	homodimer interface [polypeptide binding]; other site
349163006594	metal binding site [ion binding]; metal-binding site
349163006595	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
349163006596	homodimer interface [polypeptide binding]; other site
349163006597	active site
349163006598	putative chemical substrate binding site [chemical binding]; other site
349163006599	metal binding site [ion binding]; metal-binding site
349163006600	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
349163006601	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
349163006602	active site
349163006603	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
349163006604	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
349163006605	HflX GTPase family; Region: HflX; cd01878
349163006606	G1 box; other site
349163006607	GTP/Mg2+ binding site [chemical binding]; other site
349163006608	Switch I region; other site
349163006609	G2 box; other site
349163006610	G3 box; other site
349163006611	Switch II region; other site
349163006612	G4 box; other site
349163006613	G5 box; other site
349163006614	bacterial Hfq-like; Region: Hfq; cd01716
349163006615	hexamer interface [polypeptide binding]; other site
349163006616	Sm1 motif; other site
349163006617	RNA binding site [nucleotide binding]; other site
349163006618	Sm2 motif; other site
349163006619	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
349163006620	protein-splicing catalytic site; other site
349163006621	thioester formation/cholesterol transfer; other site
349163006622	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
349163006623	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
349163006624	Ligand Binding Site [chemical binding]; other site
349163006625	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
349163006626	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163006627	catalytic loop [active]
349163006628	iron binding site [ion binding]; other site
349163006629	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349163006630	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349163006631	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349163006632	catalytic residue [active]
349163006633	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
349163006634	serine O-acetyltransferase; Region: cysE; TIGR01172
349163006635	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
349163006636	trimer interface [polypeptide binding]; other site
349163006637	active site
349163006638	substrate binding site [chemical binding]; other site
349163006639	CoA binding site [chemical binding]; other site
349163006640	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
349163006641	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349163006642	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
349163006643	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
349163006644	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
349163006645	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
349163006646	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
349163006647	CPxP  motif; other site
349163006648	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
349163006649	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
349163006650	Glycoprotease family; Region: Peptidase_M22; pfam00814
349163006651	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
349163006652	putative FMN binding site [chemical binding]; other site
349163006653	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
349163006654	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
349163006655	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
349163006656	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349163006657	Methyltransferase domain; Region: Methyltransf_11; pfam08241
349163006658	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
349163006659	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
349163006660	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349163006661	acyl-activating enzyme (AAE) consensus motif; other site
349163006662	AMP binding site [chemical binding]; other site
349163006663	active site
349163006664	CoA binding site [chemical binding]; other site
349163006665	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
349163006666	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
349163006667	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
349163006668	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
349163006669	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349163006670	active site
349163006671	HIGH motif; other site
349163006672	nucleotide binding site [chemical binding]; other site
349163006673	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
349163006674	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
349163006675	active site
349163006676	KMSKS motif; other site
349163006677	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
349163006678	tRNA binding surface [nucleotide binding]; other site
349163006679	anticodon binding site; other site
349163006680	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
349163006681	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
349163006682	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
349163006683	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
349163006684	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
349163006685	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
349163006686	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
349163006687	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
349163006688	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
349163006689	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163006690	catalytic residue [active]
349163006691	preprotein translocase subunit SecB; Validated; Region: PRK05751
349163006692	SecA binding site; other site
349163006693	Preprotein binding site; other site
349163006694	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
349163006695	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
349163006696	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
349163006697	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
349163006698	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
349163006699	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
349163006700	tetrameric interface [polypeptide binding]; other site
349163006701	NAD binding site [chemical binding]; other site
349163006702	catalytic residues [active]
349163006703	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163006704	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163006705	LysR substrate binding domain; Region: LysR_substrate; pfam03466
349163006706	dimerization interface [polypeptide binding]; other site
349163006707	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
349163006708	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349163006709	HlyD family secretion protein; Region: HlyD_3; pfam13437
349163006710	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
349163006711	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
349163006712	Walker A/P-loop; other site
349163006713	ATP binding site [chemical binding]; other site
349163006714	Q-loop/lid; other site
349163006715	ABC transporter signature motif; other site
349163006716	Walker B; other site
349163006717	D-loop; other site
349163006718	H-loop/switch region; other site
349163006719	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
349163006720	Walker A/P-loop; other site
349163006721	ATP binding site [chemical binding]; other site
349163006722	Q-loop/lid; other site
349163006723	ABC transporter signature motif; other site
349163006724	Walker B; other site
349163006725	D-loop; other site
349163006726	H-loop/switch region; other site
349163006727	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
349163006728	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
349163006729	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
349163006730	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
349163006731	hybrid cluster protein; Provisional; Region: PRK05290
349163006732	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349163006733	ACS interaction site; other site
349163006734	CODH interaction site; other site
349163006735	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349163006736	ACS interaction site; other site
349163006737	CODH interaction site; other site
349163006738	metal cluster binding site [ion binding]; other site
349163006739	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
349163006740	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163006741	catalytic loop [active]
349163006742	iron binding site [ion binding]; other site
349163006743	Methane monooxygenase (MMO) reductase of methanotrophs catalyzes the NADH-dependent hydroxylation of methane to methanol. This multicomponent enzyme mediates electron transfer via a hydroxylase (MMOH), a coupling protein, and a reductase which is...; Region: MMO_FAD_NAD_binding; cd06210
349163006744	FAD binding pocket [chemical binding]; other site
349163006745	FAD binding motif [chemical binding]; other site
349163006746	phosphate binding motif [ion binding]; other site
349163006747	beta-alpha-beta structure motif; other site
349163006748	NAD binding pocket [chemical binding]; other site
349163006749	Transcriptional regulator; Region: Rrf2; cl17282
349163006750	Rrf2 family protein; Region: rrf2_super; TIGR00738
349163006751	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
349163006752	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
349163006753	Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935
349163006754	putative active site [active]
349163006755	putative catalytic site [active]
349163006756	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163006757	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
349163006758	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
349163006759	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
349163006760	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349163006761	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163006762	CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI; Region: cas1_ECOLI; TIGR03638
349163006763	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
349163006764	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
349163006765	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
349163006766	CT1975-like protein; Region: Cas_CT1975; pfam09344
349163006767	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
349163006768	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
349163006769	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
349163006770	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
349163006771	Integrase core domain; Region: rve; pfam00665
349163006772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163006773	ATP binding site [chemical binding]; other site
349163006774	Walker B motif; other site
349163006775	arginine finger; other site
349163006776	Peptidase family M41; Region: Peptidase_M41; pfam01434
349163006777	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163006778	non-specific DNA binding site [nucleotide binding]; other site
349163006779	salt bridge; other site
349163006780	sequence-specific DNA binding site [nucleotide binding]; other site
349163006781	NIPSNAP; Region: NIPSNAP; pfam07978
349163006782	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349163006783	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
349163006784	catalytic residues [active]
349163006785	catalytic nucleophile [active]
349163006786	Recombinase; Region: Recombinase; pfam07508
349163006787	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
349163006788	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
349163006789	Clp amino terminal domain; Region: Clp_N; pfam02861
349163006790	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163006791	Walker A motif; other site
349163006792	ATP binding site [chemical binding]; other site
349163006793	Walker B motif; other site
349163006794	arginine finger; other site
349163006795	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163006796	Walker A motif; other site
349163006797	ATP binding site [chemical binding]; other site
349163006798	Walker B motif; other site
349163006799	arginine finger; other site
349163006800	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
349163006801	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
349163006802	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
349163006803	MOSC domain; Region: MOSC; pfam03473
349163006804	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
349163006805	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
349163006806	Walker A motif; other site
349163006807	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
349163006808	MoaE interaction surface [polypeptide binding]; other site
349163006809	MoeB interaction surface [polypeptide binding]; other site
349163006810	thiocarboxylated glycine; other site
349163006811	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
349163006812	MoaD interaction [polypeptide binding]; other site
349163006813	active site residues [active]
349163006814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163006815	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349163006816	active site
349163006817	phosphorylation site [posttranslational modification]
349163006818	dimerization interface [polypeptide binding]; other site
349163006819	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163006820	DNA binding site [nucleotide binding]
349163006821	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
349163006822	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163006823	FeS/SAM binding site; other site
349163006824	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
349163006825	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
349163006826	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
349163006827	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
349163006828	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
349163006829	TPP-binding site; other site
349163006830	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
349163006831	PYR/PP interface [polypeptide binding]; other site
349163006832	dimer interface [polypeptide binding]; other site
349163006833	TPP binding site [chemical binding]; other site
349163006834	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
349163006835	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
349163006836	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
349163006837	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
349163006838	ligand binding site; other site
349163006839	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
349163006840	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
349163006841	B12 binding site [chemical binding]; other site
349163006842	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163006843	FeS/SAM binding site; other site
349163006844	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
349163006845	putative active site [active]
349163006846	YdjC motif; other site
349163006847	Mg binding site [ion binding]; other site
349163006848	putative homodimer interface [polypeptide binding]; other site
349163006849	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
349163006850	Ferredoxin [Energy production and conversion]; Region: COG1146
349163006851	4Fe-4S binding domain; Region: Fer4; cl02805
349163006852	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
349163006853	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
349163006854	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
349163006855	Hemerythrin-like domain; Region: Hr-like; cd12108
349163006856	Fe binding site [ion binding]; other site
349163006857	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
349163006858	apolar tunnel; other site
349163006859	heme binding site [chemical binding]; other site
349163006860	dimerization interface [polypeptide binding]; other site
349163006861	Transcriptional regulator; Region: Rrf2; cl17282
349163006862	Rrf2 family protein; Region: rrf2_super; TIGR00738
349163006863	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
349163006864	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
349163006865	ATP binding site [chemical binding]; other site
349163006866	putative Mg++ binding site [ion binding]; other site
349163006867	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349163006868	nucleotide binding region [chemical binding]; other site
349163006869	ATP-binding site [chemical binding]; other site
349163006870	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
349163006871	RNA binding site [nucleotide binding]; other site
349163006872	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
349163006873	Coenzyme A transferase; Region: CoA_trans; cl17247
349163006874	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
349163006875	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
349163006876	dimer interface [polypeptide binding]; other site
349163006877	active site
349163006878	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
349163006879	active site
349163006880	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
349163006881	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
349163006882	active site
349163006883	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
349163006884	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349163006885	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
349163006886	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
349163006887	dimer interface [polypeptide binding]; other site
349163006888	active site
349163006889	heme binding site [chemical binding]; other site
349163006890	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
349163006891	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163006892	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163006893	TM-ABC transporter signature motif; other site
349163006894	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
349163006895	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163006896	putative ligand binding site [chemical binding]; other site
349163006897	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163006898	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163006899	Walker A/P-loop; other site
349163006900	ATP binding site [chemical binding]; other site
349163006901	Q-loop/lid; other site
349163006902	ABC transporter signature motif; other site
349163006903	Walker B; other site
349163006904	D-loop; other site
349163006905	H-loop/switch region; other site
349163006906	short chain dehydrogenase; Provisional; Region: PRK08628
349163006907	classical (c) SDRs; Region: SDR_c; cd05233
349163006908	NAD(P) binding site [chemical binding]; other site
349163006909	active site
349163006910	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
349163006911	Amidohydrolase; Region: Amidohydro_2; pfam04909
349163006912	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349163006913	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
349163006914	substrate binding site [chemical binding]; other site
349163006915	ATP binding site [chemical binding]; other site
349163006916	mannonate dehydratase; Provisional; Region: PRK03906
349163006917	mannonate dehydratase; Region: uxuA; TIGR00695
349163006918	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
349163006919	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
349163006920	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
349163006921	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163006922	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
349163006923	NAD(P) binding site [chemical binding]; other site
349163006924	active site
349163006925	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349163006926	Transcriptional regulators [Transcription]; Region: GntR; COG1802
349163006927	DNA-binding site [nucleotide binding]; DNA binding site
349163006928	FCD domain; Region: FCD; pfam07729
349163006929	galactarate dehydratase; Region: galactar-dH20; TIGR03248
349163006930	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
349163006931	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
349163006932	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
349163006933	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
349163006934	Walker A/P-loop; other site
349163006935	ATP binding site [chemical binding]; other site
349163006936	Q-loop/lid; other site
349163006937	ABC transporter signature motif; other site
349163006938	Walker B; other site
349163006939	D-loop; other site
349163006940	H-loop/switch region; other site
349163006941	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
349163006942	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
349163006943	TM-ABC transporter signature motif; other site
349163006944	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163006945	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
349163006946	Walker A/P-loop; other site
349163006947	ATP binding site [chemical binding]; other site
349163006948	Q-loop/lid; other site
349163006949	ABC transporter signature motif; other site
349163006950	Walker B; other site
349163006951	D-loop; other site
349163006952	H-loop/switch region; other site
349163006953	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
349163006954	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163006955	TM-ABC transporter signature motif; other site
349163006956	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349163006957	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
349163006958	ligand binding site [chemical binding]; other site
349163006959	AAA domain; Region: AAA_26; pfam13500
349163006960	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
349163006961	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
349163006962	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
349163006963	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349163006964	catalytic residue [active]
349163006965	biotin synthase; Region: bioB; TIGR00433
349163006966	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163006967	FeS/SAM binding site; other site
349163006968	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
349163006969	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
349163006970	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349163006971	inhibitor-cofactor binding pocket; inhibition site
349163006972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163006973	catalytic residue [active]
349163006974	CCC1-related family of proteins; Region: CCC1_like; cl00278
349163006975	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
349163006976	glutamate--cysteine ligase; Region: PLN02611
349163006977	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
349163006978	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
349163006979	UbiA prenyltransferase family; Region: UbiA; pfam01040
349163006980	Predicted methyltransferase [General function prediction only]; Region: COG3897
349163006981	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
349163006982	Iron-sulfur protein interface; other site
349163006983	proximal quinone binding site [chemical binding]; other site
349163006984	SdhD (CybS) interface [polypeptide binding]; other site
349163006985	proximal heme binding site [chemical binding]; other site
349163006986	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
349163006987	putative SdhC subunit interface [polypeptide binding]; other site
349163006988	putative proximal heme binding site [chemical binding]; other site
349163006989	putative Iron-sulfur protein interface [polypeptide binding]; other site
349163006990	putative proximal quinone binding site; other site
349163006991	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
349163006992	L-aspartate oxidase; Provisional; Region: PRK06175
349163006993	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
349163006994	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
349163006995	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
349163006996	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
349163006997	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
349163006998	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349163006999	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349163007000	dimer interface [polypeptide binding]; other site
349163007001	phosphorylation site [posttranslational modification]
349163007002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163007003	ATP binding site [chemical binding]; other site
349163007004	Mg2+ binding site [ion binding]; other site
349163007005	G-X-G motif; other site
349163007006	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349163007007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163007008	active site
349163007009	phosphorylation site [posttranslational modification]
349163007010	intermolecular recognition site; other site
349163007011	dimerization interface [polypeptide binding]; other site
349163007012	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163007013	DNA binding site [nucleotide binding]
349163007014	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
349163007015	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
349163007016	active site
349163007017	substrate-binding site [chemical binding]; other site
349163007018	metal-binding site [ion binding]
349163007019	ATP binding site [chemical binding]; other site
349163007020	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
349163007021	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
349163007022	metal binding site [ion binding]; metal-binding site
349163007023	putative dimer interface [polypeptide binding]; other site
349163007024	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
349163007025	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
349163007026	MarR family; Region: MarR; pfam01047
349163007027	HlyD family secretion protein; Region: HlyD; pfam00529
349163007028	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349163007029	HlyD family secretion protein; Region: HlyD_3; pfam13437
349163007030	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
349163007031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163007032	putative substrate translocation pore; other site
349163007033	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349163007034	active site
349163007035	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163007036	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
349163007037	putative ADP-binding pocket [chemical binding]; other site
349163007038	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
349163007039	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349163007040	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
349163007041	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
349163007042	Sel1-like repeats; Region: SEL1; smart00671
349163007043	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
349163007044	Sel1-like repeats; Region: SEL1; smart00671
349163007045	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
349163007046	HlyD family secretion protein; Region: HlyD_3; pfam13437
349163007047	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
349163007048	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
349163007049	putative active site [active]
349163007050	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349163007051	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163007052	Walker A/P-loop; other site
349163007053	ATP binding site [chemical binding]; other site
349163007054	Q-loop/lid; other site
349163007055	ABC transporter signature motif; other site
349163007056	Walker B; other site
349163007057	D-loop; other site
349163007058	H-loop/switch region; other site
349163007059	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
349163007060	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349163007061	Coenzyme A binding pocket [chemical binding]; other site
349163007062	flagellar motor protein MotA; Validated; Region: PRK09110
349163007063	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
349163007064	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
349163007065	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349163007066	ligand binding site [chemical binding]; other site
349163007067	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
349163007068	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
349163007069	tetramer interface [polypeptide binding]; other site
349163007070	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163007071	catalytic residue [active]
349163007072	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
349163007073	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
349163007074	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349163007075	active site
349163007076	Predicted membrane protein [Function unknown]; Region: COG2246
349163007077	GtrA-like protein; Region: GtrA; pfam04138
349163007078	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
349163007079	catalytic triad [active]
349163007080	dimer interface [polypeptide binding]; other site
349163007081	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
349163007082	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
349163007083	Moco binding site; other site
349163007084	metal coordination site [ion binding]; other site
349163007085	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
349163007086	SmpB-tmRNA interface; other site
349163007087	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
349163007088	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
349163007089	dimer interface [polypeptide binding]; other site
349163007090	active site
349163007091	catalytic residue [active]
349163007092	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349163007093	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349163007094	catalytic residue [active]
349163007095	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
349163007096	tetramer interfaces [polypeptide binding]; other site
349163007097	binuclear metal-binding site [ion binding]; other site
349163007098	Competence-damaged protein; Region: CinA; pfam02464
349163007099	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163007100	PAS domain; Region: PAS_9; pfam13426
349163007101	putative active site [active]
349163007102	heme pocket [chemical binding]; other site
