-- dump date 20140618_185030 -- class Genbank::misc_feature -- table misc_feature_note -- id note 243159000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 243159000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 243159000003 putative DNA binding surface [nucleotide binding]; other site 243159000004 dimer interface [polypeptide binding]; other site 243159000005 beta-clamp/clamp loader binding surface; other site 243159000006 beta-clamp/translesion DNA polymerase binding surface; other site 243159000007 recombination protein F; Reviewed; Region: recF; PRK00064 243159000008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159000009 Walker A/P-loop; other site 243159000010 ATP binding site [chemical binding]; other site 243159000011 Q-loop/lid; other site 243159000012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159000013 ABC transporter signature motif; other site 243159000014 Walker B; other site 243159000015 D-loop; other site 243159000016 H-loop/switch region; other site 243159000017 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 243159000018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159000019 ATP binding site [chemical binding]; other site 243159000020 Mg2+ binding site [ion binding]; other site 243159000021 G-X-G motif; other site 243159000022 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 243159000023 anchoring element; other site 243159000024 dimer interface [polypeptide binding]; other site 243159000025 ATP binding site [chemical binding]; other site 243159000026 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 243159000027 active site 243159000028 putative metal-binding site [ion binding]; other site 243159000029 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 243159000030 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 243159000031 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 243159000032 FAD binding pocket [chemical binding]; other site 243159000033 FAD binding motif [chemical binding]; other site 243159000034 phosphate binding motif [ion binding]; other site 243159000035 beta-alpha-beta structure motif; other site 243159000036 NAD binding pocket [chemical binding]; other site 243159000037 Iron coordination center [ion binding]; other site 243159000038 Uncharacterized secreted protein [Function unknown]; Region: COG5430 243159000039 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 243159000040 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 243159000041 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 243159000042 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 243159000043 PapC C-terminal domain; Region: PapC_C; pfam13953 243159000044 Spore Coat Protein U domain; Region: SCPU; pfam05229 243159000045 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 243159000046 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 243159000047 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 243159000048 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 243159000049 Switch I; other site 243159000050 Switch II; other site 243159000051 septum site-determining protein MinC; Region: minC; TIGR01222 243159000052 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 243159000053 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 243159000054 Ferredoxin [Energy production and conversion]; Region: COG1146 243159000055 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 243159000056 DNA topoisomerase I; Validated; Region: PRK06599 243159000057 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 243159000058 active site 243159000059 interdomain interaction site; other site 243159000060 putative metal-binding site [ion binding]; other site 243159000061 nucleotide binding site [chemical binding]; other site 243159000062 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 243159000063 domain I; other site 243159000064 DNA binding groove [nucleotide binding] 243159000065 phosphate binding site [ion binding]; other site 243159000066 domain II; other site 243159000067 domain III; other site 243159000068 nucleotide binding site [chemical binding]; other site 243159000069 catalytic site [active] 243159000070 domain IV; other site 243159000071 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243159000072 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 243159000073 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243159000074 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243159000075 Protein of unknown function (DUF494); Region: DUF494; cl01103 243159000076 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 243159000077 DNA protecting protein DprA; Region: dprA; TIGR00732 243159000078 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 243159000079 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243159000080 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 243159000081 active site 243159000082 catalytic residues [active] 243159000083 metal binding site [ion binding]; metal-binding site 243159000084 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 243159000085 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 243159000086 putative active site [active] 243159000087 substrate binding site [chemical binding]; other site 243159000088 putative cosubstrate binding site; other site 243159000089 catalytic site [active] 243159000090 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 243159000091 substrate binding site [chemical binding]; other site 243159000092 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 243159000093 putative RNA binding site [nucleotide binding]; other site 243159000094 16S rRNA methyltransferase B; Provisional; Region: PRK10901 243159000095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159000096 S-adenosylmethionine binding site [chemical binding]; other site 243159000097 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 243159000098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243159000099 dimerization interface [polypeptide binding]; other site 243159000100 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243159000101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243159000102 dimer interface [polypeptide binding]; other site 243159000103 phosphorylation site [posttranslational modification] 243159000104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159000105 ATP binding site [chemical binding]; other site 243159000106 G-X-G motif; other site 243159000107 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243159000108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159000109 active site 243159000110 phosphorylation site [posttranslational modification] 243159000111 intermolecular recognition site; other site 243159000112 dimerization interface [polypeptide binding]; other site 243159000113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159000114 Walker A motif; other site 243159000115 ATP binding site [chemical binding]; other site 243159000116 Walker B motif; other site 243159000117 arginine finger; other site 243159000118 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243159000119 HAMP domain; Region: HAMP; pfam00672 243159000120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243159000121 dimer interface [polypeptide binding]; other site 243159000122 phosphorylation site [posttranslational modification] 243159000123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159000124 ATP binding site [chemical binding]; other site 243159000125 Mg2+ binding site [ion binding]; other site 243159000126 G-X-G motif; other site 243159000127 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243159000128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159000129 active site 243159000130 phosphorylation site [posttranslational modification] 243159000131 intermolecular recognition site; other site 243159000132 dimerization interface [polypeptide binding]; other site 243159000133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159000134 Walker A motif; other site 243159000135 ATP binding site [chemical binding]; other site 243159000136 Walker B motif; other site 243159000137 arginine finger; other site 243159000138 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243159000139 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243159000140 active site 243159000141 Trp docking motif [polypeptide binding]; other site 243159000142 PQQ-like domain; Region: PQQ_2; pfam13360 243159000143 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 243159000144 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 243159000145 trmE is a tRNA modification GTPase; Region: trmE; cd04164 243159000146 G1 box; other site 243159000147 GTP/Mg2+ binding site [chemical binding]; other site 243159000148 Switch I region; other site 243159000149 G2 box; other site 243159000150 Switch II region; other site 243159000151 G3 box; other site 243159000152 G4 box; other site 243159000153 G5 box; other site 243159000154 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 243159000155 membrane protein insertase; Provisional; Region: PRK01318 243159000156 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 243159000157 Haemolytic domain; Region: Haemolytic; pfam01809 243159000158 Ribonuclease P; Region: Ribonuclease_P; pfam00825 243159000159 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 243159000160 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 243159000161 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243159000162 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243159000163 ABC transporter; Region: ABC_tran_2; pfam12848 243159000164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243159000165 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 243159000166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159000167 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 243159000168 dimerization interface [polypeptide binding]; other site 243159000169 substrate binding pocket [chemical binding]; other site 243159000170 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 243159000171 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159000172 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243159000173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159000174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243159000175 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 243159000176 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 243159000177 gating phenylalanine in ion channel; other site 243159000178 Domain of unknown function (DUF1791); Region: DUF1791; cl00621 243159000179 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 243159000180 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243159000181 TQO small subunit DoxD; Region: DoxD; pfam04173 243159000182 TQO small subunit DoxA; Region: DoxA; pfam07680 243159000183 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243159000184 active site residue [active] 243159000185 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243159000186 active site residue [active] 243159000187 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243159000188 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243159000189 catalytic residues [active] 243159000190 TQO small subunit DoxD; Region: DoxD; pfam04173 243159000191 TQO small subunit DoxA; Region: DoxA; pfam07680 243159000192 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 243159000193 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243159000194 Sulphur transport; Region: Sulf_transp; pfam04143 243159000195 MarC family integral membrane protein; Region: MarC; cl00919 243159000196 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 243159000197 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 243159000198 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 243159000199 dimer interface [polypeptide binding]; other site 243159000200 anticodon binding site; other site 243159000201 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 243159000202 homodimer interface [polypeptide binding]; other site 243159000203 motif 1; other site 243159000204 active site 243159000205 motif 2; other site 243159000206 GAD domain; Region: GAD; pfam02938 243159000207 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 243159000208 motif 3; other site 243159000209 quinolinate synthetase; Provisional; Region: PRK09375 243159000210 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243159000211 putative acyl-acceptor binding pocket; other site 243159000212 hypothetical protein; Validated; Region: PRK00110 243159000213 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 243159000214 active site 243159000215 putative DNA-binding cleft [nucleotide binding]; other site 243159000216 dimer interface [polypeptide binding]; other site 243159000217 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 243159000218 RuvA N terminal domain; Region: RuvA_N; pfam01330 243159000219 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 243159000220 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 243159000221 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 243159000222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159000223 Walker A motif; other site 243159000224 ATP binding site [chemical binding]; other site 243159000225 Walker B motif; other site 243159000226 arginine finger; other site 243159000227 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 243159000228 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243159000229 active site 243159000230 TolQ protein; Region: tolQ; TIGR02796 243159000231 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243159000232 TolR protein; Region: tolR; TIGR02801 243159000233 TolA protein; Region: tolA_full; TIGR02794 243159000234 TolA protein; Region: tolA_full; TIGR02794 243159000235 Gram-negative bacterial tonB protein; Region: TonB; cl10048 243159000236 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 243159000237 TolB amino-terminal domain; Region: TolB_N; pfam04052 243159000238 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243159000239 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 243159000240 Ligand Binding Site [chemical binding]; other site 243159000241 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 243159000242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159000243 FeS/SAM binding site; other site 243159000244 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243159000245 Tetratricopeptide repeat; Region: TPR_6; pfam13174 243159000246 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243159000247 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243159000248 ligand binding site [chemical binding]; other site 243159000249 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 243159000250 Bacterial sugar transferase; Region: Bac_transf; pfam02397 243159000251 Chain length determinant protein; Region: Wzz; pfam02706 243159000252 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243159000253 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243159000254 putative DNA binding site [nucleotide binding]; other site 243159000255 putative Zn2+ binding site [ion binding]; other site 243159000256 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 243159000257 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 243159000258 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243159000259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159000260 S-adenosylmethionine binding site [chemical binding]; other site 243159000261 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243159000262 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 243159000263 active site 243159000264 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159000265 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 243159000266 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 243159000267 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159000268 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 243159000269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243159000270 active site 243159000271 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 243159000272 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 243159000273 putative active site [active] 243159000274 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 243159000275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243159000276 non-specific DNA binding site [nucleotide binding]; other site 243159000277 salt bridge; other site 243159000278 sequence-specific DNA binding site [nucleotide binding]; other site 243159000279 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 243159000280 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 243159000281 Fic family protein [Function unknown]; Region: COG3177 243159000282 Fic/DOC family; Region: Fic; pfam02661 243159000283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 243159000284 putative DNA binding site [nucleotide binding]; other site 243159000285 putative Zn2+ binding site [ion binding]; other site 243159000286 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 243159000287 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 243159000288 Predicted membrane protein [Function unknown]; Region: COG2259 243159000289 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243159000290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243159000291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243159000292 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 243159000293 catalytic triad [active] 243159000294 conserved cis-peptide bond; other site 243159000295 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 243159000296 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243159000297 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243159000298 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243159000299 Walker A/P-loop; other site 243159000300 ATP binding site [chemical binding]; other site 243159000301 Q-loop/lid; other site 243159000302 ABC transporter signature motif; other site 243159000303 Walker B; other site 243159000304 D-loop; other site 243159000305 H-loop/switch region; other site 243159000306 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243159000307 DevC protein; Region: devC; TIGR01185 243159000308 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 243159000309 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 243159000310 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 243159000311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159000312 ATP binding site [chemical binding]; other site 243159000313 Mg2+ binding site [ion binding]; other site 243159000314 G-X-G motif; other site 243159000315 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243159000316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159000317 active site 243159000318 phosphorylation site [posttranslational modification] 243159000319 intermolecular recognition site; other site 243159000320 dimerization interface [polypeptide binding]; other site 243159000321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243159000322 DNA binding site [nucleotide binding] 243159000323 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243159000324 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243159000325 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243159000326 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159000327 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 243159000328 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 243159000329 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 243159000330 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 243159000331 META domain; Region: META; pfam03724 243159000332 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243159000333 Sel1-like repeats; Region: SEL1; smart00671 243159000334 Sel1-like repeats; Region: SEL1; smart00671 243159000335 Sel1-like repeats; Region: SEL1; smart00671 243159000336 Sel1-like repeats; Region: SEL1; smart00671 243159000337 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243159000338 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243159000339 ligand binding site [chemical binding]; other site 243159000340 flexible hinge region; other site 243159000341 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 243159000342 non-specific DNA interactions [nucleotide binding]; other site 243159000343 DNA binding site [nucleotide binding] 243159000344 sequence specific DNA binding site [nucleotide binding]; other site 243159000345 putative cAMP binding site [chemical binding]; other site 243159000346 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 243159000347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243159000348 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 243159000349 UGMP family protein; Validated; Region: PRK09604 243159000350 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 243159000351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159000352 binding surface 243159000353 TPR motif; other site 243159000354 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 243159000355 Dihydroneopterin aldolase; Region: FolB; smart00905 243159000356 active site 243159000357 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 243159000358 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243159000359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159000360 FeS/SAM binding site; other site 243159000361 NifU-like domain; Region: NifU; cl00484 243159000362 pteridine reductase; Provisional; Region: PRK09135 243159000363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243159000364 NAD(P) binding site [chemical binding]; other site 243159000365 active site 243159000366 Uncharacterized conserved protein [Function unknown]; Region: COG1565 243159000367 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 243159000368 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 243159000369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159000370 FeS/SAM binding site; other site 243159000371 HemN C-terminal domain; Region: HemN_C; pfam06969 243159000372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243159000373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159000374 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 243159000375 putative dimerization interface [polypeptide binding]; other site 243159000376 outer membrane porin, OprD family; Region: OprD; pfam03573 243159000377 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243159000378 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243159000379 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243159000380 putative active site [active] 243159000381 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 243159000382 FAD binding domain; Region: FAD_binding_4; pfam01565 243159000383 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 243159000384 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 243159000385 active site 243159000386 dimer interface [polypeptide binding]; other site 243159000387 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 243159000388 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 243159000389 active site 243159000390 nucleotide binding site [chemical binding]; other site 243159000391 HIGH motif; other site 243159000392 KMSKS motif; other site 243159000393 hypothetical protein; Reviewed; Region: PRK12497 243159000394 LppC putative lipoprotein; Region: LppC; pfam04348 243159000395 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 243159000396 putative ligand binding site [chemical binding]; other site 243159000397 Predicted methyltransferases [General function prediction only]; Region: COG0313 243159000398 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 243159000399 putative SAM binding site [chemical binding]; other site 243159000400 putative homodimer interface [polypeptide binding]; other site 243159000401 BRO family, N-terminal domain; Region: Bro-N; cl10591 243159000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159000403 S-adenosylmethionine binding site [chemical binding]; other site 243159000404 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 243159000405 active site residue [active] 243159000406 Protein of unknown function (DUF423); Region: DUF423; pfam04241 243159000407 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 243159000408 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 243159000409 amphipathic channel; other site 243159000410 Asn-Pro-Ala signature motifs; other site 243159000411 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243159000412 catalytic core [active] 243159000413 spermidine synthase; Provisional; Region: PRK00811 243159000414 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 243159000415 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 243159000416 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 243159000417 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 243159000418 Walker A/P-loop; other site 243159000419 ATP binding site [chemical binding]; other site 243159000420 Q-loop/lid; other site 243159000421 ABC transporter signature motif; other site 243159000422 Walker B; other site 243159000423 D-loop; other site 243159000424 H-loop/switch region; other site 243159000425 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243159000426 Permease; Region: Permease; pfam02405 243159000427 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243159000428 mce related protein; Region: MCE; pfam02470 243159000429 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 243159000430 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243159000431 anti sigma factor interaction site; other site 243159000432 regulatory phosphorylation site [posttranslational modification]; other site 243159000433 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243159000434 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243159000435 Walker A/P-loop; other site 243159000436 ATP binding site [chemical binding]; other site 243159000437 Q-loop/lid; other site 243159000438 ABC transporter signature motif; other site 243159000439 Walker B; other site 243159000440 D-loop; other site 243159000441 H-loop/switch region; other site 243159000442 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243159000443 RNA binding surface [nucleotide binding]; other site 243159000444 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 243159000445 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 243159000446 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 243159000447 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243159000448 active site 243159000449 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 243159000450 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 243159000451 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 243159000452 Sporulation related domain; Region: SPOR; cl10051 243159000453 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 243159000454 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 243159000455 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243159000456 active site 243159000457 HIGH motif; other site 243159000458 nucleotide binding site [chemical binding]; other site 243159000459 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 243159000460 KMSK motif region; other site 243159000461 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 243159000462 tRNA binding surface [nucleotide binding]; other site 243159000463 anticodon binding site; other site 243159000464 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243159000465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159000466 putative substrate translocation pore; other site 243159000467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159000468 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 243159000469 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243159000470 dimerization interface [polypeptide binding]; other site 243159000471 HemK family putative methylases; Region: hemK_fam; TIGR00536 243159000472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159000473 S-adenosylmethionine binding site [chemical binding]; other site 243159000474 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243159000475 putative catalytic site [active] 243159000476 putative metal binding site [ion binding]; other site 243159000477 putative phosphate binding site [ion binding]; other site 243159000478 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 243159000479 putative glutathione S-transferase; Provisional; Region: PRK10357 243159000480 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243159000481 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 243159000482 N-terminal domain interface [polypeptide binding]; other site 243159000483 dimer interface [polypeptide binding]; other site 243159000484 substrate binding pocket (H-site) [chemical binding]; other site 243159000485 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 243159000486 putative catalytic site [active] 243159000487 putative phosphate binding site [ion binding]; other site 243159000488 active site 243159000489 metal binding site A [ion binding]; metal-binding site 243159000490 DNA binding site [nucleotide binding] 243159000491 putative AP binding site [nucleotide binding]; other site 243159000492 putative metal binding site B [ion binding]; other site 243159000493 ferrochelatase; Reviewed; Region: hemH; PRK00035 243159000494 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 243159000495 C-terminal domain interface [polypeptide binding]; other site 243159000496 active site 243159000497 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 243159000498 active site 243159000499 N-terminal domain interface [polypeptide binding]; other site 243159000500 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 243159000501 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243159000502 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 243159000503 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 243159000504 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 243159000505 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 243159000506 shikimate binding site; other site 243159000507 NAD(P) binding site [chemical binding]; other site 243159000508 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 243159000509 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243159000510 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243159000511 Walker A motif; other site 243159000512 ATP binding site [chemical binding]; other site 243159000513 Walker B motif; other site 243159000514 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243159000515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243159000516 dimer interface [polypeptide binding]; other site 243159000517 phosphorylation site [posttranslational modification] 243159000518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159000519 ATP binding site [chemical binding]; other site 243159000520 Mg2+ binding site [ion binding]; other site 243159000521 G-X-G motif; other site 243159000522 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243159000523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159000524 active site 243159000525 phosphorylation site [posttranslational modification] 243159000526 intermolecular recognition site; other site 243159000527 dimerization interface [polypeptide binding]; other site 243159000528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159000529 Walker A motif; other site 243159000530 ATP binding site [chemical binding]; other site 243159000531 Walker B motif; other site 243159000532 arginine finger; other site 243159000533 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 243159000534 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 243159000535 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 243159000536 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 243159000537 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 243159000538 CoA-binding site [chemical binding]; other site 243159000539 ATP-binding [chemical binding]; other site 243159000540 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 243159000541 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 243159000542 AMP binding site [chemical binding]; other site 243159000543 metal binding site [ion binding]; metal-binding site 243159000544 active site 243159000545 Stringent starvation protein B; Region: SspB; cl01120 243159000546 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 243159000547 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 243159000548 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243159000549 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243159000550 catalytic residue [active] 243159000551 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243159000552 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 243159000553 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 243159000554 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 243159000555 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 243159000556 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243159000557 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 243159000558 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243159000559 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 243159000560 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243159000561 carboxyltransferase (CT) interaction site; other site 243159000562 biotinylation site [posttranslational modification]; other site 243159000563 Dehydroquinase class II; Region: DHquinase_II; pfam01220 243159000564 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 243159000565 trimer interface [polypeptide binding]; other site 243159000566 active site 243159000567 dimer interface [polypeptide binding]; other site 243159000568 Predicted transcriptional regulators [Transcription]; Region: COG1733 243159000569 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 243159000570 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 243159000571 dinuclear metal binding motif [ion binding]; other site 243159000572 cell division protein FtsZ; Validated; Region: PRK09330 243159000573 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 243159000574 nucleotide binding site [chemical binding]; other site 243159000575 SulA interaction site; other site 243159000576 cell division protein FtsA; Region: ftsA; TIGR01174 243159000577 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243159000578 nucleotide binding site [chemical binding]; other site 243159000579 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 243159000580 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243159000581 Cell division protein FtsA; Region: FtsA; pfam14450 243159000582 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 243159000583 Cell division protein FtsQ; Region: FtsQ; pfam03799 243159000584 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 243159000585 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 243159000586 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243159000587 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 243159000588 FAD binding domain; Region: FAD_binding_4; pfam01565 243159000589 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 243159000590 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 243159000591 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243159000592 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243159000593 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243159000594 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 243159000595 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 243159000596 active site 243159000597 homodimer interface [polypeptide binding]; other site 243159000598 cell division protein FtsW; Region: ftsW; TIGR02614 243159000599 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 243159000600 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243159000601 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243159000602 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 243159000603 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 243159000604 Mg++ binding site [ion binding]; other site 243159000605 putative catalytic motif [active] 243159000606 putative substrate binding site [chemical binding]; other site 243159000607 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 243159000608 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243159000609 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243159000610 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243159000611 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 243159000612 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243159000613 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243159000614 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 243159000615 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 243159000616 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243159000617 Cell division protein FtsL; Region: FtsL; pfam04999 243159000618 MraW methylase family; Region: Methyltransf_5; cl17771 243159000619 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 243159000620 cell division protein MraZ; Reviewed; Region: PRK00326 243159000621 MraZ protein; Region: MraZ; pfam02381 243159000622 MraZ protein; Region: MraZ; pfam02381 243159000623 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 243159000624 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 243159000625 metal binding triad [ion binding]; metal-binding site 243159000626 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 243159000627 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243159000628 Zn2+ binding site [ion binding]; other site 243159000629 Mg2+ binding site [ion binding]; other site 243159000630 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243159000631 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 243159000632 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 243159000633 acyl-activating enzyme (AAE) consensus motif; other site 243159000634 acyl-activating enzyme (AAE) consensus motif; other site 243159000635 putative AMP binding site [chemical binding]; other site 243159000636 putative active site [active] 243159000637 putative CoA binding site [chemical binding]; other site 243159000638 stringent starvation protein A; Provisional; Region: sspA; PRK09481 243159000639 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 243159000640 C-terminal domain interface [polypeptide binding]; other site 243159000641 putative GSH binding site (G-site) [chemical binding]; other site 243159000642 dimer interface [polypeptide binding]; other site 243159000643 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 243159000644 N-terminal domain interface [polypeptide binding]; other site 243159000645 dimer interface [polypeptide binding]; other site 243159000646 substrate binding pocket (H-site) [chemical binding]; other site 243159000647 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 243159000648 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 243159000649 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 243159000650 DEAD/DEAH box helicase; Region: DEAD; pfam00270 243159000651 ATP binding site [chemical binding]; other site 243159000652 putative Mg++ binding site [ion binding]; other site 243159000653 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 243159000654 SEC-C motif; Region: SEC-C; pfam02810 243159000655 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 243159000656 heterotetramer interface [polypeptide binding]; other site 243159000657 active site pocket [active] 243159000658 cleavage site 243159000659 hypothetical protein; Provisional; Region: PRK08999 243159000660 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 243159000661 active site 243159000662 8-oxo-dGMP binding site [chemical binding]; other site 243159000663 nudix motif; other site 243159000664 metal binding site [ion binding]; metal-binding site 243159000665 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 243159000666 thiamine phosphate binding site [chemical binding]; other site 243159000667 active site 243159000668 pyrophosphate binding site [ion binding]; other site 243159000669 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 243159000670 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 243159000671 Ligand binding site; other site 243159000672 Putative Catalytic site; other site 243159000673 DXD motif; other site 243159000674 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 243159000675 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 243159000676 putative active site [active] 243159000677 putative metal binding site [ion binding]; other site 243159000678 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243159000679 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159000680 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 243159000681 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 243159000682 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243159000683 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 243159000684 Probable Catalytic site; other site 243159000685 metal-binding site 243159000686 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 243159000687 putative metal binding site; other site 243159000688 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243159000689 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 243159000690 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 243159000691 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 243159000692 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 243159000693 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243159000694 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 243159000695 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 243159000696 putative acyl-acceptor binding pocket; other site 243159000697 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 243159000698 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243159000699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159000700 homodimer interface [polypeptide binding]; other site 243159000701 catalytic residue [active] 243159000702 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 243159000703 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 243159000704 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243159000705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159000706 S-adenosylmethionine binding site [chemical binding]; other site 243159000707 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 243159000708 comF family protein; Region: comF; TIGR00201 243159000709 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243159000710 active site 243159000711 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 243159000712 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 243159000713 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243159000714 catalytic residue [active] 243159000715 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 243159000716 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 243159000717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159000718 S-adenosylmethionine binding site [chemical binding]; other site 243159000719 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 243159000720 AAA domain; Region: AAA_26; pfam13500 243159000721 Peptidase family M48; Region: Peptidase_M48; cl12018 243159000722 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 243159000723 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 243159000724 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 243159000725 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 243159000726 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 243159000727 ribonuclease T; Provisional; Region: PRK05168 243159000728 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 243159000729 active site 243159000730 catalytic site [active] 243159000731 substrate binding site [chemical binding]; other site 243159000732 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 243159000733 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243159000734 catalytic loop [active] 243159000735 iron binding site [ion binding]; other site 243159000736 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 243159000737 FAD binding pocket [chemical binding]; other site 243159000738 FAD binding motif [chemical binding]; other site 243159000739 phosphate binding motif [ion binding]; other site 243159000740 beta-alpha-beta structure motif; other site 243159000741 NAD binding pocket [chemical binding]; other site 243159000742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243159000743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243159000744 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 243159000745 feedback inhibition sensing region; other site 243159000746 homohexameric interface [polypeptide binding]; other site 243159000747 nucleotide binding site [chemical binding]; other site 243159000748 N-acetyl-L-glutamate binding site [chemical binding]; other site 243159000749 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 243159000750 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243159000751 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159000752 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 243159000753 biotin synthase; Region: bioB; TIGR00433 243159000754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159000755 FeS/SAM binding site; other site 243159000756 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 243159000757 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 243159000758 YGGT family; Region: YGGT; pfam02325 243159000759 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 243159000760 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 243159000761 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 243159000762 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243159000763 catalytic residue [active] 243159000764 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 243159000765 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 243159000766 Walker A motif; other site 243159000767 ATP binding site [chemical binding]; other site 243159000768 Walker B motif; other site 243159000769 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 243159000770 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243159000771 Walker A motif; other site 243159000772 ATP binding site [chemical binding]; other site 243159000773 Walker B motif; other site 243159000774 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 243159000775 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 243159000776 DXD motif; other site 243159000777 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 243159000778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243159000779 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243159000780 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243159000781 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243159000782 ligand binding site [chemical binding]; other site 243159000783 flexible hinge region; other site 243159000784 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 243159000785 putative switch regulator; other site 243159000786 non-specific DNA interactions [nucleotide binding]; other site 243159000787 DNA binding site [nucleotide binding] 243159000788 sequence specific DNA binding site [nucleotide binding]; other site 243159000789 putative cAMP binding site [chemical binding]; other site 243159000790 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 243159000791 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 243159000792 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 243159000793 ATP-grasp domain; Region: ATP-grasp; pfam02222 243159000794 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 243159000795 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243159000796 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 243159000797 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 243159000798 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 243159000799 SmpB-tmRNA interface; other site 243159000800 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 243159000801 putative active site [active] 243159000802 catalytic site [active] 243159000803 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 243159000804 putative active site [active] 243159000805 catalytic site [active] 243159000806 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 243159000807 putative coenzyme Q binding site [chemical binding]; other site 243159000808 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 243159000809 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 243159000810 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243159000811 metal binding site 2 [ion binding]; metal-binding site 243159000812 putative DNA binding helix; other site 243159000813 metal binding site 1 [ion binding]; metal-binding site 243159000814 dimer interface [polypeptide binding]; other site 243159000815 structural Zn2+ binding site [ion binding]; other site 243159000816 gamma-glutamyl kinase; Provisional; Region: PRK05429 243159000817 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 243159000818 nucleotide binding site [chemical binding]; other site 243159000819 homotetrameric interface [polypeptide binding]; other site 243159000820 putative phosphate binding site [ion binding]; other site 243159000821 putative allosteric binding site; other site 243159000822 PUA domain; Region: PUA; pfam01472 243159000823 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 243159000824 GTP1/OBG; Region: GTP1_OBG; pfam01018 243159000825 Obg GTPase; Region: Obg; cd01898 243159000826 G1 box; other site 243159000827 GTP/Mg2+ binding site [chemical binding]; other site 243159000828 Switch I region; other site 243159000829 G2 box; other site 243159000830 G3 box; other site 243159000831 Switch II region; other site 243159000832 G4 box; other site 243159000833 G5 box; other site 243159000834 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 243159000835 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 243159000836 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 243159000837 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 243159000838 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 243159000839 Sulfate transporter family; Region: Sulfate_transp; pfam00916 243159000840 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 243159000841 active site clefts [active] 243159000842 zinc binding site [ion binding]; other site 243159000843 dimer interface [polypeptide binding]; other site 243159000844 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 243159000845 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 243159000846 THF binding site; other site 243159000847 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 243159000848 substrate binding site [chemical binding]; other site 243159000849 THF binding site; other site 243159000850 zinc-binding site [ion binding]; other site 243159000851 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 243159000852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159000853 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 243159000854 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 243159000855 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 243159000856 N-terminal domain interface [polypeptide binding]; other site 243159000857 dimer interface [polypeptide binding]; other site 243159000858 substrate binding pocket (H-site) [chemical binding]; other site 243159000859 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243159000860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159000861 S-adenosylmethionine binding site [chemical binding]; other site 243159000862 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 243159000863 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 243159000864 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 243159000865 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 243159000866 dimer interface [polypeptide binding]; other site 243159000867 active site 243159000868 glycine-pyridoxal phosphate binding site [chemical binding]; other site 243159000869 folate binding site [chemical binding]; other site 243159000870 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 243159000871 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 243159000872 ATP cone domain; Region: ATP-cone; pfam03477 243159000873 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 243159000874 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 243159000875 catalytic motif [active] 243159000876 Zn binding site [ion binding]; other site 243159000877 RibD C-terminal domain; Region: RibD_C; cl17279 243159000878 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 243159000879 Lumazine binding domain; Region: Lum_binding; pfam00677 243159000880 Lumazine binding domain; Region: Lum_binding; pfam00677 243159000881 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 243159000882 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 243159000883 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 243159000884 dimerization interface [polypeptide binding]; other site 243159000885 active site 243159000886 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 243159000887 homopentamer interface [polypeptide binding]; other site 243159000888 active site 243159000889 transcription antitermination factor NusB; Region: nusB; TIGR01951 243159000890 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 243159000891 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243159000892 Sel1 repeat; Region: Sel1; cl02723 243159000893 Sel1-like repeats; Region: SEL1; smart00671 243159000894 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 243159000895 ABC1 family; Region: ABC1; cl17513 243159000896 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 243159000897 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243159000898 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243159000899 ligand binding site [chemical binding]; other site 243159000900 elongation factor Tu; Reviewed; Region: PRK12735 243159000901 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 243159000902 G1 box; other site 243159000903 GEF interaction site [polypeptide binding]; other site 243159000904 GTP/Mg2+ binding site [chemical binding]; other site 243159000905 Switch I region; other site 243159000906 G2 box; other site 243159000907 G3 box; other site 243159000908 Switch II region; other site 243159000909 G4 box; other site 243159000910 G5 box; other site 243159000911 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 243159000912 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 243159000913 Antibiotic Binding Site [chemical binding]; other site 243159000914 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 243159000915 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 243159000916 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 243159000917 putative homodimer interface [polypeptide binding]; other site 243159000918 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 243159000919 heterodimer interface [polypeptide binding]; other site 243159000920 homodimer interface [polypeptide binding]; other site 243159000921 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 243159000922 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 243159000923 23S rRNA interface [nucleotide binding]; other site 243159000924 L7/L12 interface [polypeptide binding]; other site 243159000925 putative thiostrepton binding site; other site 243159000926 L25 interface [polypeptide binding]; other site 243159000927 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 243159000928 mRNA/rRNA interface [nucleotide binding]; other site 243159000929 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 243159000930 23S rRNA interface [nucleotide binding]; other site 243159000931 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 243159000932 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 243159000933 core dimer interface [polypeptide binding]; other site 243159000934 peripheral dimer interface [polypeptide binding]; other site 243159000935 L10 interface [polypeptide binding]; other site 243159000936 L11 interface [polypeptide binding]; other site 243159000937 putative EF-Tu interaction site [polypeptide binding]; other site 243159000938 putative EF-G interaction site [polypeptide binding]; other site 243159000939 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 243159000940 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 243159000941 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 243159000942 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 243159000943 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 243159000944 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 243159000945 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 243159000946 RPB3 interaction site [polypeptide binding]; other site 243159000947 RPB1 interaction site [polypeptide binding]; other site 243159000948 RPB11 interaction site [polypeptide binding]; other site 243159000949 RPB10 interaction site [polypeptide binding]; other site 243159000950 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 243159000951 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 243159000952 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 243159000953 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 243159000954 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 243159000955 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 243159000956 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 243159000957 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 243159000958 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 243159000959 DNA binding site [nucleotide binding] 243159000960 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 243159000961 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 243159000962 S17 interaction site [polypeptide binding]; other site 243159000963 S8 interaction site; other site 243159000964 16S rRNA interaction site [nucleotide binding]; other site 243159000965 streptomycin interaction site [chemical binding]; other site 243159000966 23S rRNA interaction site [nucleotide binding]; other site 243159000967 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 243159000968 30S ribosomal protein S7; Validated; Region: PRK05302 243159000969 elongation factor G; Reviewed; Region: PRK00007 243159000970 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 243159000971 G1 box; other site 243159000972 putative GEF interaction site [polypeptide binding]; other site 243159000973 GTP/Mg2+ binding site [chemical binding]; other site 243159000974 Switch I region; other site 243159000975 G2 box; other site 243159000976 G3 box; other site 243159000977 Switch II region; other site 243159000978 G4 box; other site 243159000979 G5 box; other site 243159000980 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 243159000981 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 243159000982 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243159000983 elongation factor Tu; Reviewed; Region: PRK12735 243159000984 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 243159000985 G1 box; other site 243159000986 GEF interaction site [polypeptide binding]; other site 243159000987 GTP/Mg2+ binding site [chemical binding]; other site 243159000988 Switch I region; other site 243159000989 G2 box; other site 