-- dump date 20140618_184955 -- class Genbank::misc_feature -- table misc_feature_note -- id note 743299000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 743299000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 743299000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299000004 Walker A motif; other site 743299000005 ATP binding site [chemical binding]; other site 743299000006 Walker B motif; other site 743299000007 arginine finger; other site 743299000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 743299000009 DnaA box-binding interface [nucleotide binding]; other site 743299000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 743299000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 743299000012 putative DNA binding surface [nucleotide binding]; other site 743299000013 dimer interface [polypeptide binding]; other site 743299000014 beta-clamp/clamp loader binding surface; other site 743299000015 beta-clamp/translesion DNA polymerase binding surface; other site 743299000016 recombination protein F; Reviewed; Region: recF; PRK00064 743299000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299000018 Walker A/P-loop; other site 743299000019 ATP binding site [chemical binding]; other site 743299000020 Q-loop/lid; other site 743299000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299000022 ABC transporter signature motif; other site 743299000023 Walker B; other site 743299000024 D-loop; other site 743299000025 H-loop/switch region; other site 743299000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 743299000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299000028 ATP binding site [chemical binding]; other site 743299000029 Mg2+ binding site [ion binding]; other site 743299000030 G-X-G motif; other site 743299000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 743299000032 anchoring element; other site 743299000033 dimer interface [polypeptide binding]; other site 743299000034 ATP binding site [chemical binding]; other site 743299000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 743299000036 active site 743299000037 putative metal-binding site [ion binding]; other site 743299000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 743299000039 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 743299000040 putative active site [active] 743299000041 putative metal binding site [ion binding]; other site 743299000042 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 743299000043 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 743299000044 FAD binding pocket [chemical binding]; other site 743299000045 FAD binding motif [chemical binding]; other site 743299000046 phosphate binding motif [ion binding]; other site 743299000047 beta-alpha-beta structure motif; other site 743299000048 NAD binding pocket [chemical binding]; other site 743299000049 Iron coordination center [ion binding]; other site 743299000050 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 743299000051 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 743299000052 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 743299000053 Switch I; other site 743299000054 Switch II; other site 743299000055 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 743299000056 septum site-determining protein MinC; Region: minC; TIGR01222 743299000057 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 743299000058 Ferredoxin [Energy production and conversion]; Region: COG1146 743299000059 4Fe-4S binding domain; Region: Fer4; pfam00037 743299000060 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 743299000061 DNA topoisomerase I; Validated; Region: PRK06599 743299000062 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 743299000063 active site 743299000064 interdomain interaction site; other site 743299000065 putative metal-binding site [ion binding]; other site 743299000066 nucleotide binding site [chemical binding]; other site 743299000067 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 743299000068 domain I; other site 743299000069 DNA binding groove [nucleotide binding] 743299000070 phosphate binding site [ion binding]; other site 743299000071 domain II; other site 743299000072 domain III; other site 743299000073 nucleotide binding site [chemical binding]; other site 743299000074 catalytic site [active] 743299000075 domain IV; other site 743299000076 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 743299000077 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 743299000078 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 743299000079 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 743299000080 Protein of unknown function (DUF494); Region: DUF494; cl01103 743299000081 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 743299000082 DNA protecting protein DprA; Region: dprA; TIGR00732 743299000083 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 743299000084 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743299000085 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 743299000086 active site 743299000087 catalytic residues [active] 743299000088 metal binding site [ion binding]; metal-binding site 743299000089 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 743299000090 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 743299000091 putative active site [active] 743299000092 substrate binding site [chemical binding]; other site 743299000093 putative cosubstrate binding site; other site 743299000094 catalytic site [active] 743299000095 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 743299000096 substrate binding site [chemical binding]; other site 743299000097 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 743299000098 16S rRNA methyltransferase B; Provisional; Region: PRK10901 743299000099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299000100 S-adenosylmethionine binding site [chemical binding]; other site 743299000101 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 743299000102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743299000103 dimerization interface [polypeptide binding]; other site 743299000104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299000105 dimer interface [polypeptide binding]; other site 743299000106 phosphorylation site [posttranslational modification] 743299000107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299000108 ATP binding site [chemical binding]; other site 743299000109 G-X-G motif; other site 743299000110 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743299000111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299000112 active site 743299000113 phosphorylation site [posttranslational modification] 743299000114 intermolecular recognition site; other site 743299000115 dimerization interface [polypeptide binding]; other site 743299000116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299000117 Walker A motif; other site 743299000118 ATP binding site [chemical binding]; other site 743299000119 Walker B motif; other site 743299000120 arginine finger; other site 743299000121 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 743299000122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743299000123 dimerization interface [polypeptide binding]; other site 743299000124 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743299000125 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743299000126 dimer interface [polypeptide binding]; other site 743299000127 putative CheW interface [polypeptide binding]; other site 743299000128 Putative glucoamylase; Region: Glycoamylase; pfam10091 743299000129 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 743299000130 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 743299000131 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 743299000132 PAS domain S-box; Region: sensory_box; TIGR00229 743299000133 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743299000134 putative active site [active] 743299000135 heme pocket [chemical binding]; other site 743299000136 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743299000137 GAF domain; Region: GAF; pfam01590 743299000138 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299000139 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299000140 metal binding site [ion binding]; metal-binding site 743299000141 active site 743299000142 I-site; other site 743299000143 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299000144 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 743299000145 ArsC family; Region: ArsC; pfam03960 743299000146 putative catalytic residues [active] 743299000147 Uncharacterized conserved protein [Function unknown]; Region: COG1565 743299000148 pteridine reductase; Provisional; Region: PRK09135 743299000149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299000150 NAD(P) binding site [chemical binding]; other site 743299000151 active site 743299000152 NifU-like domain; Region: NifU; cl00484 743299000153 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 743299000154 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 743299000155 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299000156 FeS/SAM binding site; other site 743299000157 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 743299000158 homooctamer interface [polypeptide binding]; other site 743299000159 active site 743299000160 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 743299000161 UGMP family protein; Validated; Region: PRK09604 743299000162 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 743299000163 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 743299000164 dinuclear metal binding motif [ion binding]; other site 743299000165 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 743299000166 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 743299000167 PQQ-like domain; Region: PQQ_2; pfam13360 743299000168 Trp docking motif [polypeptide binding]; other site 743299000169 active site 743299000170 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 743299000171 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 743299000172 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 743299000173 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 743299000174 putative active site [active] 743299000175 homotetrameric interface [polypeptide binding]; other site 743299000176 metal binding site [ion binding]; metal-binding site 743299000177 Protein of unknown function (DUF497); Region: DUF497; pfam04365 743299000178 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 743299000179 nudix motif; other site 743299000180 multidrug efflux protein; Reviewed; Region: PRK09579 743299000181 Protein export membrane protein; Region: SecD_SecF; cl14618 743299000182 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743299000183 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299000184 Outer membrane efflux protein; Region: OEP; pfam02321 743299000185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743299000186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299000187 active site 743299000188 phosphorylation site [posttranslational modification] 743299000189 intermolecular recognition site; other site 743299000190 dimerization interface [polypeptide binding]; other site 743299000191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743299000192 DNA binding site [nucleotide binding] 743299000193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743299000194 dimerization interface [polypeptide binding]; other site 743299000195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299000196 ATP binding site [chemical binding]; other site 743299000197 Mg2+ binding site [ion binding]; other site 743299000198 G-X-G motif; other site 743299000199 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 743299000200 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 743299000201 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 743299000202 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 743299000203 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743299000204 Predicted membrane protein [Function unknown]; Region: COG3431 743299000205 outer membrane porin, OprD family; Region: OprD; pfam03573 743299000206 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 743299000207 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 743299000208 Walker A/P-loop; other site 743299000209 ATP binding site [chemical binding]; other site 743299000210 Q-loop/lid; other site 743299000211 ABC transporter signature motif; other site 743299000212 Walker B; other site 743299000213 D-loop; other site 743299000214 H-loop/switch region; other site 743299000215 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 743299000216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743299000217 dimer interface [polypeptide binding]; other site 743299000218 conserved gate region; other site 743299000219 putative PBP binding loops; other site 743299000220 ABC-ATPase subunit interface; other site 743299000221 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 743299000222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 743299000223 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 743299000224 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 743299000225 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 743299000226 FAD binding pocket [chemical binding]; other site 743299000227 FAD binding motif [chemical binding]; other site 743299000228 phosphate binding motif [ion binding]; other site 743299000229 beta-alpha-beta structure motif; other site 743299000230 NAD binding pocket [chemical binding]; other site 743299000231 Iron coordination center [ion binding]; other site 743299000232 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 743299000233 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 743299000234 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 743299000235 HEAT repeats; Region: HEAT_2; pfam13646 743299000236 HEAT repeats; Region: HEAT_2; pfam13646 743299000237 HEAT repeats; Region: HEAT_2; pfam13646 743299000238 HEAT repeats; Region: HEAT_2; pfam13646 743299000239 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 743299000240 putative oxidoreductase; Provisional; Region: PRK08275 743299000241 L-aspartate oxidase; Provisional; Region: PRK06175 743299000242 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 743299000243 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 743299000244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743299000245 DNA-binding site [nucleotide binding]; DNA binding site 743299000246 UTRA domain; Region: UTRA; pfam07702 743299000247 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 743299000248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299000249 FeS/SAM binding site; other site 743299000250 HemN C-terminal domain; Region: HemN_C; pfam06969 743299000251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743299000252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743299000253 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 743299000254 putative dimerization interface [polypeptide binding]; other site 743299000255 outer membrane porin, OprD family; Region: OprD; pfam03573 743299000256 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 743299000257 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 743299000258 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 743299000259 putative active site [active] 743299000260 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 743299000261 FAD binding domain; Region: FAD_binding_4; pfam01565 743299000262 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 743299000263 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 743299000264 dimer interface [polypeptide binding]; other site 743299000265 active site 743299000266 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 743299000267 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 743299000268 active site 743299000269 nucleotide binding site [chemical binding]; other site 743299000270 HIGH motif; other site 743299000271 KMSKS motif; other site 743299000272 hypothetical protein; Reviewed; Region: PRK12497 743299000273 LppC putative lipoprotein; Region: LppC; pfam04348 743299000274 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 743299000275 Predicted methyltransferases [General function prediction only]; Region: COG0313 743299000276 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 743299000277 putative SAM binding site [chemical binding]; other site 743299000278 putative homodimer interface [polypeptide binding]; other site 743299000279 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 743299000280 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 743299000281 ResB-like family; Region: ResB; pfam05140 743299000282 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 743299000283 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 743299000284 DNA-binding site [nucleotide binding]; DNA binding site 743299000285 RNA-binding motif; other site 743299000286 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743299000287 GAF domain; Region: GAF_3; pfam13492 743299000288 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743299000289 GAF domain; Region: GAF; pfam01590 743299000290 PAS domain; Region: PAS_9; pfam13426 743299000291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743299000292 putative active site [active] 743299000293 heme pocket [chemical binding]; other site 743299000294 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299000295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299000296 metal binding site [ion binding]; metal-binding site 743299000297 active site 743299000298 I-site; other site 743299000299 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299000300 ribonuclease G; Provisional; Region: PRK11712 743299000301 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 743299000302 homodimer interface [polypeptide binding]; other site 743299000303 oligonucleotide binding site [chemical binding]; other site 743299000304 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 743299000305 Maf-like protein; Region: Maf; pfam02545 743299000306 active site 743299000307 dimer interface [polypeptide binding]; other site 743299000308 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 743299000309 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 743299000310 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 743299000311 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 743299000312 active site 743299000313 (T/H)XGH motif; other site 743299000314 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299000315 methionine sulfoxide reductase A; Provisional; Region: PRK13014 743299000316 methionine sulfoxide reductase B; Provisional; Region: PRK00222 743299000317 SelR domain; Region: SelR; pfam01641 743299000318 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 743299000319 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 743299000320 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 743299000321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743299000322 DNA binding site [nucleotide binding] 743299000323 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 743299000324 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743299000325 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 743299000326 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743299000327 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743299000328 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743299000329 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743299000330 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 743299000331 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743299000332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299000333 motif II; other site 743299000334 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 743299000335 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 743299000336 AAA domain; Region: AAA_30; pfam13604 743299000337 Family description; Region: UvrD_C_2; pfam13538 743299000338 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 743299000339 Family description; Region: UvrD_C_2; pfam13538 743299000340 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 743299000341 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 743299000342 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 743299000343 hypothetical protein; Provisional; Region: PRK05409 743299000344 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 743299000345 putative acyl-acceptor binding pocket; other site 743299000346 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 743299000347 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 743299000348 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 743299000349 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 743299000350 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 743299000351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299000352 S-adenosylmethionine binding site [chemical binding]; other site 743299000353 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 743299000354 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 743299000355 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 743299000356 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 743299000357 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 743299000358 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 743299000359 Predicted transcriptional regulator [Transcription]; Region: COG2944 743299000360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743299000361 non-specific DNA binding site [nucleotide binding]; other site 743299000362 salt bridge; other site 743299000363 sequence-specific DNA binding site [nucleotide binding]; other site 743299000364 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 743299000365 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743299000366 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 743299000367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299000368 S-adenosylmethionine binding site [chemical binding]; other site 743299000369 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 743299000370 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 743299000371 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743299000372 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743299000373 ligand binding site [chemical binding]; other site 743299000374 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 743299000375 Tetratricopeptide repeat; Region: TPR_6; pfam13174 743299000376 Tetratricopeptide repeat; Region: TPR_6; pfam13174 743299000377 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 743299000378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299000379 FeS/SAM binding site; other site 743299000380 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 743299000381 Ligand Binding Site [chemical binding]; other site 743299000382 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 743299000383 TolB amino-terminal domain; Region: TolB_N; pfam04052 743299000384 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743299000385 TolA protein; Region: tolA_full; TIGR02794 743299000386 Gram-negative bacterial tonB protein; Region: TonB; cl10048 743299000387 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743299000388 TolR protein; Region: tolR; TIGR02801 743299000389 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 743299000390 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743299000391 active site 743299000392 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 743299000393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299000394 Walker A motif; other site 743299000395 ATP binding site [chemical binding]; other site 743299000396 Walker B motif; other site 743299000397 arginine finger; other site 743299000398 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 743299000399 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 743299000400 RuvA N terminal domain; Region: RuvA_N; pfam01330 743299000401 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 743299000402 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 743299000403 active site 743299000404 putative DNA-binding cleft [nucleotide binding]; other site 743299000405 dimer interface [polypeptide binding]; other site 743299000406 hypothetical protein; Validated; Region: PRK00110 743299000407 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743299000408 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743299000409 putative acyl-acceptor binding pocket; other site 743299000410 quinolinate synthetase; Provisional; Region: PRK09375 743299000411 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 743299000412 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 743299000413 dimer interface [polypeptide binding]; other site 743299000414 anticodon binding site; other site 743299000415 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 743299000416 homodimer interface [polypeptide binding]; other site 743299000417 motif 1; other site 743299000418 active site 743299000419 motif 2; other site 743299000420 GAD domain; Region: GAD; pfam02938 743299000421 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 743299000422 motif 3; other site 743299000423 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 743299000424 MarC family integral membrane protein; Region: MarC; cl00919 743299000425 Domain of unknown function (DUF202); Region: DUF202; pfam02656 743299000426 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 743299000427 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743299000428 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743299000429 ABC transporter; Region: ABC_tran_2; pfam12848 743299000430 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743299000431 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 743299000432 Ribonuclease P; Region: Ribonuclease_P; pfam00825 743299000433 Haemolytic domain; Region: Haemolytic; pfam01809 743299000434 membrane protein insertase; Provisional; Region: PRK01318 743299000435 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 743299000436 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 743299000437 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 743299000438 trmE is a tRNA modification GTPase; Region: trmE; cd04164 743299000439 G1 box; other site 743299000440 GTP/Mg2+ binding site [chemical binding]; other site 743299000441 Switch I region; other site 743299000442 G2 box; other site 743299000443 Switch II region; other site 743299000444 G3 box; other site 743299000445 G4 box; other site 743299000446 G5 box; other site 743299000447 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 743299000448 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 743299000449 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 743299000450 Protein of unknown function DUF45; Region: DUF45; pfam01863 743299000451 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 743299000452 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 743299000453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299000454 ATP binding site [chemical binding]; other site 743299000455 putative Mg++ binding site [ion binding]; other site 743299000456 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 743299000457 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 743299000458 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 743299000459 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 743299000460 Virulence protein [General function prediction only]; Region: COG3943 743299000461 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 743299000462 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 743299000463 HsdM N-terminal domain; Region: HsdM_N; pfam12161 743299000464 Methyltransferase domain; Region: Methyltransf_26; pfam13659 743299000465 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 743299000466 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 743299000467 ABC-2 type transporter; Region: ABC2_membrane; cl17235 743299000468 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 743299000469 nodulation ABC transporter NodI; Provisional; Region: PRK13537 743299000470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299000471 Walker A/P-loop; other site 743299000472 ATP binding site [chemical binding]; other site 743299000473 Q-loop/lid; other site 743299000474 ABC transporter signature motif; other site 743299000475 Walker B; other site 743299000476 D-loop; other site 743299000477 H-loop/switch region; other site 743299000478 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 743299000479 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 743299000480 dimer interface [polypeptide binding]; other site 743299000481 [2Fe-2S] cluster binding site [ion binding]; other site 743299000482 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 743299000483 diiron binding motif [ion binding]; other site 743299000484 Rrf2 family protein; Region: rrf2_super; TIGR00738 743299000485 Transcriptional regulator; Region: Rrf2; pfam02082 743299000486 OsmC-like protein; Region: OsmC; cl00767 743299000487 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 743299000488 active site 743299000489 ribulose/triose binding site [chemical binding]; other site 743299000490 phosphate binding site [ion binding]; other site 743299000491 substrate (anthranilate) binding pocket [chemical binding]; other site 743299000492 product (indole) binding pocket [chemical binding]; other site 743299000493 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 743299000494 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 743299000495 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 743299000496 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 743299000497 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 743299000498 glutamine binding [chemical binding]; other site 743299000499 catalytic triad [active] 743299000500 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 743299000501 Divergent AAA domain; Region: AAA_4; pfam04326 743299000502 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 743299000503 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 743299000504 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 743299000505 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 743299000506 anthranilate synthase component I; Provisional; Region: PRK13565 743299000507 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 743299000508 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 743299000509 phosphoglycolate phosphatase; Provisional; Region: PRK13222 743299000510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299000511 motif II; other site 743299000512 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 743299000513 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 743299000514 substrate binding site [chemical binding]; other site 743299000515 hexamer interface [polypeptide binding]; other site 743299000516 metal binding site [ion binding]; metal-binding site 743299000517 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 743299000518 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 743299000519 intersubunit interface [polypeptide binding]; other site 743299000520 active site 743299000521 zinc binding site [ion binding]; other site 743299000522 Na+ binding site [ion binding]; other site 743299000523 pyruvate kinase; Provisional; Region: PRK05826 743299000524 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 743299000525 domain interfaces; other site 743299000526 active site 743299000527 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 743299000528 Phosphoglycerate kinase; Region: PGK; pfam00162 743299000529 substrate binding site [chemical binding]; other site 743299000530 hinge regions; other site 743299000531 ADP binding site [chemical binding]; other site 743299000532 catalytic site [active] 743299000533 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 743299000534 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 743299000535 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 743299000536 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 743299000537 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 743299000538 TPP-binding site [chemical binding]; other site 743299000539 dimer interface [polypeptide binding]; other site 743299000540 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 743299000541 PYR/PP interface [polypeptide binding]; other site 743299000542 dimer interface [polypeptide binding]; other site 743299000543 TPP binding site [chemical binding]; other site 743299000544 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743299000545 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 743299000546 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 743299000547 putative active site [active] 743299000548 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 743299000549 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 743299000550 active site 743299000551 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 743299000552 RNA methyltransferase, RsmE family; Region: TIGR00046 743299000553 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 743299000554 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 743299000555 oligomer interface [polypeptide binding]; other site 743299000556 metal binding site [ion binding]; metal-binding site 743299000557 metal binding site [ion binding]; metal-binding site 743299000558 putative Cl binding site [ion binding]; other site 743299000559 basic sphincter; other site 743299000560 hydrophobic gate; other site 743299000561 periplasmic entrance; other site 743299000562 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 743299000563 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 743299000564 RmuC family; Region: RmuC; pfam02646 743299000565 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 743299000566 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 743299000567 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 743299000568 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743299000569 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743299000570 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743299000571 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299000572 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 743299000573 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 743299000574 dimer interface [polypeptide binding]; other site 743299000575 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743299000576 metal binding site [ion binding]; metal-binding site 743299000577 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 743299000578 classical (c) SDRs; Region: SDR_c; cd05233 743299000579 NAD(P) binding site [chemical binding]; other site 743299000580 active site 743299000581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743299000582 Coenzyme A binding pocket [chemical binding]; other site 743299000583 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 743299000584 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 743299000585 PIN domain; Region: PIN_3; cl17397 743299000586 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743299000587 Cytochrome C' Region: Cytochrom_C_2; pfam01322 743299000588 EamA-like transporter family; Region: EamA; pfam00892 743299000589 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 743299000590 dimer interface [polypeptide binding]; other site 743299000591 osmolarity response regulator; Provisional; Region: ompR; PRK09468 743299000592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299000593 active site 743299000594 phosphorylation site [posttranslational modification] 743299000595 intermolecular recognition site; other site 743299000596 dimerization interface [polypeptide binding]; other site 743299000597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743299000598 DNA binding site [nucleotide binding] 743299000599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743299000600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743299000601 dimerization interface [polypeptide binding]; other site 743299000602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299000603 dimer interface [polypeptide binding]; other site 743299000604 phosphorylation site [posttranslational modification] 743299000605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299000606 ATP binding site [chemical binding]; other site 743299000607 Mg2+ binding site [ion binding]; other site 743299000608 G-X-G motif; other site 743299000609 argininosuccinate lyase; Provisional; Region: PRK00855 743299000610 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 743299000611 active sites [active] 743299000612 tetramer interface [polypeptide binding]; other site 743299000613 diaminopimelate decarboxylase; Region: lysA; TIGR01048 743299000614 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 743299000615 active site 743299000616 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743299000617 substrate binding site [chemical binding]; other site 743299000618 catalytic residues [active] 743299000619 dimer interface [polypeptide binding]; other site 743299000620 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 743299000621 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 743299000622 active site 743299000623 dimer interface [polypeptide binding]; other site 743299000624 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 743299000625 dimer interface [polypeptide binding]; other site 743299000626 active site 743299000627 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 743299000628 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 743299000629 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 743299000630 glutathionine S-transferase; Provisional; Region: PRK10542 743299000631 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 743299000632 C-terminal domain interface [polypeptide binding]; other site 743299000633 GSH binding site (G-site) [chemical binding]; other site 743299000634 dimer interface [polypeptide binding]; other site 743299000635 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 743299000636 N-terminal domain interface [polypeptide binding]; other site 743299000637 dimer interface [polypeptide binding]; other site 743299000638 substrate binding pocket (H-site) [chemical binding]; other site 743299000639 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 743299000640 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743299000641 Predicted transcriptional regulators [Transcription]; Region: COG1733 743299000642 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 743299000643 Uncharacterized conserved protein [Function unknown]; Region: COG2353 743299000644 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 743299000645 catalytic residues [active] 743299000646 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743299000647 metal-binding site [ion binding] 743299000648 Domain of unknown function DUF302; Region: DUF302; pfam03625 743299000649 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743299000650 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743299000651 metal-binding site [ion binding] 743299000652 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743299000653 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743299000654 metal-binding site [ion binding] 743299000655 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743299000656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299000657 active site 743299000658 motif I; other site 743299000659 motif II; other site 743299000660 voltage-gated potassium channel; Provisional; Region: PRK10537 743299000661 Ion channel; Region: Ion_trans_2; pfam07885 743299000662 TrkA-N domain; Region: TrkA_N; pfam02254 743299000663 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 743299000664 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 743299000665 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 743299000666 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 743299000667 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 743299000668 catalytic triad [active] 743299000669 GAF domain; Region: GAF_3; pfam13492 743299000670 GAF domain; Region: GAF_2; pfam13185 743299000671 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299000672 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299000673 metal binding site [ion binding]; metal-binding site 743299000674 active site 743299000675 I-site; other site 743299000676 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299000677 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 743299000678 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 743299000679 anti sigma factor interaction site; other site 743299000680 regulatory phosphorylation site [posttranslational modification]; other site 743299000681 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 743299000682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743299000683 PAS domain; Region: PAS_9; pfam13426 743299000684 putative active site [active] 743299000685 heme pocket [chemical binding]; other site 743299000686 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 743299000687 ammonium transporter; Region: amt; TIGR00836 743299000688 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 743299000689 Nitrogen regulatory protein P-II; Region: P-II; smart00938 743299000690 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 743299000691 SpoVR family protein; Provisional; Region: PRK11767 743299000692 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 743299000693 hypothetical protein; Provisional; Region: PRK05325 743299000694 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 743299000695 PrkA family serine protein kinase; Provisional; Region: PRK15455 743299000696 AAA ATPase domain; Region: AAA_16; pfam13191 743299000697 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 743299000698 Cache domain; Region: Cache_1; pfam02743 743299000699 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 743299000700 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 743299000701 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 743299000702 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 743299000703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 743299000704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 743299000705 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 743299000706 Uncharacterized conserved protein [Function unknown]; Region: COG2308 743299000707 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 743299000708 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 743299000709 active site 743299000710 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743299000711 PAS domain; Region: PAS; smart00091 743299000712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299000713 dimer interface [polypeptide binding]; other site 743299000714 phosphorylation site [posttranslational modification] 743299000715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299000716 ATP binding site [chemical binding]; other site 743299000717 Mg2+ binding site [ion binding]; other site 743299000718 G-X-G motif; other site 743299000719 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 743299000720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299000721 active site 743299000722 phosphorylation site [posttranslational modification] 743299000723 intermolecular recognition site; other site 743299000724 dimerization interface [polypeptide binding]; other site 743299000725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299000726 Walker A motif; other site 743299000727 ATP binding site [chemical binding]; other site 743299000728 Walker B motif; other site 743299000729 arginine finger; other site 743299000730 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743299000731 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 743299000732 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 743299000733 substrate binding pocket [chemical binding]; other site 743299000734 chain length determination region; other site 743299000735 substrate-Mg2+ binding site; other site 743299000736 catalytic residues [active] 743299000737 aspartate-rich region 1; other site 743299000738 active site lid residues [active] 743299000739 aspartate-rich region 2; other site 743299000740 O-Antigen ligase; Region: Wzy_C; pfam04932 743299000741 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 743299000742 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 743299000743 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 743299000744 ABC transporter ATPase component; Reviewed; Region: PRK11147 743299000745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299000746 Walker A/P-loop; other site 743299000747 ATP binding site [chemical binding]; other site 743299000748 Q-loop/lid; other site 743299000749 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743299000750 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743299000751 Tic20-like protein; Region: Tic20; pfam09685 743299000752 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 743299000753 Fe-S cluster binding site [ion binding]; other site 743299000754 active site 743299000755 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 743299000756 active site 743299000757 catalytic triad [active] 743299000758 oxyanion hole [active] 743299000759 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 743299000760 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 743299000761 catalytic residue [active] 743299000762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299000763 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 743299000764 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 743299000765 ATP binding site [chemical binding]; other site 743299000766 Walker A motif; other site 743299000767 hexamer interface [polypeptide binding]; other site 743299000768 Walker B motif; other site 743299000769 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 743299000770 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 743299000771 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 743299000772 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 743299000773 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 743299000774 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743299000775 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743299000776 ligand binding site [chemical binding]; other site 743299000777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743299000778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743299000779 DNA binding residues [nucleotide binding] 743299000780 dimerization interface [polypeptide binding]; other site 743299000781 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 743299000782 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743299000783 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743299000784 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 743299000785 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743299000786 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 743299000787 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 743299000788 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 743299000789 putative active site [active] 743299000790 signal recognition particle protein; Provisional; Region: PRK10867 743299000791 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 743299000792 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 743299000793 P loop; other site 743299000794 GTP binding site [chemical binding]; other site 743299000795 Signal peptide binding domain; Region: SRP_SPB; pfam02978 743299000796 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 743299000797 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 743299000798 RimM N-terminal domain; Region: RimM; pfam01782 743299000799 PRC-barrel domain; Region: PRC; pfam05239 743299000800 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 743299000801 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 743299000802 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 743299000803 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743299000804 active site 743299000805 DNA binding site [nucleotide binding] 743299000806 Int/Topo IB signature motif; other site 743299000807 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 743299000808 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 743299000809 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743299000810 protein binding site [polypeptide binding]; other site 743299000811 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743299000812 protein binding site [polypeptide binding]; other site 743299000813 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 743299000814 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743299000815 catalytic residues [active] 743299000816 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 743299000817 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 743299000818 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 743299000819 Branched-chain amino acid ATP-binding cassette transporter; Region: BCA_ABC_TP_C; pfam12399 743299000820 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 743299000821 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 743299000822 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 743299000823 dimer interface [polypeptide binding]; other site 743299000824 ssDNA binding site [nucleotide binding]; other site 743299000825 tetramer (dimer of dimers) interface [polypeptide binding]; other site 743299000826 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 743299000827 HsdM N-terminal domain; Region: HsdM_N; pfam12161 743299000828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299000829 S-adenosylmethionine binding site [chemical binding]; other site 743299000830 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 743299000831 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 743299000832 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 743299000833 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 743299000834 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 743299000835 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 743299000836 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 743299000837 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299000838 ATP binding site [chemical binding]; other site 743299000839 putative Mg++ binding site [ion binding]; other site 743299000840 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 743299000841 Protein of unknown function (DUF445); Region: DUF445; pfam04286 743299000842 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 743299000843 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 743299000844 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 743299000845 nucleotide binding site [chemical binding]; other site 743299000846 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 743299000847 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 743299000848 active site 743299000849 catalytic site [active] 743299000850 homodimer interface [polypeptide binding]; other site 743299000851 Lid 1; other site 743299000852 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 743299000853 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 743299000854 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 743299000855 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 743299000856 putative active site [active] 743299000857 catalytic site [active] 743299000858 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 743299000859 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 743299000860 ligand binding site; other site 743299000861 oligomer interface; other site 743299000862 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 743299000863 dimer interface [polypeptide binding]; other site 743299000864 N-terminal domain interface [polypeptide binding]; other site 743299000865 sulfate 1 binding site; other site 743299000866 glycogen branching enzyme; Provisional; Region: PRK05402 743299000867 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 743299000868 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 743299000869 active site 743299000870 catalytic site [active] 743299000871 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 743299000872 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 743299000873 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 743299000874 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 743299000875 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 743299000876 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 743299000877 putative active site [active] 743299000878 cysteine synthase B; Region: cysM; TIGR01138 743299000879 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 743299000880 dimer interface [polypeptide binding]; other site 743299000881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299000882 catalytic residue [active] 743299000883 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 743299000884 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 743299000885 active site 743299000886 catalytic site [active] 743299000887 substrate binding site [chemical binding]; other site 743299000888 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 743299000889 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 743299000890 TRAM domain; Region: TRAM; cl01282 743299000891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299000892 S-adenosylmethionine binding site [chemical binding]; other site 743299000893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 743299000894 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 743299000895 Amino acid permease; Region: AA_permease_2; pfam13520 743299000896 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 743299000897 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 743299000898 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 743299000899 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 743299000900 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 743299000901 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 743299000902 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 743299000903 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 743299000904 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 743299000905 replicative DNA helicase; Region: DnaB; TIGR00665 743299000906 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 743299000907 Walker A motif; other site 743299000908 ATP binding site [chemical binding]; other site 743299000909 Walker B motif; other site 743299000910 DNA binding loops [nucleotide binding] 743299000911 alanine racemase; Reviewed; Region: alr; PRK00053 743299000912 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 743299000913 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743299000914 catalytic residue [active] 743299000915 DNA repair protein RadA; Provisional; Region: PRK11823 743299000916 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 743299000917 Walker A motif/ATP binding site; other site 743299000918 ATP binding site [chemical binding]; other site 743299000919 Walker B motif; other site 743299000920 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 743299000921 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 743299000922 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 743299000923 proline aminopeptidase P II; Provisional; Region: PRK10879 743299000924 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 743299000925 active site 743299000926 MAEBL; Provisional; Region: PTZ00121 743299000927 putative phosphoketolase; Provisional; Region: PRK05261 743299000928 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 743299000929 TPP-binding site; other site 743299000930 XFP C-terminal domain; Region: XFP_C; pfam09363 743299000931 Short C-terminal domain; Region: SHOCT; pfam09851 743299000932 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 743299000933 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 743299000934 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 743299000935 active site 743299000936 catalytic residues [active] 743299000937 DNA binding site [nucleotide binding] 743299000938 Int/Topo IB signature motif; other site 743299000939 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 743299000940 Uncharacterized conserved protein [Function unknown]; Region: COG1479 743299000941 Protein of unknown function DUF262; Region: DUF262; pfam03235 743299000942 Protein of unknown function DUF262; Region: DUF262; pfam03235 743299000943 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 743299000944 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 743299000945 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 743299000946 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743299000947 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743299000948 short chain dehydrogenase; Provisional; Region: PRK07326 743299000949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299000950 NAD(P) binding site [chemical binding]; other site 743299000951 active site 743299000952 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743299000953 IHF dimer interface [polypeptide binding]; other site 743299000954 IHF - DNA interface [nucleotide binding]; other site 743299000955 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 743299000956 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 743299000957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299000958 ATP binding site [chemical binding]; other site 743299000959 putative Mg++ binding site [ion binding]; other site 743299000960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743299000961 nucleotide binding region [chemical binding]; other site 743299000962 ATP-binding site [chemical binding]; other site 743299000963 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 743299000964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299000965 ATP binding site [chemical binding]; other site 743299000966 putative Mg++ binding site [ion binding]; other site 743299000967 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 743299000968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743299000969 nucleotide binding region [chemical binding]; other site 743299000970 ATP-binding site [chemical binding]; other site 743299000971 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 743299000972 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 743299000973 putative active site [active] 743299000974 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 743299000975 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 743299000976 VirC1 protein; Region: VirC1; cl17401 743299000977 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 743299000978 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 743299000979 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 743299000980 addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607 743299000981 non-specific DNA binding site [nucleotide binding]; other site 743299000982 salt bridge; other site 743299000983 sequence-specific DNA binding site [nucleotide binding]; other site 743299000984 HNH endonuclease; Region: HNH_2; pfam13391 743299000985 EamA-like transporter family; Region: EamA; pfam00892 743299000986 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 743299000987 EamA-like transporter family; Region: EamA; pfam00892 743299000988 DinB family; Region: DinB; cl17821 743299000989 DinB superfamily; Region: DinB_2; pfam12867 743299000990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299000991 putative substrate translocation pore; other site 743299000992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743299000993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 743299000994 SnoaL-like domain; Region: SnoaL_2; pfam12680 743299000995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743299000996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743299000997 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 743299000998 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 743299000999 AlkA N-terminal domain; Region: AlkA_N; pfam06029 743299001000 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 743299001001 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743299001002 minor groove reading motif; other site 743299001003 helix-hairpin-helix signature motif; other site 743299001004 substrate binding pocket [chemical binding]; other site 743299001005 active site 743299001006 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743299001007 dimerization interface [polypeptide binding]; other site 743299001008 putative DNA binding site [nucleotide binding]; other site 743299001009 putative Zn2+ binding site [ion binding]; other site 743299001010 Protein of unknown function (DUF421); Region: DUF421; cl00990 743299001011 putative transposase OrfB; Reviewed; Region: PHA02517 743299001012 HTH-like domain; Region: HTH_21; pfam13276 743299001013 Integrase core domain; Region: rve; pfam00665 743299001014 Integrase core domain; Region: rve_3; pfam13683 743299001015 Restriction endonuclease; Region: Mrr_cat; pfam04471 743299001016 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 743299001017 integrase; Provisional; Region: int; PHA02601 743299001018 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743299001019 active site 743299001020 DNA binding site [nucleotide binding] 743299001021 Int/Topo IB signature motif; other site 743299001022 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743299001023 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743299001024 active site 743299001025 DNA binding site [nucleotide binding] 743299001026 Int/Topo IB signature motif; other site 743299001027 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 743299001028 