349163007103	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163007104	Chromate transporter; Region: Chromate_transp; pfam02417
349163007105	Chromate transporter; Region: Chromate_transp; pfam02417
349163007106	PBP superfamily domain; Region: PBP_like_2; cl17296
349163007107	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
349163007108	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163007109	dimer interface [polypeptide binding]; other site
349163007110	conserved gate region; other site
349163007111	putative PBP binding loops; other site
349163007112	ABC-ATPase subunit interface; other site
349163007113	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
349163007114	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163007115	dimer interface [polypeptide binding]; other site
349163007116	conserved gate region; other site
349163007117	putative PBP binding loops; other site
349163007118	ABC-ATPase subunit interface; other site
349163007119	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
349163007120	putative deacylase active site [active]
349163007121	MAPEG family; Region: MAPEG; cl09190
349163007122	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
349163007123	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
349163007124	active site
349163007125	Zn binding site [ion binding]; other site
349163007126	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
349163007127	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
349163007128	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
349163007129	alphaNTD - beta interaction site [polypeptide binding]; other site
349163007130	alphaNTD homodimer interface [polypeptide binding]; other site
349163007131	alphaNTD - beta' interaction site [polypeptide binding]; other site
349163007132	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
349163007133	30S ribosomal protein S11; Validated; Region: PRK05309
349163007134	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
349163007135	30S ribosomal protein S13; Region: bact_S13; TIGR03631
349163007136	adenylate kinase; Reviewed; Region: adk; PRK00279
349163007137	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
349163007138	AMP-binding site [chemical binding]; other site
349163007139	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
349163007140	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
349163007141	SecY translocase; Region: SecY; pfam00344
349163007142	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
349163007143	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
349163007144	23S rRNA binding site [nucleotide binding]; other site
349163007145	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
349163007146	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
349163007147	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
349163007148	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
349163007149	5S rRNA interface [nucleotide binding]; other site
349163007150	23S rRNA interface [nucleotide binding]; other site
349163007151	L5 interface [polypeptide binding]; other site
349163007152	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
349163007153	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
349163007154	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
349163007155	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
349163007156	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
349163007157	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
349163007158	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
349163007159	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
349163007160	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
349163007161	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
349163007162	RNA binding site [nucleotide binding]; other site
349163007163	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
349163007164	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
349163007165	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
349163007166	putative translocon interaction site; other site
349163007167	23S rRNA interface [nucleotide binding]; other site
349163007168	signal recognition particle (SRP54) interaction site; other site
349163007169	L23 interface [polypeptide binding]; other site
349163007170	trigger factor interaction site; other site
349163007171	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
349163007172	23S rRNA interface [nucleotide binding]; other site
349163007173	5S rRNA interface [nucleotide binding]; other site
349163007174	putative antibiotic binding site [chemical binding]; other site
349163007175	L25 interface [polypeptide binding]; other site
349163007176	L27 interface [polypeptide binding]; other site
349163007177	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
349163007178	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
349163007179	G-X-X-G motif; other site
349163007180	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
349163007181	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
349163007182	putative translocon binding site; other site
349163007183	protein-rRNA interface [nucleotide binding]; other site
349163007184	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
349163007185	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
349163007186	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
349163007187	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
349163007188	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
349163007189	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
349163007190	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
349163007191	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
349163007192	elongation factor Tu; Reviewed; Region: PRK00049
349163007193	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
349163007194	G1 box; other site
349163007195	GEF interaction site [polypeptide binding]; other site
349163007196	GTP/Mg2+ binding site [chemical binding]; other site
349163007197	Switch I region; other site
349163007198	G2 box; other site
349163007199	G3 box; other site
349163007200	Switch II region; other site
349163007201	G4 box; other site
349163007202	G5 box; other site
349163007203	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
349163007204	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
349163007205	Antibiotic Binding Site [chemical binding]; other site
349163007206	30S ribosomal protein S7; Validated; Region: PRK05302
349163007207	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
349163007208	S17 interaction site [polypeptide binding]; other site
349163007209	S8 interaction site; other site
349163007210	16S rRNA interaction site [nucleotide binding]; other site
349163007211	streptomycin interaction site [chemical binding]; other site
349163007212	23S rRNA interaction site [nucleotide binding]; other site
349163007213	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
349163007214	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
349163007215	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
349163007216	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
349163007217	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
349163007218	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
349163007219	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
349163007220	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
349163007221	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
349163007222	DNA binding site [nucleotide binding]
349163007223	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
349163007224	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
349163007225	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
349163007226	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
349163007227	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
349163007228	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
349163007229	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
349163007230	RPB3 interaction site [polypeptide binding]; other site
349163007231	RPB1 interaction site [polypeptide binding]; other site
349163007232	RPB11 interaction site [polypeptide binding]; other site
349163007233	RPB10 interaction site [polypeptide binding]; other site
349163007234	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
349163007235	L11 interface [polypeptide binding]; other site
349163007236	putative EF-Tu interaction site [polypeptide binding]; other site
349163007237	putative EF-G interaction site [polypeptide binding]; other site
349163007238	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
349163007239	23S rRNA interface [nucleotide binding]; other site
349163007240	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
349163007241	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
349163007242	mRNA/rRNA interface [nucleotide binding]; other site
349163007243	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
349163007244	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
349163007245	23S rRNA interface [nucleotide binding]; other site
349163007246	L7/L12 interface [polypeptide binding]; other site
349163007247	putative thiostrepton binding site; other site
349163007248	L25 interface [polypeptide binding]; other site
349163007249	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
349163007250	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349163007251	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349163007252	active site
349163007253	catalytic tetrad [active]
349163007254	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
349163007255	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
349163007256	HIGH motif; other site
349163007257	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
349163007258	active site
349163007259	KMSKS motif; other site
349163007260	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
349163007261	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349163007262	active site
349163007263	motif I; other site
349163007264	motif II; other site
349163007265	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349163007266	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
349163007267	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
349163007268	quinone interaction residues [chemical binding]; other site
349163007269	active site
349163007270	catalytic residues [active]
349163007271	FMN binding site [chemical binding]; other site
349163007272	substrate binding site [chemical binding]; other site
349163007273	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
349163007274	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
349163007275	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
349163007276	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
349163007277	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349163007278	inhibitor-cofactor binding pocket; inhibition site
349163007279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163007280	catalytic residue [active]
349163007281	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
349163007282	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
349163007283	tetramerization interface [polypeptide binding]; other site
349163007284	NAD(P) binding site [chemical binding]; other site
349163007285	catalytic residues [active]
349163007286	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
349163007287	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
349163007288	tandem repeat interface [polypeptide binding]; other site
349163007289	oligomer interface [polypeptide binding]; other site
349163007290	active site residues [active]
349163007291	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
349163007292	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
349163007293	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349163007294	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349163007295	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
349163007296	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
349163007297	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349163007298	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163007299	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163007300	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163007301	TM-ABC transporter signature motif; other site
349163007302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163007303	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163007304	Walker A/P-loop; other site
349163007305	ATP binding site [chemical binding]; other site
349163007306	Q-loop/lid; other site
349163007307	ABC transporter signature motif; other site
349163007308	Walker B; other site
349163007309	D-loop; other site
349163007310	H-loop/switch region; other site
349163007311	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
349163007312	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
349163007313	putative ligand binding site [chemical binding]; other site
349163007314	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349163007315	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
349163007316	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163007317	Walker A/P-loop; other site
349163007318	ATP binding site [chemical binding]; other site
349163007319	Q-loop/lid; other site
349163007320	ABC transporter signature motif; other site
349163007321	Walker B; other site
349163007322	D-loop; other site
349163007323	H-loop/switch region; other site
349163007324	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
349163007325	nudix motif; other site
349163007326	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349163007327	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
349163007328	C-terminal domain interface [polypeptide binding]; other site
349163007329	GSH binding site (G-site) [chemical binding]; other site
349163007330	dimer interface [polypeptide binding]; other site
349163007331	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
349163007332	Moco binding site; other site
349163007333	metal coordination site [ion binding]; other site
349163007334	Cytochrome c; Region: Cytochrom_C; cl11414
349163007335	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
349163007336	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
349163007337	TrkA-N domain; Region: TrkA_N; pfam02254
349163007338	glutathione reductase; Validated; Region: PRK06116
349163007339	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349163007340	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349163007341	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349163007342	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
349163007343	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
349163007344	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
349163007345	active site
349163007346	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
349163007347	NAD synthetase; Provisional; Region: PRK13981
349163007348	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
349163007349	multimer interface [polypeptide binding]; other site
349163007350	active site
349163007351	catalytic triad [active]
349163007352	protein interface 1 [polypeptide binding]; other site
349163007353	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
349163007354	homodimer interface [polypeptide binding]; other site
349163007355	NAD binding pocket [chemical binding]; other site
349163007356	ATP binding pocket [chemical binding]; other site
349163007357	Mg binding site [ion binding]; other site
349163007358	active-site loop [active]
349163007359	Hint domain; Region: Hint_2; pfam13403
349163007360	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349163007361	IHF - DNA interface [nucleotide binding]; other site
349163007362	IHF dimer interface [polypeptide binding]; other site
349163007363	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
349163007364	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
349163007365	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
349163007366	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
349163007367	Switch I; other site
349163007368	Switch II; other site
349163007369	septum formation inhibitor; Reviewed; Region: minC; PRK05177
349163007370	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
349163007371	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
349163007372	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
349163007373	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
349163007374	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
349163007375	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
349163007376	active site
349163007377	catalytic triad [active]
349163007378	oxyanion hole [active]
349163007379	OpgC protein; Region: OpgC_C; pfam10129
349163007380	recombination protein RecR; Reviewed; Region: recR; PRK00076
349163007381	RecR protein; Region: RecR; pfam02132
349163007382	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
349163007383	putative active site [active]
349163007384	putative metal-binding site [ion binding]; other site
349163007385	tetramer interface [polypeptide binding]; other site
349163007386	hypothetical protein; Validated; Region: PRK00153
349163007387	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
349163007388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163007389	Walker A motif; other site
349163007390	ATP binding site [chemical binding]; other site
349163007391	Walker B motif; other site
349163007392	arginine finger; other site
349163007393	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
349163007394	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
349163007395	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
349163007396	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
349163007397	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
349163007398	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
349163007399	putative NADH binding site [chemical binding]; other site
349163007400	putative active site [active]
349163007401	nudix motif; other site
349163007402	putative metal binding site [ion binding]; other site
349163007403	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
349163007404	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349163007405	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
349163007406	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349163007407	active site
349163007408	metal binding site [ion binding]; metal-binding site
349163007409	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
349163007410	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
349163007411	Protein of unknown function DUF58; Region: DUF58; pfam01882
349163007412	MoxR-like ATPases [General function prediction only]; Region: COG0714
349163007413	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163007414	Walker A motif; other site
349163007415	ATP binding site [chemical binding]; other site
349163007416	Walker B motif; other site
349163007417	arginine finger; other site
349163007418	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
349163007419	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
349163007420	putative active site [active]
349163007421	putative CoA binding site [chemical binding]; other site
349163007422	nudix motif; other site
349163007423	metal binding site [ion binding]; metal-binding site
349163007424	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
349163007425	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
349163007426	active site
349163007427	NTP binding site [chemical binding]; other site
349163007428	metal binding triad [ion binding]; metal-binding site
349163007429	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
349163007430	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
349163007431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163007432	S-adenosylmethionine binding site [chemical binding]; other site
349163007433	exopolyphosphatase; Region: exo_poly_only; TIGR03706
349163007434	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
349163007435	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
349163007436	TPP-binding site [chemical binding]; other site
349163007437	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
349163007438	PYR/PP interface [polypeptide binding]; other site
349163007439	dimer interface [polypeptide binding]; other site
349163007440	TPP binding site [chemical binding]; other site
349163007441	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
349163007442	30S subunit binding site; other site
349163007443	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
349163007444	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
349163007445	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
349163007446	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
349163007447	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
349163007448	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349163007449	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
349163007450	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349163007451	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
349163007452	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
349163007453	ATP binding site [chemical binding]; other site
349163007454	Walker A motif; other site
349163007455	hexamer interface [polypeptide binding]; other site
349163007456	Walker B motif; other site
349163007457	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
349163007458	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
349163007459	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
349163007460	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
349163007461	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
349163007462	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349163007463	substrate binding site [chemical binding]; other site
349163007464	ATP binding site [chemical binding]; other site
349163007465	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
349163007466	glutathione synthetase; Provisional; Region: PRK05246
349163007467	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
349163007468	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
349163007469	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
349163007470	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
349163007471	active site
349163007472	metal binding site [ion binding]; metal-binding site
349163007473	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
349163007474	isocitrate dehydrogenase; Validated; Region: PRK09222
349163007475	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
349163007476	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163007477	putative substrate translocation pore; other site
349163007478	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
349163007479	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
349163007480	homotrimer interaction site [polypeptide binding]; other site
349163007481	zinc binding site [ion binding]; other site
349163007482	CDP-binding sites; other site
349163007483	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
349163007484	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
349163007485	FMN binding site [chemical binding]; other site
349163007486	active site
349163007487	catalytic residues [active]
349163007488	substrate binding site [chemical binding]; other site
349163007489	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
349163007490	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349163007491	putative active site [active]
349163007492	heme pocket [chemical binding]; other site
349163007493	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349163007494	dimer interface [polypeptide binding]; other site
349163007495	phosphorylation site [posttranslational modification]
349163007496	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163007497	ATP binding site [chemical binding]; other site
349163007498	Mg2+ binding site [ion binding]; other site
349163007499	G-X-G motif; other site
349163007500	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
349163007501	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163007502	active site
349163007503	phosphorylation site [posttranslational modification]
349163007504	intermolecular recognition site; other site
349163007505	dimerization interface [polypeptide binding]; other site
349163007506	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163007507	Walker A motif; other site
349163007508	ATP binding site [chemical binding]; other site
349163007509	Walker B motif; other site
349163007510	arginine finger; other site
349163007511	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
349163007512	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
349163007513	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349163007514	dimerization interface [polypeptide binding]; other site
349163007515	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349163007516	dimer interface [polypeptide binding]; other site
349163007517	phosphorylation site [posttranslational modification]
349163007518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163007519	ATP binding site [chemical binding]; other site
349163007520	Mg2+ binding site [ion binding]; other site
349163007521	G-X-G motif; other site
349163007522	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349163007523	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163007524	active site
349163007525	phosphorylation site [posttranslational modification]
349163007526	intermolecular recognition site; other site
349163007527	dimerization interface [polypeptide binding]; other site
349163007528	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163007529	Walker A motif; other site
349163007530	ATP binding site [chemical binding]; other site
349163007531	Walker B motif; other site
349163007532	arginine finger; other site
349163007533	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349163007534	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
349163007535	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
349163007536	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
349163007537	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
349163007538	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
349163007539	dimer interface [polypeptide binding]; other site
349163007540	ssDNA binding site [nucleotide binding]; other site
349163007541	tetramer (dimer of dimers) interface [polypeptide binding]; other site
349163007542	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
349163007543	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
349163007544	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
349163007545	Predicted transcriptional regulators [Transcription]; Region: COG1510
349163007546	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349163007547	dimerization interface [polypeptide binding]; other site
349163007548	putative DNA binding site [nucleotide binding]; other site
349163007549	putative Zn2+ binding site [ion binding]; other site
349163007550	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
349163007551	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163007552	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163007553	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349163007554	putative effector binding pocket; other site
349163007555	dimerization interface [polypeptide binding]; other site
349163007556	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
349163007557	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
349163007558	putative molybdopterin cofactor binding site [chemical binding]; other site
349163007559	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
349163007560	putative molybdopterin cofactor binding site; other site
349163007561	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349163007562	Methyltransferase domain; Region: Methyltransf_11; pfam08241
349163007563	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
349163007564	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
349163007565	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
349163007566	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
349163007567	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
349163007568	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
349163007569	Lipopolysaccharide-assembly; Region: LptE; cl01125
349163007570	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
349163007571	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
349163007572	HIGH motif; other site
349163007573	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
349163007574	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349163007575	active site
349163007576	KMSKS motif; other site
349163007577	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
349163007578	tRNA binding surface [nucleotide binding]; other site
349163007579	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
349163007580	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
349163007581	Thiamine monophosphate synthase/TENI; Region: TMP-TENI; cl17228
349163007582	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
349163007583	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349163007584	catalytic residue [active]
349163007585	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
349163007586	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
349163007587	NAD binding site [chemical binding]; other site
349163007588	Protein of unknown function (DUF445); Region: DUF445; pfam04286
349163007589	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
349163007590	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
349163007591	active site
349163007592	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
349163007593	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
349163007594	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
349163007595	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349163007596	active site
349163007597	Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582
349163007598	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
349163007599	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
349163007600	Patatin-like phospholipase; Region: Patatin; pfam01734
349163007601	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163007602	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349163007603	putative substrate translocation pore; other site
349163007604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163007605	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