243159000990 G3 box; other site 243159000991 Switch II region; other site 243159000992 G4 box; other site 243159000993 G5 box; other site 243159000994 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 243159000995 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 243159000996 Antibiotic Binding Site [chemical binding]; other site 243159000997 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 243159000998 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 243159000999 50S ribosomal protein L4, bacterial/organelle; Region: rplD_bact; TIGR03953 243159001000 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 243159001001 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 243159001002 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 243159001003 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 243159001004 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 243159001005 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 243159001006 protein-rRNA interface [nucleotide binding]; other site 243159001007 putative translocon binding site; other site 243159001008 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 243159001009 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 243159001010 G-X-X-G motif; other site 243159001011 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 243159001012 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 243159001013 23S rRNA interface [nucleotide binding]; other site 243159001014 5S rRNA interface [nucleotide binding]; other site 243159001015 putative antibiotic binding site [chemical binding]; other site 243159001016 L25 interface [polypeptide binding]; other site 243159001017 L27 interface [polypeptide binding]; other site 243159001018 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 243159001019 putative translocon interaction site; other site 243159001020 signal recognition particle (SRP54) interaction site; other site 243159001021 L23 interface [polypeptide binding]; other site 243159001022 trigger factor interaction site; other site 243159001023 23S rRNA interface [nucleotide binding]; other site 243159001024 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 243159001025 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 243159001026 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 243159001027 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 243159001028 RNA binding site [nucleotide binding]; other site 243159001029 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 243159001030 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 243159001031 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 243159001032 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 243159001033 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 243159001034 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 243159001035 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243159001036 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243159001037 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 243159001038 5S rRNA interface [nucleotide binding]; other site 243159001039 23S rRNA interface [nucleotide binding]; other site 243159001040 L5 interface [polypeptide binding]; other site 243159001041 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 243159001042 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 243159001043 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 243159001044 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 243159001045 23S rRNA binding site [nucleotide binding]; other site 243159001046 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 243159001047 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 243159001048 SecY translocase; Region: SecY; pfam00344 243159001049 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 243159001050 adenylate kinase; Reviewed; Region: adk; PRK00279 243159001051 AMP-binding site [chemical binding]; other site 243159001052 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 243159001053 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 243159001054 rRNA binding site [nucleotide binding]; other site 243159001055 predicted 30S ribosome binding site; other site 243159001056 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 243159001057 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 243159001058 30S ribosomal protein S13; Region: bact_S13; TIGR03631 243159001059 30S ribosomal protein S11; Validated; Region: PRK05309 243159001060 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 243159001061 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 243159001062 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243159001063 RNA binding surface [nucleotide binding]; other site 243159001064 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 243159001065 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 243159001066 alphaNTD homodimer interface [polypeptide binding]; other site 243159001067 alphaNTD - beta interaction site [polypeptide binding]; other site 243159001068 alphaNTD - beta' interaction site [polypeptide binding]; other site 243159001069 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 243159001070 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 243159001071 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 243159001072 trimer interface [polypeptide binding]; other site 243159001073 active site 243159001074 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 243159001075 Flavoprotein; Region: Flavoprotein; pfam02441 243159001076 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 243159001077 hypothetical protein; Reviewed; Region: PRK00024 243159001078 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 243159001079 MPN+ (JAMM) motif; other site 243159001080 Zinc-binding site [ion binding]; other site 243159001081 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 243159001082 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 243159001083 active site 243159001084 UDP-glycosyltransferase; Region: PLN02534 243159001085 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 243159001086 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243159001087 active site 243159001088 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 243159001089 glutathione reductase; Validated; Region: PRK06116 243159001090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243159001091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243159001092 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243159001093 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 243159001094 catalytic triad [active] 243159001095 dimer interface [polypeptide binding]; other site 243159001096 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243159001097 phosphoserine phosphatase SerB; Region: serB; TIGR00338 243159001098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243159001099 motif II; other site 243159001100 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 243159001101 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 243159001102 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159001103 ATP binding site [chemical binding]; other site 243159001104 putative Mg++ binding site [ion binding]; other site 243159001105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243159001106 nucleotide binding region [chemical binding]; other site 243159001107 ATP-binding site [chemical binding]; other site 243159001108 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 243159001109 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 243159001110 substrate binding site; other site 243159001111 dimer interface; other site 243159001112 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 243159001113 homotrimer interaction site [polypeptide binding]; other site 243159001114 zinc binding site [ion binding]; other site 243159001115 CDP-binding sites; other site 243159001116 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 243159001117 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 243159001118 Permutation of conserved domain; other site 243159001119 active site 243159001120 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 243159001121 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 243159001122 DNA binding residues [nucleotide binding] 243159001123 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 243159001124 dimer interface [polypeptide binding]; other site 243159001125 metal binding site [ion binding]; metal-binding site 243159001126 Smr domain; Region: Smr; pfam01713 243159001127 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 243159001128 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243159001129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243159001130 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 243159001131 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 243159001132 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 243159001133 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 243159001134 recombination factor protein RarA; Reviewed; Region: PRK13342 243159001135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159001136 Walker A motif; other site 243159001137 ATP binding site [chemical binding]; other site 243159001138 Walker B motif; other site 243159001139 arginine finger; other site 243159001140 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 243159001141 seryl-tRNA synthetase; Provisional; Region: PRK05431 243159001142 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 243159001143 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 243159001144 dimer interface [polypeptide binding]; other site 243159001145 active site 243159001146 motif 1; other site 243159001147 motif 2; other site 243159001148 motif 3; other site 243159001149 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 243159001150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243159001151 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243159001152 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243159001153 ribosome maturation protein RimP; Reviewed; Region: PRK00092 243159001154 Sm and related proteins; Region: Sm_like; cl00259 243159001155 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 243159001156 putative oligomer interface [polypeptide binding]; other site 243159001157 putative RNA binding site [nucleotide binding]; other site 243159001158 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 243159001159 NusA N-terminal domain; Region: NusA_N; pfam08529 243159001160 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 243159001161 RNA binding site [nucleotide binding]; other site 243159001162 homodimer interface [polypeptide binding]; other site 243159001163 NusA-like KH domain; Region: KH_5; pfam13184 243159001164 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 243159001165 G-X-X-G motif; other site 243159001166 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 243159001167 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 243159001168 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 243159001169 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 243159001170 translation initiation factor IF-2; Region: IF-2; TIGR00487 243159001171 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 243159001172 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 243159001173 G1 box; other site 243159001174 putative GEF interaction site [polypeptide binding]; other site 243159001175 GTP/Mg2+ binding site [chemical binding]; other site 243159001176 Switch I region; other site 243159001177 G2 box; other site 243159001178 G3 box; other site 243159001179 Switch II region; other site 243159001180 G4 box; other site 243159001181 G5 box; other site 243159001182 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 243159001183 Translation-initiation factor 2; Region: IF-2; pfam11987 243159001184 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 243159001185 Ribosome-binding factor A; Region: RBFA; pfam02033 243159001186 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 243159001187 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 243159001188 RNA binding site [nucleotide binding]; other site 243159001189 active site 243159001190 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 243159001191 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 243159001192 16S/18S rRNA binding site [nucleotide binding]; other site 243159001193 S13e-L30e interaction site [polypeptide binding]; other site 243159001194 25S rRNA binding site [nucleotide binding]; other site 243159001195 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 243159001196 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 243159001197 RNase E interface [polypeptide binding]; other site 243159001198 trimer interface [polypeptide binding]; other site 243159001199 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 243159001200 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 243159001201 RNase E interface [polypeptide binding]; other site 243159001202 trimer interface [polypeptide binding]; other site 243159001203 active site 243159001204 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 243159001205 putative nucleic acid binding region [nucleotide binding]; other site 243159001206 G-X-X-G motif; other site 243159001207 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 243159001208 RNA binding site [nucleotide binding]; other site 243159001209 domain interface; other site 243159001210 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 243159001211 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 243159001212 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 243159001213 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 243159001214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159001215 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 243159001216 RNA/DNA hybrid binding site [nucleotide binding]; other site 243159001217 active site 243159001218 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 243159001219 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 243159001220 active site 243159001221 catalytic site [active] 243159001222 substrate binding site [chemical binding]; other site 243159001223 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 243159001224 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243159001225 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 243159001226 dimer interface [polypeptide binding]; other site 243159001227 active site 243159001228 metal binding site [ion binding]; metal-binding site 243159001229 glutathione binding site [chemical binding]; other site 243159001230 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 243159001231 argininosuccinate synthase; Provisional; Region: PRK13820 243159001232 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 243159001233 ANP binding site [chemical binding]; other site 243159001234 Substrate Binding Site II [chemical binding]; other site 243159001235 Substrate Binding Site I [chemical binding]; other site 243159001236 ornithine carbamoyltransferase; Provisional; Region: PRK00779 243159001237 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243159001238 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243159001239 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243159001240 acetylornithine aminotransferase; Provisional; Region: PRK02627 243159001241 inhibitor-cofactor binding pocket; inhibition site 243159001242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159001243 catalytic residue [active] 243159001244 aspartate kinase; Reviewed; Region: PRK06635 243159001245 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 243159001246 putative nucleotide binding site [chemical binding]; other site 243159001247 putative catalytic residues [active] 243159001248 putative Mg ion binding site [ion binding]; other site 243159001249 putative aspartate binding site [chemical binding]; other site 243159001250 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 243159001251 putative allosteric regulatory site; other site 243159001252 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 243159001253 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 243159001254 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243159001255 Sel1-like repeats; Region: SEL1; smart00671 243159001256 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 243159001257 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 243159001258 putative active site [active] 243159001259 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 243159001260 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 243159001261 putative active site [active] 243159001262 transaldolase; Provisional; Region: PRK03903 243159001263 catalytic residue [active] 243159001264 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 243159001265 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 243159001266 NAD binding site [chemical binding]; other site 243159001267 homotetramer interface [polypeptide binding]; other site 243159001268 homodimer interface [polypeptide binding]; other site 243159001269 substrate binding site [chemical binding]; other site 243159001270 active site 243159001271 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 243159001272 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243159001273 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243159001274 catalytic residue [active] 243159001275 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243159001276 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243159001277 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243159001278 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243159001279 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 243159001280 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 243159001281 HIGH motif; other site 243159001282 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 243159001283 active site 243159001284 KMSKS motif; other site 243159001285 aconitate hydratase; Validated; Region: PRK07229 243159001286 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 243159001287 substrate binding site [chemical binding]; other site 243159001288 ligand binding site [chemical binding]; other site 243159001289 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 243159001290 substrate binding site [chemical binding]; other site 243159001291 isocitrate dehydrogenase; Validated; Region: PRK07362 243159001292 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 243159001293 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 243159001294 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 243159001295 CoA-ligase; Region: Ligase_CoA; pfam00549 243159001296 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 243159001297 CoA binding domain; Region: CoA_binding; pfam02629 243159001298 CoA-ligase; Region: Ligase_CoA; pfam00549 243159001299 NAD synthetase; Provisional; Region: PRK13981 243159001300 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 243159001301 multimer interface [polypeptide binding]; other site 243159001302 active site 243159001303 catalytic triad [active] 243159001304 protein interface 1 [polypeptide binding]; other site 243159001305 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 243159001306 homodimer interface [polypeptide binding]; other site 243159001307 NAD binding pocket [chemical binding]; other site 243159001308 ATP binding pocket [chemical binding]; other site 243159001309 Mg binding site [ion binding]; other site 243159001310 active-site loop [active] 243159001311 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243159001312 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243159001313 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 243159001314 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 243159001315 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243159001316 RNA binding surface [nucleotide binding]; other site 243159001317 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243159001318 active site 243159001319 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 243159001320 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 243159001321 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 243159001322 Cupin domain; Region: Cupin_2; pfam07883 243159001323 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 243159001324 dimer interface [polypeptide binding]; other site 243159001325 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 243159001326 catalytic residue [active] 243159001327 metal binding site [ion binding]; metal-binding site 243159001328 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 243159001329 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243159001330 motif II; other site 243159001331 methylthioribulose-1-phosphate dehydratase; Region: salvage_mtnB; TIGR03328 243159001332 intersubunit interface [polypeptide binding]; other site 243159001333 active site 243159001334 Zn2+ binding site [ion binding]; other site 243159001335 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 243159001336 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 243159001337 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 243159001338 active site 243159001339 catalytic residues [active] 243159001340 metal binding site [ion binding]; metal-binding site 243159001341 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243159001342 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 243159001343 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 243159001344 NAD binding site [chemical binding]; other site 243159001345 substrate binding site [chemical binding]; other site 243159001346 homodimer interface [polypeptide binding]; other site 243159001347 active site 243159001348 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 243159001349 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 243159001350 NADP binding site [chemical binding]; other site 243159001351 active site 243159001352 putative substrate binding site [chemical binding]; other site 243159001353 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 243159001354 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 243159001355 active site 243159001356 tetramer interface; other site 243159001357 Protein of unknown function (DUF502); Region: DUF502; cl01107 243159001358 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243159001359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159001360 active site 243159001361 phosphorylation site [posttranslational modification] 243159001362 intermolecular recognition site; other site 243159001363 dimerization interface [polypeptide binding]; other site 243159001364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159001365 Walker A motif; other site 243159001366 ATP binding site [chemical binding]; other site 243159001367 Walker B motif; other site 243159001368 arginine finger; other site 243159001369 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243159001370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243159001371 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243159001372 dimerization interface [polypeptide binding]; other site 243159001373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243159001374 dimer interface [polypeptide binding]; other site 243159001375 phosphorylation site [posttranslational modification] 243159001376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159001377 ATP binding site [chemical binding]; other site 243159001378 Mg2+ binding site [ion binding]; other site 243159001379 G-X-G motif; other site 243159001380 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 243159001381 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 243159001382 Walker A/P-loop; other site 243159001383 ATP binding site [chemical binding]; other site 243159001384 Q-loop/lid; other site 243159001385 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 243159001386 Q-loop/lid; other site 243159001387 ABC transporter signature motif; other site 243159001388 Walker B; other site 243159001389 D-loop; other site 243159001390 H-loop/switch region; other site 243159001391 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 243159001392 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 243159001393 Type III pantothenate kinase; Region: Pan_kinase; cl17198 243159001394 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 243159001395 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 243159001396 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 243159001397 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 243159001398 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 243159001399 putative catalytic cysteine [active] 243159001400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159001401 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243159001402 putative substrate translocation pore; other site 243159001403 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 243159001404 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 243159001405 Lipopolysaccharide-assembly; Region: LptE; cl01125 243159001406 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 243159001407 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 243159001408 HIGH motif; other site 243159001409 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243159001410 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243159001411 active site 243159001412 KMSKS motif; other site 243159001413 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 243159001414 tRNA binding surface [nucleotide binding]; other site 243159001415 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 243159001416 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243159001417 Uncharacterized conserved protein [Function unknown]; Region: COG2353 243159001418 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 243159001419 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 243159001420 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 243159001421 DNA binding site [nucleotide binding] 243159001422 H2TH interface [polypeptide binding]; other site 243159001423 putative catalytic residues [active] 243159001424 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 243159001425 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243159001426 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 243159001427 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 243159001428 glutamine synthetase; Provisional; Region: glnA; PRK09469 243159001429 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 243159001430 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 243159001431 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 243159001432 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 243159001433 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 243159001434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159001435 S-adenosylmethionine binding site [chemical binding]; other site 243159001436 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 243159001437 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243159001438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243159001439 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243159001440 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243159001441 DNA binding residues [nucleotide binding] 243159001442 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 243159001443 aminotransferase; Validated; Region: PRK08175 243159001444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243159001445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159001446 homodimer interface [polypeptide binding]; other site 243159001447 catalytic residue [active] 243159001448 homoserine dehydrogenase; Provisional; Region: PRK06349 243159001449 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 243159001450 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 243159001451 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 243159001452 threonine synthase; Reviewed; Region: PRK06721 243159001453 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 243159001454 homodimer interface [polypeptide binding]; other site 243159001455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159001456 catalytic residue [active] 243159001457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 243159001458 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 243159001459 DHH family; Region: DHH; pfam01368 243159001460 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 243159001461 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 243159001462 oligomeric interface; other site 243159001463 putative active site [active] 243159001464 homodimer interface [polypeptide binding]; other site 243159001465 peptide chain release factor 2; Validated; Region: prfB; PRK00578 243159001466 This domain is found in peptide chain release factors; Region: PCRF; smart00937 243159001467 RF-1 domain; Region: RF-1; pfam00472 243159001468 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 243159001469 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 243159001470 dimer interface [polypeptide binding]; other site 243159001471 putative anticodon binding site; other site 243159001472 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 243159001473 motif 1; other site 243159001474 active site 243159001475 motif 2; other site 243159001476 motif 3; other site 243159001477 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 243159001478 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243159001479 FtsX-like permease family; Region: FtsX; pfam02687 243159001480 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243159001481 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243159001482 Walker A/P-loop; other site 243159001483 ATP binding site [chemical binding]; other site 243159001484 Q-loop/lid; other site 243159001485 ABC transporter signature motif; other site 243159001486 Walker B; other site 243159001487 D-loop; other site 243159001488 H-loop/switch region; other site 243159001489 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 243159001490 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 243159001491 Competence protein; Region: Competence; pfam03772 243159001492 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243159001493 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243159001494 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243159001495 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 243159001496 putative acyl-acceptor binding pocket; other site 243159001497 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 243159001498 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 243159001499 Uncharacterized conserved protein [Function unknown]; Region: COG2835 243159001500 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 243159001501 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 243159001502 Ligand binding site; other site 243159001503 oligomer interface; other site 243159001504 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 243159001505 dimer interface [polypeptide binding]; other site 243159001506 substrate binding site [chemical binding]; other site 243159001507 metal binding sites [ion binding]; metal-binding site 243159001508 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 243159001509 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 243159001510 trimer interface [polypeptide binding]; other site 243159001511 putative metal binding site [ion binding]; other site 243159001512 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 243159001513 Uncharacterized conserved protein [Function unknown]; Region: COG3791 243159001514 SnoaL-like domain; Region: SnoaL_2; pfam12680 243159001515 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 243159001516 active site 243159001517 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 243159001518 Integrase core domain; Region: rve; pfam00665 243159001519 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 243159001520 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243159001521 active site 243159001522 DNA binding site [nucleotide binding] 243159001523 Int/Topo IB signature motif; other site 243159001524 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243159001525 integron integrase; Region: integrase_gron; TIGR02249 243159001526 active site 243159001527 DNA binding site [nucleotide binding] 243159001528 Int/Topo IB signature motif; other site 243159001529 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 243159001530 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 243159001531 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 243159001532 Int/Topo IB signature motif; other site 243159001533 Group II catalytic intron 243159001534 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 243159001535 putative uracil binding site [chemical binding]; other site 243159001536 putative active site [active] 243159001537 Uncharacterized conserved protein [Function unknown]; Region: COG0397 243159001538 hypothetical protein; Validated; Region: PRK00029 243159001539 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 243159001540 Clp amino terminal domain; Region: Clp_N; pfam02861 243159001541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159001542 Walker A motif; other site 243159001543 ATP binding site [chemical binding]; other site 243159001544 Walker B motif; other site 243159001545 arginine finger; other site 243159001546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159001547 Walker A motif; other site 243159001548 ATP binding site [chemical binding]; other site 243159001549 Walker B motif; other site 243159001550 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243159001551 Uncharacterized conserved protein [Function unknown]; Region: COG2127 243159001552 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243159001553 DJ-1 family protein; Region: not_thiJ; TIGR01383 243159001554 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 243159001555 conserved cys residue [active] 243159001556 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 243159001557 C-terminal peptidase (prc); Region: prc; TIGR00225 243159001558 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 243159001559 protein binding site [polypeptide binding]; other site 243159001560 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 243159001561 Catalytic dyad [active] 243159001562 Peptidase family M23; Region: Peptidase_M23; pfam01551 243159001563 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 243159001564 phosphoglyceromutase; Provisional; Region: PRK05434 243159001565 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 243159001566 homodimer interface [polypeptide binding]; other site 243159001567 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 243159001568 active site pocket [active] 243159001569 Protein required for attachment to host cells; Region: Host_attach; pfam10116 243159001570 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 243159001571 active site residue [active] 243159001572 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243159001573 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 243159001574 substrate binding site [chemical binding]; other site 243159001575 ATP binding site [chemical binding]; other site 243159001576 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 243159001577 S-adenosylmethionine synthetase; Validated; Region: PRK05250 243159001578 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 243159001579 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 243159001580 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 243159001581 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 243159001582 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 243159001583 homotetramer interface [polypeptide binding]; other site 243159001584 ligand binding site [chemical binding]; other site 243159001585 catalytic site [active] 243159001586 NAD binding site [chemical binding]; other site 243159001587 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 243159001588 FAD binding site [chemical binding]; other site 243159001589 phosphoribulokinase; Provisional; Region: PRK15453 243159001590 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 243159001591 active site 243159001592 Domain of unknown function (DUF814); Region: DUF814; pfam05670 243159001593 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 243159001594 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243159001595 active site 243159001596 nucleotide binding site [chemical binding]; other site 243159001597 HIGH motif; other site 243159001598 KMSKS motif; other site 243159001599 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 243159001600 ligand-binding site [chemical binding]; other site 243159001601 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243159001602 active site 243159001603 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 243159001604 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 243159001605 ring oligomerisation interface [polypeptide binding]; other site 243159001606 ATP/Mg binding site [chemical binding]; other site 243159001607 stacking interactions; other site 243159001608 hinge regions; other site 243159001609 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 243159001610 oligomerisation interface [polypeptide binding]; other site 243159001611 mobile loop; other site 243159001612 roof hairpin; other site 243159001613 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243159001614 Tannase and feruloyl esterase; Region: Tannase; pfam07519 243159001615 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 243159001616 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 243159001617 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 243159001618 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 243159001619 DsbD alpha interface [polypeptide binding]; other site 243159001620 catalytic residues [active] 243159001621 Zinc-finger domain; Region: zf-CHCC; cl01821 243159001622 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 243159001623 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 243159001624 homodimer interface [polypeptide binding]; other site 243159001625 substrate-cofactor binding pocket; other site 243159001626 catalytic residue [active] 243159001627 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 243159001628 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243159001629 metal binding triad; other site 243159001630 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243159001631 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243159001632 metal binding triad; other site 243159001633 TIGR02099 family protein; Region: TIGR02099 243159001634 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 243159001635 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243159001636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243159001637 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243159001638 nitrilase; Region: PLN02798 243159001639 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 243159001640 putative active site [active] 243159001641 catalytic triad [active] 243159001642 dimer interface [polypeptide binding]; other site 243159001643 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 243159001644 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 243159001645 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 243159001646 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 243159001647 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243159001648 putative catalytic residue [active] 243159001649 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 243159001650 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 243159001651 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243159001652 active site 243159001653 HIGH motif; other site 243159001654 nucleotide binding site [chemical binding]; other site 243159001655 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243159001656 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 243159001657 active site 243159001658 KMSKS motif; other site 243159001659 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 243159001660 tRNA binding surface [nucleotide binding]; other site 243159001661 anticodon binding site; other site 243159001662 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243159001663 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 243159001664 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 243159001665 active site 243159001666 Riboflavin kinase; Region: Flavokinase; smart00904 243159001667 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 243159001668 integral membrane protein MviN; Region: mviN; TIGR01695 243159001669 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 243159001670 hypothetical protein; Provisional; Region: PRK11820 243159001671 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 243159001672 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 243159001673 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 243159001674 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 243159001675 catalytic site [active] 243159001676 G-X2-G-X-G-K; other site 243159001677 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 243159001678 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 243159001679 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243159001680 Zn2+ binding site [ion binding]; other site 243159001681 Mg2+ binding site [ion binding]; other site 243159001682 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 243159001683 synthetase active site [active] 243159001684 NTP binding site [chemical binding]; other site 243159001685 metal binding site [ion binding]; metal-binding site 243159001686 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 243159001687 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 243159001688 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 243159001689 homotrimer interaction site [polypeptide binding]; other site 243159001690 putative active site [active] 243159001691 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 243159001692 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 243159001693 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 243159001694 ssDNA binding site; other site 243159001695 generic binding surface II; other site 243159001696 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159001697 ATP binding site [chemical binding]; other site 243159001698 putative Mg++ binding site [ion binding]; other site 243159001699 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243159001700 nucleotide binding region [chemical binding]; other site 243159001701 ATP-binding site [chemical binding]; other site 243159001702 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243159001703 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243159001704 protoporphyrinogen oxidase; Region: PLN02576 243159001705 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243159001706 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243159001707 Domain of unknown function DUF20; Region: UPF0118; pfam01594 243159001708 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 243159001709 putative ligand binding pocket/active site [active] 243159001710 putative metal binding site [ion binding]; other site 243159001711 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 243159001712 AMMECR1; Region: AMMECR1; pfam01871 243159001713 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 243159001714 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159001715 FeS/SAM binding site; other site 243159001716 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243159001717 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 243159001718 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 243159001719 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 243159001720 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 243159001721 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 243159001722 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 243159001723 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 243159001724 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 243159001725 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 243159001726 helicase 45; Provisional; Region: PTZ00424 243159001727 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243159001728 ATP binding site [chemical binding]; other site 243159001729 Mg++ binding site [ion binding]; other site 243159001730 motif III; other site 243159001731 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243159001732 nucleotide binding region [chemical binding]; other site 243159001733 ATP-binding site [chemical binding]; other site 243159001734 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 243159001735 putative RNA binding site [nucleotide binding]; other site 243159001736 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243159001737 DNA-binding site [nucleotide binding]; DNA binding site 243159001738 RNA-binding motif; other site 243159001739 primosome assembly protein PriA; Validated; Region: PRK05580 243159001740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159001741 ATP binding site [chemical binding]; other site 243159001742 putative Mg++ binding site [ion binding]; other site 243159001743 helicase superfamily c-terminal domain; Region: HELICc; smart00490 243159001744 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 243159001745 UbiA prenyltransferase family; Region: UbiA; pfam01040 243159001746 Chorismate lyase; Region: Chor_lyase; cl01230 243159001747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243159001748 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 243159001749 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243159001750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159001751 FeS/SAM binding site; other site 243159001752 TRAM domain; Region: TRAM; cl01282 243159001753 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 243159001754 PhoH-like protein; Region: PhoH; pfam02562 243159001755 metal-binding heat shock protein; Provisional; Region: PRK00016 243159001756 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 243159001757 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243159001758 Transporter associated domain; Region: CorC_HlyC; smart01091 243159001759 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 243159001760 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 243159001761 putative active site [active] 243159001762 catalytic triad [active] 243159001763 putative dimer interface [polypeptide binding]; other site 243159001764 peptidase PmbA; Provisional; Region: PRK11040 243159001765 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 243159001766 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 243159001767 intersubunit interface [polypeptide binding]; other site 243159001768 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 243159001769 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 243159001770 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 243159001771 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 243159001772 ABC-ATPase subunit interface; other site 243159001773 dimer interface [polypeptide binding]; other site 243159001774 putative PBP binding regions; other site 243159001775 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 243159001776 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 243159001777 putative PBP binding regions; other site 243159001778 ABC-ATPase subunit interface; other site 243159001779 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243159001780 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 243159001781 putative NAD(P) binding site [chemical binding]; other site 243159001782 active site 243159001783 putative substrate binding site [chemical binding]; other site 243159001784 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 243159001785 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 243159001786 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 243159001787 putative ADP-binding pocket [chemical binding]; other site 243159001788 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159001789 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243159001790 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243159001791 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243159001792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159001793 Walker A/P-loop; other site 243159001794 ATP binding site [chemical binding]; other site 243159001795 Q-loop/lid; other site 243159001796 ABC transporter signature motif; other site 243159001797 Walker B; other site 243159001798 D-loop; other site 243159001799 H-loop/switch region; other site 243159001800 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 243159001801 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243159001802 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 243159001803 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 243159001804 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243159001805 catalytic core [active] 243159001806 Helix-turn-helix domain; Region: HTH_31; pfam13560 243159001807 non-specific DNA binding site [nucleotide binding]; other site 243159001808 salt bridge; other site 243159001809 sequence-specific DNA binding site [nucleotide binding]; other site 243159001810 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243159001811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159001812 S-adenosylmethionine binding site [chemical binding]; other site 243159001813 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 243159001814 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 243159001815 substrate binding site [chemical binding]; other site 243159001816 ligand binding site [chemical binding]; other site 243159001817 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 243159001818 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 243159001819 substrate binding site [chemical binding]; other site 243159001820 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 243159001821 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 243159001822 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 243159001823 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 243159001824 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243159001825 active site 243159001826 dimer interface [polypeptide binding]; other site 243159001827 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 243159001828 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 243159001829 potential catalytic triad [active] 243159001830 conserved cys residue [active] 243159001831 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 243159001832 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 243159001833 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 243159001834 cytochrome o ubiquinol oxidase, subunit I; Region: CyoB; TIGR02843 243159001835 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 243159001836 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 243159001837 Subunit I/III interface [polypeptide binding]; other site 243159001838 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 243159001839 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 243159001840 UbiA prenyltransferase family; Region: UbiA; pfam01040 243159001841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159001842 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243159001843 putative substrate translocation pore; other site 243159001844 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 243159001845 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 243159001846 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 243159001847 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243159001848 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 243159001849 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243159001850 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 243159001851 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 243159001852 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243159001853 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243159001854 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 243159001855 IMP binding site; other site 243159001856 dimer interface [polypeptide binding]; other site 243159001857 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 243159001858 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 243159001859 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 243159001860 catalytic site [active] 243159001861 subunit interface [polypeptide binding]; other site 243159001862 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 243159001863 thiS-thiF/thiG interaction site; other site 243159001864 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 243159001865 ThiS interaction site; other site 243159001866 putative active site [active] 243159001867 tetramer interface [polypeptide binding]; other site 243159001868 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 243159001869 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243159001870 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243159001871 aromatic acid decarboxylase; Validated; Region: PRK05920 243159001872 Flavoprotein; Region: Flavoprotein; pfam02441 243159001873 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 243159001874 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 243159001875 Walker A/P-loop; other site 243159001876 ATP binding site [chemical binding]; other site 243159001877 Q-loop/lid; other site 243159001878 ABC transporter signature motif; other site 243159001879 Walker B; other site 243159001880 D-loop; other site 243159001881 H-loop/switch region; other site 243159001882 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 243159001883 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243159001884 Permease; Region: Permease; pfam02405 243159001885 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 243159001886 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243159001887 putative catalytic site [active] 243159001888 putative phosphate binding site [ion binding]; other site 243159001889 putative metal binding site [ion binding]; other site 243159001890 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 243159001891 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 243159001892 ATP binding site [chemical binding]; other site 243159001893 substrate interface [chemical binding]; other site 243159001894 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 243159001895 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 243159001896 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243159001897 Walker A/P-loop; other site 243159001898 ATP binding site [chemical binding]; other site 243159001899 Q-loop/lid; other site 243159001900 ABC transporter signature motif; other site 243159001901 Walker B; other site 243159001902 D-loop; other site 243159001903 H-loop/switch region; other site 243159001904 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243159001905 catalytic residues [active] 243159001906 transcription termination factor Rho; Provisional; Region: rho; PRK09376 243159001907 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 243159001908 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 243159001909 RNA binding site [nucleotide binding]; other site 243159001910 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 243159001911 multimer interface [polypeptide binding]; other site 243159001912 Walker A motif; other site 243159001913 ATP binding site [chemical binding]; other site 243159001914 Walker B motif; other site 243159001915 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 243159001916 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 243159001917 Malic enzyme, N-terminal domain; Region: malic; pfam00390 243159001918 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 243159001919 NAD(P) binding pocket [chemical binding]; other site 243159001920 Domain of unknown function DUF20; Region: UPF0118; pfam01594 243159001921 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243159001922 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 243159001923 6-phosphogluconate dehydratase; Region: edd; TIGR01196 243159001924 LabA_like proteins; Region: LabA; cd10911 243159001925 Uncharacterized conserved protein [Function unknown]; Region: COG1432 243159001926 putative metal binding site [ion binding]; other site 243159001927 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243159001928 RNA binding site [nucleotide binding]; other site 243159001929 N-acetylglutamate synthase; Validated; Region: PRK05279 243159001930 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 243159001931 putative feedback inhibition sensing region; other site 243159001932 putative nucleotide binding site [chemical binding]; other site 243159001933 putative substrate binding site [chemical binding]; other site 243159001934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159001935 Coenzyme A binding pocket [chemical binding]; other site 243159001936 BolA-like protein; Region: BolA; pfam01722 243159001937 YciI-like protein; Reviewed; Region: PRK11370 243159001938 intracellular septation protein A; Reviewed; Region: PRK00259 243159001939 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 243159001940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159001941 Walker A motif; other site 243159001942 ATP binding site [chemical binding]; other site 243159001943 Walker B motif; other site 243159001944 arginine finger; other site 243159001945 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 243159001946 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 243159001947 active site 243159001948 dimerization interface [polypeptide binding]; other site 243159001949 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 243159001950 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243159001951 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 243159001952 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 243159001953 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 243159001954 trimer interface [polypeptide binding]; other site 243159001955 active site 243159001956 substrate binding site [chemical binding]; other site 243159001957 CoA binding site [chemical binding]; other site 243159001958 Transcriptional regulator; Region: Rrf2; cl17282 243159001959 Rrf2 family protein; Region: rrf2_super; TIGR00738 243159001960 cysteine desulfurase; Provisional; Region: PRK14012 243159001961 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 243159001962 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243159001963 catalytic residue [active] 243159001964 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 243159001965 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 243159001966 trimerization site [polypeptide binding]; other site 243159001967 active site 243159001968 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 243159001969 DnaJ domain; Region: DnaJ; pfam00226 243159001970 co-chaperone HscB; Provisional; Region: hscB; PRK03578 243159001971 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 243159001972 chaperone protein HscA; Provisional; Region: hscA; PRK05183 243159001973 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 243159001974 nucleotide binding site [chemical binding]; other site 243159001975 putative NEF/HSP70 interaction site [polypeptide binding]; other site 243159001976 SBD interface [polypeptide binding]; other site 243159001977 