ParB-like nuclease domain; Region: ParBc; pfam02195 743299001029 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 743299001030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743299001031 non-specific DNA binding site [nucleotide binding]; other site 743299001032 salt bridge; other site 743299001033 sequence-specific DNA binding site [nucleotide binding]; other site 743299001034 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 743299001035 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 743299001036 Zn binding site [ion binding]; other site 743299001037 toxin interface [polypeptide binding]; other site 743299001038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743299001039 non-specific DNA binding site [nucleotide binding]; other site 743299001040 salt bridge; other site 743299001041 sequence-specific DNA binding site [nucleotide binding]; other site 743299001042 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 743299001043 peptide binding site [polypeptide binding]; other site 743299001044 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 743299001045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 743299001046 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 743299001047 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743299001048 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743299001049 catalytic residue [active] 743299001050 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 743299001051 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 743299001052 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 743299001053 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 743299001054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743299001055 DNA binding residues [nucleotide binding] 743299001056 Uncharacterized conserved protein [Function unknown]; Region: COG2442 743299001057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 743299001058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299001059 Walker A/P-loop; other site 743299001060 ATP binding site [chemical binding]; other site 743299001061 AAA ATPase domain; Region: AAA_15; pfam13175 743299001062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299001063 Walker B; other site 743299001064 D-loop; other site 743299001065 H-loop/switch region; other site 743299001066 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 743299001067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299001068 Walker A motif; other site 743299001069 ATP binding site [chemical binding]; other site 743299001070 Walker B motif; other site 743299001071 Family description; Region: UvrD_C_2; pfam13538 743299001072 AAA-like domain; Region: AAA_10; pfam12846 743299001073 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 743299001074 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 743299001075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743299001076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743299001077 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 743299001078 putative dimerization interface [polypeptide binding]; other site 743299001079 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 743299001080 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 743299001081 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743299001082 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 743299001083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 743299001084 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743299001085 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 743299001086 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 743299001087 MarR family; Region: MarR_2; pfam12802 743299001088 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 743299001089 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 743299001090 YceI-like domain; Region: YceI; cl01001 743299001091 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743299001092 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 743299001093 active site 743299001094 metal binding site [ion binding]; metal-binding site 743299001095 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299001096 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299001097 metal binding site [ion binding]; metal-binding site 743299001098 active site 743299001099 I-site; other site 743299001100 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299001101 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 743299001102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 743299001103 Transposase; Region: DEDD_Tnp_IS110; pfam01548 743299001104 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 743299001105 Protein of unknown function, DUF481; Region: DUF481; pfam04338 743299001106 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 743299001107 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 743299001108 putative active site [active] 743299001109 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 743299001110 rusticyanin; Region: rusti_cyanin; TIGR03095 743299001111 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 743299001112 Transposase [DNA replication, recombination, and repair]; Region: COG5421 743299001113 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 743299001114 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 743299001115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743299001116 Coenzyme A binding pocket [chemical binding]; other site 743299001117 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743299001118 intersubunit interface [polypeptide binding]; other site 743299001119 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 743299001120 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 743299001121 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 743299001122 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 743299001123 MgtC family; Region: MgtC; pfam02308 743299001124 acyl carrier protein; Provisional; Region: acpP; PRK00982 743299001125 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 743299001126 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 743299001127 DNA binding residues [nucleotide binding] 743299001128 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 743299001129 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 743299001130 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 743299001131 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 743299001132 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743299001133 catalytic residue [active] 743299001134 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 743299001135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299001136 binding surface 743299001137 TPR motif; other site 743299001138 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 743299001139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299001140 TPR motif; other site 743299001141 binding surface 743299001142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299001143 binding surface 743299001144 TPR motif; other site 743299001145 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 743299001146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299001147 binding surface 743299001148 TPR motif; other site 743299001149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299001150 binding surface 743299001151 TPR motif; other site 743299001152 TPR repeat; Region: TPR_11; pfam13414 743299001153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299001154 binding surface 743299001155 TPR motif; other site 743299001156 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 743299001157 Outer membrane efflux protein; Region: OEP; pfam02321 743299001158 Outer membrane efflux protein; Region: OEP; pfam02321 743299001159 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 743299001160 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743299001161 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299001162 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 743299001163 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743299001164 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 743299001165 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 743299001166 Transposase [DNA replication, recombination, and repair]; Region: COG5421 743299001167 Transposase [DNA replication, recombination, and repair]; Region: COG5421 743299001168 TrwC relaxase; Region: TrwC; pfam08751 743299001169 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 743299001170 AAA domain; Region: AAA_30; pfam13604 743299001171 Family description; Region: UvrD_C_2; pfam13538 743299001172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299001173 AAA domain; Region: AAA_27; pfam13514 743299001174 Walker A/P-loop; other site 743299001175 ATP binding site [chemical binding]; other site 743299001176 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 743299001177 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743299001178 active site 743299001179 metal binding site [ion binding]; metal-binding site 743299001180 DNA binding site [nucleotide binding] 743299001181 Helix-turn-helix domain; Region: HTH_17; pfam12728 743299001182 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 743299001183 putative active site [active] 743299001184 catalytic site [active] 743299001185 DEAD-like helicases superfamily; Region: DEXDc; smart00487 743299001186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299001187 ATP binding site [chemical binding]; other site 743299001188 putative Mg++ binding site [ion binding]; other site 743299001189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743299001190 nucleotide binding region [chemical binding]; other site 743299001191 ATP-binding site [chemical binding]; other site 743299001192 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 743299001193 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 743299001194 DNA methylase; Region: N6_N4_Mtase; pfam01555 743299001195 DNA methylase; Region: N6_N4_Mtase; cl17433 743299001196 Restriction endonuclease [Defense mechanisms]; Region: COG3587 743299001197 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299001198 ATP binding site [chemical binding]; other site 743299001199 putative Mg++ binding site [ion binding]; other site 743299001200 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299001201 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299001202 metal binding site [ion binding]; metal-binding site 743299001203 active site 743299001204 I-site; other site 743299001205 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 743299001206 Toprim domain; Region: Toprim_3; pfam13362 743299001207 cysteine-tRNA ligase; Region: PLN02946 743299001208 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 743299001209 Mg binding site [ion binding]; other site 743299001210 nucleotide binding site [chemical binding]; other site 743299001211 putative protofilament interface [polypeptide binding]; other site 743299001212 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 743299001213 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299001214 Walker A motif; other site 743299001215 ATP binding site [chemical binding]; other site 743299001216 Walker B motif; other site 743299001217 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 743299001218 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 743299001219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743299001220 active site 743299001221 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 743299001222 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 743299001223 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 743299001224 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 743299001225 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 743299001226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299001227 Tetratricopeptide repeat; Region: TPR_16; pfam13432 743299001228 TPR motif; other site 743299001229 binding surface 743299001230 Tetratricopeptide repeat; Region: TPR_16; pfam13432 743299001231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299001232 TPR motif; other site 743299001233 binding surface 743299001234 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 743299001235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299001236 binding surface 743299001237 TPR motif; other site 743299001238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299001239 binding surface 743299001240 TPR motif; other site 743299001241 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 743299001242 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 743299001243 tRNA; other site 743299001244 putative tRNA binding site [nucleotide binding]; other site 743299001245 putative NADP binding site [chemical binding]; other site 743299001246 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 743299001247 peptide chain release factor 1; Validated; Region: prfA; PRK00591 743299001248 This domain is found in peptide chain release factors; Region: PCRF; smart00937 743299001249 RF-1 domain; Region: RF-1; pfam00472 743299001250 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 743299001251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299001252 S-adenosylmethionine binding site [chemical binding]; other site 743299001253 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 743299001254 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 743299001255 DNA binding site [nucleotide binding] 743299001256 catalytic residue [active] 743299001257 H2TH interface [polypeptide binding]; other site 743299001258 putative catalytic residues [active] 743299001259 turnover-facilitating residue; other site 743299001260 intercalation triad [nucleotide binding]; other site 743299001261 8OG recognition residue [nucleotide binding]; other site 743299001262 putative reading head residues; other site 743299001263 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 743299001264 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 743299001265 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 743299001266 G1 box; other site 743299001267 GTP/Mg2+ binding site [chemical binding]; other site 743299001268 G2 box; other site 743299001269 Switch I region; other site 743299001270 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 743299001271 G3 box; other site 743299001272 Switch II region; other site 743299001273 GTP/Mg2+ binding site [chemical binding]; other site 743299001274 G4 box; other site 743299001275 G5 box; other site 743299001276 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 743299001277 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 743299001278 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 743299001279 active site 743299001280 (T/H)XGH motif; other site 743299001281 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 743299001282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299001283 S-adenosylmethionine binding site [chemical binding]; other site 743299001284 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 743299001285 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 743299001286 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 743299001287 P loop; other site 743299001288 GTP binding site [chemical binding]; other site 743299001289 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 743299001290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299001291 Walker A/P-loop; other site 743299001292 ATP binding site [chemical binding]; other site 743299001293 Q-loop/lid; other site 743299001294 ABC transporter signature motif; other site 743299001295 Walker B; other site 743299001296 D-loop; other site 743299001297 H-loop/switch region; other site 743299001298 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 743299001299 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 743299001300 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 743299001301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743299001302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743299001303 DNA binding residues [nucleotide binding] 743299001304 DsrE/DsrF-like family; Region: DrsE; cl00672 743299001305 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 743299001306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299001307 Walker A motif; other site 743299001308 ATP binding site [chemical binding]; other site 743299001309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299001310 Walker B motif; other site 743299001311 arginine finger; other site 743299001312 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 743299001313 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 743299001314 active site 743299001315 HslU subunit interaction site [polypeptide binding]; other site 743299001316 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 743299001317 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743299001318 active site 743299001319 DNA binding site [nucleotide binding] 743299001320 Int/Topo IB signature motif; other site 743299001321 Protein of unknown function, DUF484; Region: DUF484; cl17449 743299001322 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 743299001323 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 743299001324 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 743299001325 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 743299001326 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 743299001327 G1 box; other site 743299001328 putative GEF interaction site [polypeptide binding]; other site 743299001329 GTP/Mg2+ binding site [chemical binding]; other site 743299001330 Switch I region; other site 743299001331 G2 box; other site 743299001332 G3 box; other site 743299001333 Switch II region; other site 743299001334 G4 box; other site 743299001335 G5 box; other site 743299001336 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 743299001337 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 743299001338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299001339 S-adenosylmethionine binding site [chemical binding]; other site 743299001340 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 743299001341 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 743299001342 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 743299001343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299001344 S-adenosylmethionine binding site [chemical binding]; other site 743299001345 hybrid cluster protein; Provisional; Region: PRK05290 743299001346 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 743299001347 ACS interaction site; other site 743299001348 CODH interaction site; other site 743299001349 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 743299001350 hybrid metal cluster; other site 743299001351 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 743299001352 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743299001353 catalytic loop [active] 743299001354 iron binding site [ion binding]; other site 743299001355 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 743299001356 FAD binding pocket [chemical binding]; other site 743299001357 conserved FAD binding motif [chemical binding]; other site 743299001358 phosphate binding motif [ion binding]; other site 743299001359 beta-alpha-beta structure motif; other site 743299001360 NAD binding pocket [chemical binding]; other site 743299001361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 743299001362 FIST C domain; Region: FIST_C; pfam10442 743299001363 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 743299001364 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743299001365 minor groove reading motif; other site 743299001366 helix-hairpin-helix signature motif; other site 743299001367 substrate binding pocket [chemical binding]; other site 743299001368 active site 743299001369 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 743299001370 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 743299001371 Beta-Casp domain; Region: Beta-Casp; smart01027 743299001372 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 743299001373 glycogen synthase; Provisional; Region: glgA; PRK00654 743299001374 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 743299001375 ADP-binding pocket [chemical binding]; other site 743299001376 homodimer interface [polypeptide binding]; other site 743299001377 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 743299001378 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 743299001379 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 743299001380 active site 743299001381 Zn binding site [ion binding]; other site 743299001382 fumarate hydratase; Reviewed; Region: fumC; PRK00485 743299001383 Class II fumarases; Region: Fumarase_classII; cd01362 743299001384 active site 743299001385 tetramer interface [polypeptide binding]; other site 743299001386 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 743299001387 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 743299001388 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 743299001389 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 743299001390 active site 743299001391 HIGH motif; other site 743299001392 KMSKS motif; other site 743299001393 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 743299001394 tRNA binding surface [nucleotide binding]; other site 743299001395 anticodon binding site; other site 743299001396 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 743299001397 dimer interface [polypeptide binding]; other site 743299001398 putative tRNA-binding site [nucleotide binding]; other site 743299001399 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 743299001400 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 743299001401 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 743299001402 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 743299001403 GrpE; Region: GrpE; pfam01025 743299001404 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 743299001405 dimer interface [polypeptide binding]; other site 743299001406 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 743299001407 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 743299001408 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 743299001409 nucleotide binding site [chemical binding]; other site 743299001410 chaperone protein DnaJ; Provisional; Region: PRK10767 743299001411 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743299001412 HSP70 interaction site [polypeptide binding]; other site 743299001413 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 743299001414 Zn binding sites [ion binding]; other site 743299001415 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 743299001416 dimer interface [polypeptide binding]; other site 743299001417 dihydrodipicolinate reductase; Provisional; Region: PRK00048 743299001418 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 743299001419 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 743299001420 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 743299001421 antiporter inner membrane protein; Provisional; Region: PRK11670 743299001422 Domain of unknown function DUF59; Region: DUF59; pfam01883 743299001423 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 743299001424 Walker A motif; other site 743299001425 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 743299001426 trimer interface [polypeptide binding]; other site 743299001427 active site 743299001428 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 743299001429 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 743299001430 active site 743299001431 FMN binding site [chemical binding]; other site 743299001432 substrate binding site [chemical binding]; other site 743299001433 putative catalytic residue [active] 743299001434 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 743299001435 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 743299001436 amphipathic channel; other site 743299001437 Asn-Pro-Ala signature motifs; other site 743299001438 trehalose synthase; Region: treS_nterm; TIGR02456 743299001439 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 743299001440 active site 743299001441 catalytic site [active] 743299001442 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 743299001443 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 743299001444 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 743299001445 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 743299001446 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 743299001447 active site 743299001448 catalytic site [active] 743299001449 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 743299001450 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 743299001451 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 743299001452 catalytic site [active] 743299001453 active site 743299001454 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 743299001455 putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507 743299001456 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 743299001457 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 743299001458 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 743299001459 active site 743299001460 catalytic site [active] 743299001461 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 743299001462 cytochrome b; Provisional; Region: CYTB; MTH00145 743299001463 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 743299001464 Qi binding site; other site 743299001465 intrachain domain interface; other site 743299001466 interchain domain interface [polypeptide binding]; other site 743299001467 heme bH binding site [chemical binding]; other site 743299001468 heme bL binding site [chemical binding]; other site 743299001469 Qo binding site; other site 743299001470 interchain domain interface [polypeptide binding]; other site 743299001471 intrachain domain interface; other site 743299001472 Qi binding site; other site 743299001473 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 743299001474 Qo binding site; other site 743299001475 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 743299001476 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 743299001477 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 743299001478 [2Fe-2S] cluster binding site [ion binding]; other site 743299001479 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 743299001480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299001481 NAD(P) binding site [chemical binding]; other site 743299001482 active site 743299001483 Cytochrome c; Region: Cytochrom_C; cl11414 743299001484 Cytochrome c; Region: Cytochrom_C; cl11414 743299001485 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 743299001486 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 743299001487 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743299001488 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 743299001489 substrate binding site [chemical binding]; other site 743299001490 dimerization interface [polypeptide binding]; other site 743299001491 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 743299001492 putative active site [active] 743299001493 transaldolase; Provisional; Region: PRK03903 743299001494 catalytic residue [active] 743299001495 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 743299001496 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 743299001497 NAD binding site [chemical binding]; other site 743299001498 homotetramer interface [polypeptide binding]; other site 743299001499 homodimer interface [polypeptide binding]; other site 743299001500 substrate binding site [chemical binding]; other site 743299001501 active site 743299001502 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743299001503 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743299001504 catalytic residue [active] 743299001505 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743299001506 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 743299001507 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743299001508 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 743299001509 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743299001510 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743299001511 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 743299001512 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 743299001513 HIGH motif; other site 743299001514 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 743299001515 active site 743299001516 KMSKS motif; other site 743299001517 aconitate hydratase; Validated; Region: PRK07229 743299001518 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 743299001519 substrate binding site [chemical binding]; other site 743299001520 ligand binding site [chemical binding]; other site 743299001521 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 743299001522 substrate binding site [chemical binding]; other site 743299001523 isocitrate dehydrogenase; Validated; Region: PRK06451 743299001524 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 743299001525 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 743299001526 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 743299001527 CoA-ligase; Region: Ligase_CoA; pfam00549 743299001528 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 743299001529 CoA binding domain; Region: CoA_binding; smart00881 743299001530 CoA-ligase; Region: Ligase_CoA; pfam00549 743299001531 NAD synthetase; Provisional; Region: PRK13981 743299001532 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 743299001533 multimer interface [polypeptide binding]; other site 743299001534 active site 743299001535 catalytic triad [active] 743299001536 protein interface 1 [polypeptide binding]; other site 743299001537 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 743299001538 homodimer interface [polypeptide binding]; other site 743299001539 NAD binding pocket [chemical binding]; other site 743299001540 ATP binding pocket [chemical binding]; other site 743299001541 Mg binding site [ion binding]; other site 743299001542 active-site loop [active] 743299001543 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 743299001544 Nitrogen regulatory protein P-II; Region: P-II; smart00938 743299001545 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 743299001546 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 743299001547 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743299001548 RNA binding surface [nucleotide binding]; other site 743299001549 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 743299001550 active site 743299001551 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 743299001552 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 743299001553 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 743299001554 Cupin domain; Region: Cupin_2; pfam07883 743299001555 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 743299001556 dimer interface [polypeptide binding]; other site 743299001557 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 743299001558 catalytic residue [active] 743299001559 metal binding site [ion binding]; metal-binding site 743299001560 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 743299001561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299001562 motif II; other site 743299001563 methylthioribulose-1-phosphate dehydratase; Region: salvage_mtnB; TIGR03328 743299001564 intersubunit interface [polypeptide binding]; other site 743299001565 active site 743299001566 Zn2+ binding site [ion binding]; other site 743299001567 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743299001568 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743299001569 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 743299001570 active site 743299001571 catalytic residues [active] 743299001572 metal binding site [ion binding]; metal-binding site 743299001573 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 743299001574 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743299001575 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 743299001576 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743299001577 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 743299001578 guanine deaminase; Provisional; Region: PRK09228 743299001579 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743299001580 active site 743299001581 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 743299001582 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 743299001583 active site 743299001584 purine riboside binding site [chemical binding]; other site 743299001585 Purine nucleoside permease (NUP); Region: NUP; cl17832 743299001586 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 743299001587 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 743299001588 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 743299001589 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 743299001590 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 743299001591 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 743299001592 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 743299001593 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 743299001594 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; cl17559 743299001595 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 743299001596 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 743299001597 XdhC Rossmann domain; Region: XdhC_C; pfam13478 743299001598 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 743299001599 amidase; Provisional; Region: PRK09201 743299001600 Amidase; Region: Amidase; cl11426 743299001601 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 743299001602 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 743299001603 active site 743299001604 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 743299001605 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 743299001606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743299001607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743299001608 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743299001609 dimerization interface [polypeptide binding]; other site 743299001610 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743299001611 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 743299001612 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743299001613 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 743299001614 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 743299001615 Na binding site [ion binding]; other site 743299001616 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 743299001617 active site 743299001618 catalytic motif [active] 743299001619 Zn binding site [ion binding]; other site 743299001620 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 743299001621 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743299001622 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743299001623 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 743299001624 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 743299001625 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 743299001626 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 743299001627 HsdM N-terminal domain; Region: HsdM_N; pfam12161 743299001628 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 743299001629 Methyltransferase domain; Region: Methyltransf_26; pfam13659 743299001630 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 743299001631 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 743299001632 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 743299001633 Uncharacterized conserved protein [Function unknown]; Region: COG4933 743299001634 AAA domain; Region: AAA_18; pfam13238 743299001635 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890 743299001636 Virulence protein [General function prediction only]; Region: COG3943 743299001637 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 743299001638 Fic/DOC family; Region: Fic; pfam02661 743299001639 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 743299001640 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 743299001641 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 743299001642 ATP binding site [chemical binding]; other site 743299001643 putative Mg++ binding site [ion binding]; other site 743299001644 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 743299001645 PemK-like protein; Region: PemK; pfam02452 743299001646 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 743299001647 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 743299001648 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 743299001649 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 743299001650 active site 743299001651 tetramer interface; other site 743299001652 Protein of unknown function (DUF502); Region: DUF502; cl01107 743299001653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299001654 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743299001655 active site 743299001656 phosphorylation site [posttranslational modification] 743299001657 intermolecular recognition site; other site 743299001658 dimerization interface [polypeptide binding]; other site 743299001659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299001660 Walker A motif; other site 743299001661 ATP binding site [chemical binding]; other site 743299001662 Walker B motif; other site 743299001663 arginine finger; other site 743299001664 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743299001665 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743299001666 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743299001667 dimerization interface [polypeptide binding]; other site 743299001668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299001669 dimer interface [polypeptide binding]; other site 743299001670 phosphorylation site [posttranslational modification] 743299001671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299001672 ATP binding site [chemical binding]; other site 743299001673 Mg2+ binding site [ion binding]; other site 743299001674 G-X-G motif; other site 743299001675 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 743299001676 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 743299001677 Walker A/P-loop; other site 743299001678 ATP binding site [chemical binding]; other site 743299001679 Q-loop/lid; other site 743299001680 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 743299001681 Q-loop/lid; other site 743299001682 ABC transporter signature motif; other site 743299001683 Walker B; other site 743299001684 D-loop; other site 743299001685 H-loop/switch region; other site 743299001686 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 743299001687 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 743299001688 Type III pantothenate kinase; Region: Pan_kinase; cl17198 743299001689 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 743299001690 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 743299001691 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 743299001692 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 743299001693 putative catalytic cysteine [active] 743299001694 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 743299001695 Integrase core domain; Region: rve; pfam00665 743299001696 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 743299001697 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 743299001698 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 743299001699 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743299001700 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743299001701 metal-binding site [ion binding] 743299001702 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743299001703 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743299001704 metal-binding site [ion binding] 743299001705 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743299001706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299001707 active site 743299001708 motif I; other site 743299001709 motif II; other site 743299001710 Domain of unknown function DUF302; Region: DUF302; pfam03625 743299001711 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743299001712 metal-binding site [ion binding] 743299001713 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 743299001714 catalytic residues [active] 743299001715 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 743299001716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 743299001717 Homeodomain-like domain; Region: HTH_23; pfam13384 743299001718 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 743299001719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743299001720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299001721 multiple promoter invertase; Provisional; Region: mpi; PRK13413 743299001722 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 743299001723 catalytic residues [active] 743299001724 catalytic nucleophile [active] 743299001725 Presynaptic Site I dimer interface [polypeptide binding]; other site 743299001726 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 743299001727 Synaptic Flat tetramer interface [polypeptide binding]; other site 743299001728 Synaptic Site I dimer interface [polypeptide binding]; other site 743299001729 DNA binding site [nucleotide binding] 743299001730 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 743299001731 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 743299001732 S-formylglutathione hydrolase; Region: PLN02442 743299001733 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 743299001734 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 743299001735 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 743299001736 substrate binding site [chemical binding]; other site 743299001737 catalytic Zn binding site [ion binding]; other site 743299001738 NAD binding site [chemical binding]; other site 743299001739 structural Zn binding site [ion binding]; other site 743299001740 dimer interface [polypeptide binding]; other site 743299001741 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 743299001742 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 743299001743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299001744 Walker A motif; other site 743299001745 ATP binding site [chemical binding]; other site 743299001746 Walker B motif; other site 743299001747 arginine finger; other site 743299001748 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743299001749 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 743299001750 non-specific DNA binding site [nucleotide binding]; other site 743299001751 salt bridge; other site 743299001752 sequence-specific DNA binding site [nucleotide binding]; other site 743299001753 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 743299001754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743299001755 non-specific DNA binding site [nucleotide binding]; other site 743299001756 salt bridge; other site 743299001757 sequence-specific DNA binding site [nucleotide binding]; other site 743299001758 Domain of unknown function (DUF955); Region: DUF955; pfam06114 743299001759 AntA/AntB antirepressor; Region: AntA; pfam08346 743299001760 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 743299001761 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299001762 Walker A motif; other site 743299001763 ATP binding site [chemical binding]; other site 743299001764 Walker B motif; other site 743299001765 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 743299001766 HipA-like N-terminal domain; Region: HipA_N; pfam07805 743299001767 HipA-like C-terminal domain; Region: HipA_C; pfam07804 743299001768 TIR domain; Region: TIR_2; cl17458 743299001769 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 743299001770 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 743299001771 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 743299001772 active site 743299001773 DNA binding site [nucleotide binding] 743299001774 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 743299001775 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 743299001776 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 743299001777 Catalytic site [active] 743299001778 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 743299001779 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 743299001780 AAA domain; Region: AAA_30; pfam13604 743299001781 Family description; Region: UvrD_C_2; pfam13538 743299001782 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 743299001783 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743299001784 IHF dimer interface [polypeptide binding]; other site 743299001785 IHF - DNA interface [nucleotide binding]; other site 743299001786 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 743299001787 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 743299001788 heme-binding site [chemical binding]; other site 743299001789 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 743299001790 heme-binding site [chemical binding]; other site 743299001791 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299001792 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299001793 metal binding site [ion binding]; metal-binding site 743299001794 active site 743299001795 I-site; other site 743299001796 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299001797 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 743299001798 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 743299001799 Nitrogen regulatory protein P-II; Region: P-II; smart00938 743299001800 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 743299001801 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 743299001802 heme-binding site [chemical binding]; other site 743299001803 RES domain; Region: RES; smart00953 743299001804 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 743299001805 Archaeal ATPase; Region: Arch_ATPase; pfam01637 743299001806 HD domain; Region: HD_3; cl17350 743299001807 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743299001808 IHF - DNA interface [nucleotide binding]; other site 743299001809 IHF dimer interface [polypeptide binding]; other site 743299001810 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 743299001811 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 743299001812 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 743299001813 multiple promoter invertase; Provisional; Region: mpi; PRK13413 743299001814 catalytic residues [active] 743299001815 catalytic nucleophile [active] 743299001816 Presynaptic Site I dimer interface [polypeptide binding]; other site 743299001817 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 743299001818 Synaptic Flat tetramer interface [polypeptide binding]; other site 743299001819 Synaptic Site I dimer interface [polypeptide binding]; other site 743299001820 DNA binding site [nucleotide binding] 743299001821 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 743299001822 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 743299001823 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 743299001824 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 743299001825 Putative zinc-finger; Region: zf-HC2; pfam13490 743299001826 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 743299001827 putative catalytic residues [active] 743299001828 RNA polymerase sigma factor; Provisional; Region: PRK12520 743299001829 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743299001830 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743299001831 DNA binding residues [nucleotide binding] 743299001832 Domain of unknown function DUF302; Region: DUF302; pfam03625 743299001833 Protein of unknown function (DUF421); Region: DUF421; cl00990 743299001834 putative transposase OrfB; Reviewed; Region: PHA02517 743299001835 HTH-like domain; Region: HTH_21; pfam13276 743299001836 Integrase core domain; Region: rve; pfam00665 743299001837 Integrase core domain; Region: rve_3; pfam13683 743299001838 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299001839 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 743299001840 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 743299001841 hypothetical protein; Provisional; Region: PRK05409 743299001842 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 743299001843 Predicted membrane protein [Function unknown]; Region: COG2259 743299001844 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 743299001845 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 743299001846 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 743299001847 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 743299001848 DNA binding residues [nucleotide binding] 743299001849 dimer interface [polypeptide binding]; other site 743299001850 MoxR-like ATPases [General function prediction only]; Region: COG0714 743299001851 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 743299001852 Walker A motif; other site 743299001853 ATP binding site [chemical binding]; other site 743299001854 Walker B motif; other site 743299001855 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 743299001856 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 743299001857 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743299001858 catalytic residues [active] 743299001859 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743299001860 catalytic core [active] 743299001861 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 743299001862 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 743299001863 active site 743299001864 dimer interface [polypeptide binding]; other site 743299001865 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 743299001866 dimer interface [polypeptide binding]; other site 743299001867 active site 743299001868 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 743299001869 putative active site [active] 743299001870 transaldolase; Provisional; Region: PRK03903 743299001871 catalytic residue [active] 743299001872 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743299001873 putative mercuric reductase; Provisional; Region: PRK13748 743299001874 metal-binding site [ion binding] 743299001875 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743299001876 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743299001877 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743299001878 metal-binding site [ion binding] 743299001879 MerT mercuric transport protein; Region: MerT; cl03578 743299001880 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 743299001881 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 743299001882 putative ligand binding site [chemical binding]; other site 743299001883 putative NAD binding site [chemical binding]; other site 743299001884 catalytic site [active] 743299001885 enolase; Provisional; Region: eno; PRK00077 743299001886 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 743299001887 dimer interface [polypeptide binding]; other site 743299001888 metal binding site [ion binding]; metal-binding site 743299001889 substrate binding pocket [chemical binding]; other site 743299001890 pyruvate kinase; Provisional; Region: PRK05826 743299001891 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 743299001892 domain interfaces; other site 743299001893 active site 743299001894 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 743299001895 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 743299001896 putative active site; other site 743299001897 catalytic residue [active] 743299001898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 743299001899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743299001900 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743299001901 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 743299001902 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 743299001903 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743299001904 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 743299001905 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 743299001906 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743299001907 E3 interaction surface; other site 743299001908 lipoyl attachment site [posttranslational modification]; other site 743299001909 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 743299001910 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 743299001911 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 743299001912 alpha subunit interface [polypeptide binding]; other site 743299001913 TPP binding site [chemical binding]; other site 743299001914 heterodimer interface [polypeptide binding]; other site 743299001915 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743299001916 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 743299001917 tetramer interface [polypeptide binding]; other site 743299001918 TPP-binding site [chemical binding]; other site 743299001919 heterodimer interface [polypeptide binding]; other site 743299001920 phosphorylation loop region [posttranslational modification] 743299001921 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 743299001922 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 743299001923 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 743299001924 Phosphoglycerate kinase; Region: PGK; pfam00162 743299001925 substrate binding site [chemical binding]; other site 743299001926 hinge regions; other site 743299001927 ADP binding site [chemical binding]; other site 743299001928 catalytic site [active] 743299001929 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 743299001930 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 743299001931 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 743299001932 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 743299001933 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743299001934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299001935 motif II; other site 743299001936 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 743299001937 Outer membrane efflux protein; Region: OEP; pfam02321 743299001938 Outer membrane efflux protein; Region: OEP; pfam02321 743299001939 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 743299001940 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743299001941 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299001942 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 743299001943 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743299001944 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 743299001945 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 743299001946 Outer membrane efflux protein; Region: OEP; pfam02321 743299001947 Outer membrane efflux protein; Region: OEP; pfam02321 743299001948 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 743299001949 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743299001950 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299001951 motif II; other site 743299001952 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743299001953 putative DNA binding site [nucleotide binding]; other site 743299001954 dimerization interface [polypeptide binding]; other site 743299001955 putative Zn2+ binding site [ion binding]; other site 743299001956 AAA domain; Region: AAA_22; pfam13401 743299001957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 743299001958 Transposase [DNA replication, recombination, and repair]; Region: COG5421 743299001959 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 743299001960 HsdM N-terminal domain; Region: HsdM_N; pfam12161 743299001961 Methyltransferase domain; Region: Methyltransf_26; pfam13659 743299001962 TIGR02646 family protein; Region: TIGR02646 743299001963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299001964 Walker A/P-loop; other site 743299001965 ATP binding site [chemical binding]; other site 743299001966 AAA domain; Region: AAA_21; pfam13304 743299001967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299001968 Q-loop/lid; other site 743299001969 ABC transporter signature motif; other site 743299001970 Walker B; other site 743299001971 D-loop; other site 743299001972 H-loop/switch region; other site 743299001973 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 743299001974 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 743299001975 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 743299001976 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 743299001977 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 743299001978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299001979 ATP binding site [chemical binding]; other site 743299001980 putative Mg++ binding site [ion binding]; other site 743299001981 Divergent AAA domain; Region: AAA_4; pfam04326 743299001982 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 743299001983 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 743299001984 DNA binding domain, excisionase family; Region: excise; TIGR01764 743299001985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299001986 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743299001987 putative substrate translocation pore; other site 743299001988 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 743299001989 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 743299001990 Lipopolysaccharide-assembly; Region: LptE; cl01125 743299001991 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 743299001992 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 743299001993 HIGH motif; other site 743299001994 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 743299001995 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743299001996 active site 743299001997 KMSKS motif; other site 743299001998 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 743299001999 tRNA binding surface [nucleotide binding]; other site 743299002000 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 743299002001 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 743299002002 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 743299002003 MarR family; Region: MarR_2; pfam12802 743299002004 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 743299002005 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 743299002006 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 743299002007 Sulfate transporter family; Region: Sulfate_transp; pfam00916 743299002008 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 743299002009 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 743299002010 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 743299002011 DNA binding site [nucleotide binding] 743299002012 H2TH interface [polypeptide binding]; other site 743299002013 putative catalytic residues [active] 743299002014 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 743299002015 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 743299002016 active site residue [active] 743299002017 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 743299002018 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 743299002019 glutamine synthetase; Provisional; Region: glnA; PRK09469 743299002020 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 743299002021 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743299002022 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743299002023 Protein of unknown function (DUF421); Region: DUF421; cl00990 743299002024 putative transposase OrfB; Reviewed; Region: PHA02517 743299002025 HTH-like domain; Region: HTH_21; pfam13276 743299002026 Integrase core domain; Region: rve; pfam00665 743299002027 Integrase core domain; Region: rve_3; pfam13683 743299002028 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 743299002029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299002030 S-adenosylmethionine binding site [chemical binding]; other site 743299002031 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 743299002032 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 743299002033 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743299002034 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 743299002035 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743299002036 DNA binding residues [nucleotide binding] 743299002037 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 743299002038 aminotransferase; Validated; Region: PRK08175 743299002039 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743299002040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299002041 homodimer interface [polypeptide binding]; other site 743299002042 catalytic residue [active] 743299002043 homoserine dehydrogenase; Provisional; Region: PRK06349 743299002044 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 743299002045 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 743299002046 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 743299002047 threonine synthase; Reviewed; Region: PRK06721 743299002048 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 743299002049 homodimer interface [polypeptide binding]; other site 743299002050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299002051 catalytic residue [active] 743299002052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 743299002053 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743299002054 active site 743299002055 DNA binding site [nucleotide binding] 743299002056 Int/Topo IB signature motif; other site 743299002057 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 743299002058 DHH family; Region: DHH; pfam01368 743299002059 Flagellin N-methylase; Region: FliB; pfam03692 743299002060 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 743299002061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743299002062 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 743299002063 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 743299002064 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 743299002065 