349163007606	TPP-binding site [chemical binding]; other site
349163007607	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
349163007608	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
349163007609	PYR/PP interface [polypeptide binding]; other site
349163007610	dimer interface [polypeptide binding]; other site
349163007611	TPP binding site [chemical binding]; other site
349163007612	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349163007613	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349163007614	putative DNA binding site [nucleotide binding]; other site
349163007615	putative Zn2+ binding site [ion binding]; other site
349163007616	AsnC family; Region: AsnC_trans_reg; pfam01037
349163007617	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163007618	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163007619	metal binding site [ion binding]; metal-binding site
349163007620	active site
349163007621	I-site; other site
349163007622	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163007623	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163007624	D-galactonate transporter; Region: 2A0114; TIGR00893
349163007625	putative substrate translocation pore; other site
349163007626	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
349163007627	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
349163007628	[2Fe-2S] cluster binding site [ion binding]; other site
349163007629	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
349163007630	putative alpha subunit interface [polypeptide binding]; other site
349163007631	putative active site [active]
349163007632	putative substrate binding site [chemical binding]; other site
349163007633	Fe binding site [ion binding]; other site
349163007634	methionine gamma-lyase; Validated; Region: PRK07049
349163007635	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
349163007636	homodimer interface [polypeptide binding]; other site
349163007637	substrate-cofactor binding pocket; other site
349163007638	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163007639	catalytic residue [active]
349163007640	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
349163007641	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
349163007642	hydroxyglutarate oxidase; Provisional; Region: PRK11728
349163007643	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
349163007644	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349163007645	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
349163007646	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163007647	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349163007648	dimerization interface [polypeptide binding]; other site
349163007649	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
349163007650	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349163007651	Walker A/P-loop; other site
349163007652	ATP binding site [chemical binding]; other site
349163007653	Q-loop/lid; other site
349163007654	ABC transporter signature motif; other site
349163007655	Walker B; other site
349163007656	D-loop; other site
349163007657	H-loop/switch region; other site
349163007658	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349163007659	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349163007660	Walker A/P-loop; other site
349163007661	ATP binding site [chemical binding]; other site
349163007662	Q-loop/lid; other site
349163007663	ABC transporter signature motif; other site
349163007664	Walker B; other site
349163007665	D-loop; other site
349163007666	H-loop/switch region; other site
349163007667	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
349163007668	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
349163007669	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163007670	dimer interface [polypeptide binding]; other site
349163007671	conserved gate region; other site
349163007672	putative PBP binding loops; other site
349163007673	ABC-ATPase subunit interface; other site
349163007674	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
349163007675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163007676	dimer interface [polypeptide binding]; other site
349163007677	conserved gate region; other site
349163007678	putative PBP binding loops; other site
349163007679	ABC-ATPase subunit interface; other site
349163007680	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
349163007681	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
349163007682	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349163007683	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349163007684	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
349163007685	putative acyl-acceptor binding pocket; other site
349163007686	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
349163007687	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
349163007688	Paraquat-inducible protein A; Region: PqiA; pfam04403
349163007689	Paraquat-inducible protein A; Region: PqiA; pfam04403
349163007690	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
349163007691	mce related protein; Region: MCE; pfam02470
349163007692	mce related protein; Region: MCE; pfam02470
349163007693	Protein of unknown function (DUF330); Region: DUF330; pfam03886
349163007694	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
349163007695	active site
349163007696	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
349163007697	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
349163007698	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
349163007699	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
349163007700	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
349163007701	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
349163007702	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349163007703	ligand binding site [chemical binding]; other site
349163007704	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
349163007705	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
349163007706	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
349163007707	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
349163007708	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
349163007709	phosphopeptide binding site; other site
349163007710	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
349163007711	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
349163007712	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
349163007713	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
349163007714	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
349163007715	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
349163007716	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
349163007717	Surface antigen; Region: Bac_surface_Ag; pfam01103
349163007718	haemagglutination activity domain; Region: Haemagg_act; pfam05860
349163007719	CHAT domain; Region: CHAT; pfam12770
349163007720	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
349163007721	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349163007722	active site
349163007723	ATP binding site [chemical binding]; other site
349163007724	substrate binding site [chemical binding]; other site
349163007725	activation loop (A-loop); other site
349163007726	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
349163007727	Cytochrome c; Region: Cytochrom_C; cl11414
349163007728	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
349163007729	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
349163007730	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349163007731	ATP binding site [chemical binding]; other site
349163007732	putative Mg++ binding site [ion binding]; other site
349163007733	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349163007734	nucleotide binding region [chemical binding]; other site
349163007735	ATP-binding site [chemical binding]; other site
349163007736	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
349163007737	HRDC domain; Region: HRDC; pfam00570
349163007738	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
349163007739	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349163007740	ligand binding site [chemical binding]; other site
349163007741	flexible hinge region; other site
349163007742	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
349163007743	non-specific DNA interactions [nucleotide binding]; other site
349163007744	DNA binding site [nucleotide binding]
349163007745	sequence specific DNA binding site [nucleotide binding]; other site
349163007746	putative cAMP binding site [chemical binding]; other site
349163007747	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
349163007748	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
349163007749	homodimer interface [polypeptide binding]; other site
349163007750	substrate-cofactor binding pocket; other site
349163007751	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163007752	catalytic residue [active]
349163007753	aminopeptidase N; Provisional; Region: pepN; PRK14015
349163007754	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
349163007755	Zn binding site [ion binding]; other site
349163007756	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
349163007757	Protein of unknown function, DUF482; Region: DUF482; pfam04339
349163007758	CsbD-like; Region: CsbD; pfam05532
349163007759	Transposase, Mutator family; Region: Transposase_mut; pfam00872
349163007760	MULE transposase domain; Region: MULE; pfam10551
349163007761	Amino acid permease; Region: AA_permease_2; pfam13520
349163007762	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
349163007763	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
349163007764	putative glutathione S-transferase; Provisional; Region: PRK10357
349163007765	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
349163007766	putative C-terminal domain interface [polypeptide binding]; other site
349163007767	putative GSH binding site (G-site) [chemical binding]; other site
349163007768	putative dimer interface [polypeptide binding]; other site
349163007769	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
349163007770	dimer interface [polypeptide binding]; other site
349163007771	N-terminal domain interface [polypeptide binding]; other site
349163007772	putative substrate binding pocket (H-site) [chemical binding]; other site
349163007773	Phosphotransferase enzyme family; Region: APH; pfam01636
349163007774	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
349163007775	putative active site [active]
349163007776	putative substrate binding site [chemical binding]; other site
349163007777	ATP binding site [chemical binding]; other site
349163007778	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349163007779	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349163007780	active site
349163007781	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
349163007782	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
349163007783	NAD(P) binding site [chemical binding]; other site
349163007784	hypothetical protein; Provisional; Region: PRK06194
349163007785	classical (c) SDRs; Region: SDR_c; cd05233
349163007786	NAD(P) binding site [chemical binding]; other site
349163007787	active site
349163007788	thiamine monophosphate kinase; Provisional; Region: PRK05731
349163007789	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
349163007790	ATP binding site [chemical binding]; other site
349163007791	dimerization interface [polypeptide binding]; other site
349163007792	transcription antitermination factor NusB; Region: nusB; TIGR01951
349163007793	putative RNA binding site [nucleotide binding]; other site
349163007794	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
349163007795	homopentamer interface [polypeptide binding]; other site
349163007796	active site
349163007797	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
349163007798	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
349163007799	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
349163007800	dimerization interface [polypeptide binding]; other site
349163007801	active site
349163007802	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
349163007803	Lumazine binding domain; Region: Lum_binding; pfam00677
349163007804	Lumazine binding domain; Region: Lum_binding; pfam00677
349163007805	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
349163007806	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
349163007807	catalytic motif [active]
349163007808	Zn binding site [ion binding]; other site
349163007809	RibD C-terminal domain; Region: RibD_C; cl17279
349163007810	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
349163007811	ATP cone domain; Region: ATP-cone; pfam03477
349163007812	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
349163007813	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
349163007814	dimer interface [polypeptide binding]; other site
349163007815	active site
349163007816	glycine-pyridoxal phosphate binding site [chemical binding]; other site
349163007817	folate binding site [chemical binding]; other site
349163007818	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
349163007819	Uncharacterized conserved protein [Function unknown]; Region: COG2835
349163007820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
349163007821	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
349163007822	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349163007823	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
349163007824	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
349163007825	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
349163007826	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
349163007827	Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313
349163007828	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
349163007829	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
349163007830	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
349163007831	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349163007832	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
349163007833	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
349163007834	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349163007835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163007836	ATP binding site [chemical binding]; other site
349163007837	Mg2+ binding site [ion binding]; other site
349163007838	G-X-G motif; other site
349163007839	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
349163007840	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
349163007841	active site
349163007842	nucleophile elbow; other site
349163007843	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
349163007844	Ribonuclease P; Region: Ribonuclease_P; pfam00825
349163007845	Haemolytic domain; Region: Haemolytic; pfam01809
349163007846	membrane protein insertase; Provisional; Region: PRK01318
349163007847	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
349163007848	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
349163007849	G1 box; other site
349163007850	GTP/Mg2+ binding site [chemical binding]; other site
349163007851	Switch I region; other site
349163007852	G2 box; other site
349163007853	G3 box; other site
349163007854	Switch II region; other site
349163007855	G4 box; other site
349163007856	G5 box; other site
349163007857	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
349163007858	feedback inhibition sensing region; other site
349163007859	homohexameric interface [polypeptide binding]; other site
349163007860	nucleotide binding site [chemical binding]; other site
349163007861	N-acetyl-L-glutamate binding site [chemical binding]; other site
349163007862	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349163007863	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349163007864	dimer interface [polypeptide binding]; other site
349163007865	putative CheW interface [polypeptide binding]; other site
349163007866	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
349163007867	Domain of unknown function DUF21; Region: DUF21; pfam01595
349163007868	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
349163007869	Transporter associated domain; Region: CorC_HlyC; smart01091
349163007870	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
349163007871	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
349163007872	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349163007873	active site
349163007874	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
349163007875	tartrate dehydrogenase; Region: TTC; TIGR02089
349163007876	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
349163007877	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
349163007878	substrate binding site [chemical binding]; other site
349163007879	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
349163007880	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
349163007881	substrate binding site [chemical binding]; other site
349163007882	ligand binding site [chemical binding]; other site
349163007883	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
349163007884	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
349163007885	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
349163007886	RimM N-terminal domain; Region: RimM; pfam01782
349163007887	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
349163007888	signal recognition particle protein; Provisional; Region: PRK10867
349163007889	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
349163007890	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
349163007891	P loop; other site
349163007892	GTP binding site [chemical binding]; other site
349163007893	Signal peptide binding domain; Region: SRP_SPB; pfam02978
349163007894	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
349163007895	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
349163007896	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
349163007897	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
349163007898	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
349163007899	ligand binding site [chemical binding]; other site
349163007900	homodimer interface [polypeptide binding]; other site
349163007901	NAD(P) binding site [chemical binding]; other site
349163007902	trimer interface B [polypeptide binding]; other site
349163007903	trimer interface A [polypeptide binding]; other site
349163007904	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
349163007905	Clp protease; Region: CLP_protease; pfam00574
349163007906	oligomer interface [polypeptide binding]; other site
349163007907	active site residues [active]
349163007908	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
349163007909	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163007910	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
349163007911	putative dimerization interface [polypeptide binding]; other site
349163007912	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
349163007913	putative hydrophobic ligand binding site [chemical binding]; other site
349163007914	protein interface [polypeptide binding]; other site
349163007915	gate; other site
349163007916	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
349163007917	DNA-binding site [nucleotide binding]; DNA binding site
349163007918	Transcriptional regulators [Transcription]; Region: FadR; COG2186
349163007919	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
349163007920	DNA-binding site [nucleotide binding]; DNA binding site
349163007921	FCD domain; Region: FCD; pfam07729
349163007922	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
349163007923	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
349163007924	active site
349163007925	Zn binding site [ion binding]; other site
349163007926	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
349163007927	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
349163007928	Subunit III/VIIa interface [polypeptide binding]; other site
349163007929	Phospholipid binding site [chemical binding]; other site
349163007930	Subunit I/III interface [polypeptide binding]; other site
349163007931	Subunit III/VIb interface [polypeptide binding]; other site
349163007932	Subunit III/VIa interface; other site
349163007933	Subunit III/Vb interface [polypeptide binding]; other site
349163007934	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
349163007935	UbiA prenyltransferase family; Region: UbiA; pfam01040
349163007936	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
349163007937	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
349163007938	Subunit I/III interface [polypeptide binding]; other site
349163007939	D-pathway; other site
349163007940	Subunit I/VIIc interface [polypeptide binding]; other site
349163007941	Subunit I/IV interface [polypeptide binding]; other site
349163007942	Subunit I/II interface [polypeptide binding]; other site
349163007943	Low-spin heme (heme a) binding site [chemical binding]; other site
349163007944	Subunit I/VIIa interface [polypeptide binding]; other site
349163007945	Subunit I/VIa interface [polypeptide binding]; other site
349163007946	Dimer interface; other site
349163007947	Putative water exit pathway; other site
349163007948	Binuclear center (heme a3/CuB) [ion binding]; other site
349163007949	K-pathway; other site
349163007950	Subunit I/Vb interface [polypeptide binding]; other site
349163007951	Putative proton exit pathway; other site
349163007952	Subunit I/VIb interface; other site
349163007953	Subunit I/VIc interface [polypeptide binding]; other site
349163007954	Electron transfer pathway; other site
349163007955	Subunit I/VIIIb interface [polypeptide binding]; other site
349163007956	Subunit I/VIIb interface [polypeptide binding]; other site
349163007957	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
349163007958	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
349163007959	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
349163007960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163007961	GcrA cell cycle regulator; Region: GcrA; cl11564
349163007962	Bacterial SH3 domain; Region: SH3_4; pfam06347
349163007963	Bacterial SH3 domain; Region: SH3_4; pfam06347
349163007964	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
349163007965	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
349163007966	ATP binding site [chemical binding]; other site
349163007967	substrate interface [chemical binding]; other site
349163007968	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
349163007969	FMN binding site [chemical binding]; other site
349163007970	substrate binding site [chemical binding]; other site
349163007971	putative catalytic residue [active]
349163007972	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
349163007973	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349163007974	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349163007975	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
349163007976	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163007977	catalytic loop [active]
349163007978	iron binding site [ion binding]; other site
349163007979	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
349163007980	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
349163007981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163007982	metabolite-proton symporter; Region: 2A0106; TIGR00883
349163007983	putative substrate translocation pore; other site
349163007984	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349163007985	dimer interface [polypeptide binding]; other site
349163007986	phosphorylation site [posttranslational modification]
349163007987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163007988	ATP binding site [chemical binding]; other site
349163007989	Mg2+ binding site [ion binding]; other site
349163007990	G-X-G motif; other site
349163007991	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349163007992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163007993	active site
349163007994	phosphorylation site [posttranslational modification]
349163007995	intermolecular recognition site; other site
349163007996	dimerization interface [polypeptide binding]; other site
349163007997	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163007998	DNA binding site [nucleotide binding]
349163007999	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
349163008000	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
349163008001	dimer interface [polypeptide binding]; other site
349163008002	active site
349163008003	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349163008004	catalytic residues [active]
349163008005	substrate binding site [chemical binding]; other site
349163008006	Dienelactone hydrolase family; Region: DLH; pfam01738
349163008007	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
349163008008	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
349163008009	Probable Catalytic site; other site
349163008010	metal-binding site
349163008011	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
349163008012	pyruvate phosphate dikinase; Provisional; Region: PRK09279
349163008013	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
349163008014	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
349163008015	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
349163008016	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
349163008017	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
349163008018	dimer interface [polypeptide binding]; other site
349163008019	motif 1; other site
349163008020	active site
349163008021	motif 2; other site
349163008022	motif 3; other site
349163008023	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349163008024	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
349163008025	substrate binding site [chemical binding]; other site
349163008026	FAD binding site [chemical binding]; other site
349163008027	catalytic base [active]
349163008028	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
349163008029	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255
349163008030	spermidine synthase; Provisional; Region: PRK00811
349163008031	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349163008032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163008033	S-adenosylmethionine binding site [chemical binding]; other site
349163008034	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675
349163008035	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349163008036	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163008037	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
349163008038	putative ADP-binding pocket [chemical binding]; other site
349163008039	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
349163008040	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
349163008041	putative active site [active]
349163008042	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
349163008043	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
349163008044	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
349163008045	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
349163008046	active site
349163008047	dimer interface [polypeptide binding]; other site
349163008048	motif 1; other site
349163008049	motif 2; other site
349163008050	motif 3; other site
349163008051	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
349163008052	anticodon binding site; other site
349163008053	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
349163008054	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
349163008055	Bacterial transcriptional regulator; Region: IclR; pfam01614
349163008056	OsmC-like protein; Region: OsmC; pfam02566
349163008057	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
349163008058	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
349163008059	Walker A/P-loop; other site
349163008060	ATP binding site [chemical binding]; other site
349163008061	Q-loop/lid; other site
349163008062	ABC transporter signature motif; other site
349163008063	Walker B; other site
349163008064	D-loop; other site
349163008065	H-loop/switch region; other site
349163008066	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163008067	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
349163008068	Walker A/P-loop; other site
349163008069	ATP binding site [chemical binding]; other site
349163008070	Q-loop/lid; other site
349163008071	ABC transporter signature motif; other site
349163008072	Walker B; other site
349163008073	D-loop; other site
349163008074	H-loop/switch region; other site
349163008075	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
349163008076	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
349163008077	TM-ABC transporter signature motif; other site
349163008078	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163008079	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
349163008080	TM-ABC transporter signature motif; other site
349163008081	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349163008082	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
349163008083	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
349163008084	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
349163008085	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
349163008086	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
349163008087	THF binding site; other site
349163008088	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
349163008089	substrate binding site [chemical binding]; other site
349163008090	THF binding site; other site
349163008091	zinc-binding site [ion binding]; other site
349163008092	major facilitator superfamily transporter; Provisional; Region: PRK05122
349163008093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163008094	dihydroxy-acid dehydratase; Validated; Region: PRK06131
349163008095	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
349163008096	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349163008097	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349163008098	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
349163008099	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
349163008100	Probable Catalytic site; other site
349163008101	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163008102	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163008103	TM-ABC transporter signature motif; other site
349163008104	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163008105	TM-ABC transporter signature motif; other site