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 243159001978 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243159001979 catalytic loop [active] 243159001980 iron binding site [ion binding]; other site 243159001981 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 243159001982 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 243159001983 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 243159001984 Ligand Binding Site [chemical binding]; other site 243159001985 hypothetical protein; Provisional; Region: PRK10279 243159001986 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 243159001987 active site 243159001988 nucleophile elbow; other site 243159001989 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 243159001990 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243159001991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159001992 ATP binding site [chemical binding]; other site 243159001993 putative Mg++ binding site [ion binding]; other site 243159001994 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 243159001995 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 243159001996 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243159001997 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243159001998 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 243159001999 Fic/DOC family; Region: Fic; pfam02661 243159002000 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243159002001 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243159002002 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243159002003 SIR2-like domain; Region: SIR2_2; pfam13289 243159002004 Integrase core domain; Region: rve_3; pfam13683 243159002005 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 243159002006 alkylmercury lyase; Provisional; Region: PRK13239 243159002007 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 243159002008 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 243159002009 putative molybdopterin cofactor binding site [chemical binding]; other site 243159002010 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 243159002011 putative molybdopterin cofactor binding site; other site 243159002012 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 243159002013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159002014 Walker A motif; other site 243159002015 ATP binding site [chemical binding]; other site 243159002016 Walker B motif; other site 243159002017 arginine finger; other site 243159002018 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243159002019 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 243159002020 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 243159002021 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 243159002022 substrate binding site [chemical binding]; other site 243159002023 catalytic Zn binding site [ion binding]; other site 243159002024 NAD binding site [chemical binding]; other site 243159002025 structural Zn binding site [ion binding]; other site 243159002026 dimer interface [polypeptide binding]; other site 243159002027 S-formylglutathione hydrolase; Region: PLN02442 243159002028 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 243159002029 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 243159002030 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159002031 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 243159002032 substrate binding site [chemical binding]; other site 243159002033 dimerization interface [polypeptide binding]; other site 243159002034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159002035 active site 243159002036 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243159002037 phosphorylation site [posttranslational modification] 243159002038 intermolecular recognition site; other site 243159002039 dimerization interface [polypeptide binding]; other site 243159002040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159002041 Walker A motif; other site 243159002042 ATP binding site [chemical binding]; other site 243159002043 Walker B motif; other site 243159002044 arginine finger; other site 243159002045 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243159002046 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243159002047 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 243159002048 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 243159002049 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 243159002050 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 243159002051 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 243159002052 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 243159002053 nickel binding site [ion binding]; other site 243159002054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 243159002055 TPR motif; other site 243159002056 binding surface 243159002057 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 243159002058 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243159002059 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243159002060 iron-sulfur cluster [ion binding]; other site 243159002061 [2Fe-2S] cluster binding site [ion binding]; other site 243159002062 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 243159002063 Acylphosphatase; Region: Acylphosphatase; pfam00708 243159002064 HypF finger; Region: zf-HYPF; pfam07503 243159002065 HypF finger; Region: zf-HYPF; pfam07503 243159002066 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 243159002067 HupF/HypC family; Region: HupF_HypC; pfam01455 243159002068 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 243159002069 dimer interface [polypeptide binding]; other site 243159002070 active site 243159002071 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 243159002072 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 243159002073 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 243159002074 dimerization interface [polypeptide binding]; other site 243159002075 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 243159002076 ATP binding site [chemical binding]; other site 243159002077 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 243159002078 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 243159002079 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243159002080 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243159002081 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 243159002082 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 243159002083 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 243159002084 heme-binding site [chemical binding]; other site 243159002085 threonine dehydratase; Reviewed; Region: PRK09224 243159002086 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 243159002087 tetramer interface [polypeptide binding]; other site 243159002088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159002089 catalytic residue [active] 243159002090 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 243159002091 putative Ile/Val binding site [chemical binding]; other site 243159002092 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 243159002093 putative Ile/Val binding site [chemical binding]; other site 243159002094 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 243159002095 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 243159002096 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 243159002097 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243159002098 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243159002099 putative acyl-acceptor binding pocket; other site 243159002100 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 243159002101 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 243159002102 substrate binding site [chemical binding]; other site 243159002103 active site 243159002104 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 243159002105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243159002106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243159002107 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 243159002108 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 243159002109 active site 243159002110 dimer interface [polypeptide binding]; other site 243159002111 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 243159002112 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 243159002113 active site 243159002114 FMN binding site [chemical binding]; other site 243159002115 substrate binding site [chemical binding]; other site 243159002116 3Fe-4S cluster binding site [ion binding]; other site 243159002117 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 243159002118 domain interface; other site 243159002119 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 243159002120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243159002121 Zn2+ binding site [ion binding]; other site 243159002122 Mg2+ binding site [ion binding]; other site 243159002123 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 243159002124 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 243159002125 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 243159002126 active site 243159002127 dimer interface [polypeptide binding]; other site 243159002128 metal binding site [ion binding]; metal-binding site 243159002129 shikimate kinase; Reviewed; Region: aroK; PRK00131 243159002130 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 243159002131 ADP binding site [chemical binding]; other site 243159002132 magnesium binding site [ion binding]; other site 243159002133 putative shikimate binding site; other site 243159002134 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 243159002135 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243159002136 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243159002137 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 243159002138 Pilus assembly protein, PilP; Region: PilP; pfam04351 243159002139 Pilus assembly protein, PilO; Region: PilO; pfam04350 243159002140 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 243159002141 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 243159002142 Competence protein A; Region: Competence_A; pfam11104 243159002143 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243159002144 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 243159002145 nucleoside/Zn binding site; other site 243159002146 dimer interface [polypeptide binding]; other site 243159002147 catalytic motif [active] 243159002148 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 243159002149 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 243159002150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159002151 Walker A/P-loop; other site 243159002152 ATP binding site [chemical binding]; other site 243159002153 Q-loop/lid; other site 243159002154 ABC transporter signature motif; other site 243159002155 Walker B; other site 243159002156 D-loop; other site 243159002157 H-loop/switch region; other site 243159002158 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 243159002159 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243159002160 PYR/PP interface [polypeptide binding]; other site 243159002161 dimer interface [polypeptide binding]; other site 243159002162 TPP binding site [chemical binding]; other site 243159002163 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243159002164 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 243159002165 TPP-binding site [chemical binding]; other site 243159002166 dimer interface [polypeptide binding]; other site 243159002167 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 243159002168 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 243159002169 putative valine binding site [chemical binding]; other site 243159002170 dimer interface [polypeptide binding]; other site 243159002171 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 243159002172 ketol-acid reductoisomerase; Provisional; Region: PRK05479 243159002173 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 243159002174 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 243159002175 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 243159002176 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 243159002177 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 243159002178 pyruvate kinase; Provisional; Region: PRK14725 243159002179 active site 243159002180 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243159002181 Ligand Binding Site [chemical binding]; other site 243159002182 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 243159002183 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243159002184 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243159002185 Walker A/P-loop; other site 243159002186 ATP binding site [chemical binding]; other site 243159002187 Q-loop/lid; other site 243159002188 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 243159002189 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243159002190 ABC transporter signature motif; other site 243159002191 Walker B; other site 243159002192 D-loop; other site 243159002193 H-loop/switch region; other site 243159002194 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 243159002195 heme-binding site [chemical binding]; other site 243159002196 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 243159002197 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 243159002198 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 243159002199 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 243159002200 nucleotide binding pocket [chemical binding]; other site 243159002201 K-X-D-G motif; other site 243159002202 catalytic site [active] 243159002203 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 243159002204 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 243159002205 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 243159002206 Dimer interface [polypeptide binding]; other site 243159002207 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 243159002208 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243159002209 gamma subunit interface [polypeptide binding]; other site 243159002210 epsilon subunit interface [polypeptide binding]; other site 243159002211 LBP interface [polypeptide binding]; other site 243159002212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159002213 S-adenosylmethionine binding site [chemical binding]; other site 243159002214 Protein of unknown function DUF45; Region: DUF45; pfam01863 243159002215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159002216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243159002217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243159002218 dimerization interface [polypeptide binding]; other site 243159002219 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243159002220 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243159002221 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243159002222 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243159002223 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243159002224 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243159002225 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 243159002226 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 243159002227 guanine deaminase; Provisional; Region: PRK09228 243159002228 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243159002229 active site 243159002230 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 243159002231 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 243159002232 active site 243159002233 purine riboside binding site [chemical binding]; other site 243159002234 Purine nucleoside permease (NUP); Region: NUP; cl17832 243159002235 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 243159002236 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 243159002237 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 243159002238 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 243159002239 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 243159002240 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 243159002241 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 243159002242 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 243159002243 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; cl17559 243159002244 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 243159002245 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 243159002246 XdhC Rossmann domain; Region: XdhC_C; pfam13478 243159002247 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 243159002248 amidase; Provisional; Region: PRK09201 243159002249 Amidase; Region: Amidase; cl11426 243159002250 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 243159002251 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 243159002252 active site 243159002253 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 243159002254 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 243159002255 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 243159002256 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 243159002257 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 243159002258 NodB motif; other site 243159002259 active site 243159002260 catalytic site [active] 243159002261 metal binding site [ion binding]; metal-binding site 243159002262 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 243159002263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243159002264 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 243159002265 homotrimer interaction site [polypeptide binding]; other site 243159002266 putative active site [active] 243159002267 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243159002268 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243159002269 putative acyl-acceptor binding pocket; other site 243159002270 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243159002271 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 243159002272 Ligand binding site; other site 243159002273 Putative Catalytic site; other site 243159002274 DXD motif; other site 243159002275 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 243159002276 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 243159002277 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243159002278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243159002279 NAD(P) binding site [chemical binding]; other site 243159002280 active site 243159002281 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243159002282 active site 2 [active] 243159002283 active site 1 [active] 243159002284 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 243159002285 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 243159002286 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243159002287 dimer interface [polypeptide binding]; other site 243159002288 active site 243159002289 Phosphopantetheine attachment site; Region: PP-binding; cl09936 243159002290 Predicted exporter [General function prediction only]; Region: COG4258 243159002291 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 243159002292 putative acyl-acceptor binding pocket; other site 243159002293 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243159002294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243159002295 AMP binding site [chemical binding]; other site 243159002296 active site 243159002297 acyl-activating enzyme (AAE) consensus motif; other site 243159002298 CoA binding site [chemical binding]; other site 243159002299 Predicted membrane protein [Function unknown]; Region: COG4648 243159002300 GH3 auxin-responsive promoter; Region: GH3; pfam03321 243159002301 Penicillin amidase; Region: Penicil_amidase; pfam01804 243159002302 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 243159002303 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 243159002304 active site 243159002305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243159002306 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 243159002307 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 243159002308 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 243159002309 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 243159002310 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 243159002311 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243159002312 catalytic loop [active] 243159002313 iron binding site [ion binding]; other site 243159002314 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 243159002315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159002316 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243159002317 putative substrate translocation pore; other site 243159002318 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 243159002319 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 243159002320 Cl- selectivity filter; other site 243159002321 Cl- binding residues [ion binding]; other site 243159002322 pore gating glutamate residue; other site 243159002323 dimer interface [polypeptide binding]; other site 243159002324 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 243159002325 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 243159002326 Cl- selectivity filter; other site 243159002327 Cl- binding residues [ion binding]; other site 243159002328 pore gating glutamate residue; other site 243159002329 dimer interface [polypeptide binding]; other site 243159002330 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 243159002331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243159002332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159002333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243159002334 dimerization interface [polypeptide binding]; other site 243159002335 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 243159002336 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 243159002337 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 243159002338 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243159002339 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243159002340 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243159002341 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243159002342 active site 243159002343 metal binding site [ion binding]; metal-binding site 243159002344 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243159002345 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 243159002346 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 243159002347 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 243159002348 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 243159002349 Virulence protein [General function prediction only]; Region: COG3943 243159002350 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 243159002351 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243159002352 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243159002353 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243159002354 Integrase core domain; Region: rve; pfam00665 243159002355 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 243159002356 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 243159002357 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 243159002358 Int/Topo IB signature motif; other site 243159002359 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243159002360 integron integrase; Region: integrase_gron; TIGR02249 243159002361 active site 243159002362 DNA binding site [nucleotide binding] 243159002363 Int/Topo IB signature motif; other site 243159002364 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 243159002365 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243159002366 active site 243159002367 DNA binding site [nucleotide binding] 243159002368 Int/Topo IB signature motif; other site 243159002369 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 243159002370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159002371 Walker A motif; other site 243159002372 ATP binding site [chemical binding]; other site 243159002373 Walker B motif; other site 243159002374 arginine finger; other site 243159002375 AAA domain; Region: AAA_21; pfam13304 243159002376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159002377 ABC transporter signature motif; other site 243159002378 Walker B; other site 243159002379 D-loop; other site 243159002380 H-loop/switch region; other site 243159002381 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 243159002382 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 243159002383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159002384 ATP binding site [chemical binding]; other site 243159002385 putative Mg++ binding site [ion binding]; other site 243159002386 Protein of unknown function DUF45; Region: DUF45; cl00636 243159002387 excinuclease ABC subunit B; Provisional; Region: PRK05298 243159002388 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 243159002389 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159002390 ATP-binding site [chemical binding]; other site 243159002391 ATP binding site [chemical binding]; other site 243159002392 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243159002393 nucleotide binding region [chemical binding]; other site 243159002394 ATP-binding site [chemical binding]; other site 243159002395 Ultra-violet resistance protein B; Region: UvrB; pfam12344 243159002396 UvrB/uvrC motif; Region: UVR; pfam02151 243159002397 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 243159002398 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 243159002399 putative NAD(P) binding site [chemical binding]; other site 243159002400 putative substrate binding site [chemical binding]; other site 243159002401 catalytic Zn binding site [ion binding]; other site 243159002402 structural Zn binding site [ion binding]; other site 243159002403 dimer interface [polypeptide binding]; other site 243159002404 CTP synthetase; Validated; Region: pyrG; PRK05380 243159002405 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 243159002406 Catalytic site [active] 243159002407 active site 243159002408 UTP binding site [chemical binding]; other site 243159002409 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 243159002410 active site 243159002411 putative oxyanion hole; other site 243159002412 catalytic triad [active] 243159002413 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 243159002414 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 243159002415 enolase; Provisional; Region: eno; PRK00077 243159002416 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 243159002417 dimer interface [polypeptide binding]; other site 243159002418 metal binding site [ion binding]; metal-binding site 243159002419 substrate binding pocket [chemical binding]; other site 243159002420 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 243159002421 Septum formation initiator; Region: DivIC; cl17659 243159002422 translation elongation factor P; Region: efp; TIGR00038 243159002423 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 243159002424 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 243159002425 RNA binding site [nucleotide binding]; other site 243159002426 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 243159002427 RNA binding site [nucleotide binding]; other site 243159002428 Protein of unknown function (DUF971); Region: DUF971; pfam06155 243159002429 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 243159002430 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 243159002431 GIY-YIG motif/motif A; other site 243159002432 active site 243159002433 catalytic site [active] 243159002434 putative DNA binding site [nucleotide binding]; other site 243159002435 metal binding site [ion binding]; metal-binding site 243159002436 UvrB/uvrC motif; Region: UVR; pfam02151 243159002437 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 243159002438 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 243159002439 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243159002440 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243159002441 ligand binding site [chemical binding]; other site 243159002442 flexible hinge region; other site 243159002443 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 243159002444 putative switch regulator; other site 243159002445 non-specific DNA interactions [nucleotide binding]; other site 243159002446 DNA binding site [nucleotide binding] 243159002447 sequence specific DNA binding site [nucleotide binding]; other site 243159002448 putative cAMP binding site [chemical binding]; other site 243159002449 Protein of unknown function, DUF488; Region: DUF488; cl01246 243159002450 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 243159002451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243159002452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243159002453 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 243159002454 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243159002455 catalytic loop [active] 243159002456 iron binding site [ion binding]; other site 243159002457 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 243159002458 FAD binding pocket [chemical binding]; other site 243159002459 FAD binding motif [chemical binding]; other site 243159002460 phosphate binding motif [ion binding]; other site 243159002461 beta-alpha-beta structure motif; other site 243159002462 NAD binding pocket [chemical binding]; other site 243159002463 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 243159002464 heme-binding site [chemical binding]; other site 243159002465 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 243159002466 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 243159002467 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159002468 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243159002469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159002470 putative substrate translocation pore; other site 243159002471 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243159002472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159002473 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243159002474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159002475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243159002476 dimerization interface [polypeptide binding]; other site 243159002477 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 243159002478 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 243159002479 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 243159002480 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 243159002481 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243159002482 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243159002483 putative dimer interface [polypeptide binding]; other site 243159002484 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 243159002485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159002486 Walker A motif; other site 243159002487 ATP binding site [chemical binding]; other site 243159002488 Walker B motif; other site 243159002489 arginine finger; other site 243159002490 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243159002491 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243159002492 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 243159002493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159002494 Coenzyme A binding pocket [chemical binding]; other site 243159002495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159002496 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 243159002497 substrate binding pocket [chemical binding]; other site 243159002498 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 243159002499 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 243159002500 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 243159002501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243159002502 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 243159002503 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 243159002504 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 243159002505 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 243159002506 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 243159002507 putative RNA binding site [nucleotide binding]; other site 243159002508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159002509 S-adenosylmethionine binding site [chemical binding]; other site 243159002510 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 243159002511 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 243159002512 DNA gyrase subunit A; Validated; Region: PRK05560 243159002513 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 243159002514 CAP-like domain; other site 243159002515 active site 243159002516 primary dimer interface [polypeptide binding]; other site 243159002517 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243159002518 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243159002519 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243159002520 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243159002521 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243159002522 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243159002523 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 243159002524 homodimer interface [polypeptide binding]; other site 243159002525 substrate-cofactor binding pocket; other site 243159002526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159002527 catalytic residue [active] 243159002528 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 243159002529 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 243159002530 ligand binding site [chemical binding]; other site 243159002531 NAD binding site [chemical binding]; other site 243159002532 dimerization interface [polypeptide binding]; other site 243159002533 catalytic site [active] 243159002534 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 243159002535 putative L-serine binding site [chemical binding]; other site 243159002536 Chorismate mutase type II; Region: CM_2; cl00693 243159002537 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 243159002538 Prephenate dehydratase; Region: PDT; pfam00800 243159002539 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 243159002540 putative L-Phe binding site [chemical binding]; other site 243159002541 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 243159002542 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243159002543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159002544 homodimer interface [polypeptide binding]; other site 243159002545 catalytic residue [active] 243159002546 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 243159002547 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 243159002548 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 243159002549 prephenate dehydrogenase; Validated; Region: PRK08507 243159002550 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 243159002551 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 243159002552 hinge; other site 243159002553 active site 243159002554 cytidylate kinase; Provisional; Region: cmk; PRK00023 243159002555 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 243159002556 CMP-binding site; other site 243159002557 The sites determining sugar specificity; other site 243159002558 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 243159002559 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 243159002560 RNA binding site [nucleotide binding]; other site 243159002561 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 243159002562 RNA binding site [nucleotide binding]; other site 243159002563 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 243159002564 RNA binding site [nucleotide binding]; other site 243159002565 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 243159002566 RNA binding site [nucleotide binding]; other site 243159002567 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243159002568 RNA binding site [nucleotide binding]; other site 243159002569 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243159002570 RNA binding site [nucleotide binding]; other site 243159002571 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243159002572 IHF - DNA interface [nucleotide binding]; other site 243159002573 IHF dimer interface [polypeptide binding]; other site 243159002574 tetratricopeptide repeat protein; Provisional; Region: PRK11788 243159002575 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243159002576 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 243159002577 active site 243159002578 dimer interface [polypeptide binding]; other site 243159002579 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243159002580 active site 243159002581 trigger factor; Provisional; Region: tig; PRK01490 243159002582 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243159002583 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 243159002584 Clp protease; Region: CLP_protease; pfam00574 243159002585 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 243159002586 oligomer interface [polypeptide binding]; other site 243159002587 active site residues [active] 243159002588 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 243159002589 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 243159002590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159002591 Walker A motif; other site 243159002592 ATP binding site [chemical binding]; other site 243159002593 Walker B motif; other site 243159002594 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243159002595 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 243159002596 Found in ATP-dependent protease La (LON); Region: LON; smart00464 243159002597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159002598 Walker A motif; other site 243159002599 ATP binding site [chemical binding]; other site 243159002600 Walker B motif; other site 243159002601 arginine finger; other site 243159002602 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243159002603 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243159002604 IHF dimer interface [polypeptide binding]; other site 243159002605 IHF - DNA interface [nucleotide binding]; other site 243159002606 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 243159002607 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 243159002608 active site 243159002609 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 243159002610 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 243159002611 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 243159002612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159002613 putative substrate translocation pore; other site 243159002614 putative lysogenization regulator; Reviewed; Region: PRK00218 243159002615 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243159002616 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 243159002617 metal binding triad; other site 243159002618 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243159002619 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243159002620 Zn2+ binding site [ion binding]; other site 243159002621 Mg2+ binding site [ion binding]; other site 243159002622 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 243159002623 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 243159002624 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 243159002625 active site 243159002626 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 243159002627 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 243159002628 active site 243159002629 nucleotide binding site [chemical binding]; other site 243159002630 HIGH motif; other site 243159002631 KMSKS motif; other site 243159002632 thiamine monophosphate kinase; Provisional; Region: PRK05731 243159002633 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 243159002634 ATP binding site [chemical binding]; other site 243159002635 dimerization interface [polypeptide binding]; other site 243159002636 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 243159002637 tetramer interfaces [polypeptide binding]; other site 243159002638 binuclear metal-binding site [ion binding]; other site 243159002639 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 243159002640 recombinase A; Provisional; Region: recA; PRK09354 243159002641 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 243159002642 hexamer interface [polypeptide binding]; other site 243159002643 Walker A motif; other site 243159002644 ATP binding site [chemical binding]; other site 243159002645 Walker B motif; other site 243159002646 RecX family; Region: RecX; pfam02631 243159002647 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 243159002648 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 243159002649 motif 1; other site 243159002650 active site 243159002651 motif 2; other site 243159002652 motif 3; other site 243159002653 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 243159002654 DHHA1 domain; Region: DHHA1; pfam02272 243159002655 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 243159002656 nickel binding site [ion binding]; other site 243159002657 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 243159002658 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 243159002659 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 243159002660 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 243159002661 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 243159002662 FAD binding pocket [chemical binding]; other site 243159002663 FAD binding motif [chemical binding]; other site 243159002664 phosphate binding motif [ion binding]; other site 243159002665 beta-alpha-beta structure motif; other site 243159002666 NAD binding pocket [chemical binding]; other site 243159002667 Iron coordination center [ion binding]; other site 243159002668 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 243159002669 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 243159002670 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243159002671 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243159002672 catalytic residue [active] 243159002673 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 243159002674 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159002675 ATP binding site [chemical binding]; other site 243159002676 putative Mg++ binding site [ion binding]; other site 243159002677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243159002678 nucleotide binding region [chemical binding]; other site 243159002679 ATP-binding site [chemical binding]; other site 243159002680 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 243159002681 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 243159002682 active site 243159002683 substrate binding site [chemical binding]; other site 243159002684 metal binding site [ion binding]; metal-binding site 243159002685 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 243159002686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159002687 Walker A/P-loop; other site 243159002688 ATP binding site [chemical binding]; other site 243159002689 Q-loop/lid; other site 243159002690 ABC transporter signature motif; other site 243159002691 Walker B; other site 243159002692 D-loop; other site 243159002693 H-loop/switch region; other site 243159002694 ABC transporter; Region: ABC_tran_2; pfam12848 243159002695 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243159002696 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 243159002697 ThiC-associated domain; Region: ThiC-associated; pfam13667 243159002698 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 243159002699 Predicted integral membrane protein [Function unknown]; Region: COG5615 243159002700 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 243159002701 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243159002702 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243159002703 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 243159002704 NAD(P) binding site [chemical binding]; other site 243159002705 catalytic residues [active] 243159002706 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 243159002707 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 243159002708 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 243159002709 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 243159002710 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243159002711 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243159002712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159002713 Walker A motif; other site 243159002714 ATP binding site [chemical binding]; other site 243159002715 Walker B motif; other site 243159002716 arginine finger; other site 243159002717 HTH domain; Region: HTH_11; pfam08279 243159002718 putative hydrolase; Provisional; Region: PRK11460 243159002719 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 243159002720 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 243159002721 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243159002722 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243159002723 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 243159002724 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 243159002725 asparaginyl-tRNA synthetase; Region: PLN02221 243159002726 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 243159002727 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 243159002728 Ligand binding site; other site 243159002729 DXD motif; other site 243159002730 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 243159002731 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 243159002732 putative NAD(P) binding site [chemical binding]; other site 243159002733 active site 243159002734 V4R domain; Region: V4R; cl15268 243159002735 von Willebrand factor type A domain; Region: VWA_2; pfam13519 243159002736 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243159002737 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243159002738 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 243159002739 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 243159002740 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 243159002741 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243159002742 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243159002743 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 243159002744 putative inner membrane peptidase; Provisional; Region: PRK11778 243159002745 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 243159002746 tandem repeat interface [polypeptide binding]; other site 243159002747 oligomer interface [polypeptide binding]; other site 243159002748 active site residues [active] 243159002749 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 243159002750 MoaE interaction surface [polypeptide binding]; other site 243159002751 MoeB interaction surface [polypeptide binding]; other site 243159002752 thiocarboxylated glycine; other site 243159002753 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 243159002754 MoaE homodimer interface [polypeptide binding]; other site 243159002755 MoaD interaction [polypeptide binding]; other site 243159002756 active site residues [active] 243159002757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 243159002758 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 243159002759 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 243159002760 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 243159002761 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 243159002762 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 243159002763 lipoyl attachment site [posttranslational modification]; other site 243159002764 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 243159002765 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243159002766 catalytic residue [active] 243159002767 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 243159002768 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243159002769 catalytic residue [active] 243159002770 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 243159002771 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243159002772 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 243159002773 Walker A/P-loop; other site 243159002774 ATP binding site [chemical binding]; other site 243159002775 Q-loop/lid; other site 243159002776 ABC transporter signature motif; other site 243159002777 Walker B; other site 243159002778 D-loop; other site 243159002779 H-loop/switch region; other site 243159002780 Ferredoxin [Energy production and conversion]; Region: COG1146 243159002781 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 243159002782 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 243159002783 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 243159002784 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 243159002785 dimer interface [polypeptide binding]; other site 243159002786 decamer (pentamer of dimers) interface [polypeptide binding]; other site 243159002787 catalytic triad [active] 243159002788 peroxidatic and resolving cysteines [active] 243159002789 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 243159002790 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 243159002791 active site 243159002792 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 243159002793 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 243159002794 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 243159002795 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243159002796 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 243159002797 active site 243159002798 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 243159002799 putative hydrolase; Provisional; Region: PRK02113 243159002800 integrase; Provisional; Region: int; PHA02601 243159002801 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 243159002802 Int/Topo IB signature motif; other site 243159002803 Helix-turn-helix domain; Region: HTH_17; pfam12728 243159002804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243159002805 non-specific DNA binding site [nucleotide binding]; other site 243159002806 salt bridge; other site 243159002807 sequence-specific DNA binding site [nucleotide binding]; other site 243159002808 Predicted transcriptional regulator [Transcription]; Region: COG2932 243159002809 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 243159002810 Catalytic site [active] 243159002811 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 243159002812 Prophage antirepressor [Transcription]; Region: COG3617 243159002813 BRO family, N-terminal domain; Region: Bro-N; smart01040 243159002814 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243159002815 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 243159002816 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243159002817 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 243159002818 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 243159002819 active site 243159002820 interdomain interaction site; other site 243159002821 putative metal-binding site [ion binding]; other site 243159002822 nucleotide binding site [chemical binding]; other site 243159002823 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 243159002824 domain I; other site 243159002825 DNA binding groove [nucleotide binding] 243159002826 phosphate binding site [ion binding]; other site 243159002827 domain II; other site 243159002828 domain III; other site 243159002829 nucleotide binding site [chemical binding]; other site 243159002830 catalytic site [active] 243159002831 domain IV; other site 243159002832 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 243159002833 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243159002834 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 243159002835 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 243159002836 active site 243159002837 nucleophile elbow; other site 243159002838 RRXRR protein; Region: RRXRR; pfam14239 243159002839 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 243159002840 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243159002841 active site 243159002842 Peptidase family M50; Region: Peptidase_M50; pfam02163 243159002843 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 243159002844 active site 243159002845 putative substrate binding region [chemical binding]; other site 243159002846 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 243159002847 PLD-like domain; Region: PLDc_2; pfam13091 243159002848 putative active site [active] 243159002849 catalytic site [active] 243159002850 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 243159002851 PLD-like domain; Region: PLDc_2; pfam13091 243159002852 putative active site [active] 243159002853 putative catalytic site [active] 243159002854 Protein of unknown function (DUF541); Region: SIMPL; cl01077 243159002855 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 243159002856 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 243159002857 catalytic residues [active] 243159002858 catalytic nucleophile [active] 243159002859 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 243159002860 SET domain; Region: SET; pfam00856 243159002861 CRISPR type AFERR-associated DEAD/DEAH-box helicase Csf4; Region: cas_csf4; TIGR03117 243159002862 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 243159002863 CRISPR/Cas system-associated protein Csf1; Region: Csf1_U; cd09705 243159002864 CRISPR type AFERR-associated protein Csf1; Region: cas_csf1; TIGR03114 243159002865 CRISPR/Cas system-associated RAMP superfamily protein Csf2; Region: Csf2_U; cd09706 243159002866 CRISPR/Cas system-associated RAMP superfamily protein Csf3; Region: Csf3_U; cd09707 243159002867 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cl09835 243159002868 CHC2 zinc finger; Region: zf-CHC2; cl17510 243159002869 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 243159002870 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 243159002871 DNA binding site [nucleotide binding] 243159002872 AAA domain; Region: AAA_30; pfam13604 243159002873 Family description; Region: UvrD_C_2; pfam13538 243159002874 putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183 243159002875 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243159002876 Active Sites [active] 243159002877 TPR repeat; Region: TPR_11; pfam13414 243159002878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159002879 binding surface 243159002880 TPR motif; other site 243159002881 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 243159002882 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 243159002883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 243159002884 Probable transposase; Region: OrfB_IS605; pfam01385 243159002885 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 243159002886 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243159002887 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243159002888 catalytic residue [active] 243159002889 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 243159002890 F plasmid transfer operon protein; Region: TraF; pfam13728 243159002891 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 243159002892 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 243159002893 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243159002894 IHF dimer interface [polypeptide binding]; other site 243159002895 IHF - DNA interface [nucleotide binding]; other site 243159002896 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 243159002897 RES domain; Region: RES; smart00953 243159002898 Prophage antirepressor [Transcription]; Region: COG3617 243159002899 BRO family, N-terminal domain; Region: Bro-N; smart01040 243159002900 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 243159002901 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 243159002902 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243159002903 TraL protein; Region: TraL; cl06278 243159002904 type IV conjugative transfer system protein TraE; Region: TraE_TIGR; TIGR02761 243159002905 TraK protein; Region: TraK; pfam06586 243159002906 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 243159002907 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 243159002908 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 243159002909 type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747 243159002910 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 243159002911 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243159002912 Type II/IV secretion system protein; Region: T2SE; pfam00437 243159002913 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243159002914 Walker A motif; other site 243159002915 ATP binding site [chemical binding]; other site 243159002916 Walker B motif; other site 243159002917 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 243159002918 catalytic residues [active] 243159002919 hinge region; other site 243159002920 alpha helical domain; other site 243159002921 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 243159002922 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 243159002923 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 243159002924 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 243159002925 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 243159002926 TraU protein; Region: TraU; pfam06834 243159002927 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876 243159002928 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 243159002929 PemK-like protein; Region: PemK; cl00995 243159002930 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 243159002931 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 243159002932 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 243159002933 catalytic residues [active] 243159002934 catalytic nucleophile [active] 243159002935 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 243159002936 Nuclease-related domain; Region: NERD; pfam08378 243159002937 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243159002938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243159002939 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243159002940 Peptidase family M48; Region: Peptidase_M48; cl12018 243159002941 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243159002942 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243159002943 active site 243159002944 metal binding site [ion binding]; metal-binding site 243159002945 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 243159002946 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 243159002947 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 243159002948 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 243159002949 catalytic triad [active] 243159002950 conserved cis-peptide bond; other site 243159002951 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243159002952 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 243159002953 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 243159002954 Family description; Region: UvrD_C_2; pfam13538 243159002955 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 243159002956 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243159002957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243159002958 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243159002959 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 243159002960 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243159002961 active site 243159002962 DNA binding site [nucleotide binding] 243159002963 Int/Topo IB signature