DEAD-like helicases superfamily; Region: DEXDc; smart00487 743299002066 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299002067 ATP binding site [chemical binding]; other site 743299002068 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 743299002069 putative Mg++ binding site [ion binding]; other site 743299002070 T5orf172 domain; Region: T5orf172; pfam10544 743299002071 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 743299002072 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 743299002073 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743299002074 catalytic residue [active] 743299002075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 743299002076 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 743299002077 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743299002078 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299002079 motif II; other site 743299002080 Outer membrane efflux protein; Region: OEP; pfam02321 743299002081 Outer membrane efflux protein; Region: OEP; pfam02321 743299002082 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 743299002083 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743299002084 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299002085 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 743299002086 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743299002087 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 743299002088 AAA domain; Region: AAA_21; pfam13304 743299002089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299002090 Walker A/P-loop; other site 743299002091 ATP binding site [chemical binding]; other site 743299002092 RloB-like protein; Region: RloB; pfam13707 743299002093 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743299002094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299002095 Walker A motif; other site 743299002096 ATP binding site [chemical binding]; other site 743299002097 Walker B motif; other site 743299002098 arginine finger; other site 743299002099 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 743299002100 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 743299002101 putative active site [active] 743299002102 GAF domain; Region: GAF_2; pfam13185 743299002103 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299002104 metal binding site [ion binding]; metal-binding site 743299002105 active site 743299002106 I-site; other site 743299002107 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299002108 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 743299002109 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 743299002110 DXD motif; other site 743299002111 PilZ domain; Region: PilZ; pfam07238 743299002112 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 743299002113 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299002114 Transposase; Region: DEDD_Tnp_IS110; pfam01548 743299002115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 743299002116 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 743299002117 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 743299002118 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 743299002119 V4R domain; Region: V4R; cl15268 743299002120 peptide chain release factor 2; Validated; Region: prfB; PRK00578 743299002121 This domain is found in peptide chain release factors; Region: PCRF; smart00937 743299002122 RF-1 domain; Region: RF-1; pfam00472 743299002123 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 743299002124 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 743299002125 dimer interface [polypeptide binding]; other site 743299002126 putative anticodon binding site; other site 743299002127 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 743299002128 motif 1; other site 743299002129 active site 743299002130 motif 2; other site 743299002131 motif 3; other site 743299002132 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 743299002133 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743299002134 FtsX-like permease family; Region: FtsX; pfam02687 743299002135 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 743299002136 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 743299002137 Walker A/P-loop; other site 743299002138 ATP binding site [chemical binding]; other site 743299002139 Q-loop/lid; other site 743299002140 ABC transporter signature motif; other site 743299002141 Walker B; other site 743299002142 D-loop; other site 743299002143 H-loop/switch region; other site 743299002144 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 743299002145 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 743299002146 Competence protein; Region: Competence; pfam03772 743299002147 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 743299002148 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743299002149 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 743299002150 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 743299002151 putative acyl-acceptor binding pocket; other site 743299002152 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 743299002153 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 743299002154 Uncharacterized conserved protein [Function unknown]; Region: COG2835 743299002155 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 743299002156 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 743299002157 Ligand binding site; other site 743299002158 oligomer interface; other site 743299002159 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 743299002160 dimer interface [polypeptide binding]; other site 743299002161 substrate binding site [chemical binding]; other site 743299002162 metal binding sites [ion binding]; metal-binding site 743299002163 YcfA-like protein; Region: YcfA; pfam07927 743299002164 DinB family; Region: DinB; cl17821 743299002165 DinB superfamily; Region: DinB_2; pfam12867 743299002166 Transposase; Region: HTH_Tnp_1; cl17663 743299002167 Winged helix-turn helix; Region: HTH_29; pfam13551 743299002168 Homeodomain-like domain; Region: HTH_32; pfam13565 743299002169 Integrase core domain; Region: rve; pfam00665 743299002170 Integrase core domain; Region: rve_3; pfam13683 743299002171 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 743299002172 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 743299002173 putative active site [active] 743299002174 putative NTP binding site [chemical binding]; other site 743299002175 putative nucleic acid binding site [nucleotide binding]; other site 743299002176 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 743299002177 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 743299002178 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 743299002179 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 743299002180 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 743299002181 putative uracil binding site [chemical binding]; other site 743299002182 putative active site [active] 743299002183 Uncharacterized conserved protein [Function unknown]; Region: COG0397 743299002184 hypothetical protein; Validated; Region: PRK00029 743299002185 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 743299002186 Clp amino terminal domain; Region: Clp_N; pfam02861 743299002187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299002188 Walker A motif; other site 743299002189 ATP binding site [chemical binding]; other site 743299002190 Walker B motif; other site 743299002191 arginine finger; other site 743299002192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299002193 Walker A motif; other site 743299002194 ATP binding site [chemical binding]; other site 743299002195 Walker B motif; other site 743299002196 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 743299002197 Uncharacterized conserved protein [Function unknown]; Region: COG2127 743299002198 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 743299002199 DJ-1 family protein; Region: not_thiJ; TIGR01383 743299002200 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 743299002201 conserved cys residue [active] 743299002202 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 743299002203 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 743299002204 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 743299002205 protein binding site [polypeptide binding]; other site 743299002206 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 743299002207 Catalytic dyad [active] 743299002208 Peptidase family M23; Region: Peptidase_M23; pfam01551 743299002209 phosphoglyceromutase; Provisional; Region: PRK05434 743299002210 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 743299002211 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 743299002212 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 743299002213 homodimer interface [polypeptide binding]; other site 743299002214 active site pocket [active] 743299002215 Protein required for attachment to host cells; Region: Host_attach; pfam10116 743299002216 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 743299002217 active site residue [active] 743299002218 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 743299002219 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 743299002220 substrate binding site [chemical binding]; other site 743299002221 ATP binding site [chemical binding]; other site 743299002222 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 743299002223 S-adenosylmethionine synthetase; Validated; Region: PRK05250 743299002224 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 743299002225 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 743299002226 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 743299002227 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 743299002228 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 743299002229 homotetramer interface [polypeptide binding]; other site 743299002230 ligand binding site [chemical binding]; other site 743299002231 catalytic site [active] 743299002232 NAD binding site [chemical binding]; other site 743299002233 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 743299002234 FAD binding site [chemical binding]; other site 743299002235 phosphoribulokinase; Provisional; Region: PRK15453 743299002236 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 743299002237 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 743299002238 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 743299002239 helicase 45; Provisional; Region: PTZ00424 743299002240 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743299002241 ATP binding site [chemical binding]; other site 743299002242 Mg++ binding site [ion binding]; other site 743299002243 motif III; other site 743299002244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743299002245 nucleotide binding region [chemical binding]; other site 743299002246 ATP-binding site [chemical binding]; other site 743299002247 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 743299002248 putative RNA binding site [nucleotide binding]; other site 743299002249 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 743299002250 DNA-binding site [nucleotide binding]; DNA binding site 743299002251 RNA-binding motif; other site 743299002252 primosome assembly protein PriA; Validated; Region: PRK05580 743299002253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299002254 ATP binding site [chemical binding]; other site 743299002255 putative Mg++ binding site [ion binding]; other site 743299002256 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 743299002257 UbiA prenyltransferase family; Region: UbiA; pfam01040 743299002258 Chorismate lyase; Region: Chor_lyase; cl01230 743299002259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743299002260 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 743299002261 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 743299002262 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299002263 FeS/SAM binding site; other site 743299002264 TRAM domain; Region: TRAM; cl01282 743299002265 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 743299002266 PhoH-like protein; Region: PhoH; pfam02562 743299002267 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 743299002268 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 743299002269 Pleckstrin homology-like domain; Region: PH-like; cl17171 743299002270 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 743299002271 Transporter associated domain; Region: CorC_HlyC; smart01091 743299002272 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 743299002273 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 743299002274 putative active site [active] 743299002275 catalytic triad [active] 743299002276 putative dimer interface [polypeptide binding]; other site 743299002277 peptidase PmbA; Provisional; Region: PRK11040 743299002278 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743299002279 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 743299002280 intersubunit interface [polypeptide binding]; other site 743299002281 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 743299002282 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 743299002283 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 743299002284 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 743299002285 ABC-ATPase subunit interface; other site 743299002286 dimer interface [polypeptide binding]; other site 743299002287 putative PBP binding regions; other site 743299002288 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 743299002289 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 743299002290 putative PBP binding regions; other site 743299002291 ABC-ATPase subunit interface; other site 743299002292 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743299002293 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 743299002294 putative NAD(P) binding site [chemical binding]; other site 743299002295 active site 743299002296 putative substrate binding site [chemical binding]; other site 743299002297 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 743299002298 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 743299002299 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 743299002300 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 743299002301 putative ADP-binding pocket [chemical binding]; other site 743299002302 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 743299002303 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 743299002304 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 743299002305 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743299002306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299002307 Walker A/P-loop; other site 743299002308 ATP binding site [chemical binding]; other site 743299002309 Q-loop/lid; other site 743299002310 ABC transporter signature motif; other site 743299002311 Walker B; other site 743299002312 D-loop; other site 743299002313 H-loop/switch region; other site 743299002314 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 743299002315 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 743299002316 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 743299002317 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 743299002318 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743299002319 catalytic core [active] 743299002320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743299002321 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 743299002322 non-specific DNA binding site [nucleotide binding]; other site 743299002323 salt bridge; other site 743299002324 sequence-specific DNA binding site [nucleotide binding]; other site 743299002325 Methyltransferase domain; Region: Methyltransf_31; pfam13847 743299002326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299002327 S-adenosylmethionine binding site [chemical binding]; other site 743299002328 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 743299002329 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 743299002330 substrate binding site [chemical binding]; other site 743299002331 ligand binding site [chemical binding]; other site 743299002332 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 743299002333 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 743299002334 substrate binding site [chemical binding]; other site 743299002335 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 743299002336 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 743299002337 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 743299002338 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 743299002339 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 743299002340 potential catalytic triad [active] 743299002341 conserved cys residue [active] 743299002342 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 743299002343 tetramer (dimer of dimers) interface [polypeptide binding]; other site 743299002344 active site 743299002345 dimer interface [polypeptide binding]; other site 743299002346 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 743299002347 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 743299002348 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 743299002349 cytochrome o ubiquinol oxidase, subunit I; Region: CyoB; TIGR02843 743299002350 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 743299002351 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 743299002352 Subunit I/III interface [polypeptide binding]; other site 743299002353 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 743299002354 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 743299002355 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 743299002356 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 743299002357 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 743299002358 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743299002359 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 743299002360 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743299002361 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 743299002362 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 743299002363 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743299002364 ATP-grasp domain; Region: ATP-grasp_4; cl17255 743299002365 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 743299002366 IMP binding site; other site 743299002367 dimer interface [polypeptide binding]; other site 743299002368 partial ornithine binding site; other site 743299002369 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 743299002370 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 743299002371 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 743299002372 catalytic site [active] 743299002373 subunit interface [polypeptide binding]; other site 743299002374 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 743299002375 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 743299002376 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 743299002377 cytochrome o ubiquinol oxidase, subunit I; Region: CyoB; TIGR02843 743299002378 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 743299002379 Subunit I/III interface [polypeptide binding]; other site 743299002380 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 743299002381 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 743299002382 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299002383 integrase; Provisional; Region: PRK09692 743299002384 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 743299002385 active site 743299002386 Int/Topo IB signature motif; other site 743299002387 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 743299002388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743299002389 salt bridge; other site 743299002390 non-specific DNA binding site [nucleotide binding]; other site 743299002391 sequence-specific DNA binding site [nucleotide binding]; other site 743299002392 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 743299002393 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 743299002394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299002395 Walker A motif; other site 743299002396 ATP binding site [chemical binding]; other site 743299002397 Walker B motif; other site 743299002398 Integrase core domain; Region: rve; pfam00665 743299002399 multiple promoter invertase; Provisional; Region: mpi; PRK13413 743299002400 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 743299002401 catalytic residues [active] 743299002402 catalytic nucleophile [active] 743299002403 Presynaptic Site I dimer interface [polypeptide binding]; other site 743299002404 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 743299002405 Synaptic Flat tetramer interface [polypeptide binding]; other site 743299002406 Synaptic Site I dimer interface [polypeptide binding]; other site 743299002407 DNA binding site [nucleotide binding] 743299002408 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 743299002409 DNA-binding interface [nucleotide binding]; DNA binding site 743299002410 YtxH-like protein; Region: YtxH; cl02079 743299002411 phosphoglucomutase; Region: PLN02307 743299002412 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 743299002413 substrate binding site [chemical binding]; other site 743299002414 dimer interface [polypeptide binding]; other site 743299002415 active site 743299002416 metal binding site [ion binding]; metal-binding site 743299002417 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 743299002418 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 743299002419 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 743299002420 putative NAD(P) binding site [chemical binding]; other site 743299002421 active site 743299002422 putative substrate binding site [chemical binding]; other site 743299002423 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 743299002424 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 743299002425 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 743299002426 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 743299002427 catalytic site [active] 743299002428 putative active site [active] 743299002429 putative substrate binding site [chemical binding]; other site 743299002430 dimer interface [polypeptide binding]; other site 743299002431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743299002432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299002433 active site 743299002434 phosphorylation site [posttranslational modification] 743299002435 intermolecular recognition site; other site 743299002436 dimerization interface [polypeptide binding]; other site 743299002437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743299002438 DNA binding site [nucleotide binding] 743299002439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743299002440 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743299002441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299002442 dimer interface [polypeptide binding]; other site 743299002443 phosphorylation site [posttranslational modification] 743299002444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299002445 ATP binding site [chemical binding]; other site 743299002446 Mg2+ binding site [ion binding]; other site 743299002447 G-X-G motif; other site 743299002448 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 743299002449 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 743299002450 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743299002451 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 743299002452 TolA protein; Region: tolA_full; TIGR02794 743299002453 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743299002454 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 743299002455 Phosphoesterase family; Region: Phosphoesterase; pfam04185 743299002456 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 743299002457 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 743299002458 quinone interaction residues [chemical binding]; other site 743299002459 active site 743299002460 catalytic residues [active] 743299002461 FMN binding site [chemical binding]; other site 743299002462 substrate binding site [chemical binding]; other site 743299002463 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 743299002464 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 743299002465 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 743299002466 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 743299002467 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 743299002468 ATP-grasp domain; Region: ATP-grasp_4; cl17255 743299002469 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 743299002470 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 743299002471 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 743299002472 purine monophosphate binding site [chemical binding]; other site 743299002473 dimer interface [polypeptide binding]; other site 743299002474 putative catalytic residues [active] 743299002475 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 743299002476 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 743299002477 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 743299002478 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 743299002479 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 743299002480 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 743299002481 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 743299002482 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743299002483 Soluble P-type ATPase [General function prediction only]; Region: COG4087 743299002484 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 743299002485 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 743299002486 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 743299002487 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 743299002488 Ligand Binding Site [chemical binding]; other site 743299002489 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 743299002490 GAF domain; Region: GAF_3; pfam13492 743299002491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299002492 dimer interface [polypeptide binding]; other site 743299002493 phosphorylation site [posttranslational modification] 743299002494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299002495 ATP binding site [chemical binding]; other site 743299002496 Mg2+ binding site [ion binding]; other site 743299002497 G-X-G motif; other site 743299002498 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743299002499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299002500 active site 743299002501 phosphorylation site [posttranslational modification] 743299002502 intermolecular recognition site; other site 743299002503 dimerization interface [polypeptide binding]; other site 743299002504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743299002505 DNA binding site [nucleotide binding] 743299002506 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 743299002507 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299002508 motif II; other site 743299002509 Phosphotransferase enzyme family; Region: APH; pfam01636 743299002510 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 743299002511 active site 743299002512 ATP binding site [chemical binding]; other site 743299002513 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 743299002514 substrate binding site [chemical binding]; other site 743299002515 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 743299002516 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299002517 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299002518 metal binding site [ion binding]; metal-binding site 743299002519 active site 743299002520 I-site; other site 743299002521 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299002522 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 743299002523 Transglycosylase; Region: Transgly; pfam00912 743299002524 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 743299002525 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 743299002526 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 743299002527 active site 743299002528 HIGH motif; other site 743299002529 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 743299002530 active site 743299002531 KMSKS motif; other site 743299002532 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 743299002533 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 743299002534 active site 743299002535 HIGH motif; other site 743299002536 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 743299002537 KMSKS motif; other site 743299002538 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 743299002539 tRNA binding surface [nucleotide binding]; other site 743299002540 anticodon binding site; other site 743299002541 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 743299002542 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 743299002543 homodimer interface [polypeptide binding]; other site 743299002544 oligonucleotide binding site [chemical binding]; other site 743299002545 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 743299002546 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743299002547 RNA binding surface [nucleotide binding]; other site 743299002548 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 743299002549 active site 743299002550 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 743299002551 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 743299002552 active site 743299002553 dimerization interface [polypeptide binding]; other site 743299002554 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 743299002555 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 743299002556 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 743299002557 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 743299002558 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 743299002559 trimer interface [polypeptide binding]; other site 743299002560 active site 743299002561 substrate binding site [chemical binding]; other site 743299002562 CoA binding site [chemical binding]; other site 743299002563 Predicted transcriptional regulator [Transcription]; Region: COG1959 743299002564 Transcriptional regulator; Region: Rrf2; cl17282 743299002565 cysteine desulfurase; Provisional; Region: PRK14012 743299002566 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 743299002567 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743299002568 catalytic residue [active] 743299002569 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 743299002570 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 743299002571 trimerization site [polypeptide binding]; other site 743299002572 active site 743299002573 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 743299002574 DnaJ domain; Region: DnaJ; pfam00226 743299002575 co-chaperone HscB; Provisional; Region: hscB; PRK03578 743299002576 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 743299002577 chaperone protein HscA; Provisional; Region: hscA; PRK05183 743299002578 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 743299002579 nucleotide binding site [chemical binding]; other site 743299002580 putative NEF/HSP70 interaction site [polypeptide binding]; other site 743299002581 SBD interface [polypeptide binding]; other site 743299002582 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 743299002583 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743299002584 catalytic loop [active] 743299002585 iron binding site [ion binding]; other site 743299002586 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 743299002587 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 743299002588 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 743299002589 Ligand Binding Site [chemical binding]; other site 743299002590 hypothetical protein; Provisional; Region: PRK10279 743299002591 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 743299002592 active site 743299002593 nucleophile elbow; other site 743299002594 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 743299002595 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 743299002596 putative active site [active] 743299002597 homotetrameric interface [polypeptide binding]; other site 743299002598 metal binding site [ion binding]; metal-binding site 743299002599 HsdM N-terminal domain; Region: HsdM_N; pfam12161 743299002600 S-formylglutathione hydrolase; Region: PLN02442 743299002601 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 743299002602 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 743299002603 thiS-thiF/thiG interaction site; other site 743299002604 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 743299002605 ThiS interaction site; other site 743299002606 putative active site [active] 743299002607 tetramer interface [polypeptide binding]; other site 743299002608 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 743299002609 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743299002610 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743299002611 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743299002612 aromatic acid decarboxylase; Validated; Region: PRK05920 743299002613 Flavoprotein; Region: Flavoprotein; pfam02441 743299002614 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 743299002615 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 743299002616 Walker A/P-loop; other site 743299002617 ATP binding site [chemical binding]; other site 743299002618 Q-loop/lid; other site 743299002619 ABC transporter signature motif; other site 743299002620 Walker B; other site 743299002621 D-loop; other site 743299002622 H-loop/switch region; other site 743299002623 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 743299002624 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 743299002625 Permease; Region: Permease; pfam02405 743299002626 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 743299002627 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 743299002628 putative catalytic site [active] 743299002629 putative metal binding site [ion binding]; other site 743299002630 putative phosphate binding site [ion binding]; other site 743299002631 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 743299002632 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 743299002633 ATP binding site [chemical binding]; other site 743299002634 substrate interface [chemical binding]; other site 743299002635 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 743299002636 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 743299002637 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 743299002638 Walker A/P-loop; other site 743299002639 ATP binding site [chemical binding]; other site 743299002640 Q-loop/lid; other site 743299002641 ABC transporter signature motif; other site 743299002642 Walker B; other site 743299002643 D-loop; other site 743299002644 H-loop/switch region; other site 743299002645 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743299002646 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743299002647 catalytic residues [active] 743299002648 transcription termination factor Rho; Provisional; Region: rho; PRK09376 743299002649 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 743299002650 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 743299002651 RNA binding site [nucleotide binding]; other site 743299002652 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 743299002653 multimer interface [polypeptide binding]; other site 743299002654 Walker A motif; other site 743299002655 ATP binding site [chemical binding]; other site 743299002656 Walker B motif; other site 743299002657 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 743299002658 Malic enzyme, N-terminal domain; Region: malic; pfam00390 743299002659 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 743299002660 NAD(P) binding pocket [chemical binding]; other site 743299002661 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 743299002662 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 743299002663 6-phosphogluconate dehydratase; Region: edd; TIGR01196 743299002664 LabA_like proteins; Region: LabA; cd10911 743299002665 Uncharacterized conserved protein [Function unknown]; Region: COG1432 743299002666 putative metal binding site [ion binding]; other site 743299002667 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743299002668 RNA binding site [nucleotide binding]; other site 743299002669 N-acetylglutamate synthase; Validated; Region: PRK05279 743299002670 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 743299002671 putative feedback inhibition sensing region; other site 743299002672 putative nucleotide binding site [chemical binding]; other site 743299002673 putative substrate binding site [chemical binding]; other site 743299002674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743299002675 Coenzyme A binding pocket [chemical binding]; other site 743299002676 BolA-like protein; Region: BolA; pfam01722 743299002677 YciI-like protein; Reviewed; Region: PRK11370 743299002678 intracellular septation protein A; Reviewed; Region: PRK00259 743299002679 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 743299002680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299002681 Walker A motif; other site 743299002682 ATP binding site [chemical binding]; other site 743299002683 Walker B motif; other site 743299002684 arginine finger; other site 743299002685 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 743299002686 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 743299002687 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 743299002688 active site 743299002689 NTP binding site [chemical binding]; other site 743299002690 metal binding triad [ion binding]; metal-binding site 743299002691 antibiotic binding site [chemical binding]; other site 743299002692 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 743299002693 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 743299002694 HicB family; Region: HicB; pfam05534 743299002695 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 743299002696 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 743299002697 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 743299002698 oligomeric interface; other site 743299002699 putative active site [active] 743299002700 homodimer interface [polypeptide binding]; other site 743299002701 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 743299002702 AAA domain; Region: AAA_14; pfam13173 743299002703 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 743299002704 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 743299002705 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 743299002706 Substrate binding site; other site 743299002707 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 743299002708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 743299002709 Uncharacterized conserved protein [Function unknown]; Region: COG2442 743299002710 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 743299002711 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 743299002712 NADP-binding site; other site 743299002713 homotetramer interface [polypeptide binding]; other site 743299002714 substrate binding site [chemical binding]; other site 743299002715 homodimer interface [polypeptide binding]; other site 743299002716 active site 743299002717 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743299002718 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 743299002719 homotetramer interface [polypeptide binding]; other site 743299002720 NADP-binding site; other site 743299002721 substrate binding site [chemical binding]; other site 743299002722 homodimer interface [polypeptide binding]; other site 743299002723 active site 743299002724 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 743299002725 putative active site [active] 743299002726 homotetrameric interface [polypeptide binding]; other site 743299002727 metal binding site [ion binding]; metal-binding site 743299002728 potential frameshift: common BLAST hit: gi|339483010|ref|YP_004694796.1| transposase IS4 family protein 743299002729 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 743299002730 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 743299002731 Bacterial sugar transferase; Region: Bac_transf; pfam02397 743299002732 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 743299002733 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743299002734 active site 743299002735 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743299002736 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 743299002737 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743299002738 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743299002739 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 743299002740 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 743299002741 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743299002742 active site 743299002743 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 743299002744 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 743299002745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299002746 NAD(P) binding site [chemical binding]; other site 743299002747 active site 743299002748 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 743299002749 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 743299002750 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 743299002751 inhibitor-cofactor binding pocket; inhibition site 743299002752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299002753 catalytic residue [active] 743299002754 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 743299002755 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 743299002756 NAD binding site [chemical binding]; other site 743299002757 homotetramer interface [polypeptide binding]; other site 743299002758 homodimer interface [polypeptide binding]; other site 743299002759 substrate binding site [chemical binding]; other site 743299002760 active site 743299002761 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 743299002762 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 743299002763 substrate binding site; other site 743299002764 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 743299002765 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 743299002766 NAD binding site [chemical binding]; other site 743299002767 homodimer interface [polypeptide binding]; other site 743299002768 active site 743299002769 substrate binding site [chemical binding]; other site 743299002770 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 743299002771 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 743299002772 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 743299002773 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 743299002774 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743299002775 Magnesium ion binding site [ion binding]; other site 743299002776 polysaccharide export protein Wza; Provisional; Region: PRK15078 743299002777 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 743299002778 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 743299002779 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 743299002780 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 743299002781 active site 743299002782 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 743299002783 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 743299002784 PemK-like protein; Region: PemK; cl00995 743299002785 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 743299002786 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 743299002787 putative active site [active] 743299002788 homotetrameric interface [polypeptide binding]; other site 743299002789 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 743299002790 DDE superfamily endonuclease; Region: DDE_3; pfam13358 743299002791 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 743299002792 Bacterial sugar transferase; Region: Bac_transf; pfam02397 743299002793 Protein of unknown function DUF86; Region: DUF86; cl01031 743299002794 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 743299002795 Predicted transcriptional regulator [Transcription]; Region: COG3905 743299002796 putative oxidoreductase; Provisional; Region: PRK13984 743299002797 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 743299002798 Transposase; Region: DDE_Tnp_ISL3; pfam01610 743299002799 RelB antitoxin; Region: RelB; cl01171 743299002800 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 743299002801 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 743299002802 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 743299002803 active site 743299002804 FMN binding site [chemical binding]; other site 743299002805 substrate binding site [chemical binding]; other site 743299002806 homotetramer interface [polypeptide binding]; other site 743299002807 catalytic residue [active] 743299002808 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 743299002809 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743299002810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743299002811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743299002812 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 743299002813 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 743299002814 dimerization interface [polypeptide binding]; other site 743299002815 active site 743299002816 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 743299002817 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 743299002818 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743299002819 active site 743299002820 HIGH motif; other site 743299002821 nucleotide binding site [chemical binding]; other site 743299002822 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 743299002823 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 743299002824 active site 743299002825 KMSKS motif; other site 743299002826 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 743299002827 tRNA binding surface [nucleotide binding]; other site 743299002828 anticodon binding site; other site 743299002829 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 743299002830 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 743299002831 multifunctional aminopeptidase A; Provisional; Region: PRK00913 743299002832 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 743299002833 interface (dimer of trimers) [polypeptide binding]; other site 743299002834 Substrate-binding/catalytic site; other site 743299002835 Zn-binding sites [ion binding]; other site 743299002836 Predicted permeases [General function prediction only]; Region: COG0795 743299002837 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 743299002838 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 743299002839 Predicted permeases [General function prediction only]; Region: COG0795 743299002840 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299002841 Glutaredoxin, GrxB family; Region: GRXB; TIGR02182 743299002842 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 743299002843 N-terminal domain interface [polypeptide binding]; other site 743299002844 EVE domain; Region: EVE; cl00728 743299002845 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cl00238 743299002846 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 743299002847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299002848 ATP binding site [chemical binding]; other site 743299002849 putative Mg++ binding site [ion binding]; other site 743299002850 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743299002851 nucleotide binding region [chemical binding]; other site 743299002852 ATP-binding site [chemical binding]; other site 743299002853 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 743299002854 HRDC domain; Region: HRDC; pfam00570 743299002855 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 743299002856 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 743299002857 active site 743299002858 metal binding site [ion binding]; metal-binding site 743299002859 DsrE/DsrF-like family; Region: DrsE; cl00672 743299002860 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 743299002861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743299002862 dimer interface [polypeptide binding]; other site 743299002863 conserved gate region; other site 743299002864 putative PBP binding loops; other site 743299002865 ABC-ATPase subunit interface; other site 743299002866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299002867 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 743299002868 Walker A/P-loop; other site 743299002869 ATP binding site [chemical binding]; other site 743299002870 Q-loop/lid; other site 743299002871 ABC transporter signature motif; other site 743299002872 Walker B; other site 743299002873 D-loop; other site 743299002874 H-loop/switch region; other site 743299002875 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 743299002876 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 743299002877 Part of AAA domain; Region: AAA_19; pfam13245 743299002878 Family description; Region: UvrD_C_2; pfam13538 743299002879 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 743299002880 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 743299002881 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 743299002882 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 743299002883 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743299002884 RNA binding surface [nucleotide binding]; other site 743299002885 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 743299002886 active site 743299002887 uracil binding [chemical binding]; other site 743299002888 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 743299002889 nudix motif; other site 743299002890 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 743299002891 putative active site [active] 743299002892 Ap4A binding site [chemical binding]; other site 743299002893 nudix motif; other site 743299002894 putative metal binding site [ion binding]; other site 743299002895 Cna protein B-type domain; Region: Cna_B_2; pfam13715 743299002896 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 743299002897 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 743299002898 putative active site [active] 743299002899 putative metal binding site [ion binding]; other site 743299002900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299002901 S-adenosylmethionine binding site [chemical binding]; other site 743299002902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743299002903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743299002904 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 743299002905 putative dimerization interface [polypeptide binding]; other site 743299002906 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 743299002907 metal ion-dependent adhesion site (MIDAS); other site 743299002908 MoxR-like ATPases [General function prediction only]; Region: COG0714 743299002909 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 743299002910 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 743299002911 ribulose bisphosphate carboxylase; Provisional; Region: PRK13475 743299002912 Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211 743299002913 dimer interface [polypeptide binding]; other site 743299002914 active site 743299002915 catalytic residue [active] 743299002916 metal binding site [ion binding]; metal-binding site 743299002917 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 743299002918 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 743299002919 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 743299002920 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 743299002921 hydrogenase 4 subunit F; Validated; Region: PRK06458 743299002922 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743299002923 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 743299002924 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 743299002925 hydrogenase 4 subunit B; Validated; Region: PRK06521 743299002926 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743299002927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743299002928 non-specific DNA binding site [nucleotide binding]; other site 743299002929 salt bridge; other site 743299002930 sequence-specific DNA binding site [nucleotide binding]; other site 743299002931 Cupin domain; Region: Cupin_2; pfam07883 743299002932 GTP-binding protein YchF; Reviewed; Region: PRK09601 743299002933 YchF GTPase; Region: YchF; cd01900 743299002934 G1 box; other site 743299002935 GTP/Mg2+ binding site [chemical binding]; other site 743299002936 Switch I region; other site 743299002937 G2 box; other site 743299002938 Switch II region; other site 743299002939 G3 box; other site 743299002940 G4 box; other site 743299002941 G5 box; other site 743299002942 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 743299002943 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 743299002944 putative active site [active] 743299002945 catalytic residue [active] 743299002946 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 743299002947 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 743299002948 5S rRNA interface [nucleotide binding]; other site 743299002949 CTC domain interface [polypeptide binding]; other site 743299002950 L16 interface [polypeptide binding]; other site 743299002951 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 743299002952 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 743299002953 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 743299002954 Cell division protein ZapA; Region: ZapA; pfam05164 743299002955 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 743299002956 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 743299002957 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 743299002958 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 743299002959 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 743299002960 protein binding site [polypeptide binding]; other site 743299002961 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 743299002962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299002963 S-adenosylmethionine binding site [chemical binding]; other site 743299002964 mce related protein; Region: MCE; pfam02470 743299002965 Protein of unknown function (DUF330); Region: DUF330; cl01135 743299002966 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743299002967 Ligand Binding Site [chemical binding]; other site 743299002968 prolyl-tRNA synthetase; Provisional; Region: PRK09194 743299002969 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 743299002970 dimer interface [polypeptide binding]; other site 743299002971 motif 1; other site 743299002972 active site 743299002973 motif 2; other site 743299002974 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 743299002975 putative deacylase active site [active] 743299002976 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 743299002977 active site 743299002978 motif 3; other site 743299002979 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 743299002980 anticodon binding site; other site 743299002981 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 743299002982 preprotein translocase subunit SecB; Validated; Region: PRK05751 743299002983 SecA binding site; other site 743299002984 Preprotein binding site; other site 743299002985 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 743299002986 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 743299002987 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 743299002988 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 743299002989 active site lid residues [active] 743299002990 substrate binding pocket [chemical binding]; other site 743299002991 catalytic residues [active] 743299002992 substrate-Mg2+ binding site; other site 743299002993 aspartate-rich region 1; other site 743299002994 aspartate-rich region 2; other site 743299002995 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 743299002996 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 743299002997 Active site cavity [active] 743299002998 catalytic acid [active] 743299002999 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 743299003000 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 743299003001 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 743299003002 putative NADP binding site [chemical binding]; other site 743299003003 putative substrate binding site [chemical binding]; other site 743299003004 active site 743299003005 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 743299003006 ligand binding site; other site 743299003007 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 743299003008 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 743299003009 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 743299003010 B12 binding site [chemical binding]; other site 743299003011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 743299003012 FeS/SAM binding site; other site 743299003013 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 743299003014 putative active site [active] 743299003015 YdjC motif; other site 743299003016 Mg binding site [ion binding]; other site 743299003017 putative homodimer interface [polypeptide binding]; other site 743299003018 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 743299003019 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 743299003020 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 743299003021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299003022 FeS/SAM binding site; other site 743299003023 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 743299003024 hopanoid biosynthesis associated membrane protein HpnM; Region: HpnM; TIGR03481 743299003025 VacJ like lipoprotein; Region: VacJ; cl01073 743299003026 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 743299003027 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 743299003028 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 743299003029 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 743299003030 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 743299003031 GatB domain; Region: GatB_Yqey; smart00845 743299003032 SCP-2 sterol transfer family; Region: SCP2; cl01225 743299003033 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743299003034 DEAD-like helicases superfamily; Region: DEXDc; smart00487 743299003035 ATP binding site [chemical binding]; other site 743299003036 Mg++ binding site [ion binding]; other site 743299003037 motif III; other site 743299003038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743299003039 nucleotide binding region [chemical binding]; other site 743299003040 ATP-binding site [chemical binding]; other site 743299003041 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 743299003042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299003043 active site 743299003044 phosphorylation site [posttranslational modification] 743299003045 intermolecular recognition site; other site 743299003046 dimerization interface [polypeptide binding]; other site 743299003047 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743299003048 DNA binding site [nucleotide binding] 743299003049 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 743299003050 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743299003051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743299003052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299003053 dimer interface [polypeptide binding]; other site 743299003054 phosphorylation site [posttranslational modification] 743299003055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299003056 ATP binding site [chemical binding]; other site 743299003057 Mg2+ binding site [ion binding]; other site 743299003058 G-X-G motif; other site 743299003059 PBP superfamily domain; Region: PBP_like_2; cl17296 743299003060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743299003061 dimer interface [polypeptide binding]; other site 743299003062 conserved gate region; other site 743299003063 putative PBP binding loops; other site 743299003064 ABC-ATPase subunit interface; other site 743299003065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743299003066 dimer interface [polypeptide binding]; other site 743299003067 conserved gate region; other site 743299003068 putative PBP binding loops; other site 743299003069 ABC-ATPase subunit interface; other site 743299003070 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 743299003071 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 743299003072 Walker A/P-loop; other site 743299003073 ATP binding site [chemical binding]; other site 743299003074 Q-loop/lid; other site 743299003075 ABC transporter signature motif; other site 743299003076 Walker B; other site 743299003077 D-loop; other site 743299003078 H-loop/switch region; other site 743299003079 transcriptional regulator PhoU; Provisional; Region: PRK11115 743299003080 PhoU domain; Region: PhoU; pfam01895 743299003081 PhoU domain; Region: PhoU; pfam01895 743299003082 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 743299003083 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 743299003084 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743299003085 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 743299003086 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 743299003087 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 743299003088 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 743299003089 rRNA interaction site [nucleotide binding]; other site 743299003090 S8 interaction site; other site 743299003091 putative laminin-1 binding site; other site 743299003092 elongation factor Ts; Provisional; Region: tsf; PRK09377 743299003093 UBA/TS-N domain; Region: UBA; pfam00627 743299003094 Elongation factor TS; Region: EF_TS; pfam00889 743299003095 Elongation factor TS; Region: EF_TS; pfam00889 743299003096 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 743299003097 putative nucleotide binding site [chemical binding]; other site 743299003098 uridine monophosphate binding site [chemical binding]; other site 743299003099 homohexameric interface [polypeptide binding]; other site 743299003100 ribosome recycling factor; Reviewed; Region: frr; PRK00083 743299003101 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 743299003102 hinge region; other site 743299003103 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 743299003104 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 743299003105 catalytic residue [active] 743299003106 putative FPP diphosphate binding site; other site 743299003107 putative FPP binding hydrophobic cleft; other site 743299003108 dimer interface [polypeptide binding]; other site 743299003109 putative IPP diphosphate binding site; other site 743299003110 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 743299003111 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 743299003112 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 743299003113 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 743299003114 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 743299003115 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 743299003116 zinc metallopeptidase RseP; Provisional; Region: PRK10779 743299003117 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 743299003118 active site 743299003119 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 743299003120 protein binding site [polypeptide binding]; other site 743299003121 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 743299003122 protein binding site [polypeptide binding]; other site 743299003123 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 743299003124 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 743299003125 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743299003126 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743299003127 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743299003128 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743299003129 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743299003130 Surface antigen; Region: Bac_surface_Ag; pfam01103 743299003131 periplasmic chaperone; Provisional; Region: PRK10780 743299003132 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 743299003133 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 743299003134 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 743299003135 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 743299003136 trimer interface [polypeptide binding]; other site 743299003137 active site 743299003138 UDP-GlcNAc binding site [chemical binding]; other site 743299003139 lipid binding site [chemical binding]; lipid-binding site 743299003140 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 743299003141 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 743299003142 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 743299003143 active site 743299003144 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 743299003145 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 743299003146 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 743299003147 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 743299003148 inhibitor-cofactor binding pocket; inhibition site 743299003149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299003150 catalytic residue [active] 743299003151 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 743299003152 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 743299003153 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 743299003154 RNA/DNA hybrid binding site [nucleotide binding]; other site 743299003155 active site 743299003156 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 743299003157 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 743299003158 putative active site [active] 743299003159 putative PHP Thumb interface [polypeptide binding]; other site 743299003160 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 743299003161 generic binding surface I; other site 743299003162 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 743299003163 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 743299003164 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 743299003165 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 743299003166 Ligand Binding Site [chemical binding]; other site 743299003167 TilS substrate binding domain; Region: TilS; pfam09179 743299003168 TilS substrate C-terminal domain; Region: TilS_C; smart00977 743299003169 dihydroorotase; Provisional; Region: PRK07575 743299003170 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 743299003171 active site 743299003172 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 743299003173 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 743299003174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299003175 motif II; other site 743299003176 endo-1,4-D-glucanase; Provisional; Region: PRK11097 743299003177 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 743299003178 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 743299003179 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 743299003180 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 743299003181 DXD motif; other site 743299003182 PilZ domain; Region: PilZ; pfam07238 743299003183 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 743299003184 active site 743299003185 tetramer interface; other site 743299003186 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 743299003187 circadian clock protein KaiC; Reviewed; Region: PRK09302 743299003188 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299003189 Walker A motif; other site 743299003190 ATP binding site [chemical binding]; other site 743299003191 Walker B motif; other site 743299003192 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299003193 Walker A motif; other site 743299003194 Walker A motif; other site 743299003195 ATP binding site [chemical binding]; other site 743299003196 Walker B motif; other site 743299003197 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299003198 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299003199 metal binding site [ion binding]; metal-binding site 743299003200 active site 743299003201 I-site; other site 743299003202 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299003203 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 743299003204 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 743299003205 catalytic residue [active] 743299003206 putative FPP diphosphate binding site; other site 743299003207 putative FPP binding hydrophobic cleft; other site 743299003208 dimer interface [polypeptide binding]; other site 743299003209 putative IPP diphosphate binding site; other site 743299003210 circadian clock protein KaiC; Reviewed; Region: PRK09302 743299003211 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299003212 Walker A motif; other site 743299003213 ATP binding site [chemical binding]; other site 743299003214 Walker B motif; other site 743299003215 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299003216 Walker A motif; other site 743299003217 ATP binding site [chemical binding]; other site 743299003218 Walker B motif; other site 743299003219 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 743299003220 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 743299003221 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 743299003222 non-specific DNA interactions [nucleotide binding]; other site 743299003223 DNA binding site [nucleotide binding] 743299003224 sequence specific DNA binding site [nucleotide binding]; other site 743299003225 putative cAMP binding site [chemical binding]; other site 743299003226 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 743299003227 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 743299003228 Autotransporter beta-domain; Region: Autotransporter; pfam03797 743299003229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743299003230 dimerization interface [polypeptide binding]; other site 743299003231 putative DNA binding site [nucleotide binding]; other site 743299003232 putative Zn2+ binding site [ion binding]; other site 743299003233 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 743299003234 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 743299003235 Response regulator receiver domain; Region: Response_reg; pfam00072 743299003236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299003237 active site 743299003238 phosphorylation site [posttranslational modification] 743299003239 intermolecular recognition site; other site 743299003240 dimerization interface [polypeptide binding]; other site 743299003241 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299003242 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299003243 metal binding site [ion binding]; metal-binding site 743299003244 active site 743299003245 I-site; other site 743299003246 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299003247 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 743299003248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743299003249 putative active site [active] 743299003250 heme pocket [chemical binding]; other site 743299003251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743299003252 putative active site [active] 743299003253 heme pocket [chemical binding]; other site 743299003254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743299003255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299003256 dimer interface [polypeptide binding]; other site 743299003257 phosphorylation site [posttranslational modification] 743299003258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299003259 ATP binding site [chemical binding]; other site 743299003260 Mg2+ binding site [ion binding]; other site 743299003261 G-X-G motif; other site 743299003262 Response regulator receiver domain; Region: Response_reg; pfam00072 743299003263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299003264 active site 743299003265 phosphorylation site [posttranslational modification] 743299003266 intermolecular recognition site; other site 743299003267 dimerization interface [polypeptide binding]; other site 743299003268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299003269 S-adenosylmethionine binding site [chemical binding]; other site 743299003270 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 743299003271 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 743299003272 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743299003273 dimerization interface [polypeptide binding]; other site 743299003274 putative DNA binding site [nucleotide binding]; other site 743299003275 putative Zn2+ binding site [ion binding]; other site 743299003276 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743299003277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299003278 putative substrate translocation pore; other site 743299003279 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 743299003280 CsbD-like; Region: CsbD; pfam05532 743299003281 Transposase, Mutator family; Region: Transposase_mut; pfam00872 743299003282 excinuclease ABC subunit B; Provisional; Region: PRK05298 743299003283 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 743299003284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299003285 ATP-binding site [chemical binding]; other site 743299003286 ATP binding site [chemical binding]; other site 743299003287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743299003288 nucleotide binding region [chemical binding]; other site 743299003289 ATP-binding site [chemical binding]; other site 743299003290 Ultra-violet resistance protein B; Region: UvrB; pfam12344 743299003291 UvrB/uvrC motif; Region: UVR; pfam02151 743299003292 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 743299003293 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 743299003294 putative NAD(P) binding site [chemical binding]; other site 743299003295 putative substrate binding site [chemical binding]; other site 743299003296 catalytic Zn binding site [ion binding]; other site 743299003297 structural Zn binding site [ion binding]; other site 743299003298 dimer interface [polypeptide binding]; other site 743299003299 CTP synthetase; Validated; Region: pyrG; PRK05380 743299003300 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 743299003301 Catalytic site [active] 743299003302 active site 743299003303 UTP binding site [chemical binding]; other site 743299003304 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 743299003305 active site 743299003306 putative oxyanion hole; other site 743299003307 catalytic triad [active] 743299003308 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 743299003309 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 743299003310 enolase; Provisional; Region: eno; PRK00077 743299003311 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 743299003312 dimer interface [polypeptide binding]; other site 743299003313 metal binding site [ion binding]; metal-binding site 743299003314 substrate binding pocket [chemical binding]; other site 743299003315 Septum formation initiator; Region: DivIC; cl17659 743299003316 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 743299003317 elongation factor P; Validated; Region: PRK00529 743299003318 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 743299003319 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 743299003320 RNA binding site [nucleotide binding]; other site 743299003321 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 743299003322 RNA binding site [nucleotide binding]; other site 743299003323 Protein of unknown function (DUF971); Region: DUF971; pfam06155 743299003324 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 743299003325 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 743299003326 GIY-YIG motif/motif A; other site 743299003327 active site 743299003328 catalytic site [active] 743299003329 putative DNA binding site [nucleotide binding]; other site 743299003330 metal binding site [ion binding]; metal-binding site 743299003331 UvrB/uvrC motif; Region: UVR; pfam02151 743299003332 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 743299003333 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 743299003334 tRNA dihydrouridine synthase A; Region: yjbN; TIGR00742 743299003335 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 743299003336 FMN binding site [chemical binding]; other site 743299003337 active site 743299003338 catalytic residues [active] 743299003339 substrate binding site [chemical binding]; other site 743299003340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743299003341 dimerization interface [polypeptide binding]; other site 743299003342 putative DNA binding site [nucleotide binding]; other site 743299003343 putative Zn2+ binding site [ion binding]; other site 743299003344 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 743299003345 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 743299003346 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 743299003347 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 743299003348 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 743299003349 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 743299003350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299003351 ATP-grasp domain; Region: ATP-grasp; pfam02222 743299003352 aspartate aminotransferase; Provisional; Region: PRK05764 743299003353 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743299003354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299003355 homodimer interface [polypeptide binding]; other site 743299003356 catalytic residue [active] 743299003357 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 743299003358 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743299003359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299003360 Walker A/P-loop; other site 743299003361 ATP binding site [chemical binding]; other site 743299003362 Q-loop/lid; other site 743299003363 ABC transporter signature motif; other site 743299003364 Walker B; other site 743299003365 D-loop; other site 743299003366 H-loop/switch region; other site 743299003367 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 743299003368 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 743299003369 Uncharacterized conserved protein [Function unknown]; Region: COG0393 743299003370 Uncharacterized conserved protein [Function unknown]; Region: COG0393 743299003371 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 743299003372 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 743299003373 Domain of unknown function (DUF202); Region: DUF202; cl09954 743299003374 DsrE/DsrF-like family; Region: DrsE; pfam02635 743299003375 Domain of unknown function DUF302; Region: DUF302; cl01364 743299003376 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 743299003377 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 743299003378 TQO small subunit DoxD; Region: DoxD; pfam04173 743299003379 TQO small subunit DoxA; Region: DoxA; pfam07680 743299003380 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 743299003381 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 743299003382 putative RNA binding site [nucleotide binding]; other site 743299003383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299003384 S-adenosylmethionine binding site [chemical binding]; other site 743299003385 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 743299003386 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 743299003387 DNA gyrase subunit A; Validated; Region: PRK05560 743299003388 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 743299003389 CAP-like domain; other site 743299003390 active site 743299003391 primary dimer interface [polypeptide binding]; other site 743299003392 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743299003393 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743299003394 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743299003395 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743299003396 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743299003397 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743299003398 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 743299003399 homodimer interface [polypeptide binding]; other site 743299003400 substrate-cofactor binding pocket; other site 743299003401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299003402 catalytic residue [active] 743299003403 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 743299003404 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 743299003405 Prephenate dehydratase; Region: PDT; pfam00800 743299003406 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 743299003407 putative L-Phe binding site [chemical binding]; other site 743299003408 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 743299003409 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743299003410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299003411 homodimer interface [polypeptide binding]; other site 743299003412 catalytic residue [active] 743299003413 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 743299003414 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 743299003415 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 743299003416 prephenate dehydrogenase; Validated; Region: PRK08507 743299003417 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 743299003418 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 743299003419 hinge; other site 743299003420 active site 743299003421 cytidylate kinase; Provisional; Region: cmk; PRK00023 743299003422 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 743299003423 CMP-binding site; other site 743299003424 The sites determining sugar specificity; other site 743299003425 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 743299003426 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 743299003427 RNA binding site [nucleotide binding]; other site 743299003428 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 743299003429 RNA binding site [nucleotide binding]; other site 743299003430 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 743299003431 RNA binding site [nucleotide binding]; other site 743299003432 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 743299003433 RNA binding site [nucleotide binding]; other site 743299003434 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743299003435 RNA binding site [nucleotide binding]; other site 743299003436 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743299003437 RNA binding site [nucleotide binding]; other site 743299003438 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743299003439 IHF - DNA interface [nucleotide binding]; other site 743299003440 IHF dimer interface [polypeptide binding]; other site 743299003441 tetratricopeptide repeat protein; Provisional; Region: PRK11788 743299003442 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299003443 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 743299003444 active site 743299003445 dimer interface [polypeptide binding]; other site 743299003446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743299003447 active site 743299003448 trigger factor; Provisional; Region: tig; PRK01490 743299003449 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743299003450 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 743299003451 Clp protease; Region: CLP_protease; pfam00574 743299003452 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 743299003453 oligomer interface [polypeptide binding]; other site 743299003454 active site residues [active] 743299003455 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 743299003456 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 743299003457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299003458 Walker A motif; other site 743299003459 ATP binding site [chemical binding]; other site 743299003460 Walker B motif; other site 743299003461 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 743299003462 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 743299003463 Found in ATP-dependent protease La (LON); Region: LON; smart00464 743299003464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299003465 Walker A motif; other site 743299003466 ATP binding site [chemical binding]; other site 743299003467 Walker B motif; other site 743299003468 arginine finger; other site 743299003469 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 743299003470 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743299003471 IHF dimer interface [polypeptide binding]; other site 743299003472 IHF - DNA interface [nucleotide binding]; other site 743299003473 SurA N-terminal domain; Region: SurA_N_3; pfam13624 743299003474 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 743299003475 LexA repressor; Validated; Region: PRK00215 743299003476 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 743299003477 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 743299003478 Catalytic site [active] 743299003479 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299003480 aminopeptidase N; Provisional; Region: pepN; PRK14015 743299003481 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 743299003482 active site 743299003483 Zn binding site [ion binding]; other site 743299003484 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 743299003485 putative active site [active] 743299003486 putative metal binding residues [ion binding]; other site 743299003487 signature motif; other site 743299003488 putative triphosphate binding site [ion binding]; other site 743299003489 CHAD domain; Region: CHAD; pfam05235 743299003490 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743299003491 ParA-like protein; Provisional; Region: PHA02518 743299003492 P-loop; other site 743299003493 Magnesium ion binding site [ion binding]; other site 743299003494 polyphosphate kinase; Provisional; Region: PRK05443 743299003495 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 743299003496 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 743299003497 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 743299003498 putative domain interface [polypeptide binding]; other site 743299003499 putative active site [active] 743299003500 catalytic site [active] 743299003501 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 743299003502 putative domain interface [polypeptide binding]; other site 743299003503 putative active site [active] 743299003504 catalytic site [active] 743299003505 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 743299003506 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 743299003507 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 743299003508 homodimer interface [polypeptide binding]; other site 743299003509 NADP binding site [chemical binding]; other site 743299003510 substrate binding site [chemical binding]; other site 743299003511 multidrug efflux protein; Reviewed; Region: PRK09579 743299003512 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743299003513 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743299003514 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299003515 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 743299003516 Tetratricopeptide repeat; Region: TPR_16; pfam13432 743299003517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299003518 TPR motif; other site 743299003519 Maf-like protein; Region: Maf; pfam02545 743299003520 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 743299003521 active site 743299003522 dimer interface [polypeptide binding]; other site 743299003523 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 743299003524 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 743299003525 bacterial Hfq-like; Region: Hfq; cd01716 743299003526 hexamer interface [polypeptide binding]; other site 743299003527 Sm1 motif; other site 743299003528 RNA binding site [nucleotide binding]; other site 743299003529 Sm2 motif; other site 743299003530 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 743299003531 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 743299003532 HflX GTPase family; Region: HflX; cd01878 743299003533 G1 box; other site 743299003534 GTP/Mg2+ binding site [chemical binding]; other site 743299003535 Switch I region; other site 743299003536 G2 box; other site 743299003537 G3 box; other site 743299003538 Switch II region; other site 743299003539 G4 box; other site 743299003540 G5 box; other site 743299003541 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 743299003542 HflK protein; Region: hflK; TIGR01933 743299003543 HflC protein; Region: hflC; TIGR01932 743299003544 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 743299003545 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 743299003546 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 743299003547 dimer interface [polypeptide binding]; other site 743299003548 motif 1; other site 743299003549 active site 743299003550 motif 2; other site 743299003551 motif 3; other site 743299003552 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 743299003553 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 743299003554 GDP-binding site [chemical binding]; other site 743299003555 ACT binding site; other site 743299003556 IMP binding site; other site 743299003557 ribonuclease R; Region: RNase_R; TIGR02063 743299003558 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 743299003559 RNB domain; Region: RNB; pfam00773 743299003560 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 743299003561 RNA binding site [nucleotide binding]; other site 743299003562 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 743299003563 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 743299003564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743299003565 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743299003566 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 743299003567 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 743299003568 putative MPT binding site; other site 743299003569 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 743299003570 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 743299003571 active site 743299003572 substrate binding site [chemical binding]; other site 743299003573 cosubstrate binding site; other site 743299003574 catalytic site [active] 743299003575 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 743299003576 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 743299003577 dimerization interface [polypeptide binding]; other site 743299003578 putative ATP binding site [chemical binding]; other site 743299003579 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 743299003580 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 743299003581 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 743299003582 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 743299003583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299003584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 743299003585 Walker A motif; other site 743299003586 ATP binding site [chemical binding]; other site 743299003587 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 743299003588 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 743299003589 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 743299003590 putative phosphate acyltransferase; Provisional; Region: PRK05331 743299003591 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 743299003592 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 743299003593 dimer interface [polypeptide binding]; other site 743299003594 active site 743299003595 CoA binding pocket [chemical binding]; other site 743299003596 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 743299003597 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 743299003598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299003599 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 743299003600 NAD(P) binding site [chemical binding]; other site 743299003601 active site 743299003602 acyl carrier protein; Provisional; Region: acpP; PRK00982 743299003603 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 743299003604 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 743299003605 dimer interface [polypeptide binding]; other site 743299003606 active site 743299003607 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 743299003608 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 743299003609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299003610 catalytic residue [active] 743299003611 YceG-like family; Region: YceG; pfam02618 743299003612 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 743299003613 dimerization interface [polypeptide binding]; other site 743299003614 thymidylate kinase; Validated; Region: tmk; PRK00698 743299003615 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 743299003616 TMP-binding site; other site 743299003617 ATP-binding site [chemical binding]; other site 743299003618 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 743299003619 PilZ domain; Region: PilZ; cl01260 743299003620 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 743299003621 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 743299003622 YcfA-like protein; Region: YcfA; pfam07927 743299003623 Domain of unknown function DUF302; Region: DUF302; cl01364 743299003624 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 743299003625 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 743299003626 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 743299003627 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 743299003628 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 743299003629 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 743299003630 [4Fe-4S] binding site [ion binding]; other site 743299003631 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 743299003632 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 743299003633 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 743299003634 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 743299003635 molybdopterin cofactor binding site; other site 743299003636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299003637 putative substrate translocation pore; other site 743299003638 Hemerythrin-like domain; Region: Hr-like; cd12108 743299003639 Fe binding site [ion binding]; other site 743299003640 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 743299003641 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 743299003642 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743299003643 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 743299003644 putative C-terminal domain interface [polypeptide binding]; other site 743299003645 putative GSH binding site (G-site) [chemical binding]; other site 743299003646 putative dimer interface [polypeptide binding]; other site 743299003647 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 743299003648 N-terminal domain interface [polypeptide binding]; other site 743299003649 dimer interface [polypeptide binding]; other site 743299003650 substrate binding pocket (H-site) [chemical binding]; other site 743299003651 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 743299003652 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 743299003653 gating phenylalanine in ion channel; other site 743299003654 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 743299003655 PLD-like domain; Region: PLDc_2; pfam13091 743299003656 putative active site [active] 743299003657 catalytic site [active] 743299003658 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 743299003659 PLD-like domain; Region: PLDc_2; pfam13091 743299003660 putative active site [active] 743299003661 putative catalytic site [active] 743299003662 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 743299003663 outer membrane porin, OprD family; Region: OprD; pfam03573 743299003664 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 743299003665 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 743299003666 Autoinducer binding domain; Region: Autoind_bind; pfam03472 743299003667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743299003668 DNA binding residues [nucleotide binding] 743299003669 dimerization interface [polypeptide binding]; other site 743299003670 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 743299003671 SnoaL-like domain; Region: SnoaL_2; pfam12680 743299003672 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 743299003673 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 743299003674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299003675 catalytic residue [active] 743299003676 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 743299003677 EamA-like transporter family; Region: EamA; pfam00892 743299003678 EamA-like transporter family; Region: EamA; pfam00892 743299003679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743299003680 dimerization interface [polypeptide binding]; other site 743299003681 putative DNA binding site [nucleotide binding]; other site 743299003682 HTH domain; Region: HTH_11; pfam08279 743299003683 Predicted transcriptional regulator [Transcription]; Region: COG2378 743299003684 WYL domain; Region: WYL; pfam13280 743299003685 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743299003686 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 743299003687 putative dimer interface [polypeptide binding]; other site 743299003688 hypothetical protein; Provisional; Region: PRK02268 743299003689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743299003690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743299003691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 743299003692 SnoaL-like domain; Region: SnoaL_2; pfam12680 743299003693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299003694 putative substrate translocation pore; other site 743299003695 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743299003696 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 743299003697 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743299003698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299003699 homodimer interface [polypeptide binding]; other site 743299003700 catalytic residue [active] 743299003701 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743299003702 Predicted flavoprotein [General function prediction only]; Region: COG0431 743299003703 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 743299003704 putative hydrophobic ligand binding site [chemical binding]; other site 743299003705 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 743299003706 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 743299003707 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 743299003708 conserved cys residue [active] 743299003709 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743299003710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743299003711 Coenzyme A binding pocket [chemical binding]; other site 743299003712 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 743299003713 Uncharacterized conserved protein [Function unknown]; Region: COG3791 743299003714 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 743299003715 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 743299003716 HipA N-terminal domain; Region: Couple_hipA; pfam13657 743299003717 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 743299003718 HipA-like N-terminal domain; Region: HipA_N; pfam07805 743299003719 HipA-like C-terminal domain; Region: HipA_C; pfam07804 743299003720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743299003721 non-specific DNA binding site [nucleotide binding]; other site 743299003722 salt bridge; other site 743299003723 sequence-specific DNA binding site [nucleotide binding]; other site 743299003724 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 743299003725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299003726 Walker A motif; other site 743299003727 ATP binding site [chemical binding]; other site 743299003728 DNA polymerase III subunit delta'; Validated; Region: PRK08485 743299003729 Walker B motif; other site 743299003730 arginine finger; other site 743299003731 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 743299003732 hypothetical protein; Validated; Region: PRK00153 743299003733 recombination protein RecR; Reviewed; Region: recR; PRK00076 743299003734 RecR protein; Region: RecR; pfam02132 743299003735 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 743299003736 putative active site [active] 743299003737 putative metal-binding site [ion binding]; other site 743299003738 tetramer interface [polypeptide binding]; other site 743299003739 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 743299003740 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 743299003741 putative substrate binding site [chemical binding]; other site 743299003742 putative ATP binding site [chemical binding]; other site 743299003743 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743299003744 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 743299003745 inhibitor-cofactor binding pocket; inhibition site 743299003746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299003747 catalytic residue [active] 743299003748 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 743299003749 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 743299003750 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 743299003751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299003752 ATP binding site [chemical binding]; other site 743299003753 Mg2+ binding site [ion binding]; other site 743299003754 G-X-G motif; other site 743299003755 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 743299003756 ATP binding site [chemical binding]; other site 743299003757 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 743299003758 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 743299003759 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 743299003760 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 743299003761 active site 743299003762 multimer interface [polypeptide binding]; other site 743299003763 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 743299003764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299003765 FeS/SAM binding site; other site 743299003766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299003767 binding surface 743299003768 TPR motif; other site 743299003769 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 743299003770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743299003771 non-specific DNA binding site [nucleotide binding]; other site 743299003772 salt bridge; other site 743299003773 sequence-specific DNA binding site [nucleotide binding]; other site 743299003774 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 743299003775 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 743299003776 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 743299003777 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 743299003778 histidyl-tRNA synthetase; Region: hisS; TIGR00442 743299003779 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 743299003780 dimer interface [polypeptide binding]; other site 743299003781 motif 1; other site 743299003782 active site 743299003783 motif 2; other site 743299003784 motif 3; other site 743299003785 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 743299003786 anticodon binding site; other site 743299003787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 743299003788 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 743299003789 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 743299003790 Trp docking motif [polypeptide binding]; other site 743299003791 active site 743299003792 GTP-binding protein Der; Reviewed; Region: PRK00093 743299003793 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 743299003794 G1 box; other site 743299003795 GTP/Mg2+ binding site [chemical binding]; other site 743299003796 Switch I region; other site 743299003797 G2 box; other site 743299003798 Switch II region; other site 743299003799 G3 box; other site 743299003800 G4 box; other site 743299003801 G5 box; other site 743299003802 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 743299003803 G1 box; other site 743299003804 GTP/Mg2+ binding site [chemical binding]; other site 743299003805 Switch I region; other site 743299003806 G2 box; other site 743299003807 G3 box; other site 743299003808 Switch II region; other site 743299003809 G4 box; other site 743299003810 G5 box; other site 743299003811 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 743299003812 catalytic core [active] 743299003813 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 743299003814 PBP superfamily domain; Region: PBP_like_2; cl17296 743299003815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743299003816 dimer interface [polypeptide binding]; other site 743299003817 conserved gate region; other site 743299003818 putative PBP binding loops; other site 743299003819 ABC-ATPase subunit interface; other site 743299003820 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 743299003821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743299003822 dimer interface [polypeptide binding]; other site 743299003823 conserved gate region; other site 743299003824 putative PBP binding loops; other site 743299003825 ABC-ATPase subunit interface; other site 743299003826 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 743299003827 Hemerythrin-like domain; Region: Hr-like; cd12108 743299003828 Fe binding site [ion binding]; other site 743299003829 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 743299003830 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 743299003831 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 743299003832 amphipathic channel; other site 743299003833 Asn-Pro-Ala signature motifs; other site 743299003834 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 743299003835 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 743299003836 P loop; other site 743299003837 Nucleotide binding site [chemical binding]; other site 743299003838 DTAP/Switch II; other site 743299003839 Switch I; other site 743299003840 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 743299003841 DTAP/Switch II; other site 743299003842 Switch I; other site 743299003843 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 743299003844 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 743299003845 Low molecular weight phosphatase family; Region: LMWPc; cd00115 743299003846 active site 743299003847 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743299003848 dimerization interface [polypeptide binding]; other site 743299003849 putative DNA binding site [nucleotide binding]; other site 743299003850 putative Zn2+ binding site [ion binding]; other site 743299003851 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 743299003852 heme-binding site [chemical binding]; other site 743299003853 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 743299003854 putative active site [active] 743299003855 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 743299003856 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 743299003857 Fic/DOC family; Region: Fic; cl00960 743299003858 PemK-like protein; Region: PemK; cl00995 743299003859 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 743299003860 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 743299003861 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 743299003862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 743299003863 Predicted transcriptional regulator [Transcription]; Region: COG3905 743299003864 Uncharacterized conserved small protein [Function unknown]; Region: COG5428 743299003865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 743299003866 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 743299003867 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 743299003868 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743299003869 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743299003870 Helix-turn-helix domain; Region: HTH_17; cl17695 743299003871 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 743299003872 Sel1-like repeats; Region: SEL1; smart00671 743299003873 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 743299003874 [2Fe-2S] cluster binding site [ion binding]; other site 743299003875 AAA domain; Region: AAA_17; pfam13207 743299003876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 743299003877 Transposase; Region: DDE_Tnp_ISL3; pfam01610 743299003878 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1569 743299003879 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 743299003880 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 743299003881 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 743299003882 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 743299003883 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 743299003884 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 743299003885 putative active site [active] 743299003886 heat shock protein 90; Provisional; Region: PRK05218 743299003887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299003888 ATP binding site [chemical binding]; other site 743299003889 Mg2+ binding site [ion binding]; other site 743299003890 G-X-G motif; other site 743299003891 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 743299003892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743299003893 sequence-specific DNA binding site [nucleotide binding]; other site 743299003894 salt bridge; other site 743299003895 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 743299003896 Fic family protein [Function unknown]; Region: COG3177 743299003897 Fic/DOC family; Region: Fic; pfam02661 743299003898 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 743299003899 Fic family protein [Function unknown]; Region: COG3177 743299003900 Fic/DOC family; Region: Fic; pfam02661 743299003901 PAS domain S-box; Region: sensory_box; TIGR00229 743299003902 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743299003903 GAF domain; Region: GAF; pfam01590 743299003904 PAS domain; Region: PAS_9; pfam13426 743299003905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743299003906 putative active site [active] 743299003907 heme pocket [chemical binding]; other site 743299003908 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299003909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299003910 metal binding site [ion binding]; metal-binding site 743299003911 active site 743299003912 I-site; other site 743299003913 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299003914 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 743299003915 PilZ domain; Region: PilZ; pfam07238 743299003916 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 743299003917 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 743299003918 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 743299003919 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 743299003920 DXD motif; other site 743299003921 Cellulose synthase-like protein; Region: PLN02893 743299003922 PilZ domain; Region: PilZ; pfam07238 743299003923 cellulose synthase regulator protein; Provisional; Region: PRK11114 743299003924 endo-1,4-D-glucanase; Provisional; Region: PRK11097 743299003925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299003926 binding surface 743299003927 TPR motif; other site 743299003928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299003929 TPR motif; other site 743299003930 binding surface 743299003931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743299003932 binding surface 743299003933 TPR motif; other site 743299003934 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 743299003935 enoyl-CoA hydratase; Validated; Region: PRK08788 743299003936 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743299003937 substrate binding site [chemical binding]; other site 743299003938 oxyanion hole (OAH) forming residues; other site 743299003939 trimer interface [polypeptide binding]; other site 743299003940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299003941 dimer interface [polypeptide binding]; other site 743299003942 phosphorylation site [posttranslational modification] 743299003943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299003944 ATP binding site [chemical binding]; other site 743299003945 Mg2+ binding site [ion binding]; other site 743299003946 G-X-G motif; other site 743299003947 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743299003948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299003949 active site 743299003950 phosphorylation site [posttranslational modification] 743299003951 intermolecular recognition site; other site 743299003952 dimerization interface [polypeptide binding]; other site 743299003953 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 743299003954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299003955 active site 743299003956 phosphorylation site [posttranslational modification] 743299003957 intermolecular recognition site; other site 743299003958 dimerization interface [polypeptide binding]; other site 743299003959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743299003960 Zn2+ binding site [ion binding]; other site 743299003961 Mg2+ binding site [ion binding]; other site 743299003962 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 743299003963 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 743299003964 DXD motif; other site 743299003965 PilZ domain; Region: PilZ; pfam07238 743299003966 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 743299003967 endo-1,4-D-glucanase; Provisional; Region: PRK11097 743299003968 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299003969 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299003970 metal binding site [ion binding]; metal-binding site 743299003971 active site 743299003972 I-site; other site 743299003973 Protein of unknown function, DUF481; Region: DUF481; pfam04338 743299003974 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 743299003975 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 743299003976 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 743299003977 Walker A/P-loop; other site 743299003978 ATP binding site [chemical binding]; other site 743299003979 Q-loop/lid; other site 743299003980 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 743299003981 ABC transporter signature motif; other site 743299003982 Walker B; other site 743299003983 D-loop; other site 743299003984 H-loop/switch region; other site 743299003985 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 743299003986 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 743299003987 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 743299003988 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 743299003989 nucleotide binding pocket [chemical binding]; other site 743299003990 K-X-D-G motif; other site 743299003991 catalytic site [active] 743299003992 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 743299003993 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 743299003994 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 743299003995 Dimer interface [polypeptide binding]; other site 743299003996 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 743299003997 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 743299003998 gamma subunit interface [polypeptide binding]; other site 743299003999 epsilon subunit interface [polypeptide binding]; other site 743299004000 LBP interface [polypeptide binding]; other site 743299004001 Domain of unknown function (DUF202); Region: DUF202; pfam02656 743299004002 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 743299004003 metal binding site 2 [ion binding]; metal-binding site 743299004004 putative DNA binding helix; other site 743299004005 metal binding site 1 [ion binding]; metal-binding site 743299004006 dimer interface [polypeptide binding]; other site 743299004007 structural Zn2+ binding site [ion binding]; other site 743299004008 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 743299004009 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743299004010 catalytic triad [active] 743299004011 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 743299004012 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 743299004013 putative active site [active] 743299004014 PhoH-like protein; Region: PhoH; pfam02562 743299004015 arginine decarboxylase; Provisional; Region: PRK05354 743299004016 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 743299004017 dimer interface [polypeptide binding]; other site 743299004018 active site 743299004019 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743299004020 catalytic residues [active] 743299004021 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 743299004022 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 743299004023 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 743299004024 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 743299004025 dimer interface [polypeptide binding]; other site 743299004026 [2Fe-2S] cluster binding site [ion binding]; other site 743299004027 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 743299004028 oxidoreductase; Provisional; Region: PRK10015 743299004029 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 743299004030 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 743299004031 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 743299004032 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 743299004033 Ligand binding site [chemical binding]; other site 743299004034 Electron transfer flavoprotein domain; Region: ETF; pfam01012 743299004035 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743299004036 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 743299004037 molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168 743299004038 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 743299004039 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 743299004040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299004041 Walker A motif; other site 743299004042 ATP binding site [chemical binding]; other site 743299004043 Walker B motif; other site 743299004044 arginine finger; other site 743299004045 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 743299004046 iron-sulfur cluster [ion binding]; other site 743299004047 [2Fe-2S] cluster binding site [ion binding]; other site 743299004048 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 743299004049 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 743299004050 active site residue [active] 743299004051 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 743299004052 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 743299004053 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 743299004054 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 743299004055 NADPH bind site [chemical binding]; other site 743299004056 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 743299004057 putative FMN binding site [chemical binding]; other site 743299004058 NADPH bind site [chemical binding]; other site 743299004059 Nitrogen fixation protein NifW; Region: NifW; pfam03206 743299004060 serine O-acetyltransferase; Region: cysE; TIGR01172 743299004061 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 743299004062 trimer interface [polypeptide binding]; other site 743299004063 active site 743299004064 substrate binding site [chemical binding]; other site 743299004065 CoA binding site [chemical binding]; other site 743299004066 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 743299004067 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 743299004068 active site 743299004069 catalytic residues [active] 743299004070 metal binding site [ion binding]; metal-binding site 743299004071 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 743299004072 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 743299004073 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743299004074 catalytic residue [active] 743299004075 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 743299004076 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 743299004077 trimerization site [polypeptide binding]; other site 743299004078 active site 743299004079 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 743299004080 NifU-like domain; Region: NifU; pfam01106 743299004081 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 743299004082 NifQ; Region: NifQ; pfam04891 743299004083 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 743299004084 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 743299004085 Rop-like; Region: Rop-like; pfam05082 743299004086 probable nitrogen fixation protein; Region: TIGR02935 743299004087 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 743299004088 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 743299004089 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 743299004090 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 743299004091 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 743299004092 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 743299004093 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743299004094 catalytic loop [active] 743299004095 iron binding site [ion binding]; other site 743299004096 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 743299004097 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743299004098 catalytic loop [active] 743299004099 iron binding site [ion binding]; other site 743299004100 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 743299004101 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 743299004102 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 743299004103 MoFe protein beta/alpha subunit interactions; other site 743299004104 Beta subunit P cluster binding residues; other site 743299004105 MoFe protein beta subunit/Fe protein contacts; other site 743299004106 MoFe protein dimer/ dimer interactions; other site 743299004107 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 743299004108 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 743299004109 MoFe protein alpha/beta subunit interactions; other site 743299004110 Alpha subunit P cluster binding residues; other site 743299004111 FeMoco binding residues [chemical binding]; other site 743299004112 MoFe protein alpha subunit/Fe protein contacts; other site 743299004113 MoFe protein dimer/ dimer interactions; other site 743299004114 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 743299004115 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 743299004116 Nucleotide-binding sites [chemical binding]; other site 743299004117 Walker A motif; other site 743299004118 Switch I region of nucleotide binding site; other site 743299004119 Fe4S4 binding sites [ion binding]; other site 743299004120 Switch II region of nucleotide binding site; other site 743299004121 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 743299004122 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 743299004123 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 743299004124 ArsC family; Region: ArsC; pfam03960 743299004125 putative catalytic residues [active] 743299004126 Nif-specific regulatory protein; Region: nifA; TIGR01817 743299004127 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 743299004128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299004129 Walker A motif; other site 743299004130 ATP binding site [chemical