349163008106	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
349163008107	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163008108	Walker A/P-loop; other site
349163008109	ATP binding site [chemical binding]; other site
349163008110	Q-loop/lid; other site
349163008111	ABC transporter signature motif; other site
349163008112	Walker B; other site
349163008113	D-loop; other site
349163008114	H-loop/switch region; other site
349163008115	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349163008116	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
349163008117	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
349163008118	putative ligand binding site [chemical binding]; other site
349163008119	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
349163008120	Predicted transcriptional regulators [Transcription]; Region: COG1695
349163008121	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
349163008122	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
349163008123	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
349163008124	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
349163008125	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
349163008126	metal binding site [ion binding]; metal-binding site
349163008127	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
349163008128	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
349163008129	metal binding site [ion binding]; metal-binding site
349163008130	putative dimer interface [polypeptide binding]; other site
349163008131	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163008132	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163008133	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
349163008134	putative effector binding pocket; other site
349163008135	putative dimerization interface [polypeptide binding]; other site
349163008136	short chain dehydrogenase; Provisional; Region: PRK12939
349163008137	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163008138	NAD(P) binding site [chemical binding]; other site
349163008139	active site
349163008140	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
349163008141	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
349163008142	hypothetical protein; Provisional; Region: PRK06815
349163008143	tetramer interface [polypeptide binding]; other site
349163008144	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163008145	catalytic residue [active]
349163008146	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163008147	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163008148	TM-ABC transporter signature motif; other site
349163008149	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163008150	TM-ABC transporter signature motif; other site
349163008151	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
349163008152	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163008153	Walker A/P-loop; other site
349163008154	ATP binding site [chemical binding]; other site
349163008155	Q-loop/lid; other site
349163008156	ABC transporter signature motif; other site
349163008157	Walker B; other site
349163008158	D-loop; other site
349163008159	H-loop/switch region; other site
349163008160	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349163008161	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
349163008162	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
349163008163	putative ligand binding site [chemical binding]; other site
349163008164	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
349163008165	Transcriptional regulator [Transcription]; Region: IclR; COG1414
349163008166	Bacterial transcriptional regulator; Region: IclR; pfam01614
349163008167	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
349163008168	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
349163008169	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
349163008170	Transcriptional regulators [Transcription]; Region: GntR; COG1802
349163008171	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349163008172	DNA-binding site [nucleotide binding]; DNA binding site
349163008173	FCD domain; Region: FCD; pfam07729
349163008174	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
349163008175	Fasciclin domain; Region: Fasciclin; pfam02469
349163008176	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
349163008177	heterotetramer interface [polypeptide binding]; other site
349163008178	active site pocket [active]
349163008179	cleavage site
349163008180	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
349163008181	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
349163008182	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
349163008183	SEC-C motif; Region: SEC-C; pfam02810
349163008184	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
349163008185	MarR family; Region: MarR; pfam01047
349163008186	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
349163008187	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
349163008188	23S rRNA interface [nucleotide binding]; other site
349163008189	L3 interface [polypeptide binding]; other site
349163008190	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163008191	active site
349163008192	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
349163008193	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
349163008194	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
349163008195	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
349163008196	putative acyltransferase; Provisional; Region: PRK05790
349163008197	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
349163008198	dimer interface [polypeptide binding]; other site
349163008199	active site
349163008200	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
349163008201	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
349163008202	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
349163008203	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349163008204	inhibitor-cofactor binding pocket; inhibition site
349163008205	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163008206	catalytic residue [active]
349163008207	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
349163008208	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349163008209	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163008210	non-specific DNA binding site [nucleotide binding]; other site
349163008211	salt bridge; other site
349163008212	sequence-specific DNA binding site [nucleotide binding]; other site
349163008213	3-mercaptopyruvate sulfurtransferase; Region: PLN02723
349163008214	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
349163008215	active site residue [active]
349163008216	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
349163008217	active site residue [active]
349163008218	cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324
349163008219	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349163008220	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349163008221	catalytic residue [active]
349163008222	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
349163008223	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
349163008224	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
349163008225	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
349163008226	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
349163008227	trimerization site [polypeptide binding]; other site
349163008228	active site
349163008229	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
349163008230	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
349163008231	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349163008232	catalytic residue [active]
349163008233	FeS assembly protein SufD; Region: sufD; TIGR01981
349163008234	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
349163008235	FeS assembly ATPase SufC; Region: sufC; TIGR01978
349163008236	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
349163008237	Walker A/P-loop; other site
349163008238	ATP binding site [chemical binding]; other site
349163008239	Q-loop/lid; other site
349163008240	ABC transporter signature motif; other site
349163008241	Walker B; other site
349163008242	D-loop; other site
349163008243	H-loop/switch region; other site
349163008244	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
349163008245	putative ABC transporter; Region: ycf24; CHL00085
349163008246	Transcriptional regulator; Region: Rrf2; pfam02082
349163008247	phosphoglycolate phosphatase; Provisional; Region: PRK13222
349163008248	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349163008249	motif II; other site
349163008250	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
349163008251	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349163008252	active site
349163008253	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
349163008254	active site
349163008255	substrate binding site [chemical binding]; other site
349163008256	CoA binding site [chemical binding]; other site
349163008257	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
349163008258	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
349163008259	glutaminase active site [active]
349163008260	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
349163008261	dimer interface [polypeptide binding]; other site
349163008262	active site
349163008263	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
349163008264	dimer interface [polypeptide binding]; other site
349163008265	active site
349163008266	V4R domain; Region: V4R; cl15268
349163008267	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
349163008268	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
349163008269	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163008270	FeS/SAM binding site; other site
349163008271	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349163008272	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
349163008273	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
349163008274	putative substrate binding pocket [chemical binding]; other site
349163008275	AC domain interface; other site
349163008276	catalytic triad [active]
349163008277	AB domain interface; other site
349163008278	interchain disulfide; other site
349163008279	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349163008280	acetyl-CoA synthetase; Provisional; Region: PRK00174
349163008281	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
349163008282	active site
349163008283	CoA binding site [chemical binding]; other site
349163008284	acyl-activating enzyme (AAE) consensus motif; other site
349163008285	AMP binding site [chemical binding]; other site
349163008286	acetate binding site [chemical binding]; other site
349163008287	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
349163008288	Malic enzyme, N-terminal domain; Region: malic; pfam00390
349163008289	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
349163008290	putative NAD(P) binding site [chemical binding]; other site
349163008291	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
349163008292	lipoate-protein ligase B; Provisional; Region: PRK14341
349163008293	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
349163008294	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
349163008295	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
349163008296	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
349163008297	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163008298	Walker A motif; other site
349163008299	ATP binding site [chemical binding]; other site
349163008300	Walker B motif; other site
349163008301	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349163008302	Integrase core domain; Region: rve; pfam00665
349163008303	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349163008304	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
349163008305	polymerase nucleotide-binding site; other site
349163008306	DNA-binding residues [nucleotide binding]; DNA binding site
349163008307	nucleotide binding site [chemical binding]; other site
349163008308	primase nucleotide-binding site [nucleotide binding]; other site
349163008309	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
349163008310	active site
349163008311	Int/Topo IB signature motif; other site
349163008312	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349163008313	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349163008314	Integrase core domain; Region: rve; pfam00665
349163008315	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
349163008316	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
349163008317	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
349163008318	PYR/PP interface [polypeptide binding]; other site
349163008319	dimer interface [polypeptide binding]; other site
349163008320	TPP binding site [chemical binding]; other site
349163008321	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349163008322	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
349163008323	TPP-binding site [chemical binding]; other site
349163008324	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349163008325	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
349163008326	substrate binding site [chemical binding]; other site
349163008327	ATP binding site [chemical binding]; other site
349163008328	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
349163008329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
349163008330	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
349163008331	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349163008332	Walker A/P-loop; other site
349163008333	ATP binding site [chemical binding]; other site
349163008334	Q-loop/lid; other site
349163008335	ABC transporter signature motif; other site
349163008336	Walker B; other site
349163008337	D-loop; other site
349163008338	H-loop/switch region; other site
349163008339	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163008340	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163008341	TM-ABC transporter signature motif; other site
349163008342	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
349163008343	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163008344	putative ligand binding site [chemical binding]; other site
349163008345	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
349163008346	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
349163008347	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
349163008348	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
349163008349	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
349163008350	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
349163008351	DNA interaction; other site
349163008352	Metal-binding active site; metal-binding site
349163008353	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349163008354	DNA binding site [nucleotide binding]
349163008355	domain linker motif; other site
349163008356	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
349163008357	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163008358	putative ligand binding site [chemical binding]; other site
349163008359	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
349163008360	short chain dehydrogenase; Provisional; Region: PRK06198
349163008361	classical (c) SDRs; Region: SDR_c; cd05233
349163008362	NAD(P) binding site [chemical binding]; other site
349163008363	active site
349163008364	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
349163008365	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
349163008366	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
349163008367	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
349163008368	putative active site [active]
349163008369	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
349163008370	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
349163008371	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
349163008372	ligand binding site [chemical binding]; other site
349163008373	NAD binding site [chemical binding]; other site
349163008374	dimerization interface [polypeptide binding]; other site
349163008375	catalytic site [active]
349163008376	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
349163008377	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
349163008378	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
349163008379	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
349163008380	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
349163008381	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
349163008382	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
349163008383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
349163008384	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
349163008385	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
349163008386	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349163008387	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163008388	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163008389	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349163008390	dimerization interface [polypeptide binding]; other site
349163008391	RNA polymerase sigma factor; Reviewed; Region: PRK05602
349163008392	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349163008393	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
349163008394	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
349163008395	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
349163008396	DNA photolyase; Region: DNA_photolyase; pfam00875
349163008397	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
349163008398	Transposase; Region: DDE_Tnp_ISL3; pfam01610
349163008399	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
349163008400	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349163008401	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
349163008402	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
349163008403	Int/Topo IB signature motif; other site
349163008404	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
349163008405	Putative transposase; Region: Y2_Tnp; pfam04986
349163008406	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
349163008407	heme-binding site [chemical binding]; other site
349163008408	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
349163008409	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349163008410	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
349163008411	catalytic residues [active]
349163008412	catalytic nucleophile [active]
349163008413	Recombinase; Region: Recombinase; pfam07508
349163008414	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
349163008415	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349163008416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163008417	NAD(P) binding site [chemical binding]; other site
349163008418	active site
349163008419	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
349163008420	dimer interface [polypeptide binding]; other site
349163008421	active site
349163008422	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
349163008423	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163008424	NAD(P) binding site [chemical binding]; other site
349163008425	active site
349163008426	SOUL heme-binding protein; Region: SOUL; pfam04832
349163008427	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
349163008428	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349163008429	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
349163008430	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349163008431	haemagglutination activity domain; Region: Haemagg_act; cl05436
349163008432	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
349163008433	metal binding site 2 [ion binding]; metal-binding site
349163008434	putative DNA binding helix; other site
349163008435	metal binding site 1 [ion binding]; metal-binding site
349163008436	structural Zn2+ binding site [ion binding]; other site
349163008437	AMP-binding domain protein; Validated; Region: PRK08315
349163008438	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349163008439	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
349163008440	acyl-activating enzyme (AAE) consensus motif; other site
349163008441	putative AMP binding site [chemical binding]; other site
349163008442	putative active site [active]
349163008443	putative CoA binding site [chemical binding]; other site
349163008444	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349163008445	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
349163008446	NADP binding site [chemical binding]; other site
349163008447	dimer interface [polypeptide binding]; other site
349163008448	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
349163008449	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
349163008450	dimer interface [polypeptide binding]; other site
349163008451	anticodon binding site; other site
349163008452	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
349163008453	motif 1; other site
349163008454	dimer interface [polypeptide binding]; other site
349163008455	active site
349163008456	motif 2; other site
349163008457	GAD domain; Region: GAD; pfam02938
349163008458	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
349163008459	active site
349163008460	motif 3; other site
349163008461	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
349163008462	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
349163008463	catalytic site [active]
349163008464	putative active site [active]
349163008465	putative substrate binding site [chemical binding]; other site
349163008466	HRDC domain; Region: HRDC; pfam00570
349163008467	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
349163008468	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
349163008469	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
349163008470	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
349163008471	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
349163008472	intersubunit interface [polypeptide binding]; other site
349163008473	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
349163008474	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
349163008475	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
349163008476	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
349163008477	MOFRL family; Region: MOFRL; pfam05161
349163008478	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
349163008479	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
349163008480	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
349163008481	motif 1; other site
349163008482	dimer interface [polypeptide binding]; other site
349163008483	active site
349163008484	motif 2; other site
349163008485	motif 3; other site
349163008486	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
349163008487	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163008488	FeS/SAM binding site; other site
349163008489	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
349163008490	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
349163008491	Dehydroquinase class II; Region: DHquinase_II; pfam01220
349163008492	trimer interface [polypeptide binding]; other site
349163008493	active site
349163008494	dimer interface [polypeptide binding]; other site
349163008495	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
349163008496	carboxyltransferase (CT) interaction site; other site
349163008497	biotinylation site [posttranslational modification]; other site
349163008498	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
349163008499	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349163008500	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349163008501	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
349163008502	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
349163008503	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163008504	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163008505	metal binding site [ion binding]; metal-binding site
349163008506	active site
349163008507	I-site; other site
349163008508	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163008509	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
349163008510	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
349163008511	putative molybdopterin cofactor binding site [chemical binding]; other site
349163008512	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
349163008513	putative molybdopterin cofactor binding site; other site
349163008514	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
349163008515	amphipathic channel; other site
349163008516	Asn-Pro-Ala signature motifs; other site
349163008517	glycerol kinase; Provisional; Region: glpK; PRK00047
349163008518	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
349163008519	N- and C-terminal domain interface [polypeptide binding]; other site
349163008520	active site
349163008521	MgATP binding site [chemical binding]; other site
349163008522	catalytic site [active]
349163008523	metal binding site [ion binding]; metal-binding site
349163008524	putative homotetramer interface [polypeptide binding]; other site
349163008525	glycerol binding site [chemical binding]; other site
349163008526	homodimer interface [polypeptide binding]; other site
349163008527	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
349163008528	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
349163008529	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
349163008530	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
349163008531	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
349163008532	heme-binding site [chemical binding]; other site
349163008533	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349163008534	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349163008535	dimer interface [polypeptide binding]; other site
349163008536	putative CheW interface [polypeptide binding]; other site
349163008537	putative S-transferase; Provisional; Region: PRK11752
349163008538	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
349163008539	C-terminal domain interface [polypeptide binding]; other site
349163008540	GSH binding site (G-site) [chemical binding]; other site
349163008541	dimer interface [polypeptide binding]; other site
349163008542	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
349163008543	dimer interface [polypeptide binding]; other site
349163008544	N-terminal domain interface [polypeptide binding]; other site
349163008545	active site
349163008546	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
349163008547	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
349163008548	NAD(P) binding site [chemical binding]; other site
349163008549	catalytic residues [active]
349163008550	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
349163008551	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
349163008552	tetrameric interface [polypeptide binding]; other site
349163008553	NAD binding site [chemical binding]; other site
349163008554	catalytic residues [active]
349163008555	substrate binding site [chemical binding]; other site
349163008556	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
349163008557	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
349163008558	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349163008559	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349163008560	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
349163008561	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
349163008562	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
349163008563	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
349163008564	putative active site [active]
349163008565	metal binding site [ion binding]; metal-binding site
349163008566	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163008567	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163008568	metal binding site [ion binding]; metal-binding site
349163008569	active site
349163008570	I-site; other site
349163008571	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
349163008572	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
349163008573	putative active site [active]
349163008574	putative PHP Thumb interface [polypeptide binding]; other site
349163008575	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
349163008576	generic binding surface II; other site
349163008577	generic binding surface I; other site
349163008578	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
349163008579	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
349163008580	active site
349163008581	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
349163008582	classical (c) SDRs; Region: SDR_c; cd05233
349163008583	NAD(P) binding site [chemical binding]; other site
349163008584	active site
349163008585	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349163008586	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
349163008587	putative NAD(P) binding site [chemical binding]; other site
349163008588	active site
349163008589	putative substrate binding site [chemical binding]; other site
349163008590	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
349163008591	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349163008592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163008593	amidase; Provisional; Region: PRK07486
349163008594	Amidase; Region: Amidase; cl11426
349163008595	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
349163008596	ParB-like nuclease domain; Region: ParB; smart00470
349163008597	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349163008598	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349163008599	P-loop; other site
349163008600	Magnesium ion binding site [ion binding]; other site
349163008601	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349163008602	Magnesium ion binding site [ion binding]; other site
349163008603	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
349163008604	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
349163008605	Glucose inhibited division protein A; Region: GIDA; pfam01134
349163008606	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349163008607	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
349163008608	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
349163008609	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
349163008610	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
349163008611	trmE is a tRNA modification GTPase; Region: trmE; cd04164
349163008612	G1 box; other site
349163008613	Switch I region; other site