motif; other site 243159002964 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 243159002965 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243159002966 active site 243159002967 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 243159002968 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 243159002969 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 243159002970 RNA/DNA hybrid binding site [nucleotide binding]; other site 243159002971 active site 243159002972 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 243159002973 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 243159002974 Integrase core domain; Region: rve; pfam00665 243159002975 AAA domain; Region: AAA_22; pfam13401 243159002976 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 243159002977 AAA ATPase domain; Region: AAA_16; pfam13191 243159002978 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 243159002979 Autotransporter beta-domain; Region: Autotransporter; pfam03797 243159002980 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 243159002981 Autotransporter beta-domain; Region: Autotransporter; smart00869 243159002982 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 243159002983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159002984 binding surface 243159002985 TPR motif; other site 243159002986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159002987 binding surface 243159002988 TPR motif; other site 243159002989 TPR repeat; Region: TPR_11; pfam13414 243159002990 TPR repeat; Region: TPR_11; pfam13414 243159002991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159002992 binding surface 243159002993 TPR motif; other site 243159002994 TPR repeat; Region: TPR_11; pfam13414 243159002995 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243159002996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159002997 binding surface 243159002998 TPR motif; other site 243159002999 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 243159003000 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243159003001 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243159003002 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 243159003003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 243159003004 Probable transposase; Region: OrfB_IS605; pfam01385 243159003005 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 243159003006 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 243159003007 Fe-S cluster binding site [ion binding]; other site 243159003008 active site 243159003009 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 243159003010 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 243159003011 DNA methylase; Region: N6_N4_Mtase; cl17433 243159003012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159003013 AAA domain; Region: AAA_23; pfam13476 243159003014 Walker A/P-loop; other site 243159003015 ATP binding site [chemical binding]; other site 243159003016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159003017 ABC transporter signature motif; other site 243159003018 Walker B; other site 243159003019 D-loop; other site 243159003020 H-loop/switch region; other site 243159003021 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 243159003022 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 243159003023 active site 243159003024 metal binding site [ion binding]; metal-binding site 243159003025 DNA binding site [nucleotide binding] 243159003026 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243159003027 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 243159003028 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 243159003029 nucleotide binding pocket [chemical binding]; other site 243159003030 K-X-D-G motif; other site 243159003031 catalytic site [active] 243159003032 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 243159003033 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 243159003034 Dimer interface [polypeptide binding]; other site 243159003035 BRCT sequence motif; other site 243159003036 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 243159003037 putative active site [active] 243159003038 AAA domain; Region: AAA_22; pfam13401 243159003039 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243159003040 IHF - DNA interface [nucleotide binding]; other site 243159003041 IHF dimer interface [polypeptide binding]; other site 243159003042 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 243159003043 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 243159003044 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 243159003045 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 243159003046 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 243159003047 domain I; other site 243159003048 phosphate binding site [ion binding]; other site 243159003049 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 243159003050 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 243159003051 dimer interface [polypeptide binding]; other site 243159003052 ssDNA binding site [nucleotide binding]; other site 243159003053 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243159003054 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243159003055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243159003056 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243159003057 ERF superfamily; Region: ERF; pfam04404 243159003058 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 243159003059 Methyltransferase domain; Region: Methyltransf_27; pfam13708 243159003060 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 243159003061 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243159003062 metal ion-dependent adhesion site (MIDAS); other site 243159003063 Response regulator receiver domain; Region: Response_reg; pfam00072 243159003064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159003065 active site 243159003066 phosphorylation site [posttranslational modification] 243159003067 intermolecular recognition site; other site 243159003068 dimerization interface [polypeptide binding]; other site 243159003069 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243159003070 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 243159003071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159003072 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 243159003073 substrate binding site [chemical binding]; other site 243159003074 dimerization interface [polypeptide binding]; other site 243159003075 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 243159003076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159003077 Walker A motif; other site 243159003078 ATP binding site [chemical binding]; other site 243159003079 Walker B motif; other site 243159003080 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243159003081 Active Sites [active] 243159003082 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 243159003083 DNA binding residues [nucleotide binding] 243159003084 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 243159003085 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 243159003086 catalytic residues [active] 243159003087 catalytic nucleophile [active] 243159003088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 243159003089 Uncharacterized conserved protein [Function unknown]; Region: COG0393 243159003090 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 243159003091 PRTRC system protein D; Region: PRTRC_D; TIGR03739 243159003092 Mg binding site [ion binding]; other site 243159003093 nucleotide binding site [chemical binding]; other site 243159003094 putative protofilament interface [polypeptide binding]; other site 243159003095 AntA/AntB antirepressor; Region: AntA; pfam08346 243159003096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 243159003097 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 243159003098 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243159003099 MULE transposase domain; Region: MULE; pfam10551 243159003100 ParB-like nuclease domain; Region: ParBc; cl02129 243159003101 Short C-terminal domain; Region: SHOCT; pfam09851 243159003102 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 243159003103 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 243159003104 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 243159003105 active site 243159003106 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243159003107 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 243159003108 tyrosine kinase; Provisional; Region: PRK11519 243159003109 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 243159003110 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243159003111 Magnesium ion binding site [ion binding]; other site 243159003112 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 243159003113 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 243159003114 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 243159003115 NAD binding site [chemical binding]; other site 243159003116 homodimer interface [polypeptide binding]; other site 243159003117 active site 243159003118 substrate binding site [chemical binding]; other site 243159003119 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 243159003120 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 243159003121 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 243159003122 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 243159003123 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 243159003124 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 243159003125 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243159003126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159003127 S-adenosylmethionine binding site [chemical binding]; other site 243159003128 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243159003129 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243159003130 active site 243159003131 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 243159003132 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243159003133 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159003134 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243159003135 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159003136 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 243159003137 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 243159003138 active site 243159003139 dimer interface [polypeptide binding]; other site 243159003140 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243159003141 Ligand Binding Site [chemical binding]; other site 243159003142 Molecular Tunnel; other site 243159003143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159003144 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243159003145 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243159003146 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159003147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159003148 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 243159003149 putative ADP-binding pocket [chemical binding]; other site 243159003150 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 243159003151 active site 243159003152 NTP binding site [chemical binding]; other site 243159003153 metal binding triad [ion binding]; metal-binding site 243159003154 antibiotic binding site [chemical binding]; other site 243159003155 HEPN domain; Region: HEPN; pfam05168 243159003156 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 243159003157 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 243159003158 oligomeric interface; other site 243159003159 putative active site [active] 243159003160 homodimer interface [polypeptide binding]; other site 243159003161 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 243159003162 active site 243159003163 NTP binding site [chemical binding]; other site 243159003164 metal binding triad [ion binding]; metal-binding site 243159003165 antibiotic binding site [chemical binding]; other site 243159003166 HEPN domain; Region: HEPN; pfam05168 243159003167 RRXRR protein; Region: RRXRR; pfam14239 243159003168 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243159003169 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 243159003170 active site 243159003171 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 243159003172 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 243159003173 Substrate binding site; other site 243159003174 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 243159003175 Protein of unknown function (DUF433); Region: DUF433; pfam04255 243159003176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 243159003177 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 243159003178 putative active site [active] 243159003179 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 243159003180 Bacterial sugar transferase; Region: Bac_transf; pfam02397 243159003181 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 243159003182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159003183 ATP binding site [chemical binding]; other site 243159003184 putative Mg++ binding site [ion binding]; other site 243159003185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243159003186 nucleotide binding region [chemical binding]; other site 243159003187 ATP-binding site [chemical binding]; other site 243159003188 Fic family protein [Function unknown]; Region: COG3177 243159003189 Fic/DOC family; Region: Fic; pfam02661 243159003190 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 243159003191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159003192 Walker A motif; other site 243159003193 ATP binding site [chemical binding]; other site 243159003194 Walker B motif; other site 243159003195 Helix-turn-helix domain; Region: HTH_28; pfam13518 243159003196 Winged helix-turn helix; Region: HTH_29; pfam13551 243159003197 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 243159003198 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 243159003199 catalytic residues [active] 243159003200 catalytic nucleophile [active] 243159003201 Recombinase; Region: Recombinase; pfam07508 243159003202 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 243159003203 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243159003204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243159003205 non-specific DNA binding site [nucleotide binding]; other site 243159003206 salt bridge; other site 243159003207 sequence-specific DNA binding site [nucleotide binding]; other site 243159003208 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 243159003209 T5orf172 domain; Region: T5orf172; pfam10544 243159003210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 243159003211 FIST N domain; Region: FIST; pfam08495 243159003212 FIST C domain; Region: FIST_C; pfam10442 243159003213 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 243159003214 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243159003215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159003216 Walker A/P-loop; other site 243159003217 ATP binding site [chemical binding]; other site 243159003218 Q-loop/lid; other site 243159003219 ABC transporter signature motif; other site 243159003220 Walker B; other site 243159003221 D-loop; other site 243159003222 H-loop/switch region; other site 243159003223 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 243159003224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159003225 Walker A/P-loop; other site 243159003226 ATP binding site [chemical binding]; other site 243159003227 Q-loop/lid; other site 243159003228 ABC transporter signature motif; other site 243159003229 Walker B; other site 243159003230 D-loop; other site 243159003231 H-loop/switch region; other site 243159003232 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 243159003233 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 243159003234 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 243159003235 L-aspartate oxidase; Provisional; Region: PRK09077 243159003236 L-aspartate oxidase; Provisional; Region: PRK06175 243159003237 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 243159003238 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 243159003239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243159003240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243159003241 DNA binding residues [nucleotide binding] 243159003242 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 243159003243 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243159003244 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243159003245 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243159003246 protein binding site [polypeptide binding]; other site 243159003247 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243159003248 protein binding site [polypeptide binding]; other site 243159003249 GTP-binding protein LepA; Provisional; Region: PRK05433 243159003250 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 243159003251 G1 box; other site 243159003252 putative GEF interaction site [polypeptide binding]; other site 243159003253 GTP/Mg2+ binding site [chemical binding]; other site 243159003254 Switch I region; other site 243159003255 G2 box; other site 243159003256 G3 box; other site 243159003257 Switch II region; other site 243159003258 G4 box; other site 243159003259 G5 box; other site 243159003260 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 243159003261 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 243159003262 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 243159003263 signal peptidase I; Provisional; Region: PRK10861 243159003264 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 243159003265 Catalytic site [active] 243159003266 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 243159003267 ribonuclease III; Reviewed; Region: rnc; PRK00102 243159003268 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 243159003269 dimerization interface [polypeptide binding]; other site 243159003270 active site 243159003271 metal binding site [ion binding]; metal-binding site 243159003272 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 243159003273 dsRNA binding site [nucleotide binding]; other site 243159003274 GTPase Era; Reviewed; Region: era; PRK00089 243159003275 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 243159003276 G1 box; other site 243159003277 GTP/Mg2+ binding site [chemical binding]; other site 243159003278 Switch I region; other site 243159003279 G2 box; other site 243159003280 Switch II region; other site 243159003281 G3 box; other site 243159003282 G4 box; other site 243159003283 G5 box; other site 243159003284 KH domain; Region: KH_2; pfam07650 243159003285 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 243159003286 Recombination protein O N terminal; Region: RecO_N; pfam11967 243159003287 Recombination protein O C terminal; Region: RecO_C; pfam02565 243159003288 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 243159003289 active site 243159003290 hydrophilic channel; other site 243159003291 dimerization interface [polypeptide binding]; other site 243159003292 catalytic residues [active] 243159003293 active site lid [active] 243159003294 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 243159003295 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 243159003296 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 243159003297 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 243159003298 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 243159003299 putative ribose interaction site [chemical binding]; other site 243159003300 putative ADP binding site [chemical binding]; other site 243159003301 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 243159003302 Ligand Binding Site [chemical binding]; other site 243159003303 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 243159003304 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 243159003305 dimerization interface [polypeptide binding]; other site 243159003306 domain crossover interface; other site 243159003307 redox-dependent activation switch; other site 243159003308 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 243159003309 putative regulator PrlF; Provisional; Region: PRK09974 243159003310 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 243159003311 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 243159003312 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243159003313 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243159003314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 243159003315 Helix-turn-helix domain; Region: HTH_17; pfam12728 243159003316 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243159003317 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 243159003318 putative active site [active] 243159003319 putative metal binding site [ion binding]; other site 243159003320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159003321 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 243159003322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159003323 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 243159003324 putative ADP-binding pocket [chemical binding]; other site 243159003325 Cytochrome c; Region: Cytochrom_C; cl11414 243159003326 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243159003327 Cytochrome c; Region: Cytochrom_C; cl11414 243159003328 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 243159003329 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 243159003330 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243159003331 DNA binding residues [nucleotide binding] 243159003332 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243159003333 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243159003334 ATP binding site [chemical binding]; other site 243159003335 Mg++ binding site [ion binding]; other site 243159003336 motif III; other site 243159003337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243159003338 nucleotide binding region [chemical binding]; other site 243159003339 ATP-binding site [chemical binding]; other site 243159003340 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 243159003341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159003342 active site 243159003343 phosphorylation site [posttranslational modification] 243159003344 intermolecular recognition site; other site 243159003345 dimerization interface [polypeptide binding]; other site 243159003346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243159003347 DNA binding site [nucleotide binding] 243159003348 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 243159003349 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243159003350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 243159003351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243159003352 dimer interface [polypeptide binding]; other site 243159003353 phosphorylation site [posttranslational modification] 243159003354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159003355 ATP binding site [chemical binding]; other site 243159003356 Mg2+ binding site [ion binding]; other site 243159003357 G-X-G motif; other site 243159003358 PBP superfamily domain; Region: PBP_like_2; cl17296 243159003359 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 243159003360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243159003361 dimer interface [polypeptide binding]; other site 243159003362 conserved gate region; other site 243159003363 putative PBP binding loops; other site 243159003364 ABC-ATPase subunit interface; other site 243159003365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243159003366 dimer interface [polypeptide binding]; other site 243159003367 conserved gate region; other site 243159003368 putative PBP binding loops; other site 243159003369 ABC-ATPase subunit interface; other site 243159003370 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 243159003371 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 243159003372 Walker A/P-loop; other site 243159003373 ATP binding site [chemical binding]; other site 243159003374 Q-loop/lid; other site 243159003375 ABC transporter signature motif; other site 243159003376 Walker B; other site 243159003377 D-loop; other site 243159003378 H-loop/switch region; other site 243159003379 transcriptional regulator PhoU; Provisional; Region: PRK11115 243159003380 PhoU domain; Region: PhoU; pfam01895 243159003381 PhoU domain; Region: PhoU; pfam01895 243159003382 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 243159003383 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 243159003384 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243159003385 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 243159003386 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 243159003387 rRNA interaction site [nucleotide binding]; other site 243159003388 S8 interaction site; other site 243159003389 putative laminin-1 binding site; other site 243159003390 elongation factor Ts; Provisional; Region: tsf; PRK09377 243159003391 UBA/TS-N domain; Region: UBA; pfam00627 243159003392 Elongation factor TS; Region: EF_TS; pfam00889 243159003393 Elongation factor TS; Region: EF_TS; pfam00889 243159003394 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 243159003395 putative nucleotide binding site [chemical binding]; other site 243159003396 uridine monophosphate binding site [chemical binding]; other site 243159003397 homohexameric interface [polypeptide binding]; other site 243159003398 ribosome recycling factor; Reviewed; Region: frr; PRK00083 243159003399 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 243159003400 hinge region; other site 243159003401 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 243159003402 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 243159003403 catalytic residue [active] 243159003404 putative FPP diphosphate binding site; other site 243159003405 putative FPP binding hydrophobic cleft; other site 243159003406 dimer interface [polypeptide binding]; other site 243159003407 putative IPP diphosphate binding site; other site 243159003408 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 243159003409 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 243159003410 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 243159003411 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 243159003412 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 243159003413 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 243159003414 zinc metallopeptidase RseP; Provisional; Region: PRK10779 243159003415 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 243159003416 active site 243159003417 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 243159003418 protein binding site [polypeptide binding]; other site 243159003419 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 243159003420 protein binding site [polypeptide binding]; other site 243159003421 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 243159003422 putative substrate binding region [chemical binding]; other site 243159003423 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 243159003424 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243159003425 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243159003426 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243159003427 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243159003428 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243159003429 Surface antigen; Region: Bac_surface_Ag; pfam01103 243159003430 periplasmic chaperone; Provisional; Region: PRK10780 243159003431 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 243159003432 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 243159003433 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 243159003434 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 243159003435 trimer interface [polypeptide binding]; other site 243159003436 active site 243159003437 UDP-GlcNAc binding site [chemical binding]; other site 243159003438 lipid binding site [chemical binding]; lipid-binding site 243159003439 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 243159003440 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 243159003441 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 243159003442 active site 243159003443 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243159003444 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243159003445 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 243159003446 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 243159003447 inhibitor-cofactor binding pocket; inhibition site 243159003448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159003449 catalytic residue [active] 243159003450 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 243159003451 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 243159003452 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 243159003453 RNA/DNA hybrid binding site [nucleotide binding]; other site 243159003454 active site 243159003455 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 243159003456 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 243159003457 putative active site [active] 243159003458 putative PHP Thumb interface [polypeptide binding]; other site 243159003459 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 243159003460 generic binding surface I; other site 243159003461 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 243159003462 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 243159003463 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 243159003464 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 243159003465 Ligand Binding Site [chemical binding]; other site 243159003466 TilS substrate binding domain; Region: TilS; pfam09179 243159003467 TilS substrate C-terminal domain; Region: TilS_C; smart00977 243159003468 dihydroorotase; Provisional; Region: PRK07575 243159003469 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243159003470 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 243159003471 active site 243159003472 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 243159003473 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 243159003474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243159003475 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 243159003476 metal binding site 2 [ion binding]; metal-binding site 243159003477 putative DNA binding helix; other site 243159003478 metal binding site 1 [ion binding]; metal-binding site 243159003479 dimer interface [polypeptide binding]; other site 243159003480 structural Zn2+ binding site [ion binding]; other site 243159003481 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 243159003482 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243159003483 catalytic triad [active] 243159003484 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 243159003485 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 243159003486 putative active site [active] 243159003487 PhoH-like protein; Region: PhoH; pfam02562 243159003488 arginine decarboxylase; Provisional; Region: PRK05354 243159003489 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 243159003490 dimer interface [polypeptide binding]; other site 243159003491 active site 243159003492 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243159003493 catalytic residues [active] 243159003494 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 243159003495 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 243159003496 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 243159003497 glutathionine S-transferase; Provisional; Region: PRK10542 243159003498 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 243159003499 C-terminal domain interface [polypeptide binding]; other site 243159003500 GSH binding site (G-site) [chemical binding]; other site 243159003501 dimer interface [polypeptide binding]; other site 243159003502 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 243159003503 dimer interface [polypeptide binding]; other site 243159003504 substrate binding pocket (H-site) [chemical binding]; other site 243159003505 N-terminal domain interface [polypeptide binding]; other site 243159003506 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 243159003507 oxidoreductase; Provisional; Region: PRK10015 243159003508 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 243159003509 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 243159003510 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 243159003511 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 243159003512 Ligand binding site [chemical binding]; other site 243159003513 Electron transfer flavoprotein domain; Region: ETF; pfam01012 243159003514 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 243159003515 heme-binding site [chemical binding]; other site 243159003516 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243159003517 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243159003518 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 243159003519 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243159003520 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243159003521 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243159003522 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 243159003523 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 243159003524 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 243159003525 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 243159003526 intersubunit interface [polypeptide binding]; other site 243159003527 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 243159003528 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 243159003529 ABC-ATPase subunit interface; other site 243159003530 dimer interface [polypeptide binding]; other site 243159003531 putative PBP binding regions; other site 243159003532 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 243159003533 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 243159003534 Walker A/P-loop; other site 243159003535 ATP binding site [chemical binding]; other site 243159003536 Q-loop/lid; other site 243159003537 ABC transporter signature motif; other site 243159003538 Walker B; other site 243159003539 D-loop; other site 243159003540 H-loop/switch region; other site 243159003541 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 243159003542 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243159003543 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 243159003544 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243159003545 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 243159003546 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 243159003547 putative metal binding site [ion binding]; other site 243159003548 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 243159003549 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 243159003550 ABC-ATPase subunit interface; other site 243159003551 dimer interface [polypeptide binding]; other site 243159003552 putative PBP binding regions; other site 243159003553 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 243159003554 Cation efflux family; Region: Cation_efflux; pfam01545 243159003555 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 243159003556 outer membrane porin, OprD family; Region: OprD; pfam03573 243159003557 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 243159003558 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 243159003559 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243159003560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159003561 Walker A motif; other site 243159003562 ATP binding site [chemical binding]; other site 243159003563 Walker B motif; other site 243159003564 arginine finger; other site 243159003565 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 243159003566 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 243159003567 active site residue [active] 243159003568 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243159003569 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243159003570 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 243159003571 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 243159003572 NADPH bind site [chemical binding]; other site 243159003573 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 243159003574 putative FMN binding site [chemical binding]; other site 243159003575 NADPH bind site [chemical binding]; other site 243159003576 Nitrogen fixation protein NifW; Region: NifW; pfam03206 243159003577 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 243159003578 serine O-acetyltransferase; Region: cysE; TIGR01172 243159003579 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 243159003580 trimer interface [polypeptide binding]; other site 243159003581 active site 243159003582 substrate binding site [chemical binding]; other site 243159003583 CoA binding site [chemical binding]; other site 243159003584 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 243159003585 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 243159003586 active site 243159003587 catalytic residues [active] 243159003588 metal binding site [ion binding]; metal-binding site 243159003589 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 243159003590 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 243159003591 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243159003592 catalytic residue [active] 243159003593 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 243159003594 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 243159003595 trimerization site [polypeptide binding]; other site 243159003596 active site 243159003597 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 243159003598 NifU-like domain; Region: NifU; pfam01106 243159003599 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 243159003600 NifQ; Region: NifQ; pfam04891 243159003601 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 243159003602 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 243159003603 Rop-like; Region: Rop-like; pfam05082 243159003604 probable nitrogen fixation protein; Region: TIGR02935 243159003605 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 243159003606 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 243159003607 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 243159003608 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 243159003609 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 243159003610 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243159003611 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 243159003612 catalytic loop [active] 243159003613 iron binding site [ion binding]; other site 243159003614 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 243159003615 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243159003616 catalytic loop [active] 243159003617 iron binding site [ion binding]; other site 243159003618 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 243159003619 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 243159003620 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 243159003621 MoFe protein beta/alpha subunit interactions; other site 243159003622 Beta subunit P cluster binding residues; other site 243159003623 MoFe protein beta subunit/Fe protein contacts; other site 243159003624 MoFe protein dimer/ dimer interactions; other site 243159003625 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 243159003626 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 243159003627 MoFe protein alpha/beta subunit interactions; other site 243159003628 Alpha subunit P cluster binding residues; other site 243159003629 FeMoco binding residues [chemical binding]; other site 243159003630 MoFe protein alpha subunit/Fe protein contacts; other site 243159003631 MoFe protein dimer/ dimer interactions; other site 243159003632 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 243159003633 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 243159003634 Nucleotide-binding sites [chemical binding]; other site 243159003635 Walker A motif; other site 243159003636 Switch I region of nucleotide binding site; other site 243159003637 Fe4S4 binding sites [ion binding]; other site 243159003638 Switch II region of nucleotide binding site; other site 243159003639 Response regulator receiver domain; Region: Response_reg; pfam00072 243159003640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159003641 active site 243159003642 phosphorylation site [posttranslational modification] 243159003643 dimerization interface [polypeptide binding]; other site 243159003644 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 243159003645 ADP-ribosyl-[dinitrogen reductase] hydrolase; Region: dinitro_DRAG; TIGR02662 243159003646 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 243159003647 ArsC family; Region: ArsC; pfam03960 243159003648 putative catalytic residues [active] 243159003649 Nif-specific regulatory protein; Region: nifA; TIGR01817 243159003650 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 243159003651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159003652 Walker A motif; other site 243159003653 ATP binding site [chemical binding]; other site 243159003654 Walker B motif; other site 243159003655 arginine finger; other site 243159003656 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243159003657 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 243159003658 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159003659 FeS/SAM binding site; other site 243159003660 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 243159003661 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243159003662 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 243159003663 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 243159003664 HEAT repeats; Region: HEAT_2; pfam13646 243159003665 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 243159003666 protein binding surface [polypeptide binding]; other site 243159003667 NifZ domain; Region: NifZ; pfam04319 243159003668 NifZ domain; Region: NifZ; pfam04319 243159003669 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 243159003670 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 243159003671 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243159003672 catalytic residue [active] 243159003673 NifT/FixU protein; Region: NifT; pfam06988 243159003674 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 243159003675 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 243159003676 inhibitor-cofactor binding pocket; inhibition site 243159003677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159003678 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243159003679 catalytic loop [active] 243159003680 iron binding site [ion binding]; other site 243159003681 SIR2-like domain; Region: SIR2_2; pfam13289 243159003682 molybdenum transport protein ModD; Provisional; Region: PRK06096 243159003683 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 243159003684 dimerization interface [polypeptide binding]; other site 243159003685 active site 243159003686 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 243159003687 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243159003688 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 243159003689 tetramerization interface [polypeptide binding]; other site 243159003690 NAD(P) binding site [chemical binding]; other site 243159003691 catalytic residues [active] 243159003692 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 243159003693 apolar tunnel; other site 243159003694 heme binding site [chemical binding]; other site 243159003695 dimerization interface [polypeptide binding]; other site 243159003696 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243159003697 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243159003698 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243159003699 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 243159003700 putative substrate binding site [chemical binding]; other site 243159003701 putative ATP binding site [chemical binding]; other site 243159003702 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 243159003703 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 243159003704 putative ADP-binding pocket [chemical binding]; other site 243159003705 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 243159003706 sucrose synthase; Region: sucr_synth; TIGR02470 243159003707 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 243159003708 putative ADP-binding pocket [chemical binding]; other site 243159003709 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 243159003710 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 243159003711 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 243159003712 DNA binding site [nucleotide binding] 243159003713 active site 243159003714 Domain of unknown function (DUF202); Region: DUF202; cl09954 243159003715 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 243159003716 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243159003717 active site 243159003718 DNA binding site [nucleotide binding] 243159003719 Int/Topo IB signature motif; other site 243159003720 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 243159003721 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 243159003722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243159003723 non-specific DNA binding site [nucleotide binding]; other site 243159003724 salt bridge; other site 243159003725 sequence-specific DNA binding site [nucleotide binding]; other site 243159003726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243159003727 sequence-specific DNA binding site [nucleotide binding]; other site 243159003728 salt bridge; other site 243159003729 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 243159003730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159003731 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243159003732 Walker A motif; other site 243159003733 ATP binding site [chemical binding]; other site 243159003734 Walker B motif; other site 243159003735 arginine finger; other site 243159003736 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 243159003737 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 243159003738 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 243159003739 dimer interface [polypeptide binding]; other site 243159003740 ssDNA binding site [nucleotide binding]; other site 243159003741 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243159003742 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 243159003743 AAA domain; Region: AAA_11; pfam13086 243159003744 Part of AAA domain; Region: AAA_19; pfam13245 243159003745 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 243159003746 AAA domain; Region: AAA_30; pfam13604 243159003747 AAA domain; Region: AAA_12; pfam13087 243159003748 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 243159003749 putative active site [active] 243159003750 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 243159003751 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 243159003752 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243159003753 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 243159003754 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 243159003755 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 243159003756 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243159003757 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243159003758 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243159003759 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243159003760 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 243159003761 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243159003762 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 243159003763 putative active site [active] 243159003764 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 243159003765 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243159003766 IHF dimer interface [polypeptide binding]; other site 243159003767 IHF - DNA interface [nucleotide binding]; other site 243159003768 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243159003769 IHF dimer interface [polypeptide binding]; other site 243159003770 IHF - DNA interface [nucleotide binding]; other site 243159003771 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 243159003772 IHF dimer interface [polypeptide binding]; other site 243159003773 IHF - DNA interface [nucleotide binding]; other site 243159003774 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 243159003775 Phosphate acyltransferases; Region: PlsC; smart00563 243159003776 putative acyl-acceptor binding pocket; other site 243159003777 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243159003778 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243159003779 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 243159003780 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243159003781 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243159003782 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243159003783 Walker A/P-loop; other site 243159003784 ATP binding site [chemical binding]; other site 243159003785 Q-loop/lid; other site 243159003786 ABC transporter signature motif; other site 243159003787 Walker B; other site 243159003788 D-loop; other site 243159003789 H-loop/switch region; other site 243159003790 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243159003791 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243159003792 Walker A/P-loop; other site 243159003793 ATP binding site [chemical binding]; other site 243159003794 Q-loop/lid; other site 243159003795 ABC transporter signature motif; other site 243159003796 Walker B; other site 243159003797 D-loop; other site 243159003798 H-loop/switch region; other site 243159003799 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 243159003800 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159003801 Transposase; Region: HTH_Tnp_1; cl17663 243159003802 DDE superfamily endonuclease; Region: DDE_5; cl17874 243159003803 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243159003804 PIN domain; Region: PIN_3; pfam13470 243159003805 DNA binding domain, excisionase family; Region: excise; TIGR01764 243159003806 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 243159003807 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 243159003808 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 243159003809 protein-export membrane protein SecD; Region: secD; TIGR01129 243159003810 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 243159003811 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 243159003812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243159003813 non-specific DNA binding site [nucleotide binding]; other site 243159003814 sequence-specific DNA binding site [nucleotide binding]; other site 243159003815 salt bridge; other site 243159003816 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 243159003817 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 243159003818 ATP binding site [chemical binding]; other site 243159003819 Walker A motif; other site 243159003820 hexamer interface [polypeptide binding]; other site 243159003821 Walker B motif; other site 243159003822 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 243159003823 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 243159003824 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 243159003825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159003826 Walker B; other site 243159003827 D-loop; other site 243159003828 H-loop/switch region; other site 243159003829 P-type conjugative transfer protein TrbJ; Region: TrbJ_Ti; TIGR02780 243159003830 P-type conjugative transfer protein TrbL; Region: TrbL_P; TIGR02783 243159003831 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 243159003832 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243159003833 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243159003834 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243159003835 protein binding site [polypeptide binding]; other site 243159003836 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243159003837 protein binding site [polypeptide binding]; other site 243159003838 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243159003839 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243159003840 putative dimer interface [polypeptide binding]; other site 243159003841 Integrase core domain; Region: rve; pfam00665 243159003842 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 243159003843 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243159003844 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 243159003845 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 243159003846 putative molybdopterin cofactor binding site [chemical binding]; other site 243159003847 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 243159003848 putative molybdopterin cofactor binding site; other site 243159003849 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 243159003850 Winged helix-turn helix; Region: HTH_33; pfam13592 243159003851 DDE superfamily endonuclease; Region: DDE_3; pfam13358 243159003852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 243159003853 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 243159003854 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243159003855 catalytic loop [active] 243159003856 iron binding site [ion binding]; other site 243159003857 Methane monooxygenase (MMO) reductase of methanotrophs catalyzes the NADH-dependent hydroxylation of methane to methanol. This multicomponent enzyme mediates electron transfer via a hydroxylase (MMOH), a coupling protein, and a reductase which is...; Region: MMO_FAD_NAD_binding; cd06210 243159003858 FAD binding pocket [chemical binding]; other site 243159003859 FAD binding motif [chemical binding]; other site 243159003860 phosphate binding motif [ion binding]; other site 243159003861 beta-alpha-beta structure motif; other site 243159003862 NAD binding pocket [chemical binding]; other site 243159003863 hybrid cluster protein; Provisional; Region: PRK05290 243159003864 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 243159003865 ACS interaction site; other site 243159003866 CODH interaction site; other site 243159003867 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 243159003868 hybrid metal cluster; other site 243159003869 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243159003870 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243159003871 ligand binding site [chemical binding]; other site 243159003872 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 243159003873 putative switch regulator; other site 243159003874 non-specific DNA interactions [nucleotide binding]; other site 243159003875 DNA binding site [nucleotide binding] 243159003876 sequence specific DNA binding site [nucleotide binding]; other site 243159003877 putative cAMP binding site [chemical binding]; other site 243159003878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 243159003879 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 243159003880 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 243159003881 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243159003882 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 243159003883 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 243159003884 Cysteine-rich domain; Region: CCG; pfam02754 243159003885 Cysteine-rich domain; Region: CCG; pfam02754 243159003886 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 243159003887 FAD binding domain; Region: FAD_binding_4; pfam01565 243159003888 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 243159003889 FAD binding domain; Region: FAD_binding_4; pfam01565 243159003890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 243159003891 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 243159003892 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 243159003893 TPP-binding site [chemical binding]; other site 243159003894 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 243159003895 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 243159003896 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243159003897 Bacterial transcriptional regulator; Region: IclR; pfam01614 243159003898 RNHCP domain; Region: RNHCP; pfam12647 243159003899 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 243159003900 active site 243159003901 substrate binding pocket [chemical binding]; other site 243159003902 dimer interface [polypeptide binding]; other site 243159003903 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 243159003904 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 243159003905 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 243159003906 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 243159003907 AAA domain; Region: AAA_26; pfam13500 243159003908 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 243159003909 active site 243159003910 intersubunit interface [polypeptide binding]; other site 243159003911 zinc binding site [ion binding]; other site 243159003912 Na+ binding site [ion binding]; other site 243159003913 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 243159003914 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 243159003915 metal ion-dependent adhesion site (MIDAS); other site 243159003916 MoxR-like ATPases [General function prediction only]; Region: COG0714 243159003917 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 243159003918 Walker A motif; other site 243159003919 ATP binding site [chemical binding]; other site 243159003920 Walker B motif; other site 243159003921 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 243159003922 ParA-like protein; Provisional; Region: PHA02518 243159003923 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243159003924 P-loop; other site 243159003925 Magnesium ion binding site [ion binding]; other site 243159003926 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 243159003927 DCoH dimer interaction site [polypeptide binding]; other site 243159003928 aromatic arch; other site 243159003929 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 243159003930 DCoH tetramer interaction site [polypeptide binding]; other site 243159003931 substrate binding site [chemical binding]; other site 243159003932 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 243159003933 Ferritin-like domain; Region: Ferritin; pfam00210 243159003934 dinuclear metal binding motif [ion binding]; other site 243159003935 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 243159003936 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 243159003937 Hexamer interface [polypeptide binding]; other site 243159003938 Hexagonal pore residue; other site 243159003939 Hexagonal pore; other site 243159003940 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 243159003941 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 243159003942 Hexamer interface [polypeptide binding]; other site 243159003943 Hexagonal pore residue; other site 243159003944 Hexagonal pore; other site 243159003945 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 243159003946 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 243159003947 Hexamer interface [polypeptide binding]; other site 243159003948 Hexagonal pore residue; other site 243159003949 Hexagonal pore; other site 243159003950 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 