binding]; other site 743299004131 Walker B motif; other site 743299004132 arginine finger; other site 743299004133 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743299004134 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 743299004135 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299004136 FeS/SAM binding site; other site 743299004137 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 743299004138 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 743299004139 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 743299004140 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 743299004141 HEAT repeats; Region: HEAT_2; pfam13646 743299004142 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 743299004143 protein binding surface [polypeptide binding]; other site 743299004144 NifZ domain; Region: NifZ; pfam04319 743299004145 NifZ domain; Region: NifZ; pfam04319 743299004146 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 743299004147 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 743299004148 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743299004149 catalytic residue [active] 743299004150 NifT/FixU protein; Region: NifT; pfam06988 743299004151 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 743299004152 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 743299004153 inhibitor-cofactor binding pocket; inhibition site 743299004154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299004155 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 743299004156 catalytic loop [active] 743299004157 iron binding site [ion binding]; other site 743299004158 SIR2-like domain; Region: SIR2_2; pfam13289 743299004159 Predicted transcriptional regulator [Transcription]; Region: COG1959 743299004160 Transcriptional regulator; Region: Rrf2; pfam02082 743299004161 Transcriptional regulator; Region: Rrf2; cl17282 743299004162 molybdenum transport protein ModD; Provisional; Region: PRK06096 743299004163 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 743299004164 dimerization interface [polypeptide binding]; other site 743299004165 active site 743299004166 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743299004167 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743299004168 tetramerization interface [polypeptide binding]; other site 743299004169 NAD(P) binding site [chemical binding]; other site 743299004170 catalytic residues [active] 743299004171 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 743299004172 apolar tunnel; other site 743299004173 heme binding site [chemical binding]; other site 743299004174 dimerization interface [polypeptide binding]; other site 743299004175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299004176 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743299004177 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743299004178 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743299004179 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 743299004180 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 743299004181 putative substrate binding site [chemical binding]; other site 743299004182 putative ATP binding site [chemical binding]; other site 743299004183 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 743299004184 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 743299004185 putative ADP-binding pocket [chemical binding]; other site 743299004186 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 743299004187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 743299004188 active site 743299004189 motif I; other site 743299004190 motif II; other site 743299004191 sucrose synthase; Region: sucr_synth; TIGR02470 743299004192 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 743299004193 putative ADP-binding pocket [chemical binding]; other site 743299004194 RES domain; Region: RES; pfam08808 743299004195 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 743299004196 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 743299004197 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 743299004198 AlkA N-terminal domain; Region: AlkA_N; pfam06029 743299004199 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 743299004200 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743299004201 minor groove reading motif; other site 743299004202 helix-hairpin-helix signature motif; other site 743299004203 substrate binding pocket [chemical binding]; other site 743299004204 active site 743299004205 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 743299004206 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 743299004207 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 743299004208 DNA binding site [nucleotide binding] 743299004209 active site 743299004210 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 743299004211 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743299004212 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743299004213 putative DNA binding site [nucleotide binding]; other site 743299004214 putative Zn2+ binding site [ion binding]; other site 743299004215 AsnC family; Region: AsnC_trans_reg; pfam01037 743299004216 2-isopropylmalate synthase; Validated; Region: PRK03739 743299004217 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 743299004218 active site 743299004219 catalytic residues [active] 743299004220 metal binding site [ion binding]; metal-binding site 743299004221 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 743299004222 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 743299004223 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743299004224 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 743299004225 Soluble P-type ATPase [General function prediction only]; Region: COG4087 743299004226 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 743299004227 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743299004228 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 743299004229 putative active site [active] 743299004230 putative metal binding site [ion binding]; other site 743299004231 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 743299004232 substrate binding site [chemical binding]; other site 743299004233 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 743299004234 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 743299004235 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 743299004236 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 743299004237 generic binding surface II; other site 743299004238 generic binding surface I; other site 743299004239 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743299004240 catalytic residues [active] 743299004241 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 743299004242 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743299004243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299004244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743299004245 putative substrate translocation pore; other site 743299004246 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 743299004247 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 743299004248 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 743299004249 substrate binding pocket [chemical binding]; other site 743299004250 chain length determination region; other site 743299004251 substrate-Mg2+ binding site; other site 743299004252 catalytic residues [active] 743299004253 aspartate-rich region 1; other site 743299004254 active site lid residues [active] 743299004255 aspartate-rich region 2; other site 743299004256 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 743299004257 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 743299004258 TPP-binding site; other site 743299004259 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 743299004260 PYR/PP interface [polypeptide binding]; other site 743299004261 dimer interface [polypeptide binding]; other site 743299004262 TPP binding site [chemical binding]; other site 743299004263 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743299004264 putative GTP cyclohydrolase; Provisional; Region: PRK13674 743299004265 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 743299004266 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 743299004267 Tetramer interface [polypeptide binding]; other site 743299004268 active site 743299004269 FMN-binding site [chemical binding]; other site 743299004270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299004271 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743299004272 putative substrate translocation pore; other site 743299004273 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 743299004274 Clp amino terminal domain; Region: Clp_N; pfam02861 743299004275 Clp amino terminal domain; Region: Clp_N; pfam02861 743299004276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299004277 Walker A motif; other site 743299004278 ATP binding site [chemical binding]; other site 743299004279 Walker B motif; other site 743299004280 arginine finger; other site 743299004281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299004282 Walker A motif; other site 743299004283 ATP binding site [chemical binding]; other site 743299004284 Walker B motif; other site 743299004285 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 743299004286 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743299004287 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 743299004288 putative ADP-binding pocket [chemical binding]; other site 743299004289 acetyl-CoA synthetase; Provisional; Region: PRK00174 743299004290 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 743299004291 active site 743299004292 CoA binding site [chemical binding]; other site 743299004293 acyl-activating enzyme (AAE) consensus motif; other site 743299004294 AMP binding site [chemical binding]; other site 743299004295 acetate binding site [chemical binding]; other site 743299004296 putative cation:proton antiport protein; Provisional; Region: PRK10669 743299004297 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 743299004298 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 743299004299 TrkA-N domain; Region: TrkA_N; pfam02254 743299004300 TrkA-C domain; Region: TrkA_C; pfam02080 743299004301 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 743299004302 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 743299004303 NADP binding site [chemical binding]; other site 743299004304 homopentamer interface [polypeptide binding]; other site 743299004305 substrate binding site [chemical binding]; other site 743299004306 active site 743299004307 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743299004308 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 743299004309 putative NAD(P) binding site [chemical binding]; other site 743299004310 active site 743299004311 putative substrate binding site [chemical binding]; other site 743299004312 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 743299004313 Fatty acid desaturase; Region: FA_desaturase; pfam00487 743299004314 putative di-iron ligands [ion binding]; other site 743299004315 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 743299004316 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299004317 rusticyanin; Region: rusti_cyanin; TIGR03095 743299004318 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 743299004319 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 743299004320 active site 743299004321 DNA polymerase IV; Validated; Region: PRK02406 743299004322 DNA binding site [nucleotide binding] 743299004323 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 743299004324 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 743299004325 oligomeric interface; other site 743299004326 putative active site [active] 743299004327 homodimer interface [polypeptide binding]; other site 743299004328 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 743299004329 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 743299004330 dimer interface [polypeptide binding]; other site 743299004331 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743299004332 metal binding site [ion binding]; metal-binding site 743299004333 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 743299004334 TspO/MBR family; Region: TspO_MBR; pfam03073 743299004335 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 743299004336 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 743299004337 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 743299004338 active site 743299004339 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 743299004340 H-NS histone family; Region: Histone_HNS; pfam00816 743299004341 HNH endonuclease; Region: HNH_5; pfam14279 743299004342 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 743299004343 metal binding site 2 [ion binding]; metal-binding site 743299004344 putative DNA binding helix; other site 743299004345 metal binding site 1 [ion binding]; metal-binding site 743299004346 structural Zn2+ binding site [ion binding]; other site 743299004347 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 743299004348 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 743299004349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 743299004350 Family of unknown function (DUF490); Region: DUF490; pfam04357 743299004351 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 743299004352 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743299004353 Surface antigen; Region: Bac_surface_Ag; pfam01103 743299004354 muropeptide transporter; Validated; Region: ampG; cl17669 743299004355 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 743299004356 catalytic triad [active] 743299004357 conserved cis-peptide bond; other site 743299004358 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 743299004359 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 743299004360 active site 743299004361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299004362 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743299004363 putative substrate translocation pore; other site 743299004364 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 743299004365 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 743299004366 dimerization interface [polypeptide binding]; other site 743299004367 domain crossover interface; other site 743299004368 redox-dependent activation switch; other site 743299004369 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 743299004370 Ligand Binding Site [chemical binding]; other site 743299004371 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 743299004372 putative ribose interaction site [chemical binding]; other site 743299004373 putative ADP binding site [chemical binding]; other site 743299004374 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 743299004375 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 743299004376 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 743299004377 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 743299004378 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 743299004379 active site 743299004380 hydrophilic channel; other site 743299004381 dimerization interface [polypeptide binding]; other site 743299004382 catalytic residues [active] 743299004383 active site lid [active] 743299004384 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 743299004385 Recombination protein O N terminal; Region: RecO_N; pfam11967 743299004386 Recombination protein O C terminal; Region: RecO_C; pfam02565 743299004387 GTPase Era; Reviewed; Region: era; PRK00089 743299004388 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 743299004389 G1 box; other site 743299004390 GTP/Mg2+ binding site [chemical binding]; other site 743299004391 Switch I region; other site 743299004392 G2 box; other site 743299004393 Switch II region; other site 743299004394 G3 box; other site 743299004395 G4 box; other site 743299004396 G5 box; other site 743299004397 KH domain; Region: KH_2; pfam07650 743299004398 ribonuclease III; Reviewed; Region: rnc; PRK00102 743299004399 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 743299004400 dimerization interface [polypeptide binding]; other site 743299004401 active site 743299004402 metal binding site [ion binding]; metal-binding site 743299004403 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 743299004404 dsRNA binding site [nucleotide binding]; other site 743299004405 signal peptidase I; Provisional; Region: PRK10861 743299004406 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 743299004407 Catalytic site [active] 743299004408 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 743299004409 GTP-binding protein LepA; Provisional; Region: PRK05433 743299004410 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 743299004411 G1 box; other site 743299004412 putative GEF interaction site [polypeptide binding]; other site 743299004413 GTP/Mg2+ binding site [chemical binding]; other site 743299004414 Switch I region; other site 743299004415 G2 box; other site 743299004416 G3 box; other site 743299004417 Switch II region; other site 743299004418 G4 box; other site 743299004419 G5 box; other site 743299004420 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 743299004421 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 743299004422 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 743299004423 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 743299004424 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 743299004425 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743299004426 protein binding site [polypeptide binding]; other site 743299004427 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743299004428 protein binding site [polypeptide binding]; other site 743299004429 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 743299004430 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 743299004431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743299004432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743299004433 DNA binding residues [nucleotide binding] 743299004434 L-aspartate oxidase; Provisional; Region: PRK06175 743299004435 L-aspartate oxidase; Provisional; Region: PRK09077 743299004436 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 743299004437 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 743299004438 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 743299004439 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 743299004440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 743299004441 FIST N domain; Region: FIST; pfam08495 743299004442 FIST C domain; Region: FIST_C; pfam10442 743299004443 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 743299004444 putative hydrolase; Provisional; Region: PRK02113 743299004445 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 743299004446 active site 743299004447 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 743299004448 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 743299004449 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 743299004450 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 743299004451 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 743299004452 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 743299004453 active site 743299004454 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 743299004455 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 743299004456 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 743299004457 dimer interface [polypeptide binding]; other site 743299004458 decamer (pentamer of dimers) interface [polypeptide binding]; other site 743299004459 catalytic triad [active] 743299004460 peroxidatic and resolving cysteines [active] 743299004461 Ferredoxin [Energy production and conversion]; Region: COG1146 743299004462 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 743299004463 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 743299004464 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 743299004465 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743299004466 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 743299004467 Walker A/P-loop; other site 743299004468 ATP binding site [chemical binding]; other site 743299004469 Q-loop/lid; other site 743299004470 ABC transporter signature motif; other site 743299004471 Walker B; other site 743299004472 D-loop; other site 743299004473 H-loop/switch region; other site 743299004474 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 743299004475 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 743299004476 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 743299004477 MoxR-like ATPases [General function prediction only]; Region: COG0714 743299004478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299004479 ATP binding site [chemical binding]; other site 743299004480 Walker A motif; other site 743299004481 Walker B motif; other site 743299004482 arginine finger; other site 743299004483 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 743299004484 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743299004485 catalytic residue [active] 743299004486 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 743299004487 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743299004488 catalytic residue [active] 743299004489 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 743299004490 lipoyl attachment site [posttranslational modification]; other site 743299004491 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 743299004492 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 743299004493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 743299004494 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 743299004495 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 743299004496 MoaE homodimer interface [polypeptide binding]; other site 743299004497 MoaD interaction [polypeptide binding]; other site 743299004498 active site residues [active] 743299004499 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 743299004500 MoaE interaction surface [polypeptide binding]; other site 743299004501 MoeB interaction surface [polypeptide binding]; other site 743299004502 thiocarboxylated glycine; other site 743299004503 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 743299004504 putative inner membrane peptidase; Provisional; Region: PRK11778 743299004505 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 743299004506 tandem repeat interface [polypeptide binding]; other site 743299004507 oligomer interface [polypeptide binding]; other site 743299004508 active site residues [active] 743299004509 Protein of unknown function (DUF423); Region: DUF423; pfam04241 743299004510 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 743299004511 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 743299004512 putative NAD(P) binding site [chemical binding]; other site 743299004513 active site 743299004514 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 743299004515 Sel1 repeat; Region: Sel1; cl02723 743299004516 Sel1-like repeats; Region: SEL1; smart00671 743299004517 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 743299004518 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 743299004519 Ligand binding site; other site 743299004520 DXD motif; other site 743299004521 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 743299004522 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 743299004523 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 743299004524 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743299004525 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743299004526 Predicted integral membrane protein [Function unknown]; Region: COG5615 743299004527 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 743299004528 putative hydrolase; Provisional; Region: PRK11460 743299004529 PAS domain; Region: PAS_9; pfam13426 743299004530 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 743299004531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299004532 Walker A motif; other site 743299004533 ATP binding site [chemical binding]; other site 743299004534 Walker B motif; other site 743299004535 arginine finger; other site 743299004536 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 743299004537 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 743299004538 ThiC-associated domain; Region: ThiC-associated; pfam13667 743299004539 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 743299004540 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 743299004541 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 743299004542 Uncharacterized conserved protein [Function unknown]; Region: COG2361 743299004543 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 743299004544 active site 743299004545 NTP binding site [chemical binding]; other site 743299004546 metal binding triad [ion binding]; metal-binding site 743299004547 antibiotic binding site [chemical binding]; other site 743299004548 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 743299004549 KilA-N domain; Region: KilA-N; pfam04383 743299004550 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 743299004551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299004552 Walker A/P-loop; other site 743299004553 ATP binding site [chemical binding]; other site 743299004554 Q-loop/lid; other site 743299004555 ABC transporter signature motif; other site 743299004556 Walker B; other site 743299004557 D-loop; other site 743299004558 H-loop/switch region; other site 743299004559 ABC transporter; Region: ABC_tran_2; pfam12848 743299004560 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743299004561 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 743299004562 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 743299004563 active site 743299004564 substrate binding site [chemical binding]; other site 743299004565 metal binding site [ion binding]; metal-binding site 743299004566 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 743299004567 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299004568 ATP binding site [chemical binding]; other site 743299004569 putative Mg++ binding site [ion binding]; other site 743299004570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743299004571 nucleotide binding region [chemical binding]; other site 743299004572 ATP-binding site [chemical binding]; other site 743299004573 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 743299004574 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743299004575 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743299004576 catalytic residue [active] 743299004577 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 743299004578 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 743299004579 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 743299004580 FAD binding pocket [chemical binding]; other site 743299004581 FAD binding motif [chemical binding]; other site 743299004582 phosphate binding motif [ion binding]; other site 743299004583 beta-alpha-beta structure motif; other site 743299004584 NAD binding pocket [chemical binding]; other site 743299004585 Iron coordination center [ion binding]; other site 743299004586 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 743299004587 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 743299004588 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 743299004589 nickel binding site [ion binding]; other site 743299004590 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 743299004591 dimerization interface [polypeptide binding]; other site 743299004592 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 743299004593 ATP binding site [chemical binding]; other site 743299004594 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 743299004595 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 743299004596 HupF/HypC family; Region: HupF_HypC; pfam01455 743299004597 Acylphosphatase; Region: Acylphosphatase; pfam00708 743299004598 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 743299004599 HypF finger; Region: zf-HYPF; pfam07503 743299004600 HypF finger; Region: zf-HYPF; pfam07503 743299004601 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 743299004602 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 743299004603 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 743299004604 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 743299004605 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 743299004606 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 743299004607 motif 1; other site 743299004608 active site 743299004609 motif 2; other site 743299004610 motif 3; other site 743299004611 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 743299004612 DHHA1 domain; Region: DHHA1; pfam02272 743299004613 RecX family; Region: RecX; pfam02631 743299004614 recombinase A; Provisional; Region: recA; PRK09354 743299004615 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 743299004616 hexamer interface [polypeptide binding]; other site 743299004617 Walker A motif; other site 743299004618 ATP binding site [chemical binding]; other site 743299004619 Walker B motif; other site 743299004620 Competence-damaged protein; Region: CinA; pfam02464 743299004621 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 743299004622 tetramer interfaces [polypeptide binding]; other site 743299004623 binuclear metal-binding site [ion binding]; other site 743299004624 thiamine monophosphate kinase; Provisional; Region: PRK05731 743299004625 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 743299004626 ATP binding site [chemical binding]; other site 743299004627 dimerization interface [polypeptide binding]; other site 743299004628 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 743299004629 active site 743299004630 HIGH motif; other site 743299004631 nucleotide binding site [chemical binding]; other site 743299004632 KMSKS motif; other site 743299004633 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 743299004634 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 743299004635 active site 743299004636 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743299004637 PII uridylyl-transferase; Provisional; Region: PRK03059 743299004638 metal binding triad; other site 743299004639 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 743299004640 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743299004641 Zn2+ binding site [ion binding]; other site 743299004642 Mg2+ binding site [ion binding]; other site 743299004643 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 743299004644 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 743299004645 putative lysogenization regulator; Reviewed; Region: PRK00218 743299004646 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 743299004647 Fanconi anemia ID complex proteins FANCI and FANCD2; Region: FANC; cl17018 743299004648 ubiquitination site [posttranslational modification]; other site 743299004649 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299004650 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 743299004651 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 743299004652 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 743299004653 ResB-like family; Region: ResB; pfam05140 743299004654 Conjugal transfer protein TraD; Region: TraD; cl05753 743299004655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743299004656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 743299004657 phosphorylation site [posttranslational modification] 743299004658 dimer interface [polypeptide binding]; other site 743299004659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299004660 ATP binding site [chemical binding]; other site 743299004661 Mg2+ binding site [ion binding]; other site 743299004662 G-X-G motif; other site 743299004663 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 743299004664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299004665 active site 743299004666 phosphorylation site [posttranslational modification] 743299004667 intermolecular recognition site; other site 743299004668 dimerization interface [polypeptide binding]; other site 743299004669 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743299004670 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 743299004671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299004672 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743299004673 putative substrate translocation pore; other site 743299004674 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 743299004675 rusticyanin; Region: rusti_cyanin; TIGR03095 743299004676 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 743299004677 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cd00919 743299004678 D-pathway; other site 743299004679 Low-spin heme binding site [chemical binding]; other site 743299004680 Putative water exit pathway; other site 743299004681 Binuclear center (active site) [active] 743299004682 K-pathway; other site 743299004683 Putative proton exit pathway; other site 743299004684 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 743299004685 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 743299004686 Cytochrome c; Region: Cytochrom_C; cl11414 743299004687 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 743299004688 Cytochrome c; Region: Cytochrom_C; cl11414 743299004689 Protein of unknown function (DUF423); Region: DUF423; pfam04241 743299004690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 743299004691 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 743299004692 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 743299004693 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743299004694 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 743299004695 active site 743299004696 substrate binding pocket [chemical binding]; other site 743299004697 dimer interface [polypeptide binding]; other site 743299004698 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 743299004699 acid-resistance membrane protein; Provisional; Region: PRK10209 743299004700 Uncharacterized conserved protein [Function unknown]; Region: COG2128 743299004701 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 743299004702 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 743299004703 MarR family; Region: MarR_2; pfam12802 743299004704 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743299004705 active site 743299004706 DNA binding site [nucleotide binding] 743299004707 Int/Topo IB signature motif; other site 743299004708 ParB-like nuclease domain; Region: ParB; smart00470 743299004709 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 743299004710 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743299004711 P-loop; other site 743299004712 Magnesium ion binding site [ion binding]; other site 743299004713 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 743299004714 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 743299004715 VirB7 interaction site; other site 743299004716 VirB8 protein; Region: VirB8; cl01500 743299004717 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 743299004718 conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193 743299004719 Autotransporter beta-domain; Region: Autotransporter; smart00869 743299004720 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 743299004721 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 743299004722 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 743299004723 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 743299004724 TrbC/VIRB2 family; Region: TrbC; pfam04956 743299004725 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 743299004726 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 743299004727 ATP binding site [chemical binding]; other site 743299004728 Walker A motif; other site 743299004729 hexamer interface [polypeptide binding]; other site 743299004730 Walker B motif; other site 743299004731 DNA topoisomerase III; Provisional; Region: PRK07726 743299004732 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 743299004733 active site 743299004734 putative interdomain interaction site [polypeptide binding]; other site 743299004735 putative metal-binding site [ion binding]; other site 743299004736 putative nucleotide binding site [chemical binding]; other site 743299004737 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 743299004738 domain I; other site 743299004739 DNA binding groove [nucleotide binding] 743299004740 phosphate binding site [ion binding]; other site 743299004741 domain II; other site 743299004742 domain III; other site 743299004743 nucleotide binding site [chemical binding]; other site 743299004744 catalytic site [active] 743299004745 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 743299004746 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 743299004747 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 743299004748 active site 743299004749 substrate binding site [chemical binding]; other site 743299004750 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 743299004751 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 743299004752 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 743299004753 PemK-like protein; Region: PemK; cl00995 743299004754 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 743299004755 stationary phase growth adaptation protein; Provisional; Region: PRK09717 743299004756 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 743299004757 Active Sites [active] 743299004758 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 743299004759 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 743299004760 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 743299004761 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 743299004762 HEAT repeats; Region: HEAT_2; pfam13646 743299004763 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 743299004764 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 743299004765 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743299004766 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743299004767 catalytic residue [active] 743299004768 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 743299004769 Restriction endonuclease [Defense mechanisms]; Region: COG3587 743299004770 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 743299004771 DEAD/DEAH box helicase; Region: DEAD; pfam00270 743299004772 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 743299004773 DNA methylase; Region: N6_N4_Mtase; cl17433 743299004774 DNA methylase; Region: N6_N4_Mtase; pfam01555 743299004775 DNA methylase; Region: N6_N4_Mtase; cl17433 743299004776 SIR2-like domain; Region: SIR2_2; pfam13289 743299004777 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 743299004778 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 743299004779 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 743299004780 Double zinc ribbon; Region: DZR; pfam12773 743299004781 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299004782 ATP binding site [chemical binding]; other site 743299004783 putative Mg++ binding site [ion binding]; other site 743299004784 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 743299004785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743299004786 nucleotide binding region [chemical binding]; other site 743299004787 ATP-binding site [chemical binding]; other site 743299004788 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 743299004789 G1 box; other site 743299004790 GTP/Mg2+ binding site [chemical binding]; other site 743299004791 G2 box; other site 743299004792 Switch I region; other site 743299004793 G3 box; other site 743299004794 Switch II region; other site 743299004795 G4 box; other site 743299004796 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743299004797 IHF - DNA interface [nucleotide binding]; other site 743299004798 IHF dimer interface [polypeptide binding]; other site 743299004799 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743299004800 IHF - DNA interface [nucleotide binding]; other site 743299004801 IHF dimer interface [polypeptide binding]; other site 743299004802 Predicted transcriptional regulator [Transcription]; Region: COG3905 743299004803 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 743299004804 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743299004805 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743299004806 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 743299004807 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 743299004808 Probable transposase; Region: OrfB_IS605; pfam01385 743299004809 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 743299004810 Protein of unknown function (DUF1614); Region: DUF1614; cl15407 743299004811 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 743299004812 Sel1 repeat; Region: Sel1; cl02723 743299004813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 743299004814 Transposase; Region: DDE_Tnp_ISL3; pfam01610 743299004815 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 743299004816 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 743299004817 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 743299004818 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 743299004819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 743299004820 Homeodomain-like domain; Region: HTH_23; cl17451 743299004821 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 743299004822 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 743299004823 Zn binding sites [ion binding]; other site 743299004824 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743299004825 Phosphate acyltransferases; Region: PlsC; smart00563 743299004826 putative acyl-acceptor binding pocket; other site 743299004827 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 743299004828 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299004829 Walker A motif; other site 743299004830 ATP binding site [chemical binding]; other site 743299004831 Walker B motif; other site 743299004832 ParB-like nuclease domain; Region: ParBc; pfam02195 743299004833 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 743299004834 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 743299004835 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 743299004836 Active Sites [active] 743299004837 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 743299004838 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 743299004839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299004840 ATP binding site [chemical binding]; other site 743299004841 putative Mg++ binding site [ion binding]; other site 743299004842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743299004843 nucleotide binding region [chemical binding]; other site 743299004844 ATP-binding site [chemical binding]; other site 743299004845 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 743299004846 NlpC/P60 family; Region: NLPC_P60; pfam00877 743299004847 Transglycosylase SLT domain; Region: SLT_2; pfam13406 743299004848 murein hydrolase B; Provisional; Region: PRK10760; cl17906 743299004849 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 743299004850 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 743299004851 active site 743299004852 putative substrate binding pocket [chemical binding]; other site 743299004853 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 743299004854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299004855 S-adenosylmethionine binding site [chemical binding]; other site 743299004856 phosphoglycolate phosphatase; Provisional; Region: PRK13222 743299004857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299004858 motif II; other site 743299004859 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 743299004860 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 743299004861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743299004862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299004863 homodimer interface [polypeptide binding]; other site 743299004864 catalytic residue [active] 743299004865 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 743299004866 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 743299004867 trimer interface [polypeptide binding]; other site 743299004868 active site 743299004869 substrate binding site [chemical binding]; other site 743299004870 CoA binding site [chemical binding]; other site 743299004871 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 743299004872 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 743299004873 metal binding site [ion binding]; metal-binding site 743299004874 dimer interface [polypeptide binding]; other site 743299004875 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 743299004876 rare lipoprotein A; Region: rlpA; TIGR00413 743299004877 Sporulation related domain; Region: SPOR; pfam05036 743299004878 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 743299004879 phosphoenolpyruvate synthase; Validated; Region: PRK06464 743299004880 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 743299004881 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 743299004882 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 743299004883 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 743299004884 phosphoglyceromutase; Provisional; Region: PRK05434 743299004885 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 743299004886 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743299004887 E3 interaction surface; other site 743299004888 lipoyl attachment site [posttranslational modification]; other site 743299004889 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 743299004890 Acetokinase family; Region: Acetate_kinase; cl17229 743299004891 propionate/acetate kinase; Provisional; Region: PRK12379 743299004892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299004893 putative substrate translocation pore; other site 743299004894 cation transport protein; Region: 2A0119; TIGR00898 743299004895 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 743299004896 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 743299004897 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 743299004898 putative substrate binding site [chemical binding]; other site 743299004899 putative ATP binding site [chemical binding]; other site 743299004900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 743299004901 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743299004902 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743299004903 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 743299004904 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 743299004905 putative active site; other site 743299004906 catalytic residue [active] 743299004907 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 743299004908 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 743299004909 substrate binding pocket [chemical binding]; other site 743299004910 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743299004911 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 743299004912 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 743299004913 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 743299004914 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 743299004915 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743299004916 minor groove reading motif; other site 743299004917 helix-hairpin-helix signature motif; other site 743299004918 substrate binding pocket [chemical binding]; other site 743299004919 active site 743299004920 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 743299004921 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743299004922 RNA binding surface [nucleotide binding]; other site 743299004923 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 743299004924 probable active site [active] 743299004925 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 743299004926 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 743299004927 ScpA/B protein; Region: ScpA_ScpB; cl00598 743299004928 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 743299004929 active site 743299004930 HIGH motif; other site 743299004931 dimer interface [polypeptide binding]; other site 743299004932 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743299004933 active site 743299004934 KMSKS motif; other site 743299004935 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 743299004936 Peptidase family M50; Region: Peptidase_M50; pfam02163 743299004937 active site 743299004938 putative substrate binding region [chemical binding]; other site 743299004939 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 743299004940 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 743299004941 dinuclear metal binding motif [ion binding]; other site 743299004942 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743299004943 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743299004944 gamma-glutamyl kinase; Provisional; Region: PRK05429 743299004945 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 743299004946 nucleotide binding site [chemical binding]; other site 743299004947 homotetrameric interface [polypeptide binding]; other site 743299004948 putative phosphate binding site [ion binding]; other site 743299004949 putative allosteric binding site; other site 743299004950 PUA domain; Region: PUA; pfam01472 743299004951 GMP synthase; Reviewed; Region: guaA; PRK00074 743299004952 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 743299004953 AMP/PPi binding site [chemical binding]; other site 743299004954 candidate oxyanion hole; other site 743299004955 catalytic triad [active] 743299004956 potential glutamine specificity residues [chemical binding]; other site 743299004957 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 743299004958 ATP Binding subdomain [chemical binding]; other site 743299004959 Ligand Binding sites [chemical binding]; other site 743299004960 Dimerization subdomain; other site 743299004961 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 743299004962 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 743299004963 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 743299004964 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 743299004965 active site 743299004966 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 743299004967 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 743299004968 Ligand binding site; other site 743299004969 Putative Catalytic site; other site 743299004970 DXD motif; other site 743299004971 poly(A) polymerase; Region: pcnB; TIGR01942 743299004972 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 743299004973 active site 743299004974 NTP binding site [chemical binding]; other site 743299004975 metal binding triad [ion binding]; metal-binding site 743299004976 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 743299004977 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 743299004978 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 743299004979 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 743299004980 active site 743299004981 NTP binding site [chemical binding]; other site 743299004982 metal binding triad [ion binding]; metal-binding site 743299004983 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 743299004984 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 743299004985 catalytic center binding site [active] 743299004986 ATP binding site [chemical binding]; other site 743299004987 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 743299004988 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 743299004989 Substrate-binding site [chemical binding]; other site 743299004990 Substrate specificity [chemical binding]; other site 743299004991 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 743299004992 oligomerization interface [polypeptide binding]; other site 743299004993 active site 743299004994 metal binding site [ion binding]; metal-binding site 743299004995 pantoate--beta-alanine ligase; Region: panC; TIGR00018 743299004996 Pantoate-beta-alanine ligase; Region: PanC; cd00560 743299004997 active site 743299004998 ATP-binding site [chemical binding]; other site 743299004999 pantoate-binding site; other site 743299005000 HXXH motif; other site 743299005001 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 743299005002 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 743299005003 FAD binding domain; Region: FAD_binding_4; pfam01565 743299005004 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 743299005005 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 743299005006 Cysteine-rich domain; Region: CCG; pfam02754 743299005007 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 743299005008 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 743299005009 Smr domain; Region: Smr; pfam01713 743299005010 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 743299005011 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 743299005012 exodeoxyribonuclease X; Provisional; Region: PRK07983 743299005013 active site 743299005014 catalytic site [active] 743299005015 substrate binding site [chemical binding]; other site 743299005016 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 743299005017 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 743299005018 YccA-like proteins; Region: YccA_like; cd10433 743299005019 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 743299005020 MutS domain I; Region: MutS_I; pfam01624 743299005021 MutS domain II; Region: MutS_II; pfam05188 743299005022 MutS domain III; Region: MutS_III; pfam05192 743299005023 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 743299005024 Walker A/P-loop; other site 743299005025 ATP binding site [chemical binding]; other site 743299005026 Q-loop/lid; other site 743299005027 ABC transporter signature motif; other site 743299005028 Walker B; other site 743299005029 D-loop; other site 743299005030 H-loop/switch region; other site 743299005031 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 743299005032 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 743299005033 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 743299005034 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 743299005035 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 743299005036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743299005037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743299005038 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743299005039 dimerization interface [polypeptide binding]; other site 743299005040 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 743299005041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299005042 putative substrate translocation pore; other site 743299005043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299005044 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 743299005045 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 743299005046 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 743299005047 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299005048 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 743299005049 heme-binding site [chemical binding]; other site 743299005050 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 743299005051 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743299005052 catalytic loop [active] 743299005053 iron binding site [ion binding]; other site 743299005054 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 743299005055 FAD binding pocket [chemical binding]; other site 743299005056 FAD binding motif [chemical binding]; other site 743299005057 phosphate binding motif [ion binding]; other site 743299005058 beta-alpha-beta structure motif; other site 743299005059 NAD binding pocket [chemical binding]; other site 743299005060 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 743299005061 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 743299005062 glycine cleavage system protein H; Provisional; Region: PRK13380 743299005063 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 743299005064 lipoyl attachment site [posttranslational modification]; other site 743299005065 Protein of unknown function, DUF488; Region: DUF488; cl01246 743299005066 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 743299005067 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743299005068 ligand binding site [chemical binding]; other site 743299005069 flexible hinge region; other site 743299005070 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 743299005071 putative switch regulator; other site 743299005072 non-specific DNA interactions [nucleotide binding]; other site 743299005073 DNA binding site [nucleotide binding] 743299005074 sequence specific DNA binding site [nucleotide binding]; other site 743299005075 putative cAMP binding site [chemical binding]; other site 743299005076 NMT1-like family; Region: NMT1_2; pfam13379 743299005077 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 743299005078 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 743299005079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299005080 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 743299005081 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743299005082 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 743299005083 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 743299005084 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743299005085 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 743299005086 [2Fe-2S] cluster binding site [ion binding]; other site 743299005087 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 743299005088 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 743299005089 [4Fe-4S] binding site [ion binding]; other site 743299005090 molybdopterin cofactor binding site; other site 743299005091 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 743299005092 molybdopterin cofactor binding site; other site 743299005093 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 743299005094 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 743299005095 glycosyl transferase family protein; Provisional; Region: PRK08136 743299005096 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 743299005097 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 743299005098 active site 743299005099 SAM binding site [chemical binding]; other site 743299005100 homodimer interface [polypeptide binding]; other site 743299005101 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 743299005102 putative active site [active] 743299005103 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 743299005104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299005105 active site 743299005106 phosphorylation site [posttranslational modification] 743299005107 intermolecular recognition site; other site 743299005108 dimerization interface [polypeptide binding]; other site 743299005109 ANTAR domain; Region: ANTAR; pfam03861 743299005110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 743299005111 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 743299005112 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743299005113 cardiolipin synthase 2; Provisional; Region: PRK11263 743299005114 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 743299005115 putative active site [active] 743299005116 catalytic site [active] 743299005117 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 743299005118 putative active site [active] 743299005119 catalytic site [active] 743299005120 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299005121 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299005122 metal binding site [ion binding]; metal-binding site 743299005123 active site 743299005124 I-site; other site 743299005125 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299005126 circadian clock protein KaiC; Reviewed; Region: PRK09302 743299005127 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299005128 Walker A motif; other site 743299005129 ATP binding site [chemical binding]; other site 743299005130 Walker B motif; other site 743299005131 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299005132 Walker A motif; other site 743299005133 Walker A motif; other site 743299005134 ATP binding site [chemical binding]; other site 743299005135 Walker B motif; other site 743299005136 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 743299005137 amphipathic channel; other site 743299005138 Asn-Pro-Ala signature motifs; other site 743299005139 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 743299005140 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 743299005141 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 743299005142 catalytic residue [active] 743299005143 putative FPP diphosphate binding site; other site 743299005144 putative FPP binding hydrophobic cleft; other site 743299005145 dimer interface [polypeptide binding]; other site 743299005146 putative IPP diphosphate binding site; other site 743299005147 CsbD-like; Region: CsbD; pfam05532 743299005148 PRC-barrel domain; Region: PRC; pfam05239 743299005149 BON domain; Region: BON; pfam04972 743299005150 PRC-barrel domain; Region: PRC; pfam05239 743299005151 UDP-glycosyltransferase; Region: PLN02534 743299005152 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 743299005153 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 743299005154 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 743299005155 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 743299005156 putative ion selectivity filter; other site 743299005157 putative pore gating glutamate residue; other site 743299005158 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 743299005159 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 743299005160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743299005161 non-specific DNA binding site [nucleotide binding]; other site 743299005162 salt