349163008614	G2 box; other site
349163008615	Switch II region; other site
349163008616	G3 box; other site
349163008617	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
349163008618	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
349163008619	dimer interface [polypeptide binding]; other site
349163008620	[2Fe-2S] cluster binding site [ion binding]; other site
349163008621	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
349163008622	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
349163008623	catalytic residues [active]
349163008624	Domain of unknown function DUF59; Region: DUF59; pfam01883
349163008625	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
349163008626	DNA polymerase III subunit chi; Validated; Region: PRK05728
349163008627	TPR repeat; Region: TPR_11; pfam13414
349163008628	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349163008629	binding surface
349163008630	TPR motif; other site
349163008631	Tetratricopeptide repeat; Region: TPR_16; pfam13432
349163008632	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163008633	flavoprotein, HI0933 family; Region: TIGR00275
349163008634	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163008635	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
349163008636	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
349163008637	putative dimerization interface [polypeptide binding]; other site
349163008638	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
349163008639	Mg++ binding site [ion binding]; other site
349163008640	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
349163008641	putative catalytic motif [active]
349163008642	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
349163008643	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
349163008644	Putative Catalytic site; other site
349163008645	DXD motif; other site
349163008646	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
349163008647	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
349163008648	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
349163008649	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
349163008650	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
349163008651	TrwC relaxase; Region: TrwC; pfam08751
349163008652	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
349163008653	AAA domain; Region: AAA_30; pfam13604
349163008654	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349163008655	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
349163008656	Walker A motif; other site
349163008657	ATP binding site [chemical binding]; other site
349163008658	Walker B motif; other site
349163008659	integrase; Provisional; Region: PRK09692
349163008660	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
349163008661	active site
349163008662	Int/Topo IB signature motif; other site
349163008663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
349163008664	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
349163008665	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
349163008666	Transcriptional regulators [Transcription]; Region: PurR; COG1609
349163008667	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349163008668	DNA binding site [nucleotide binding]
349163008669	domain linker motif; other site
349163008670	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
349163008671	putative dimerization interface [polypeptide binding]; other site
349163008672	putative ligand binding site [chemical binding]; other site
349163008673	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
349163008674	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
349163008675	putative aldolase; Validated; Region: PRK08130
349163008676	intersubunit interface [polypeptide binding]; other site
349163008677	active site
349163008678	Zn2+ binding site [ion binding]; other site
349163008679	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
349163008680	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
349163008681	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163008682	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349163008683	putative substrate translocation pore; other site
349163008684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163008685	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
349163008686	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
349163008687	dimer interface [polypeptide binding]; other site
349163008688	PYR/PP interface [polypeptide binding]; other site
349163008689	TPP binding site [chemical binding]; other site
349163008690	substrate binding site [chemical binding]; other site
349163008691	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
349163008692	TPP-binding site [chemical binding]; other site
349163008693	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
349163008694	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
349163008695	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
349163008696	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163008697	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163008698	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349163008699	putative effector binding pocket; other site
349163008700	dimerization interface [polypeptide binding]; other site
349163008701	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
349163008702	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349163008703	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349163008704	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349163008705	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349163008706	putative DNA binding site [nucleotide binding]; other site
349163008707	putative Zn2+ binding site [ion binding]; other site
349163008708	AsnC family; Region: AsnC_trans_reg; pfam01037
349163008709	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
349163008710	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
349163008711	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349163008712	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349163008713	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349163008714	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349163008715	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349163008716	Surface antigen; Region: Bac_surface_Ag; pfam01103
349163008717	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
349163008718	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
349163008719	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
349163008720	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
349163008721	trimer interface [polypeptide binding]; other site
349163008722	active site
349163008723	UDP-GlcNAc binding site [chemical binding]; other site
349163008724	lipid binding site [chemical binding]; lipid-binding site
349163008725	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
349163008726	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
349163008727	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
349163008728	active site
349163008729	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
349163008730	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
349163008731	dimer interface [polypeptide binding]; other site
349163008732	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349163008733	active site
349163008734	metal binding site [ion binding]; metal-binding site
349163008735	glutathione binding site [chemical binding]; other site
349163008736	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
349163008737	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
349163008738	Transposase; Region: DDE_Tnp_ISL3; pfam01610
349163008739	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349163008740	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
349163008741	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163008742	Walker A/P-loop; other site
349163008743	ATP binding site [chemical binding]; other site
349163008744	Q-loop/lid; other site
349163008745	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349163008746	ABC transporter; Region: ABC_tran_2; pfam12848
349163008747	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349163008748	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
349163008749	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
349163008750	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
349163008751	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
349163008752	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349163008753	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
349163008754	acyl-activating enzyme (AAE) consensus motif; other site
349163008755	putative AMP binding site [chemical binding]; other site
349163008756	putative active site [active]
349163008757	putative CoA binding site [chemical binding]; other site
349163008758	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
349163008759	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
349163008760	metal-binding site [ion binding]
349163008761	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
349163008762	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
349163008763	metal-binding site [ion binding]
349163008764	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349163008765	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
349163008766	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
349163008767	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163008768	NAD(P) binding site [chemical binding]; other site
349163008769	active site
349163008770	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
349163008771	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
349163008772	inhibitor site; inhibition site
349163008773	active site
349163008774	dimer interface [polypeptide binding]; other site
349163008775	catalytic residue [active]
349163008776	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
349163008777	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
349163008778	putative ligand binding site [chemical binding]; other site
349163008779	NAD binding site [chemical binding]; other site
349163008780	catalytic site [active]
349163008781	dihydroxy-acid dehydratase; Validated; Region: PRK06131
349163008782	hypothetical protein; Validated; Region: PRK08245
349163008783	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
349163008784	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
349163008785	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349163008786	motif II; other site
349163008787	Ferrochelatase; Region: Ferrochelatase; pfam00762
349163008788	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
349163008789	C-terminal domain interface [polypeptide binding]; other site
349163008790	active site
349163008791	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
349163008792	active site
349163008793	N-terminal domain interface [polypeptide binding]; other site
349163008794	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
349163008795	substrate binding site [chemical binding]; other site
349163008796	active site
349163008797	PEP synthetase regulatory protein; Provisional; Region: PRK05339
349163008798	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
349163008799	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
349163008800	DNA binding site [nucleotide binding]
349163008801	active site
349163008802	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
349163008803	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
349163008804	NADP binding site [chemical binding]; other site
349163008805	dimer interface [polypeptide binding]; other site
349163008806	CHRD domain; Region: CHRD; pfam07452
349163008807	Dihydroneopterin aldolase; Region: FolB; smart00905
349163008808	active site
349163008809	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
349163008810	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
349163008811	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
349163008812	tetramer interface [polypeptide binding]; other site
349163008813	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
349163008814	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
349163008815	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
349163008816	Sel1-like repeats; Region: SEL1; smart00671
349163008817	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
349163008818	dimer interface [polypeptide binding]; other site
349163008819	substrate binding site [chemical binding]; other site
349163008820	metal binding sites [ion binding]; metal-binding site
349163008821	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163008822	NADH(P)-binding; Region: NAD_binding_10; pfam13460
349163008823	NAD(P) binding site [chemical binding]; other site
349163008824	active site
349163008825	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
349163008826	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
349163008827	Cell division protein ZapA; Region: ZapA; pfam05164
349163008828	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
349163008829	aspartate aminotransferase; Provisional; Region: PRK06108
349163008830	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349163008831	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163008832	homodimer interface [polypeptide binding]; other site
349163008833	catalytic residue [active]
349163008834	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
349163008835	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
349163008836	P loop; other site
349163008837	GTP binding site [chemical binding]; other site
349163008838	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
349163008839	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
349163008840	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163008841	FeS/SAM binding site; other site
349163008842	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
349163008843	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
349163008844	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
349163008845	amino acid transporter; Region: 2A0306; TIGR00909
349163008846	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
349163008847	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
349163008848	minor groove reading motif; other site
349163008849	helix-hairpin-helix signature motif; other site
349163008850	substrate binding pocket [chemical binding]; other site
349163008851	active site
349163008852	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
349163008853	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
349163008854	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163008855	putative substrate translocation pore; other site
349163008856	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
349163008857	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
349163008858	ring oligomerisation interface [polypeptide binding]; other site
349163008859	ATP/Mg binding site [chemical binding]; other site
349163008860	stacking interactions; other site
349163008861	hinge regions; other site
349163008862	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
349163008863	oligomerisation interface [polypeptide binding]; other site
349163008864	mobile loop; other site
349163008865	roof hairpin; other site
349163008866	Usg-like family; Region: Usg; pfam06233
349163008867	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
349163008868	Terminase-like family; Region: Terminase_6; pfam03237
349163008869	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
349163008870	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
349163008871	Protein of unknown function (DUF4043); Region: DUF4043; pfam13252
349163008872	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
349163008873	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
349163008874	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
349163008875	Baseplate J-like protein; Region: Baseplate_J; cl01294
349163008876	Baseplate J-like protein; Region: Baseplate_J; pfam04865
349163008877	Right handed beta helix region; Region: Beta_helix; pfam13229
349163008878	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
349163008879	polyphosphate kinase; Provisional; Region: PRK05443
349163008880	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
349163008881	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
349163008882	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
349163008883	putative domain interface [polypeptide binding]; other site
349163008884	putative active site [active]
349163008885	catalytic site [active]
349163008886	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
349163008887	putative active site [active]
349163008888	catalytic site [active]
349163008889	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
349163008890	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
349163008891	Domain of unknown function DUF20; Region: UPF0118; pfam01594
349163008892	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
349163008893	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
349163008894	dimerization interface [polypeptide binding]; other site
349163008895	putative ATP binding site [chemical binding]; other site
349163008896	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
349163008897	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
349163008898	active site
349163008899	substrate binding site [chemical binding]; other site
349163008900	cosubstrate binding site; other site
349163008901	catalytic site [active]
349163008902	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
349163008903	EamA-like transporter family; Region: EamA; pfam00892
349163008904	EamA-like transporter family; Region: EamA; pfam00892
349163008905	ornithine carbamoyltransferase; Provisional; Region: PRK00779
349163008906	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
349163008907	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
349163008908	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
349163008909	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349163008910	inhibitor-cofactor binding pocket; inhibition site
349163008911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163008912	catalytic residue [active]
349163008913	exopolyphosphatase; Region: exo_poly_only; TIGR03706
349163008914	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
349163008915	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
349163008916	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
349163008917	Uncharacterized conserved protein [Function unknown]; Region: COG2127
349163008918	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
349163008919	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163008920	Walker A motif; other site
349163008921	ATP binding site [chemical binding]; other site
349163008922	Walker B motif; other site
349163008923	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
349163008924	arginine finger; other site
349163008925	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163008926	Walker A motif; other site
349163008927	ATP binding site [chemical binding]; other site
349163008928	Walker B motif; other site
349163008929	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
349163008930	oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154
349163008931	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
349163008932	Cysteine-rich domain; Region: CCG; pfam02754
349163008933	FAD binding domain; Region: FAD_binding_4; pfam01565
349163008934	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
349163008935	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
349163008936	FAD binding domain; Region: FAD_binding_4; pfam01565
349163008937	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
349163008938	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
349163008939	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
349163008940	homodimer interface [polypeptide binding]; other site
349163008941	substrate-cofactor binding pocket; other site
349163008942	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163008943	catalytic residue [active]
349163008944	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
349163008945	putative nucleotide binding site [chemical binding]; other site
349163008946	uridine monophosphate binding site [chemical binding]; other site
349163008947	homohexameric interface [polypeptide binding]; other site
349163008948	ribosome recycling factor; Reviewed; Region: frr; PRK00083
349163008949	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
349163008950	hinge region; other site
349163008951	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
349163008952	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
349163008953	catalytic residue [active]
349163008954	putative FPP diphosphate  binding site; other site
349163008955	putative FPP binding hydrophobic cleft; other site
349163008956	dimer interface [polypeptide binding]; other site
349163008957	putative IPP diphosphate binding site; other site
349163008958	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
349163008959	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
349163008960	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
349163008961	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
349163008962	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
349163008963	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
349163008964	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
349163008965	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
349163008966	active site
349163008967	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
349163008968	protein binding site [polypeptide binding]; other site
349163008969	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
349163008970	putative substrate binding region [chemical binding]; other site
349163008971	ketol-acid reductoisomerase; Provisional; Region: PRK05479
349163008972	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
349163008973	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
349163008974	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
349163008975	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
349163008976	dimer interface [polypeptide binding]; other site
349163008977	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163008978	catalytic residue [active]
349163008979	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
349163008980	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
349163008981	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
349163008982	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349163008983	active site
349163008984	motif I; other site
349163008985	motif II; other site
349163008986	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349163008987	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
349163008988	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
349163008989	nucleotide binding site [chemical binding]; other site
349163008990	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
349163008991	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349163008992	DNA binding residues [nucleotide binding]
349163008993	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
349163008994	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349163008995	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349163008996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163008997	putative PBP binding loops; other site
349163008998	dimer interface [polypeptide binding]; other site
349163008999	ABC-ATPase subunit interface; other site
349163009000	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
349163009001	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
349163009002	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
349163009003	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163009004	Walker A/P-loop; other site
349163009005	ATP binding site [chemical binding]; other site
349163009006	Q-loop/lid; other site
349163009007	ABC transporter signature motif; other site
349163009008	Walker B; other site
349163009009	D-loop; other site
349163009010	H-loop/switch region; other site
349163009011	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
349163009012	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
349163009013	Walker A/P-loop; other site
349163009014	ATP binding site [chemical binding]; other site
349163009015	Q-loop/lid; other site
349163009016	ABC transporter signature motif; other site
349163009017	Walker B; other site
349163009018	D-loop; other site
349163009019	H-loop/switch region; other site
349163009020	TOBE domain; Region: TOBE_2; pfam08402
349163009021	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
349163009022	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
349163009023	putative N- and C-terminal domain interface [polypeptide binding]; other site
349163009024	putative active site [active]
349163009025	MgATP binding site [chemical binding]; other site
349163009026	catalytic site [active]
349163009027	metal binding site [ion binding]; metal-binding site
349163009028	putative xylulose binding site [chemical binding]; other site
349163009029	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
349163009030	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
349163009031	putative ligand binding site [chemical binding]; other site
349163009032	putative NAD binding site [chemical binding]; other site
349163009033	catalytic site [active]
349163009034	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
349163009035	intersubunit interface [polypeptide binding]; other site
349163009036	active site
349163009037	Zn2+ binding site [ion binding]; other site
349163009038	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
349163009039	Uncharacterized conserved protein [Function unknown]; Region: COG3347
349163009040	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
349163009041	Predicted membrane protein [Function unknown]; Region: COG2860
349163009042	UPF0126 domain; Region: UPF0126; pfam03458
349163009043	UPF0126 domain; Region: UPF0126; pfam03458
349163009044	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349163009045	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349163009046	active site
349163009047	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
349163009048	CoA-transferase family III; Region: CoA_transf_3; pfam02515
349163009049	Uncharacterized conserved protein [Function unknown]; Region: COG3777
349163009050	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
349163009051	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
349163009052	active site 2 [active]
349163009053	active site 1 [active]
349163009054	enoyl-CoA hydratase; Region: PLN02864
349163009055	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
349163009056	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
349163009057	dimer interaction site [polypeptide binding]; other site
349163009058	substrate-binding tunnel; other site
349163009059	active site
349163009060	catalytic site [active]
349163009061	substrate binding site [chemical binding]; other site
349163009062	short chain dehydrogenase; Provisional; Region: PRK07791
349163009063	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163009064	NAD(P) binding site [chemical binding]; other site
349163009065	active site
349163009066	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
349163009067	putative active site [active]
349163009068	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
349163009069	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
349163009070	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163009071	Walker A motif; other site
349163009072	ATP binding site [chemical binding]; other site
349163009073	Walker B motif; other site
349163009074	arginine finger; other site
349163009075	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349163009076	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
349163009077	HAMP domain; Region: HAMP; pfam00672
349163009078	dimerization interface [polypeptide binding]; other site
349163009079	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349163009080	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349163009081	dimer interface [polypeptide binding]; other site
349163009082	putative CheW interface [polypeptide binding]; other site
349163009083	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
349163009084	Strictosidine synthase; Region: Str_synth; pfam03088
349163009085	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163009086	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163009087	TM-ABC transporter signature motif; other site
349163009088	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163009089	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163009090	TM-ABC transporter signature motif; other site
349163009091	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
349163009092	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349163009093	Walker A/P-loop; other site
349163009094	ATP binding site [chemical binding]; other site
349163009095	Q-loop/lid; other site
349163009096	ABC transporter signature motif; other site
349163009097	Walker B; other site
349163009098	D-loop; other site
349163009099	H-loop/switch region; other site
349163009100	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349163009101	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
349163009102	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163009103	putative ligand binding site [chemical binding]; other site
349163009104	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
349163009105	Strictosidine synthase; Region: Str_synth; pfam03088
349163009106	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
349163009107	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
349163009108	active site
349163009109	intersubunit interface [polypeptide binding]; other site
349163009110	catalytic residue [active]
349163009111	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
349163009112	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
349163009113	classical (c) SDRs; Region: SDR_c; cd05233
349163009114	NAD(P) binding site [chemical binding]; other site
349163009115	active site
349163009116	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163009117	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163009118	Walker A/P-loop; other site
349163009119	ATP binding site [chemical binding]; other site
349163009120	Q-loop/lid; other site
349163009121	ABC transporter signature motif; other site
349163009122	Walker B; other site
349163009123	D-loop; other site
349163009124	H-loop/switch region; other site