243159003951 Hexamer/Pentamer interface [polypeptide binding]; other site 243159003952 central pore; other site 243159003953 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 243159003954 Hexamer/Pentamer interface [polypeptide binding]; other site 243159003955 central pore; other site 243159003956 carboxysome shell carbonic anhydrase; Region: shell_carb_anhy; TIGR02701 243159003957 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 243159003958 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 243159003959 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 243159003960 multimerization interface [polypeptide binding]; other site 243159003961 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 243159003962 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 243159003963 dimer interface [polypeptide binding]; other site 243159003964 catalytic residue [active] 243159003965 metal binding site [ion binding]; metal-binding site 243159003966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243159003967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159003968 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 243159003969 putative dimerization interface [polypeptide binding]; other site 243159003970 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 243159003971 VirB8 protein; Region: VirB8; pfam04335 243159003972 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 243159003973 VirB7 interaction site; other site 243159003974 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 243159003975 VirB7 interaction site; other site 243159003976 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243159003977 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243159003978 catalytic residue [active] 243159003979 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 243159003980 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243159003981 Walker A motif; other site 243159003982 ATP binding site [chemical binding]; other site 243159003983 Walker B motif; other site 243159003984 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243159003985 GAF domain; Region: GAF; pfam01590 243159003986 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 243159003987 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243159003988 putative active site [active] 243159003989 heme pocket [chemical binding]; other site 243159003990 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243159003991 metal binding site [ion binding]; metal-binding site 243159003992 active site 243159003993 I-site; other site 243159003994 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243159003995 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 243159003996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 243159003997 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 243159003998 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 243159003999 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 243159004000 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 243159004001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 243159004002 PilZ domain; Region: PilZ; pfam07238 243159004003 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243159004004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243159004005 metal binding site [ion binding]; metal-binding site 243159004006 active site 243159004007 I-site; other site 243159004008 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243159004009 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 243159004010 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 243159004011 PLD-like domain; Region: PLDc_2; pfam13091 243159004012 putative active site [active] 243159004013 catalytic site [active] 243159004014 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128 243159004015 PLD-like domain; Region: PLDc_2; pfam13091 243159004016 putative active site [active] 243159004017 putative catalytic site [active] 243159004018 ParB-like nuclease domain; Region: ParBc; pfam02195 243159004019 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243159004020 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243159004021 P-loop; other site 243159004022 Magnesium ion binding site [ion binding]; other site 243159004023 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243159004024 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243159004025 active site 243159004026 catalytic tetrad [active] 243159004027 PAS fold; Region: PAS_4; pfam08448 243159004028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243159004029 putative active site [active] 243159004030 heme pocket [chemical binding]; other site 243159004031 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243159004032 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243159004033 metal binding site [ion binding]; metal-binding site 243159004034 active site 243159004035 I-site; other site 243159004036 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243159004037 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 243159004038 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 243159004039 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 243159004040 MarR family; Region: MarR_2; pfam12802 243159004041 conjugal transfer protein TraB; Provisional; Region: PRK13825 243159004042 dimer interface [polypeptide binding]; other site 243159004043 active site 243159004044 YcfA-like protein; Region: YcfA; cl00752 243159004045 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 243159004046 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 243159004047 DNA topoisomerase III; Provisional; Region: PRK07726 243159004048 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 243159004049 active site 243159004050 putative interdomain interaction site [polypeptide binding]; other site 243159004051 putative metal-binding site [ion binding]; other site 243159004052 putative nucleotide binding site [chemical binding]; other site 243159004053 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 243159004054 domain I; other site 243159004055 DNA binding groove [nucleotide binding] 243159004056 phosphate binding site [ion binding]; other site 243159004057 domain II; other site 243159004058 domain III; other site 243159004059 nucleotide binding site [chemical binding]; other site 243159004060 catalytic site [active] 243159004061 domain IV; other site 243159004062 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 243159004063 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 243159004064 putative active site [active] 243159004065 catalytic site [active] 243159004066 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 243159004067 putative active site [active] 243159004068 catalytic site [active] 243159004069 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 243159004070 GAF domain; Region: GAF; pfam01590 243159004071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159004072 Walker A motif; other site 243159004073 ATP binding site [chemical binding]; other site 243159004074 Walker B motif; other site 243159004075 arginine finger; other site 243159004076 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243159004077 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 243159004078 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243159004079 NAD(P) binding site [chemical binding]; other site 243159004080 catalytic residues [active] 243159004081 Protein of unknown function (DUF779); Region: DUF779; pfam05610 243159004082 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 243159004083 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 243159004084 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 243159004085 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 243159004086 Catalytic site [active] 243159004087 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 243159004088 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 243159004089 active site 243159004090 DNA binding site [nucleotide binding] 243159004091 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 243159004092 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 243159004093 potassium uptake protein; Region: kup; TIGR00794 243159004094 K+ potassium transporter; Region: K_trans; pfam02705 243159004095 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 243159004096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243159004097 sequence-specific DNA binding site [nucleotide binding]; other site 243159004098 salt bridge; other site 243159004099 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 243159004100 MutS domain I; Region: MutS_I; pfam01624 243159004101 MutS domain II; Region: MutS_II; pfam05188 243159004102 MutS domain III; Region: MutS_III; pfam05192 243159004103 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 243159004104 Walker A/P-loop; other site 243159004105 ATP binding site [chemical binding]; other site 243159004106 Q-loop/lid; other site 243159004107 ABC transporter signature motif; other site 243159004108 Walker B; other site 243159004109 D-loop; other site 243159004110 H-loop/switch region; other site 243159004111 Protein of unknown function (DUF465); Region: DUF465; cl01070 243159004112 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723 243159004113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159004114 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243159004115 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 243159004116 YccA-like proteins; Region: YccA_like; cd10433 243159004117 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 243159004118 exodeoxyribonuclease X; Provisional; Region: PRK07983 243159004119 active site 243159004120 catalytic site [active] 243159004121 substrate binding site [chemical binding]; other site 243159004122 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 243159004123 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 243159004124 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 243159004125 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243159004126 FAD binding domain; Region: FAD_binding_4; pfam01565 243159004127 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 243159004128 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243159004129 Cysteine-rich domain; Region: CCG; pfam02754 243159004130 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 243159004131 pantoate--beta-alanine ligase; Region: panC; TIGR00018 243159004132 Pantoate-beta-alanine ligase; Region: PanC; cd00560 243159004133 active site 243159004134 ATP-binding site [chemical binding]; other site 243159004135 pantoate-binding site; other site 243159004136 HXXH motif; other site 243159004137 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 243159004138 oligomerization interface [polypeptide binding]; other site 243159004139 active site 243159004140 metal binding site [ion binding]; metal-binding site 243159004141 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 243159004142 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 243159004143 Substrate-binding site [chemical binding]; other site 243159004144 Substrate specificity [chemical binding]; other site 243159004145 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 243159004146 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 243159004147 active site 243159004148 NTP binding site [chemical binding]; other site 243159004149 metal binding triad [ion binding]; metal-binding site 243159004150 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 243159004151 poly(A) polymerase; Region: pcnB; TIGR01942 243159004152 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 243159004153 active site 243159004154 NTP binding site [chemical binding]; other site 243159004155 metal binding triad [ion binding]; metal-binding site 243159004156 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 243159004157 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 243159004158 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 243159004159 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 243159004160 Ligand binding site; other site 243159004161 Putative Catalytic site; other site 243159004162 DXD motif; other site 243159004163 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 243159004164 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243159004165 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 243159004166 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 243159004167 active site 243159004168 GMP synthase; Reviewed; Region: guaA; PRK00074 243159004169 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 243159004170 AMP/PPi binding site [chemical binding]; other site 243159004171 candidate oxyanion hole; other site 243159004172 catalytic triad [active] 243159004173 potential glutamine specificity residues [chemical binding]; other site 243159004174 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 243159004175 ATP Binding subdomain [chemical binding]; other site 243159004176 Ligand Binding sites [chemical binding]; other site 243159004177 Dimerization subdomain; other site 243159004178 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 243159004179 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 243159004180 oligomeric interface; other site 243159004181 putative active site [active] 243159004182 homodimer interface [polypeptide binding]; other site 243159004183 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 243159004184 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243159004185 gamma-glutamyl kinase; Provisional; Region: PRK05429 243159004186 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 243159004187 nucleotide binding site [chemical binding]; other site 243159004188 homotetrameric interface [polypeptide binding]; other site 243159004189 putative phosphate binding site [ion binding]; other site 243159004190 putative allosteric binding site; other site 243159004191 PUA domain; Region: PUA; pfam01472 243159004192 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243159004193 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 243159004194 dinuclear metal binding motif [ion binding]; other site 243159004195 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 243159004196 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 243159004197 Peptidase family M50; Region: Peptidase_M50; pfam02163 243159004198 active site 243159004199 putative substrate binding region [chemical binding]; other site 243159004200 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 243159004201 active site 243159004202 HIGH motif; other site 243159004203 dimer interface [polypeptide binding]; other site 243159004204 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243159004205 active site 243159004206 KMSKS motif; other site 243159004207 ScpA/B protein; Region: ScpA_ScpB; cl00598 243159004208 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 243159004209 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 243159004210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 243159004211 NAD binding site [chemical binding]; other site 243159004212 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 243159004213 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243159004214 RNA binding surface [nucleotide binding]; other site 243159004215 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 243159004216 probable active site [active] 243159004217 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 243159004218 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243159004219 minor groove reading motif; other site 243159004220 helix-hairpin-helix signature motif; other site 243159004221 substrate binding pocket [chemical binding]; other site 243159004222 active site 243159004223 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243159004224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159004225 putative substrate translocation pore; other site 243159004226 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 243159004227 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 243159004228 putative homodimer interface [polypeptide binding]; other site 243159004229 putative active site pocket [active] 243159004230 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 243159004231 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 243159004232 substrate binding pocket [chemical binding]; other site 243159004233 pyruvate kinase; Provisional; Region: PRK05826 243159004234 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 243159004235 domain interfaces; other site 243159004236 active site 243159004237 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 243159004238 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 243159004239 putative active site; other site 243159004240 catalytic residue [active] 243159004241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 243159004242 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243159004243 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243159004244 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 243159004245 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 243159004246 putative substrate binding site [chemical binding]; other site 243159004247 putative ATP binding site [chemical binding]; other site 243159004248 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 243159004249 phosphate:H+ symporter; Region: 2A0109; TIGR00887 243159004250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159004251 putative substrate translocation pore; other site 243159004252 Acetokinase family; Region: Acetate_kinase; cl17229 243159004253 propionate/acetate kinase; Provisional; Region: PRK12379 243159004254 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243159004255 E3 interaction surface; other site 243159004256 lipoyl attachment site [posttranslational modification]; other site 243159004257 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 243159004258 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243159004259 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 243159004260 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 243159004261 alpha subunit interface [polypeptide binding]; other site 243159004262 TPP binding site [chemical binding]; other site 243159004263 heterodimer interface [polypeptide binding]; other site 243159004264 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243159004265 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 243159004266 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 243159004267 tetramer interface [polypeptide binding]; other site 243159004268 TPP-binding site [chemical binding]; other site 243159004269 heterodimer interface [polypeptide binding]; other site 243159004270 phosphorylation loop region [posttranslational modification] 243159004271 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 243159004272 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 243159004273 phosphoglyceromutase; Provisional; Region: PRK05434 243159004274 phosphoenolpyruvate synthase; Validated; Region: PRK06464 243159004275 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 243159004276 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243159004277 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243159004278 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 243159004279 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 243159004280 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 243159004281 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 243159004282 Sporulation related domain; Region: SPOR; pfam05036 243159004283 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 243159004284 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 243159004285 metal binding site [ion binding]; metal-binding site 243159004286 dimer interface [polypeptide binding]; other site 243159004287 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 243159004288 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 243159004289 trimer interface [polypeptide binding]; other site 243159004290 active site 243159004291 substrate binding site [chemical binding]; other site 243159004292 CoA binding site [chemical binding]; other site 243159004293 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 243159004294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243159004295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159004296 homodimer interface [polypeptide binding]; other site 243159004297 catalytic residue [active] 243159004298 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243159004299 phosphoglycolate phosphatase; Provisional; Region: PRK13226 243159004300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243159004301 motif II; other site 243159004302 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 243159004303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159004304 S-adenosylmethionine binding site [chemical binding]; other site 243159004305 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 243159004306 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 243159004307 active site 243159004308 putative substrate binding pocket [chemical binding]; other site 243159004309 Transglycosylase SLT domain; Region: SLT_2; pfam13406 243159004310 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243159004311 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243159004312 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243159004313 NlpC/P60 family; Region: NLPC_P60; pfam00877 243159004314 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 243159004315 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 243159004316 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 243159004317 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 243159004318 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243159004319 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243159004320 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243159004321 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243159004322 DNA binding residues [nucleotide binding] 243159004323 Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; Region: Sec7; cl00136 243159004324 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 243159004325 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243159004326 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 243159004327 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 243159004328 TPP-binding site [chemical binding]; other site 243159004329 dimer interface [polypeptide binding]; other site 243159004330 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243159004331 PYR/PP interface [polypeptide binding]; other site 243159004332 dimer interface [polypeptide binding]; other site 243159004333 TPP binding site [chemical binding]; other site 243159004334 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243159004335 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243159004336 4Fe-4S binding domain; Region: Fer4; pfam00037 243159004337 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 243159004338 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 243159004339 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 243159004340 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 243159004341 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 243159004342 gating phenylalanine in ion channel; other site 243159004343 AlkA N-terminal domain; Region: AlkA_N; cl05528 243159004344 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 243159004345 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243159004346 minor groove reading motif; other site 243159004347 helix-hairpin-helix signature motif; other site 243159004348 active site 243159004349 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243159004350 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 243159004351 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243159004352 active site 243159004353 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243159004354 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243159004355 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243159004356 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 243159004357 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243159004358 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 243159004359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243159004360 NAD(P) binding site [chemical binding]; other site 243159004361 active site 243159004362 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cl07672 243159004363 Domain interface; other site 243159004364 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 243159004365 aromatic arch; other site 243159004366 DCoH dimer interaction site [polypeptide binding]; other site 243159004367 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 243159004368 DCoH tetramer interaction site [polypeptide binding]; other site 243159004369 substrate binding site [chemical binding]; other site 243159004370 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243159004371 metal-binding site [ion binding] 243159004372 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 243159004373 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 243159004374 LexA repressor; Validated; Region: PRK00215 243159004375 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 243159004376 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 243159004377 Catalytic site [active] 243159004378 Cell division inhibitor SulA; Region: SulA; cl01880 243159004379 DNA Polymerase Y-family; Region: PolY_like; cd03468 243159004380 active site 243159004381 DNA binding site [nucleotide binding] 243159004382 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 243159004383 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 243159004384 putative active site [active] 243159004385 putative PHP Thumb interface [polypeptide binding]; other site 243159004386 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 243159004387 generic binding surface II; other site 243159004388 generic binding surface I; other site 243159004389 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243159004390 aminopeptidase N; Provisional; Region: pepN; PRK14015 243159004391 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 243159004392 active site 243159004393 Zn binding site [ion binding]; other site 243159004394 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 243159004395 putative active site [active] 243159004396 putative metal binding residues [ion binding]; other site 243159004397 signature motif; other site 243159004398 putative triphosphate binding site [ion binding]; other site 243159004399 CHAD domain; Region: CHAD; pfam05235 243159004400 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243159004401 ParA-like protein; Provisional; Region: PHA02518 243159004402 P-loop; other site 243159004403 Magnesium ion binding site [ion binding]; other site 243159004404 polyphosphate kinase; Provisional; Region: PRK05443 243159004405 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 243159004406 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 243159004407 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 243159004408 putative domain interface [polypeptide binding]; other site 243159004409 putative active site [active] 243159004410 catalytic site [active] 243159004411 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 243159004412 putative domain interface [polypeptide binding]; other site 243159004413 putative active site [active] 243159004414 catalytic site [active] 243159004415 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 243159004416 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 243159004417 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 243159004418 homodimer interface [polypeptide binding]; other site 243159004419 NADP binding site [chemical binding]; other site 243159004420 substrate binding site [chemical binding]; other site 243159004421 multidrug efflux protein; Reviewed; Region: PRK09579 243159004422 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243159004423 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243159004424 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159004425 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243159004426 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243159004427 Maf-like protein; Region: Maf; pfam02545 243159004428 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 243159004429 active site 243159004430 dimer interface [polypeptide binding]; other site 243159004431 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 243159004432 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 243159004433 bacterial Hfq-like; Region: Hfq; cd01716 243159004434 hexamer interface [polypeptide binding]; other site 243159004435 Sm1 motif; other site 243159004436 RNA binding site [nucleotide binding]; other site 243159004437 Sm2 motif; other site 243159004438 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 243159004439 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 243159004440 HflX GTPase family; Region: HflX; cd01878 243159004441 G1 box; other site 243159004442 GTP/Mg2+ binding site [chemical binding]; other site 243159004443 Switch I region; other site 243159004444 G2 box; other site 243159004445 G3 box; other site 243159004446 Switch II region; other site 243159004447 G4 box; other site 243159004448 G5 box; other site 243159004449 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 243159004450 HflK protein; Region: hflK; TIGR01933 243159004451 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 243159004452 HflC protein; Region: hflC; TIGR01932 243159004453 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 243159004454 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 243159004455 dimer interface [polypeptide binding]; other site 243159004456 motif 1; other site 243159004457 active site 243159004458 motif 2; other site 243159004459 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 243159004460 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 243159004461 GDP-binding site [chemical binding]; other site 243159004462 ACT binding site; other site 243159004463 IMP binding site; other site 243159004464 ribonuclease R; Region: RNase_R; TIGR02063 243159004465 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 243159004466 RNB domain; Region: RNB; pfam00773 243159004467 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 243159004468 RNA binding site [nucleotide binding]; other site 243159004469 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 243159004470 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 243159004471 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243159004472 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243159004473 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 243159004474 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 243159004475 putative MPT binding site; other site 243159004476 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243159004477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243159004478 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243159004479 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 243159004480 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 243159004481 active site 243159004482 substrate binding site [chemical binding]; other site 243159004483 cosubstrate binding site; other site 243159004484 catalytic site [active] 243159004485 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 243159004486 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 243159004487 dimerization interface [polypeptide binding]; other site 243159004488 putative ATP binding site [chemical binding]; other site 243159004489 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 243159004490 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 243159004491 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 243159004492 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 243159004493 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 243159004494 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 243159004495 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 243159004496 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 243159004497 putative phosphate acyltransferase; Provisional; Region: PRK05331 243159004498 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 243159004499 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 243159004500 dimer interface [polypeptide binding]; other site 243159004501 active site 243159004502 CoA binding pocket [chemical binding]; other site 243159004503 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 243159004504 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243159004505 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 243159004506 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 243159004507 NAD(P) binding site [chemical binding]; other site 243159004508 homotetramer interface [polypeptide binding]; other site 243159004509 homodimer interface [polypeptide binding]; other site 243159004510 active site 243159004511 acyl carrier protein; Provisional; Region: acpP; PRK00982 243159004512 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 243159004513 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243159004514 dimer interface [polypeptide binding]; other site 243159004515 active site 243159004516 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 243159004517 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 243159004518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159004519 catalytic residue [active] 243159004520 thymidylate kinase; Validated; Region: tmk; PRK00698 243159004521 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 243159004522 TMP-binding site; other site 243159004523 ATP-binding site [chemical binding]; other site 243159004524 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 243159004525 DNA polymerase III subunit delta'; Validated; Region: PRK08485 243159004526 PilZ domain; Region: PilZ; cl01260 243159004527 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 243159004528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159004529 Walker A motif; other site 243159004530 ATP binding site [chemical binding]; other site 243159004531 Walker B motif; other site 243159004532 arginine finger; other site 243159004533 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 243159004534 hypothetical protein; Validated; Region: PRK00153 243159004535 recombination protein RecR; Reviewed; Region: recR; PRK00076 243159004536 RecR protein; Region: RecR; pfam02132 243159004537 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 243159004538 putative active site [active] 243159004539 putative metal-binding site [ion binding]; other site 243159004540 tetramer interface [polypeptide binding]; other site 243159004541 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243159004542 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 243159004543 putative ATP binding site [chemical binding]; other site 243159004544 putative substrate binding site [chemical binding]; other site 243159004545 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243159004546 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 243159004547 inhibitor-cofactor binding pocket; inhibition site 243159004548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159004549 catalytic residue [active] 243159004550 FOG: CBS domain [General function prediction only]; Region: COG0517 243159004551 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 243159004552 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 243159004553 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 243159004554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159004555 ATP binding site [chemical binding]; other site 243159004556 Mg2+ binding site [ion binding]; other site 243159004557 G-X-G motif; other site 243159004558 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 243159004559 ATP binding site [chemical binding]; other site 243159004560 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 243159004561 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 243159004562 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 243159004563 active site 243159004564 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 243159004565 active site 243159004566 multimer interface [polypeptide binding]; other site 243159004567 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 243159004568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159004569 FeS/SAM binding site; other site 243159004570 TPR repeat; Region: TPR_11; pfam13414 243159004571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159004572 binding surface 243159004573 TPR motif; other site 243159004574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 243159004575 binding surface 243159004576 TPR motif; other site 243159004577 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243159004578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243159004579 non-specific DNA binding site [nucleotide binding]; other site 243159004580 salt bridge; other site 243159004581 sequence-specific DNA binding site [nucleotide binding]; other site 243159004582 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 243159004583 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 243159004584 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 243159004585 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 243159004586 histidyl-tRNA synthetase; Region: hisS; TIGR00442 243159004587 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 243159004588 dimer interface [polypeptide binding]; other site 243159004589 motif 1; other site 243159004590 active site 243159004591 motif 2; other site 243159004592 motif 3; other site 243159004593 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 243159004594 anticodon binding site; other site 243159004595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 243159004596 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 243159004597 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243159004598 Trp docking motif [polypeptide binding]; other site 243159004599 active site 243159004600 GTP-binding protein Der; Reviewed; Region: PRK00093 243159004601 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 243159004602 G1 box; other site 243159004603 GTP/Mg2+ binding site [chemical binding]; other site 243159004604 Switch I region; other site 243159004605 G2 box; other site 243159004606 Switch II region; other site 243159004607 G3 box; other site 243159004608 G4 box; other site 243159004609 G5 box; other site 243159004610 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 243159004611 G1 box; other site 243159004612 GTP/Mg2+ binding site [chemical binding]; other site 243159004613 Switch I region; other site 243159004614 G2 box; other site 243159004615 G3 box; other site 243159004616 Switch II region; other site 243159004617 G4 box; other site 243159004618 G5 box; other site 243159004619 PBP superfamily domain; Region: PBP_like_2; cl17296 243159004620 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 243159004621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243159004622 dimer interface [polypeptide binding]; other site 243159004623 conserved gate region; other site 243159004624 putative PBP binding loops; other site 243159004625 ABC-ATPase subunit interface; other site 243159004626 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 243159004627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243159004628 dimer interface [polypeptide binding]; other site 243159004629 conserved gate region; other site 243159004630 putative PBP binding loops; other site 243159004631 ABC-ATPase subunit interface; other site 243159004632 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 243159004633 Hemerythrin-like domain; Region: Hr-like; cd12108 243159004634 Fe binding site [ion binding]; other site 243159004635 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243159004636 hypothetical protein; Provisional; Region: PRK10621 243159004637 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243159004638 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243159004639 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243159004640 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243159004641 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159004642 Outer membrane efflux protein; Region: OEP; pfam02321 243159004643 Outer membrane efflux protein; Region: OEP; pfam02321 243159004644 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 243159004645 substrate binding site [chemical binding]; other site 243159004646 Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968 243159004647 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 243159004648 diiron binding motif [ion binding]; other site 243159004649 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243159004650 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243159004651 metal binding site 2 [ion binding]; metal-binding site 243159004652 putative DNA binding helix; other site 243159004653 metal binding site 1 [ion binding]; metal-binding site 243159004654 structural Zn2+ binding site [ion binding]; other site 243159004655 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 243159004656 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 243159004657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 243159004658 Family of unknown function (DUF490); Region: DUF490; pfam04357 243159004659 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 243159004660 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243159004661 Surface antigen; Region: Bac_surface_Ag; pfam01103 243159004662 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 243159004663 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 243159004664 muropeptide transporter; Validated; Region: ampG; cl17669 243159004665 Cytochrome c; Region: Cytochrom_C; cl11414 243159004666 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 243159004667 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 243159004668 putative di-iron ligands [ion binding]; other site 243159004669 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243159004670 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 243159004671 putative NAD(P) binding site [chemical binding]; other site 243159004672 active site 243159004673 putative substrate binding site [chemical binding]; other site 243159004674 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 243159004675 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 243159004676 NADP binding site [chemical binding]; other site 243159004677 homopentamer interface [polypeptide binding]; other site 243159004678 substrate binding site [chemical binding]; other site 243159004679 active site 243159004680 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 243159004681 putative cation:proton antiport protein; Provisional; Region: PRK10669 243159004682 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243159004683 TrkA-N domain; Region: TrkA_N; pfam02254 243159004684 TrkA-C domain; Region: TrkA_C; pfam02080 243159004685 acetyl-CoA synthetase; Provisional; Region: PRK00174 243159004686 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 243159004687 active site 243159004688 CoA binding site [chemical binding]; other site 243159004689 acyl-activating enzyme (AAE) consensus motif; other site 243159004690 AMP binding site [chemical binding]; other site 243159004691 acetate binding site [chemical binding]; other site 243159004692 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 243159004693 Clp amino terminal domain; Region: Clp_N; pfam02861 243159004694 Clp amino terminal domain; Region: Clp_N; pfam02861 243159004695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159004696 Walker A motif; other site 243159004697 ATP binding site [chemical binding]; other site 243159004698 Walker B motif; other site 243159004699 arginine finger; other site 243159004700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159004701 Walker A motif; other site 243159004702 ATP binding site [chemical binding]; other site 243159004703 Walker B motif; other site 243159004704 arginine finger; other site 243159004705 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243159004706 MFS_1 like family; Region: MFS_1_like; pfam12832 243159004707 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243159004708 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 243159004709 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 243159004710 Tetramer interface [polypeptide binding]; other site 243159004711 active site 243159004712 FMN-binding site [chemical binding]; other site 243159004713 putative GTP cyclohydrolase; Provisional; Region: PRK13674 243159004714 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 243159004715 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 243159004716 TPP-binding site; other site 243159004717 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243159004718 PYR/PP interface [polypeptide binding]; other site 243159004719 dimer interface [polypeptide binding]; other site 243159004720 TPP binding site [chemical binding]; other site 243159004721 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243159004722 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243159004723 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 243159004724 substrate binding pocket [chemical binding]; other site 243159004725 chain length determination region; other site 243159004726 substrate-Mg2+ binding site; other site 243159004727 catalytic residues [active] 243159004728 aspartate-rich region 1; other site 243159004729 active site lid residues [active] 243159004730 aspartate-rich region 2; other site 243159004731 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 243159004732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159004733 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243159004734 putative substrate translocation pore; other site 243159004735 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 243159004736 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 243159004737 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243159004738 catalytic residues [active] 243159004739 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 243159004740 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 243159004741 generic binding surface II; other site 243159004742 generic binding surface I; other site 243159004743 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243159004744 active site 243159004745 PQQ-like domain; Region: PQQ_2; pfam13360 243159004746 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243159004747 Trp docking motif [polypeptide binding]; other site 243159004748 active site 243159004749 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243159004750 active site 243159004751 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 243159004752 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 243159004753 substrate binding site [chemical binding]; other site 243159004754 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243159004755 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 243159004756 putative active site [active] 243159004757 putative metal binding site [ion binding]; other site 243159004758 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 243159004759 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243159004760 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243159004761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243159004762 motif II; other site 243159004763 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243159004764 2-isopropylmalate synthase; Validated; Region: PRK03739 243159004765 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 243159004766 active site 243159004767 catalytic residues [active] 243159004768 metal binding site [ion binding]; metal-binding site 243159004769 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 243159004770 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 243159004771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243159004772 putative DNA binding site [nucleotide binding]; other site 243159004773 putative Zn2+ binding site [ion binding]; other site 243159004774 AsnC family; Region: AsnC_trans_reg; pfam01037 243159004775 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 243159004776 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 243159004777 gating phenylalanine in ion channel; other site 243159004778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159004779 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 243159004780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243159004781 dimerization interface [polypeptide binding]; other site 243159004782 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 243159004783 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 243159004784 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 243159004785 Autoinducer binding domain; Region: Autoind_bind; pfam03472 243159004786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243159004787 DNA binding residues [nucleotide binding] 243159004788 dimerization interface [polypeptide binding]; other site 243159004789 Autoinducer synthetase; Region: Autoind_synth; cl17404 243159004790 EVE domain; Region: EVE; cl00728 243159004791 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 243159004792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159004793 Coenzyme A binding pocket [chemical binding]; other site 243159004794 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 243159004795 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 243159004796 conserved cys residue [active] 243159004797 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 243159004798 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243159004799 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243159004800 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 243159004801 putative hydrophobic ligand binding site [chemical binding]; other site 243159004802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243159004803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243159004804 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243159004805 MarR family; Region: MarR_2; pfam12802 243159004806 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243159004807 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243159004808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159004809 Coenzyme A binding pocket [chemical binding]; other site 243159004810 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 243159004811 Uncharacterized conserved protein [Function unknown]; Region: COG0393 243159004812 Uncharacterized conserved protein [Function unknown]; Region: COG0393 243159004813 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 243159004814 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 243159004815 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 243159004816 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243159004817 metal-binding site [ion binding] 243159004818 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 243159004819 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243159004820 metal-binding site [ion binding] 243159004821 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243159004822 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 243159004823 aspartate aminotransferase; Provisional; Region: PRK05764 243159004824 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243159004825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159004826 homodimer interface [polypeptide binding]; other site 243159004827 catalytic residue [active] 243159004828 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 243159004829 ATP-grasp domain; Region: ATP-grasp; pfam02222 243159004830 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 243159004831 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243159004832 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 243159004833 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 243159004834 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 243159004835 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243159004836 dimerization interface [polypeptide binding]; other site 243159004837 putative DNA binding site [nucleotide binding]; other site 243159004838 putative Zn2+ binding site [ion binding]; other site 243159004839 tRNA dihydrouridine synthase A; Region: yjbN; TIGR00742 243159004840 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 243159004841 FMN binding site [chemical binding]; other site 243159004842 active site 243159004843 catalytic residues [active] 243159004844 substrate binding site [chemical binding]; other site 243159004845 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 243159004846 CAP-like domain; other site 243159004847 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 243159004848 active site 243159004849 primary dimer interface [polypeptide binding]; other site 243159004850 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 243159004851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159004852 ATP binding site [chemical binding]; other site 243159004853 Mg2+ binding site [ion binding]; other site 243159004854 G-X-G motif; other site 243159004855 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 243159004856 anchoring element; other site 243159004857 dimer interface [polypeptide binding]; other site 243159004858 ATP binding site [chemical binding]; other site 243159004859 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 243159004860 active site 243159004861 putative metal-binding site [ion binding]; other site 243159004862 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 243159004863 sensor protein QseC; Provisional; Region: PRK10337 243159004864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243159004865 dimer interface [polypeptide binding]; other site 243159004866 phosphorylation site [posttranslational modification] 243159004867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159004868 ATP binding site [chemical binding]; other site 243159004869 Mg2+ binding site [ion binding]; other site 243159004870 G-X-G motif; other site 243159004871 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243159004872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159004873 active site 243159004874 phosphorylation site [posttranslational modification] 243159004875 intermolecular recognition site; other site 243159004876 dimerization interface [polypeptide binding]; other site 243159004877 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243159004878 DNA binding site [nucleotide binding] 243159004879 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 243159004880 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243159004881 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243159004882 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243159004883 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159004884 Outer membrane efflux protein; Region: OEP; pfam02321 243159004885 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243159004886 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243159004887 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243159004888 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243159004889 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243159004890 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243159004891 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 243159004892 EamA-like transporter family; Region: EamA; pfam00892 243159004893 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243159004894 putative phosphoketolase; Provisional; Region: PRK05261 243159004895 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 243159004896 TPP-binding site; other site 243159004897 XFP C-terminal domain; Region: XFP_C; pfam09363 243159004898 Protein of unknown function, DUF481; Region: DUF481; cl01213 243159004899 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 243159004900 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 243159004901 Protein export membrane protein; Region: SecD_SecF; pfam02355 243159004902 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 243159004903 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 243159004904 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 243159004905 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 243159004906 Preprotein translocase subunit; Region: YajC; pfam02699 243159004907 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 243159004908 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 243159004909 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 243159004910 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 243159004911 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 243159004912 Domain of unknown function DUF21; Region: DUF21; pfam01595 243159004913 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243159004914 Transporter associated domain; Region: CorC_HlyC; smart01091 243159004915 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 243159004916 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 243159004917 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243159004918 homodimer interface [polypeptide binding]; other site 243159004919 substrate-cofactor binding pocket; other site 243159004920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159004921 catalytic residue [active] 243159004922 amidophosphoribosyltransferase; Provisional; Region: PRK09123 243159004923 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 243159004924 active site 243159004925 tetramer interface [polypeptide binding]; other site 243159004926 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243159004927 active site 243159004928 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 243159004929 Colicin V production protein; Region: Colicin_V; pfam02674 243159004930 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 243159004931 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 243159004932 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243159004933 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 243159004934 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 243159004935 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 243159004936 substrate binding site [chemical binding]; other site 243159004937 active site 243159004938 catalytic residues [active] 243159004939 heterodimer interface [polypeptide binding]; other site 243159004940 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 243159004941 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 243159004942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159004943 catalytic residue [active] 243159004944 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 243159004945 active site 243159004946 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 243159004947 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 243159004948 dimerization interface 3.5A [polypeptide binding]; other site 243159004949 active site 243159004950 FimV N-terminal domain; Region: FimV_core; TIGR03505 243159004951 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 243159004952 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 243159004953 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 243159004954 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 243159004955 tartrate dehydrogenase; Region: TTC; TIGR02089 243159004956 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 