bridge; other site 743299005163 sequence-specific DNA binding site [nucleotide binding]; other site 743299005164 Pirin-related protein [General function prediction only]; Region: COG1741 743299005165 Pirin; Region: Pirin; pfam02678 743299005166 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 743299005167 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743299005168 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743299005169 catalytic residue [active] 743299005170 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 743299005171 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 743299005172 CAP-like domain; other site 743299005173 active site 743299005174 primary dimer interface [polypeptide binding]; other site 743299005175 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 743299005176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299005177 ATP binding site [chemical binding]; other site 743299005178 Mg2+ binding site [ion binding]; other site 743299005179 G-X-G motif; other site 743299005180 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 743299005181 anchoring element; other site 743299005182 dimer interface [polypeptide binding]; other site 743299005183 ATP binding site [chemical binding]; other site 743299005184 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 743299005185 active site 743299005186 putative metal-binding site [ion binding]; other site 743299005187 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 743299005188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743299005189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743299005190 DNA binding site [nucleotide binding] 743299005191 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743299005192 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743299005193 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299005194 Outer membrane efflux protein; Region: OEP; pfam02321 743299005195 Outer membrane efflux protein; Region: OEP; pfam02321 743299005196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743299005197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299005198 dimer interface [polypeptide binding]; other site 743299005199 phosphorylation site [posttranslational modification] 743299005200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299005201 ATP binding site [chemical binding]; other site 743299005202 Mg2+ binding site [ion binding]; other site 743299005203 G-X-G motif; other site 743299005204 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743299005205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299005206 active site 743299005207 phosphorylation site [posttranslational modification] 743299005208 intermolecular recognition site; other site 743299005209 dimerization interface [polypeptide binding]; other site 743299005210 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743299005211 DNA binding site [nucleotide binding] 743299005212 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 743299005213 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743299005214 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743299005215 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 743299005216 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 743299005217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299005218 active site 743299005219 phosphorylation site [posttranslational modification] 743299005220 intermolecular recognition site; other site 743299005221 dimerization interface [polypeptide binding]; other site 743299005222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743299005223 DNA binding site [nucleotide binding] 743299005224 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 743299005225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743299005226 dimerization interface [polypeptide binding]; other site 743299005227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299005228 dimer interface [polypeptide binding]; other site 743299005229 phosphorylation site [posttranslational modification] 743299005230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299005231 ATP binding site [chemical binding]; other site 743299005232 G-X-G motif; other site 743299005233 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 743299005234 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743299005235 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299005236 putative membrane fusion protein; Region: TIGR02828 743299005237 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743299005238 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 743299005239 EamA-like transporter family; Region: EamA; pfam00892 743299005240 Outer membrane efflux protein; Region: OEP; pfam02321 743299005241 Outer membrane efflux protein; Region: OEP; pfam02321 743299005242 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 743299005243 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743299005244 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299005245 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 743299005246 pyruvate kinase; Provisional; Region: PRK14725 743299005247 active site 743299005248 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 743299005249 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 743299005250 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 743299005251 ketol-acid reductoisomerase; Provisional; Region: PRK05479 743299005252 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 743299005253 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 743299005254 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 743299005255 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 743299005256 putative valine binding site [chemical binding]; other site 743299005257 dimer interface [polypeptide binding]; other site 743299005258 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 743299005259 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 743299005260 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 743299005261 PYR/PP interface [polypeptide binding]; other site 743299005262 dimer interface [polypeptide binding]; other site 743299005263 TPP binding site [chemical binding]; other site 743299005264 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 743299005265 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 743299005266 TPP-binding site [chemical binding]; other site 743299005267 dimer interface [polypeptide binding]; other site 743299005268 MutS domain III; Region: MutS_III; pfam05192 743299005269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299005270 Walker A/P-loop; other site 743299005271 ATP binding site [chemical binding]; other site 743299005272 Q-loop/lid; other site 743299005273 ABC transporter signature motif; other site 743299005274 Walker B; other site 743299005275 D-loop; other site 743299005276 H-loop/switch region; other site 743299005277 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 743299005278 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 743299005279 nucleoside/Zn binding site; other site 743299005280 dimer interface [polypeptide binding]; other site 743299005281 catalytic motif [active] 743299005282 Competence protein A; Region: Competence_A; pfam11104 743299005283 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 743299005284 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 743299005285 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 743299005286 Pilus assembly protein, PilO; Region: PilO; pfam04350 743299005287 Pilus assembly protein, PilP; Region: PilP; pfam04351 743299005288 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 743299005289 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 743299005290 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 743299005291 shikimate kinase; Reviewed; Region: aroK; PRK00131 743299005292 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 743299005293 ADP binding site [chemical binding]; other site 743299005294 magnesium binding site [ion binding]; other site 743299005295 putative shikimate binding site; other site 743299005296 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 743299005297 active site 743299005298 dimer interface [polypeptide binding]; other site 743299005299 metal binding site [ion binding]; metal-binding site 743299005300 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 743299005301 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 743299005302 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743299005303 Zn2+ binding site [ion binding]; other site 743299005304 Mg2+ binding site [ion binding]; other site 743299005305 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 743299005306 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 743299005307 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 743299005308 active site 743299005309 dimer interface [polypeptide binding]; other site 743299005310 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 743299005311 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 743299005312 active site 743299005313 FMN binding site [chemical binding]; other site 743299005314 substrate binding site [chemical binding]; other site 743299005315 3Fe-4S cluster binding site [ion binding]; other site 743299005316 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 743299005317 domain interface; other site 743299005318 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 743299005319 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743299005320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743299005321 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 743299005322 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 743299005323 substrate binding site [chemical binding]; other site 743299005324 active site 743299005325 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743299005326 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743299005327 putative acyl-acceptor binding pocket; other site 743299005328 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 743299005329 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 743299005330 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 743299005331 threonine dehydratase; Reviewed; Region: PRK09224 743299005332 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 743299005333 tetramer interface [polypeptide binding]; other site 743299005334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299005335 catalytic residue [active] 743299005336 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 743299005337 putative Ile/Val binding site [chemical binding]; other site 743299005338 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 743299005339 putative Ile/Val binding site [chemical binding]; other site 743299005340 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 743299005341 AAA domain; Region: AAA_23; pfam13476 743299005342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299005343 Walker A/P-loop; other site 743299005344 ATP binding site [chemical binding]; other site 743299005345 Restriction endonuclease; Region: Mrr_cat; pfam04471 743299005346 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 743299005347 DNA methylase; Region: N6_N4_Mtase; pfam01555 743299005348 DNA methylase; Region: N6_N4_Mtase; pfam01555 743299005349 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 743299005350 BRO family, N-terminal domain; Region: Bro-N; pfam02498 743299005351 Putative addiction module component; Region: Unstab_antitox; pfam09720 743299005352 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 743299005353 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 743299005354 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 743299005355 Protein export membrane protein; Region: SecD_SecF; pfam02355 743299005356 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 743299005357 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 743299005358 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 743299005359 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 743299005360 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 743299005361 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 743299005362 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 743299005363 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 743299005364 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 743299005365 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 743299005366 Domain of unknown function DUF21; Region: DUF21; pfam01595 743299005367 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 743299005368 Transporter associated domain; Region: CorC_HlyC; smart01091 743299005369 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 743299005370 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 743299005371 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 743299005372 homodimer interface [polypeptide binding]; other site 743299005373 substrate-cofactor binding pocket; other site 743299005374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299005375 catalytic residue [active] 743299005376 amidophosphoribosyltransferase; Provisional; Region: PRK09123 743299005377 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 743299005378 active site 743299005379 tetramer interface [polypeptide binding]; other site 743299005380 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743299005381 active site 743299005382 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 743299005383 Colicin V production protein; Region: Colicin_V; pfam02674 743299005384 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 743299005385 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 743299005386 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743299005387 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 743299005388 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 743299005389 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 743299005390 substrate binding site [chemical binding]; other site 743299005391 active site 743299005392 catalytic residues [active] 743299005393 heterodimer interface [polypeptide binding]; other site 743299005394 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 743299005395 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 743299005396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299005397 catalytic residue [active] 743299005398 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 743299005399 active site 743299005400 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 743299005401 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 743299005402 dimerization interface 3.5A [polypeptide binding]; other site 743299005403 active site 743299005404 FimV N-terminal domain; Region: FimV_core; TIGR03505 743299005405 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 743299005406 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 743299005407 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 743299005408 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 743299005409 tartrate dehydrogenase; Region: TTC; TIGR02089 743299005410 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 743299005411 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 743299005412 GTP binding site; other site 743299005413 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 743299005414 Walker A motif; other site 743299005415 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 743299005416 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 743299005417 dimer interface [polypeptide binding]; other site 743299005418 putative functional site; other site 743299005419 putative MPT binding site; other site 743299005420 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 743299005421 PLD-like domain; Region: PLDc_2; pfam13091 743299005422 putative active site [active] 743299005423 catalytic site [active] 743299005424 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 743299005425 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 743299005426 AMMECR1; Region: AMMECR1; pfam01871 743299005427 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 743299005428 putative ligand binding pocket/active site [active] 743299005429 putative metal binding site [ion binding]; other site 743299005430 arsenical pump membrane protein; Provisional; Region: PRK15445 743299005431 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 743299005432 transmembrane helices; other site 743299005433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743299005434 dimerization interface [polypeptide binding]; other site 743299005435 putative DNA binding site [nucleotide binding]; other site 743299005436 putative Zn2+ binding site [ion binding]; other site 743299005437 HAMP domain; Region: HAMP; pfam00672 743299005438 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 743299005439 Domain of unknown function DUF20; Region: UPF0118; pfam01594 743299005440 protoporphyrinogen oxidase; Region: PLN02576 743299005441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743299005442 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 743299005443 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 743299005444 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 743299005445 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 743299005446 ssDNA binding site; other site 743299005447 generic binding surface II; other site 743299005448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299005449 ATP binding site [chemical binding]; other site 743299005450 putative Mg++ binding site [ion binding]; other site 743299005451 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743299005452 nucleotide binding region [chemical binding]; other site 743299005453 ATP-binding site [chemical binding]; other site 743299005454 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 743299005455 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 743299005456 homotrimer interaction site [polypeptide binding]; other site 743299005457 putative active site [active] 743299005458 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 743299005459 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743299005460 Zn2+ binding site [ion binding]; other site 743299005461 Mg2+ binding site [ion binding]; other site 743299005462 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 743299005463 synthetase active site [active] 743299005464 NTP binding site [chemical binding]; other site 743299005465 metal binding site [ion binding]; metal-binding site 743299005466 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 743299005467 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 743299005468 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 743299005469 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 743299005470 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 743299005471 catalytic site [active] 743299005472 G-X2-G-X-G-K; other site 743299005473 hypothetical protein; Provisional; Region: PRK11820 743299005474 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 743299005475 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 743299005476 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 743299005477 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743299005478 catalytic residues [active] 743299005479 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 743299005480 metal ion-dependent adhesion site (MIDAS); other site 743299005481 MoxR-like ATPases [General function prediction only]; Region: COG0714 743299005482 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 743299005483 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 743299005484 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 743299005485 multimerization interface [polypeptide binding]; other site 743299005486 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 743299005487 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 743299005488 dimer interface [polypeptide binding]; other site 743299005489 catalytic residue [active] 743299005490 metal binding site [ion binding]; metal-binding site 743299005491 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 743299005492 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743299005493 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299005494 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 743299005495 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 743299005496 Walker A/P-loop; other site 743299005497 ATP binding site [chemical binding]; other site 743299005498 Q-loop/lid; other site 743299005499 ABC transporter signature motif; other site 743299005500 Walker B; other site 743299005501 D-loop; other site 743299005502 H-loop/switch region; other site 743299005503 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 743299005504 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 743299005505 Walker A/P-loop; other site 743299005506 ATP binding site [chemical binding]; other site 743299005507 Q-loop/lid; other site 743299005508 ABC transporter signature motif; other site 743299005509 Walker B; other site 743299005510 D-loop; other site 743299005511 H-loop/switch region; other site 743299005512 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 743299005513 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 743299005514 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 743299005515 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 743299005516 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743299005517 IHF - DNA interface [nucleotide binding]; other site 743299005518 IHF dimer interface [polypeptide binding]; other site 743299005519 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 743299005520 HsdM N-terminal domain; Region: HsdM_N; pfam12161 743299005521 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 743299005522 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 743299005523 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 743299005524 oligomeric interface; other site 743299005525 putative active site [active] 743299005526 homodimer interface [polypeptide binding]; other site 743299005527 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 743299005528 Mrr N-terminal domain; Region: Mrr_N; pfam14338 743299005529 Restriction endonuclease; Region: Mrr_cat; pfam04471 743299005530 SIR2-like domain; Region: SIR2_2; pfam13289 743299005531 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 743299005532 HsdM N-terminal domain; Region: HsdM_N; pfam12161 743299005533 Methyltransferase domain; Region: Methyltransf_26; pfam13659 743299005534 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 743299005535 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 743299005536 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 743299005537 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 743299005538 Helix-turn-helix domain; Region: HTH_37; pfam13744 743299005539 non-specific DNA binding site [nucleotide binding]; other site 743299005540 salt bridge; other site 743299005541 sequence-specific DNA binding site [nucleotide binding]; other site 743299005542 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 743299005543 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 743299005544 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 743299005545 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 743299005546 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299005547 ATP binding site [chemical binding]; other site 743299005548 putative Mg++ binding site [ion binding]; other site 743299005549 Protein of unknown function DUF45; Region: DUF45; pfam01863 743299005550 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 743299005551 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 743299005552 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 743299005553 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 743299005554 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 743299005555 integral membrane protein MviN; Region: mviN; TIGR01695 743299005556 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 743299005557 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 743299005558 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 743299005559 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 743299005560 active site 743299005561 Riboflavin kinase; Region: Flavokinase; smart00904 743299005562 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 743299005563 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743299005564 active site 743299005565 HIGH motif; other site 743299005566 nucleotide binding site [chemical binding]; other site 743299005567 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 743299005568 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 743299005569 active site 743299005570 KMSKS motif; other site 743299005571 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 743299005572 tRNA binding surface [nucleotide binding]; other site 743299005573 anticodon binding site; other site 743299005574 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 743299005575 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 743299005576 lipoprotein signal peptidase; Provisional; Region: PRK14787 743299005577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299005578 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 743299005579 NAD(P) binding site [chemical binding]; other site 743299005580 active site 743299005581 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 743299005582 putative catalytic residue [active] 743299005583 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 743299005584 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 743299005585 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 743299005586 DsrE/DsrF-like family; Region: DrsE; pfam02635 743299005587 nitrilase; Region: PLN02798 743299005588 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 743299005589 putative active site [active] 743299005590 catalytic triad [active] 743299005591 dimer interface [polypeptide binding]; other site 743299005592 TIGR02099 family protein; Region: TIGR02099 743299005593 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 743299005594 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 743299005595 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743299005596 metal binding triad; other site 743299005597 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 743299005598 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743299005599 metal binding triad; other site 743299005600 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 743299005601 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 743299005602 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 743299005603 homodimer interface [polypeptide binding]; other site 743299005604 substrate-cofactor binding pocket; other site 743299005605 catalytic residue [active] 743299005606 Zinc-finger domain; Region: zf-CHCC; cl01821 743299005607 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 743299005608 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 743299005609 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 743299005610 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 743299005611 DsbD alpha interface [polypeptide binding]; other site 743299005612 catalytic residues [active] 743299005613 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743299005614 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 743299005615 oligomerisation interface [polypeptide binding]; other site 743299005616 mobile loop; other site 743299005617 roof hairpin; other site 743299005618 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 743299005619 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 743299005620 ring oligomerisation interface [polypeptide binding]; other site 743299005621 ATP/Mg binding site [chemical binding]; other site 743299005622 stacking interactions; other site 743299005623 hinge regions; other site 743299005624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 743299005625 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743299005626 active site 743299005627 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 743299005628 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743299005629 active site 743299005630 nucleotide binding site [chemical binding]; other site 743299005631 HIGH motif; other site 743299005632 KMSKS motif; other site 743299005633 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 743299005634 ligand-binding site [chemical binding]; other site 743299005635 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 743299005636 Domain of unknown function (DUF814); Region: DUF814; pfam05670 743299005637 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 743299005638 DNA binding residues [nucleotide binding] 743299005639 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 743299005640 dimer interface [polypeptide binding]; other site 743299005641 mercury binding site [ion binding]; other site 743299005642 putative mercuric reductase; Provisional; Region: PRK13748 743299005643 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743299005644 metal-binding site [ion binding] 743299005645 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743299005646 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743299005647 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 743299005648 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 743299005649 putative molybdopterin cofactor binding site [chemical binding]; other site 743299005650 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 743299005651 putative molybdopterin cofactor binding site; other site 743299005652 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 743299005653 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 743299005654 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 743299005655 substrate binding site [chemical binding]; other site 743299005656 catalytic Zn binding site [ion binding]; other site 743299005657 NAD binding site [chemical binding]; other site 743299005658 structural Zn binding site [ion binding]; other site 743299005659 dimer interface [polypeptide binding]; other site 743299005660 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 743299005661 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 743299005662 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 743299005663 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 743299005664 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 743299005665 putative active site [active] 743299005666 putative NTP binding site [chemical binding]; other site 743299005667 putative nucleic acid binding site [nucleotide binding]; other site 743299005668 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 743299005669 Transposase; Region: HTH_Tnp_1; cl17663 743299005670 putative transposase OrfB; Reviewed; Region: PHA02517 743299005671 HTH-like domain; Region: HTH_21; pfam13276 743299005672 Integrase core domain; Region: rve; pfam00665 743299005673 Integrase core domain; Region: rve_3; pfam13683 743299005674 Protein of unknown function DUF262; Region: DUF262; pfam03235 743299005675 Uncharacterized conserved protein [Function unknown]; Region: COG1479 743299005676 Protein of unknown function DUF262; Region: DUF262; pfam03235 743299005677 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 743299005678 AAA domain; Region: AAA_11; pfam13086 743299005679 Part of AAA domain; Region: AAA_19; pfam13245 743299005680 AAA domain; Region: AAA_11; pfam13086 743299005681 AAA domain; Region: AAA_12; pfam13087 743299005682 PIN domain; Region: PIN_Smg5-Smg6-like; cd09880 743299005683 putative active site [active] 743299005684 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 743299005685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299005686 Walker A motif; other site 743299005687 ATP binding site [chemical binding]; other site 743299005688 Walker B motif; other site 743299005689 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 743299005690 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 743299005691 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 743299005692 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 743299005693 histidinol-phosphatase; Provisional; Region: PRK07328 743299005694 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 743299005695 active site 743299005696 dimer interface [polypeptide binding]; other site 743299005697 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 743299005698 Integrase core domain; Region: rve; pfam00665 743299005699 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 743299005700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299005701 Walker A motif; other site 743299005702 ATP binding site [chemical binding]; other site 743299005703 Walker B motif; other site 743299005704 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 743299005705 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 743299005706 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 743299005707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 743299005708 Transposase; Region: DDE_Tnp_ISL3; pfam01610 743299005709 Transposase [DNA replication, recombination, and repair]; Region: COG5421 743299005710 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 743299005711 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 743299005712 putative active site [active] 743299005713 putative NTP binding site [chemical binding]; other site 743299005714 putative nucleic acid binding site [nucleotide binding]; other site 743299005715 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 743299005716 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 743299005717 Methyltransferase domain; Region: Methyltransf_26; pfam13659 743299005718 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 743299005719 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 743299005720 oligomeric interface; other site 743299005721 putative active site [active] 743299005722 homodimer interface [polypeptide binding]; other site 743299005723 Winged helix-turn helix; Region: HTH_29; pfam13551 743299005724 Homeodomain-like domain; Region: HTH_32; pfam13565 743299005725 Integrase core domain; Region: rve; pfam00665 743299005726 Integrase core domain; Region: rve_3; pfam13683 743299005727 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 743299005728 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743299005729 active site 743299005730 DNA binding site [nucleotide binding] 743299005731 Int/Topo IB signature motif; other site 743299005732 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 743299005733 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 743299005734 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 743299005735 putative NAD(P) binding site [chemical binding]; other site 743299005736 putative substrate binding site [chemical binding]; other site 743299005737 catalytic Zn binding site [ion binding]; other site 743299005738 structural Zn binding site [ion binding]; other site 743299005739 dimer interface [polypeptide binding]; other site 743299005740 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 743299005741 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 743299005742 [2Fe-2S] cluster binding site [ion binding]; other site 743299005743 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 743299005744 hydrophobic ligand binding site; other site 743299005745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 743299005746 Creatinine amidohydrolase; Region: Creatininase; pfam02633 743299005747 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 743299005748 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743299005749 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743299005750 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 743299005751 dimer interface [polypeptide binding]; other site 743299005752 active site 743299005753 metal binding site [ion binding]; metal-binding site 743299005754 glutathione binding site [chemical binding]; other site 743299005755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 743299005756 Transposase; Region: DEDD_Tnp_IS110; pfam01548 743299005757 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 743299005758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299005759 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743299005760 NAD(P) binding site [chemical binding]; other site 743299005761 active site 743299005762 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 743299005763 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 743299005764 [2Fe-2S] cluster binding site [ion binding]; other site 743299005765 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 743299005766 hydrophobic ligand binding site; other site 743299005767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 743299005768 Transposase; Region: DEDD_Tnp_IS110; pfam01548 743299005769 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 743299005770 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 743299005771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 743299005772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299005773 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 743299005774 NAD(P) binding site [chemical binding]; other site 743299005775 active site 743299005776 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743299005777 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 743299005778 FAD binding pocket [chemical binding]; other site 743299005779 conserved FAD binding motif [chemical binding]; other site 743299005780 phosphate binding motif [ion binding]; other site 743299005781 beta-alpha-beta structure motif; other site 743299005782 NAD binding pocket [chemical binding]; other site 743299005783 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743299005784 catalytic loop [active] 743299005785 iron binding site [ion binding]; other site 743299005786 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 743299005787 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743299005788 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 743299005789 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 743299005790 Transposase; Region: DEDD_Tnp_IS110; pfam01548 743299005791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 743299005792 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 743299005793 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 743299005794 Integrase; Region: Integrase_1; pfam12835 743299005795 exonuclease subunit SbcC; Provisional; Region: PRK10246 743299005796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299005797 Walker A/P-loop; other site 743299005798 ATP binding site [chemical binding]; other site 743299005799 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 743299005800 ABC transporter signature motif; other site 743299005801 Walker B; other site 743299005802 D-loop; other site 743299005803 H-loop/switch region; other site 743299005804 exonuclease subunit SbcD; Provisional; Region: PRK10966 743299005805 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 743299005806 active site 743299005807 metal binding site [ion binding]; metal-binding site 743299005808 DNA binding site [nucleotide binding] 743299005809 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 743299005810 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 743299005811 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 743299005812 Methyltransferase domain; Region: Methyltransf_26; pfam13659 743299005813 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 743299005814 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 743299005815 Divergent AAA domain; Region: AAA_4; pfam04326 743299005816 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 743299005817 Predicted ATPase [General function prediction only]; Region: COG4637 743299005818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299005819 Walker A/P-loop; other site 743299005820 ATP binding site [chemical binding]; other site 743299005821 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 743299005822 TIGR02687 family protein; Region: TIGR02687 743299005823 PglZ domain; Region: PglZ; pfam08665 743299005824 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 743299005825 MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685 743299005826 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 743299005827 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743299005828 active site 743299005829 DNA binding site [nucleotide binding] 743299005830 Int/Topo IB signature motif; other site 743299005831 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 743299005832 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 743299005833 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 743299005834 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 743299005835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743299005836 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 743299005837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743299005838 DNA binding residues [nucleotide binding] 743299005839 DNA primase; Validated; Region: dnaG; PRK05667 743299005840 CHC2 zinc finger; Region: zf-CHC2; pfam01807 743299005841 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 743299005842 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 743299005843 active site 743299005844 metal binding site [ion binding]; metal-binding site 743299005845 interdomain interaction site; other site 743299005846 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 743299005847 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 743299005848 MutS domain III; Region: MutS_III; pfam05192 743299005849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299005850 Walker A/P-loop; other site 743299005851 ATP binding site [chemical binding]; other site 743299005852 Q-loop/lid; other site 743299005853 ABC transporter signature motif; other site 743299005854 Walker B; other site 743299005855 D-loop; other site 743299005856 H-loop/switch region; other site 743299005857 Smr domain; Region: Smr; pfam01713 743299005858 Yqey-like protein; Region: YqeY; pfam09424 743299005859 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 743299005860 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 743299005861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743299005862 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743299005863 DNA binding residues [nucleotide binding] 743299005864 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 743299005865 active site 743299005866 dimerization interface [polypeptide binding]; other site 743299005867 ribonuclease PH; Reviewed; Region: rph; PRK00173 743299005868 Ribonuclease PH; Region: RNase_PH_bact; cd11362 743299005869 hexamer interface [polypeptide binding]; other site 743299005870 active site 743299005871 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743299005872 ligand binding site [chemical binding]; other site 743299005873 flexible hinge region; other site 743299005874 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 743299005875 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 743299005876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299005877 FeS/SAM binding site; other site 743299005878 HemN C-terminal domain; Region: HemN_C; pfam06969 743299005879 Uncharacterized conserved protein [Function unknown]; Region: COG3461 743299005880 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 743299005881 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743299005882 RNA binding surface [nucleotide binding]; other site 743299005883 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 743299005884 active site 743299005885 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 743299005886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299005887 putative substrate translocation pore; other site 743299005888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299005889 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 743299005890 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 743299005891 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743299005892 Methyltransferase domain; Region: Methyltransf_23; pfam13489 743299005893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299005894 S-adenosylmethionine binding site [chemical binding]; other site 743299005895 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 743299005896 oligomeric interface; other site 743299005897 putative active site [active] 743299005898 homodimer interface [polypeptide binding]; other site 743299005899 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 743299005900 Helix-turn-helix domain; Region: HTH_20; pfam12840 743299005901 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 743299005902 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 743299005903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299005904 ATP binding site [chemical binding]; other site 743299005905 putative Mg++ binding site [ion binding]; other site 743299005906 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 743299005907 Virulence protein [General function prediction only]; Region: COG3943 743299005908 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 743299005909 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 743299005910 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 743299005911 dimerization interface [polypeptide binding]; other site 743299005912 ATP binding site [chemical binding]; other site 743299005913 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 743299005914 dimerization interface [polypeptide binding]; other site 743299005915 ATP binding site [chemical binding]; other site 743299005916 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 743299005917 putative active site [active] 743299005918 catalytic triad [active] 743299005919 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 743299005920 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 743299005921 ATP binding site [chemical binding]; other site 743299005922 active site 743299005923 substrate binding site [chemical binding]; other site 743299005924 adenylosuccinate lyase; Provisional; Region: PRK07492 743299005925 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 743299005926 tetramer interface [polypeptide binding]; other site 743299005927 active site 743299005928 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 743299005929 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 743299005930 dihydrodipicolinate synthase; Region: dapA; TIGR00674 743299005931 dimer interface [polypeptide binding]; other site 743299005932 active site 743299005933 catalytic residue [active] 743299005934 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 743299005935 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 743299005936 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 743299005937 active site 743299005938 metal binding site [ion binding]; metal-binding site 743299005939 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743299005940 thioredoxin 2; Provisional; Region: PRK10996 743299005941 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 743299005942 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743299005943 catalytic residues [active] 743299005944 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 743299005945 GSH binding site [chemical binding]; other site 743299005946 catalytic residues [active] 743299005947 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 743299005948 active site residue [active] 743299005949 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 743299005950 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743299005951 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743299005952 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743299005953 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299005954 Outer membrane efflux protein; Region: OEP; pfam02321 743299005955 Outer membrane efflux protein; Region: OEP; pfam02321 743299005956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743299005957 dimerization interface [polypeptide binding]; other site 743299005958 putative DNA binding site [nucleotide binding]; other site 743299005959 putative Zn2+ binding site [ion binding]; other site 743299005960 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 743299005961 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 743299005962 SCP-2 sterol transfer family; Region: SCP2; pfam02036 743299005963 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 743299005964 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 743299005965 putative ATP binding site [chemical binding]; other site 743299005966 putative substrate interface [chemical binding]; other site 743299005967 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 743299005968 active site 743299005969 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 743299005970 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743299005971 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 743299005972 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743299005973 Membrane fusogenic activity; Region: BMFP; pfam04380 743299005974 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 743299005975 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 743299005976 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 743299005977 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 743299005978 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 743299005979 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 743299005980 tetramer interface [polypeptide binding]; other site 743299005981 heme binding pocket [chemical binding]; other site 743299005982 NADPH binding site [chemical binding]; other site 743299005983 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 743299005984 Sel1-like repeats; Region: SEL1; smart00671 743299005985 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 743299005986 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 743299005987 G1 box; other site 743299005988 putative GEF interaction site [polypeptide binding]; other site 743299005989 GTP/Mg2+ binding site [chemical binding]; other site 743299005990 Switch I region; other site 743299005991 G2 box; other site 743299005992 G3 box; other site 743299005993 Switch II region; other site 743299005994 G4 box; other site 743299005995 G5 box; other site 743299005996 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 743299005997 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 743299005998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743299005999 Coenzyme A binding pocket [chemical binding]; other site 743299006000 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 743299006001 Glycoprotease family; Region: Peptidase_M22; pfam00814 743299006002 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 743299006003 DEAD/DEAH box helicase; Region: DEAD; pfam00270 743299006004 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 743299006005 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 743299006006 NlpC/P60 family; Region: NLPC_P60; pfam00877 743299006007 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299006008 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 743299006009 FeoA domain; Region: FeoA; pfam04023 743299006010 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 743299006011 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 743299006012 G1 box; other site 743299006013 GTP/Mg2+ binding site [chemical binding]; other site 743299006014 Switch I region; other site 743299006015 G2 box; other site 743299006016 G3 box; other site 743299006017 Switch II region; other site 743299006018 G4 box; other site 743299006019 G5 box; other site 743299006020 Nucleoside recognition; Region: Gate; pfam07670 743299006021 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 743299006022 FeoC like transcriptional regulator; Region: FeoC; cl17677 743299006023 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 743299006024 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 743299006025 putative active site; other site 743299006026 catalytic triad [active] 743299006027 putative dimer interface [polypeptide binding]; other site 743299006028 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 743299006029 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 743299006030 catalytic triad [active] 743299006031 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 743299006032 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 743299006033 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 743299006034 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 743299006035 conserved cys residue [active] 743299006036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743299006037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743299006038 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 743299006039 putative dimerization interface [polypeptide binding]; other site 743299006040 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743299006041 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 743299006042 active site 743299006043 catalytic tetrad [active] 743299006044 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 743299006045 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 743299006046 active site 743299006047 Zn binding site [ion binding]; other site 743299006048 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 743299006049 metal ion-dependent adhesion site (MIDAS); other site 743299006050 MoxR-like ATPases [General function prediction only]; Region: COG0714 743299006051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299006052 Walker A motif; other site 743299006053 ATP binding site [chemical binding]; other site 743299006054 Walker B motif; other site 743299006055 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 743299006056 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 743299006057 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 743299006058 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 743299006059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299006060 FeS/SAM binding site; other site 743299006061 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 743299006062 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743299006063 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 743299006064 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 743299006065 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 743299006066 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 743299006067 lipoyl attachment site [posttranslational modification]; other site 743299006068 Predicted peroxiredoxins [General function prediction only]; Region: COG2044 743299006069 glycine cleavage system protein H; Provisional; Region: PRK13380 743299006070 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 743299006071 lipoyl attachment site [posttranslational modification]; other site 743299006072 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 743299006073 Cysteine-rich domain; Region: CCG; pfam02754 743299006074 Cysteine-rich domain; Region: CCG; pfam02754 743299006075 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 743299006076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 743299006077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743299006078 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 743299006079 Cysteine-rich domain; Region: CCG; pfam02754 743299006080 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 743299006081 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 743299006082 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 743299006083 CPxP motif; other site 743299006084 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 743299006085 active site residue [active] 743299006086 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 743299006087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299006088 FeS/SAM binding site; other site 743299006089 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 743299006090 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 743299006091 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 743299006092 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 743299006093 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 743299006094 molybdopterin cofactor binding site; other site 743299006095 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 743299006096 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 743299006097 putative molybdopterin cofactor binding site; other site 743299006098 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 743299006099 trimer interface [polypeptide binding]; other site 743299006100 dimer interface [polypeptide binding]; other site 743299006101 putative active site [active] 743299006102 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 743299006103 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 743299006104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299006105 dimer interface [polypeptide binding]; other site 743299006106 phosphorylation site [posttranslational modification] 743299006107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299006108 ATP binding site [chemical binding]; other site 743299006109 Mg2+ binding site [ion binding]; other site 743299006110 G-X-G motif; other site 743299006111 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743299006112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299006113 active site 743299006114 phosphorylation site [posttranslational modification] 743299006115 intermolecular recognition site; other site 743299006116 dimerization interface [polypeptide binding]; other site 743299006117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299006118 Walker A motif; other site 743299006119 ATP binding site [chemical binding]; other site 743299006120 Walker B motif; other site 743299006121 arginine finger; other site 743299006122 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743299006123 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 743299006124 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 743299006125 Domain of unknown function DUF302; Region: DUF302; cl01364 743299006126 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 743299006127 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 743299006128 active site 743299006129 metal binding site [ion binding]; metal-binding site 743299006130 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 743299006131 rod shape-determining protein MreB; Provisional; Region: PRK13927 743299006132 MreB and similar proteins; Region: MreB_like; cd10225 743299006133 nucleotide binding site [chemical binding]; other site 743299006134 Mg binding site [ion binding]; other site 743299006135 putative protofilament interaction site [polypeptide binding]; other site 743299006136 RodZ interaction site [polypeptide binding]; other site 743299006137 rod shape-determining protein MreC; Provisional; Region: PRK13922 743299006138 rod shape-determining protein MreC; Region: MreC; pfam04085 743299006139 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 743299006140 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 743299006141 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 743299006142 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 743299006143 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 743299006144 Protein of unknown function (DUF493); Region: DUF493; pfam04359 743299006145 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 743299006146 lipoyl synthase; Provisional; Region: PRK05481 743299006147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299006148 FeS/SAM binding site; other site 743299006149 Uncharacterized conserved protein [Function unknown]; Region: COG1434 743299006150 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 743299006151 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 743299006152 putative active site [active] 743299006153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 743299006154 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 743299006155 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 743299006156 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 743299006157 G1 box; other site 743299006158 GTP/Mg2+ binding site [chemical binding]; other site 743299006159 G2 box; other site 743299006160 Switch I region; other site 743299006161 G3 box; other site 743299006162 Switch II region; other site 743299006163 G4 box; other site 743299006164 G5 box; other site 743299006165 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 743299006166 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 743299006167 dimer interface [polypeptide binding]; other site 743299006168 motif 1; other site 743299006169 active site 743299006170 motif 2; other site 743299006171 motif 3; other site 743299006172 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 743299006173 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 743299006174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299006175 active site 743299006176 motif I; other site 743299006177 motif II; other site 743299006178 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 743299006179 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743299006180 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743299006181 putative acyl-acceptor binding pocket; other site 743299006182 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 743299006183 ATP-grasp domain; Region: ATP-grasp_4; cl17255 743299006184 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 743299006185 Cysteine-rich domain; Region: CCG; pfam02754 743299006186 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 743299006187 aromatic arch; other site 743299006188 DCoH dimer interaction site [polypeptide binding]; other site 743299006189 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 743299006190 DCoH tetramer interaction site [polypeptide binding]; other site 743299006191 substrate binding site [chemical binding]; other site 743299006192 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 743299006193 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 743299006194 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 743299006195 substrate binding site [chemical binding]; other site 743299006196 amidase catalytic site [active] 743299006197 Zn binding residues [ion binding]; other site 743299006198 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743299006199 catalytic residues [active] 743299006200 2-isopropylmalate synthase; Validated; Region: PRK00915 743299006201 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 743299006202 active site 743299006203 catalytic residues [active] 743299006204 metal binding site [ion binding]; metal-binding site 743299006205 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 743299006206 Uncharacterized conserved protein [Function unknown]; Region: COG2128 743299006207 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 743299006208 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 743299006209 DNA binding residues [nucleotide binding] 743299006210 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743299006211 IHF - DNA interface [nucleotide binding]; other site 743299006212 IHF dimer interface [polypeptide binding]; other site 743299006213 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 743299006214 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 743299006215 putative tRNA-binding site [nucleotide binding]; other site 743299006216 B3/4 domain; Region: B3_4; pfam03483 743299006217 tRNA synthetase B5 domain; Region: B5; smart00874 743299006218 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 743299006219 dimer interface [polypeptide binding]; other site 743299006220 motif 1; other site 743299006221 motif 3; other site 743299006222 motif 2; other site 743299006223 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 743299006224 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 743299006225 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 743299006226 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 743299006227 dimer interface [polypeptide binding]; other site 743299006228 motif 1; other site 743299006229 active site 743299006230 motif 2; other site 743299006231 motif 3; other site 743299006232 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 743299006233 23S rRNA binding site [nucleotide binding]; other site 743299006234 L21 binding site [polypeptide binding]; other site 743299006235 L13 binding site [polypeptide binding]; other site 743299006236 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 743299006237 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 743299006238 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 743299006239 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 743299006240 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 743299006241 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 743299006242 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 743299006243 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 743299006244 active site 743299006245 dimer interface [polypeptide binding]; other site 743299006246 motif 1; other site 743299006247 motif 2; other site 743299006248 motif 3; other site 743299006249 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 743299006250 anticodon binding site; other site 743299006251 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 743299006252 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 743299006253 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743299006254 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 743299006255 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743299006256 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 743299006257 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 743299006258 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743299006259 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 743299006260 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 743299006261 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 743299006262 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 743299006263 4Fe-4S binding domain; Region: Fer4; pfam00037 743299006264 4Fe-4S binding domain; Region: Fer4; pfam00037 743299006265 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 743299006266 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 743299006267 NADH dehydrogenase subunit G; Validated; Region: PRK09129 743299006268 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743299006269 catalytic loop [active] 743299006270 iron binding site [ion binding]; other site 743299006271 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 743299006272 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 743299006273 molybdopterin cofactor binding site; other site 743299006274 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 743299006275 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 743299006276 SLBB domain; Region: SLBB; pfam10531 743299006277 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 743299006278 NADH dehydrogenase subunit E; Validated; Region: PRK07539 743299006279 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 743299006280 putative dimer interface [polypeptide binding]; other site 743299006281 [2Fe-2S] cluster binding site [ion binding]; other site 743299006282 NADH dehydrogenase subunit D; Validated; Region: PRK06075 743299006283 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 743299006284 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 743299006285 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 743299006286 NADH dehydrogenase subunit B; Validated; Region: PRK06411 743299006287 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 743299006288 Preprotein translocase SecG subunit; Region: SecG; pfam03840 743299006289 triosephosphate isomerase; Provisional; Region: PRK14567 743299006290 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 743299006291 substrate binding site [chemical binding]; other site 743299006292 dimer interface [polypeptide binding]; other site 743299006293 catalytic triad [active] 743299006294 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 743299006295 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 743299006296 active site 743299006297 substrate binding site [chemical binding]; other site 743299006298 metal binding site [ion binding]; metal-binding site 743299006299 dihydropteroate synthase; Region: DHPS; TIGR01496 743299006300 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 743299006301 substrate binding pocket [chemical binding]; other site 743299006302 dimer interface [polypeptide binding]; other site 743299006303 inhibitor binding site; inhibition site 743299006304 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 743299006305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299006306 Walker A motif; other site 743299006307 ATP binding site [chemical binding]; other site 743299006308 Walker B motif; other site 743299006309 arginine finger; other site 743299006310 Peptidase family M41; Region: Peptidase_M41; pfam01434 743299006311 protease TldD; Provisional; Region: tldD; PRK10735 743299006312 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 743299006313 ATP cone domain; Region: ATP-cone; pfam03477 743299006314 ATP cone domain; Region: ATP-cone; pfam03477 743299006315 Class I ribonucleotide reductase; Region: RNR_I; cd01679 743299006316 active site 743299006317 dimer interface [polypeptide binding]; other site 743299006318 catalytic residues [active] 743299006319 effector binding site; other site 743299006320 R2 peptide binding site; other site 743299006321 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 743299006322 dimer interface [polypeptide binding]; other site 743299006323 putative radical transfer pathway; other site 743299006324 diiron center [ion binding]; other site 743299006325 tyrosyl radical; other site 743299006326 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 743299006327 active site 743299006328 Archaeal ATPase; Region: Arch_ATPase; pfam01637 743299006329 putative transposase OrfB; Reviewed; Region: PHA02517 743299006330 Integrase core domain; Region: rve; pfam00665 743299006331 AAA domain; Region: AAA_22; pfam13401 743299006332 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299006333 Walker A motif; other site 743299006334 ATP binding site [chemical binding]; other site 743299006335 Walker B motif; other site 743299006336 TniQ; Region: TniQ; pfam06527 743299006337 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 743299006338 DNA binding residues [nucleotide binding] 743299006339 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 743299006340 metal binding triad [ion binding]; metal-binding site 743299006341 Uncharacterized conserved protein [Function unknown]; Region: COG2361 743299006342 EamA-like transporter family; Region: EamA; pfam00892 743299006343 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 743299006344 EamA-like transporter family; Region: EamA; pfam00892 743299006345 intersubunit interface [polypeptide binding]; other site 743299006346 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 743299006347 active site 743299006348 Zn2+ binding site [ion binding]; other site 743299006349 Predicted transcriptional regulators [Transcription]; Region: COG1695 743299006350 Transcriptional regulator PadR-like family; Region: PadR; cl17335 743299006351 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 743299006352 active site residue [active] 743299006353 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 743299006354 Subunit I/III interface [polypeptide binding]; other site 743299006355 cytochrome o ubiquinol oxidase, subunit I; Region: CyoB; TIGR02843 743299006356 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 743299006357 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 743299006358 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 743299006359 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 743299006360 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 743299006361 Sulphur oxygenase reductase; Region: SOR; pfam07682 743299006362 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 743299006363 PQQ-like domain; Region: PQQ_2; pfam13360 743299006364 Trp docking motif [polypeptide binding]; other site 743299006365 active site 743299006366 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 743299006367 TrkA-N domain; Region: TrkA_N; pfam02254 743299006368 Domain of unknown function (DUF1817); Region: DUF1817; cl02292 743299006369 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743299006370 IHF dimer interface [polypeptide binding]; other site 743299006371 IHF - DNA interface [nucleotide binding]; other site 743299006372 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 743299006373 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 743299006374 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 743299006375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299006376 catalytic residue [active] 743299006377 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 743299006378 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 743299006379 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 743299006380 putative active site [active] 743299006381 catalytic site [active] 743299006382 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 743299006383 putative active site [active] 743299006384 catalytic site [active] 743299006385 Transposase domain (DUF772); Region: DUF772; pfam05598 743299006386 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 743299006387 DDE superfamily endonuclease; Region: DDE_4; cl17710 743299006388 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 743299006389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 743299006390 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 743299006391 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 743299006392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 743299006393 Transposase; Region: DEDD_Tnp_IS110; pfam01548 743299006394 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 743299006395 Predicted membrane protein [Function unknown]; Region: COG2259 743299006396 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 743299006397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743299006398 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743299006399 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 743299006400 Flavodoxin; Region: Flavodoxin_1; pfam00258 743299006401 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 743299006402 FAD binding pocket [chemical binding]; other site 743299006403 FAD binding motif [chemical binding]; other site 743299006404 catalytic residues [active] 743299006405 NAD binding pocket [chemical binding]; other site 743299006406 phosphate binding motif [ion binding]; other site 743299006407 beta-alpha-beta structure motif; other site 743299006408 sulfite reductase subunit beta; Provisional; Region: PRK13504 743299006409 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743299006410 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743299006411 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 743299006412 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 743299006413 Active Sites [active] 743299006414 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 743299006415 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 743299006416 Active Sites [active] 743299006417 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 743299006418 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 743299006419 CysD dimerization site [polypeptide binding]; other site 743299006420 G1 box; other site 743299006421 putative GEF interaction site [polypeptide binding]; other site 743299006422 GTP/Mg2+ binding site [chemical binding]; other site 743299006423 Switch I region; other site 743299006424 G2 box; other site 743299006425 G3 box; other site 743299006426 Switch II region; other site 743299006427 G4 box; other site 743299006428 G5 box; other site 743299006429 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 743299006430 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 743299006431 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 743299006432 active site 743299006433 SAM binding site [chemical binding]; other site 743299006434 homodimer interface [polypeptide binding]; other site 743299006435 OsmC-like protein; Region: OsmC; pfam02566 743299006436 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 743299006437 CPxP motif; other site 743299006438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 743299006439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743299006440 aspartate kinase; Reviewed; Region: PRK06635 743299006441 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 743299006442 putative nucleotide binding site [chemical binding]; other site 743299006443 putative catalytic residues [active] 743299006444 putative Mg ion binding site [ion binding]; other site 743299006445 putative aspartate binding site [chemical binding]; other site 743299006446 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 743299006447 putative allosteric regulatory site; other site 743299006448 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 743299006449 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743299006450 acetylornithine aminotransferase; Provisional; Region: PRK02627 743299006451 inhibitor-cofactor binding pocket; inhibition site 743299006452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299006453 catalytic residue [active] 743299006454 ornithine carbamoyltransferase; Provisional; Region: PRK00779 743299006455 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 743299006456 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 743299006457 argininosuccinate synthase; Provisional; Region: PRK13820 743299006458 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 743299006459 ANP binding site [chemical binding]; other site 743299006460 Substrate Binding Site II [chemical binding]; other site 743299006461 Substrate Binding Site I [chemical binding]; other site 743299006462 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 743299006463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743299006464 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 743299006465 dimer interface [polypeptide binding]; other site 743299006466 active site 743299006467 metal binding site [ion binding]; metal-binding site 743299006468 glutathione binding site [chemical binding]; other site 743299006469 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 743299006470 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 743299006471 active site 743299006472 catalytic site [active] 743299006473 substrate binding site [chemical binding]; other site 743299006474 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 743299006475 RNA/DNA hybrid binding site [nucleotide binding]; other site 743299006476 active site 743299006477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743299006478 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 743299006479 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 743299006480 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 743299006481 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 743299006482 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 743299006483 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 743299006484 RNase E interface [polypeptide binding]; other site 743299006485 trimer interface [polypeptide binding]; other site 743299006486 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 743299006487 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 743299006488 RNase E interface [polypeptide binding]; other site 743299006489 trimer interface [polypeptide binding]; other site 743299006490 active site 743299006491 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 743299006492 putative nucleic acid binding region [nucleotide binding]; other site 743299006493 G-X-X-G motif; other site 743299006494 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 743299006495 RNA binding site [nucleotide binding]; other site 743299006496 domain interface; other site 743299006497 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 743299006498 16S/18S rRNA binding site [nucleotide binding]; other site 743299006499 S13e-L30e interaction site [polypeptide binding]; other site 743299006500 25S rRNA binding site [nucleotide binding]; other site 743299006501 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 743299006502 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 743299006503 RNA binding site [nucleotide binding]; other site 743299006504 active site 743299006505 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 743299006506 Ribosome-binding factor A; Region: RBFA; pfam02033 743299006507 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 743299006508 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 743299006509 translation initiation factor IF-2; Region: IF-2; TIGR00487 743299006510 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 743299006511 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 743299006512 G1 box; other site 743299006513 putative GEF interaction site [polypeptide binding]; other site 743299006514 GTP/Mg2+ binding site [chemical binding]; other site 743299006515 Switch I region; other site 743299006516 G2 box; other site 743299006517 G3 box; other site 743299006518 Switch II region; other site 743299006519 G4 box; other site 743299006520 G5 box; other site 743299006521 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 743299006522 Translation-initiation factor 2; Region: IF-2; pfam11987 743299006523 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 743299006524 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 743299006525 NusA N-terminal domain; Region: NusA_N; pfam08529 743299006526 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 743299006527 RNA binding site [nucleotide binding]; other site 743299006528 homodimer interface [polypeptide binding]; other site 743299006529 NusA-like KH domain; Region: KH_5; pfam13184 743299006530 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 743299006531 G-X-X-G motif; other site 743299006532 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 743299006533 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 743299006534 ribosome maturation protein RimP; Reviewed; Region: PRK00092 743299006535 Sm and related proteins; Region: Sm_like; cl00259 743299006536 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 743299006537 putative oligomer interface [polypeptide binding]; other site 743299006538 putative RNA binding site [nucleotide binding]; other site 743299006539 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743299006540 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 743299006541 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 743299006542 seryl-tRNA synthetase; Provisional; Region: PRK05431 743299006543 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 743299006544 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 743299006545 dimer interface [polypeptide binding]; other site 743299006546 active site 743299006547 motif 1; other site 743299006548 motif 2; other site 743299006549 motif 3; other site 743299006550 recombination factor protein RarA; Reviewed; Region: PRK13342 743299006551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299006552 Walker A motif; other site 743299006553 ATP binding site [chemical binding]; other site 743299006554 Walker B motif; other site 743299006555 arginine finger; other site 743299006556 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 743299006557 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 743299006558 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 743299006559 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 743299006560 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 743299006561 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 743299006562 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 743299006563 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 743299006564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743299006565 Smr domain; Region: Smr; pfam01713 743299006566 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 743299006567 DNA binding residues [nucleotide binding] 743299006568 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 743299006569 dimer interface [polypeptide binding]; other site 743299006570 metal binding site [ion binding]; metal-binding site 743299006571 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 743299006572 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 743299006573 Permutation of conserved domain; other site 743299006574 active site 743299006575 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 743299006576 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 743299006577 homotrimer interaction site [polypeptide binding]; other site 743299006578 zinc binding site [ion binding]; other site 743299006579 CDP-binding sites; other site 743299006580 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 743299006581 substrate binding site; other site 743299006582 dimer interface; other site 743299006583 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 743299006584 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 743299006585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743299006586 ATP binding site [chemical binding]; other site 743299006587 putative Mg++ binding site [ion binding]; other site 743299006588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743299006589 nucleotide binding region [chemical binding]; other site 743299006590 ATP-binding site [chemical binding]; other site 743299006591 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 743299006592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 743299006593 Transposase; Region: DDE_Tnp_ISL3; pfam01610 743299006594 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 743299006595 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 743299006596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743299006597 motif II; other site 743299006598 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 743299006599 catalytic triad [active] 743299006600 dimer interface [polypeptide binding]; other site 743299006601 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299006602 glutathione reductase; Validated; Region: PRK06116 743299006603 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 743299006604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743299006605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743299006606 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743299006607 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 743299006608 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743299006609 active site 743299006610 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 743299006611 UDP-glycosyltransferase; Region: PLN02534 743299006612 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 743299006613 active site 743299006614 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 743299006615 hypothetical protein; Reviewed; Region: PRK00024 743299006616 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 743299006617 MPN+ (JAMM) motif; other site 743299006618 Zinc-binding site [ion binding]; other site 743299006619 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 743299006620 Flavoprotein; Region: Flavoprotein; pfam02441 743299006621 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 743299006622 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 743299006623 trimer interface [polypeptide binding]; other site 743299006624 active site 743299006625 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 743299006626 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 743299006627 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 743299006628 alphaNTD homodimer interface [polypeptide binding]; other site 743299006629 alphaNTD - beta interaction site [polypeptide binding]; other site 743299006630 alphaNTD - beta' interaction site [polypeptide binding]; other site 743299006631 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 743299006632 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 743299006633 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 743299006634 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743299006635 RNA binding surface [nucleotide binding]; other site 743299006636 30S ribosomal protein S11; Validated; Region: PRK05309 743299006637 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 743299006638 30S ribosomal protein S13; Region: bact_S13; TIGR03631 743299006639 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 743299006640 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 743299006641 rRNA binding site [nucleotide binding]; other site 743299006642 predicted 30S ribosome binding site; other site 743299006643 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 743299006644 adenylate kinase; Reviewed; Region: adk; PRK00279 743299006645 AMP-binding site [chemical binding]; other site 743299006646 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 743299006647 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 743299006648 SecY translocase; Region: SecY; pfam00344 743299006649 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 743299006650 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 743299006651 23S rRNA binding site [nucleotide binding]; other site 743299006652 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 743299006653 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 743299006654 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 743299006655 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 743299006656 5S rRNA interface [nucleotide binding]; other site 743299006657 23S rRNA interface [nucleotide binding]; other site 743299006658 L5 interface [polypeptide binding]; other site 743299006659 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 743299006660 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 743299006661 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 743299006662 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 743299006663 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 743299006664 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 743299006665 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 743299006666 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 743299006667 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 743299006668 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 743299006669 RNA binding site [nucleotide binding]; other site 743299006670 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 743299006671 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 743299006672 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 743299006673 putative translocon interaction site; other site 743299006674 23S rRNA interface [nucleotide binding]; other site 743299006675 signal recognition particle (SRP54) interaction site; other site 743299006676 L23 interface [polypeptide binding]; other site 743299006677 trigger factor interaction site; other site 743299006678 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 743299006679 23S rRNA interface [nucleotide binding]; other site 743299006680 5S rRNA interface [nucleotide binding]; other site 743299006681 putative antibiotic binding site [chemical binding]; other site 743299006682 L25 interface [polypeptide binding]; other site 743299006683 L27 interface [polypeptide binding]; other site 743299006684 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 743299006685 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 743299006686 G-X-X-G motif; other site 743299006687 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 743299006688 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 743299006689 protein-rRNA interface [nucleotide binding]; other site 743299006690 putative translocon binding site; other site 743299006691 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 743299006692 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 743299006693 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 743299006694 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 743299006695 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 743299006696 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 743299006697 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 743299006698 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 743299006699 elongation factor Tu; Reviewed; Region: PRK00049 743299006700 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 743299006701 G1 box; other site 743299006702 GEF interaction site [polypeptide binding]; other site 743299006703 GTP/Mg2+ binding site [chemical binding]; other site 743299006704 Switch I region; other site 743299006705 G2 box; other site 743299006706 G3 box; other site 743299006707 Switch II region; other site 743299006708 G4 box; other site 743299006709 G5 box; other site 743299006710 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 743299006711 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 743299006712 Antibiotic Binding Site [chemical binding]; other site 743299006713 elongation factor G; Reviewed; Region: PRK00007 743299006714 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 743299006715 G1 box; other site 743299006716 putative GEF interaction site [polypeptide binding]; other site 743299006717 GTP/Mg2+ binding site [chemical binding]; other site 743299006718 Switch I region; other site 743299006719 G2 box; other site 743299006720 G3 box; other site 743299006721 Switch II region; other site 743299006722 G4 box; other site 743299006723 G5 box; other site 743299006724 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 743299006725 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 743299006726 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 743299006727 30S ribosomal protein S7; Validated; Region: PRK05302 743299006728 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 743299006729 S17 interaction site [polypeptide binding]; other site 743299006730 S8 interaction site; other site 743299006731 16S rRNA interaction site [nucleotide binding]; other site 743299006732 streptomycin interaction site [chemical binding]; other site 743299006733 23S rRNA interaction site [nucleotide binding]; other site 743299006734 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 743299006735 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 743299006736 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 743299006737 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 743299006738 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 743299006739 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 743299006740 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 743299006741 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 743299006742 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 743299006743 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 743299006744 DNA binding site [nucleotide binding] 743299006745 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 743299006746 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 743299006747 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 743299006748 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 743299006749 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 743299006750 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 743299006751 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 743299006752 RPB3 interaction site [polypeptide binding]; other site 743299006753 RPB1 interaction site [polypeptide binding]; other site 743299006754 RPB11 interaction site [polypeptide binding]; other site 743299006755 RPB10 interaction site [polypeptide binding]; other site 743299006756 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 743299006757 peripheral dimer interface [polypeptide binding]; other site 743299006758 core dimer interface [polypeptide binding]; other site 743299006759 L10 interface [polypeptide binding]; other site 743299006760 L11 interface [polypeptide binding]; other site 743299006761 putative EF-Tu interaction site [polypeptide binding]; other site 743299006762 putative EF-G interaction site [polypeptide binding]; other site 743299006763 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 743299006764 23S rRNA interface [nucleotide binding]; other site 743299006765 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 743299006766 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 743299006767 mRNA/rRNA interface [nucleotide binding]; other site 743299006768 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 743299006769 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 743299006770 23S rRNA interface [nucleotide binding]; other site 743299006771 L7/L12 interface [polypeptide binding]; other site 743299006772 putative thiostrepton binding site; other site 743299006773 L25 interface [polypeptide binding]; other site 743299006774 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 743299006775 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 743299006776 putative homodimer interface [polypeptide binding]; other site 743299006777 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 743299006778 heterodimer interface [polypeptide binding]; other site 743299006779 homodimer interface [polypeptide binding]; other site 743299006780 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 743299006781 elongation factor Tu; Reviewed; Region: PRK00049 743299006782 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 743299006783 G1 box; other site 743299006784 GEF interaction site [polypeptide binding]; other site 743299006785 GTP/Mg2+ binding site [chemical binding]; other site 743299006786 Switch I region; other site 743299006787 G2 box; other site 743299006788 G3 box; other site 743299006789 Switch II region; other site 743299006790 G4 box; other site 743299006791 G5 box; other site 743299006792 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 743299006793 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 743299006794 Antibiotic Binding Site [chemical binding]; other site 743299006795 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743299006796 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743299006797 ligand binding site [chemical binding]; other site 743299006798 ABC1 family; Region: ABC1; cl17513 743299006799 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 743299006800 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 743299006801 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 743299006802 Sel1-like repeats; Region: SEL1; smart00671 743299006803 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 743299006804 transcription antitermination factor NusB; Region: nusB; TIGR01951 743299006805 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 743299006806 homopentamer interface [polypeptide binding]; other site 743299006807 active site 743299006808 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 743299006809 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 743299006810 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 743299006811 dimerization interface [polypeptide binding]; other site 743299006812 active site 743299006813 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 743299006814 Lumazine binding domain; Region: Lum_binding; pfam00677 743299006815 Lumazine binding domain; Region: Lum_binding; pfam00677 743299006816 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 743299006817 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 743299006818 catalytic motif [active] 743299006819 Zn binding site [ion binding]; other site 743299006820 RibD C-terminal domain; Region: RibD_C; cl17279 743299006821 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 743299006822 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 743299006823 ATP cone domain; Region: ATP-cone; pfam03477 743299006824 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 743299006825 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 743299006826 dimer interface [polypeptide binding]; other site 743299006827 active site 743299006828 glycine-pyridoxal phosphate binding site [chemical binding]; other site 743299006829 folate binding site [chemical binding]; other site 743299006830 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 743299006831 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 743299006832 Methyltransferase domain; Region: Methyltransf_31; pfam13847 743299006833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299006834 S-adenosylmethionine binding site [chemical binding]; other site 743299006835 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743299006836 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 743299006837 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 743299006838 N-terminal domain interface [polypeptide binding]; other site 743299006839 dimer interface [polypeptide binding]; other site 743299006840 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 743299006841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299006842 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 743299006843 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 743299006844 THF binding site; other site 743299006845 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 743299006846 substrate binding site [chemical binding]; other site 743299006847 THF binding site; other site 743299006848 zinc-binding site [ion binding]; other site 743299006849 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 743299006850 active site clefts [active] 743299006851 zinc binding site [ion binding]; other site 743299006852 dimer interface [polypeptide binding]; other site 743299006853 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 743299006854 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 743299006855 Sulfate transporter family; Region: Sulfate_transp; pfam00916 743299006856 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 743299006857 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 743299006858 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 743299006859 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 743299006860 GTP1/OBG; Region: GTP1_OBG; pfam01018 743299006861 Obg GTPase; Region: Obg; cd01898 743299006862 G1 box; other site 743299006863 GTP/Mg2+ binding site [chemical binding]; other site 743299006864 Switch I region; other site 743299006865 G2 box; other site 743299006866 G3 box; other site 743299006867 Switch II region; other site 743299006868 G4 box; other site 743299006869 G5 box; other site 743299006870 gamma-glutamyl kinase; Provisional; Region: PRK05429 743299006871 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 743299006872 nucleotide binding site [chemical binding]; other site 743299006873 homotetrameric interface [polypeptide binding]; other site 743299006874 putative phosphate binding site [ion binding]; other site 743299006875 putative allosteric binding site; other site 743299006876 PUA domain; Region: PUA; pfam01472 743299006877 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 743299006878 metal binding site 2 [ion binding]; metal-binding site 743299006879 putative DNA binding helix; other site 743299006880 metal binding site 1 [ion binding]; metal-binding site 743299006881 dimer interface [polypeptide binding]; other site 743299006882 structural Zn2+ binding site [ion binding]; other site 743299006883 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 743299006884 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 743299006885 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 743299006886 putative coenzyme Q binding site [chemical binding]; other site 743299006887 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 743299006888 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 743299006889 putative active site [active] 743299006890 catalytic site [active] 743299006891 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 743299006892 putative active site [active] 743299006893 catalytic site [active] 743299006894 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 743299006895 SmpB-tmRNA interface; other site 743299006896 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 743299006897 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 743299006898 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 743299006899 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 743299006900 ATP-grasp domain; Region: ATP-grasp; pfam02222 743299006901 AIR carboxylase; Region: AIRC; pfam00731 743299006902 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 743299006903 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 743299006904 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 743299006905 DXD motif; other site 743299006906 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 743299006907 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299006908 Walker A motif; other site 743299006909 ATP binding site [chemical binding]; other site 743299006910 Walker B motif; other site 743299006911 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 743299006912 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 743299006913 Walker A motif; other site 743299006914 ATP binding site [chemical binding]; other site 743299006915 Walker B motif; other site 743299006916 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 743299006917 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743299006918 catalytic residue [active] 743299006919 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 743299006920 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 743299006921 YGGT family; Region: YGGT; pfam02325 743299006922 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 743299006923 biotin synthase; Region: bioB; TIGR00433 743299006924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299006925 FeS/SAM binding site; other site 743299006926 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 743299006927 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 743299006928 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 743299006929 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743299006930 HlyD family secretion protein; Region: HlyD_3; pfam13437 743299006931 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 743299006932 feedback inhibition sensing region; other site 743299006933 homohexameric interface [polypeptide binding]; other site 743299006934 nucleotide binding site [chemical binding]; other site 743299006935 N-acetyl-L-glutamate binding site [chemical binding]; other site 743299006936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743299006937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743299006938 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 743299006939 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 743299006940 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743299006941 catalytic loop [active] 743299006942 iron binding site [ion binding]; other site 743299006943 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 743299006944 FAD binding pocket [chemical binding]; other site 743299006945 FAD binding motif [chemical binding]; other site 743299006946 phosphate binding motif [ion binding]; other site 743299006947 beta-alpha-beta structure motif; other site 743299006948 NAD binding pocket [chemical binding]; other site 743299006949 ribonuclease T; Provisional; Region: PRK05168 743299006950 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 743299006951 active site 743299006952 catalytic site [active] 743299006953 substrate binding site [chemical binding]; other site 743299006954 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 743299006955 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 743299006956 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 743299006957 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 743299006958 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 743299006959 Peptidase family M48; Region: Peptidase_M48; cl12018 743299006960 AAA domain; Region: AAA_26; pfam13500 743299006961 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 743299006962 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 743299006963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299006964 S-adenosylmethionine binding site [chemical binding]; other site 743299006965 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 743299006966 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 743299006967 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 743299006968 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743299006969 catalytic residue [active] 743299006970 comF family protein; Region: comF; TIGR00201 743299006971 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743299006972 active site 743299006973 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 743299006974 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 743299006975 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 743299006976 Methyltransferase domain; Region: Methyltransf_31; pfam13847 743299006977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299006978 S-adenosylmethionine binding site [chemical binding]; other site 743299006979 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 743299006980 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743299006981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299006982 homodimer interface [polypeptide binding]; other site 743299006983 catalytic residue [active] 743299006984 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 743299006985 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 743299006986 putative acyl-acceptor binding pocket; other site 743299006987 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 743299006988 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 743299006989 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743299006990 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 743299006991 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 743299006992 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 743299006993 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743299006994 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 743299006995 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 743299006996 putative metal binding site; other site 743299006997 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 743299006998 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743299006999 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743299007000 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 743299007001 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743299007002 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 743299007003 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 743299007004 putative active site [active] 743299007005 putative metal binding site [ion binding]; other site 743299007006 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 743299007007 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 743299007008 Ligand binding site; other site 743299007009 Putative Catalytic site; other site 743299007010 DXD motif; other site 743299007011 hypothetical protein; Provisional; Region: PRK08999 743299007012 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 743299007013 active site 743299007014 8-oxo-dGMP binding site [chemical binding]; other site 743299007015 nudix motif; other site 743299007016 metal binding site [ion binding]; metal-binding site 743299007017 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 743299007018 thiamine phosphate binding site [chemical binding]; other site 743299007019 active site 743299007020 pyrophosphate binding site [ion binding]; other site 743299007021 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 743299007022 heterotetramer interface [polypeptide binding]; other site 743299007023 active site pocket [active] 743299007024 cleavage site 743299007025 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 743299007026 DEAD/DEAH box helicase; Region: DEAD; pfam00270 743299007027 ATP binding site [chemical binding]; other site 743299007028 putative Mg++ binding site [ion binding]; other site 743299007029 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 743299007030 SEC-C motif; Region: SEC-C; pfam02810 743299007031 Protein of unknown function (DUF721); Region: DUF721; pfam05258 743299007032 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 743299007033 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 743299007034 stringent starvation protein A; Provisional; Region: sspA; PRK09481 743299007035 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 743299007036 C-terminal domain interface [polypeptide binding]; other site 743299007037 putative GSH binding site (G-site) [chemical binding]; other site 743299007038 dimer interface [polypeptide binding]; other site 743299007039 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 743299007040 N-terminal domain interface [polypeptide binding]; other site 743299007041 dimer interface [polypeptide binding]; other site 743299007042 substrate binding pocket (H-site) [chemical binding]; other site 743299007043 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 743299007044 AMP-binding enzyme; Region: AMP-binding; pfam00501 743299007045 acyl-activating enzyme (AAE) consensus motif; other site 743299007046 putative AMP binding site [chemical binding]; other site 743299007047 putative active site [active] 743299007048 putative CoA binding site [chemical binding]; other site 743299007049 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 743299007050 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 743299007051 metal binding triad [ion binding]; metal-binding site 743299007052 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 743299007053 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743299007054 Zn2+ binding site [ion binding]; other site 743299007055 Mg2+ binding site [ion binding]; other site 743299007056 cell division protein MraZ; Reviewed; Region: PRK00326 743299007057 MraZ protein; Region: MraZ; pfam02381 743299007058 MraZ protein; Region: MraZ; pfam02381 743299007059 MraW methylase family; Region: Methyltransf_5; cl17771 743299007060 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 743299007061 Cell division protein FtsL; Region: FtsL; pfam04999 743299007062 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 743299007063 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 743299007064 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 743299007065 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 743299007066 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743299007067 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743299007068 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 743299007069 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743299007070 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743299007071 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743299007072 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 743299007073 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 743299007074 Mg++ binding site [ion binding]; other site 743299007075 putative catalytic motif [active] 743299007076 putative substrate binding site [chemical binding]; other site 743299007077 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 743299007078 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 743299007079 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743299007080 cell division protein FtsW; Region: ftsW; TIGR02614 743299007081 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 743299007082 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 743299007083 active site 743299007084 homodimer interface [polypeptide binding]; other site 743299007085 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 743299007086 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743299007087 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743299007088 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743299007089 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 743299007090 FAD binding domain; Region: FAD_binding_4; pfam01565 743299007091 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 743299007092 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 743299007093 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 743299007094 ATP-grasp domain; Region: ATP-grasp_4; cl17255 743299007095 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 743299007096 Cell division protein FtsQ; Region: FtsQ; pfam03799 743299007097 cell division protein FtsA; Region: ftsA; TIGR01174 743299007098 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 743299007099 nucleotide binding site [chemical binding]; other site 743299007100 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 743299007101 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 743299007102 Cell division protein FtsA; Region: FtsA; pfam14450 743299007103 cell division protein FtsZ; Validated; Region: PRK09330 743299007104 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 743299007105 nucleotide binding site [chemical binding]; other site 743299007106 SulA interaction site; other site 743299007107 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 743299007108 dinuclear metal binding motif [ion binding]; other site 743299007109 Dehydroquinase class II; Region: DHquinase_II; pfam01220 743299007110 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 743299007111 trimer interface [polypeptide binding]; other site 743299007112 active site 743299007113 dimer interface [polypeptide binding]; other site 743299007114 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 743299007115 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743299007116 carboxyltransferase (CT) interaction site; other site 743299007117 biotinylation site [posttranslational modification]; other site 743299007118 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 743299007119 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743299007120 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 743299007121 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 743299007122 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 743299007123 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 743299007124 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 743299007125 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 743299007126 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 743299007127 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743299007128 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743299007129 catalytic residue [active] 743299007130 Stringent starvation protein B; Region: SspB; cl01120 743299007131 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 743299007132 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 743299007133 NodB motif; other site 743299007134 active site 743299007135 catalytic site [active] 743299007136 metal binding site [ion binding]; metal-binding site 743299007137 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 743299007138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743299007139 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 743299007140 homotrimer interaction site [polypeptide binding]; other site 743299007141 putative active site [active] 743299007142 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 743299007143 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743299007144 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743299007145 putative acyl-acceptor binding pocket; other site 743299007146 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 743299007147 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 743299007148 Ligand binding site; other site 743299007149 Putative Catalytic site; other site 743299007150 DXD motif; other site 743299007151 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 743299007152 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 743299007153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299007154 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743299007155 NAD(P) binding site [chemical binding]; other site 743299007156 active site 743299007157 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743299007158 active site 2 [active] 743299007159 active site 1 [active] 743299007160 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 743299007161 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 743299007162 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 743299007163 active site 743299007164 Phosphopantetheine attachment site; Region: PP-binding; cl09936 743299007165 Predicted exporter [General function prediction only]; Region: COG4258 743299007166 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 743299007167 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 743299007168 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 743299007169 putative acyl-acceptor binding pocket; other site 743299007170 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 743299007171 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 743299007172 acyl-activating enzyme (AAE) consensus motif; other site 743299007173 AMP binding site [chemical binding]; other site 743299007174 active site 743299007175 CoA binding site [chemical binding]; other site 743299007176 Predicted membrane protein [Function unknown]; Region: COG4648 743299007177 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 743299007178 AMP binding site [chemical binding]; other site 743299007179 metal binding site [ion binding]; metal-binding site 743299007180 active site 743299007181 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 743299007182 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 743299007183 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 743299007184 CoA-binding site [chemical binding]; other site 743299007185 ATP-binding [chemical binding]; other site 743299007186 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 743299007187 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 743299007188 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 743299007189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299007190 Response regulator receiver domain; Region: Response_reg; pfam00072 743299007191 active site 743299007192 phosphorylation site [posttranslational modification] 743299007193 intermolecular recognition site; other site 743299007194 dimerization interface [polypeptide binding]; other site 743299007195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299007196 Walker A motif; other site 743299007197 ATP binding site [chemical binding]; other site 743299007198 Walker B motif; other site 743299007199 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743299007200 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743299007201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299007202 dimer interface [polypeptide binding]; other site 743299007203 phosphorylation site [posttranslational modification] 743299007204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299007205 ATP binding site [chemical binding]; other site 743299007206 Mg2+ binding site [ion binding]; other site 743299007207 G-X-G motif; other site 743299007208 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 743299007209 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 743299007210 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 743299007211 Walker A motif; other site 743299007212 ATP binding site [chemical binding]; other site 743299007213 Walker B motif; other site 743299007214 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 743299007215 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 743299007216 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 743299007217 shikimate binding site; other site 743299007218 NAD(P) binding site [chemical binding]; other site 743299007219 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 743299007220 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 743299007221 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743299007222 ferrochelatase; Reviewed; Region: hemH; PRK00035 743299007223 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 743299007224 C-terminal domain interface [polypeptide binding]; other site 743299007225 active site 743299007226 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 743299007227 active site 743299007228 N-terminal domain interface [polypeptide binding]; other site 743299007229 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 743299007230 putative catalytic site [active] 743299007231 putative phosphate binding site [ion binding]; other site 743299007232 active site 743299007233 metal binding site A [ion binding]; metal-binding site 743299007234 DNA binding site [nucleotide binding] 743299007235 putative AP binding site [nucleotide binding]; other site 743299007236 putative metal binding site B [ion binding]; other site 743299007237 putative glutathione S-transferase; Provisional; Region: PRK10357 743299007238 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299007239 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 743299007240 substrate binding pocket (H-site) [chemical binding]; other site 743299007241 N-terminal domain interface [polypeptide binding]; other site 743299007242 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 743299007243 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; cl01820 743299007244 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 743299007245 putative catalytic site [active] 743299007246 putative metal binding site [ion binding]; other site 743299007247 putative phosphate binding site [ion binding]; other site 743299007248 HemK family putative methylases; Region: hemK_fam; TIGR00536 743299007249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299007250 S-adenosylmethionine binding site [chemical binding]; other site 743299007251 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 743299007252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299007253 putative substrate translocation pore; other site 743299007254 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743299007255 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 743299007256 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 743299007257 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743299007258 active site 743299007259 HIGH motif; other site 743299007260 nucleotide binding site [chemical binding]; other site 743299007261 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 743299007262 KMSK motif region; other site 743299007263 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 743299007264 tRNA binding surface [nucleotide binding]; other site 743299007265 anticodon binding site; other site 743299007266 Sporulation related domain; Region: SPOR; pfam05036 743299007267 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 743299007268 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 743299007269 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 743299007270 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 743299007271 active site 743299007272 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 743299007273 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 743299007274 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743299007275 RNA binding surface [nucleotide binding]; other site 743299007276 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 743299007277 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 743299007278 Walker A/P-loop; other site 743299007279 ATP binding site [chemical binding]; other site 743299007280 Q-loop/lid; other site 743299007281 ABC transporter signature motif; other site 743299007282 Walker B; other site 743299007283 D-loop; other site 743299007284 H-loop/switch region; other site 743299007285 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 743299007286 anti sigma factor interaction site; other site 743299007287 regulatory phosphorylation site [posttranslational modification]; other site 743299007288 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 743299007289 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 743299007290 mce related protein; Region: MCE; pfam02470 743299007291 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 743299007292 Permease; Region: Permease; pfam02405 743299007293 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 743299007294 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 743299007295 Walker A/P-loop; other site 743299007296 ATP binding site [chemical binding]; other site 743299007297 Q-loop/lid; other site 743299007298 ABC transporter signature motif; other site 743299007299 Walker B; other site 743299007300 D-loop; other site 743299007301 H-loop/switch region; other site 743299007302 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 743299007303 spermidine synthase; Provisional; Region: PRK00811 743299007304 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 743299007305 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743299007306 catalytic core [active] 743299007307 response regulator GlrR; Provisional; Region: PRK15115 743299007308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743299007309 active site 743299007310 phosphorylation site [posttranslational modification] 743299007311 intermolecular recognition site; other site 743299007312 dimerization interface [polypeptide binding]; other site 743299007313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299007314 Walker A motif; other site 743299007315 ATP binding site [chemical binding]; other site 743299007316 Walker B motif; other site 743299007317 arginine finger; other site 743299007318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743299007319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743299007320 dimerization interface [polypeptide binding]; other site 743299007321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743299007322 dimer interface [polypeptide binding]; other site 743299007323 phosphorylation site [posttranslational modification] 743299007324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743299007325 ATP binding site [chemical binding]; other site 743299007326 Mg2+ binding site [ion binding]; other site 743299007327 G-X-G motif; other site 743299007328 oxidative damage protection protein; Provisional; Region: PRK05408 743299007329 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 743299007330 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743299007331 minor groove reading motif; other site 743299007332 helix-hairpin-helix signature motif; other site 743299007333 substrate binding pocket [chemical binding]; other site 743299007334 active site 743299007335 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 743299007336 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 743299007337 DNA binding and oxoG recognition site [nucleotide binding] 743299007338 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 743299007339 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 743299007340 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 743299007341 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 743299007342 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 743299007343 regulatory protein interface [polypeptide binding]; other site 743299007344 active site 743299007345 regulatory phosphorylation site [posttranslational modification]; other site 743299007346 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 743299007347 active site 743299007348 active pocket/dimerization site; other site 743299007349 phosphorylation site [posttranslational modification] 743299007350 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 743299007351 AAA domain; Region: AAA_18; pfam13238 743299007352 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 743299007353 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 743299007354 Hpr binding site; other site 743299007355 active site 743299007356 homohexamer subunit interaction site [polypeptide binding]; other site 743299007357 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 743299007358 active site 743299007359 phosphorylation site [posttranslational modification] 743299007360 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 743299007361 30S subunit binding site; other site 743299007362 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 743299007363 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 743299007364 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 743299007365 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 743299007366 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 743299007367 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 743299007368 Walker A/P-loop; other site 743299007369 ATP binding site [chemical binding]; other site 743299007370 Q-loop/lid; other site 743299007371 ABC transporter signature motif; other site 743299007372 Walker B; other site 743299007373 D-loop; other site 743299007374 H-loop/switch region; other site 743299007375 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 743299007376 OstA-like protein; Region: OstA; pfam03968 743299007377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 743299007378 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 743299007379 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 743299007380 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 743299007381 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 743299007382 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 743299007383 putative active site [active] 743299007384 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 743299007385 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 743299007386 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 743299007387 Substrate binding site; other site 743299007388 metal-binding site 743299007389 Phosphotransferase enzyme family; Region: APH; pfam01636 743299007390 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 743299007391 substrate binding site [chemical binding]; other site 743299007392 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 743299007393 OstA-like protein; Region: OstA; cl00844 743299007394 Organic solvent tolerance protein; Region: OstA_C; pfam04453 743299007395 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 743299007396 SurA N-terminal domain; Region: SurA_N; pfam09312 743299007397 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 743299007398 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 743299007399 ABC-2 type transporter; Region: ABC2_membrane; cl17235 743299007400 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 743299007401 BolA-like protein; Region: BolA; pfam01722 743299007402 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 743299007403 putative GSH binding site [chemical binding]; other site 743299007404 catalytic residues [active] 743299007405 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 743299007406 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 743299007407 hinge; other site 743299007408 active site 743299007409 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 743299007410 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 743299007411 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 743299007412 histidinol dehydrogenase; Region: hisD; TIGR00069 743299007413 NAD binding site [chemical binding]; other site 743299007414 dimerization interface [polypeptide binding]; other site 743299007415 product binding site; other site 743299007416 substrate binding site [chemical binding]; other site 743299007417 zinc binding site [ion binding]; other site 743299007418 catalytic residues [active] 743299007419 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 743299007420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743299007421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299007422 homodimer interface [polypeptide binding]; other site 743299007423 catalytic residue [active] 743299007424 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 743299007425 putative active site pocket [active] 743299007426 4-fold oligomerization interface [polypeptide binding]; other site 743299007427 metal binding residues [ion binding]; metal-binding site 743299007428 3-fold/trimer interface [polypeptide binding]; other site 743299007429 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 743299007430 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 743299007431 putative active site [active] 743299007432 oxyanion strand; other site 743299007433 catalytic triad [active] 743299007434 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 743299007435 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 743299007436 catalytic residues [active] 743299007437 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 743299007438 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 743299007439 substrate binding site [chemical binding]; other site 743299007440 glutamase interaction surface [polypeptide binding]; other site 743299007441 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 743299007442 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 743299007443 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 743299007444 metal binding site [ion binding]; metal-binding site 743299007445 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 743299007446 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 743299007447 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 743299007448 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 743299007449 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 743299007450 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743299007451 putative ADP-binding pocket [chemical binding]; other site 743299007452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299007453 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 743299007454 DNA-binding site [nucleotide binding]; DNA binding site 743299007455 RNA-binding motif; other site 743299007456 PAS domain S-box; Region: sensory_box; TIGR00229 743299007457 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743299007458 putative active site [active] 743299007459 heme pocket [chemical binding]; other site 743299007460 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743299007461 GAF domain; Region: GAF; pfam01590 743299007462 PAS domain; Region: PAS_9; pfam13426 743299007463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743299007464 putative active site [active] 743299007465 heme pocket [chemical binding]; other site 743299007466 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299007467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299007468 metal binding site [ion binding]; metal-binding site 743299007469 active site 743299007470 I-site; other site 743299007471 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299007472 potassium uptake protein; Region: kup; TIGR00794 743299007473 K+ potassium transporter; Region: K_trans; pfam02705 743299007474 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743299007475 dihydroorotase; Validated; Region: pyrC; PRK09357 743299007476 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 743299007477 active site 743299007478 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 743299007479 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 743299007480 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 743299007481 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743299007482 active site 743299007483 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 743299007484 hypothetical protein; Validated; Region: PRK00228 743299007485 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 743299007486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299007487 AAA domain; Region: AAA_22; pfam13401 743299007488 Walker A motif; other site 743299007489 ATP binding site [chemical binding]; other site 743299007490 Walker B motif; other site 743299007491 arginine finger; other site 743299007492 Winged helix-turn helix; Region: HTH_29; pfam13551 743299007493 Homeodomain-like domain; Region: HTH_32; pfam13565 743299007494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 743299007495 Integrase core domain; Region: rve; pfam00665 743299007496 Integrase core domain; Region: rve_3; pfam13683 743299007497 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 743299007498 metal ion-dependent adhesion site (MIDAS); other site 743299007499 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 743299007500 PRTRC system protein D; Region: PRTRC_D; TIGR03739 743299007501 Mg binding site [ion binding]; other site 743299007502 nucleotide binding site [chemical binding]; other site 743299007503 putative protofilament interface [polypeptide binding]; other site 743299007504 Uncharacterized conserved protein [Function unknown]; Region: COG0393 743299007505 PemK-like protein; Region: PemK; pfam02452 743299007506 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 743299007507 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 743299007508 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 743299007509 Domain of unknown function DUF29; Region: DUF29; pfam01724 743299007510 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 743299007511 oligomeric interface; other site 743299007512 putative active site [active] 743299007513 homodimer interface [polypeptide binding]; other site 743299007514 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 743299007515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743299007516 Coenzyme A binding pocket [chemical binding]; other site 743299007517 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 743299007518 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 743299007519 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 743299007520 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 743299007521 F plasmid transfer operon protein; Region: TraF; pfam13728 743299007522 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 743299007523 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743299007524 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743299007525 catalytic residue [active] 743299007526 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 743299007527 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743299007528 Zn2+ binding site [ion binding]; other site 743299007529 Mg2+ binding site [ion binding]; other site 743299007530 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 743299007531 RRXRR protein; Region: RRXRR; pfam14239 743299007532 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 743299007533 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 743299007534 active site 743299007535 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 743299007536 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 743299007537 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 743299007538 dimer interface [polypeptide binding]; other site 743299007539 ssDNA binding site [nucleotide binding]; other site 743299007540 tetramer (dimer of dimers) interface [polypeptide binding]; other site 743299007541 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 743299007542 active site 743299007543 metal binding site [ion binding]; metal-binding site 743299007544 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 743299007545 domain I; other site 743299007546 DNA binding groove [nucleotide binding] 743299007547 phosphate binding site [ion binding]; other site 743299007548 catalytic site [active] 743299007549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743299007550 Walker A motif; other site 743299007551 ATP binding site [chemical binding]; other site 743299007552 Walker B motif; other site 743299007553 arginine finger; other site 743299007554 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 743299007555 Peptidase family M50; Region: Peptidase_M50; pfam02163 743299007556 putative substrate binding region [chemical binding]; other site 743299007557 Methyltransferase domain; Region: Methyltransf_27; pfam13708 743299007558 5'-3' exonuclease (including N-terminal domain of PolI) [DNA replication, recombination, and repair]; Region: Exo; COG0258 743299007559 PIN domain of bacteriophage T3, T4 RNase H, T5-5'nuclease, and homologs; Region: PIN_T4-like; cd09860 743299007560 active site 743299007561 metal binding site 1 [ion binding]; metal-binding site 743299007562 5' ssDNA interaction site; other site 743299007563 3' ssDNA interaction site; other site 743299007564 metal binding site 2 [ion binding]; metal-binding site 743299007565 H3TH domain of bacteriophage T3, T4 RNase H, T5-5' nucleases, and homologs; Region: H3TH_T4-like; cd09899 743299007566 DNA binding site [nucleotide binding] 743299007567 metal binding site [ion binding]; metal-binding site 743299007568 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 743299007569 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743299007570 IHF dimer interface [polypeptide binding]; other site 743299007571 IHF - DNA interface [nucleotide binding]; other site 743299007572 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743299007573 IHF - DNA interface [nucleotide binding]; other site 743299007574 IHF dimer interface [polypeptide binding]; other site 743299007575 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743299007576 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 743299007577 active site 743299007578 DNA binding site [nucleotide binding] 743299007579 Int/Topo IB signature motif; other site 743299007580 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299007581 WGR domain; Region: WGR; cl01581 743299007582 hypothetical protein; Validated; Region: PRK08238 743299007583 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 743299007584 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 743299007585 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 743299007586 FAD binding domain; Region: FAD_binding_4; pfam01565 743299007587 short chain dehydrogenase; Provisional; Region: PRK07102 743299007588 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 743299007589 NAD(P) binding site [chemical binding]; other site 743299007590 active site 743299007591 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 743299007592 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 743299007593 putative NAD(P) binding site [chemical binding]; other site 743299007594 active site 743299007595 hypothetical protein; Provisional; Region: PRK07233 743299007596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743299007597 hydroxyglutarate oxidase; Provisional; Region: PRK11728 743299007598 Predicted membrane protein [Function unknown]; Region: COG2246 743299007599 GtrA-like protein; Region: GtrA; pfam04138 743299007600 Nuclease-related domain; Region: NERD; pfam08378 743299007601 PemK-like protein; Region: PemK; cl00995 743299007602 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 743299007603 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876 743299007604 TraU protein; Region: TraU; pfam06834 743299007605 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 743299007606 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 743299007607 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 743299007608 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 743299007609 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 743299007610 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 743299007611 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299007612 Type II/IV secretion system protein; Region: T2SE; pfam00437 743299007613 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743299007614 Walker A motif; other site 743299007615 ATP binding site [chemical binding]; other site 743299007616 Walker B motif; other site 743299007617 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743299007618 type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747 743299007619 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 743299007620 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 743299007621 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 743299007622 TraK protein; Region: TraK; pfam06586 743299007623 TraE protein; Region: TraE; cl05060 743299007624 TraL protein; Region: TraL; cl06278 743299007625 RRXRR protein; Region: RRXRR; pfam14239 743299007626 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 743299007627 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 743299007628 active site 743299007629 hypothetical protein; Provisional; Region: PRK01184 743299007630 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 743299007631 active site 743299007632 Zn binding site [ion binding]; other site 743299007633 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 743299007634 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 743299007635 active site 743299007636 interdomain interaction site; other site 743299007637 putative metal-binding site [ion binding]; other site 743299007638 nucleotide binding site [chemical binding]; other site 743299007639 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 743299007640 domain I; other site 743299007641 DNA binding groove [nucleotide binding] 743299007642 phosphate binding site [ion binding]; other site 743299007643 domain II; other site 743299007644 domain III; other site 743299007645 nucleotide binding site [chemical binding]; other site 743299007646 catalytic site [active] 743299007647 domain IV; other site 743299007648 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 743299007649 Helix-turn-helix domain; Region: HTH_36; pfam13730 743299007650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743299007651 putative DNA binding site [nucleotide binding]; other site 743299007652 putative Zn2+ binding site [ion binding]; other site 743299007653 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 743299007654 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 743299007655 integrase; Provisional; Region: PRK09692 743299007656 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 743299007657 active site 743299007658 Int/Topo IB signature motif; other site 743299007659 glutathione synthetase; Provisional; Region: PRK05246 743299007660 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 743299007661 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 743299007662 Glutamate-cysteine ligase; Region: GshA; pfam08886 743299007663 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 743299007664 citrate synthase; Provisional; Region: PRK14036 743299007665 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 743299007666 dimer interface [polypeptide binding]; other site 743299007667 active site 743299007668 citrylCoA binding site [chemical binding]; other site 743299007669 oxalacetate/citrate binding site [chemical binding]; other site 743299007670 coenzyme A binding site [chemical binding]; other site 743299007671 catalytic triad [active] 743299007672 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 743299007673 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743299007674 E3 interaction surface; other site 743299007675 lipoyl attachment site [posttranslational modification]; other site 743299007676 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743299007677 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 743299007678 E3 interaction surface; other site 743299007679 lipoyl attachment site [posttranslational modification]; other site 743299007680 e3 binding domain; Region: E3_binding; pfam02817 743299007681 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 743299007682 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 743299007683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743299007684 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743299007685 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 743299007686 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 743299007687 alpha subunit interface [polypeptide binding]; other site 743299007688 TPP binding site [chemical binding]; other site 743299007689 heterodimer interface [polypeptide binding]; other site 743299007690 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743299007691 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 743299007692 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 743299007693 tetramer interface [polypeptide binding]; other site 743299007694 TPP-binding site [chemical binding]; other site 743299007695 heterodimer interface [polypeptide binding]; other site 743299007696 phosphorylation loop region [posttranslational modification] 743299007697 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 743299007698 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 743299007699 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 743299007700 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 743299007701 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 743299007702 23S rRNA interface [nucleotide binding]; other site 743299007703 L3 interface [polypeptide binding]; other site 743299007704 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 743299007705 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 743299007706 dimer interface [polypeptide binding]; other site 743299007707 FMN binding site [chemical binding]; other site 743299007708 HI0933-like protein; Region: HI0933_like; pfam03486 743299007709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743299007710 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 743299007711 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 743299007712 active site 743299007713 HIGH motif; other site 743299007714 dimer interface [polypeptide binding]; other site 743299007715 KMSKS motif; other site 743299007716 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743299007717 RNA binding surface [nucleotide binding]; other site 743299007718 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 743299007719 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 743299007720 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743299007721 Soluble P-type ATPase [General function prediction only]; Region: COG4087 743299007722 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 743299007723 tetramerization interface [polypeptide binding]; other site 743299007724 active site 743299007725 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 743299007726 G1 box; other site 743299007727 GTP/Mg2+ binding site [chemical binding]; other site 743299007728 Switch I region; other site 743299007729 G2 box; other site 743299007730 G3 box; other site 743299007731 Switch II region; other site 743299007732 G4 box; other site 743299007733 G5 box; other site 743299007734 voltage-gated potassium channel; Provisional; Region: PRK10537 743299007735 Ion channel; Region: Ion_trans_2; pfam07885 743299007736 TrkA-N domain; Region: TrkA_N; pfam02254 743299007737 DNA polymerase I; Provisional; Region: PRK05755 743299007738 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 743299007739 active site 743299007740 metal binding site 1 [ion binding]; metal-binding site 743299007741 putative 5' ssDNA interaction site; other site 743299007742 metal binding site 3; metal-binding site 743299007743 metal binding site 2 [ion binding]; metal-binding site 743299007744 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 743299007745 putative DNA binding site [nucleotide binding]; other site 743299007746 putative metal binding site [ion binding]; other site 743299007747 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 743299007748 active site 743299007749 catalytic site [active] 743299007750 substrate binding site [chemical binding]; other site 743299007751 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 743299007752 active site 743299007753 DNA binding site [nucleotide binding] 743299007754 catalytic site [active] 743299007755 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 743299007756 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 743299007757 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 743299007758 Phosphotransferase enzyme family; Region: APH; pfam01636 743299007759 putative active site [active] 743299007760 putative substrate binding site [chemical binding]; other site 743299007761 ATP binding site [chemical binding]; other site 743299007762 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 743299007763 Helix-hairpin-helix motif; Region: HHH; pfam00633 743299007764 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 743299007765 Part of AAA domain; Region: AAA_19; pfam13245 743299007766 Family description; Region: UvrD_C_2; pfam13538 743299007767 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 743299007768 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743299007769 HSP70 interaction site [polypeptide binding]; other site 743299007770 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 743299007771 substrate binding site [polypeptide binding]; other site 743299007772 dimer interface [polypeptide binding]; other site 743299007773 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 743299007774 hypothetical protein; Provisional; Region: PRK08609 743299007775 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 743299007776 active site 743299007777 primer binding site [nucleotide binding]; other site 743299007778 NTP binding site [chemical binding]; other site 743299007779 metal binding triad [ion binding]; metal-binding site 743299007780 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 743299007781 active site 743299007782 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 743299007783 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743299007784 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 743299007785 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 743299007786 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 743299007787 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 743299007788 putative hydrophobic ligand binding site [chemical binding]; other site 743299007789 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743299007790 Predicted flavoprotein [General function prediction only]; Region: COG0431 743299007791 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 743299007792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743299007793 Coenzyme A binding pocket [chemical binding]; other site 743299007794 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 743299007795 hypothetical protein; Provisional; Region: PRK02268 743299007796 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743299007797 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 743299007798 putative dimer interface [polypeptide binding]; other site 743299007799 HTH domain; Region: HTH_11; pfam08279 743299007800 Predicted transcriptional regulator [Transcription]; Region: COG2378 743299007801 WYL domain; Region: WYL; pfam13280 743299007802 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 743299007803 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 743299007804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743299007805 Coenzyme A binding pocket [chemical binding]; other site 743299007806 Nitrogen regulatory protein P-II; Region: P-II; cl00412 743299007807 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 743299007808 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 743299007809 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 743299007810 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743299007811 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 743299007812 intersubunit interface [polypeptide binding]; other site 743299007813 active site 743299007814 zinc binding site [ion binding]; other site 743299007815 Na+ binding site [ion binding]; other site 743299007816 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 743299007817 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 743299007818 metal ion-dependent adhesion site (MIDAS); other site 743299007819 MoxR-like ATPases [General function prediction only]; Region: COG0714 743299007820 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 743299007821 Walker A motif; other site 743299007822 ATP binding site [chemical binding]; other site 743299007823 Walker B motif; other site 743299007824 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 743299007825 ParA-like protein; Provisional; Region: PHA02518 743299007826 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743299007827 Magnesium ion binding site [ion binding]; other site 743299007828 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 743299007829 DCoH dimer interaction site [polypeptide binding]; other site 743299007830 aromatic arch; other site 743299007831 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 743299007832 DCoH tetramer interaction site [polypeptide binding]; other site 743299007833 substrate binding site [chemical binding]; other site 743299007834 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 743299007835 Ferritin-like domain; Region: Ferritin; pfam00210 743299007836 dinuclear metal binding motif [ion binding]; other site 743299007837 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 743299007838 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 743299007839 Hexamer interface [polypeptide binding]; other site 743299007840 Hexagonal pore residue; other site 743299007841 Hexagonal pore; other site 743299007842 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 743299007843 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 743299007844 Hexamer interface [polypeptide binding]; other site 743299007845 Hexagonal pore residue; other site 743299007846 Hexagonal pore; other site 743299007847 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 743299007848 Hexamer/Pentamer interface [polypeptide binding]; other site 743299007849 central pore; other site 743299007850 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 743299007851 Hexamer/Pentamer interface [polypeptide binding]; other site 743299007852 central pore; other site 743299007853 carboxysome shell carbonic anhydrase; Region: shell_carb_anhy; TIGR02701 743299007854 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 743299007855 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 743299007856 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 743299007857 multimerization interface [polypeptide binding]; other site 743299007858 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 743299007859 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 743299007860 dimer interface [polypeptide binding]; other site 743299007861 catalytic residue [active] 743299007862 metal binding site [ion binding]; metal-binding site 743299007863 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743299007864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743299007865 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 743299007866 putative dimerization interface [polypeptide binding]; other site 743299007867 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743299007868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299007869 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743299007870 putative substrate translocation pore; other site 743299007871 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 743299007872 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 743299007873 Cl- selectivity filter; other site 743299007874 Cl- binding residues [ion binding]; other site 743299007875 pore gating glutamate residue; other site 743299007876 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 743299007877 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 743299007878 Cl- selectivity filter; other site 743299007879 Cl- binding residues [ion binding]; other site 743299007880 pore gating glutamate residue; other site 743299007881 dimer interface [polypeptide binding]; other site 743299007882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743299007883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743299007884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743299007885 dimerization interface [polypeptide binding]; other site 743299007886 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 743299007887 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 743299007888 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743299007889 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 743299007890 NAD binding site [chemical binding]; other site 743299007891 homodimer interface [polypeptide binding]; other site 743299007892 active site 743299007893 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 743299007894 Domain interface; other site 743299007895 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 743299007896 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 743299007897 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743299007898 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743299007899 metal binding site [ion binding]; metal-binding site 743299007900 active site 743299007901 I-site; other site 743299007902 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743299007903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299007904 putative substrate translocation pore; other site 743299007905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 743299007906 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 743299007907 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 743299007908 putative transposase OrfB; Reviewed; Region: PHA02517 743299007909 HTH-like domain; Region: HTH_21; pfam13276 743299007910 Integrase core domain; Region: rve; pfam00665 743299007911 Integrase core domain; Region: rve_3; pfam13683 743299007912 Protein of unknown function (DUF421); Region: DUF421; cl00990 743299007913 DDE superfamily endonuclease; Region: DDE_3; pfam13358 743299007914 putative transposase OrfB; Reviewed; Region: PHA02517 743299007915 HTH-like domain; Region: HTH_21; pfam13276 743299007916 Integrase core domain; Region: rve; pfam00665 743299007917 Integrase core domain; Region: rve_3; pfam13683 743299007918 Protein of unknown function (DUF421); Region: DUF421; cl00990 743299007919 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743299007920 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743299007921 substrate binding pocket [chemical binding]; other site 743299007922 membrane-bound complex binding site; other site 743299007923 hinge residues; other site 743299007924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743299007925 dimer interface [polypeptide binding]; other site 743299007926 conserved gate region; other site 743299007927 putative PBP binding loops; other site 743299007928 ABC-ATPase subunit interface; other site 743299007929 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 743299007930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743299007931 Walker A/P-loop; other site 743299007932 ATP binding site [chemical binding]; other site 743299007933 Q-loop/lid; other site 743299007934 ABC transporter signature motif; other site 743299007935 Walker B; other site 743299007936 D-loop; other site 743299007937 H-loop/switch region; other site 743299007938 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 743299007939 homotrimer interaction site [polypeptide binding]; other site 743299007940 putative active site [active] 743299007941 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 743299007942 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743299007943 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743299007944 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 743299007945 putative DNA binding site [nucleotide binding]; other site 743299007946 putative Zn2+ binding site [ion binding]; other site 743299007947 AsnC family; Region: AsnC_trans_reg; pfam01037 743299007948 Part of AAA domain; Region: AAA_19; pfam13245 743299007949 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 743299007950 AAA domain; Region: AAA_12; pfam13087 743299007951 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 743299007952 putative active site [active] 743299007953 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 743299007954 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 743299007955 active site 743299007956 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 743299007957 Catalytic domain of Protein Kinases; Region: PKc; cd00180 743299007958 active site 743299007959 ATP binding site [chemical binding]; other site 743299007960 substrate binding site [chemical binding]; other site 743299007961 activation loop (A-loop); other site 743299007962 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 743299007963 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 743299007964 glutaminase active site [active] 743299007965 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 743299007966 dimer interface [polypeptide binding]; other site 743299007967 active site 743299007968 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 743299007969 dimer interface [polypeptide binding]; other site 743299007970 active site 743299007971 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 743299007972 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 743299007973 Substrate binding site; other site 743299007974 Mg++ binding site; other site 743299007975 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 743299007976 active site 743299007977 substrate binding site [chemical binding]; other site 743299007978 CoA binding site [chemical binding]; other site 743299007979 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 743299007980 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 743299007981 gamma subunit interface [polypeptide binding]; other site 743299007982 epsilon subunit interface [polypeptide binding]; other site 743299007983 LBP interface [polypeptide binding]; other site 743299007984 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 743299007985 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 743299007986 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 743299007987 alpha subunit interaction interface [polypeptide binding]; other site 743299007988 Walker A motif; other site 743299007989 ATP binding site [chemical binding]; other site 743299007990 Walker B motif; other site 743299007991 inhibitor binding site; inhibition site 743299007992 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 743299007993 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 743299007994 core domain interface [polypeptide binding]; other site 743299007995 delta subunit interface [polypeptide binding]; other site 743299007996 epsilon subunit interface [polypeptide binding]; other site 743299007997 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 743299007998 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 743299007999 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 743299008000 beta subunit interaction interface [polypeptide binding]; other site 743299008001 Walker A motif; other site 743299008002 ATP binding site [chemical binding]; other site 743299008003 Walker B motif; other site 743299008004 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 743299008005 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 743299008006 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 743299008007 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 743299008008 ATP synthase, F0 subunit b; Region: ATP_synt_b; TIGR01144 743299008009 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 743299008010 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 743299008011 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 743299008012 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 743299008013 ParB-like nuclease domain; Region: ParBc; pfam02195 743299008014 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 743299008015 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743299008016 P-loop; other site 743299008017 Magnesium ion binding site [ion binding]; other site 743299008018 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743299008019 Magnesium ion binding site [ion binding]; other site 743299008020 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 743299008021 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 743299008022 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 743299008023 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 743299008024 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 743299008025 NlpE N-terminal domain; Region: NlpE; pfam04170 743299008026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743299008027 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 743299008028 MPT binding site; other site 743299008029 trimer interface [polypeptide binding]; other site 743299008030 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 743299008031 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 743299008032 Cl binding site [ion binding]; other site 743299008033 oligomer interface [polypeptide binding]; other site 743299008034 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 743299008035 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 743299008036 Cl binding site [ion binding]; other site 743299008037 oligomer interface [polypeptide binding]; other site 743299008038 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 743299008039 oligomer interface [polypeptide binding]; other site 743299008040 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 743299008041 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 743299008042 Cl binding site [ion binding]; other site 743299008043 oligomer interface [polypeptide binding]; other site 743299008044 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 743299008045 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 743299008046 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 743299008047 Cysteine-rich domain; Region: CCG; pfam02754 743299008048 Cysteine-rich domain; Region: CCG; pfam02754 743299008049 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 743299008050 FAD binding domain; Region: FAD_binding_4; pfam01565 743299008051 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 743299008052 FAD binding domain; Region: FAD_binding_4; pfam01565 743299008053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 743299008054 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 743299008055 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 743299008056 TPP-binding site [chemical binding]; other site 743299008057 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 743299008058 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 743299008059 Transcriptional regulator [Transcription]; Region: IclR; COG1414 743299008060 Bacterial transcriptional regulator; Region: IclR; pfam01614 743299008061 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 743299008062 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 743299008063 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 743299008064 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 743299008065 Probable Catalytic site; other site 743299008066 metal-binding site 743299008067 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743299008068 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 743299008069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 743299008070 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 743299008071 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 743299008072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 743299008073 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 743299008074 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 743299008075 Transposase; Region: DEDD_Tnp_IS110; pfam01548 743299008076 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 743299008077 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 743299008078 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 743299008079 putative active site [active] 743299008080 putative NTP binding site [chemical binding]; other site 743299008081 putative nucleic acid binding site [nucleotide binding]; other site 743299008082 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 743299008083 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 743299008084 active site 743299008085 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 743299008086 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 743299008087 Ligand binding site; other site 743299008088 Putative Catalytic site; other site 743299008089 DXD motif; other site 743299008090 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 743299008091 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 743299008092 NAD binding site [chemical binding]; other site 743299008093 homodimer interface [polypeptide binding]; other site 743299008094 active site 743299008095 substrate binding site [chemical binding]; other site 743299008096 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 743299008097 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743299008098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299008099 NAD(P) binding site [chemical binding]; other site 743299008100 active site 743299008101 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 743299008102 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743299008103 Rhamnan synthesis protein F; Region: RgpF; pfam05045 743299008104 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 743299008105 Methyltransferase domain; Region: Methyltransf_24; pfam13578 743299008106 GtrA-like protein; Region: GtrA; pfam04138 743299008107 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 743299008108 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 743299008109 Ligand binding site; other site 743299008110 Putative Catalytic site; other site 743299008111 DXD motif; other site 743299008112 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 743299008113 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 743299008114 Methyltransferase domain; Region: Methyltransf_23; pfam13489 743299008115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743299008116 S-adenosylmethionine binding site [chemical binding]; other site 743299008117 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 743299008118 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 743299008119 Probable Catalytic site; other site 743299008120 metal-binding site 743299008121 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 743299008122 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 743299008123 Probable Catalytic site; other site 743299008124 metal-binding site 743299008125 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 743299008126 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 743299008127 Walker A/P-loop; other site 743299008128 ATP binding site [chemical binding]; other site 743299008129 Q-loop/lid; other site 743299008130 ABC transporter signature motif; other site 743299008131 Walker B; other site 743299008132 D-loop; other site 743299008133 H-loop/switch region; other site 743299008134 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 743299008135 ABC-2 type transporter; Region: ABC2_membrane; cl17235 743299008136 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 743299008137 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 743299008138 putative active site [active] 743299008139 homotetrameric interface [polypeptide binding]; other site 743299008140 metal binding site [ion binding]; metal-binding site 743299008141 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 743299008142 PemK-like protein; Region: PemK; pfam02452 743299008143 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743299008144 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 743299008145 Coenzyme A binding pocket [chemical binding]; other site 743299008146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 743299008147 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 743299008148 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 743299008149 NAD binding site [chemical binding]; other site 743299008150 substrate binding site [chemical binding]; other site 743299008151 homodimer interface [polypeptide binding]; other site 743299008152 active site 743299008153 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 743299008154 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 743299008155 NADP binding site [chemical binding]; other site 743299008156 active site 743299008157 putative substrate binding site [chemical binding]; other site 743299008158 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 743299008159 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 743299008160 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 743299008161 substrate binding site; other site 743299008162 tetramer interface; other site 743299008163 benzoate transport; Region: 2A0115; TIGR00895 743299008164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743299008165 putative substrate translocation pore; other site 743299008166 TonB C terminal; Region: TonB_2; pfam13103 743299008167 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 743299008168 dimer interface [polypeptide binding]; other site 743299008169 active site 743299008170 Schiff base residues; other site 743299008171 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 743299008172 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 743299008173 active site 743299008174 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 743299008175 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 743299008176 domain interfaces; other site 743299008177 active site 743299008178 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 743299008179 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 743299008180 nucleotide binding site/active site [active] 743299008181 HIT family signature motif; other site 743299008182 catalytic residue [active] 743299008183 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 743299008184 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743299008185 inhibitor-cofactor binding pocket; inhibition site 743299008186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743299008187 catalytic residue [active] 743299008188 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 743299008189 thiamine phosphate binding site [chemical binding]; other site 743299008190 active site 743299008191 pyrophosphate binding site [ion binding]; other site 743299008192 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 743299008193 dimer interface [polypeptide binding]; other site 743299008194 substrate binding site [chemical binding]; other site 743299008195 ATP binding site [chemical binding]; other site 743299008196 Bacterial PH domain; Region: DUF304; pfam03703 743299008197 Cytochrome c [Energy production and conversion]; Region: COG3258 743299008198 Cytochrome c; Region: Cytochrom_C; cl11414 743299008199 Cytochrome c; Region: Cytochrom_C; cl11414 743299008200 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 743299008201 cytochrome b; Provisional; Region: CYTB; MTH00145 743299008202 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743299008203 Qi binding site; other site 743299008204 intrachain domain interface; other site 743299008205 interchain domain interface [polypeptide binding]; other site 743299008206 heme bH binding site [chemical binding]; other site 743299008207 heme bL binding site [chemical binding]; other site 743299008208 Qo binding site; other site 743299008209 interchain domain interface [polypeptide binding]; other site 743299008210 intrachain domain interface; other site 743299008211 Qi binding site; other site 743299008212 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 743299008213 Qo binding site; other site 743299008214 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 743299008215 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 743299008216 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 743299008217 [2Fe-2S] cluster binding site [ion binding]; other site 743299008218 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 743299008219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743299008220 NAD(P) binding site [chemical binding]; other site 743299008221 active site 743299008222 Cytochrome c; Region: Cytochrom_C; cl11414 743299008223 Cytochrome c; Region: Cytochrom_C; cl11414 743299008224 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 743299008225 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 743299008226 FMN binding site [chemical binding]; other site 743299008227 substrate binding site [chemical binding]; other site 743299008228 putative catalytic residue [active] 743299008229 SCP-2 sterol transfer family; Region: SCP2; cl01225 743299008230 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 743299008231 Peptidase family U32; Region: Peptidase_U32; pfam01136 743299008232 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 743299008233 Protein of unknown function DUF116; Region: DUF116; cl00800 743299008234 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 743299008235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743299008236 FeS/SAM binding site; other site 743299008237 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 743299008238 ATP cone domain; Region: ATP-cone; pfam03477 743299008239 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 743299008240 Class III ribonucleotide reductase; Region: RNR_III; cd01675 743299008241 effector binding site; other site 743299008242 active site 743299008243 Zn binding site [ion binding]; other site