349163009125	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163009126	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163009127	TM-ABC transporter signature motif; other site
349163009128	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
349163009129	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163009130	putative ligand binding site [chemical binding]; other site
349163009131	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163009132	glucose-1-dehydrogenase; Provisional; Region: PRK08936
349163009133	NAD(P) binding site [chemical binding]; other site
349163009134	active site
349163009135	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
349163009136	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163009137	ligand binding site [chemical binding]; other site
349163009138	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163009139	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163009140	TM-ABC transporter signature motif; other site
349163009141	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163009142	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349163009143	Walker A/P-loop; other site
349163009144	ATP binding site [chemical binding]; other site
349163009145	Q-loop/lid; other site
349163009146	ABC transporter signature motif; other site
349163009147	Walker B; other site
349163009148	D-loop; other site
349163009149	H-loop/switch region; other site
349163009150	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
349163009151	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
349163009152	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
349163009153	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
349163009154	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
349163009155	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
349163009156	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
349163009157	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
349163009158	FAD binding pocket [chemical binding]; other site
349163009159	FAD binding motif [chemical binding]; other site
349163009160	phosphate binding motif [ion binding]; other site
349163009161	beta-alpha-beta structure motif; other site
349163009162	NAD(p) ribose binding residues [chemical binding]; other site
349163009163	NAD binding pocket [chemical binding]; other site
349163009164	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
349163009165	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163009166	catalytic loop [active]
349163009167	iron binding site [ion binding]; other site
349163009168	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
349163009169	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
349163009170	gating phenylalanine in ion channel; other site
349163009171	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
349163009172	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
349163009173	DAK2 domain; Region: Dak2; cl03685
349163009174	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
349163009175	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
349163009176	dimerization domain swap beta strand [polypeptide binding]; other site
349163009177	regulatory protein interface [polypeptide binding]; other site
349163009178	active site
349163009179	regulatory phosphorylation site [posttranslational modification]; other site
349163009180	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
349163009181	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
349163009182	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
349163009183	Hint domain; Region: Hint_2; pfam13403
349163009184	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
349163009185	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
349163009186	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
349163009187	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
349163009188	hypothetical protein; Reviewed; Region: PRK00024
349163009189	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
349163009190	MPN+ (JAMM) motif; other site
349163009191	Zinc-binding site [ion binding]; other site
349163009192	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
349163009193	homotrimer interaction site [polypeptide binding]; other site
349163009194	putative active site [active]
349163009195	Surface antigen [General function prediction only]; Region: COG3942
349163009196	CHAP domain; Region: CHAP; cl17642
349163009197	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
349163009198	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
349163009199	S-adenosylmethionine binding site [chemical binding]; other site
349163009200	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
349163009201	SurA N-terminal domain; Region: SurA_N; pfam09312
349163009202	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
349163009203	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
349163009204	OstA-like protein; Region: OstA; cl00844
349163009205	Organic solvent tolerance protein; Region: OstA_C; pfam04453
349163009206	Predicted permeases [General function prediction only]; Region: COG0795
349163009207	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
349163009208	Predicted permeases [General function prediction only]; Region: COG0795
349163009209	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
349163009210	pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265
349163009211	active site
349163009212	hydrophilic channel; other site
349163009213	dimerization interface [polypeptide binding]; other site
349163009214	catalytic residues [active]
349163009215	active site lid [active]
349163009216	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
349163009217	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
349163009218	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
349163009219	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
349163009220	putative dimer interface [polypeptide binding]; other site
349163009221	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
349163009222	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349163009223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163009224	S-adenosylmethionine binding site [chemical binding]; other site
349163009225	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
349163009226	endonuclease III; Region: ENDO3c; smart00478
349163009227	minor groove reading motif; other site
349163009228	helix-hairpin-helix signature motif; other site
349163009229	substrate binding pocket [chemical binding]; other site
349163009230	active site
349163009231	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
349163009232	DEAD-like helicases superfamily; Region: DEXDc; smart00487
349163009233	ATP binding site [chemical binding]; other site
349163009234	Mg++ binding site [ion binding]; other site
349163009235	motif III; other site
349163009236	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349163009237	nucleotide binding region [chemical binding]; other site
349163009238	ATP-binding site [chemical binding]; other site
349163009239	GAF domain; Region: GAF; pfam01590
349163009240	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163009241	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
349163009242	Walker A motif; other site
349163009243	ATP binding site [chemical binding]; other site
349163009244	Walker B motif; other site
349163009245	arginine finger; other site
349163009246	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
349163009247	DNA-binding interface [nucleotide binding]; DNA binding site
349163009248	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
349163009249	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
349163009250	NAD binding site [chemical binding]; other site
349163009251	substrate binding site [chemical binding]; other site
349163009252	catalytic Zn binding site [ion binding]; other site
349163009253	structural Zn binding site [ion binding]; other site
349163009254	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
349163009255	active site
349163009256	Domain of unknown function DUF59; Region: DUF59; pfam01883
349163009257	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
349163009258	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
349163009259	4Fe-4S binding domain; Region: Fer4; cl02805
349163009260	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
349163009261	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349163009262	molybdopterin cofactor binding site; other site
349163009263	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349163009264	The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783
349163009265	putative molybdopterin cofactor binding site; other site
349163009266	tyrosine decarboxylase; Region: PLN02880
349163009267	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349163009268	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349163009269	catalytic residue [active]
349163009270	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
349163009271	Protein export membrane protein; Region: SecD_SecF; cl14618
349163009272	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349163009273	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349163009274	HlyD family secretion protein; Region: HlyD_3; pfam13437
349163009275	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
349163009276	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
349163009277	ligand binding site [chemical binding]; other site
349163009278	NAD binding site [chemical binding]; other site
349163009279	dimerization interface [polypeptide binding]; other site
349163009280	catalytic site [active]
349163009281	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
349163009282	putative L-serine binding site [chemical binding]; other site
349163009283	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
349163009284	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349163009285	catalytic residue [active]
349163009286	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
349163009287	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349163009288	RNA binding surface [nucleotide binding]; other site
349163009289	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
349163009290	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349163009291	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163009292	non-specific DNA binding site [nucleotide binding]; other site
349163009293	salt bridge; other site
349163009294	sequence-specific DNA binding site [nucleotide binding]; other site
349163009295	NusB family; Region: NusB; pfam01029
349163009296	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
349163009297	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
349163009298	YGGT family; Region: YGGT; pfam02325
349163009299	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
349163009300	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
349163009301	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
349163009302	homodimer interface [polypeptide binding]; other site
349163009303	NADP binding site [chemical binding]; other site
349163009304	substrate binding site [chemical binding]; other site
349163009305	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
349163009306	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349163009307	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349163009308	catalytic residue [active]
349163009309	Sporulation related domain; Region: SPOR; pfam05036
349163009310	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349163009311	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349163009312	active site
349163009313	catalytic tetrad [active]
349163009314	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
349163009315	GTP cyclohydrolase I; Provisional; Region: PLN03044
349163009316	active site
349163009317	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
349163009318	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349163009319	TPR repeat; Region: TPR_11; pfam13414
349163009320	binding surface
349163009321	TPR motif; other site
349163009322	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349163009323	binding surface
349163009324	TPR motif; other site
349163009325	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
349163009326	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
349163009327	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
349163009328	putative active site [active]
349163009329	catalytic triad [active]
349163009330	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
349163009331	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
349163009332	dimerization interface [polypeptide binding]; other site
349163009333	ATP binding site [chemical binding]; other site
349163009334	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
349163009335	dimerization interface [polypeptide binding]; other site
349163009336	ATP binding site [chemical binding]; other site
349163009337	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
349163009338	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
349163009339	putative GSH binding site [chemical binding]; other site
349163009340	catalytic residues [active]
349163009341	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
349163009342	pyruvate carboxylase; Reviewed; Region: PRK12999
349163009343	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349163009344	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349163009345	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
349163009346	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
349163009347	active site
349163009348	catalytic residues [active]
349163009349	metal binding site [ion binding]; metal-binding site
349163009350	homodimer binding site [polypeptide binding]; other site
349163009351	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
349163009352	carboxyltransferase (CT) interaction site; other site
349163009353	biotinylation site [posttranslational modification]; other site
349163009354	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
349163009355	MarC family integral membrane protein; Region: MarC; pfam01914
349163009356	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
349163009357	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349163009358	active site
349163009359	HIGH motif; other site
349163009360	nucleotide binding site [chemical binding]; other site
349163009361	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
349163009362	active site
349163009363	KMSKS motif; other site
349163009364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163009365	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349163009366	putative substrate translocation pore; other site
349163009367	manganese transport regulator MntR; Provisional; Region: PRK11050
349163009368	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
349163009369	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
349163009370	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
349163009371	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
349163009372	ATP12 chaperone protein; Region: ATP12; pfam07542
349163009373	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
349163009374	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
349163009375	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
349163009376	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910
349163009377	putative active site [active]
349163009378	Zn binding site [ion binding]; other site
349163009379	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
349163009380	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
349163009381	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
349163009382	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
349163009383	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
349163009384	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349163009385	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
349163009386	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
349163009387	RNA binding site [nucleotide binding]; other site
349163009388	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
349163009389	Maf-like protein; Region: Maf; pfam02545
349163009390	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
349163009391	active site
349163009392	dimer interface [polypeptide binding]; other site
349163009393	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
349163009394	rRNA binding site [nucleotide binding]; other site
349163009395	predicted 30S ribosome binding site; other site
349163009396	histidinol dehydrogenase; Region: hisD; TIGR00069
349163009397	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
349163009398	NAD binding site [chemical binding]; other site
349163009399	dimerization interface [polypeptide binding]; other site
349163009400	product binding site; other site
349163009401	substrate binding site [chemical binding]; other site
349163009402	zinc binding site [ion binding]; other site
349163009403	catalytic residues [active]
349163009404	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
349163009405	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
349163009406	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
349163009407	active site
349163009408	catalytic residues [active]
349163009409	metal binding site [ion binding]; metal-binding site
349163009410	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
349163009411	CoA-transferase family III; Region: CoA_transf_3; pfam02515
349163009412	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
349163009413	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
349163009414	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
349163009415	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
349163009416	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349163009417	FeS/SAM binding site; other site
349163009418	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163009419	NAD(P) binding site [chemical binding]; other site
349163009420	active site
349163009421	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
349163009422	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
349163009423	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
349163009424	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
349163009425	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349163009426	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349163009427	dimer interface [polypeptide binding]; other site
349163009428	putative CheW interface [polypeptide binding]; other site
349163009429	STAS domain; Region: STAS_2; pfam13466
349163009430	Response regulator receiver domain; Region: Response_reg; pfam00072
349163009431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163009432	active site
349163009433	phosphorylation site [posttranslational modification]
349163009434	intermolecular recognition site; other site
349163009435	dimerization interface [polypeptide binding]; other site
349163009436	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
349163009437	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349163009438	putative binding surface; other site
349163009439	active site
349163009440	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
349163009441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163009442	ATP binding site [chemical binding]; other site
349163009443	Mg2+ binding site [ion binding]; other site
349163009444	G-X-G motif; other site
349163009445	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
349163009446	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
349163009447	putative CheA interaction surface; other site
349163009448	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
349163009449	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
349163009450	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
349163009451	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
349163009452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163009453	active site
349163009454	phosphorylation site [posttranslational modification]
349163009455	intermolecular recognition site; other site
349163009456	dimerization interface [polypeptide binding]; other site
349163009457	CheB methylesterase; Region: CheB_methylest; pfam01339
349163009458	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
349163009459	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163009460	active site
349163009461	phosphorylation site [posttranslational modification]
349163009462	intermolecular recognition site; other site
349163009463	dimerization interface [polypeptide binding]; other site
349163009464	CheD chemotactic sensory transduction; Region: CheD; cl00810
349163009465	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
349163009466	SnoaL-like domain; Region: SnoaL_2; pfam12680
349163009467	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349163009468	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
349163009469	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
349163009470	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349163009471	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349163009472	DNA binding residues [nucleotide binding]
349163009473	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
349163009474	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349163009475	RNA binding surface [nucleotide binding]; other site
349163009476	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
349163009477	active site
349163009478	tricarballylate dehydrogenase; Validated; Region: PRK08274
349163009479	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349163009480	tricarballylate utilization protein B; Provisional; Region: PRK15033
349163009481	metabolite-proton symporter; Region: 2A0106; TIGR00883
349163009482	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163009483	putative substrate translocation pore; other site
349163009484	allophanate hydrolase; Provisional; Region: PRK08186
349163009485	Amidase; Region: Amidase; cl11426
349163009486	urea carboxylase; Region: urea_carbox; TIGR02712
349163009487	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349163009488	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349163009489	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
349163009490	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
349163009491	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
349163009492	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
349163009493	carboxyltransferase (CT) interaction site; other site
349163009494	biotinylation site [posttranslational modification]; other site
349163009495	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
349163009496	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
349163009497	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
349163009498	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
349163009499	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
349163009500	Walker A/P-loop; other site
349163009501	ATP binding site [chemical binding]; other site
349163009502	Q-loop/lid; other site
349163009503	ABC transporter signature motif; other site
349163009504	Walker B; other site
349163009505	D-loop; other site
349163009506	H-loop/switch region; other site
349163009507	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
349163009508	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163009509	dimer interface [polypeptide binding]; other site
349163009510	conserved gate region; other site
349163009511	putative PBP binding loops; other site
349163009512	ABC-ATPase subunit interface; other site
349163009513	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
349163009514	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
349163009515	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
349163009516	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
349163009517	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
349163009518	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
349163009519	inhibitor site; inhibition site
349163009520	active site
349163009521	dimer interface [polypeptide binding]; other site
349163009522	catalytic residue [active]
349163009523	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
349163009524	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
349163009525	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
349163009526	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
349163009527	catalytic residue [active]
349163009528	putative FPP diphosphate  binding site; other site
349163009529	putative FPP binding hydrophobic cleft; other site
349163009530	dimer interface [polypeptide binding]; other site
349163009531	putative IPP diphosphate binding site; other site
349163009532	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
349163009533	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163009534	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
349163009535	dimerization interface [polypeptide binding]; other site
349163009536	substrate binding pocket [chemical binding]; other site
349163009537	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349163009538	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349163009539	substrate binding pocket [chemical binding]; other site
349163009540	membrane-bound complex binding site; other site
349163009541	hinge residues; other site
349163009542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163009543	dimer interface [polypeptide binding]; other site
349163009544	conserved gate region; other site
349163009545	putative PBP binding loops; other site
349163009546	ABC-ATPase subunit interface; other site
349163009547	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
349163009548	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163009549	Walker A/P-loop; other site
349163009550	ATP binding site [chemical binding]; other site
349163009551	Q-loop/lid; other site
349163009552	ABC transporter signature motif; other site
349163009553	Walker B; other site
349163009554	D-loop; other site
349163009555	H-loop/switch region; other site
349163009556	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
349163009557	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
349163009558	tetramer interface [polypeptide binding]; other site
349163009559	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349163009560	active site
349163009561	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
349163009562	dimer interface [polypeptide binding]; other site
349163009563	putative tRNA-binding site [nucleotide binding]; other site
349163009564	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
349163009565	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
349163009566	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
349163009567	elongation factor G; Reviewed; Region: PRK12740
349163009568	G1 box; other site
349163009569	GTP/Mg2+ binding site [chemical binding]; other site
349163009570	G3 box; other site
349163009571	Switch II region; other site
349163009572	G4 box; other site
349163009573	G5 box; other site
349163009574	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
349163009575	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
349163009576	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
349163009577	enoyl-CoA hydratase; Validated; Region: PRK08139
349163009578	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349163009579	substrate binding site [chemical binding]; other site
349163009580	oxyanion hole (OAH) forming residues; other site
349163009581	trimer interface [polypeptide binding]; other site
349163009582	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
349163009583	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
349163009584	NAD(P) binding site [chemical binding]; other site
349163009585	homotetramer interface [polypeptide binding]; other site
349163009586	homodimer interface [polypeptide binding]; other site
349163009587	active site
349163009588	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
349163009589	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349163009590	OsmC-like protein; Region: OsmC; cl00767
349163009591	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
349163009592	active site
349163009593	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
349163009594	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
349163009595	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
349163009596	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
349163009597	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
349163009598	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
349163009599	CoA-binding site [chemical binding]; other site
349163009600	ATP-binding [chemical binding]; other site
349163009601	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
349163009602	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
349163009603	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
349163009604	shikimate binding site; other site
349163009605	NAD(P) binding site [chemical binding]; other site
349163009606	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163009607	NAD(P) binding site [chemical binding]; other site
349163009608	active site
349163009609	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
349163009610	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
349163009611	putative catalytic residue [active]
349163009612	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
349163009613	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
349163009614	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
349163009615	putative active site [active]
349163009616	putative substrate binding site [chemical binding]; other site
349163009617	putative cosubstrate binding site; other site
349163009618	catalytic site [active]
349163009619	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
349163009620	active site
349163009621	catalytic site [active]
349163009622	substrate binding site [chemical binding]; other site
349163009623	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
349163009624	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349163009625	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
349163009626	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
349163009627	Potassium binding sites [ion binding]; other site
349163009628	Cesium cation binding sites [ion binding]; other site
349163009629	seryl-tRNA synthetase; Provisional; Region: PRK05431
349163009630	agmatinase; Region: agmatinase; TIGR01230
349163009631	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