243159004957 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 243159004958 GTP binding site; other site 243159004959 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 243159004960 Walker A motif; other site 243159004961 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 243159004962 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 243159004963 dimer interface [polypeptide binding]; other site 243159004964 putative functional site; other site 243159004965 putative MPT binding site; other site 243159004966 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 243159004967 PLD-like domain; Region: PLDc_2; pfam13091 243159004968 putative active site [active] 243159004969 catalytic site [active] 243159004970 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 243159004971 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 243159004972 oligomer interface [polypeptide binding]; other site 243159004973 tandem repeat interface [polypeptide binding]; other site 243159004974 active site residues [active] 243159004975 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 243159004976 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 243159004977 tandem repeat interface [polypeptide binding]; other site 243159004978 oligomer interface [polypeptide binding]; other site 243159004979 active site residues [active] 243159004980 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 243159004981 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 243159004982 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 243159004983 active site 243159004984 catalytic site [active] 243159004985 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 243159004986 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 243159004987 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 243159004988 catalytic site [active] 243159004989 active site 243159004990 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 243159004991 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 243159004992 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159004993 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243159004994 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243159004995 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243159004996 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 243159004997 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 243159004998 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 243159004999 putative NAD(P) binding site [chemical binding]; other site 243159005000 putative substrate binding site [chemical binding]; other site 243159005001 catalytic Zn binding site [ion binding]; other site 243159005002 structural Zn binding site [ion binding]; other site 243159005003 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243159005004 Peptidase family M48; Region: Peptidase_M48; cl12018 243159005005 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243159005006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159005007 putative substrate translocation pore; other site 243159005008 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 243159005009 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 243159005010 YcaO-like family; Region: YcaO; pfam02624 243159005011 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243159005012 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243159005013 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159005014 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243159005015 Protein export membrane protein; Region: SecD_SecF; cl14618 243159005016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159005017 AAA domain; Region: AAA_23; pfam13476 243159005018 Walker A/P-loop; other site 243159005019 ATP binding site [chemical binding]; other site 243159005020 ABC transporter; Region: ABC_tran; pfam00005 243159005021 Q-loop/lid; other site 243159005022 ABC transporter signature motif; other site 243159005023 Walker B; other site 243159005024 D-loop; other site 243159005025 H-loop/switch region; other site 243159005026 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 243159005027 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 243159005028 GatB domain; Region: GatB_Yqey; smart00845 243159005029 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 243159005030 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 243159005031 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 243159005032 VacJ like lipoprotein; Region: VacJ; cl01073 243159005033 hopanoid biosynthesis associated membrane protein HpnM; Region: HpnM; TIGR03481 243159005034 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 243159005035 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159005036 FeS/SAM binding site; other site 243159005037 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 243159005038 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 243159005039 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 243159005040 dinuclear metal binding motif [ion binding]; other site 243159005041 putative membrane protein; Region: HpnL; TIGR03476 243159005042 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 243159005043 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 243159005044 putative active site [active] 243159005045 YdjC motif; other site 243159005046 Mg binding site [ion binding]; other site 243159005047 putative homodimer interface [polypeptide binding]; other site 243159005048 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 243159005049 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 243159005050 B12 binding site [chemical binding]; other site 243159005051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159005052 FeS/SAM binding site; other site 243159005053 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 243159005054 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 243159005055 ligand binding site; other site 243159005056 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 243159005057 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 243159005058 putative NADP binding site [chemical binding]; other site 243159005059 putative substrate binding site [chemical binding]; other site 243159005060 active site 243159005061 hopanoid-associated phosphorylase; Region: HpnG; TIGR03468 243159005062 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 243159005063 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 243159005064 Active site cavity [active] 243159005065 catalytic acid [active] 243159005066 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 243159005067 active site lid residues [active] 243159005068 substrate binding pocket [chemical binding]; other site 243159005069 catalytic residues [active] 243159005070 substrate-Mg2+ binding site; other site 243159005071 aspartate-rich region 1; other site 243159005072 aspartate-rich region 2; other site 243159005073 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 243159005074 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 243159005075 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 243159005076 preprotein translocase subunit SecB; Validated; Region: PRK05751 243159005077 SecA binding site; other site 243159005078 Preprotein binding site; other site 243159005079 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 243159005080 oligomeric interface; other site 243159005081 putative active site [active] 243159005082 homodimer interface [polypeptide binding]; other site 243159005083 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 243159005084 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 243159005085 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243159005086 NAD(P) binding site [chemical binding]; other site 243159005087 catalytic residues [active] 243159005088 prolyl-tRNA synthetase; Provisional; Region: PRK09194 243159005089 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 243159005090 dimer interface [polypeptide binding]; other site 243159005091 motif 1; other site 243159005092 active site 243159005093 motif 2; other site 243159005094 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 243159005095 putative deacylase active site [active] 243159005096 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243159005097 active site 243159005098 motif 3; other site 243159005099 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 243159005100 anticodon binding site; other site 243159005101 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243159005102 Ligand Binding Site [chemical binding]; other site 243159005103 Protein of unknown function (DUF330); Region: DUF330; cl01135 243159005104 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243159005105 mce related protein; Region: MCE; pfam02470 243159005106 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 243159005107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159005108 S-adenosylmethionine binding site [chemical binding]; other site 243159005109 Isochorismatase family; Region: Isochorismatase; pfam00857 243159005110 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 243159005111 catalytic triad [active] 243159005112 dimer interface [polypeptide binding]; other site 243159005113 conserved cis-peptide bond; other site 243159005114 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 243159005115 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 243159005116 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 243159005117 protein binding site [polypeptide binding]; other site 243159005118 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 243159005119 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243159005120 putative active site [active] 243159005121 metal binding site [ion binding]; metal-binding site 243159005122 homodimer binding site [polypeptide binding]; other site 243159005123 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 243159005124 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 243159005125 Cell division protein ZapA; Region: ZapA; pfam05164 243159005126 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 243159005127 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 243159005128 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243159005129 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 243159005130 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 243159005131 5S rRNA interface [nucleotide binding]; other site 243159005132 CTC domain interface [polypeptide binding]; other site 243159005133 L16 interface [polypeptide binding]; other site 243159005134 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 243159005135 putative active site [active] 243159005136 catalytic residue [active] 243159005137 GTP-binding protein YchF; Reviewed; Region: PRK09601 243159005138 YchF GTPase; Region: YchF; cd01900 243159005139 G1 box; other site 243159005140 GTP/Mg2+ binding site [chemical binding]; other site 243159005141 Switch I region; other site 243159005142 G2 box; other site 243159005143 Switch II region; other site 243159005144 G3 box; other site 243159005145 G4 box; other site 243159005146 G5 box; other site 243159005147 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 243159005148 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 243159005149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243159005150 non-specific DNA binding site [nucleotide binding]; other site 243159005151 salt bridge; other site 243159005152 sequence-specific DNA binding site [nucleotide binding]; other site 243159005153 Cupin domain; Region: Cupin_2; pfam07883 243159005154 hydrogenase 4 subunit B; Validated; Region: PRK06521 243159005155 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243159005156 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 243159005157 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 243159005158 hydrogenase 4 subunit F; Validated; Region: PRK06458 243159005159 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243159005160 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 243159005161 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 243159005162 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 243159005163 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 243159005164 ribulose bisphosphate carboxylase; Provisional; Region: PRK13475 243159005165 Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211 243159005166 dimer interface [polypeptide binding]; other site 243159005167 active site 243159005168 catalytic residue [active] 243159005169 metal binding site [ion binding]; metal-binding site 243159005170 MoxR-like ATPases [General function prediction only]; Region: COG0714 243159005171 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 243159005172 Walker A motif; other site 243159005173 ATP binding site [chemical binding]; other site 243159005174 Walker B motif; other site 243159005175 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 243159005176 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 243159005177 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243159005178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159005179 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 243159005180 putative dimerization interface [polypeptide binding]; other site 243159005181 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 243159005182 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 243159005183 PhnA protein; Region: PhnA; pfam03831 243159005184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243159005185 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 243159005186 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 243159005187 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 243159005188 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243159005189 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159005190 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 243159005191 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 243159005192 putative active site [active] 243159005193 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243159005194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159005195 Walker A/P-loop; other site 243159005196 ATP binding site [chemical binding]; other site 243159005197 Q-loop/lid; other site 243159005198 ABC transporter signature motif; other site 243159005199 Walker B; other site 243159005200 D-loop; other site 243159005201 H-loop/switch region; other site 243159005202 Outer membrane efflux protein; Region: OEP; pfam02321 243159005203 Outer membrane efflux protein; Region: OEP; pfam02321 243159005204 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 243159005205 putative active site [active] 243159005206 putative metal binding site [ion binding]; other site 243159005207 Cna protein B-type domain; Region: Cna_B_2; pfam13715 243159005208 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 243159005209 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 243159005210 Beta-lactamase; Region: Beta-lactamase; pfam00144 243159005211 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 243159005212 putative active site [active] 243159005213 Ap4A binding site [chemical binding]; other site 243159005214 nudix motif; other site 243159005215 putative metal binding site [ion binding]; other site 243159005216 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 243159005217 nudix motif; other site 243159005218 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 243159005219 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243159005220 RNA binding surface [nucleotide binding]; other site 243159005221 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 243159005222 active site 243159005223 uracil binding [chemical binding]; other site 243159005224 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 243159005225 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 243159005226 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 243159005227 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243159005228 molybdopterin cofactor binding site; other site 243159005229 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243159005230 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243159005231 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 243159005232 putative molybdopterin cofactor binding site; other site 243159005233 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 243159005234 4Fe-4S binding domain; Region: Fer4; pfam00037 243159005235 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 243159005236 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 243159005237 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243159005238 Ligand Binding Site [chemical binding]; other site 243159005239 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243159005240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159005241 putative substrate translocation pore; other site 243159005242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159005243 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243159005244 MarR family; Region: MarR_2; pfam12802 243159005245 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 243159005246 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 243159005247 Part of AAA domain; Region: AAA_19; pfam13245 243159005248 Family description; Region: UvrD_C_2; pfam13538 243159005249 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 243159005250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159005251 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 243159005252 Walker A/P-loop; other site 243159005253 ATP binding site [chemical binding]; other site 243159005254 Q-loop/lid; other site 243159005255 ABC transporter signature motif; other site 243159005256 Walker B; other site 243159005257 D-loop; other site 243159005258 H-loop/switch region; other site 243159005259 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 243159005260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243159005261 dimer interface [polypeptide binding]; other site 243159005262 conserved gate region; other site 243159005263 putative PBP binding loops; other site 243159005264 ABC-ATPase subunit interface; other site 243159005265 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 243159005266 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 243159005267 active site 243159005268 metal binding site [ion binding]; metal-binding site 243159005269 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 243159005270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159005271 ATP binding site [chemical binding]; other site 243159005272 putative Mg++ binding site [ion binding]; other site 243159005273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243159005274 nucleotide binding region [chemical binding]; other site 243159005275 ATP-binding site [chemical binding]; other site 243159005276 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 243159005277 HRDC domain; Region: HRDC; pfam00570 243159005278 iron donor protein CyaY; Region: FeS_CyaY; TIGR03421 243159005279 putative iron binding site [ion binding]; other site 243159005280 EVE domain; Region: EVE; cl00728 243159005281 Predicted permeases [General function prediction only]; Region: COG0795 243159005282 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 243159005283 Predicted permeases [General function prediction only]; Region: COG0795 243159005284 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 243159005285 multifunctional aminopeptidase A; Provisional; Region: PRK00913 243159005286 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 243159005287 interface (dimer of trimers) [polypeptide binding]; other site 243159005288 Substrate-binding/catalytic site; other site 243159005289 Zn-binding sites [ion binding]; other site 243159005290 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 243159005291 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 243159005292 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243159005293 active site 243159005294 HIGH motif; other site 243159005295 nucleotide binding site [chemical binding]; other site 243159005296 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243159005297 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 243159005298 active site 243159005299 KMSKS motif; other site 243159005300 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 243159005301 tRNA binding surface [nucleotide binding]; other site 243159005302 anticodon binding site; other site 243159005303 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 243159005304 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 243159005305 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 243159005306 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 243159005307 dimerization interface [polypeptide binding]; other site 243159005308 active site 243159005309 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 243159005310 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243159005311 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243159005312 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 243159005313 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 243159005314 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 243159005315 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 243159005316 active site 243159005317 FMN binding site [chemical binding]; other site 243159005318 substrate binding site [chemical binding]; other site 243159005319 homotetramer interface [polypeptide binding]; other site 243159005320 catalytic residue [active] 243159005321 Protein of unknown function (DUF805); Region: DUF805; pfam05656 243159005322 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 243159005323 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243159005324 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 243159005325 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 243159005326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243159005327 motif II; other site 243159005328 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 243159005329 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243159005330 RNA binding surface [nucleotide binding]; other site 243159005331 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243159005332 active site 243159005333 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 243159005334 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 243159005335 homodimer interface [polypeptide binding]; other site 243159005336 oligonucleotide binding site [chemical binding]; other site 243159005337 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 243159005338 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 243159005339 active site 243159005340 HIGH motif; other site 243159005341 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 243159005342 KMSKS motif; other site 243159005343 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 243159005344 tRNA binding surface [nucleotide binding]; other site 243159005345 anticodon binding site; other site 243159005346 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 243159005347 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 243159005348 active site 243159005349 HIGH motif; other site 243159005350 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243159005351 active site 243159005352 KMSKS motif; other site 243159005353 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 243159005354 Transglycosylase; Region: Transgly; pfam00912 243159005355 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 243159005356 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 243159005357 Domain interface; other site 243159005358 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 243159005359 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 243159005360 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243159005361 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 243159005362 NAD binding site [chemical binding]; other site 243159005363 homodimer interface [polypeptide binding]; other site 243159005364 active site 243159005365 Phosphotransferase enzyme family; Region: APH; pfam01636 243159005366 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 243159005367 active site 243159005368 ATP binding site [chemical binding]; other site 243159005369 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 243159005370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243159005371 motif II; other site 243159005372 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243159005373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159005374 active site 243159005375 phosphorylation site [posttranslational modification] 243159005376 intermolecular recognition site; other site 243159005377 dimerization interface [polypeptide binding]; other site 243159005378 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243159005379 DNA binding site [nucleotide binding] 243159005380 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 243159005381 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 243159005382 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 243159005383 Ligand Binding Site [chemical binding]; other site 243159005384 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 243159005385 GAF domain; Region: GAF_3; pfam13492 243159005386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243159005387 dimer interface [polypeptide binding]; other site 243159005388 phosphorylation site [posttranslational modification] 243159005389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159005390 ATP binding site [chemical binding]; other site 243159005391 Mg2+ binding site [ion binding]; other site 243159005392 G-X-G motif; other site 243159005393 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 243159005394 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 243159005395 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243159005396 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243159005397 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 243159005398 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 243159005399 substrate binding site [chemical binding]; other site 243159005400 nucleotide binding site [chemical binding]; other site 243159005401 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 243159005402 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243159005403 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243159005404 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 243159005405 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243159005406 murein transglycosylase A; Provisional; Region: mltA; PRK11162 243159005407 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 243159005408 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243159005409 Trp docking motif [polypeptide binding]; other site 243159005410 active site 243159005411 PQQ-like domain; Region: PQQ_2; pfam13360 243159005412 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 243159005413 MG2 domain; Region: A2M_N; pfam01835 243159005414 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 243159005415 surface patch; other site 243159005416 Transglycosylase; Region: Transgly; pfam00912 243159005417 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 243159005418 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 243159005419 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 243159005420 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 243159005421 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 243159005422 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243159005423 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 243159005424 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243159005425 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 243159005426 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 243159005427 purine monophosphate binding site [chemical binding]; other site 243159005428 dimer interface [polypeptide binding]; other site 243159005429 putative catalytic residues [active] 243159005430 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 243159005431 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 243159005432 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 243159005433 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 243159005434 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243159005435 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 243159005436 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 243159005437 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 243159005438 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 243159005439 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 243159005440 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 243159005441 quinone interaction residues [chemical binding]; other site 243159005442 active site 243159005443 catalytic residues [active] 243159005444 FMN binding site [chemical binding]; other site 243159005445 substrate binding site [chemical binding]; other site 243159005446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159005447 Coenzyme A binding pocket [chemical binding]; other site 243159005448 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 243159005449 Phosphoesterase family; Region: Phosphoesterase; pfam04185 243159005450 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 243159005451 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243159005452 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243159005453 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243159005454 transcriptional regulator PhoB; Provisional; Region: PRK10161 243159005455 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243159005456 DNA binding site [nucleotide binding] 243159005457 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 243159005458 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243159005459 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243159005460 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243159005461 Phosphoesterase family; Region: Phosphoesterase; pfam04185 243159005462 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 243159005463 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 243159005464 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 243159005465 benzoate transport; Region: 2A0115; TIGR00895 243159005466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159005467 putative substrate translocation pore; other site 243159005468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159005469 phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293 243159005470 phosphonate C-P lyase system protein PhnH; Region: PhnH_redo; TIGR03292 243159005471 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 243159005472 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 243159005473 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 243159005474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243159005475 Walker A/P-loop; other site 243159005476 ATP binding site [chemical binding]; other site 243159005477 Q-loop/lid; other site 243159005478 ABC transporter signature motif; other site 243159005479 Walker B; other site 243159005480 D-loop; other site 243159005481 H-loop/switch region; other site 243159005482 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243159005483 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 243159005484 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243159005485 Walker A/P-loop; other site 243159005486 ATP binding site [chemical binding]; other site 243159005487 Q-loop/lid; other site 243159005488 ABC transporter signature motif; other site 243159005489 Walker B; other site 243159005490 D-loop; other site 243159005491 H-loop/switch region; other site 243159005492 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 243159005493 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243159005494 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243159005495 active site 243159005496 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 243159005497 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 243159005498 active site 243159005499 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 243159005500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243159005501 DNA-binding site [nucleotide binding]; DNA binding site 243159005502 UTRA domain; Region: UTRA; cl17743 243159005503 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243159005504 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243159005505 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243159005506 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243159005507 N-terminal plug; other site 243159005508 ligand-binding site [chemical binding]; other site 243159005509 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 243159005510 Phosphoesterase family; Region: Phosphoesterase; pfam04185 243159005511 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 243159005512 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 243159005513 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243159005514 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 243159005515 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243159005516 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 243159005517 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 243159005518 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243159005519 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243159005520 N-terminal plug; other site 243159005521 ligand-binding site [chemical binding]; other site 243159005522 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243159005523 Phosphoesterase family; Region: Phosphoesterase; pfam04185 243159005524 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 243159005525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243159005526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159005527 active site 243159005528 intermolecular recognition site; other site 243159005529 dimerization interface [polypeptide binding]; other site 243159005530 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243159005531 DNA binding site [nucleotide binding] 243159005532 phosphate:H+ symporter; Region: 2A0109; TIGR00887 243159005533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159005534 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 243159005535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159005536 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243159005537 catalytic core [active] 243159005538 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 243159005539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243159005540 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 243159005541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243159005542 dimer interface [polypeptide binding]; other site 243159005543 phosphorylation site [posttranslational modification] 243159005544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159005545 ATP binding site [chemical binding]; other site 243159005546 Mg2+ binding site [ion binding]; other site 243159005547 G-X-G motif; other site 243159005548 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243159005549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159005550 active site 243159005551 phosphorylation site [posttranslational modification] 243159005552 intermolecular recognition site; other site 243159005553 dimerization interface [polypeptide binding]; other site 243159005554 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243159005555 DNA binding site [nucleotide binding] 243159005556 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 243159005557 catalytic site [active] 243159005558 putative active site [active] 243159005559 putative substrate binding site [chemical binding]; other site 243159005560 dimer interface [polypeptide binding]; other site 243159005561 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 243159005562 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 243159005563 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 243159005564 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 243159005565 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243159005566 putative NAD(P) binding site [chemical binding]; other site 243159005567 active site 243159005568 putative substrate binding site [chemical binding]; other site 243159005569 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 243159005570 phosphoglucomutase; Region: PLN02307 243159005571 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 243159005572 substrate binding site [chemical binding]; other site 243159005573 dimer interface [polypeptide binding]; other site 243159005574 active site 243159005575 metal binding site [ion binding]; metal-binding site 243159005576 YtxH-like protein; Region: YtxH; cl02079 243159005577 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 243159005578 magnesium-transporting ATPase; Provisional; Region: PRK15122 243159005579 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243159005580 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243159005581 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243159005582 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243159005583 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 243159005584 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 243159005585 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243159005586 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243159005587 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 243159005588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159005589 putative substrate translocation pore; other site 243159005590 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 243159005591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159005592 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 243159005593 dimerization interface [polypeptide binding]; other site 243159005594 substrate binding pocket [chemical binding]; other site 243159005595 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 243159005596 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 243159005597 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 243159005598 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243159005599 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243159005600 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243159005601 DNA binding residues [nucleotide binding] 243159005602 DNA primase; Validated; Region: dnaG; PRK05667 243159005603 CHC2 zinc finger; Region: zf-CHC2; pfam01807 243159005604 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 243159005605 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 243159005606 active site 243159005607 metal binding site [ion binding]; metal-binding site 243159005608 interdomain interaction site; other site 243159005609 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 243159005610 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 243159005611 MutS domain III; Region: MutS_III; pfam05192 243159005612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159005613 Walker A/P-loop; other site 243159005614 ATP binding site [chemical binding]; other site 243159005615 Q-loop/lid; other site 243159005616 ABC transporter signature motif; other site 243159005617 Walker B; other site 243159005618 D-loop; other site 243159005619 H-loop/switch region; other site 243159005620 Smr domain; Region: Smr; pfam01713 243159005621 Yqey-like protein; Region: YqeY; pfam09424 243159005622 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 243159005623 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 243159005624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243159005625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243159005626 DNA binding residues [nucleotide binding] 243159005627 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 243159005628 active site 243159005629 dimerization interface [polypeptide binding]; other site 243159005630 ribonuclease PH; Reviewed; Region: rph; PRK00173 243159005631 Ribonuclease PH; Region: RNase_PH_bact; cd11362 243159005632 hexamer interface [polypeptide binding]; other site 243159005633 active site 243159005634 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243159005635 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243159005636 ligand binding site [chemical binding]; other site 243159005637 flexible hinge region; other site 243159005638 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 243159005639 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 243159005640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159005641 FeS/SAM binding site; other site 243159005642 HemN C-terminal domain; Region: HemN_C; pfam06969 243159005643 Uncharacterized conserved protein [Function unknown]; Region: COG3461 243159005644 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 243159005645 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243159005646 RNA binding surface [nucleotide binding]; other site 243159005647 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 243159005648 active site 243159005649 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243159005650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159005651 putative substrate translocation pore; other site 243159005652 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 243159005653 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 243159005654 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243159005655 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243159005656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159005657 S-adenosylmethionine binding site [chemical binding]; other site 243159005658 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 243159005659 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 243159005660 dimerization interface [polypeptide binding]; other site 243159005661 ATP binding site [chemical binding]; other site 243159005662 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 243159005663 dimerization interface [polypeptide binding]; other site 243159005664 ATP binding site [chemical binding]; other site 243159005665 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 243159005666 putative active site [active] 243159005667 catalytic triad [active] 243159005668 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 243159005669 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 243159005670 ATP binding site [chemical binding]; other site 243159005671 active site 243159005672 substrate binding site [chemical binding]; other site 243159005673 adenylosuccinate lyase; Provisional; Region: PRK07492 243159005674 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 243159005675 tetramer interface [polypeptide binding]; other site 243159005676 active site 243159005677 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 243159005678 dihydrodipicolinate synthase; Region: dapA; TIGR00674 243159005679 dimer interface [polypeptide binding]; other site 243159005680 active site 243159005681 catalytic residue [active] 243159005682 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 243159005683 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 243159005684 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 243159005685 active site 243159005686 metal binding site [ion binding]; metal-binding site 243159005687 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243159005688 thioredoxin 2; Provisional; Region: PRK10996 243159005689 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243159005690 catalytic residues [active] 243159005691 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 243159005692 GSH binding site [chemical binding]; other site 243159005693 catalytic residues [active] 243159005694 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243159005695 active site residue [active] 243159005696 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 243159005697 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243159005698 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243159005699 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 243159005700 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159005701 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243159005702 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243159005703 dimerization interface [polypeptide binding]; other site 243159005704 putative DNA binding site [nucleotide binding]; other site 243159005705 putative Zn2+ binding site [ion binding]; other site 243159005706 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243159005707 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 243159005708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159005709 S-adenosylmethionine binding site [chemical binding]; other site 243159005710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159005711 Walker B; other site 243159005712 D-loop; other site 243159005713 H-loop/switch region; other site 243159005714 Superfamily II helicase [General function prediction only]; Region: COG1204 243159005715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159005716 ATP binding site [chemical binding]; other site 243159005717 putative Mg++ binding site [ion binding]; other site 243159005718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243159005719 nucleotide binding region [chemical binding]; other site 243159005720 ATP-binding site [chemical binding]; other site 243159005721 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243159005722 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243159005723 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243159005724 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243159005725 Divergent AAA domain; Region: AAA_4; pfam04326 243159005726 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 243159005727 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 243159005728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159005729 ATP binding site [chemical binding]; other site 243159005730 putative Mg++ binding site [ion binding]; other site 243159005731 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 243159005732 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 243159005733 SCP-2 sterol transfer family; Region: SCP2; pfam02036 243159005734 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 243159005735 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 243159005736 putative ATP binding site [chemical binding]; other site 243159005737 putative substrate interface [chemical binding]; other site 243159005738 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 243159005739 active site 243159005740 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 243159005741 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243159005742 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243159005743 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 243159005744 Membrane fusogenic activity; Region: BMFP; pfam04380 243159005745 Transposase; Region: HTH_Tnp_1; cl17663 243159005746 Homeodomain-like domain; Region: HTH_32; pfam13565 243159005747 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 243159005748 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243159005749 active site 243159005750 DNA binding site [nucleotide binding] 243159005751 Int/Topo IB signature motif; other site 243159005752 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243159005753 integron integrase; Region: integrase_gron; TIGR02249 243159005754 active site 243159005755 DNA binding site [nucleotide binding] 243159005756 Int/Topo IB signature motif; other site 243159005757 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 243159005758 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 243159005759 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 243159005760 Int/Topo IB signature motif; other site 243159005761 Integrase core domain; Region: rve; pfam00665 243159005762 Helix-turn-helix domain; Region: HTH_38; pfam13936 243159005763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 243159005764 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 243159005765 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159005766 ATP binding site [chemical binding]; other site 243159005767 putative Mg++ binding site [ion binding]; other site 243159005768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 243159005769 nucleotide binding region [chemical binding]; other site 243159005770 ATP-binding site [chemical binding]; other site 243159005771 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 243159005772 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 243159005773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159005774 Coenzyme A binding pocket [chemical binding]; other site 243159005775 NADH dehydrogenase subunit B; Validated; Region: PRK06411 243159005776 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 243159005777 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243159005778 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 243159005779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159005780 Walker A motif; other site 243159005781 ATP binding site [chemical binding]; other site 243159005782 Walker B motif; other site 243159005783 Protein of unknown function (DUF497); Region: DUF497; cl01108 243159005784 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 243159005785 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 243159005786 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 243159005787 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 243159005788 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 243159005789 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 243159005790 DNA binding residues [nucleotide binding] 243159005791 dimer interface [polypeptide binding]; other site 243159005792 putative metal binding site [ion binding]; other site 243159005793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159005794 S-adenosylmethionine binding site [chemical binding]; other site 243159005795 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 243159005796 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243159005797 gamma subunit interface [polypeptide binding]; other site 243159005798 epsilon subunit interface [polypeptide binding]; other site 243159005799 LBP interface [polypeptide binding]; other site 243159005800 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 243159005801 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 243159005802 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 243159005803 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 243159005804 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243159005805 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243159005806 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243159005807 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243159005808 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243159005809 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243159005810 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159005811 Outer membrane efflux protein; Region: OEP; pfam02321 243159005812 Outer membrane efflux protein; Region: OEP; pfam02321 243159005813 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 243159005814 Predicted membrane protein [Function unknown]; Region: COG3462 243159005815 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 243159005816 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243159005817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243159005818 motif II; other site 243159005819 Domain of unknown function DUF302; Region: DUF302; pfam03625 243159005820 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243159005821 metal-binding site [ion binding] 243159005822 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 243159005823 catalytic residues [active] 243159005824 Cytochrome c; Region: Cytochrom_C; cl11414 243159005825 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 243159005826 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243159005827 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243159005828 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243159005829 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 243159005830 gamma-glutamyl kinase; Provisional; Region: PRK05429 243159005831 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 243159005832 nucleotide binding site [chemical binding]; other site 243159005833 homotetrameric interface [polypeptide binding]; other site 243159005834 putative phosphate binding site [ion binding]; other site 243159005835 putative allosteric binding site; other site 243159005836 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 243159005837 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 243159005838 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243159005839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159005840 Coenzyme A binding pocket [chemical binding]; other site 243159005841 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 243159005842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 243159005843 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 243159005844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 243159005845 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 243159005846 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 243159005847 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 243159005848 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243159005849 IHF - DNA interface [nucleotide binding]; other site 243159005850 IHF dimer interface [polypeptide binding]; other site 243159005851 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 243159005852 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 243159005853 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 243159005854 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243159005855 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243159005856 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 243159005857 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 243159005858 putative mercury transport protein MerC; Provisional; Region: PRK13755 243159005859 putative mercuric reductase; Provisional; Region: PRK13748 243159005860 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243159005861 metal-binding site [ion binding] 243159005862 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243159005863 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243159005864 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243159005865 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 243159005866 Domain interface; other site 243159005867 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 243159005868 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 243159005869 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 243159005870 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 243159005871 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 243159005872 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 243159005873 TniQ; Region: TniQ; pfam06527 243159005874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159005875 AAA domain; Region: AAA_22; pfam13401 243159005876 Walker A motif; other site 243159005877 ATP binding site [chemical binding]; other site 243159005878 Walker B motif; other site 243159005879 Helix-turn-helix domain; Region: HTH_28; pfam13518 243159005880 Winged helix-turn helix; Region: HTH_29; pfam13551 243159005881 Integrase core domain; Region: rve; pfam00665 243159005882 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 243159005883 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 243159005884 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 243159005885 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 243159005886 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 243159005887 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243159005888 DNA binding residues [nucleotide binding] 243159005889 dimer interface [polypeptide binding]; other site 243159005890 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243159005891 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 243159005892 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 243159005893 G1 box; other site 243159005894 putative GEF interaction site [polypeptide binding]; other site 243159005895 GTP/Mg2+ binding site [chemical binding]; other site 243159005896 Switch I region; other site 243159005897 G2 box; other site 243159005898 G3 box; other site 243159005899 Switch II region; other site 243159005900 G4 box; other site 243159005901 G5 box; other site 243159005902 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 243159005903 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 243159005904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159005905 Coenzyme A binding pocket [chemical binding]; other site 243159005906 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 243159005907 Glycoprotease family; Region: Peptidase_M22; pfam00814 243159005908 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 243159005909 DEAD/DEAH box helicase; Region: DEAD; pfam00270 243159005910 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 243159005911 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 243159005912 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243159005913 NlpC/P60 family; Region: NLPC_P60; pfam00877 243159005914 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 243159005915 FeoA domain; Region: FeoA; cl00838 243159005916 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 243159005917 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 243159005918 G1 box; other site 243159005919 GTP/Mg2+ binding site [chemical binding]; other site 243159005920 Switch I region; other site 243159005921 G2 box; other site 243159005922 G3 box; other site 243159005923 Switch II region; other site 243159005924 G4 box; other site 243159005925 G5 box; other site 243159005926 Nucleoside recognition; Region: Gate; pfam07670 243159005927 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 243159005928 FeoC like transcriptional regulator; Region: FeoC; cl17677 243159005929 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 243159005930 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 243159005931 putative active site; other site 243159005932 catalytic triad [active] 243159005933 putative dimer interface [polypeptide binding]; other site 243159005934 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 243159005935 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 243159005936 catalytic triad [active] 243159005937 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 243159005938 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243159005939 ornithine carbamoyltransferase; Provisional; Region: PRK00779 243159005940 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 243159005941 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 243159005942 conserved cys residue [active] 243159005943 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 243159005944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159005945 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 243159005946 putative dimerization interface [polypeptide binding]; other site 243159005947 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 243159005948 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243159005949 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243159005950 active site 243159005951 catalytic tetrad [active] 243159005952 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 243159005953 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 243159005954 active site 243159005955 Zn binding site [ion binding]; other site 243159005956 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243159005957 metal ion-dependent adhesion site (MIDAS); other site 243159005958 MoxR-like ATPases [General function prediction only]; Region: COG0714 243159005959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159005960 Walker A motif; other site 243159005961 ATP binding site [chemical binding]; other site 243159005962 Walker B motif; other site 243159005963 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 243159005964 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 243159005965 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 243159005966 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 243159005967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159005968 FeS/SAM binding site; other site 243159005969 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 243159005970 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243159005971 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 243159005972 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 243159005973 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243159005974 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 243159005975 lipoyl attachment site [posttranslational modification]; other site 243159005976 Predicted peroxiredoxins [General function prediction only]; Region: COG2044 243159005977 glycine cleavage system protein H; Provisional; Region: PRK13380 243159005978 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 243159005979 lipoyl attachment site [posttranslational modification]; other site 243159005980 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 243159005981 Cysteine-rich domain; Region: CCG; pfam02754 243159005982 Cysteine-rich domain; Region: CCG; pfam02754 243159005983 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243159005984 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 243159005985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243159005986 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 243159005987 Cysteine-rich domain; Region: CCG; pfam02754 243159005988 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 243159005989 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 243159005990 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 243159005991 CPxP motif; other site 243159005992 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243159005993 active site residue [active] 243159005994 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 243159005995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159005996 FeS/SAM binding site; other site 243159005997 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 243159005998 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 243159005999 trimer interface [polypeptide binding]; other site 243159006000 dimer interface [polypeptide binding]; other site 243159006001 putative active site [active] 243159006002 rod shape-determining protein MreB; Provisional; Region: PRK13927 243159006003 MreB and similar proteins; Region: MreB_like; cd10225 243159006004 nucleotide binding site [chemical binding]; other site 243159006005 Mg binding site [ion binding]; other site 243159006006 putative protofilament interaction site [polypeptide binding]; other site 243159006007 RodZ interaction site [polypeptide binding]; other site 243159006008 rod shape-determining protein MreC; Provisional; Region: PRK13922 243159006009 rod shape-determining protein MreC; Region: MreC; pfam04085 243159006010 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 243159006011 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 243159006012 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 243159006013 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243159006014 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 243159006015 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 243159006016 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 243159006017 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 243159006018 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 243159006019 lipoyl synthase; Provisional; Region: PRK05481 243159006020 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159006021 FeS/SAM binding site; other site 243159006022 Uncharacterized conserved protein [Function unknown]; Region: COG1434 243159006023 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 243159006024 putative active site [active] 243159006025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243159006026 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243159006027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159006028 active site 243159006029 phosphorylation site [posttranslational modification] 243159006030 intermolecular recognition site; other site 243159006031 dimerization interface [polypeptide binding]; other site 243159006032 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 243159006033 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 243159006034 G1 box; other site 243159006035 GTP/Mg2+ binding site [chemical binding]; other site 243159006036 G2 box; other site 243159006037 Switch I region; other site 243159006038 G3 box; other site 243159006039 Switch II region; other site 243159006040 G4 box; other site 243159006041 G5 box; other site 243159006042 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 243159006043 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 243159006044 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 243159006045 dimer interface [polypeptide binding]; other site 243159006046 motif 1; other site 243159006047 active site 243159006048 motif 2; other site 243159006049 motif 3; other site 243159006050 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 243159006051 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 243159006052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243159006053 active site 243159006054 motif I; other site 243159006055 motif II; other site 243159006056 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243159006057 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243159006058 putative acyl-acceptor binding pocket; other site 243159006059 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 243159006060 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243159006061 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 243159006062 Cysteine-rich domain; Region: CCG; pfam02754 243159006063 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 243159006064 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 243159006065 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 243159006066 amidase catalytic site [active] 243159006067 Zn binding residues [ion binding]; other site 243159006068 substrate binding site [chemical binding]; other site 243159006069 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243159006070 catalytic residues [active] 243159006071 glutathionine S-transferase; Provisional; Region: PRK10542 243159006072 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 243159006073 C-terminal domain interface [polypeptide binding]; other site 243159006074 GSH binding site (G-site) [chemical binding]; other site 243159006075 dimer interface [polypeptide binding]; other site 243159006076 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 243159006077 dimer interface [polypeptide binding]; other site 243159006078 N-terminal domain interface [polypeptide binding]; other site 243159006079 substrate binding pocket (H-site) [chemical binding]; other site 243159006080 Predicted transcriptional regulators [Transcription]; Region: COG1733 243159006081 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 243159006082 2-isopropylmalate synthase; Validated; Region: PRK00915 243159006083 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 243159006084 active site 243159006085 catalytic residues [active] 243159006086 metal binding site [ion binding]; metal-binding site 243159006087 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 243159006088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243159006089 PAS domain; Region: PAS_9; pfam13426 243159006090 putative active site [active] 243159006091 heme pocket [chemical binding]; other site 243159006092 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243159006093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159006094 Walker A motif; other site 243159006095 ATP binding site [chemical binding]; other site 243159006096 Walker B motif; other site 243159006097 arginine finger; other site 243159006098 Homeodomain-like domain; Region: HTH_23; pfam13384 243159006099 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 243159006100 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 243159006101 CPxP motif; other site 243159006102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 243159006103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243159006104 Methyltransferase domain; Region: Methyltransf_25; pfam13649 243159006105 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243159006106 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243159006107 Walker A/P-loop; other site 243159006108 ATP binding site [chemical binding]; other site 243159006109 Q-loop/lid; other site 243159006110 ABC transporter signature motif; other site 243159006111 Walker B; other site 243159006112 D-loop; other site 243159006113 H-loop/switch region; other site 243159006114 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 243159006115 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243159006116 DNA binding residues [nucleotide binding] 243159006117 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243159006118 IHF - DNA interface [nucleotide binding]; other site 243159006119 IHF dimer interface [polypeptide binding]; other site 243159006120 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 243159006121 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 243159006122 putative tRNA-binding site [nucleotide binding]; other site 243159006123 B3/4 domain; Region: B3_4; pfam03483 243159006124 tRNA synthetase B5 domain; Region: B5; smart00874 243159006125 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 243159006126 dimer interface [polypeptide binding]; other site 243159006127 motif 1; other site 243159006128 motif 3; other site 243159006129 motif 2; other site 243159006130 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 243159006131 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 243159006132 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 243159006133 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 243159006134 dimer interface [polypeptide binding]; other site 243159006135 motif 1; other site 243159006136 active site 243159006137 motif 2; other site 243159006138 motif 3; other site 243159006139 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 243159006140 23S rRNA binding site [nucleotide binding]; other site 243159006141 L21 binding site [polypeptide binding]; other site 243159006142 L13 binding site [polypeptide binding]; other site 243159006143 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 243159006144 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 243159006145 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 243159006146 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 243159006147 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 243159006148 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 243159006149 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 243159006150 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 243159006151 active site 243159006152 dimer interface [polypeptide binding]; other site 243159006153 motif 1; other site 243159006154 motif 2; other site 243159006155 motif 3; other site 243159006156 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 243159006157 anticodon binding site; other site 243159006158 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 243159006159 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243159006160 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 243159006161 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243159006162 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 243159006163 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 243159006164 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243159006165 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 243159006166 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 243159006167 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 243159006168 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 243159006169 4Fe-4S binding domain; Region: Fer4; pfam00037 243159006170 4Fe-4S binding domain; Region: Fer4; pfam00037 243159006171 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 243159006172 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 243159006173 NADH dehydrogenase subunit G; Validated; Region: PRK09129 243159006174 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243159006175 catalytic loop [active] 243159006176 iron binding site [ion binding]; other site 243159006177 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 243159006178 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243159006179 molybdopterin cofactor binding site; other site 243159006180 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 243159006181 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 243159006182 SLBB domain; Region: SLBB; pfam10531 243159006183 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 243159006184 NADH dehydrogenase subunit E; Validated; Region: PRK07539 243159006185 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 243159006186 putative dimer interface [polypeptide binding]; other site 243159006187 [2Fe-2S] cluster binding site [ion binding]; other site 243159006188 NADH dehydrogenase subunit D; Validated; Region: PRK06075 243159006189 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 243159006190 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 243159006191 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 243159006192 NADH dehydrogenase subunit B; Validated; Region: PRK06411 243159006193 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 243159006194 protein translocase, SecG subunit; Region: secG; TIGR00810 243159006195 triosephosphate isomerase; Provisional; Region: PRK14567 243159006196 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 243159006197 substrate binding site [chemical binding]; other site 243159006198 dimer interface [polypeptide binding]; other site 243159006199 catalytic triad [active] 243159006200 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 243159006201 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 243159006202 active site 243159006203 substrate binding site [chemical binding]; other site 243159006204 metal binding site [ion binding]; metal-binding site 243159006205 dihydropteroate synthase; Region: DHPS; TIGR01496 243159006206 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 243159006207 substrate binding pocket [chemical binding]; other site 243159006208 dimer interface [polypeptide binding]; other site 243159006209 inhibitor binding site; inhibition site 243159006210 FtsH Extracellular; Region: FtsH_ext; pfam06480 243159006211 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 243159006212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159006213 Walker A motif; other site 243159006214 ATP binding site [chemical binding]; other site 243159006215 Walker B motif; other site 243159006216 arginine finger; other site 243159006217 Peptidase family M41; Region: Peptidase_M41; pfam01434 243159006218 protease TldD; Provisional; Region: tldD; PRK10735 243159006219 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 243159006220 ATP cone domain; Region: ATP-cone; pfam03477 243159006221 ATP cone domain; Region: ATP-cone; pfam03477 243159006222 Class I ribonucleotide reductase; Region: RNR_I; cd01679 243159006223 active site 243159006224 dimer interface [polypeptide binding]; other site 243159006225 catalytic residues [active] 243159006226 effector binding site; other site 243159006227 R2 peptide binding site; other site 243159006228 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 243159006229 dimer interface [polypeptide binding]; other site 243159006230 putative radical transfer pathway; other site 243159006231 diiron center [ion binding]; other site 243159006232 tyrosyl radical; other site 243159006233 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243159006234 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243159006235 dimerization interface [polypeptide binding]; other site 243159006236 putative DNA binding site [nucleotide binding]; other site 243159006237 putative Zn2+ binding site [ion binding]; other site 243159006238 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243159006239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159006240 putative substrate translocation pore; other site 243159006241 DsrE/DsrF-like family; Region: DrsE; cl00672 243159006242 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243159006243 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 243159006244 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 243159006245 active site 243159006246 DNA polymerase IV; Validated; Region: PRK02406 243159006247 DNA binding site [nucleotide binding] 243159006248 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 243159006249 oligomeric interface; other site 243159006250 homodimer interface [polypeptide binding]; other site 243159006251 putative active site [active] 243159006252 Protein of unknown function DUF72; Region: DUF72; pfam01904 243159006253 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 243159006254 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243159006255 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 243159006256 trimer interface [polypeptide binding]; other site 243159006257 active site 243159006258 antiporter inner membrane protein; Provisional; Region: PRK11670 243159006259 Domain of unknown function DUF59; Region: DUF59; pfam01883 243159006260 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 243159006261 Walker A motif; other site 243159006262 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 243159006263 dihydrodipicolinate reductase; Provisional; Region: PRK00048 243159006264 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 243159006265 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 243159006266 chaperone protein DnaJ; Provisional; Region: PRK10767 243159006267 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243159006268 HSP70 interaction site [polypeptide binding]; other site 243159006269 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 243159006270 Zn binding sites [ion binding]; other site 243159006271 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243159006272 dimer interface [polypeptide binding]; other site 243159006273 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 243159006274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243159006275 nucleotide binding site [chemical binding]; other site 243159006276 GrpE; Region: GrpE; pfam01025 243159006277 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 243159006278 dimer interface [polypeptide binding]; other site 243159006279 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 243159006280 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 243159006281 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 243159006282 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 243159006283 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 243159006284 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 243159006285 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 243159006286 active site 243159006287 HIGH motif; other site 243159006288 KMSKS motif; other site 243159006289 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 243159006290 tRNA binding surface [nucleotide binding]; other site 243159006291 anticodon binding site; other site 243159006292 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 243159006293 dimer interface [polypeptide binding]; other site 243159006294 putative tRNA-binding site [nucleotide binding]; other site 243159006295 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 243159006296 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 243159006297 fumarate hydratase; Reviewed; Region: fumC; PRK00485 243159006298 Class II fumarases; Region: Fumarase_classII; cd01362 243159006299 active site 243159006300 tetramer interface [polypeptide binding]; other site 243159006301 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 243159006302 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 243159006303 active site 243159006304 Zn binding site [ion binding]; other site 243159006305 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 243159006306 chromosome segregation protein; Provisional; Region: PRK03918 243159006307 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 243159006308 glycogen synthase; Provisional; Region: glgA; PRK00654 243159006309 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 243159006310 ADP-binding pocket [chemical binding]; other site 243159006311 homodimer interface [polypeptide binding]; other site 243159006312 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 243159006313 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 243159006314 Beta-Casp domain; Region: Beta-Casp; smart01027 243159006315 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 243159006316 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 243159006317 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243159006318 minor groove reading motif; other site 243159006319 helix-hairpin-helix signature motif; other site 243159006320 substrate binding pocket [chemical binding]; other site 243159006321 active site 243159006322 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 243159006323 Domain of unknown function DUF29; Region: DUF29; pfam01724 243159006324 TPR repeat; Region: TPR_11; pfam13414 243159006325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006326 binding surface 243159006327 TPR motif; other site 243159006328 TPR repeat; Region: TPR_11; pfam13414 243159006329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006330 binding surface 243159006331 TPR motif; other site 243159006332 TPR repeat; Region: TPR_11; pfam13414 243159006333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006334 binding surface 243159006335 TPR motif; other site 243159006336 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243159006337 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243159006338 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 243159006339 trimer interface [polypeptide binding]; other site 243159006340 YadA-like C-terminal region; Region: YadA; pfam03895 243159006341 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243159006342 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243159006343 ligand binding site [chemical binding]; other site 243159006344 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243159006345 Sel1-like repeats; Region: SEL1; smart00671 243159006346 Sel1-like repeats; Region: SEL1; smart00671 243159006347 Sel1-like repeats; Region: SEL1; smart00671 243159006348 Sel1-like repeats; Region: SEL1; smart00671 243159006349 Gram-negative bacterial tonB protein; Region: TonB; cl10048 243159006350 Outer membrane efflux protein; Region: OEP; pfam02321 243159006351 Outer membrane efflux protein; Region: OEP; pfam02321 243159006352 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 243159006353 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243159006354 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159006355 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 243159006356 putative active site [active] 243159006357 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 243159006358 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243159006359 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 243159006360 Walker A/P-loop; other site 243159006361 ATP binding site [chemical binding]; other site 243159006362 Q-loop/lid; other site 243159006363 ABC transporter signature motif; other site 243159006364 Walker B; other site 243159006365 D-loop; other site 243159006366 H-loop/switch region; other site 243159006367 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 243159006368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159006369 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243159006370 Walker A motif; other site 243159006371 ATP binding site [chemical binding]; other site 243159006372 Walker B motif; other site 243159006373 arginine finger; other site 243159006374 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243159006375 Predicted membrane protein [Function unknown]; Region: COG4655 243159006376 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 243159006377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006378 binding surface 243159006379 TPR motif; other site 243159006380 TPR repeat; Region: TPR_11; pfam13414 243159006381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006382 binding surface 243159006383 TPR motif; other site 243159006384 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 243159006385 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243159006386 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 243159006387 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243159006388 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 243159006389 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 243159006390 ATP binding site [chemical binding]; other site 243159006391 Walker A motif; other site 243159006392 hexamer interface [polypeptide binding]; other site 243159006393 Walker B motif; other site 243159006394 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 243159006395 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 243159006396 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 243159006397 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243159006398 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 243159006399 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 243159006400 TadE-like protein; Region: TadE; pfam07811 243159006401 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 243159006402 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243159006403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243159006404 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243159006405 Flp/Fap pilin component; Region: Flp_Fap; cl01585 243159006406 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 243159006407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159006408 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 243159006409 Coenzyme A binding pocket [chemical binding]; other site 243159006410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006411 TPR motif; other site 243159006412 binding surface 243159006413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006414 binding surface 243159006415 TPR motif; other site 243159006416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006417 binding surface 243159006418 TPR motif; other site 243159006419 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243159006420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006421 binding surface 243159006422 TPR motif; other site 243159006423 TPR repeat; Region: TPR_11; pfam13414 243159006424 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 243159006425 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 243159006426 Class III ribonucleotide reductase; Region: RNR_III; cd01675 243159006427 effector binding site; other site 243159006428 active site 243159006429 Zn binding site [ion binding]; other site 243159006430 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 243159006431 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 243159006432 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243159006433 FeS/SAM binding site; other site 243159006434 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 243159006435 Protein of unknown function DUF116; Region: DUF116; cl00800 243159006436 putative protease; Provisional; Region: PRK15447 243159006437 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 243159006438 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 243159006439 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 243159006440 Peptidase family U32; Region: Peptidase_U32; pfam01136 243159006441 SCP-2 sterol transfer family; Region: SCP2; cl01225 243159006442 Cytochrome c; Region: Cytochrom_C; cl11414 243159006443 Cytochrome c; Region: Cytochrom_C; cl11414 243159006444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243159006445 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 243159006446 NAD(P) binding site [chemical binding]; other site 243159006447 active site 243159006448 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 243159006449 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 243159006450 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 243159006451 [2Fe-2S] cluster binding site [ion binding]; other site 243159006452 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 243159006453 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 243159006454 Qi binding site; other site 243159006455 intrachain domain interface; other site 243159006456 interchain domain interface [polypeptide binding]; other site 243159006457 heme bH binding site [chemical binding]; other site 243159006458 heme bL binding site [chemical binding]; other site 243159006459 Qo binding site; other site 243159006460 interchain domain interface [polypeptide binding]; other site 243159006461 intrachain domain interface; other site 243159006462 Qi binding site; other site 243159006463 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 243159006464 Qo binding site; other site 243159006465 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 243159006466 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 243159006467 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 243159006468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159006469 S-adenosylmethionine binding site [chemical binding]; other site 243159006470 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 243159006471 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 243159006472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159006473 S-adenosylmethionine binding site [chemical binding]; other site 243159006474 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 243159006475 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 243159006476 G1 box; other site 243159006477 putative GEF interaction site [polypeptide binding]; other site 243159006478 GTP/Mg2+ binding site [chemical binding]; other site 243159006479 Switch I region; other site 243159006480 G2 box; other site 243159006481 G3 box; other site 243159006482 Switch II region; other site 243159006483 G4 box; other site 243159006484 G5 box; other site 243159006485 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 243159006486 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 243159006487 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 243159006488 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 243159006489 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 243159006490 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 243159006491 Protein of unknown function, DUF484; Region: DUF484; cl17449 243159006492 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 243159006493 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243159006494 active site 243159006495 DNA binding site [nucleotide binding] 243159006496 Int/Topo IB signature motif; other site 243159006497 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 243159006498 active site 243159006499 HslU subunit interaction site [polypeptide binding]; other site 243159006500 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 243159006501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159006502 Walker A motif; other site 243159006503 ATP binding site [chemical binding]; other site 243159006504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159006505 Walker B motif; other site 243159006506 arginine finger; other site 243159006507 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243159006508 DsrE/DsrF-like family; Region: DrsE; cl00672 243159006509 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 243159006510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243159006511 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243159006512 DNA binding residues [nucleotide binding] 243159006513 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 243159006514 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 243159006515 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 243159006516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159006517 Walker A/P-loop; other site 243159006518 ATP binding site [chemical binding]; other site 243159006519 Q-loop/lid; other site 243159006520 ABC transporter signature motif; other site 243159006521 Walker B; other site 243159006522 D-loop; other site 243159006523 H-loop/switch region; other site 243159006524 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 243159006525 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 243159006526 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 243159006527 P loop; other site 243159006528 GTP binding site [chemical binding]; other site 243159006529 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 243159006530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159006531 S-adenosylmethionine binding site [chemical binding]; other site 243159006532 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 243159006533 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 243159006534 active site 243159006535 (T/H)XGH motif; other site 243159006536 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243159006537 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 243159006538 Dynamin family; Region: Dynamin_N; pfam00350 243159006539 G1 box; other site 243159006540 GTP/Mg2+ binding site [chemical binding]; other site 243159006541 G2 box; other site 243159006542 Switch I region; other site 243159006543 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 243159006544 G3 box; other site 243159006545 Switch II region; other site 243159006546 GTP/Mg2+ binding site [chemical binding]; other site 243159006547 G4 box; other site 243159006548 G5 box; other site 243159006549 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 243159006550 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 243159006551 DNA binding site [nucleotide binding] 243159006552 catalytic residue [active] 243159006553 H2TH interface [polypeptide binding]; other site 243159006554 putative catalytic residues [active] 243159006555 turnover-facilitating residue; other site 243159006556 intercalation triad [nucleotide binding]; other site 243159006557 8OG recognition residue [nucleotide binding]; other site 243159006558 putative reading head residues; other site 243159006559 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 243159006560 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243159006561 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 243159006562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159006563 peptide chain release factor 1; Validated; Region: prfA; PRK00591 243159006564 This domain is found in peptide chain release factors; Region: PCRF; smart00937 243159006565 RF-1 domain; Region: RF-1; pfam00472 243159006566 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 243159006567 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 243159006568 tRNA; other site 243159006569 putative tRNA binding site [nucleotide binding]; other site 243159006570 putative NADP binding site [chemical binding]; other site 243159006571 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 243159006572 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243159006573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006574 TPR motif; other site 243159006575 binding surface 243159006576 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243159006577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006578 TPR motif; other site 243159006579 binding surface 243159006580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006581 binding surface 243159006582 TPR motif; other site 243159006583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243159006584 binding surface 243159006585 TPR motif; other site 243159006586 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243159006587 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 243159006588 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 243159006589 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 243159006590 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 243159006591 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 243159006592 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243159006593 active site 243159006594 Integrase core domain; Region: rve_3; cl15866 243159006595 Restriction endonuclease; Region: Mrr_cat; pfam04471 243159006596 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243159006597 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 243159006598 putative S-transferase; Provisional; Region: PRK11752 243159006599 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 243159006600 C-terminal domain interface [polypeptide binding]; other site 243159006601 GSH binding site (G-site) [chemical binding]; other site 243159006602 dimer interface [polypeptide binding]; other site 243159006603 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 243159006604 dimer interface [polypeptide binding]; other site 243159006605 N-terminal domain interface [polypeptide binding]; other site 243159006606 active site 243159006607 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243159006608 benzoylformate decarboxylase; Reviewed; Region: PRK07092 243159006609 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243159006610 PYR/PP interface [polypeptide binding]; other site 243159006611 dimer interface [polypeptide binding]; other site 243159006612 TPP binding site [chemical binding]; other site 243159006613 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243159006614 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 243159006615 TPP-binding site [chemical binding]; other site 243159006616 dimer interface [polypeptide binding]; other site 243159006617 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243159006618 putative transposase OrfB; Reviewed; Region: PHA02517 243159006619 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 243159006620 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243159006621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243159006622 motif II; other site 243159006623 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 243159006624 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 243159006625 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 243159006626 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 243159006627 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 243159006628 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 243159006629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243159006630 ATP binding site [chemical binding]; other site 243159006631 putative Mg++ binding site [ion binding]; other site 243159006632 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 243159006633 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243159006634 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243159006635 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243159006636 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243159006637 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 243159006638 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243159006639 T5orf172 domain; Region: T5orf172; pfam10544 243159006640 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243159006641 dimerization interface [polypeptide binding]; other site 243159006642 putative DNA binding site [nucleotide binding]; other site 243159006643 putative Zn2+ binding site [ion binding]; other site 243159006644 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 243159006645 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 243159006646 DNA binding site [nucleotide binding] 243159006647 active site 243159006648 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 243159006649 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 243159006650 AlkA N-terminal domain; Region: AlkA_N; pfam06029 243159006651 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243159006652 minor groove reading motif; other site 243159006653 helix-hairpin-helix signature motif; other site 243159006654 active site 243159006655 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 243159006656 dimer interface [polypeptide binding]; other site 243159006657 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243159006658 metal binding site [ion binding]; metal-binding site 243159006659 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 243159006660 classical (c) SDRs; Region: SDR_c; cd05233 243159006661 NAD(P) binding site [chemical binding]; other site 243159006662 active site 243159006663 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 243159006664 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243159006665 Predicted flavoprotein [General function prediction only]; Region: COG0431 243159006666 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 243159006667 putative hydrophobic ligand binding site [chemical binding]; other site 243159006668 Cupin domain; Region: Cupin_2; cl17218 243159006669 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243159006670 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243159006671 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 243159006672 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 243159006673 proline aminopeptidase P II; Provisional; Region: PRK10879 243159006674 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 243159006675 active site 243159006676 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 243159006677 DNA repair protein RadA; Provisional; Region: PRK11823 243159006678 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 243159006679 Walker A motif/ATP binding site; other site 243159006680 ATP binding site [chemical binding]; other site 243159006681 Walker B motif; other site 243159006682 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 243159006683 alanine racemase; Reviewed; Region: alr; PRK00053 243159006684 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 243159006685 active site 243159006686 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243159006687 substrate binding site [chemical binding]; other site 243159006688 catalytic residues [active] 243159006689 dimer interface [polypeptide binding]; other site 243159006690 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 243159006691 replicative DNA helicase; Region: DnaB; TIGR00665 243159006692 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 243159006693 Walker A motif; other site 243159006694 ATP binding site [chemical binding]; other site 243159006695 Walker B motif; other site 243159006696 DNA binding loops [nucleotide binding] 243159006697 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 243159006698 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 243159006699 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 243159006700 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 243159006701 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 243159006702 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 243159006703 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 243159006704 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 243159006705 Amino acid permease; Region: AA_permease_2; pfam13520 243159006706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243159006707 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243159006708 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 243159006709 TRAM domain; Region: TRAM; cl01282 243159006710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243159006711 S-adenosylmethionine binding site [chemical binding]; other site 243159006712 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 243159006713 active site 243159006714 catalytic site [active] 243159006715 substrate binding site [chemical binding]; other site 243159006716 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 243159006717 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 243159006718 cysteine synthase B; Region: cysM; TIGR01138 243159006719 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 243159006720 dimer interface [polypeptide binding]; other site 243159006721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159006722 catalytic residue [active] 243159006723 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 243159006724 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 243159006725 putative active site [active] 243159006726 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 243159006727 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 243159006728 glycogen branching enzyme; Provisional; Region: PRK05402 243159006729 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 243159006730 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 243159006731 active site 243159006732 catalytic site [active] 243159006733 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 243159006734 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 243159006735 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 243159006736 ligand binding site; other site 243159006737 oligomer interface; other site 243159006738 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 243159006739 dimer interface [polypeptide binding]; other site 243159006740 N-terminal domain interface [polypeptide binding]; other site 243159006741 sulfate 1 binding site; other site 243159006742 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 243159006743 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 243159006744 putative active site [active] 243159006745 catalytic site [active] 243159006746 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 243159006747 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 243159006748 active site 243159006749 catalytic site [active] 243159006750 homodimer interface [polypeptide binding]; other site 243159006751 Lid 1; other site 243159006752 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 243159006753 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 243159006754 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 243159006755 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243159006756 nucleotide binding site [chemical binding]; other site 243159006757 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 243159006758 Protein of unknown function (DUF445); Region: DUF445; pfam04286 243159006759 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 243159006760 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 243159006761 dimer interface [polypeptide binding]; other site 243159006762 ssDNA binding site [nucleotide binding]; other site 243159006763 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243159006764 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 243159006765 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243159006766 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243159006767 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 243159006768 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 243159006769 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243159006770 catalytic residues [active] 243159006771 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243159006772 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243159006773 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243159006774 protein binding site [polypeptide binding]; other site 243159006775 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243159006776 protein binding site [polypeptide binding]; other site 243159006777 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 243159006778 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243159006779 active site 243159006780 DNA binding site [nucleotide binding] 243159006781 Int/Topo IB signature motif; other site 243159006782 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 243159006783 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 243159006784 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 243159006785 RimM N-terminal domain; Region: RimM; pfam01782 243159006786 PRC-barrel domain; Region: PRC; pfam05239 243159006787 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 243159006788 signal recognition particle protein; Provisional; Region: PRK10867 243159006789 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 243159006790 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 243159006791 P loop; other site 243159006792 GTP binding site [chemical binding]; other site 243159006793 Signal peptide binding domain; Region: SRP_SPB; pfam02978 243159006794 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 243159006795 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243159006796 arsenical pump membrane protein; Provisional; Region: PRK15445 243159006797 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 243159006798 transmembrane helices; other site 243159006799 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243159006800 dimerization interface [polypeptide binding]; other site 243159006801 putative DNA binding site [nucleotide binding]; other site 243159006802 putative Zn2+ binding site [ion binding]; other site 243159006803 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 243159006804 Low molecular weight phosphatase family; Region: LMWPc; cd00115 243159006805 active site 243159006806 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 243159006807 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243159006808 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159006809 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243159006810 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243159006811 Walker A/P-loop; other site 243159006812 ATP binding site [chemical binding]; other site 243159006813 Q-loop/lid; other site 243159006814 ABC transporter signature motif; other site 243159006815 Walker B; other site 243159006816 D-loop; other site 243159006817 H-loop/switch region; other site 243159006818 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 243159006819 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243159006820 Walker A/P-loop; other site 243159006821 ATP binding site [chemical binding]; other site 243159006822 Q-loop/lid; other site 243159006823 ABC transporter signature motif; other site 243159006824 Walker B; other site 243159006825 D-loop; other site 243159006826 H-loop/switch region; other site 243159006827 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243159006828 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 243159006829 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243159006830 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243159006831 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243159006832 catalytic residues [active] 243159006833 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 243159006834 glycine cleavage system protein H; Provisional; Region: PRK13380 243159006835 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 243159006836 lipoyl attachment site [posttranslational modification]; other site 243159006837 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 243159006838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243159006839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243159006840 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243159006841 putative effector binding pocket; other site 243159006842 dimerization interface [polypeptide binding]; other site 243159006843 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 243159006844 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 243159006845 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243159006846 substrate binding site [chemical binding]; other site 243159006847 activation loop (A-loop); other site 243159006848 Protein phosphatase 2C; Region: PP2C_2; pfam13672 243159006849 active site 243159006850 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243159006851 metal ion-dependent adhesion site (MIDAS); other site 243159006852 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 243159006853 Fe-S cluster binding site [ion binding]; other site 243159006854 active site 243159006855 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 243159006856 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 243159006857 PemK-like protein; Region: PemK; pfam02452 243159006858 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 243159006859 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 243159006860 putative active site [active] 243159006861 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 243159006862 Tic20-like protein; Region: Tic20; pfam09685 243159006863 ABC transporter ATPase component; Reviewed; Region: PRK11147 243159006864 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243159006865 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243159006866 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243159006867 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 243159006868 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 243159006869 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243159006870 O-Antigen ligase; Region: Wzy_C; pfam04932 243159006871 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 243159006872 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 243159006873 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243159006874 substrate binding pocket [chemical binding]; other site 243159006875 chain length determination region; other site 243159006876 substrate-Mg2+ binding site; other site 243159006877 catalytic residues [active] 243159006878 aspartate-rich region 1; other site 243159006879 active site lid residues [active] 243159006880 aspartate-rich region 2; other site 243159006881 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 243159006882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159006883 active site 243159006884 phosphorylation site [posttranslational modification] 243159006885 intermolecular recognition site; other site 243159006886 dimerization interface [polypeptide binding]; other site 243159006887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159006888 Walker A motif; other site 243159006889 ATP binding site [chemical binding]; other site 243159006890 Walker B motif; other site 243159006891 arginine finger; other site 243159006892 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243159006893 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243159006894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 243159006895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243159006896 dimer interface [polypeptide binding]; other site 243159006897 phosphorylation site [posttranslational modification] 243159006898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159006899 ATP binding site [chemical binding]; other site 243159006900 Mg2+ binding site [ion binding]; other site 243159006901 G-X-G motif; other site 243159006902 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 243159006903 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 243159006904 active site 243159006905 Uncharacterized conserved protein [Function unknown]; Region: COG2308 243159006906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 243159006907 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 243159006908 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 243159006909 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243159006910 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243159006911 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 243159006912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 243159006913 PrkA family serine protein kinase; Provisional; Region: PRK15455 243159006914 AAA ATPase domain; Region: AAA_16; pfam13191 243159006915 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 243159006916 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243159006917 hypothetical protein; Provisional; Region: PRK05325 243159006918 SpoVR family protein; Provisional; Region: PRK11767 243159006919 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 243159006920 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 243159006921 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243159006922 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243159006923 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243159006924 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 243159006925 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 243159006926 catalytic triad [active] 243159006927 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 243159006928 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 243159006929 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 243159006930 voltage-gated potassium channel; Provisional; Region: PRK10537 243159006931 Ion channel; Region: Ion_trans_2; pfam07885 243159006932 TrkA-N domain; Region: TrkA_N; pfam02254 243159006933 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 243159006934 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 243159006935 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 243159006936 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 243159006937 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 243159006938 active site 243159006939 dimer interface [polypeptide binding]; other site 243159006940 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 243159006941 dimer interface [polypeptide binding]; other site 243159006942 active site 243159006943 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 243159006944 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 243159006945 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 243159006946 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 243159006947 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1689 243159006948 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 243159006949 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 243159006950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159006951 S-adenosylmethionine binding site [chemical binding]; other site 243159006952 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 243159006953 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 243159006954 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 243159006955 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 243159006956 Family description; Region: UvrD_C_2; pfam13538 243159006957 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 243159006958 AAA domain; Region: AAA_30; pfam13604 243159006959 Family description; Region: UvrD_C_2; pfam13538 243159006960 