349163009632	oligomer interface [polypeptide binding]; other site
349163009633	putative active site [active]
349163009634	Mn binding site [ion binding]; other site
349163009635	amidase; Provisional; Region: PRK07056
349163009636	Amidase; Region: Amidase; cl11426
349163009637	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
349163009638	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
349163009639	Lysine efflux permease [General function prediction only]; Region: COG1279
349163009640	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
349163009641	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163009642	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349163009643	dimerization interface [polypeptide binding]; other site
349163009644	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
349163009645	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349163009646	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349163009647	active site
349163009648	catalytic tetrad [active]
349163009649	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163009650	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163009651	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
349163009652	putative effector binding pocket; other site
349163009653	putative dimerization interface [polypeptide binding]; other site
349163009654	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
349163009655	3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129
349163009656	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
349163009657	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
349163009658	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
349163009659	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163009660	putative ligand binding site [chemical binding]; other site
349163009661	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
349163009662	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349163009663	Walker A/P-loop; other site
349163009664	ATP binding site [chemical binding]; other site
349163009665	Q-loop/lid; other site
349163009666	ABC transporter signature motif; other site
349163009667	Walker B; other site
349163009668	D-loop; other site
349163009669	H-loop/switch region; other site
349163009670	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349163009671	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163009672	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163009673	TM-ABC transporter signature motif; other site
349163009674	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163009675	TM-ABC transporter signature motif; other site
349163009676	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
349163009677	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
349163009678	GDP-binding site [chemical binding]; other site
349163009679	ACT binding site; other site
349163009680	IMP binding site; other site
349163009681	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
349163009682	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
349163009683	motif 1; other site
349163009684	dimer interface [polypeptide binding]; other site
349163009685	active site
349163009686	motif 2; other site
349163009687	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
349163009688	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
349163009689	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
349163009690	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
349163009691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163009692	Walker A motif; other site
349163009693	ATP binding site [chemical binding]; other site
349163009694	Walker B motif; other site
349163009695	arginine finger; other site
349163009696	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349163009697	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
349163009698	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
349163009699	Trp docking motif [polypeptide binding]; other site
349163009700	dimer interface [polypeptide binding]; other site
349163009701	active site
349163009702	small subunit binding site [polypeptide binding]; other site
349163009703	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
349163009704	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349163009705	substrate binding pocket [chemical binding]; other site
349163009706	membrane-bound complex binding site; other site
349163009707	hinge residues; other site
349163009708	Cytochrome c; Region: Cytochrom_C; cl11414
349163009709	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
349163009710	glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417
349163009711	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
349163009712	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
349163009713	substrate binding site [chemical binding]; other site
349163009714	catalytic Zn binding site [ion binding]; other site
349163009715	NAD binding site [chemical binding]; other site
349163009716	structural Zn binding site [ion binding]; other site
349163009717	dimer interface [polypeptide binding]; other site
349163009718	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
349163009719	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349163009720	N-terminal plug; other site
349163009721	ligand-binding site [chemical binding]; other site
349163009722	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
349163009723	FAD binding domain; Region: FAD_binding_4; pfam01565
349163009724	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
349163009725	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
349163009726	Trp docking motif [polypeptide binding]; other site
349163009727	active site
349163009728	Cytochrome c; Region: Cytochrom_C; pfam00034
349163009729	sulfite reductase subunit beta; Provisional; Region: PRK13504
349163009730	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
349163009731	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
349163009732	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
349163009733	Active Sites [active]
349163009734	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
349163009735	Flavodoxin; Region: Flavodoxin_1; pfam00258
349163009736	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
349163009737	FAD binding pocket [chemical binding]; other site
349163009738	FAD binding motif [chemical binding]; other site
349163009739	catalytic residues [active]
349163009740	NAD binding pocket [chemical binding]; other site
349163009741	phosphate binding motif [ion binding]; other site
349163009742	beta-alpha-beta structure motif; other site
349163009743	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
349163009744	active site
349163009745	SAM binding site [chemical binding]; other site
349163009746	homodimer interface [polypeptide binding]; other site
349163009747	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
349163009748	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349163009749	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349163009750	putative DNA binding site [nucleotide binding]; other site
349163009751	putative Zn2+ binding site [ion binding]; other site
349163009752	AsnC family; Region: AsnC_trans_reg; pfam01037
349163009753	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
349163009754	MPT binding site; other site
349163009755	trimer interface [polypeptide binding]; other site
349163009756	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
349163009757	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
349163009758	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163009759	S-adenosylmethionine binding site [chemical binding]; other site
349163009760	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163009761	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349163009762	putative DNA binding site [nucleotide binding]; other site
349163009763	putative Zn2+ binding site [ion binding]; other site
349163009764	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
349163009765	ArsC family; Region: ArsC; pfam03960
349163009766	catalytic residues [active]
349163009767	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
349163009768	arsenical pump membrane protein; Provisional; Region: PRK15445
349163009769	transmembrane helices; other site
349163009770	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349163009771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163009772	active site
349163009773	phosphorylation site [posttranslational modification]
349163009774	intermolecular recognition site; other site
349163009775	dimerization interface [polypeptide binding]; other site
349163009776	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163009777	DNA binding site [nucleotide binding]
349163009778	GTP cyclohydrolase; Provisional; Region: PRK08815
349163009779	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
349163009780	dimerization interface [polypeptide binding]; other site
349163009781	active site
349163009782	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
349163009783	Septum formation initiator; Region: DivIC; cl17659
349163009784	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
349163009785	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
349163009786	tetramer interface [polypeptide binding]; other site
349163009787	TPP-binding site [chemical binding]; other site
349163009788	heterodimer interface [polypeptide binding]; other site
349163009789	phosphorylation loop region [posttranslational modification]
349163009790	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
349163009791	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
349163009792	E3 interaction surface; other site
349163009793	lipoyl attachment site [posttranslational modification]; other site
349163009794	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
349163009795	alpha subunit interface [polypeptide binding]; other site
349163009796	TPP binding site [chemical binding]; other site
349163009797	heterodimer interface [polypeptide binding]; other site
349163009798	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
349163009799	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
349163009800	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
349163009801	E3 interaction surface; other site
349163009802	lipoyl attachment site [posttranslational modification]; other site
349163009803	e3 binding domain; Region: E3_binding; pfam02817
349163009804	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
349163009805	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349163009806	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
349163009807	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349163009808	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349163009809	lipoyl synthase; Provisional; Region: PRK05481
349163009810	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
349163009811	putative coenzyme Q binding site [chemical binding]; other site
349163009812	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349163009813	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
349163009814	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349163009815	catalytic residue [active]
349163009816	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
349163009817	Predicted flavoprotein [General function prediction only]; Region: COG0431
349163009818	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349163009819	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349163009820	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349163009821	active site
349163009822	catalytic tetrad [active]
349163009823	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163009824	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163009825	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
349163009826	putative dimerization interface [polypeptide binding]; other site
349163009827	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
349163009828	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
349163009829	putative valine binding site [chemical binding]; other site
349163009830	dimer interface [polypeptide binding]; other site
349163009831	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
349163009832	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
349163009833	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
349163009834	PYR/PP interface [polypeptide binding]; other site
349163009835	dimer interface [polypeptide binding]; other site
349163009836	TPP binding site [chemical binding]; other site
349163009837	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349163009838	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
349163009839	TPP-binding site [chemical binding]; other site
349163009840	dimer interface [polypeptide binding]; other site
349163009841	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639
349163009842	IPP transferase; Region: IPPT; pfam01715
349163009843	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
349163009844	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349163009845	motif II; other site
349163009846	CoA binding domain; Region: CoA_binding; cl17356
349163009847	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
349163009848	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
349163009849	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
349163009850	Phasin protein; Region: Phasin_2; pfam09361
349163009851	Uncharacterized conserved protein [Function unknown]; Region: COG2127
349163009852	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349163009853	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349163009854	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
349163009855	DNA-binding site [nucleotide binding]; DNA binding site
349163009856	RNA-binding motif; other site
349163009857	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
349163009858	DNA polymerase IV; Provisional; Region: PRK02794
349163009859	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
349163009860	active site
349163009861	DNA binding site [nucleotide binding]
349163009862	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
349163009863	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
349163009864	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
349163009865	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
349163009866	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
349163009867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349163009868	PGAP1-like protein; Region: PGAP1; pfam07819
349163009869	acyl-CoA esterase; Provisional; Region: PRK10673
349163009870	EVE domain; Region: EVE; pfam01878
349163009871	YCII-related domain; Region: YCII; cl00999
349163009872	heme exporter protein CcmC; Region: ccmC; TIGR01191
349163009873	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
349163009874	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
349163009875	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349163009876	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349163009877	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
349163009878	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
349163009879	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
349163009880	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
349163009881	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
349163009882	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
349163009883	Cl- selectivity filter; other site
349163009884	Cl- binding residues [ion binding]; other site
349163009885	pore gating glutamate residue; other site
349163009886	dimer interface [polypeptide binding]; other site
349163009887	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
349163009888	hypothetical protein; Validated; Region: PRK07586
349163009889	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
349163009890	PYR/PP interface [polypeptide binding]; other site
349163009891	dimer interface [polypeptide binding]; other site
349163009892	TPP binding site [chemical binding]; other site
349163009893	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
349163009894	TPP-binding site [chemical binding]; other site
349163009895	dimer interface [polypeptide binding]; other site
349163009896	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349163009897	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349163009898	ligand binding site [chemical binding]; other site
349163009899	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
349163009900	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349163009901	ATP binding site [chemical binding]; other site
349163009902	putative Mg++ binding site [ion binding]; other site
349163009903	helicase superfamily c-terminal domain; Region: HELICc; smart00490
349163009904	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
349163009905	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
349163009906	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
349163009907	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
349163009908	DsbD alpha interface [polypeptide binding]; other site
349163009909	catalytic residues [active]
349163009910	Cytochrome c; Region: Cytochrom_C; cl11414
349163009911	Cytochrome c; Region: Cytochrom_C; cl11414
349163009912	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
349163009913	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
349163009914	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
349163009915	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
349163009916	NAD(P) binding site [chemical binding]; other site
349163009917	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
349163009918	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163009919	Walker A/P-loop; other site
349163009920	ATP binding site [chemical binding]; other site
349163009921	Q-loop/lid; other site
349163009922	ABC transporter signature motif; other site
349163009923	Walker B; other site
349163009924	D-loop; other site
349163009925	H-loop/switch region; other site
349163009926	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
349163009927	Permease; Region: Permease; pfam02405
349163009928	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
349163009929	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
349163009930	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349163009931	catalytic residue [active]
349163009932	EcsC protein family; Region: EcsC; pfam12787
349163009933	replicative DNA helicase; Provisional; Region: PRK09165
349163009934	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
349163009935	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
349163009936	Walker A motif; other site
349163009937	ATP binding site [chemical binding]; other site
349163009938	Walker B motif; other site
349163009939	DNA binding loops [nucleotide binding]
349163009940	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
349163009941	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
349163009942	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349163009943	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
349163009944	substrate binding site [chemical binding]; other site
349163009945	dimer interface [polypeptide binding]; other site
349163009946	ATP binding site [chemical binding]; other site
349163009947	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
349163009948	FOG: CBS domain [General function prediction only]; Region: COG0517
349163009949	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
349163009950	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
349163009951	substrate binding site [chemical binding]; other site
349163009952	ATP binding site [chemical binding]; other site
349163009953	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
349163009954	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
349163009955	active site
349163009956	FMN binding site [chemical binding]; other site
349163009957	substrate binding site [chemical binding]; other site
349163009958	homotetramer interface [polypeptide binding]; other site
349163009959	catalytic residue [active]
349163009960	LexA repressor; Validated; Region: PRK00215
349163009961	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
349163009962	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
349163009963	Catalytic site [active]
349163009964	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
349163009965	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
349163009966	putative metal binding site [ion binding]; other site
349163009967	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349163009968	HSP70 interaction site [polypeptide binding]; other site
349163009969	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
349163009970	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
349163009971	amidase catalytic site [active]
349163009972	Zn binding residues [ion binding]; other site
349163009973	substrate binding site [chemical binding]; other site
349163009974	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
349163009975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163009976	ATP binding site [chemical binding]; other site
349163009977	Mg2+ binding site [ion binding]; other site
349163009978	G-X-G motif; other site
349163009979	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
349163009980	anchoring element; other site
349163009981	dimer interface [polypeptide binding]; other site
349163009982	ATP binding site [chemical binding]; other site
349163009983	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
349163009984	active site
349163009985	putative metal-binding site [ion binding]; other site
349163009986	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
349163009987	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
349163009988	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163009989	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
349163009990	dimerization interface [polypeptide binding]; other site
349163009991	substrate binding pocket [chemical binding]; other site
349163009992	Predicted permeases [General function prediction only]; Region: COG0679
349163009993	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349163009994	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349163009995	metal binding site [ion binding]; metal-binding site
349163009996	active site
349163009997	I-site; other site
349163009998	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349163009999	Uncharacterized conserved protein [Function unknown]; Region: COG3791
349163010000	Putative cyclase; Region: Cyclase; cl00814
349163010001	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349163010002	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349163010003	non-specific DNA binding site [nucleotide binding]; other site
349163010004	salt bridge; other site
349163010005	sequence-specific DNA binding site [nucleotide binding]; other site
349163010006	Smr domain; Region: Smr; pfam01713
349163010007	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
349163010008	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
349163010009	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
349163010010	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349163010011	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
349163010012	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
349163010013	translocation protein TolB; Provisional; Region: tolB; PRK05137
349163010014	TolB amino-terminal domain; Region: TolB_N; pfam04052
349163010015	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
349163010016	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
349163010017	TolR protein; Region: tolR; TIGR02801
349163010018	TolQ protein; Region: tolQ; TIGR02796
349163010019	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
349163010020	active site
349163010021	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
349163010022	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163010023	Walker A motif; other site
349163010024	ATP binding site [chemical binding]; other site
349163010025	Walker B motif; other site
349163010026	arginine finger; other site
349163010027	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
349163010028	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
349163010029	RuvA N terminal domain; Region: RuvA_N; pfam01330
349163010030	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
349163010031	active site
349163010032	putative DNA-binding cleft [nucleotide binding]; other site
349163010033	dimer interface [polypeptide binding]; other site
349163010034	hypothetical protein; Validated; Region: PRK00110
349163010035	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163010036	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163010037	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163010038	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163010039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163010040	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349163010041	putative substrate translocation pore; other site
349163010042	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
349163010043	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
349163010044	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
349163010045	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
349163010046	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
349163010047	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349163010048	Walker A/P-loop; other site
349163010049	ATP binding site [chemical binding]; other site
349163010050	Q-loop/lid; other site
349163010051	ABC transporter signature motif; other site
349163010052	Walker B; other site
349163010053	D-loop; other site
349163010054	H-loop/switch region; other site
349163010055	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349163010056	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
349163010057	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163010058	Walker A/P-loop; other site
349163010059	ATP binding site [chemical binding]; other site
349163010060	Q-loop/lid; other site
349163010061	ABC transporter signature motif; other site
349163010062	Walker B; other site
349163010063	D-loop; other site
349163010064	H-loop/switch region; other site
349163010065	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
349163010066	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
349163010067	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
349163010068	active site
349163010069	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
349163010070	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
349163010071	active site
349163010072	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
349163010073	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349163010074	DNA-binding site [nucleotide binding]; DNA binding site
349163010075	UTRA domain; Region: UTRA; pfam07702
349163010076	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349163010077	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349163010078	active site
349163010079	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
349163010080	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
349163010081	Probable Catalytic site; other site
349163010082	metal-binding site
349163010083	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
349163010084	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
349163010085	23S rRNA binding site [nucleotide binding]; other site
349163010086	L21 binding site [polypeptide binding]; other site
349163010087	L13 binding site [polypeptide binding]; other site
349163010088	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
349163010089	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
349163010090	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349163010091	putative active site [active]
349163010092	putative metal binding site [ion binding]; other site
349163010093	conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096
349163010094	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
349163010095	Prostaglandin dehydrogenases; Region: PGDH; cd05288
349163010096	NAD(P) binding site [chemical binding]; other site
349163010097	substrate binding site [chemical binding]; other site
349163010098	dimer interface [polypeptide binding]; other site
349163010099	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163010100	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
349163010101	Walker A/P-loop; other site
349163010102	ATP binding site [chemical binding]; other site
349163010103	Q-loop/lid; other site
349163010104	ABC transporter signature motif; other site
349163010105	Walker B; other site
349163010106	D-loop; other site
349163010107	H-loop/switch region; other site
349163010108	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
349163010109	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
349163010110	Walker A/P-loop; other site
349163010111	ATP binding site [chemical binding]; other site
349163010112	Q-loop/lid; other site
349163010113	ABC transporter signature motif; other site
349163010114	Walker B; other site
349163010115	D-loop; other site
349163010116	H-loop/switch region; other site
349163010117	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349163010118	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
349163010119	putative ligand binding site [chemical binding]; other site
349163010120	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
349163010121	TM-ABC transporter signature motif; other site
349163010122	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
349163010123	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
349163010124	TM-ABC transporter signature motif; other site
349163010125	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
349163010126	Amidase; Region: Amidase; cl11426
349163010127	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
349163010128	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
349163010129	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
349163010130	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
349163010131	active site
349163010132	homodimer interface [polypeptide binding]; other site
349163010133	catalytic site [active]
349163010134	acceptor binding site [chemical binding]; other site
349163010135	trehalose synthase; Region: treS_nterm; TIGR02456
349163010136	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
349163010137	active site
349163010138	catalytic site [active]
349163010139	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
349163010140	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
349163010141	glycogen branching enzyme; Provisional; Region: PRK05402
349163010142	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
349163010143	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
349163010144	active site
349163010145	catalytic site [active]
349163010146	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
349163010147	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
349163010148	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
349163010149	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
349163010150	active site
349163010151	catalytic site [active]
349163010152	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
349163010153	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
349163010154	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
349163010155	Ligand binding site; other site
349163010156	Putative Catalytic site; other site
349163010157	DXD motif; other site
349163010158	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
349163010159	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163010160	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163010161	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349163010162	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
349163010163	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163010164	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
349163010165	AAA ATPase domain; Region: AAA_16; pfam13191
349163010166	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
349163010167	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
349163010168	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
349163010169	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
349163010170	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
349163010171	heme bL binding site [chemical binding]; other site
349163010172	interchain domain interface [polypeptide binding]; other site
349163010173	intrachain domain interface; other site
349163010174	heme bH binding site [chemical binding]; other site
349163010175	Qo binding site; other site
349163010176	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
349163010177	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
349163010178	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
349163010179	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
349163010180	dimer interface [polypeptide binding]; other site
349163010181	decamer (pentamer of dimers) interface [polypeptide binding]; other site
349163010182	catalytic triad [active]
349163010183	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
349163010184	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
349163010185	Walker A/P-loop; other site
349163010186	ATP binding site [chemical binding]; other site
349163010187	Q-loop/lid; other site
349163010188	ABC transporter signature motif; other site
349163010189	Walker B; other site
349163010190	D-loop; other site
349163010191	H-loop/switch region; other site
349163010192	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
349163010193	PhoU domain; Region: PhoU; pfam01895
349163010194	PhoU domain; Region: PhoU; pfam01895
349163010195	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
349163010196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163010197	active site
349163010198	phosphorylation site [posttranslational modification]
349163010199	intermolecular recognition site; other site
349163010200	dimerization interface [polypeptide binding]; other site
349163010201	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349163010202	DNA binding site [nucleotide binding]
349163010203	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
349163010204	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
349163010205	Na binding site [ion binding]; other site
349163010206	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
349163010207	Bacterial sugar transferase; Region: Bac_transf; pfam02397
349163010208	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
349163010209	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
349163010210	Membrane-associated tegument protein; Region: UL11; cl17374
349163010211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163010212	ATP binding site [chemical binding]; other site
349163010213	Mg2+ binding site [ion binding]; other site
349163010214	G-X-G motif; other site
349163010215	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
349163010216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349163010217	active site
349163010218	phosphorylation site [posttranslational modification]
349163010219	intermolecular recognition site; other site
349163010220	dimerization interface [polypeptide binding]; other site
349163010221	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163010222	Walker A motif; other site
349163010223	ATP binding site [chemical binding]; other site
349163010224	Walker B motif; other site
349163010225	arginine finger; other site
349163010226	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
349163010227	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349163010228	binding surface
349163010229	TPR motif; other site
349163010230	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349163010231	binding surface
349163010232	TPR motif; other site
349163010233	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349163010234	TPR motif; other site
349163010235	O-Antigen ligase; Region: Wzy_C; cl04850
349163010236	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
349163010237	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349163010238	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
349163010239	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
349163010240	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
349163010241	Chain length determinant protein; Region: Wzz; cl15801
349163010242	AAA domain; Region: AAA_31; pfam13614
349163010243	uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016
349163010244	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
349163010245	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163010246	Walker A motif; other site
349163010247	ATP binding site [chemical binding]; other site
349163010248	Walker B motif; other site
349163010249	arginine finger; other site
349163010250	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
349163010251	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
349163010252	putative active site [active]
349163010253	putative catalytic site [active]
349163010254	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
349163010255	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
349163010256	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
349163010257	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
349163010258	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
349163010259	Cupin domain; Region: Cupin_2; cl17218
349163010260	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
349163010261	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163010262	Walker A motif; other site
349163010263	ATP binding site [chemical binding]; other site
349163010264	Walker B motif; other site
349163010265	arginine finger; other site
349163010266	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
349163010267	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
349163010268	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
349163010269	NAD(P) binding site [chemical binding]; other site
349163010270	SnoaL-like domain; Region: SnoaL_2; pfam12680
349163010271	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
349163010272	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
349163010273	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
349163010274	TadE-like protein; Region: TadE; pfam07811
349163010275	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
349163010276	Domain of unknown function (DUF718); Region: DUF718; pfam05336
349163010277	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163010278	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163010279	TM-ABC transporter signature motif; other site
349163010280	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163010281	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349163010282	TM-ABC transporter signature motif; other site
349163010283	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
349163010284	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349163010285	Walker A/P-loop; other site
349163010286	ATP binding site [chemical binding]; other site
349163010287	Q-loop/lid; other site
349163010288	ABC transporter signature motif; other site
349163010289	Walker B; other site
349163010290	D-loop; other site
349163010291	H-loop/switch region; other site
349163010292	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349163010293	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
349163010294	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349163010295	ligand binding site [chemical binding]; other site
349163010296	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
349163010297	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
349163010298	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
349163010299	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
349163010300	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
349163010301	short chain dehydrogenase; Validated; Region: PRK08324
349163010302	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
349163010303	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163010304	NAD(P) binding site [chemical binding]; other site
349163010305	active site
349163010306	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
349163010307	N- and C-terminal domain interface [polypeptide binding]; other site
349163010308	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
349163010309	active site
349163010310	putative catalytic site [active]
349163010311	metal binding site [ion binding]; metal-binding site
349163010312	ATP binding site [chemical binding]; other site
349163010313	carbohydrate binding site [chemical binding]; other site
349163010314	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
349163010315	HAMP domain; Region: HAMP; pfam00672
349163010316	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349163010317	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349163010318	dimer interface [polypeptide binding]; other site
349163010319	putative CheW interface [polypeptide binding]; other site
349163010320	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
349163010321	30S subunit binding site; other site
349163010322	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
349163010323	DNA-binding site [nucleotide binding]; DNA binding site
349163010324	RNA-binding motif; other site
349163010325	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
349163010326	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349163010327	HSP70 interaction site [polypeptide binding]; other site
349163010328	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
349163010329	substrate binding site [polypeptide binding]; other site
349163010330	dimer interface [polypeptide binding]; other site
349163010331	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
349163010332	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
349163010333	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
349163010334	Moco binding site; other site
349163010335	metal coordination site [ion binding]; other site
349163010336	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
349163010337	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
349163010338	putative catalytic residues [active]
349163010339	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163010340	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163010341	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
349163010342	dimerization interface [polypeptide binding]; other site
349163010343	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
349163010344	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
349163010345	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
349163010346	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
349163010347	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
349163010348	Walker A/P-loop; other site
349163010349	ATP binding site [chemical binding]; other site
349163010350	Q-loop/lid; other site
349163010351	ABC transporter signature motif; other site
349163010352	Walker B; other site
349163010353	D-loop; other site
349163010354	H-loop/switch region; other site
349163010355	TOBE domain; Region: TOBE_2; pfam08402
349163010356	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
349163010357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163010358	dimer interface [polypeptide binding]; other site
349163010359	conserved gate region; other site
349163010360	putative PBP binding loops; other site
349163010361	ABC-ATPase subunit interface; other site
349163010362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349163010363	dimer interface [polypeptide binding]; other site
349163010364	conserved gate region; other site
349163010365	ABC-ATPase subunit interface; other site
349163010366	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
349163010367	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349163010368	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
349163010369	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
349163010370	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349163010371	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349163010372	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349163010373	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
349163010374	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
349163010375	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349163010376	catalytic loop [active]
349163010377	iron binding site [ion binding]; other site
349163010378	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
349163010379	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
349163010380	MarR family; Region: MarR; pfam01047
349163010381	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349163010382	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349163010383	Coenzyme A binding pocket [chemical binding]; other site
349163010384	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
349163010385	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349163010386	inhibitor-cofactor binding pocket; inhibition site
349163010387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163010388	catalytic residue [active]
349163010389	Ectoine synthase; Region: Ectoine_synth; pfam06339
349163010390	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
349163010391	aspartate kinase; Validated; Region: PRK09181
349163010392	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
349163010393	nucleotide binding site [chemical binding]; other site
349163010394	substrate binding site [chemical binding]; other site
349163010395	ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_1; cd04910
349163010396	allosteric regulatory residue; other site
349163010397	ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_2; cd04915
349163010398	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349163010399	putative substrate translocation pore; other site
349163010400	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
349163010401	mce related protein; Region: MCE; pfam02470
349163010402	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
349163010403	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349163010404	Walker A/P-loop; other site
349163010405	ATP binding site [chemical binding]; other site
349163010406	Q-loop/lid; other site
349163010407	ABC transporter signature motif; other site
349163010408	Walker B; other site
349163010409	D-loop; other site
349163010410	H-loop/switch region; other site
349163010411	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
349163010412	Permease; Region: Permease; pfam02405
349163010413	Integral membrane protein TerC family; Region: TerC; cl10468
349163010414	adenylosuccinate lyase; Provisional; Region: PRK07492
349163010415	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
349163010416	tetramer interface [polypeptide binding]; other site
349163010417	active site
349163010418	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
349163010419	NRDE protein; Region: NRDE; cl01315
349163010420	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
349163010421	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
349163010422	tetrameric interface [polypeptide binding]; other site
349163010423	NAD binding site [chemical binding]; other site
349163010424	catalytic residues [active]
349163010425	allantoate amidohydrolase; Reviewed; Region: PRK12893
349163010426	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
349163010427	active site
349163010428	metal binding site [ion binding]; metal-binding site
349163010429	dimer interface [polypeptide binding]; other site
349163010430	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
349163010431	SnoaL-like domain; Region: SnoaL_2; pfam12680
349163010432	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
349163010433	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349163010434	DsrE/DsrF-like family; Region: DrsE; cl00672
349163010435	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349163010436	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
349163010437	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349163010438	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
349163010439	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349163010440	NAD(P) binding site [chemical binding]; other site
349163010441	active site
349163010442	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
349163010443	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
349163010444	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
349163010445	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
349163010446	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
349163010447	dimer interaction site [polypeptide binding]; other site
349163010448	substrate-binding tunnel; other site
349163010449	active site
349163010450	catalytic site [active]
349163010451	substrate binding site [chemical binding]; other site
349163010452	phosphate acetyltransferase; Provisional; Region: PRK11890
349163010453	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
349163010454	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
349163010455	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
349163010456	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
349163010457	Na binding site [ion binding]; other site
349163010458	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
349163010459	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349163010460	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349163010461	WHG domain; Region: WHG; pfam13305
349163010462	aldolase II superfamily protein; Provisional; Region: PRK07044
349163010463	intersubunit interface [polypeptide binding]; other site
349163010464	active site
349163010465	Zn2+ binding site [ion binding]; other site
349163010466	Phospholipid methyltransferase; Region: PEMT; cl17370
349163010467	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
349163010468	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
349163010469	Moco binding site; other site
349163010470	metal coordination site [ion binding]; other site
349163010471	Cytochrome c; Region: Cytochrom_C; pfam00034
349163010472	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
349163010473	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
349163010474	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
349163010475	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
349163010476	Cytochrome c [Energy production and conversion]; Region: COG3258
349163010477	Cytochrome c [Energy production and conversion]; Region: COG3258
349163010478	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
349163010479	active site
349163010480	metal binding site [ion binding]; metal-binding site
349163010481	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
349163010482	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
349163010483	DsrE/DsrF-like family; Region: DrsE; pfam02635
349163010484	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
349163010485	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
349163010486	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
349163010487	Domain of unknown function DUF302; Region: DUF302; pfam03625
349163010488	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
349163010489	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
349163010490	propionate/acetate kinase; Provisional; Region: PRK12379
349163010491	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
349163010492	cyclase homology domain; Region: CHD; cd07302
349163010493	nucleotidyl binding site; other site
349163010494	metal binding site [ion binding]; metal-binding site
349163010495	dimer interface [polypeptide binding]; other site
349163010496	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
349163010497	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
349163010498	phosphopeptide binding site; other site
349163010499	glutamine synthetase; Provisional; Region: glnA; PRK09469
349163010500	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
349163010501	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
349163010502	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
349163010503	Nitrogen regulatory protein P-II; Region: P-II; smart00938
349163010504	hypothetical protein; Provisional; Region: PRK08912
349163010505	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349163010506	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349163010507	homodimer interface [polypeptide binding]; other site
349163010508	catalytic residue [active]
349163010509	nitrilase; Region: PLN02798
349163010510	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
349163010511	putative active site [active]
349163010512	catalytic triad [active]
349163010513	dimer interface [polypeptide binding]; other site
349163010514	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
349163010515	ATP-NAD kinase; Region: NAD_kinase; pfam01513
349163010516	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
349163010517	malate dehydrogenase; Provisional; Region: PRK05442
349163010518	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
349163010519	NAD(P) binding site [chemical binding]; other site
349163010520	dimer interface [polypeptide binding]; other site
349163010521	malate binding site [chemical binding]; other site
349163010522	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349163010523	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349163010524	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349163010525	putative effector binding pocket; other site
349163010526	dimerization interface [polypeptide binding]; other site
349163010527	Protein of unknown function (DUF796); Region: DUF796; pfam05638
349163010528	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
349163010529	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163010530	Walker A motif; other site
349163010531	ATP binding site [chemical binding]; other site
349163010532	Walker B motif; other site
349163010533	arginine finger; other site
349163010534	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349163010535	Walker A motif; other site
349163010536	ATP binding site [chemical binding]; other site
349163010537	Walker B motif; other site
349163010538	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
349163010539	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
349163010540	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
349163010541	Protein of unknown function (DUF877); Region: DUF877; pfam05943
349163010542	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
349163010543	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
349163010544	Protein of unknown function (DUF877); Region: DUF877; pfam05943
349163010545	Protein of unknown function (DUF770); Region: DUF770; pfam05591
349163010546	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
349163010547	Cytomegalovirus UL84 protein; Region: Cytomega_UL84; pfam06284
349163010548	ImpE protein; Region: ImpE; pfam07024
349163010549	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
349163010550	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
349163010551	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
349163010552	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
349163010553	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349163010554	S-adenosylmethionine binding site [chemical binding]; other site
349163010555	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
349163010556	cyanophycin synthetase; Provisional; Region: PRK14016
349163010557	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
349163010558	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
349163010559	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
349163010560	putative acyl-acceptor binding pocket; other site
349163010561	Uncharacterized conserved protein [Function unknown]; Region: COG1434
349163010562	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
349163010563	putative active site [active]
349163010564	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
349163010565	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
349163010566	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349163010567	Walker A/P-loop; other site
349163010568	ATP binding site [chemical binding]; other site
349163010569	Q-loop/lid; other site
349163010570	ABC transporter signature motif; other site
349163010571	Walker B; other site
349163010572	D-loop; other site
349163010573	H-loop/switch region; other site
349163010574	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
349163010575	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
349163010576	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
349163010577	active site
349163010578	dimer interface [polypeptide binding]; other site
349163010579	heat shock protein 90; Provisional; Region: PRK05218
349163010580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349163010581	ATP binding site [chemical binding]; other site
349163010582	Mg2+ binding site [ion binding]; other site
349163010583	G-X-G motif; other site
349163010584	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
349163010585	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349163010586	nucleotide binding region [chemical binding]; other site
349163010587	ATP-binding site [chemical binding]; other site
349163010588	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349163010589	RNA binding surface [nucleotide binding]; other site
349163010590	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
349163010591	4Fe-4S binding domain; Region: Fer4; cl02805
349163010592	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
349163010593	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
349163010594	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
349163010595	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
349163010596	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
349163010597	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
349163010598	Walker A/P-loop; other site
349163010599	ATP binding site [chemical binding]; other site
349163010600	Q-loop/lid; other site
349163010601	ABC transporter signature motif; other site
349163010602	Walker B; other site
349163010603	D-loop; other site
349163010604	H-loop/switch region; other site
349163010605	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
349163010606	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
349163010607	TM-ABC transporter signature motif; other site
349163010608	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
349163010609	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
349163010610	Walker A/P-loop; other site
349163010611	ATP binding site [chemical binding]; other site
349163010612	Q-loop/lid; other site
349163010613	ABC transporter signature motif; other site
349163010614	Walker B; other site
349163010615	D-loop; other site
349163010616	H-loop/switch region; other site
349163010617	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349163010618	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
349163010619	TM-ABC transporter signature motif; other site
349163010620	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
349163010621	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
349163010622	dimerization interface [polypeptide binding]; other site
349163010623	ligand binding site [chemical binding]; other site
349163010624	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
349163010625	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349163010626	N-terminal plug; other site
349163010627	ligand-binding site [chemical binding]; other site
349163010628	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
349163010629	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349163010630	motif II; other site
349163010631	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349163010632	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
349163010633	putative C-terminal domain interface [polypeptide binding]; other site
349163010634	putative GSH binding site (G-site) [chemical binding]; other site
349163010635	putative dimer interface [polypeptide binding]; other site
349163010636	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
349163010637	putative dimer interface [polypeptide binding]; other site
349163010638	putative N-terminal domain interface [polypeptide binding]; other site
349163010639	putative substrate binding pocket (H-site) [chemical binding]; other site
349163010640	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349163010641	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
349163010642	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349163010643	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349163010644	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
349163010645	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
349163010646	catalytic residues [active]
349163010647	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
349163010648	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349163010649	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349163010650	catalytic residue [active]
349163010651	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239