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 243159006961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243159006962 DNA binding site [nucleotide binding] 243159006963 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243159006964 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243159006965 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 243159006966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 243159006967 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243159006968 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 243159006969 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 243159006970 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243159006971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243159006972 motif II; other site 243159006973 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243159006974 methionine sulfoxide reductase B; Provisional; Region: PRK00222 243159006975 SelR domain; Region: SelR; pfam01641 243159006976 methionine sulfoxide reductase A; Provisional; Region: PRK14054 243159006977 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243159006978 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 243159006979 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 243159006980 active site 243159006981 (T/H)XGH motif; other site 243159006982 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 243159006983 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 243159006984 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 243159006985 active site 243159006986 dimer interface [polypeptide binding]; other site 243159006987 ribonuclease G; Provisional; Region: PRK11712 243159006988 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 243159006989 homodimer interface [polypeptide binding]; other site 243159006990 oligonucleotide binding site [chemical binding]; other site 243159006991 response regulator GlrR; Provisional; Region: PRK15115 243159006992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159006993 active site 243159006994 phosphorylation site [posttranslational modification] 243159006995 intermolecular recognition site; other site 243159006996 dimerization interface [polypeptide binding]; other site 243159006997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159006998 Walker A motif; other site 243159006999 ATP binding site [chemical binding]; other site 243159007000 Walker B motif; other site 243159007001 arginine finger; other site 243159007002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243159007003 dimerization interface [polypeptide binding]; other site 243159007004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243159007005 dimer interface [polypeptide binding]; other site 243159007006 phosphorylation site [posttranslational modification] 243159007007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159007008 ATP binding site [chemical binding]; other site 243159007009 Mg2+ binding site [ion binding]; other site 243159007010 G-X-G motif; other site 243159007011 oxidative damage protection protein; Provisional; Region: PRK05408 243159007012 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 243159007013 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 243159007014 Substrate binding site; other site 243159007015 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 243159007016 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 243159007017 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 243159007018 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243159007019 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 243159007020 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 243159007021 Walker A/P-loop; other site 243159007022 ATP binding site [chemical binding]; other site 243159007023 Q-loop/lid; other site 243159007024 ABC transporter signature motif; other site 243159007025 Walker B; other site 243159007026 D-loop; other site 243159007027 H-loop/switch region; other site 243159007028 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 243159007029 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159007030 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 243159007031 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159007032 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243159007033 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 243159007034 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159007035 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 243159007036 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 243159007037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243159007038 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 243159007039 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243159007040 Active Sites [active] 243159007041 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 243159007042 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 243159007043 CysD dimerization site [polypeptide binding]; other site 243159007044 G1 box; other site 243159007045 putative GEF interaction site [polypeptide binding]; other site 243159007046 GTP/Mg2+ binding site [chemical binding]; other site 243159007047 Switch I region; other site 243159007048 G2 box; other site 243159007049 G3 box; other site 243159007050 Switch II region; other site 243159007051 G4 box; other site 243159007052 G5 box; other site 243159007053 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 243159007054 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 243159007055 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 243159007056 ligand-binding site [chemical binding]; other site 243159007057 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243159007058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243159007059 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243159007060 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 243159007061 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 243159007062 active site 243159007063 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 243159007064 polysaccharide export protein Wza; Provisional; Region: PRK15078 243159007065 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243159007066 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 243159007067 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159007068 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 243159007069 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 243159007070 NADP-binding site; other site 243159007071 homotetramer interface [polypeptide binding]; other site 243159007072 substrate binding site [chemical binding]; other site 243159007073 homodimer interface [polypeptide binding]; other site 243159007074 active site 243159007075 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 243159007076 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243159007077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159007078 S-adenosylmethionine binding site [chemical binding]; other site 243159007079 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243159007080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159007081 S-adenosylmethionine binding site [chemical binding]; other site 243159007082 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 243159007083 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 243159007084 putative active site [active] 243159007085 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243159007086 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243159007087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159007088 Walker A/P-loop; other site 243159007089 ATP binding site [chemical binding]; other site 243159007090 Q-loop/lid; other site 243159007091 ABC transporter signature motif; other site 243159007092 Walker B; other site 243159007093 D-loop; other site 243159007094 H-loop/switch region; other site 243159007095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159007096 Coenzyme A binding pocket [chemical binding]; other site 243159007097 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 243159007098 peptide binding site [polypeptide binding]; other site 243159007099 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 243159007100 dimer interface [polypeptide binding]; other site 243159007101 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 243159007102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243159007103 Walker A/P-loop; other site 243159007104 ATP binding site [chemical binding]; other site 243159007105 Q-loop/lid; other site 243159007106 ABC transporter signature motif; other site 243159007107 Walker B; other site 243159007108 D-loop; other site 243159007109 H-loop/switch region; other site 243159007110 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243159007111 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 243159007112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243159007113 Walker A/P-loop; other site 243159007114 ATP binding site [chemical binding]; other site 243159007115 Q-loop/lid; other site 243159007116 ABC transporter signature motif; other site 243159007117 Walker B; other site 243159007118 D-loop; other site 243159007119 H-loop/switch region; other site 243159007120 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243159007121 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 243159007122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243159007123 ABC-ATPase subunit interface; other site 243159007124 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 243159007125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243159007126 dimer interface [polypeptide binding]; other site 243159007127 conserved gate region; other site 243159007128 putative PBP binding loops; other site 243159007129 ABC-ATPase subunit interface; other site 243159007130 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 243159007131 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 243159007132 peptide binding site [polypeptide binding]; other site 243159007133 dimer interface [polypeptide binding]; other site 243159007134 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 243159007135 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243159007136 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 243159007137 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243159007138 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 243159007139 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243159007140 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 243159007141 malate dehydrogenase; Reviewed; Region: PRK06223 243159007142 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 243159007143 NAD(P) binding site [chemical binding]; other site 243159007144 substrate binding site [chemical binding]; other site 243159007145 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 243159007146 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 243159007147 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243159007148 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243159007149 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243159007150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159007151 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 243159007152 Coenzyme A binding pocket [chemical binding]; other site 243159007153 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 243159007154 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243159007155 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 243159007156 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243159007157 active site 243159007158 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243159007159 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 243159007160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243159007161 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 243159007162 Enoylreductase; Region: PKS_ER; smart00829 243159007163 NAD(P) binding site [chemical binding]; other site 243159007164 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 243159007165 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 243159007166 putative NADP binding site [chemical binding]; other site 243159007167 active site 243159007168 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243159007169 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 243159007170 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 243159007171 substrate-cofactor binding pocket; other site 243159007172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159007173 catalytic residue [active] 243159007174 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 243159007175 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 243159007176 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 243159007177 short chain dehydrogenase; Provisional; Region: PRK07024 243159007178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243159007179 NAD(P) binding site [chemical binding]; other site 243159007180 active site 243159007181 Sulfatase; Region: Sulfatase; cl17466 243159007182 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 243159007183 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243159007184 minor groove reading motif; other site 243159007185 helix-hairpin-helix signature motif; other site 243159007186 substrate binding pocket [chemical binding]; other site 243159007187 active site 243159007188 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 243159007189 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 243159007190 DNA binding and oxoG recognition site [nucleotide binding] 243159007191 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 243159007192 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 243159007193 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 243159007194 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243159007195 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243159007196 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 243159007197 regulatory protein interface [polypeptide binding]; other site 243159007198 active site 243159007199 regulatory phosphorylation site [posttranslational modification]; other site 243159007200 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 243159007201 active site 243159007202 active pocket/dimerization site; other site 243159007203 phosphorylation site [posttranslational modification] 243159007204 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 243159007205 AAA domain; Region: AAA_33; pfam13671 243159007206 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 243159007207 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 243159007208 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 243159007209 Hpr binding site; other site 243159007210 active site 243159007211 homohexamer subunit interaction site [polypeptide binding]; other site 243159007212 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 243159007213 active site 243159007214 phosphorylation site [posttranslational modification] 243159007215 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 243159007216 30S subunit binding site; other site 243159007217 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 243159007218 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 243159007219 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 243159007220 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 243159007221 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 243159007222 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 243159007223 Walker A/P-loop; other site 243159007224 ATP binding site [chemical binding]; other site 243159007225 Q-loop/lid; other site 243159007226 ABC transporter signature motif; other site 243159007227 Walker B; other site 243159007228 D-loop; other site 243159007229 H-loop/switch region; other site 243159007230 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 243159007231 OstA-like protein; Region: OstA; pfam03968 243159007232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 243159007233 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 243159007234 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 243159007235 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 243159007236 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 243159007237 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 243159007238 putative active site [active] 243159007239 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 243159007240 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 243159007241 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 243159007242 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 243159007243 Substrate binding site; other site 243159007244 metal-binding site 243159007245 Phosphotransferase enzyme family; Region: APH; pfam01636 243159007246 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 243159007247 active site 243159007248 ATP binding site [chemical binding]; other site 243159007249 substrate binding site [chemical binding]; other site 243159007250 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 243159007251 OstA-like protein; Region: OstA; cl00844 243159007252 Organic solvent tolerance protein; Region: OstA_C; pfam04453 243159007253 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 243159007254 SurA N-terminal domain; Region: SurA_N; pfam09312 243159007255 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243159007256 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243159007257 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243159007258 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243159007259 BolA-like protein; Region: BolA; pfam01722 243159007260 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 243159007261 putative GSH binding site [chemical binding]; other site 243159007262 catalytic residues [active] 243159007263 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 243159007264 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 243159007265 hinge; other site 243159007266 active site 243159007267 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 243159007268 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 243159007269 histidinol dehydrogenase; Region: hisD; TIGR00069 243159007270 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 243159007271 NAD binding site [chemical binding]; other site 243159007272 dimerization interface [polypeptide binding]; other site 243159007273 product binding site; other site 243159007274 substrate binding site [chemical binding]; other site 243159007275 zinc binding site [ion binding]; other site 243159007276 catalytic residues [active] 243159007277 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 243159007278 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243159007279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159007280 homodimer interface [polypeptide binding]; other site 243159007281 catalytic residue [active] 243159007282 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 243159007283 putative active site pocket [active] 243159007284 4-fold oligomerization interface [polypeptide binding]; other site 243159007285 metal binding residues [ion binding]; metal-binding site 243159007286 3-fold/trimer interface [polypeptide binding]; other site 243159007287 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 243159007288 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 243159007289 putative active site [active] 243159007290 oxyanion strand; other site 243159007291 catalytic triad [active] 243159007292 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 243159007293 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 243159007294 catalytic residues [active] 243159007295 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 243159007296 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 243159007297 substrate binding site [chemical binding]; other site 243159007298 glutamase interaction surface [polypeptide binding]; other site 243159007299 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 243159007300 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 243159007301 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 243159007302 metal binding site [ion binding]; metal-binding site 243159007303 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 243159007304 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 243159007305 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 243159007306 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 243159007307 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 243159007308 dimer interface [polypeptide binding]; other site 243159007309 catalytic residue [active] 243159007310 metal binding site [ion binding]; metal-binding site 243159007311 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 243159007312 multimerization interface [polypeptide binding]; other site 243159007313 MoxR-like ATPases [General function prediction only]; Region: COG0714 243159007314 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 243159007315 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 243159007316 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 243159007317 metal ion-dependent adhesion site (MIDAS); other site 243159007318 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243159007319 GAF domain; Region: GAF; pfam01590 243159007320 PAS domain; Region: PAS_9; pfam13426 243159007321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243159007322 putative active site [active] 243159007323 heme pocket [chemical binding]; other site 243159007324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243159007325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243159007326 metal binding site [ion binding]; metal-binding site 243159007327 active site 243159007328 I-site; other site 243159007329 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243159007330 dihydroorotase; Validated; Region: pyrC; PRK09357 243159007331 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243159007332 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 243159007333 active site 243159007334 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 243159007335 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243159007336 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243159007337 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243159007338 active site 243159007339 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 243159007340 hypothetical protein; Validated; Region: PRK00228 243159007341 glutathione synthetase; Provisional; Region: PRK05246 243159007342 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 243159007343 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 243159007344 Glutamate-cysteine ligase; Region: GshA; pfam08886 243159007345 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 243159007346 citrate synthase; Provisional; Region: PRK14036 243159007347 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 243159007348 dimer interface [polypeptide binding]; other site 243159007349 active site 243159007350 citrylCoA binding site [chemical binding]; other site 243159007351 oxalacetate/citrate binding site [chemical binding]; other site 243159007352 coenzyme A binding site [chemical binding]; other site 243159007353 catalytic triad [active] 243159007354 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 243159007355 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243159007356 E3 interaction surface; other site 243159007357 lipoyl attachment site [posttranslational modification]; other site 243159007358 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243159007359 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 243159007360 E3 interaction surface; other site 243159007361 lipoyl attachment site [posttranslational modification]; other site 243159007362 e3 binding domain; Region: E3_binding; pfam02817 243159007363 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243159007364 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 243159007365 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243159007366 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243159007367 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 243159007368 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 243159007369 alpha subunit interface [polypeptide binding]; other site 243159007370 TPP binding site [chemical binding]; other site 243159007371 heterodimer interface [polypeptide binding]; other site 243159007372 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243159007373 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 243159007374 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 243159007375 tetramer interface [polypeptide binding]; other site 243159007376 TPP-binding site [chemical binding]; other site 243159007377 heterodimer interface [polypeptide binding]; other site 243159007378 phosphorylation loop region [posttranslational modification] 243159007379 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 243159007380 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 243159007381 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 243159007382 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 243159007383 23S rRNA interface [nucleotide binding]; other site 243159007384 L3 interface [polypeptide binding]; other site 243159007385 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 243159007386 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 243159007387 dimer interface [polypeptide binding]; other site 243159007388 FMN binding site [chemical binding]; other site 243159007389 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 243159007390 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 243159007391 active site 243159007392 HIGH motif; other site 243159007393 dimer interface [polypeptide binding]; other site 243159007394 KMSKS motif; other site 243159007395 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243159007396 RNA binding surface [nucleotide binding]; other site 243159007397 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 243159007398 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 243159007399 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243159007400 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243159007401 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cl00540 243159007402 tetramerization interface [polypeptide binding]; other site 243159007403 active site 243159007404 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 243159007405 G1 box; other site 243159007406 GTP/Mg2+ binding site [chemical binding]; other site 243159007407 Switch I region; other site 243159007408 G2 box; other site 243159007409 G3 box; other site 243159007410 Switch II region; other site 243159007411 G4 box; other site 243159007412 G5 box; other site 243159007413 voltage-gated potassium channel; Provisional; Region: PRK10537 243159007414 Ion channel; Region: Ion_trans_2; pfam07885 243159007415 TrkA-N domain; Region: TrkA_N; pfam02254 243159007416 DNA polymerase I; Provisional; Region: PRK05755 243159007417 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 243159007418 active site 243159007419 metal binding site 1 [ion binding]; metal-binding site 243159007420 putative 5' ssDNA interaction site; other site 243159007421 metal binding site 3; metal-binding site 243159007422 metal binding site 2 [ion binding]; metal-binding site 243159007423 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 243159007424 putative DNA binding site [nucleotide binding]; other site 243159007425 putative metal binding site [ion binding]; other site 243159007426 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 243159007427 active site 243159007428 substrate binding site [chemical binding]; other site 243159007429 catalytic site [active] 243159007430 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 243159007431 active site 243159007432 DNA binding site [nucleotide binding] 243159007433 catalytic site [active] 243159007434 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 243159007435 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 243159007436 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 243159007437 Phosphotransferase enzyme family; Region: APH; pfam01636 243159007438 putative active site [active] 243159007439 putative substrate binding site [chemical binding]; other site 243159007440 ATP binding site [chemical binding]; other site 243159007441 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 243159007442 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 243159007443 Helix-hairpin-helix motif; Region: HHH; pfam00633 243159007444 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 243159007445 Part of AAA domain; Region: AAA_19; pfam13245 243159007446 Family description; Region: UvrD_C_2; pfam13538 243159007447 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 243159007448 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243159007449 HSP70 interaction site [polypeptide binding]; other site 243159007450 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243159007451 substrate binding site [polypeptide binding]; other site 243159007452 dimer interface [polypeptide binding]; other site 243159007453 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 243159007454 hypothetical protein; Provisional; Region: PRK08609 243159007455 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 243159007456 active site 243159007457 primer binding site [nucleotide binding]; other site 243159007458 NTP binding site [chemical binding]; other site 243159007459 metal binding triad [ion binding]; metal-binding site 243159007460 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 243159007461 active site 243159007462 DDE superfamily endonuclease; Region: DDE_3; pfam13358 243159007463 Cytochrome c; Region: Cytochrom_C; cl11414 243159007464 Cytochrome c; Region: Cytochrom_C; cl11414 243159007465 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 243159007466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243159007467 NAD(P) binding site [chemical binding]; other site 243159007468 active site 243159007469 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 243159007470 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 243159007471 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 243159007472 [2Fe-2S] cluster binding site [ion binding]; other site 243159007473 cytochrome b; Provisional; Region: CYTB; MTH00145 243159007474 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 243159007475 Qi binding site; other site 243159007476 intrachain domain interface; other site 243159007477 interchain domain interface [polypeptide binding]; other site 243159007478 heme bH binding site [chemical binding]; other site 243159007479 heme bL binding site [chemical binding]; other site 243159007480 Qo binding site; other site 243159007481 interchain domain interface [polypeptide binding]; other site 243159007482 intrachain domain interface; other site 243159007483 Qi binding site; other site 243159007484 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 243159007485 Qo binding site; other site 243159007486 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 243159007487 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 243159007488 ResB-like family; Region: ResB; pfam05140 243159007489 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 243159007490 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 243159007491 Predicted membrane protein [Function unknown]; Region: COG3431 243159007492 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 243159007493 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 243159007494 CPxP motif; other site 243159007495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 243159007496 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243159007497 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 243159007498 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 243159007499 Flavodoxin; Region: Flavodoxin_1; pfam00258 243159007500 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 243159007501 FAD binding pocket [chemical binding]; other site 243159007502 FAD binding motif [chemical binding]; other site 243159007503 catalytic residues [active] 243159007504 NAD binding pocket [chemical binding]; other site 243159007505 phosphate binding motif [ion binding]; other site 243159007506 beta-alpha-beta structure motif; other site 243159007507 sulfite reductase subunit beta; Provisional; Region: PRK13504 243159007508 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243159007509 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243159007510 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 243159007511 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243159007512 Active Sites [active] 243159007513 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 243159007514 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243159007515 Active Sites [active] 243159007516 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 243159007517 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 243159007518 CysD dimerization site [polypeptide binding]; other site 243159007519 G1 box; other site 243159007520 putative GEF interaction site [polypeptide binding]; other site 243159007521 GTP/Mg2+ binding site [chemical binding]; other site 243159007522 Switch I region; other site 243159007523 G2 box; other site 243159007524 G3 box; other site 243159007525 Switch II region; other site 243159007526 G4 box; other site 243159007527 G5 box; other site 243159007528 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 243159007529 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 243159007530 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 243159007531 active site 243159007532 SAM binding site [chemical binding]; other site 243159007533 homodimer interface [polypeptide binding]; other site 243159007534 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 243159007535 putative active site [active] 243159007536 OsmC-like protein; Region: OsmC; pfam02566 243159007537 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 243159007538 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 243159007539 Cl- selectivity filter; other site 243159007540 Cl- binding residues [ion binding]; other site 243159007541 pore gating glutamate residue; other site 243159007542 dimer interface [polypeptide binding]; other site 243159007543 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 243159007544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243159007545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 243159007546 phosphorylation site [posttranslational modification] 243159007547 dimer interface [polypeptide binding]; other site 243159007548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159007549 ATP binding site [chemical binding]; other site 243159007550 Mg2+ binding site [ion binding]; other site 243159007551 G-X-G motif; other site 243159007552 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 243159007553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159007554 active site 243159007555 phosphorylation site [posttranslational modification] 243159007556 intermolecular recognition site; other site 243159007557 dimerization interface [polypeptide binding]; other site 243159007558 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243159007559 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 243159007560 Rrf2 family protein; Region: rrf2_super; TIGR00738 243159007561 Transcriptional regulator; Region: Rrf2; pfam02082 243159007562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159007563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243159007564 putative substrate translocation pore; other site 243159007565 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 243159007566 UbiA prenyltransferase family; Region: UbiA; pfam01040 243159007567 rusticyanin; Region: rusti_cyanin; TIGR03095 243159007568 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 243159007569 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cd00919 243159007570 D-pathway; other site 243159007571 Low-spin heme binding site [chemical binding]; other site 243159007572 Putative water exit pathway; other site 243159007573 Binuclear center (active site) [active] 243159007574 K-pathway; other site 243159007575 Putative proton exit pathway; other site 243159007576 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 243159007577 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 243159007578 Cytochrome c; Region: Cytochrom_C; cl11414 243159007579 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243159007580 Cytochrome c; Region: Cytochrom_C; cl11414 243159007581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 243159007582 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 243159007583 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 243159007584 Winged helix-turn helix; Region: HTH_33; pfam13592 243159007585 heat shock protein 90; Provisional; Region: PRK05218 243159007586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159007587 ATP binding site [chemical binding]; other site 243159007588 Mg2+ binding site [ion binding]; other site 243159007589 G-X-G motif; other site 243159007590 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 243159007591 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 243159007592 putative ligand binding site [chemical binding]; other site 243159007593 putative NAD binding site [chemical binding]; other site 243159007594 catalytic site [active] 243159007595 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243159007596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159007597 Coenzyme A binding pocket [chemical binding]; other site 243159007598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243159007599 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 243159007600 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 243159007601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243159007602 Walker A/P-loop; other site 243159007603 ATP binding site [chemical binding]; other site 243159007604 Q-loop/lid; other site 243159007605 ABC transporter signature motif; other site 243159007606 Walker B; other site 243159007607 D-loop; other site 243159007608 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 243159007609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243159007610 Coenzyme A binding pocket [chemical binding]; other site 243159007611 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243159007612 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243159007613 Cupin domain; Region: Cupin_2; cl17218 243159007614 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 243159007615 putative hydrophobic ligand binding site [chemical binding]; other site 243159007616 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 243159007617 dimer interface [polypeptide binding]; other site 243159007618 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243159007619 metal binding site [ion binding]; metal-binding site 243159007620 PIN domain; Region: PIN_2; pfam10130 243159007621 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 243159007622 transposase; Validated; Region: PRK08181 243159007623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159007624 Walker A motif; other site 243159007625 ATP binding site [chemical binding]; other site 243159007626 Integrase core domain; Region: rve; pfam00665 243159007627 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243159007628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243159007629 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243159007630 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 243159007631 Mrr N-terminal domain; Region: Mrr_N; pfam14338 243159007632 Restriction endonuclease; Region: Mrr_cat; pfam04471 243159007633 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 243159007634 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 243159007635 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 243159007636 DNA methylase; Region: N6_N4_Mtase; pfam01555 243159007637 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 243159007638 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 243159007639 Divergent AAA domain; Region: AAA_4; pfam04326 243159007640 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 243159007641 AAA domain; Region: AAA_22; pfam13401 243159007642 Integrase core domain; Region: rve; pfam00665 243159007643 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 243159007644 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 243159007645 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 243159007646 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 243159007647 glutaminase active site [active] 243159007648 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 243159007649 dimer interface [polypeptide binding]; other site 243159007650 active site 243159007651 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 243159007652 dimer interface [polypeptide binding]; other site 243159007653 active site 243159007654 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 243159007655 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 243159007656 Substrate binding site; other site 243159007657 Mg++ binding site; other site 243159007658 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 243159007659 active site 243159007660 substrate binding site [chemical binding]; other site 243159007661 CoA binding site [chemical binding]; other site 243159007662 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 243159007663 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243159007664 gamma subunit interface [polypeptide binding]; other site 243159007665 epsilon subunit interface [polypeptide binding]; other site 243159007666 LBP interface [polypeptide binding]; other site 243159007667 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 243159007668 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243159007669 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 243159007670 alpha subunit interaction interface [polypeptide binding]; other site 243159007671 Walker A motif; other site 243159007672 ATP binding site [chemical binding]; other site 243159007673 Walker B motif; other site 243159007674 inhibitor binding site; inhibition site 243159007675 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243159007676 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 243159007677 core domain interface [polypeptide binding]; other site 243159007678 delta subunit interface [polypeptide binding]; other site 243159007679 epsilon subunit interface [polypeptide binding]; other site 243159007680 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 243159007681 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243159007682 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 243159007683 beta subunit interaction interface [polypeptide binding]; other site 243159007684 Walker A motif; other site 243159007685 ATP binding site [chemical binding]; other site 243159007686 Walker B motif; other site 243159007687 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243159007688 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 243159007689 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 243159007690 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 243159007691 ATP synthase, F0 subunit b; Region: ATP_synt_b; TIGR01144 243159007692 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 243159007693 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 243159007694 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 243159007695 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 243159007696 ParB-like nuclease domain; Region: ParBc; pfam02195 243159007697 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243159007698 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243159007699 P-loop; other site 243159007700 Magnesium ion binding site [ion binding]; other site 243159007701 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243159007702 Magnesium ion binding site [ion binding]; other site 243159007703 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 243159007704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159007705 S-adenosylmethionine binding site [chemical binding]; other site 243159007706 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 243159007707 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 243159007708 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 243159007709 NlpE N-terminal domain; Region: NlpE; pfam04170 243159007710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243159007711 S-adenosylmethionine binding site [chemical binding]; other site 243159007712 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 243159007713 MPT binding site; other site 243159007714 trimer interface [polypeptide binding]; other site 243159007715 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 243159007716 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 243159007717 Cl binding site [ion binding]; other site 243159007718 oligomer interface [polypeptide binding]; other site 243159007719 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 243159007720 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 243159007721 Cl binding site [ion binding]; other site 243159007722 oligomer interface [polypeptide binding]; other site 243159007723 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 243159007724 oligomer interface [polypeptide binding]; other site 243159007725 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 243159007726 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 243159007727 Cl binding site [ion binding]; other site 243159007728 oligomer interface [polypeptide binding]; other site 243159007729 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 243159007730 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 243159007731 Pirin-related protein [General function prediction only]; Region: COG1741 243159007732 Pirin; Region: Pirin; pfam02678 243159007733 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 243159007734 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 243159007735 Protein of unknown function (DUF541); Region: SIMPL; cl01077 243159007736 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243159007737 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243159007738 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243159007739 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 243159007740 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243159007741 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243159007742 nodulation ABC transporter NodI; Provisional; Region: PRK13537 243159007743 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 243159007744 Walker A/P-loop; other site 243159007745 ATP binding site [chemical binding]; other site 243159007746 Q-loop/lid; other site 243159007747 ABC transporter signature motif; other site 243159007748 Walker B; other site 243159007749 D-loop; other site 243159007750 H-loop/switch region; other site 243159007751 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243159007752 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 243159007753 dimer interface [polypeptide binding]; other site 243159007754 [2Fe-2S] cluster binding site [ion binding]; other site 243159007755 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 243159007756 diiron binding motif [ion binding]; other site 243159007757 Rrf2 family protein; Region: rrf2_super; TIGR00738 243159007758 Transcriptional regulator; Region: Rrf2; pfam02082 243159007759 OsmC-like protein; Region: OsmC; cl00767 243159007760 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 243159007761 active site 243159007762 ribulose/triose binding site [chemical binding]; other site 243159007763 phosphate binding site [ion binding]; other site 243159007764 substrate (anthranilate) binding pocket [chemical binding]; other site 243159007765 product (indole) binding pocket [chemical binding]; other site 243159007766 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 243159007767 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 243159007768 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 243159007769 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 243159007770 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 243159007771 glutamine binding [chemical binding]; other site 243159007772 catalytic triad [active] 243159007773 anthranilate synthase component I; Provisional; Region: PRK13565 243159007774 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 243159007775 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 243159007776 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 243159007777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243159007778 motif II; other site 243159007779 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 243159007780 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 243159007781 substrate binding site [chemical binding]; other site 243159007782 hexamer interface [polypeptide binding]; other site 243159007783 metal binding site [ion binding]; metal-binding site 243159007784 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 243159007785 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 243159007786 intersubunit interface [polypeptide binding]; other site 243159007787 active site 243159007788 zinc binding site [ion binding]; other site 243159007789 Na+ binding site [ion binding]; other site 243159007790 pyruvate kinase; Provisional; Region: PRK05826 243159007791 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 243159007792 domain interfaces; other site 243159007793 active site 243159007794 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 243159007795 Phosphoglycerate kinase; Region: PGK; pfam00162 243159007796 substrate binding site [chemical binding]; other site 243159007797 hinge regions; other site 243159007798 ADP binding site [chemical binding]; other site 243159007799 catalytic site [active] 243159007800 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 243159007801 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 243159007802 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 243159007803 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 243159007804 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 243159007805 TPP-binding site [chemical binding]; other site 243159007806 dimer interface [polypeptide binding]; other site 243159007807 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243159007808 PYR/PP interface [polypeptide binding]; other site 243159007809 dimer interface [polypeptide binding]; other site 243159007810 TPP binding site [chemical binding]; other site 243159007811 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 243159007812 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 243159007813 putative active site [active] 243159007814 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 243159007815 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 243159007816 active site 243159007817 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 243159007818 RNA methyltransferase, RsmE family; Region: TIGR00046 243159007819 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 243159007820 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 243159007821 RmuC family; Region: RmuC; pfam02646 243159007822 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 243159007823 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 243159007824 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 243159007825 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243159007826 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243159007827 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243159007828 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243159007829 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243159007830 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243159007831 HlyD family secretion protein; Region: HlyD_3; pfam13437 243159007832 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243159007833 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 243159007834 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 243159007835 PIN domain; Region: PIN_3; cl17397 243159007836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 243159007837 ATP binding site [chemical binding]; other site 243159007838 Mg2+ binding site [ion binding]; other site 243159007839 G-X-G motif; other site 243159007840 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 243159007841 dimer interface [polypeptide binding]; other site 243159007842 osmolarity response regulator; Provisional; Region: ompR; PRK09468 243159007843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243159007844 active site 243159007845 phosphorylation site [posttranslational modification] 243159007846 intermolecular recognition site; other site 243159007847 dimerization interface [polypeptide binding]; other site 243159007848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243159007849 DNA binding site [nucleotide binding] 243159007850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243159007851 dimerization interface [polypeptide binding]; other site 243159007852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243159007853 dimer interface [polypeptide binding]; other site 243159007854 phosphorylation site [posttranslational modification] 243159007855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243159007856 ATP binding site [chemical binding]; other site 243159007857 Mg2+ binding site [ion binding]; other site 243159007858 G-X-G motif; other site 243159007859 argininosuccinate lyase; Provisional; Region: PRK00855 243159007860 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 243159007861 active sites [active] 243159007862 tetramer interface [polypeptide binding]; other site 243159007863 diaminopimelate decarboxylase; Region: lysA; TIGR01048 243159007864 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 243159007865 active site 243159007866 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243159007867 substrate binding site [chemical binding]; other site 243159007868 catalytic residues [active] 243159007869 dimer interface [polypeptide binding]; other site 243159007870 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 243159007871 substrate binding site [chemical binding]; other site 243159007872 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 243159007873 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 243159007874 putative substrate-binding site; other site 243159007875 nickel binding site [ion binding]; other site 243159007876 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 243159007877 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 243159007878 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 243159007879 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 243159007880 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243159007881 Cysteine-rich domain; Region: CCG; pfam02754 243159007882 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 243159007883 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 243159007884 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 243159007885 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 243159007886 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243159007887 HupF/HypC family; Region: HupF_HypC; pfam01455 243159007888 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 243159007889 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 243159007890 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243159007891 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 243159007892 NADP-binding site; other site 243159007893 homotetramer interface [polypeptide binding]; other site 243159007894 substrate binding site [chemical binding]; other site 243159007895 homodimer interface [polypeptide binding]; other site 243159007896 active site 243159007897 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 243159007898 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 243159007899 NADP-binding site; other site 243159007900 homotetramer interface [polypeptide binding]; other site 243159007901 substrate binding site [chemical binding]; other site 243159007902 homodimer interface [polypeptide binding]; other site 243159007903 active site 243159007904 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 243159007905 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 243159007906 Substrate binding site; other site 243159007907 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 243159007908 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 243159007909 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 243159007910 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 243159007911 substrate binding site; other site 243159007912 tetramer interface; other site 243159007913 benzoate transport; Region: 2A0115; TIGR00895 243159007914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159007915 putative substrate translocation pore; other site 243159007916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243159007917 TonB C terminal; Region: TonB_2; pfam13103 243159007918 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 243159007919 dimer interface [polypeptide binding]; other site 243159007920 active site 243159007921 Schiff base residues; other site 243159007922 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 243159007923 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 243159007924 active site 243159007925 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 243159007926 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 243159007927 domain interfaces; other site 243159007928 active site 243159007929 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 243159007930 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 243159007931 nucleotide binding site/active site [active] 243159007932 HIT family signature motif; other site 243159007933 catalytic residue [active] 243159007934 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 243159007935 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243159007936 inhibitor-cofactor binding pocket; inhibition site 243159007937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243159007938 catalytic residue [active] 243159007939 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 243159007940 thiamine phosphate binding site [chemical binding]; other site 243159007941 active site 243159007942 pyrophosphate binding site [ion binding]; other site 243159007943 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 243159007944 dimer interface [polypeptide binding]; other site 243159007945 substrate binding site [chemical binding]; other site 243159007946 ATP binding site [chemical binding]; other site 243159007947 short chain dehydrogenase; Provisional; Region: PRK07024 243159007948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243159007949 NAD(P) binding site [chemical binding]; other site 243159007950 active site 243159007951 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 243159007952 DnaA N-terminal domain; Region: DnaA_N; pfam11638 243159007953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243159007954 Walker A motif; other site 243159007955 ATP binding site [chemical binding]; other site 243159007956 Walker B motif; other site 243159007957 arginine finger; other site 243159007958 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 243159007959 DnaA box-binding interface [nucleotide binding]; other site